Hub : Genes

CAPN1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Artery Tibial 0.1241 0.0447 0.00028 0.124 NA 0.093 NA 0.113 6.1e-10 NA 1.0e-07 NA 3.8e-09
2 GTEx Colon Transverse 0.2050 0.0760 0.00370 0.167 NA 0.090 NA 0.133 2.4e-08 NA 4.7e-05 NA 6.9e-07
3 METSIM Adipose 0.1934 0.0399 0.00000 0.129 0.157 0.160 0.162 0.157 1.0e-18 8.5e-23 3.7e-23 1.6e-23 8.0e-23
4 YFS Blood 0.2256 0.0348 0.00000 0.141 0.182 0.196 0.200 0.195 6.9e-44 3.7e-57 5.8e-62 3.6e-63 1.1e-61
5 TCGA Lung Squamous Cell Carcinoma 0.0324 0.0162 0.00066 0.023 0.020 0.015 NA 0.016 1.1e-03 2.1e-03 7.1e-03 NA 5.1e-03
6 TCGA Prostate Adenocarcinoma 0.0441 0.0221 0.00049 0.056 0.024 0.027 NA 0.044 1.5e-06 1.2e-03 7.8e-04 NA 2.2e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 0.4 0.6 0.9 0.2 -1.0 -0.7 -0.9 0.7 -1.0
Bipolar Disorder or Schizophrenia 0.7 1.6 2.2 1.1 -1.2 -1.5 -1.4 1.2 -1.2
Depressed Affect (Nagel 2018) 0.3 0.6 2.3 -0.2 0.4 0.7 0.6 -1.5 0.3
Depression (Nagel 2018) 0.2 0.3 1.4 0.0 0.2 0.3 0.3 -1.2 0.2
Intelligence (Savage-Jansen 2018) 0.3 0.8 3.0 -1.7 -0.3 -0.3 -0.8 -1.1 -0.3
Neuroticism (Nagel 2018) 0.3 0.7 3.8 0.4 0.2 0.3 0.0 -2.0 0.2
Schizophrenia (2018) 0.5 1.1 1.8 1.2 -0.8 -1.3 -1.0 1.0 -0.8
Schizophrenia vs Biploar Disorder 0.4 0.5 1.5 -0.3 -0.6 -0.8 -1.2 0.6 -0.6
Worry (Nagel 2018) 0.5 1.0 3.6 0.4 -0.7 -0.5 -1.1 -1.9 -0.7
Alzheimer’s Disease (in mother) 0.3 0.4 1.0 0.5 -0.6 -0.6 0.4 1.0 -0.6
Alzheimer’s Disease (in father) 0.9 1.0 1.8 -0.6 -1.3 -0.5 -0.8 -1.1 -1.3
Alzheimer’s Disease (including proxy) 0.5 0.7 1.3 -0.2 -1.1 -0.9 -0.6 0.5 -1.1
Crohns Disease (2017) 0.3 0.7 1.3 -1.2 1.0 0.6 0.1 -0.5 1.1
Irritable Bowel Disease (IBD) 0.2 0.4 1.2 -1.1 0.5 0.3 -0.7 -0.4 0.6
Ulcerative Colitis (UC) 0.4 0.7 2.5 -0.9 -0.6 -0.2 -1.6 -0.4 -0.5
Major Depression (MDD) 0.3 0.4 1.0 1.0 -0.6 0.0 -0.7 -0.3 -0.6
Reaction Time 0.5 0.9 3.4 0.2 -0.0 -1.0 -1.1 1.8 -0.0
Verbal and Numeric Reasoning (VNR) 0.8 1.9 7.6 -2.8 0.4 0.9 -0.1 -1.7 0.5
Breast Cancer 1.1 2.6 4.8 -2.2 1.8 1.3 1.2 1.1 1.8
Ovarian Cancer 0.3 0.4 0.9 0.4 -0.9 -0.4 -0.6 -0.3 -1.0
Prostate Cancer 0.5 0.7 2.5 -1.6 -0.1 -0.1 -0.7 -1.2 -0.2
Age at First Birth 0.1 0.2 0.5 0.7 -0.4 0.2 -0.4 -0.4 -0.4
Bipolar Disorder (2011) 0.0 0.0 0.1 0.0 0.0 0.0 0.0 -0.0 0.2
Body Mass Index (BMI) (2010) 0.6 0.8 2.1 -0.4 -0.8 -0.5 -1.5 -0.9 -0.9
Coronary Artery Disease (CAD) 2.6 3.1 8.8 0.2 1.8 3.0 1.3 -1.2 1.7
Crohns Disease (2012) 0.5 0.7 1.7 -1.3 -0.8 -0.4 -1.0 -0.7 -0.8
Mean Putamen Volume 2.0 2.2 3.8 1.7 -1.4 -1.6 -0.7 1.9 -1.3
Fasting Glucose 0.7 0.8 1.8 0.1 1.2 -0.3 -0.0 1.2 1.4
HbA1C 1.0 1.1 2.4 1.2 1.5 -0.0 0.4 0.3 1.5
HDL Cholesterol 4.6 7.7 13.4 2.7 -3.7 -2.8 -2.0 -0.3 -3.7
LDL Cholesterol 0.6 1.0 2.1 0.8 -0.8 -1.4 -0.3 1.3 -0.8
Lupus 0.3 0.5 1.1 -1.1 0.5 0.9 0.6 0.4 0.5
Neuroticism (2016) 0.1 0.1 0.4 0.6 -0.2 -0.6 -0.1 -0.1 -0.2
Primary Biliary Cirrhosis 0.2 0.3 1.0 -1.0 -0.2 -0.0 -0.9 -0.2 -0.1
Rheumatoid Arthritis 1.5 2.1 9.6 -0.0 -0.9 -0.1 -1.0 -3.1 -1.0
Schizophrenia (2014) 0.2 0.4 1.7 1.3 -0.4 -0.4 -0.6 0.3 -0.4
Triglycerides 1.8 2.9 5.7 0.5 2.4 1.8 1.6 0.6 2.4
