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chr12:52,800,649-54,539,005

Best TWAS P=2.22e-11 · Best GWAS P=6.21e-10 conditioned to 0.063

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	PRR13	0.13	0.10	lasso	7	0.09	9.2e-08	5.3	-5.8	6.6e-09	0.39	0.38	0.62	FALSE
2	GTEx	Artery Aorta	SP1	0.14	0.14	lasso	8	0.14	2.2e-08	5.1	5.2	2.1e-07	-0.25	0.53	0.47	FALSE
3	GTEx	Artery Aorta	PRR13	0.23	0.28	enet	39	0.30	4.3e-17	5.3	-5.9	4.1e-09	0.35	0.28	0.72	FALSE
4	GTEx	Artery Coronary	SP1	0.17	0.12	lasso	4	0.12	8.6e-05	5.0	6.2	4.1e-10	-0.32	0.18	0.56	FALSE
5	GTEx	Artery Tibial	PRR13	0.15	0.18	enet	21	0.22	5.4e-17	5.3	-5.4	6.7e-08	0.34	0.22	0.78	FALSE
6	GTEx	Breast Mammary Tissue	SP1	0.12	0.13	lasso	5	0.08	9.5e-05	4.9	5.8	5.3e-09	-0.24	0.60	0.36	FALSE
7	GTEx	Esophagus Gastroesophageal Junction	PRR13	0.22	0.16	lasso	4	0.18	3.2e-07	5.3	-6.2	4.4e-10	0.30	0.21	0.31	FALSE
8	GTEx	Esophagus Mucosa	PRR13	0.08	0.05	lasso	4	0.04	8.3e-04	5.0	-5.2	2.6e-07	0.32	0.19	0.25	FALSE
9	GTEx	Esophagus Muscularis	PRR13	0.13	0.15	lasso	2	0.14	9.2e-09	5.3	-5.5	5.1e-08	0.26	0.24	0.75	FALSE
10	GTEx	Lung	PRR13	0.06	0.06	lasso	2	0.03	1.6e-03	5.1	-5.2	2.3e-07	0.25	0.42	0.44	FALSE
11	GTEx	Nerve Tibial	PRR13	0.17	0.21	lasso	3	0.20	2.7e-14	5.3	-5.3	1.1e-07	0.24	0.22	0.78	FALSE
12	GTEx	Skin Sun Exposed Lower leg	PRR13	0.22	0.08	lasso	5	0.17	6.5e-14	4.8	-5.7	1.0e-08	0.31	0.46	0.54	FALSE
13	GTEx	Thyroid	PRR13	0.22	0.18	lasso	9	0.24	4.8e-18	5.0	-5.7	1.5e-08	0.34	0.53	0.47	FALSE
14	METSIM	Adipose	SOAT2	0.03	0.06	lasso	1	0.05	1.5e-08	5.2	-5.2	1.7e-07	0.11	0.40	0.60	FALSE
15	METSIM	Adipose	SP7	0.03	0.02	lasso	2	0.01	6.1e-03	5.2	-5.8	7.3e-09	0.13	0.20	0.18	TRUE
16	YFS	Blood	SP1	0.22	0.17	bslmm	398	0.18	1.4e-56	5.1	5.3	1.1e-07	-0.17	0.39	0.61	FALSE
17	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	PRR13	0.13	0.04	blup	28	0.07	3.3e-06	5.1	-6.3	3.0e-10	0.60	0.07	0.40	FALSE
18	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	PRR13	0.03	0.03	blup	28	0.04	4.6e-05	5.0	-5.7	1.4e-08	0.40	0.29	0.39	FALSE
19	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	PRR13	0.05	0.03	blup	28	0.04	4.1e-03	5.3	-6.3	3.9e-10	0.56	0.03	0.21	FALSE
20	The Cancer Genome Atlas	Brain Lower Grade Glioma	PRR13	0.07	0.04	blup	28	0.05	4.7e-06	5.3	-6.7	2.2e-11	0.60	0.25	0.51	TRUE
21	The Cancer Genome Atlas	Rectum Adenocarcinoma	PCBP2	0.25	0.04	blup	36	0.10	2.3e-03	-6.1	-6.2	7.7e-10	0.68	0.01	0.42	FALSE
22	The Cancer Genome Atlas	Thyroid Carcinoma	PCBP2	0.04	0.01	enet	6	0.02	4.8e-03	3.8	-6.5	9.6e-11	0.73	0.00	0.67	FALSE