Hub : Genes

CAPN1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.1241	0.0447	0.00028	0.124	NA	0.093	NA	0.113	6.1e-10	NA	1.0e-07	NA	3.8e-09
2	GTEx	Colon Transverse	0.2050	0.0760	0.00370	0.167	NA	0.090	NA	0.133	2.4e-08	NA	4.7e-05	NA	6.9e-07
3	METSIM	Adipose	0.1934	0.0399	0.00000	0.129	0.157	0.160	0.162	0.157	1.0e-18	8.5e-23	3.7e-23	1.6e-23	8.0e-23
4	YFS	Blood	0.2256	0.0348	0.00000	0.141	0.182	0.196	0.200	0.195	6.9e-44	3.7e-57	5.8e-62	3.6e-63	1.1e-61
5	TCGA	Lung Squamous Cell Carcinoma	0.0324	0.0162	0.00066	0.023	0.020	0.015	NA	0.016	1.1e-03	2.1e-03	7.1e-03	NA	5.1e-03
6	TCGA	Prostate Adenocarcinoma	0.0441	0.0221	0.00049	0.056	0.024	0.027	NA	0.044	1.5e-06	1.2e-03	7.8e-04	NA	2.2e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.4	0.6	0.9	0.2	-1.0	-0.7	-0.9	0.7	-1.0
Bipolar Disorder or Schizophrenia	0.7	1.6	2.2	1.1	-1.2	-1.5	-1.4	1.2	-1.2
Depressed Affect (Nagel 2018)	0.3	0.6	2.3	-0.2	0.4	0.7	0.6	-1.5	0.3
Depression (Nagel 2018)	0.2	0.3	1.4	0.0	0.2	0.3	0.3	-1.2	0.2
Intelligence (Savage-Jansen 2018)	0.3	0.8	3.0	-1.7	-0.3	-0.3	-0.8	-1.1	-0.3
Neuroticism (Nagel 2018)	0.3	0.7	3.8	0.4	0.2	0.3	0.0	-2.0	0.2
Schizophrenia (2018)	0.5	1.1	1.8	1.2	-0.8	-1.3	-1.0	1.0	-0.8
Schizophrenia vs Biploar Disorder	0.4	0.5	1.5	-0.3	-0.6	-0.8	-1.2	0.6	-0.6
Worry (Nagel 2018)	0.5	1.0	3.6	0.4	-0.7	-0.5	-1.1	-1.9	-0.7
Alzheimer’s Disease (in mother)	0.3	0.4	1.0	0.5	-0.6	-0.6	0.4	1.0	-0.6
Alzheimer’s Disease (in father)	0.9	1.0	1.8	-0.6	-1.3	-0.5	-0.8	-1.1	-1.3
Alzheimer’s Disease (including proxy)	0.5	0.7	1.3	-0.2	-1.1	-0.9	-0.6	0.5	-1.1
Crohns Disease (2017)	0.3	0.7	1.3	-1.2	1.0	0.6	0.1	-0.5	1.1
Irritable Bowel Disease (IBD)	0.2	0.4	1.2	-1.1	0.5	0.3	-0.7	-0.4	0.6
Ulcerative Colitis (UC)	0.4	0.7	2.5	-0.9	-0.6	-0.2	-1.6	-0.4	-0.5
Major Depression (MDD)	0.3	0.4	1.0	1.0	-0.6	0.0	-0.7	-0.3	-0.6
Reaction Time	0.5	0.9	3.4	0.2	-0.0	-1.0	-1.1	1.8	-0.0
Verbal and Numeric Reasoning (VNR)	0.8	1.9	7.6	-2.8	0.4	0.9	-0.1	-1.7	0.5
Breast Cancer	1.1	2.6	4.8	-2.2	1.8	1.3	1.2	1.1	1.8
Ovarian Cancer	0.3	0.4	0.9	0.4	-0.9	-0.4	-0.6	-0.3	-1.0
Prostate Cancer	0.5	0.7	2.5	-1.6	-0.1	-0.1	-0.7	-1.2	-0.2
Age at First Birth	0.1	0.2	0.5	0.7	-0.4	0.2	-0.4	-0.4	-0.4
Bipolar Disorder (2011)	0.0	0.0	0.1	0.0	0.0	0.0	0.0	-0.0	0.2
Body Mass Index (BMI) (2010)	0.6	0.8	2.1	-0.4	-0.8	-0.5	-1.5	-0.9	-0.9
Coronary Artery Disease (CAD)	2.6	3.1	8.8	0.2	1.8	3.0	1.3	-1.2	1.7
Crohns Disease (2012)	0.5	0.7	1.7	-1.3	-0.8	-0.4	-1.0	-0.7	-0.8
Mean Putamen Volume	2.0	2.2	3.8	1.7	-1.4	-1.6	-0.7	1.9	-1.3
Fasting Glucose	0.7	0.8	1.8	0.1	1.2	-0.3	-0.0	1.2	1.4
HbA1C	1.0	1.1	2.4	1.2	1.5	-0.0	0.4	0.3	1.5
HDL Cholesterol	4.6	7.7	13.4	2.7	-3.7	-2.8	-2.0	-0.3	-3.7
LDL Cholesterol	0.6	1.0	2.1	0.8	-0.8	-1.4	-0.3	1.3	-0.8
Lupus	0.3	0.5	1.1	-1.1	0.5	0.9	0.6	0.4	0.5
Neuroticism (2016)	0.1	0.1	0.4	0.6	-0.2	-0.6	-0.1	-0.1	-0.2
Primary Biliary Cirrhosis	0.2	0.3	1.0	-1.0	-0.2	-0.0	-0.9	-0.2	-0.1
Rheumatoid Arthritis	1.5	2.1	9.6	-0.0	-0.9	-0.1	-1.0	-3.1	-1.0
Schizophrenia (2014)	0.2	0.4	1.7	1.3	-0.4	-0.4	-0.6	0.3	-0.4
Triglycerides	1.8	2.9	5.7	0.5	2.4	1.8	1.6	0.6	2.4