Type 2 Diabetes (T2D) (2012) 0.4 0.4 2.2 0.5 0.1 -0.1 0.2 1.5 -0.0
Ulcerative Colitis 0.5 0.7 1.7 0.0 -0.9 -1.0 -1.3 -0.4 -0.8
Blood Eosinophil Count 1.0 7.7 20.6 0.6 2.6 3.2 4.5 -1.2 2.6
Blood Platelet Count 0.5 5.8 20.2 4.5 -0.1 0.1 3.8 0.0 -0.2
Blood Red Count 0.4 4.1 17.9 -4.2 0.8 0.7 0.2 -2.1 0.9
Blood White Count 0.4 2.9 14.9 -3.9 0.5 0.9 -0.5 0.9 0.6
Heel T-Score 0.2 1.7 7.0 -1.3 0.3 1.1 -0.5 -2.6 0.3
BMI 0.6 3.2 7.7 -2.8 1.8 1.4 -0.1 -1.8 1.8
Height 1.3 24.4 112.4 -1.9 0.7 5.3 1.3 -10.6 0.0
Waist Hip Ratio (WHR) 0.6 2.8 8.5 -1.2 -1.1 -2.2 -2.9 0.5 -0.9
Systolic Blood Pressure 1.8 8.8 13.1 -3.6 3.3 3.6 2.3 -0.3 3.3
Smoking Status 1.4 3.4 11.9 -2.0 1.1 1.5 -0.1 -3.5 1.0
Allergy or Eczema 0.7 2.0 4.1 -0.3 -2.0 -0.9 -1.5 -0.9 -2.0
Cardiovascular Disease 2.1 6.9 18.5 -4.3 2.7 2.3 1.5 0.2 2.8
Hypothyroidism (self reported) 0.5 1.2 2.7 0.2 0.7 1.0 1.6 -1.6 0.7
Respiratory disease 0.2 0.4 1.4 0.7 -0.5 -1.2 -0.6 -0.1 -0.4
Type 2 Diabetes (T2D) (2018) 1.8 3.3 11.2 -3.3 1.4 1.1 -0.2 1.8 1.5
Lung FEV1/FVC ratio 0.1 0.4 1.9 0.2 -0.2 0.4 0.7 1.4 -0.2
Lung FVC 1.2 6.1 15.3 -0.1 -2.4 -1.2 -2.7 -3.9 -2.6
Neuroticism 0.3 0.7 4.0 0.4 0.0 0.1 0.2 -2.0 0.0
Chronotype (morning person) 0.0 0.1 0.2 0.5 0.1 0.1 0.4 0.1 0.0
Hair Pigment 0.1 1.7 3.8 1.4 -1.2 0.4 0.7 -1.9 -1.5
Tanning 0.1 1.5 4.0 0.0 -0.5 -1.7 -2.0 1.3 -0.4
Hand grip strength (left) 1.0 2.5 6.0 -0.5 1.6 2.4 1.7 -1.1 1.5
Number of treatments/medications taken 1.0 1.8 5.6 -2.4 0.8 1.2 1.6 0.3 0.8
Average weekly spirits intake 0.5 0.6 2.1 -1.5 0.1 0.9 0.4 0.4 0.0
Sensitivity / hurt feelings 0.1 0.2 0.4 0.3 0.6 0.4 0.6 -0.1 0.6
Frequency of depressed mood in last 2 weeks 0.3 0.4 0.9 -0.8 -0.5 -0.7 -0.9 -0.1 -0.5
Hearing difficulty/problems: Yes 0.3 0.5 2.1 0.2 -0.2 -1.5 -0.3 0.7 -0.2
Relative age of first facial hair 1.0 2.1 3.6 -0.4 1.9 1.5 1.0 1.4 1.9
Other serious medical condition/disability diagnosed by doctor 1.6 2.1 11.0 -3.3 0.4 1.0 -0.3 -0.7 0.4
Ever used hormone-replacement therapy (HRT) 1.6 2.0 3.0 1.2 -1.5 -1.5 -1.7 -0.9 -1.6
Ever had hysterectomy (womb removed) 0.3 0.3 0.8 -0.9 0.3 0.1 -0.8 -0.7 0.2
Systolic blood pressure, automated reading 1.0 2.9 6.1 -2.5 1.4 2.3 1.3 -0.6 1.4
Eye problems/disorders: Diabetes related eye disease 0.1 0.1 0.2 0.5 -0.1 -0.4 -0.0 0.1 -0.1
Angina 0.2 0.2 0.4 0.6 -0.7 0.1 0.3 0.5 -0.6
Medication for hormone replacement therapy 1.7 2.0 3.1 0.0 1.7 1.5 1.6 0.9 1.8
Vitamin and mineral supplements 0.4 0.6 1.8 0.4 -0.1 -0.4 -1.1 -1.4 -0.1
Supplements: Zinc 0.7 0.8 2.2 0.6 0.3 -0.0 1.3 1.5 0.4
Medication: Co-codamol 1.0 1.2 2.4 -1.0 1.1 1.6 1.1 -0.2 1.1
Medication: Metformin 1.3 1.8 8.3 -2.9 0.4 0.1 -1.2 0.8 0.5
Diabetes (father) 0.4 0.4 1.2 -0.9 -0.3 -0.2 -1.1 0.6 -0.3
Diabetes (mother) 1.1 1.4 3.2 -1.8 1.3 0.5 1.2 -0.0 1.4
Severe depression (siblings) 0.2 0.3 0.9 0.9 -0.5 -0.3 0.1 -0.2 -0.6
Pack years adult smoking proportion 0.4 0.6 1.7 -0.9 0.1 -0.5 -1.0 -1.3 0.1
Impedance of leg (right) 0.6 3.1 11.9 3.5 -1.3 -1.4 -0.5 1.0 -1.3
Leg fat-free mass (left) 2.1 11.0 26.1 -4.1 2.0 3.9 0.6 -5.1 1.7
