TWAS hub - HIST2H2AA3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.218	0.061	3.0e-07	0.024	NA	0.118	NA	0.075	0.0053	NA	1.8e-09	NA	1.6e-06
2	GTEx	Esophagus Muscularis	0.176	0.070	6.8e-04	0.018	NA	0.028	NA	0.031	0.0280	NA	7.8e-03	NA	5.4e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Impedance of arm (right)	24.3	113.2	204.5	14.3	4.7
Impedance of arm (left)	24.0	111.2	201.6	14.2	4.5
Comparative height size at age 10	19.3	106.1	201.6	14.2	3.2
Standing height	12.2	120.5	240.2	15.5	0.9
Impedance of whole body	11.8	60.0	110.2	10.5	3.1
Height	10.9	210.1	420.2	20.5	0.2
Trunk fat percentage	10.3	41.1	76.0	8.7	2.5
Forced vital capacity (FVC)	9.5	36.6	51.0	7.1	4.7
Trunk fat mass	8.8	37.8	72.5	8.5	1.8
Forced expiratory volume in 1-second (FEV1), predicted	8.8	18.3	35.0	5.9	1.2
Breast Cancer	7.5	18.0	35.8	-6.0	-0.6
Ulcerative Colitis	7.1	10.3	11.2	3.0	3.4
Heel T-Score	6.8	54.1	59.4	7.7	7.0
Forced vital capacity (FVC), Best measure	6.3	22.9	35.0	5.9	3.3
Tense / ‘highly strung’	5.7	9.4	15.4	3.9	1.9
Body fat percentage	5.4	21.1	38.7	6.2	1.9
Forced expiratory volume in 1-second (FEV1)	5.2	17.4	19.8	4.5	3.9
Whole body fat mass	5.1	21.4	40.7	6.4	1.5
Neuroticism (2016)	5.0	7.2	11.4	1.8	3.4
Hair/balding pattern: Pattern 3	4.9	7.2	13.9	-3.7	-0.8
Arm fat percentage (right)	4.6	18.2	31.4	5.6	2.2
Arm fat percentage (left)	4.6	18.4	31.9	5.7	2.2
Bipolar Disorder or Schizophrenia	4.3	10.4	16.2	2.1	4.0
Pain all over the body in last month	4.2	4.5	5.8	-2.4	-1.8
Hypothyroidism/myxoedema (self-reported)	4.2	8.1	10.5	2.4	3.2
Worry (Nagel 2018)	4.0	8.5	9.7	3.1	2.7
Osteoarthritis (self-reported)	4.0	5.2	6.6	-2.6	-2.0
Type 2 Diabetes (T2D) (2012)	3.9	4.5	4.9	2.2	2.0
Bipolar Disorder (2018)	3.8	6.0	7.9	2.0	2.8
Pack years of smoking	3.8	5.6	7.4	-1.9	-2.7
Leg fat-free mass (left)	3.6	19.0	37.9	6.2	0.2
Forced expiratory volume in 1-second (FEV1), Best measure	3.6	11.6	15.0	3.9	2.9
Leg predicted mass (left)	3.5	18.5	37.0	6.1	0.1
Reaction Time	3.4	6.4	11.4	3.4	1.2
Schizophrenia (2014)	3.4	7.5	13.2	1.4	3.6
Pack years adult smoking proportion	3.4	5.2	6.6	-1.9	-2.6
Fasting Glucose	3.3	3.9	5.4	2.3	1.6
Sensitivity / hurt feelings	3.3	5.7	6.9	2.1	2.6
Sitting height	3.3	23.7	46.0	6.8	-1.2
Arm fat mass (right)	3.3	13.4	24.9	5.0	1.4
Angina (self-reported)	3.3	4.3	5.1	2.3	1.9
Lung FEV1/FVC ratio	3.2	16.4	32.6	-5.7	0.4
Arm fat mass (left)	3.2	13.1	24.9	5.0	1.1
Hypothyroidism (self reported)	3.1	7.2	8.9	2.4	3.0
