Best TWAS P=8.27e-10 · Best GWAS P=5.32e-16 conditioned to 8.82e-07
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | CTSS | 0.04 | 0.01 | bslmm | 313 | 0.02 | 5.5e-04 | -4.9 | 5.2 | 2.1e-07 | 0.13 | 0.03 | 0.92 | TRUE |
| 2 | GTEx | Artery Tibial | HIST2H2AA3 | 0.22 | 0.02 | enet | 20 | 0.12 | 1.8e-09 | 7.5 | 5.6 | 2.1e-08 | 0.70 | 0.00 | 1.00 | TRUE |
| 3 | GTEx | Artery Tibial | RP11-196G18.22 | 0.25 | 0.05 | lasso | 5 | 0.07 | 1.8e-06 | 2.4 | 5.4 | 8.4e-08 | 0.78 | 0.01 | 0.99 | FALSE |
| 4 | GTEx | Artery Tibial | RP11-196G18.24 | 0.31 | 0.08 | enet | 26 | 0.10 | 6.1e-08 | 7.5 | 5.4 | 8.3e-08 | 0.72 | 0.00 | 0.99 | FALSE |
| 5 | GTEx | Ovary | SEMA6C | 0.29 | 0.13 | enet | 11 | 0.14 | 2.6e-04 | -4.9 | -5.1 | 2.9e-07 | -0.22 | 0.01 | 0.92 | FALSE |
| 6 | The Cancer Genome Atlas | Breast Invasive Carcinoma | C1orf54 | 0.06 | 0.02 | enet | 13 | 0.02 | 1.2e-05 | 4.9 | -6.1 | 8.3e-10 | -0.15 | 0.00 | 0.95 | TRUE |
| 7 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | C1orf54 | 0.04 | 0.04 | lasso | 2 | 0.03 | 2.0e-04 | 4.9 | -5.1 | 3.0e-07 | -0.10 | 0.00 | 0.98 | FALSE |
| 8 | The Cancer Genome Atlas | Brain Lower Grade Glioma | MRPS21 | 0.13 | 0.13 | enet | 10 | 0.13 | 1.7e-14 | -3.7 | 5.1 | 2.7e-07 | 0.07 | 0.13 | 0.72 | FALSE |