Trunk fat percentage 1.2 4.8 10.3 -3.2 2.1 2.6 0.4 -1.6 2.0
Hand grip strength (right) 1.8 5.0 9.8 -2.0 2.3 3.1 2.0 -1.5 2.2
Townsend deprivation index at recruitment 1.5 2.1 5.1 -2.1 -0.6 -1.4 -2.3 -0.3 -0.5
Current tobacco smoking 3.1 5.1 11.8 -0.0 -2.5 -2.3 -3.4 -1.0 -2.5
Average weekly fortified wine intake 0.8 1.0 2.2 1.3 0.7 1.0 1.5 -0.3 0.6
Maternal smoking around birth 3.0 4.3 8.7 -1.4 2.9 2.1 1.5 -0.5 3.0
Fed-up feelings 1.8 3.3 5.2 -1.1 1.8 2.3 2.1 -1.5 1.8
Frequency of unenthusiasm / disinterest in last 2 weeks 0.1 0.1 0.4 -0.0 -0.1 -0.6 -0.6 -0.3 -0.1
Relative age voice broke 0.9 1.3 6.1 -0.2 0.9 0.5 0.1 2.5 0.9
Taking other prescription medications 2.0 3.1 14.0 -3.7 0.6 1.2 0.5 -1.4 0.6
Age when periods started (menarche) 0.2 0.5 1.5 1.2 0.3 0.2 0.5 1.1 0.3
Bilateral oophorectomy (both ovaries removed) 0.2 0.3 0.7 0.2 0.8 -0.1 -0.2 0.5 0.8
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.4 0.9 0.1 0.4 0.8 1.0 -0.7 0.5
Tinnitus: Yes, but not now, but have in the past 0.5 0.6 2.5 0.6 -0.1 0.5 0.4 -1.6 -0.1
Qualifications: CSEs or equivalent 2.4 3.2 5.8 -0.4 1.7 2.4 1.7 -2.3 1.5
Serious illness, injury or assault to yourself 0.5 0.6 2.2 -1.5 0.2 0.5 -1.0 -0.3 0.1
High blood pressure 1.7 4.7 14.2 -3.8 2.1 1.6 1.2 0.3 2.2
Hayfever, allergic rhinitis or eczema 0.3 0.6 1.3 0.8 -1.1 -0.3 -0.2 -0.7 -1.1
Multivitamins +/- minerals 0.7 0.8 2.2 0.3 0.2 1.2 1.5 1.1 0.2
Stomach or abdominal pain in last month 0.2 0.2 0.5 -0.5 0.3 0.7 -0.1 -0.6 0.3
Supplements: Glucosamine 1.2 1.6 4.6 1.7 0.5 1.0 2.1 -0.9 0.5
Diverticular disease/diverticulitis (self-reported) 0.7 0.8 1.9 -0.2 0.9 0.8 0.8 1.4 1.0
Medication: Atenolol 2.5 3.2 7.6 0.2 1.7 2.1 2.8 1.0 1.7
Medication: Levothyroxine sodium 0.6 1.1 1.9 0.6 -1.2 -1.2 -0.2 -1.4 -1.2
Sitting height 0.4 3.1 12.6 -1.7 0.1 1.8 -0.2 -3.5 -0.1
Chronic bronchitis/emphysema (father) 1.6 1.8 3.5 -0.1 -1.3 -1.9 -1.7 1.1 -1.2
High blood pressure (mother) 1.1 1.6 3.0 -0.3 1.4 1.7 1.4 -0.6 1.4
Body mass index (BMI) 1.2 5.1 15.6 -4.0 2.0 2.0 0.0 -1.8 1.9
Impedance of leg (left) 0.6 2.8 11.7 3.4 -1.1 -1.3 -0.2 1.1 -1.1
Leg predicted mass (left) 2.1 10.9 26.6 -4.0 2.0 3.9 0.6 -5.2 1.7
Trunk fat mass 1.7 7.4 15.5 -3.9 2.2 3.3 0.4 -3.0 2.0
Waist circumference 1.7 6.3 17.1 -4.1 1.7 2.4 -0.4 -3.1 1.6
Number of incorrect matches in round 0.8 1.3 4.8 1.5 0.4 0.6 2.2 0.0 0.3
Past tobacco smoking 1.5 2.7 5.7 1.5 -1.6 -1.8 -0.6 2.4 -1.5
Alcohol usually taken with meals 0.9 1.5 4.3 2.1 0.6 0.7 1.3 -1.4 0.5
Nervous feelings 0.2 0.4 1.3 0.6 -0.5 -1.1 -0.3 -0.6 -0.4
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.4 1.5 0.4 0.3 0.6 0.6 -1.2 0.3
Hearing difficulty/problems with background noise 0.9 1.4 3.2 0.1 -1.5 -1.8 -0.9 -0.1 -1.4
Hair/balding pattern: Pattern 2 0.7 0.9 2.2 0.2 -0.6 -0.8 -1.3 -1.5 -0.7
Had menopause 1.7 2.1 5.6 2.4 -1.3 -1.3 -1.1 -0.7 -1.4
Had other major operations 0.6 0.8 1.8 -1.4 -0.1 0.9 -0.5 -1.3 -0.1
Forced vital capacity (FVC) 0.9 3.6 17.1 -1.1 -0.6 1.1 -1.0 -4.1 -0.8
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.4 1.0 -0.0 0.4 1.0 0.8 -0.7 0.4