Diabetes (mother)	3.1	4.0	7.0	-1.0	2.6
Weight	3.1	15.2	30.4	5.5	0.3
Angina	3.0	4.0	5.1	2.3	1.7
Serious illness, injury or assault of a close relative in last 2 years	3.0	3.4	6.8	0.0	-2.6
Leg predicted mass (right)	3.0	15.8	31.5	5.6	-0.2
Suffer from ‘nerves’	2.9	4.6	5.0	2.2	2.0
Illness, injury, bereavement, stress in last 2 years	2.9	3.5	5.3	-1.3	2.3
Leg fat-free mass (right)	2.9	15.7	31.4	5.6	-0.2
Supplements: Zinc	2.8	3.0	5.8	0.5	2.4
Eye problems/disorders: Cataract	2.7	3.1	4.5	2.1	1.3
Blood White Count	2.6	19.5	35.0	-2.0	-5.9
Alcohol drinker status: Never	2.6	3.1	5.5	-2.3	-0.9
Lupus	2.5	3.8	7.3	-0.5	2.7
Heel bone mineral density (BMD) T-score, automated (right)	2.5	5.8	8.6	2.9	1.7
Number of children fathered	2.5	2.8	5.6	-2.4	-0.2
Lung FVC	2.4	12.0	23.2	0.9	4.8
Average weekly fortified wine intake	2.4	2.8	4.2	-2.0	-1.2
Pulse wave peak to peak time	2.4	2.9	4.3	2.1	-1.2
Commuting to job workplace: Cycle	2.4	3.0	5.4	-0.7	-2.3
Had other major operations	2.3	2.9	3.8	-1.9	-1.4
Qualifications: None of the above	2.3	4.9	7.5	-2.7	-1.5
Hip circumference	2.3	9.9	19.7	4.4	0.0
Gout (self-reported)	2.3	3.2	6.1	0.5	2.5
Schizophrenia (2018)	2.2	4.6	8.4	1.0	2.9
Bilateral oophorectomy (both ovaries removed)	2.2	2.5	3.9	-2.0	-1.1
Leg pain on walking	2.2	2.8	4.2	-2.0	-1.1
Neuroticism (Nagel 2018)	2.1	5.0	6.1	2.0	2.5
Neuroticism	2.1	5.0	5.9	2.0	2.4
Heel bone mineral density (BMD) T-score, automated (left)	2.1	4.7	6.0	2.4	1.8
Hair/balding pattern: Pattern 4	2.1	5.0	9.4	-3.1	-0.8
Guilty feelings	2.1	3.1	6.0	2.5	0.5
Medication: Paracetamol	2.1	3.3	4.2	-2.0	-1.6
Rheumatoid Arthritis	2.0	2.8	2.9	-1.6	-1.7
Impedance of leg (right)	2.0	9.9	18.7	4.3	1.1
Worrier / anxious feelings	2.0	3.8	5.4	2.3	1.5
Schizophrenia vs Biploar Disorder	1.9	2.5	2.6	-1.5	-1.6
Blood Eosinophil Count	1.9	15.0	27.2	-1.6	-5.2
Medication: Metformin	1.9	2.7	4.5	2.1	0.9
Osteoporosis (self-reported)	1.9	2.3	4.0	2.0	0.9
Mother’s age at death	1.9	2.4	2.9	-1.4	1.7
Medication: Omeprazole (e.g. Zanprol)	1.9	2.4	3.5	-1.1	-1.9
Ulcerative Colitis (UC)	1.8	3.4	5.0	1.3	2.2
Age when periods started (menarche)	1.8	4.4	7.6	-1.1	-2.8
Illnesses of mother	1.8	2.2	3.6	-0.9	-1.9
High blood pressure	1.7	4.8	9.0	-3.0	0.8
Stomach or abdominal pain in last month	1.7	2.1	4.2	0.2	2.0
Lung cancer (father)	1.7	1.9	2.2	-1.5	-1.3
Medication: Omeprazole	1.7	2.1	3.6	-0.7	-1.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.7	3.6	5.5	-1.3	2.4
Basal metabolic rate	1.7	9.2	17.8	4.2	-0.8