Type 2 Diabetes (T2D) (2012)	0.4	0.4	2.2	0.5	0.1	-0.1	0.2	1.5	-0.0
Ulcerative Colitis	0.5	0.7	1.7	0.0	-0.9	-1.0	-1.3	-0.4	-0.8
Blood Eosinophil Count	1.0	7.7	20.6	0.6	2.6	3.2	4.5	-1.2	2.6
Blood Platelet Count	0.5	5.8	20.2	4.5	-0.1	0.1	3.8	0.0	-0.2
Blood Red Count	0.4	4.1	17.9	-4.2	0.8	0.7	0.2	-2.1	0.9
Blood White Count	0.4	2.9	14.9	-3.9	0.5	0.9	-0.5	0.9	0.6
Heel T-Score	0.2	1.7	7.0	-1.3	0.3	1.1	-0.5	-2.6	0.3
BMI	0.6	3.2	7.7	-2.8	1.8	1.4	-0.1	-1.8	1.8
Height	1.3	24.4	112.4	-1.9	0.7	5.3	1.3	-10.6	0.0
Waist Hip Ratio (WHR)	0.6	2.8	8.5	-1.2	-1.1	-2.2	-2.9	0.5	-0.9
Systolic Blood Pressure	1.8	8.8	13.1	-3.6	3.3	3.6	2.3	-0.3	3.3
Smoking Status	1.4	3.4	11.9	-2.0	1.1	1.5	-0.1	-3.5	1.0
Allergy or Eczema	0.7	2.0	4.1	-0.3	-2.0	-0.9	-1.5	-0.9	-2.0
Cardiovascular Disease	2.1	6.9	18.5	-4.3	2.7	2.3	1.5	0.2	2.8
Hypothyroidism (self reported)	0.5	1.2	2.7	0.2	0.7	1.0	1.6	-1.6	0.7
Respiratory disease	0.2	0.4	1.4	0.7	-0.5	-1.2	-0.6	-0.1	-0.4
Type 2 Diabetes (T2D) (2018)	1.8	3.3	11.2	-3.3	1.4	1.1	-0.2	1.8	1.5
Lung FEV1/FVC ratio	0.1	0.4	1.9	0.2	-0.2	0.4	0.7	1.4	-0.2
Lung FVC	1.2	6.1	15.3	-0.1	-2.4	-1.2	-2.7	-3.9	-2.6
Neuroticism	0.3	0.7	4.0	0.4	0.0	0.1	0.2	-2.0	0.0
Chronotype (morning person)	0.0	0.1	0.2	0.5	0.1	0.1	0.4	0.1	0.0
Hair Pigment	0.1	1.7	3.8	1.4	-1.2	0.4	0.7	-1.9	-1.5
Tanning	0.1	1.5	4.0	0.0	-0.5	-1.7	-2.0	1.3	-0.4
Hand grip strength (left)	1.0	2.5	6.0	-0.5	1.6	2.4	1.7	-1.1	1.5
Number of treatments/medications taken	1.0	1.8	5.6	-2.4	0.8	1.2	1.6	0.3	0.8
Average weekly spirits intake	0.5	0.6	2.1	-1.5	0.1	0.9	0.4	0.4	0.0
Sensitivity / hurt feelings	0.1	0.2	0.4	0.3	0.6	0.4	0.6	-0.1	0.6
Frequency of depressed mood in last 2 weeks	0.3	0.4	0.9	-0.8	-0.5	-0.7	-0.9	-0.1	-0.5
Hearing difficulty/problems: Yes	0.3	0.5	2.1	0.2	-0.2	-1.5	-0.3	0.7	-0.2
Relative age of first facial hair	1.0	2.1	3.6	-0.4	1.9	1.5	1.0	1.4	1.9
Other serious medical condition/disability diagnosed by doctor	1.6	2.1	11.0	-3.3	0.4	1.0	-0.3	-0.7	0.4
Ever used hormone-replacement therapy (HRT)	1.6	2.0	3.0	1.2	-1.5	-1.5	-1.7	-0.9	-1.6
Ever had hysterectomy (womb removed)	0.3	0.3	0.8	-0.9	0.3	0.1	-0.8	-0.7	0.2
Systolic blood pressure, automated reading	1.0	2.9	6.1	-2.5	1.4	2.3	1.3	-0.6	1.4
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.2	0.5	-0.1	-0.4	-0.0	0.1	-0.1
Angina	0.2	0.2	0.4	0.6	-0.7	0.1	0.3	0.5	-0.6
Medication for hormone replacement therapy	1.7	2.0	3.1	0.0	1.7	1.5	1.6	0.9	1.8
Vitamin and mineral supplements	0.4	0.6	1.8	0.4	-0.1	-0.4	-1.1	-1.4	-0.1
Supplements: Zinc	0.7	0.8	2.2	0.6	0.3	-0.0	1.3	1.5	0.4
Medication: Co-codamol	1.0	1.2	2.4	-1.0	1.1	1.6	1.1	-0.2	1.1
Medication: Metformin	1.3	1.8	8.3	-2.9	0.4	0.1	-1.2	0.8	0.5
Diabetes (father)	0.4	0.4	1.2	-0.9	-0.3	-0.2	-1.1	0.6	-0.3
Diabetes (mother)	1.1	1.4	3.2	-1.8	1.3	0.5	1.2	-0.0	1.4
Severe depression (siblings)	0.2	0.3	0.9	0.9	-0.5	-0.3	0.1	-0.2	-0.6
Pack years adult smoking proportion	0.4	0.6	1.7	-0.9	0.1	-0.5	-1.0	-1.3	0.1
Impedance of leg (right)	0.6	3.1	11.9	3.5	-1.3	-1.4	-0.5	1.0	-1.3
Leg fat-free mass (left)	2.1	11.0	26.1	-4.1	2.0	3.9	0.6	-5.1	1.7