Ever unenthusiastic/disinterested for a whole week 0.4 0.4 1.5 -0.9 0.4 -0.0 0.1 1.2 0.4
Qualifications: None of the above 0.3 0.7 1.6 -1.3 0.1 0.1 -1.2 -0.9 0.1
Financial difficulties in last 2 years 0.8 1.0 2.1 -0.1 1.4 0.9 0.8 -0.8 1.4
Mouth/teeth dental problems 0.4 0.7 1.6 0.1 0.5 1.2 0.8 1.3 0.4
Heart attack 0.7 0.9 1.8 -0.8 -1.0 -1.0 -1.3 0.6 -0.8
Allergy 0.1 0.3 1.4 -0.2 0.3 -0.3 0.0 1.2 0.3
Pain all over the body in last month 0.1 0.1 0.4 -0.6 0.3 0.3 -0.1 -0.4 0.3
Diabetes (self-reported) 1.3 2.1 8.4 -2.9 0.5 0.1 -0.3 1.8 0.6
Hayfever/allergic rhinitis (self-reported) 0.6 0.8 2.6 -0.4 -0.7 -0.8 -0.8 -1.6 -0.7
Medication: Ramipril 0.8 1.1 5.0 -2.2 -0.3 0.7 -0.6 0.6 -0.3
Medication: Simvastatin 0.3 0.4 1.9 -1.4 0.0 0.0 0.0 0.6 0.1
Fluid intelligence score 0.6 1.2 2.1 -1.5 1.1 1.4 0.7 -0.3 1.1
Illnesses of siblings 0.4 0.6 2.2 0.3 -0.3 -0.9 -1.5 0.6 -0.3
Neuroticism score 0.2 0.5 2.0 0.4 0.2 0.2 0.8 -1.4 0.2
Weight 2.2 10.8 23.7 -4.4 2.1 3.7 0.3 -4.9 1.8
Impedance of arm (right) 0.5 2.5 6.3 2.1 -1.0 -1.3 -0.7 2.5 -0.9
Arm fat percentage (right) 0.8 3.2 13.5 -3.7 1.3 1.2 -0.8 -0.6 1.3
Trunk fat-free mass 1.9 10.7 45.2 -2.7 0.8 3.3 0.1 -6.7 0.4
Hip circumference 2.7 11.4 21.3 -4.1 2.6 4.6 1.6 -4.0 2.4
Time employed in main current job 1.0 1.1 2.3 1.5 -1.3 -0.8 -0.3 -0.5 -1.3
Alcohol intake versus 10 years previously 3.7 5.6 8.4 -1.5 2.9 2.8 2.0 -1.6 2.8
Father’s age at death 1.6 2.2 5.1 0.8 1.6 1.5 2.2 -0.4 1.6
Worrier / anxious feelings 0.8 1.5 3.0 1.2 1.2 0.8 1.7 -0.9 1.2
Frequency of tiredness / lethargy in last 2 weeks 1.9 3.1 15.7 -4.0 -0.0 0.3 -1.3 -0.9 0.0
Falls in the last year 0.4 0.5 2.0 -1.4 0.5 0.6 -0.2 -0.6 0.4
Hair/balding pattern: Pattern 3 0.5 0.7 2.9 0.5 -0.6 -0.5 0.5 1.7 -0.4
Number of live births 1.3 1.8 2.9 0.9 -1.5 -0.8 -1.3 -1.7 -1.5
Forced expiratory volume in 1-second (FEV1) 0.5 1.7 7.7 -0.5 -0.4 1.1 -0.4 -2.8 -0.6
Pulse rate 3.4 5.8 27.9 0.1 1.5 0.4 1.3 5.3 1.7
Happiness 0.1 0.1 0.6 0.1 0.0 -0.3 -0.7 -0.2 0.1
Noisy workplace 0.3 0.3 0.5 0.2 -0.7 -0.4 -0.6 0.7 -0.7
Qualifications: A levels/AS levels or equivalent 0.3 0.6 2.3 -0.3 -0.5 -0.8 -0.6 1.5 -0.4
Serious illness, injury or assault of a close relative in last 2 years 1.4 1.6 2.6 -1.2 1.3 0.1 1.3 1.6 1.4
Mouth/teeth dental problems: Dentures 1.1 1.8 3.2 -0.2 -1.2 -1.6 -1.8 -1.4 -1.2
Asthma 0.4 0.8 1.8 -1.1 -0.3 -1.3 -1.2 -0.4 -0.2
Medication: Ibuprofen (e.g. Nurofen) 1.0 1.3 3.5 0.1 0.8 1.0 1.9 -1.5 0.7
Medication: Cholesterol lowering 1.6 2.5 4.2 -2.1 -1.4 -1.5 -1.5 1.7 -1.3
Depression (self-reported) 1.9 2.3 7.2 -0.9 -1.3 -0.2 -1.4 -2.7 -1.4
Medication: Lansoprazole 0.3 0.4 1.4 -1.2 0.4 -0.1 -0.3 0.6 0.4
Prospective memory result 0.1 0.1 0.2 0.3 0.4 0.5 -0.2 -0.1 0.2
Lung cancer (father) 1.5 1.7 7.1 -0.3 0.9 1.3 0.1 -2.7 0.8
Illnesses of mother 0.3 0.4 1.0 0.6 -0.3 -1.0 -1.0 -0.2 -0.3
Forced expiratory volume in 1-second (FEV1), Best measure 0.5 1.5 6.9 0.1 -0.6 0.8 -0.4 -2.6 -0.8
Pulse wave Arterial Stiffness index 0.9 1.1 4.5 -2.1 0.3 0.8 0.6 0.8 0.4