Ever depressed for a whole week	1.7	2.1	3.4	0.9	1.9
HDL Cholesterol	1.6	2.7	3.9	-1.2	-2.0
Tinnitus: Yes, but not now, but have in the past	1.6	1.7	3.4	1.9	-0.2
Medication: Levothyroxine sodium	1.6	2.7	3.3	1.8	1.5
Had menopause	1.6	2.0	2.3	1.3	-1.5
Length of working week for main job	1.6	1.8	2.3	-1.5	-1.1
Pulse wave reflection index	1.6	2.0	3.0	-1.7	-1.0
Medication: Ventolin 100micrograms inhaler	1.6	2.1	3.6	0.7	1.9
Qualifications: College or University degree	1.6	5.0	6.0	2.0	2.4
Medication: Blood pressure	1.6	3.1	6.0	-2.5	-0.2
Medication: Bendroflumethiazide	1.6	2.4	3.2	-1.8	-1.3
Ever smoked	1.6	2.8	4.6	2.1	1.0
Coronary Artery Disease (CAD)	1.5	1.8	3.3	0.5	1.8
Illnesses of siblings	1.5	2.0	3.1	-1.0	-1.8
Pulse wave Arterial Stiffness index	1.5	1.7	2.0	-1.4	1.2
Qualifications: O levels/GCSEs or equivalent	1.5	2.4	3.0	1.7	1.3
Medication: Paracetamol	1.5	2.5	4.1	-2.0	-0.9
Hypertension (Self-reported)	1.5	4.2	7.3	-2.7	1.0
Eye problems/disorders: Glaucoma	1.5	1.7	2.7	-0.9	-1.6
Vascular/heart problems diagnosed by doctor	1.5	4.1	7.3	2.7	-0.9
Alzheimer’s Disease (in father)	1.4	1.5	2.6	-0.7	-1.6
Average weekly spirits intake	1.4	1.8	3.4	0.4	-1.9
Ever had hysterectomy (womb removed)	1.4	1.6	1.9	-1.2	-1.4
Serious illness, injury or assault to yourself	1.4	1.6	3.2	0.2	-1.8
Impedance of leg (left)	1.4	6.8	13.0	3.6	0.8
Chronic bronchitis/emphysema (mother)	1.4	1.6	2.8	1.7	0.6
Number of operations (self-reported)	1.4	2.0	2.5	-1.6	-1.2
Pain experienced in last month	1.4	2.4	4.4	2.1	0.7
Body Mass Index (BMI) (2010)	1.3	1.8	1.8	-1.4	-1.4
Diabetes (father)	1.3	1.6	2.0	1.4	1.1
Neuroticism score	1.3	2.7	2.7	1.6	1.6
Mean time to correctly identify matches	1.3	2.4	3.8	2.0	1.0
Breast cancer (self-reported)	1.3	1.6	2.1	1.0	-1.5
Medication: Lisinopril	1.3	1.7	2.7	-1.6	0.8
Supplements: Calcium	1.3	1.5	2.9	1.7	0.1
Alcohol drinker status: Previous	1.3	1.5	3.0	0.1	1.7
Medication: Co-codamol	1.2	1.4	2.7	-1.6	-0.3
Hand grip strength (right)	1.2	3.2	6.4	2.5	-0.3
Time employed in main current job	1.2	1.4	2.1	-0.8	-1.5
Exposure to tobacco smoke at home	1.2	1.4	2.8	-1.7	0.1
Mouth/teeth dental problems: Bleeding gums	1.2	1.5	2.2	1.5	0.9
Supplements: Vitamin C	1.2	1.5	1.8	1.4	1.0
Whole body fat-free mass	1.2	6.9	12.4	3.5	-1.2
Qualifications: nursing, teaching	1.2	1.8	3.2	1.8	0.7
Type 2 Diabetes (T2D) (2018)	1.1	2.0	3.0	1.0	1.7
Hair Pigment	1.1	30.9	34.3	-5.2	-5.9
Multivitamins +/- minerals	1.1	1.4	1.8	1.3	1.0