Trunk fat percentage	1.2	4.8	10.3	-3.2	2.1	2.6	0.4	-1.6	2.0
Hand grip strength (right)	1.8	5.0	9.8	-2.0	2.3	3.1	2.0	-1.5	2.2
Townsend deprivation index at recruitment	1.5	2.1	5.1	-2.1	-0.6	-1.4	-2.3	-0.3	-0.5
Current tobacco smoking	3.1	5.1	11.8	-0.0	-2.5	-2.3	-3.4	-1.0	-2.5
Average weekly fortified wine intake	0.8	1.0	2.2	1.3	0.7	1.0	1.5	-0.3	0.6
Maternal smoking around birth	3.0	4.3	8.7	-1.4	2.9	2.1	1.5	-0.5	3.0
Fed-up feelings	1.8	3.3	5.2	-1.1	1.8	2.3	2.1	-1.5	1.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.4	-0.0	-0.1	-0.6	-0.6	-0.3	-0.1
Relative age voice broke	0.9	1.3	6.1	-0.2	0.9	0.5	0.1	2.5	0.9
Taking other prescription medications	2.0	3.1	14.0	-3.7	0.6	1.2	0.5	-1.4	0.6
Age when periods started (menarche)	0.2	0.5	1.5	1.2	0.3	0.2	0.5	1.1	0.3
Bilateral oophorectomy (both ovaries removed)	0.2	0.3	0.7	0.2	0.8	-0.1	-0.2	0.5	0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	0.9	0.1	0.4	0.8	1.0	-0.7	0.5
Tinnitus: Yes, but not now, but have in the past	0.5	0.6	2.5	0.6	-0.1	0.5	0.4	-1.6	-0.1
Qualifications: CSEs or equivalent	2.4	3.2	5.8	-0.4	1.7	2.4	1.7	-2.3	1.5
Serious illness, injury or assault to yourself	0.5	0.6	2.2	-1.5	0.2	0.5	-1.0	-0.3	0.1
High blood pressure	1.7	4.7	14.2	-3.8	2.1	1.6	1.2	0.3	2.2
Hayfever, allergic rhinitis or eczema	0.3	0.6	1.3	0.8	-1.1	-0.3	-0.2	-0.7	-1.1
Multivitamins +/- minerals	0.7	0.8	2.2	0.3	0.2	1.2	1.5	1.1	0.2
Stomach or abdominal pain in last month	0.2	0.2	0.5	-0.5	0.3	0.7	-0.1	-0.6	0.3
Supplements: Glucosamine	1.2	1.6	4.6	1.7	0.5	1.0	2.1	-0.9	0.5
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	1.9	-0.2	0.9	0.8	0.8	1.4	1.0
Medication: Atenolol	2.5	3.2	7.6	0.2	1.7	2.1	2.8	1.0	1.7
Medication: Levothyroxine sodium	0.6	1.1	1.9	0.6	-1.2	-1.2	-0.2	-1.4	-1.2
Sitting height	0.4	3.1	12.6	-1.7	0.1	1.8	-0.2	-3.5	-0.1
Chronic bronchitis/emphysema (father)	1.6	1.8	3.5	-0.1	-1.3	-1.9	-1.7	1.1	-1.2
High blood pressure (mother)	1.1	1.6	3.0	-0.3	1.4	1.7	1.4	-0.6	1.4
Body mass index (BMI)	1.2	5.1	15.6	-4.0	2.0	2.0	0.0	-1.8	1.9
Impedance of leg (left)	0.6	2.8	11.7	3.4	-1.1	-1.3	-0.2	1.1	-1.1
Leg predicted mass (left)	2.1	10.9	26.6	-4.0	2.0	3.9	0.6	-5.2	1.7
Trunk fat mass	1.7	7.4	15.5	-3.9	2.2	3.3	0.4	-3.0	2.0
Waist circumference	1.7	6.3	17.1	-4.1	1.7	2.4	-0.4	-3.1	1.6
Number of incorrect matches in round	0.8	1.3	4.8	1.5	0.4	0.6	2.2	0.0	0.3
Past tobacco smoking	1.5	2.7	5.7	1.5	-1.6	-1.8	-0.6	2.4	-1.5
Alcohol usually taken with meals	0.9	1.5	4.3	2.1	0.6	0.7	1.3	-1.4	0.5
Nervous feelings	0.2	0.4	1.3	0.6	-0.5	-1.1	-0.3	-0.6	-0.4
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	1.5	0.4	0.3	0.6	0.6	-1.2	0.3
Hearing difficulty/problems with background noise	0.9	1.4	3.2	0.1	-1.5	-1.8	-0.9	-0.1	-1.4
Hair/balding pattern: Pattern 2	0.7	0.9	2.2	0.2	-0.6	-0.8	-1.3	-1.5	-0.7
Had menopause	1.7	2.1	5.6	2.4	-1.3	-1.3	-1.1	-0.7	-1.4
Had other major operations	0.6	0.8	1.8	-1.4	-0.1	0.9	-0.5	-1.3	-0.1
Forced vital capacity (FVC)	0.9	3.6	17.1	-1.1	-0.6	1.1	-1.0	-4.1	-0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	1.0	-0.0	0.4	1.0	0.8	-0.7	0.4