Impedance of arm (left) 0.3 1.6 5.7 1.8 -0.4 -0.5 -0.0 2.4 -0.3
Arm fat mass (right) 1.5 6.0 18.6 -4.3 1.8 2.4 -0.4 -2.4 1.7
Trunk predicted mass 1.8 10.5 45.6 -2.7 0.6 3.1 -0.0 -6.8 0.3
Standing height 1.3 12.8 57.5 -1.5 0.5 4.1 0.6 -7.6 0.1
Length of working week for main job 0.2 0.2 0.4 -0.6 0.4 0.4 0.5 -0.3 0.4
Exposure to tobacco smoke at home 0.6 0.6 1.2 -0.9 1.1 0.5 0.3 -0.4 1.1
Breastfed as a baby 0.1 0.1 0.2 0.2 -0.4 -0.2 -0.1 0.0 -0.4
Tense / ‘highly strung’ 1.1 1.9 2.7 -0.4 1.6 1.3 1.3 -1.5 1.6
Seen doctor (GP) for nerves, anxiety, tension or depression 0.4 0.7 2.5 -0.7 -0.5 0.2 -0.6 -1.6 -0.6
Hair/balding pattern: Pattern 4 0.3 0.8 2.6 1.0 0.1 -0.4 1.1 1.6 0.1
Birth weight of first child 0.1 0.2 0.5 0.5 0.3 0.3 0.7 -0.1 0.3
Peak expiratory flow (PEF) 0.4 0.9 3.2 -0.5 0.2 1.8 -0.2 -1.4 0.1
Pulse wave reflection index 0.2 0.2 1.0 -0.2 0.1 0.2 0.2 -1.0 0.2
Ever highly irritable/argumentative for 2 days 0.3 0.3 0.7 -0.0 0.8 0.4 0.7 0.0 0.9
Loud music exposure frequency 0.4 0.5 2.3 -1.5 0.1 -0.3 -0.6 -0.3 0.1
Qualifications: O levels/GCSEs or equivalent 1.0 1.6 2.6 -1.2 -1.6 -0.8 -1.0 -1.2 -1.6
Mouth/teeth dental problems: Bleeding gums 0.2 0.3 0.5 -0.7 0.6 0.1 0.6 -0.1 0.7
Blood clot in the leg (DVT) 1.7 2.1 3.5 0.7 1.9 1.7 1.6 -0.1 1.8
Medication: Paracetamol 1.8 3.0 7.2 -2.7 1.2 1.7 1.8 -1.1 1.2
Headache pain in last month 0.3 0.4 1.5 0.9 0.4 -0.2 1.2 0.1 0.4
Medication for cholesterol, blood pressure or diabetes 0.9 1.4 7.1 2.7 0.5 0.3 0.7 -0.6 0.4
Glaucoma (self-reported) 0.4 0.5 1.4 0.9 0.1 0.6 1.2 -0.7 0.0
Gout (self-reported) 1.5 2.1 9.9 -3.1 -0.8 0.6 0.1 -1.1 -0.8
Hypothyroidism/myxoedema (self-reported) 0.3 0.7 3.1 -0.1 -0.1 0.5 0.8 -1.8 -0.2
Medication: Amlodipine 0.4 0.5 2.0 -0.9 0.1 0.6 0.3 -1.4 0.0
Medication: Ventolin 100micrograms inhaler 0.4 0.6 1.5 1.2 -0.7 -1.1 -0.0 0.1 -0.6
Birth weight 3.0 6.6 11.0 1.4 -3.1 -1.6 -3.1 -2.1 -3.3
Chronic bronchitis/emphysema (mother) 1.0 1.2 3.0 -1.7 0.9 1.3 0.7 -0.6 0.9
High blood pressure (siblings) 0.6 0.9 1.9 -0.4 0.7 1.1 1.4 -0.9 0.7
Forced vital capacity (FVC), Best measure 0.9 3.2 16.6 -0.7 -0.5 0.8 -1.0 -4.1 -0.7
Body fat percentage 0.9 3.7 11.3 -3.4 1.7 2.0 -0.1 -1.2 1.6
Leg fat percentage (right) 0.5 1.9 7.5 -2.7 0.8 1.0 -0.9 -1.0 0.7
Arm fat-free mass (right) 2.4 12.1 41.0 -3.1 1.8 4.0 0.8 -6.4 1.4
Exposure to tobacco smoke outside home 2.6 3.5 6.9 -0.9 2.6 1.9 1.8 -0.4 2.6
Comparative body size at age 10 0.8 2.3 4.8 -0.7 2.2 1.0 1.4 0.6 2.2
Number of full brothers 2.2 2.7 6.6 0.1 -2.5 -0.8 -1.3 -1.2 -2.6
Worry too long after embarrassment 0.8 1.4 2.7 1.1 -1.4 -1.7 -0.5 0.6 -1.3
Seen a psychiatrist for nerves, anxiety, tension or depression 1.1 1.5 6.6 0.9 0.2 0.9 0.7 -2.6 0.1
Wheeze or whistling in the chest in last year 0.4 0.8 1.3 -0.3 -1.1 -1.2 -0.9 -0.2 -1.1
Number of children fathered 1.2 1.3 4.1 -1.3 0.5 1.3 0.4 -2.0 0.5
Reason for reducing amount of alcohol drunk: Health precaution 0.2 0.3 0.9 -0.5 -0.0 -0.1 0.7 1.0 0.0
Age at first live birth 1.2 2.1 8.0 2.8 -1.1 0.0 0.4 -1.4 -1.2
Pulse wave peak to peak time 0.9 1.1 4.1 2.0 -0.2 -0.5 -0.6 -1.4 -0.3