Diverticular disease/diverticulitis (self-reported)	1.1	1.4	2.7	1.6	0.2
Wheeze or whistling in the chest in last year	1.1	1.9	3.5	-1.9	-0.5
Whole body water mass	1.1	6.6	11.7	3.4	-1.2
Prostate Cancer	1.0	1.4	1.9	-1.4	-1.0
Mean Putamen Volume	1.0	1.1	1.7	1.3	0.7
Qualifications: CSEs or equivalent	1.0	1.3	2.0	1.4	0.7
Past tobacco smoking	1.0	1.8	3.1	-1.8	-0.7
Hair/balding pattern: Pattern 2	1.0	1.3	2.4	1.6	0.4
Peak expiratory flow (PEF)	1.0	2.2	2.7	1.3	1.6
Birth weight	1.0	2.1	4.1	0.3	-2.0
Medication: Seretide 50 evohaler	1.0	1.1	2.1	0.3	-1.5
Leg fat mass (right)	1.0	3.7	7.4	2.7	0.2
Illnesses of siblings: Diabetes	1.0	1.2	1.5	1.2	1.0
Smoking status: Previous	1.0	1.5	2.6	1.6	0.7
Illnesses of father: High blood pressure	1.0	1.2	2.0	0.7	1.4
Chronotype (morning person)	0.9	2.0	3.0	1.7	-1.0
Vitamin and mineral supplements	0.9	1.2	1.7	-1.3	-0.8
Supplements: Glucosamine	0.9	1.2	2.2	-1.5	-0.4
Waist circumference	0.9	3.4	5.8	2.4	1.0
Nervous feelings	0.9	1.7	2.0	1.2	1.4
Knee pain experienced in last month	0.9	1.3	2.5	-1.6	0.4
Medication for cholesterol	0.9	1.4	2.6	1.6	-0.5
Back pain experienced in last month	0.9	1.3	2.4	-1.5	0.5
Average weekly champagne plus white wine intake	0.9	1.2	1.5	1.2	1.0
Ever had prostate specific antigen (PSA) test	0.9	1.1	2.0	-1.4	0.4
Depression (Nagel 2018)	0.8	1.2	1.3	1.2	1.0
Irritable Bowel Disease (IBD)	0.8	1.8	3.0	0.8	1.7
Waist Hip Ratio (WHR)	0.8	3.7	5.7	1.3	2.4
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.3	1.3	1.1	1.1
Heart attack	0.8	1.0	2.0	-0.2	1.4
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.2	2.0	-1.4	0.6
Noisy workplace	0.8	1.0	1.8	-1.3	-0.3
Depression (self-reported)	0.8	0.9	1.4	0.7	1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.3	2.2	0.6	1.5
Comparative body size at age 10	0.8	2.2	4.3	-2.1	-0.3
Average weekly red wine intake	0.8	1.2	1.8	0.7	1.3
Ever had bowel cancer screening	0.8	0.9	1.8	-1.3	0.3
Tinnitus: Yes, now most or all of the time	0.8	0.9	1.9	0.0	1.4
Unable to work because of sickness or disability	0.8	1.0	1.2	-0.9	1.1
Heart attack/myocardial infarction (self-reported)	0.8	1.0	2.0	-0.0	1.4
Leg fat mass (left)	0.8	3.1	6.1	2.5	0.1
Alzheimer’s Disease (including proxy)	0.7	1.1	1.5	-1.2	-0.8
LDL Cholesterol	0.7	1.1	2.2	-1.5	0.2
Primary Biliary Cirrhosis	0.7	1.0	1.3	1.1	0.8
Cardiovascular Disease	0.7	2.4	2.5	-1.5	1.6
Frequency of depressed mood in last 2 weeks	0.7	1.0	1.3	0.8	1.1
Relative age of first facial hair	0.7	1.5	2.5	0.7	-1.6