Ever unenthusiastic/disinterested for a whole week	0.4	0.4	1.5	-0.9	0.4	-0.0	0.1	1.2	0.4
Qualifications: None of the above	0.3	0.7	1.6	-1.3	0.1	0.1	-1.2	-0.9	0.1
Financial difficulties in last 2 years	0.8	1.0	2.1	-0.1	1.4	0.9	0.8	-0.8	1.4
Mouth/teeth dental problems	0.4	0.7	1.6	0.1	0.5	1.2	0.8	1.3	0.4
Heart attack	0.7	0.9	1.8	-0.8	-1.0	-1.0	-1.3	0.6	-0.8
Allergy	0.1	0.3	1.4	-0.2	0.3	-0.3	0.0	1.2	0.3
Pain all over the body in last month	0.1	0.1	0.4	-0.6	0.3	0.3	-0.1	-0.4	0.3
Diabetes (self-reported)	1.3	2.1	8.4	-2.9	0.5	0.1	-0.3	1.8	0.6
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	2.6	-0.4	-0.7	-0.8	-0.8	-1.6	-0.7
Medication: Ramipril	0.8	1.1	5.0	-2.2	-0.3	0.7	-0.6	0.6	-0.3
Medication: Simvastatin	0.3	0.4	1.9	-1.4	0.0	0.0	0.0	0.6	0.1
Fluid intelligence score	0.6	1.2	2.1	-1.5	1.1	1.4	0.7	-0.3	1.1
Illnesses of siblings	0.4	0.6	2.2	0.3	-0.3	-0.9	-1.5	0.6	-0.3
Neuroticism score	0.2	0.5	2.0	0.4	0.2	0.2	0.8	-1.4	0.2
Weight	2.2	10.8	23.7	-4.4	2.1	3.7	0.3	-4.9	1.8
Impedance of arm (right)	0.5	2.5	6.3	2.1	-1.0	-1.3	-0.7	2.5	-0.9
Arm fat percentage (right)	0.8	3.2	13.5	-3.7	1.3	1.2	-0.8	-0.6	1.3
Trunk fat-free mass	1.9	10.7	45.2	-2.7	0.8	3.3	0.1	-6.7	0.4
Hip circumference	2.7	11.4	21.3	-4.1	2.6	4.6	1.6	-4.0	2.4
Time employed in main current job	1.0	1.1	2.3	1.5	-1.3	-0.8	-0.3	-0.5	-1.3
Alcohol intake versus 10 years previously	3.7	5.6	8.4	-1.5	2.9	2.8	2.0	-1.6	2.8
Father’s age at death	1.6	2.2	5.1	0.8	1.6	1.5	2.2	-0.4	1.6
Worrier / anxious feelings	0.8	1.5	3.0	1.2	1.2	0.8	1.7	-0.9	1.2
Frequency of tiredness / lethargy in last 2 weeks	1.9	3.1	15.7	-4.0	-0.0	0.3	-1.3	-0.9	0.0
Falls in the last year	0.4	0.5	2.0	-1.4	0.5	0.6	-0.2	-0.6	0.4
Hair/balding pattern: Pattern 3	0.5	0.7	2.9	0.5	-0.6	-0.5	0.5	1.7	-0.4
Number of live births	1.3	1.8	2.9	0.9	-1.5	-0.8	-1.3	-1.7	-1.5
Forced expiratory volume in 1-second (FEV1)	0.5	1.7	7.7	-0.5	-0.4	1.1	-0.4	-2.8	-0.6
Pulse rate	3.4	5.8	27.9	0.1	1.5	0.4	1.3	5.3	1.7
Happiness	0.1	0.1	0.6	0.1	0.0	-0.3	-0.7	-0.2	0.1
Noisy workplace	0.3	0.3	0.5	0.2	-0.7	-0.4	-0.6	0.7	-0.7
Qualifications: A levels/AS levels or equivalent	0.3	0.6	2.3	-0.3	-0.5	-0.8	-0.6	1.5	-0.4
Serious illness, injury or assault of a close relative in last 2 years	1.4	1.6	2.6	-1.2	1.3	0.1	1.3	1.6	1.4
Mouth/teeth dental problems: Dentures	1.1	1.8	3.2	-0.2	-1.2	-1.6	-1.8	-1.4	-1.2
Asthma	0.4	0.8	1.8	-1.1	-0.3	-1.3	-1.2	-0.4	-0.2
Medication: Ibuprofen (e.g. Nurofen)	1.0	1.3	3.5	0.1	0.8	1.0	1.9	-1.5	0.7
Medication: Cholesterol lowering	1.6	2.5	4.2	-2.1	-1.4	-1.5	-1.5	1.7	-1.3
Depression (self-reported)	1.9	2.3	7.2	-0.9	-1.3	-0.2	-1.4	-2.7	-1.4
Medication: Lansoprazole	0.3	0.4	1.4	-1.2	0.4	-0.1	-0.3	0.6	0.4
Prospective memory result	0.1	0.1	0.2	0.3	0.4	0.5	-0.2	-0.1	0.2
Lung cancer (father)	1.5	1.7	7.1	-0.3	0.9	1.3	0.1	-2.7	0.8
Illnesses of mother	0.3	0.4	1.0	0.6	-0.3	-1.0	-1.0	-0.2	-0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.5	6.9	0.1	-0.6	0.8	-0.4	-2.6	-0.8
Pulse wave Arterial Stiffness index	0.9	1.1	4.5	-2.1	0.3	0.8	0.6	0.8	0.4
Impedance of arm (left)	0.3	1.6	5.7	1.8	-0.4	-0.5	-0.0	2.4	-0.3