Health satisfaction 1.2 1.6 4.8 -0.9 -0.3 -1.0 -1.7 2.2 -0.3
Shortness of breath walking on level ground 1.8 2.2 5.8 -2.4 -0.3 -1.1 -2.4 0.4 -0.2
Qualifications: College or University degree 0.3 1.0 3.2 1.8 -0.1 -0.5 0.1 1.6 -0.1
Eye problems/disorders: None of the above 1.1 1.2 3.3 0.0 -0.9 -0.9 -1.3 1.8 -0.9
Mouth/teeth dental problems: Loose teeth 0.7 0.8 1.6 -0.8 -0.1 -1.0 -1.2 -1.3 -0.1
Emphysema/chronic bronchitis 0.2 0.2 0.6 -0.3 -0.3 -0.3 -0.7 -0.2 -0.4
Medication for pain relief, constipation, heartburn 2.0 3.4 5.6 2.4 -1.6 -1.8 -2.2 1.4 -1.6
Neck or shoulder pain in last month 3.7 5.2 8.2 -1.0 2.9 2.7 2.1 -1.4 2.9
Medication: Blood pressure 1.8 3.1 11.7 -3.4 1.4 1.4 1.1 0.2 1.4
Angina (self-reported) 0.1 0.2 0.3 0.4 -0.4 0.2 0.4 0.6 -0.4
Migraine (self-reported) 0.2 0.2 1.0 0.2 -0.1 -0.5 -0.1 1.0 -0.0
Medication: Ibuprofen 0.9 1.1 3.2 0.5 1.0 0.9 1.8 -0.6 1.0
Medication: Allopurinol 1.4 1.9 6.3 -2.5 0.4 1.5 1.4 -0.8 0.4
Medication: Omeprazole 1.8 2.2 6.3 -2.5 -1.2 -0.9 -1.8 -0.2 -1.2
Medication: Seretide 50 evohaler 0.3 0.4 0.9 -0.8 -0.4 -0.4 -1.0 0.5 -0.4
Mean time to correctly identify matches 1.4 2.7 5.5 1.5 -1.3 -2.4 -1.8 1.3 -1.3
Heart disease (mother) 0.3 0.4 0.9 -1.0 -0.6 0.5 0.1 -0.4 -0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.5 0.5 2.2 -0.8 0.4 0.3 0.1 1.5 0.5
Whole body fat mass 1.5 6.4 15.2 -3.9 1.9 2.9 0.1 -2.8 1.8
Leg fat mass (right) 1.1 4.2 11.6 -3.4 1.3 2.1 -0.2 -2.4 1.2
Arm predicted mass (right) 2.3 11.9 39.7 -3.0 1.8 4.0 0.9 -6.3 1.5
Pulse rate, automated reading 1.0 3.2 15.2 -1.4 0.9 -0.1 0.2 3.9 1.1
Alcohol intake frequency. 2.7 6.2 12.8 -3.6 2.4 3.0 1.1 -1.6 2.4
Comparative height size at age 10 2.1 11.4 49.7 -2.8 -0.0 3.1 -0.8 -7.0 -0.5
Number of full sisters 0.4 0.5 2.1 0.8 0.2 0.2 0.4 -1.5 0.2
Suffer from ‘nerves’ 0.6 0.9 2.3 1.5 -0.4 -0.7 -0.1 -1.4 -0.4
Overall health rating 1.0 2.2 11.9 -3.4 0.6 0.3 -0.9 -0.1 0.6
Chest pain or discomfort 1.1 1.5 3.3 -1.8 -1.0 -0.6 -1.8 -0.8 -0.9
Had major operations 1.2 1.4 2.8 -1.6 -0.9 -0.8 -1.7 -1.0 -0.8
Age at last live birth 0.6 0.8 3.1 1.8 -0.5 -0.2 0.1 -1.1 -0.5
Family relationship satisfaction 2.8 3.5 6.2 -1.8 -1.6 -1.9 -2.5 1.8 -1.5
Leg pain on walking 0.6 0.7 1.7 -0.8 0.3 -1.1 -0.7 1.3 0.4
Qualifications: NVQ or HND or HNC or equivalent 2.2 2.6 4.5 0.3 2.1 1.7 1.9 -0.1 2.1
Commuting to job workplace: Car/motor vehicle 1.7 1.9 3.7 -0.6 -1.9 -1.3 -1.3 -0.9 -1.9
Illness, injury, bereavement, stress in last 2 years 0.9 1.2 1.8 0.9 -1.3 -0.8 -0.9 1.1 -1.3
Medication: Aspirin 0.8 1.1 1.4 -1.0 1.1 1.2 1.2 -0.2 1.2
Supplements: Vitamin C 0.7 0.8 1.7 0.8 -0.8 -1.3 0.8 0.6 -0.8
Knee pain experienced in last month 0.5 0.8 4.2 -2.0 -0.2 0.2 0.4 -0.7 -0.2
Hypertension (Self-reported) 1.9 5.2 17.7 -4.2 2.1 1.8 1.1 -0.0 2.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.4 0.5 2.8 -1.7 -0.2 -0.1 -0.3 0.0 -0.1
Illnesses of father: Heart disease 1.0 1.4 2.3 -1.3 -1.4 -0.6 -1.5 0.6 -1.3
Illnesses of siblings: Diabetes 0.8 0.9 4.4 -2.1 0.3 0.7 0.7 0.2 0.4
