[Hub]/) : Traits : Leg fat-free mass (right) :

chr12:52,800,649-54,539,005

Best TWAS P=2.22e-11 · Best GWAS P=6.21e-10 conditioned to 0.063

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Subcutaneous PRR13 0.13 0.10 lasso 7 0.09 9.2e-08 5.3 -5.8 6.6e-09 0.39 0.38 0.62 FALSE
2 GTEx Artery Aorta SP1 0.14 0.14 lasso 8 0.14 2.2e-08 5.1 5.2 2.1e-07 -0.25 0.53 0.47 FALSE
3 GTEx Artery Aorta PRR13 0.23 0.28 enet 39 0.30 4.3e-17 5.3 -5.9 4.1e-09 0.35 0.28 0.72 FALSE
4 GTEx Artery Coronary SP1 0.17 0.12 lasso 4 0.12 8.6e-05 5.0 6.2 4.1e-10 -0.32 0.18 0.56 FALSE
5 GTEx Artery Tibial PRR13 0.15 0.18 enet 21 0.22 5.4e-17 5.3 -5.4 6.7e-08 0.34 0.22 0.78 FALSE
6 GTEx Breast Mammary Tissue SP1 0.12 0.13 lasso 5 0.08 9.5e-05 4.9 5.8 5.3e-09 -0.24 0.60 0.36 FALSE
7 GTEx Esophagus Gastroesophageal Junction PRR13 0.22 0.16 lasso 4 0.18 3.2e-07 5.3 -6.2 4.4e-10 0.30 0.21 0.31 FALSE
8 GTEx Esophagus Mucosa PRR13 0.08 0.05 lasso 4 0.04 8.3e-04 5.0 -5.2 2.6e-07 0.32 0.19 0.25 FALSE
9 GTEx Esophagus Muscularis PRR13 0.13 0.15 lasso 2 0.14 9.2e-09 5.3 -5.5 5.1e-08 0.26 0.24 0.75 FALSE
10 GTEx Lung PRR13 0.06 0.06 lasso 2 0.03 1.6e-03 5.1 -5.2 2.3e-07 0.25 0.42 0.44 FALSE
11 GTEx Nerve Tibial PRR13 0.17 0.21 lasso 3 0.20 2.7e-14 5.3 -5.3 1.1e-07 0.24 0.22 0.78 FALSE
12 GTEx Skin Sun Exposed Lower leg PRR13 0.22 0.08 lasso 5 0.17 6.5e-14 4.8 -5.7 1.0e-08 0.31 0.46 0.54 FALSE
13 GTEx Thyroid PRR13 0.22 0.18 lasso 9 0.24 4.8e-18 5.0 -5.7 1.5e-08 0.34 0.53 0.47 FALSE
14 METSIM Adipose SOAT2 0.03 0.06 lasso 1 0.05 1.5e-08 5.2 -5.2 1.7e-07 0.11 0.40 0.60 FALSE
15 METSIM Adipose SP7 0.03 0.02 lasso 2 0.01 6.1e-03 5.2 -5.8 7.3e-09 0.13 0.20 0.18 TRUE
16 YFS Blood SP1 0.22 0.17 bslmm 398 0.18 1.4e-56 5.1 5.3 1.1e-07 -0.17 0.39 0.61 FALSE
17 The Cancer Genome Atlas Bladder Urothelial Carcinoma PRR13 0.13 0.04 blup 28 0.07 3.3e-06 5.1 -6.3 3.0e-10 0.60 0.07 0.40 FALSE
18 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma PRR13 0.03 0.03 blup 28 0.04 4.6e-05 5.0 -5.7 1.4e-08 0.40 0.29 0.39 FALSE
19 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma PRR13 0.05 0.03 blup 28 0.04 4.1e-03 5.3 -6.3 3.9e-10 0.56 0.03 0.21 FALSE
20 The Cancer Genome Atlas Brain Lower Grade Glioma PRR13 0.07 0.04 blup 28 0.05 4.7e-06 5.3 -6.7 2.2e-11 0.60 0.25 0.51 TRUE
21 The Cancer Genome Atlas Rectum Adenocarcinoma PCBP2 0.25 0.04 blup 36 0.10 2.3e-03 -6.1 -6.2 7.7e-10 0.68 0.01 0.42 FALSE
22 The Cancer Genome Atlas Thyroid Carcinoma PCBP2 0.04 0.01 enet 6 0.02 4.8e-03 3.8 -6.5 9.6e-11 0.73 0.00 0.67 FALSE