Arm fat mass (right)	1.5	6.0	18.6	-4.3	1.8	2.4	-0.4	-2.4	1.7
Trunk predicted mass	1.8	10.5	45.6	-2.7	0.6	3.1	-0.0	-6.8	0.3
Standing height	1.3	12.8	57.5	-1.5	0.5	4.1	0.6	-7.6	0.1
Length of working week for main job	0.2	0.2	0.4	-0.6	0.4	0.4	0.5	-0.3	0.4
Exposure to tobacco smoke at home	0.6	0.6	1.2	-0.9	1.1	0.5	0.3	-0.4	1.1
Breastfed as a baby	0.1	0.1	0.2	0.2	-0.4	-0.2	-0.1	0.0	-0.4
Tense / ‘highly strung’	1.1	1.9	2.7	-0.4	1.6	1.3	1.3	-1.5	1.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.7	2.5	-0.7	-0.5	0.2	-0.6	-1.6	-0.6
Hair/balding pattern: Pattern 4	0.3	0.8	2.6	1.0	0.1	-0.4	1.1	1.6	0.1
Birth weight of first child	0.1	0.2	0.5	0.5	0.3	0.3	0.7	-0.1	0.3
Peak expiratory flow (PEF)	0.4	0.9	3.2	-0.5	0.2	1.8	-0.2	-1.4	0.1
Pulse wave reflection index	0.2	0.2	1.0	-0.2	0.1	0.2	0.2	-1.0	0.2
Ever highly irritable/argumentative for 2 days	0.3	0.3	0.7	-0.0	0.8	0.4	0.7	0.0	0.9
Loud music exposure frequency	0.4	0.5	2.3	-1.5	0.1	-0.3	-0.6	-0.3	0.1
Qualifications: O levels/GCSEs or equivalent	1.0	1.6	2.6	-1.2	-1.6	-0.8	-1.0	-1.2	-1.6
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	0.5	-0.7	0.6	0.1	0.6	-0.1	0.7
Blood clot in the leg (DVT)	1.7	2.1	3.5	0.7	1.9	1.7	1.6	-0.1	1.8
Medication: Paracetamol	1.8	3.0	7.2	-2.7	1.2	1.7	1.8	-1.1	1.2
Headache pain in last month	0.3	0.4	1.5	0.9	0.4	-0.2	1.2	0.1	0.4
Medication for cholesterol, blood pressure or diabetes	0.9	1.4	7.1	2.7	0.5	0.3	0.7	-0.6	0.4
Glaucoma (self-reported)	0.4	0.5	1.4	0.9	0.1	0.6	1.2	-0.7	0.0
Gout (self-reported)	1.5	2.1	9.9	-3.1	-0.8	0.6	0.1	-1.1	-0.8
Hypothyroidism/myxoedema (self-reported)	0.3	0.7	3.1	-0.1	-0.1	0.5	0.8	-1.8	-0.2
Medication: Amlodipine	0.4	0.5	2.0	-0.9	0.1	0.6	0.3	-1.4	0.0
Medication: Ventolin 100micrograms inhaler	0.4	0.6	1.5	1.2	-0.7	-1.1	-0.0	0.1	-0.6
Birth weight	3.0	6.6	11.0	1.4	-3.1	-1.6	-3.1	-2.1	-3.3
Chronic bronchitis/emphysema (mother)	1.0	1.2	3.0	-1.7	0.9	1.3	0.7	-0.6	0.9
High blood pressure (siblings)	0.6	0.9	1.9	-0.4	0.7	1.1	1.4	-0.9	0.7
Forced vital capacity (FVC), Best measure	0.9	3.2	16.6	-0.7	-0.5	0.8	-1.0	-4.1	-0.7
Body fat percentage	0.9	3.7	11.3	-3.4	1.7	2.0	-0.1	-1.2	1.6
Leg fat percentage (right)	0.5	1.9	7.5	-2.7	0.8	1.0	-0.9	-1.0	0.7
Arm fat-free mass (right)	2.4	12.1	41.0	-3.1	1.8	4.0	0.8	-6.4	1.4
Exposure to tobacco smoke outside home	2.6	3.5	6.9	-0.9	2.6	1.9	1.8	-0.4	2.6
Comparative body size at age 10	0.8	2.3	4.8	-0.7	2.2	1.0	1.4	0.6	2.2
Number of full brothers	2.2	2.7	6.6	0.1	-2.5	-0.8	-1.3	-1.2	-2.6
Worry too long after embarrassment	0.8	1.4	2.7	1.1	-1.4	-1.7	-0.5	0.6	-1.3
Seen a psychiatrist for nerves, anxiety, tension or depression	1.1	1.5	6.6	0.9	0.2	0.9	0.7	-2.6	0.1
Wheeze or whistling in the chest in last year	0.4	0.8	1.3	-0.3	-1.1	-1.2	-0.9	-0.2	-1.1
Number of children fathered	1.2	1.3	4.1	-1.3	0.5	1.3	0.4	-2.0	0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.3	0.9	-0.5	-0.0	-0.1	0.7	1.0	0.0
Age at first live birth	1.2	2.1	8.0	2.8	-1.1	0.0	0.4	-1.4	-1.2
Pulse wave peak to peak time	0.9	1.1	4.1	2.0	-0.2	-0.5	-0.6	-1.4	-0.3