Smoking status: Previous 2.9 4.4 6.9 -1.6 2.4 2.6 1.7 -1.4 2.4
Forced expiratory volume in 1-second (FEV1), predicted 1.1 2.4 3.5 -0.9 1.8 1.9 0.7 -1.8 1.7
Whole body fat-free mass 2.0 11.6 41.1 -3.4 1.4 3.8 0.4 -6.4 1.1
Leg fat-free mass (right) 2.0 10.8 27.1 -4.0 1.9 3.8 0.7 -5.2 1.7
Arm fat percentage (left) 0.9 3.8 13.8 -3.7 1.7 1.6 -0.4 -0.8 1.6
Average weekly red wine intake 1.0 1.5 3.6 1.9 -1.1 -1.1 -0.9 -0.7 -1.1
Handedness (chirality/laterality): Left-handed 1.3 1.5 6.1 2.5 0.6 -0.3 1.4 0.4 0.7
Mood swings 0.1 0.2 1.0 -0.3 0.0 0.1 0.1 -1.0 -0.0
Loneliness, isolation 0.5 0.7 2.6 -0.0 -0.7 -1.6 -1.0 -0.3 -0.6
Long-standing illness, disability or infirmity 1.8 2.7 13.3 -3.6 -0.0 0.4 -1.6 0.3 -0.1
Ever had bowel cancer screening 0.6 0.7 1.3 -0.5 -1.1 -0.5 -0.9 -0.6 -1.1
Diabetes diagnosed by doctor 1.5 2.5 10.0 -3.2 0.2 -0.3 -1.4 1.7 0.3
Ever had stillbirth, spontaneous miscarriage or termination 1.5 1.6 4.5 2.1 -0.7 0.1 0.7 -1.8 -0.8
Friendships satisfaction 0.1 0.1 0.3 -0.1 0.0 0.3 0.1 0.5 0.1
Qualifications: nursing, teaching 0.1 0.1 0.4 -0.2 0.0 -0.0 -0.3 -0.6 -0.0
Commuting to job workplace: Walk 0.3 0.4 1.1 -0.2 0.5 0.5 1.1 0.5 0.5
Eye problems/disorders: Cataract 1.1 1.3 3.3 -1.4 0.8 0.9 0.7 -1.8 0.7
Mouth/teeth dental problems: Mouth ulcers 0.1 0.1 0.7 0.0 -0.2 -0.8 0.3 -0.0 -0.1
Medication for cholesterol 2.5 3.8 4.9 2.0 -2.0 -2.2 -2.2 -0.6 -2.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.7 2.0 3.3 -1.8 1.2 1.5 1.5 -1.2 1.2
Back pain experienced in last month 1.6 2.3 7.6 -2.8 1.1 0.9 0.0 -1.8 1.0
Mineral and other dietary supplements 1.5 2.0 7.0 -1.4 -0.4 -1.5 -2.6 0.8 -0.3
Breast cancer (self-reported) 2.2 2.6 5.6 0.2 1.4 2.2 2.4 -1.4 1.2
Asthma (self-reported) 0.3 0.5 1.1 -1.1 -0.1 -1.1 -0.8 -0.4 -0.1
Osteoporosis (self-reported) 1.3 1.6 5.9 1.6 0.3 -0.2 1.0 2.4 0.3
Osteoarthritis (self-reported) 0.9 1.1 4.4 -2.1 0.4 1.4 0.4 0.3 0.3
Medication: Aspirin 1.2 1.6 2.8 -0.7 1.4 1.3 1.7 -0.2 1.5
Medication: Gliclazide 0.7 0.8 3.6 -0.9 0.0 0.2 -0.1 1.9 0.0
Illnesses of father: None of the above (group 1) 3.2 4.0 8.3 1.2 2.2 2.0 2.9 -1.0 2.1
Smoking status: Current 3.3 5.3 12.5 -0.1 -2.5 -2.4 -3.5 -1.1 -2.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.2 2.5 3.6 0.8 -1.9 -1.7 -1.5 1.3 -1.8
Whole body water mass 2.1 12.1 42.2 -3.5 1.5 3.8 0.3 -6.5 1.1
Leg predicted mass (right) 2.1 11.1 26.6 -4.0 2.1 4.0 0.8 -5.2 1.9
Arm fat mass (left) 1.5 6.0 17.2 -4.2 1.8 2.5 -0.3 -2.5 1.7
Number of self-reported non-cancer illnesses 0.6 1.0 4.0 -2.0 0.5 0.6 0.9 -0.7 0.5
Average weekly champagne plus white wine intake 1.0 1.3 4.9 2.2 -1.0 0.1 0.9 -0.0 -1.1
Miserableness 0.2 0.4 1.8 -1.4 -0.2 -0.4 -0.5 -0.0 -0.1
Guilty feelings 0.5 0.8 4.3 0.3 -0.1 0.4 0.3 -2.1 -0.1
Wears glasses or contact lenses 0.6 0.7 1.4 0.7 -0.7 -1.0 -1.2 0.8 -0.6
Ever taken oral contraceptive pill 1.3 1.5 2.9 0.7 -1.7 -1.2 -0.7 -0.8 -1.7
Hearing aid user 0.1 0.1 0.2 -0.2 0.3 -0.0 0.1 0.5 0.3
Mother’s age at death 1.0 1.3 4.2 2.1 -1.2 -0.7 0.3 0.1 -1.2
Financial situation satisfaction 1.0 1.2 2.7 0.4 1.6 0.9 0.9 0.5 1.6