High blood pressure (mother)	0.7	1.0	1.3	-1.2	0.8
Alcohol usually taken with meals	0.7	1.1	2.1	1.5	-0.1
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	1.0	-0.9	1.0
Trunk fat-free mass	0.7	3.9	4.8	2.2	-1.8
Father’s age at death	0.7	1.0	1.8	-1.4	-0.3
Pulse rate	0.7	1.2	1.3	-1.1	1.1
Medication: Cholesterol lowering	0.7	1.1	1.8	0.5	1.4
Trunk predicted mass	0.7	4.0	5.1	2.2	-1.7
Pulse rate, automated reading	0.7	2.1	3.1	-1.1	1.8
Illnesses of father: Heart disease	0.7	1.0	1.3	0.9	1.1
Diabetes diagnosed by doctor	0.7	1.1	1.6	0.7	1.3
Medication: Gliclazide	0.7	0.8	1.5	-0.3	-1.2
Hearing aid user	0.7	0.8	1.5	1.2	-0.2
Crohns Disease (2012)	0.6	0.9	1.5	1.2	0.6
HbA1C	0.6	0.7	1.3	-0.4	1.1
Blood Red Count	0.6	5.9	9.7	-1.5	-3.1
Hand grip strength (left)	0.6	1.6	2.7	1.6	0.7
Ever used hormone-replacement therapy (HRT)	0.6	0.8	1.3	0.5	-1.2
Eye problems/disorders: Diabetes related eye disease	0.6	0.6	0.9	1.0	0.5
Medication for hormone replacement therapy	0.6	0.6	0.9	0.6	0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.7	1.4	-1.2	-0.3
Relative age voice broke	0.6	0.9	1.8	-0.2	-1.3
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	1.5	-0.2	1.2
Glaucoma (self-reported)	0.6	0.7	1.3	-0.3	-1.1
Exposure to tobacco smoke outside home	0.6	0.8	1.6	-1.3	0.0
Number of full brothers	0.6	0.8	0.8	0.9	0.9
Age at first live birth	0.6	1.1	1.8	0.7	1.3
Chest pain or discomfort	0.6	0.8	1.2	0.7	1.1
Loneliness, isolation	0.6	0.9	1.7	0.2	1.3
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	1.1	-0.3	-1.1
Other serious medical condition/disability diagnosed by doctor	0.5	0.6	1.2	1.1	0.2
Mouth/teeth dental problems	0.5	0.8	0.9	-0.9	-0.8
Arm fat-free mass (right)	0.5	2.7	4.7	0.9	-2.2
Worry too long after embarrassment	0.5	0.8	1.6	0.3	1.3
Heart disease (mother)	0.5	0.6	0.7	0.7	0.8
Arm predicted mass (right)	0.5	2.5	4.3	0.8	-2.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.1	-0.4	-1.1
Handedness (chirality/laterality): Left-handed	0.5	0.7	0.8	0.9	0.7
Illnesses of father: None of the above (group 1)	0.5	0.6	1.1	-1.0	-0.3
Wears glasses or contact lenses	0.5	0.6	0.8	-0.9	-0.6
Commuting to job workplace: Public transport	0.5	0.6	1.0	0.5	1.0
Arm fat-free mass (left)	0.5	2.5	3.5	1.2	-1.9
Average weekly beer plus cider intake	0.5	0.7	1.0	-1.0	0.7
Fractured/broken bones in last 5 years	0.5	0.6	1.2	1.1	-0.0
Arm predicted mass (left)	0.5	2.4	3.7	1.1	-1.9
Major Depression (MDD)	0.4	0.5	0.5	-0.7	0.7