Health satisfaction	1.2	1.6	4.8	-0.9	-0.3	-1.0	-1.7	2.2	-0.3
Shortness of breath walking on level ground	1.8	2.2	5.8	-2.4	-0.3	-1.1	-2.4	0.4	-0.2
Qualifications: College or University degree	0.3	1.0	3.2	1.8	-0.1	-0.5	0.1	1.6	-0.1
Eye problems/disorders: None of the above	1.1	1.2	3.3	0.0	-0.9	-0.9	-1.3	1.8	-0.9
Mouth/teeth dental problems: Loose teeth	0.7	0.8	1.6	-0.8	-0.1	-1.0	-1.2	-1.3	-0.1
Emphysema/chronic bronchitis	0.2	0.2	0.6	-0.3	-0.3	-0.3	-0.7	-0.2	-0.4
Medication for pain relief, constipation, heartburn	2.0	3.4	5.6	2.4	-1.6	-1.8	-2.2	1.4	-1.6
Neck or shoulder pain in last month	3.7	5.2	8.2	-1.0	2.9	2.7	2.1	-1.4	2.9
Medication: Blood pressure	1.8	3.1	11.7	-3.4	1.4	1.4	1.1	0.2	1.4
Angina (self-reported)	0.1	0.2	0.3	0.4	-0.4	0.2	0.4	0.6	-0.4
Migraine (self-reported)	0.2	0.2	1.0	0.2	-0.1	-0.5	-0.1	1.0	-0.0
Medication: Ibuprofen	0.9	1.1	3.2	0.5	1.0	0.9	1.8	-0.6	1.0
Medication: Allopurinol	1.4	1.9	6.3	-2.5	0.4	1.5	1.4	-0.8	0.4
Medication: Omeprazole	1.8	2.2	6.3	-2.5	-1.2	-0.9	-1.8	-0.2	-1.2
Medication: Seretide 50 evohaler	0.3	0.4	0.9	-0.8	-0.4	-0.4	-1.0	0.5	-0.4
Mean time to correctly identify matches	1.4	2.7	5.5	1.5	-1.3	-2.4	-1.8	1.3	-1.3
Heart disease (mother)	0.3	0.4	0.9	-1.0	-0.6	0.5	0.1	-0.4	-0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.5	2.2	-0.8	0.4	0.3	0.1	1.5	0.5
Whole body fat mass	1.5	6.4	15.2	-3.9	1.9	2.9	0.1	-2.8	1.8
Leg fat mass (right)	1.1	4.2	11.6	-3.4	1.3	2.1	-0.2	-2.4	1.2
Arm predicted mass (right)	2.3	11.9	39.7	-3.0	1.8	4.0	0.9	-6.3	1.5
Pulse rate, automated reading	1.0	3.2	15.2	-1.4	0.9	-0.1	0.2	3.9	1.1
Alcohol intake frequency.	2.7	6.2	12.8	-3.6	2.4	3.0	1.1	-1.6	2.4
Comparative height size at age 10	2.1	11.4	49.7	-2.8	-0.0	3.1	-0.8	-7.0	-0.5
Number of full sisters	0.4	0.5	2.1	0.8	0.2	0.2	0.4	-1.5	0.2
Suffer from ‘nerves’	0.6	0.9	2.3	1.5	-0.4	-0.7	-0.1	-1.4	-0.4
Overall health rating	1.0	2.2	11.9	-3.4	0.6	0.3	-0.9	-0.1	0.6
Chest pain or discomfort	1.1	1.5	3.3	-1.8	-1.0	-0.6	-1.8	-0.8	-0.9
Had major operations	1.2	1.4	2.8	-1.6	-0.9	-0.8	-1.7	-1.0	-0.8
Age at last live birth	0.6	0.8	3.1	1.8	-0.5	-0.2	0.1	-1.1	-0.5
Family relationship satisfaction	2.8	3.5	6.2	-1.8	-1.6	-1.9	-2.5	1.8	-1.5
Leg pain on walking	0.6	0.7	1.7	-0.8	0.3	-1.1	-0.7	1.3	0.4
Qualifications: NVQ or HND or HNC or equivalent	2.2	2.6	4.5	0.3	2.1	1.7	1.9	-0.1	2.1
Commuting to job workplace: Car/motor vehicle	1.7	1.9	3.7	-0.6	-1.9	-1.3	-1.3	-0.9	-1.9
Illness, injury, bereavement, stress in last 2 years	0.9	1.2	1.8	0.9	-1.3	-0.8	-0.9	1.1	-1.3
Medication: Aspirin	0.8	1.1	1.4	-1.0	1.1	1.2	1.2	-0.2	1.2
Supplements: Vitamin C	0.7	0.8	1.7	0.8	-0.8	-1.3	0.8	0.6	-0.8
Knee pain experienced in last month	0.5	0.8	4.2	-2.0	-0.2	0.2	0.4	-0.7	-0.2
Hypertension (Self-reported)	1.9	5.2	17.7	-4.2	2.1	1.8	1.1	-0.0	2.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	2.8	-1.7	-0.2	-0.1	-0.3	0.0	-0.1
Illnesses of father: Heart disease	1.0	1.4	2.3	-1.3	-1.4	-0.6	-1.5	0.6	-1.3
Illnesses of siblings: Diabetes	0.8	0.9	4.4	-2.1	0.3	0.7	0.7	0.2	0.4
Smoking status: Previous	2.9	4.4	6.9	-1.6	2.4	2.6	1.7	-1.4	2.4