Tinnitus: Yes, now most or all of the time 0.3 0.4 1.3 -1.1 0.6 0.1 0.4 0.1 0.6
Commuting to job workplace: Public transport 4.2 5.1 10.3 0.6 3.1 1.6 2.5 1.0 3.2
Eye problems/disorders: Glaucoma 0.4 0.4 0.9 0.9 -0.7 -0.4 0.1 -0.7 -0.8
Medication: Blood pressure 1.9 3.6 10.8 -3.3 1.6 2.1 1.0 -0.1 1.6
Pain type(s) experienced in last month: Hip pain 0.4 0.5 2.9 -0.1 -0.1 0.5 0.3 -1.7 -0.2
Supplements: Fish oil (including cod liver oil) 0.5 0.7 2.1 -0.2 -0.0 1.2 1.5 -0.7 -0.1
High cholesterol (Self-reported) 0.2 0.4 2.0 -1.4 0.1 -0.4 0.3 -0.1 0.2
Medication: Bendroflumethiazide 0.9 1.4 5.6 -2.4 1.0 0.8 0.6 0.2 1.0
Medication: Paracetamol 0.9 1.3 3.8 -1.9 0.8 1.0 1.4 -0.2 0.8
Medication: Lisinopril 0.8 1.0 3.5 -0.0 0.6 1.2 1.9 -0.0 0.6
Medication: Atorvastatin 0.6 0.7 2.6 -1.1 0.4 0.3 0.3 1.6 0.5
Illnesses of father: High blood pressure 0.7 0.9 1.5 -0.9 1.2 0.8 0.8 0.5 1.2
Alcohol drinker status: Never 0.2 0.2 0.5 -0.7 0.1 0.2 0.3 -0.7 0.1
Ever smoked 0.7 1.2 6.2 -0.2 0.4 0.8 -0.2 -2.5 0.3
Basal metabolic rate 2.2 12.3 38.4 -3.8 1.8 4.0 0.4 -6.2 1.4
Leg fat percentage (left) 0.6 2.2 8.2 -2.9 1.0 1.1 -0.6 -1.1 1.0
Arm fat-free mass (left) 2.1 10.9 39.8 -3.1 1.5 3.5 0.3 -6.3 1.2
Number of operations (self-reported) 0.7 1.0 2.4 -1.4 -0.6 0.3 -1.1 -1.5 -0.6
Average weekly beer plus cider intake 0.4 0.6 1.8 -0.1 -0.4 -1.3 -1.2 0.4 -0.3
Irritability 2.4 4.1 8.5 0.6 1.6 2.6 2.2 -2.9 1.4
Risk taking 0.3 0.4 0.8 0.7 -0.5 -0.9 -0.9 0.4 -0.4
Ever had prostate specific antigen (PSA) test 0.4 0.5 1.8 0.4 -0.2 0.5 0.8 -1.4 -0.2
Fractured/broken bones in last 5 years 0.3 0.4 0.6 0.6 -0.5 -0.2 -0.8 0.7 -0.6
Age started oral contraceptive pill 0.9 1.1 4.1 2.0 -0.1 -1.2 -0.6 0.8 -0.1
Diastolic blood pressure, automated reading 1.8 5.6 16.2 -4.0 1.8 3.1 1.0 -0.7 1.7
Ever depressed for a whole week 0.2 0.3 0.6 -0.3 0.7 -0.0 0.6 0.3 0.8
Unable to work because of sickness or disability 0.4 0.5 1.3 -0.1 -0.5 -0.6 -0.9 -1.1 -0.6
Commuting to job workplace: Cycle 0.9 1.1 3.1 1.0 0.6 0.9 1.8 0.9 0.5
Myopia 0.5 0.8 1.4 -0.3 1.1 0.4 1.2 0.7 1.2
Vascular/heart problems diagnosed by doctor 1.6 4.4 10.6 3.3 -2.1 -1.9 -1.5 -0.3 -2.2
Cholesterol lowering medication 1.3 2.0 3.0 -1.0 1.6 1.5 1.7 -0.4 1.7
Medication: Omeprazole (e.g. Zanprol) 1.0 1.2 3.1 -1.7 -1.0 -0.5 -1.3 -0.7 -1.0
Pain experienced in last month 0.7 1.2 5.8 2.4 0.5 0.1 0.2 1.0 0.5
Supplements: Calcium 0.2 0.2 0.9 -1.0 0.2 0.3 0.3 -0.4 0.1
Basal cell carcinoma (self-reported) 2.4 2.8 6.4 0.5 1.9 1.7 2.5 -0.6 1.9
Heart attack/myocardial infarction (self-reported) 0.7 0.9 1.7 -0.9 -1.0 -0.8 -1.3 0.6 -0.9
Deep venous thrombosis (DVT) (self-reported) 2.4 3.1 5.1 0.6 2.3 2.0 2.0 -0.0 2.2
Heart disease (siblings) 0.2 0.2 0.5 -0.7 -0.6 0.0 -0.1 0.1 -0.5
Alcohol drinker status: Previous 1.3 1.4 8.4 -2.9 0.2 0.3 0.1 -0.2 0.2
Pack years of smoking 0.6 0.9 2.4 -1.0 -0.3 -0.7 -1.2 -1.6 -0.3
Impedance of whole body 0.5 2.8 8.9 3.0 -0.8 -1.1 -0.3 2.3 -0.7
Leg fat mass (left) 1.3 5.0 13.5 -3.7 1.5 2.3 -0.1 -2.7 1.3
Arm predicted mass (left) 1.9 9.6 37.3 -2.8 1.1 3.2 0.1 -6.1 0.8