Forced expiratory volume in 1-second (FEV1), predicted	1.1	2.4	3.5	-0.9	1.8	1.9	0.7	-1.8	1.7
Whole body fat-free mass	2.0	11.6	41.1	-3.4	1.4	3.8	0.4	-6.4	1.1
Leg fat-free mass (right)	2.0	10.8	27.1	-4.0	1.9	3.8	0.7	-5.2	1.7
Arm fat percentage (left)	0.9	3.8	13.8	-3.7	1.7	1.6	-0.4	-0.8	1.6
Average weekly red wine intake	1.0	1.5	3.6	1.9	-1.1	-1.1	-0.9	-0.7	-1.1
Handedness (chirality/laterality): Left-handed	1.3	1.5	6.1	2.5	0.6	-0.3	1.4	0.4	0.7
Mood swings	0.1	0.2	1.0	-0.3	0.0	0.1	0.1	-1.0	-0.0
Loneliness, isolation	0.5	0.7	2.6	-0.0	-0.7	-1.6	-1.0	-0.3	-0.6
Long-standing illness, disability or infirmity	1.8	2.7	13.3	-3.6	-0.0	0.4	-1.6	0.3	-0.1
Ever had bowel cancer screening	0.6	0.7	1.3	-0.5	-1.1	-0.5	-0.9	-0.6	-1.1
Diabetes diagnosed by doctor	1.5	2.5	10.0	-3.2	0.2	-0.3	-1.4	1.7	0.3
Ever had stillbirth, spontaneous miscarriage or termination	1.5	1.6	4.5	2.1	-0.7	0.1	0.7	-1.8	-0.8
Friendships satisfaction	0.1	0.1	0.3	-0.1	0.0	0.3	0.1	0.5	0.1
Qualifications: nursing, teaching	0.1	0.1	0.4	-0.2	0.0	-0.0	-0.3	-0.6	-0.0
Commuting to job workplace: Walk	0.3	0.4	1.1	-0.2	0.5	0.5	1.1	0.5	0.5
Eye problems/disorders: Cataract	1.1	1.3	3.3	-1.4	0.8	0.9	0.7	-1.8	0.7
Mouth/teeth dental problems: Mouth ulcers	0.1	0.1	0.7	0.0	-0.2	-0.8	0.3	-0.0	-0.1
Medication for cholesterol	2.5	3.8	4.9	2.0	-2.0	-2.2	-2.2	-0.6	-2.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.7	2.0	3.3	-1.8	1.2	1.5	1.5	-1.2	1.2
Back pain experienced in last month	1.6	2.3	7.6	-2.8	1.1	0.9	0.0	-1.8	1.0
Mineral and other dietary supplements	1.5	2.0	7.0	-1.4	-0.4	-1.5	-2.6	0.8	-0.3
Breast cancer (self-reported)	2.2	2.6	5.6	0.2	1.4	2.2	2.4	-1.4	1.2
Asthma (self-reported)	0.3	0.5	1.1	-1.1	-0.1	-1.1	-0.8	-0.4	-0.1
Osteoporosis (self-reported)	1.3	1.6	5.9	1.6	0.3	-0.2	1.0	2.4	0.3
Osteoarthritis (self-reported)	0.9	1.1	4.4	-2.1	0.4	1.4	0.4	0.3	0.3
Medication: Aspirin	1.2	1.6	2.8	-0.7	1.4	1.3	1.7	-0.2	1.5
Medication: Gliclazide	0.7	0.8	3.6	-0.9	0.0	0.2	-0.1	1.9	0.0
Illnesses of father: None of the above (group 1)	3.2	4.0	8.3	1.2	2.2	2.0	2.9	-1.0	2.1
Smoking status: Current	3.3	5.3	12.5	-0.1	-2.5	-2.4	-3.5	-1.1	-2.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.2	2.5	3.6	0.8	-1.9	-1.7	-1.5	1.3	-1.8
Whole body water mass	2.1	12.1	42.2	-3.5	1.5	3.8	0.3	-6.5	1.1
Leg predicted mass (right)	2.1	11.1	26.6	-4.0	2.1	4.0	0.8	-5.2	1.9
Arm fat mass (left)	1.5	6.0	17.2	-4.2	1.8	2.5	-0.3	-2.5	1.7
Number of self-reported non-cancer illnesses	0.6	1.0	4.0	-2.0	0.5	0.6	0.9	-0.7	0.5
Average weekly champagne plus white wine intake	1.0	1.3	4.9	2.2	-1.0	0.1	0.9	-0.0	-1.1
Miserableness	0.2	0.4	1.8	-1.4	-0.2	-0.4	-0.5	-0.0	-0.1
Guilty feelings	0.5	0.8	4.3	0.3	-0.1	0.4	0.3	-2.1	-0.1
Wears glasses or contact lenses	0.6	0.7	1.4	0.7	-0.7	-1.0	-1.2	0.8	-0.6
Ever taken oral contraceptive pill	1.3	1.5	2.9	0.7	-1.7	-1.2	-0.7	-0.8	-1.7
Hearing aid user	0.1	0.1	0.2	-0.2	0.3	-0.0	0.1	0.5	0.3
Mother’s age at death	1.0	1.3	4.2	2.1	-1.2	-0.7	0.3	0.1	-1.2
Financial situation satisfaction	1.0	1.2	2.7	0.4	1.6	0.9	0.9	0.5	1.6
Tinnitus: Yes, now most or all of the time	0.3	0.4	1.3	-1.1	0.6	0.1	0.4	0.1	0.6
Commuting to job workplace: Public transport	4.2	5.1	10.3	0.6	3.1	1.6	2.5	1.0	3.2
Eye problems/disorders: Glaucoma	0.4	0.4	0.9	0.9	-0.7	-0.4	0.1	-0.7	-0.8
Medication: Blood pressure	1.9	3.6	10.8	-3.3	1.6	2.1	1.0	-0.1	1.6
Pain type(s) experienced in last month: Hip pain	0.4	0.5	2.9	-0.1	-0.1	0.5	0.3	-1.7	-0.2
Supplements: Fish oil (including cod liver oil)	0.5	0.7	2.1	-0.2	-0.0	1.2	1.5	-0.7	-0.1
High cholesterol (Self-reported)	0.2	0.4	2.0	-1.4	0.1	-0.4	0.3	-0.1	0.2
Medication: Bendroflumethiazide	0.9	1.4	5.6	-2.4	1.0	0.8	0.6	0.2	1.0
Medication: Paracetamol	0.9	1.3	3.8	-1.9	0.8	1.0	1.4	-0.2	0.8
Medication: Lisinopril	0.8	1.0	3.5	-0.0	0.6	1.2	1.9	-0.0	0.6
Medication: Atorvastatin	0.6	0.7	2.6	-1.1	0.4	0.3	0.3	1.6	0.5
Illnesses of father: High blood pressure	0.7	0.9	1.5	-0.9	1.2	0.8	0.8	0.5	1.2
Alcohol drinker status: Never	0.2	0.2	0.5	-0.7	0.1	0.2	0.3	-0.7	0.1
Ever smoked	0.7	1.2	6.2	-0.2	0.4	0.8	-0.2	-2.5	0.3
Basal metabolic rate	2.2	12.3	38.4	-3.8	1.8	4.0	0.4	-6.2	1.4
Leg fat percentage (left)	0.6	2.2	8.2	-2.9	1.0	1.1	-0.6	-1.1	1.0
Arm fat-free mass (left)	2.1	10.9	39.8	-3.1	1.5	3.5	0.3	-6.3	1.2
Number of operations (self-reported)	0.7	1.0	2.4	-1.4	-0.6	0.3	-1.1	-1.5	-0.6
Average weekly beer plus cider intake	0.4	0.6	1.8	-0.1	-0.4	-1.3	-1.2	0.4	-0.3
Irritability	2.4	4.1	8.5	0.6	1.6	2.6	2.2	-2.9	1.4
Risk taking	0.3	0.4	0.8	0.7	-0.5	-0.9	-0.9	0.4	-0.4
Ever had prostate specific antigen (PSA) test	0.4	0.5	1.8	0.4	-0.2	0.5	0.8	-1.4	-0.2
Fractured/broken bones in last 5 years	0.3	0.4	0.6	0.6	-0.5	-0.2	-0.8	0.7	-0.6
Age started oral contraceptive pill	0.9	1.1	4.1	2.0	-0.1	-1.2	-0.6	0.8	-0.1
Diastolic blood pressure, automated reading	1.8	5.6	16.2	-4.0	1.8	3.1	1.0	-0.7	1.7
Ever depressed for a whole week	0.2	0.3	0.6	-0.3	0.7	-0.0	0.6	0.3	0.8
Unable to work because of sickness or disability	0.4	0.5	1.3	-0.1	-0.5	-0.6	-0.9	-1.1	-0.6
Commuting to job workplace: Cycle	0.9	1.1	3.1	1.0	0.6	0.9	1.8	0.9	0.5
Myopia	0.5	0.8	1.4	-0.3	1.1	0.4	1.2	0.7	1.2
Vascular/heart problems diagnosed by doctor	1.6	4.4	10.6	3.3	-2.1	-1.9	-1.5	-0.3	-2.2
Cholesterol lowering medication	1.3	2.0	3.0	-1.0	1.6	1.5	1.7	-0.4	1.7
Medication: Omeprazole (e.g. Zanprol)	1.0	1.2	3.1	-1.7	-1.0	-0.5	-1.3	-0.7	-1.0
Pain experienced in last month	0.7	1.2	5.8	2.4	0.5	0.1	0.2	1.0	0.5
Supplements: Calcium	0.2	0.2	0.9	-1.0	0.2	0.3	0.3	-0.4	0.1
Basal cell carcinoma (self-reported)	2.4	2.8	6.4	0.5	1.9	1.7	2.5	-0.6	1.9
Heart attack/myocardial infarction (self-reported)	0.7	0.9	1.7	-0.9	-1.0	-0.8	-1.3	0.6	-0.9
Deep venous thrombosis (DVT) (self-reported)	2.4	3.1	5.1	0.6	2.3	2.0	2.0	-0.0	2.2
Heart disease (siblings)	0.2	0.2	0.5	-0.7	-0.6	0.0	-0.1	0.1	-0.5
Alcohol drinker status: Previous	1.3	1.4	8.4	-2.9	0.2	0.3	0.1	-0.2	0.2
Pack years of smoking	0.6	0.9	2.4	-1.0	-0.3	-0.7	-1.2	-1.6	-0.3
Impedance of whole body	0.5	2.8	8.9	3.0	-0.8	-1.1	-0.3	2.3	-0.7
Leg fat mass (left)	1.3	5.0	13.5	-3.7	1.5	2.3	-0.1	-2.7	1.3
Arm predicted mass (left)	1.9	9.6	37.3	-2.8	1.1	3.2	0.1	-6.1	0.8