Number of treatments/medications taken	0.4	0.6	1.0	-1.0	0.5
Chronic bronchitis/emphysema (father)	0.4	0.5	0.9	0.9	-0.4
Number of incorrect matches in round	0.4	0.7	1.3	0.4	1.1
Medication: Ramipril	0.4	0.5	0.9	-1.0	-0.1
Medication: Simvastatin	0.4	0.6	0.9	0.9	0.6
Alcohol intake versus 10 years previously	0.4	0.6	0.8	0.7	0.9
Loud music exposure frequency	0.4	0.4	0.8	-0.9	-0.2
Medication: Amlodipine	0.4	0.6	1.2	-0.1	-1.1
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	0.7	0.8	0.6
Health satisfaction	0.4	0.6	1.1	-0.1	1.1
Medication: Blood pressure	0.4	0.8	1.5	-1.2	-0.2
Medication: Allopurinol	0.4	0.5	0.8	-0.5	0.9
Alcohol intake frequency.	0.4	0.9	1.9	-1.4	-0.1
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.0	-1.0	0.2
Commuting to job workplace: Car/motor vehicle	0.4	0.4	0.5	-0.7	-0.5
Friendships satisfaction	0.4	0.5	1.1	1.0	0.0
Mouth/teeth dental problems: Mouth ulcers	0.4	0.7	0.8	-0.8	0.9
Risk taking	0.4	0.6	0.7	0.7	0.8
Myopia	0.4	0.5	0.7	-0.9	0.6
Age at First Birth	0.3	0.4	0.7	-0.9	0.2
Triglycerides	0.3	0.5	0.6	-0.7	0.8
Blood Platelet Count	0.3	3.8	7.3	-2.7	-0.6
Systolic Blood Pressure	0.3	1.6	3.0	0.4	1.7
Respiratory disease	0.3	0.6	1.2	1.1	-0.1
Maternal smoking around birth	0.3	0.4	0.5	0.7	-0.5
Taking other prescription medications	0.3	0.4	0.5	0.6	0.7
Body mass index (BMI)	0.3	1.1	2.1	-1.5	-0.1
Diabetes (self-reported)	0.3	0.4	0.7	0.8	0.5
Number of live births	0.3	0.4	0.6	0.7	0.5
Happiness	0.3	0.4	0.7	0.2	0.9
Prospective memory result	0.3	0.4	0.4	-0.6	0.7
Birth weight of first child	0.3	0.6	0.7	0.7	0.9
High blood pressure (siblings)	0.3	0.4	0.7	0.2	0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	0.7	0.8	0.4
Eye problems/disorders: None of the above	0.3	0.4	0.6	-0.4	-0.8
Medication for pain relief, constipation, heartburn	0.3	0.6	0.8	0.9	0.6
Smoking status: Current	0.3	0.5	0.9	0.4	0.9
Miserableness	0.3	0.5	0.9	-0.1	0.9
Supplements: Fish oil (including cod liver oil)	0.3	0.4	0.7	-0.9	0.2
Medication: Atorvastatin	0.3	0.4	0.6	-0.5	0.8
Heart disease (siblings)	0.3	0.4	0.6	0.8	0.3
BMI	0.2	1.1	2.0	-1.4	-0.3
Smoking Status	0.2	0.5	0.9	0.4	1.0
Tanning	0.2	2.9	5.3	-0.7	-2.3
Systolic blood pressure, automated reading	0.2	0.5	0.9	0.4	0.9
Fed-up feelings	0.2	0.3	0.3	-0.6	0.6
Hayfever, allergic rhinitis or eczema	0.2	0.3	0.7	0.8	0.2
Qualifications: A levels/AS levels or equivalent	0.2	0.4	0.7	0.8	-0.0
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	0.4	-0.6	-0.5
Blood clot in the leg (DVT)	0.2	0.2	0.4	-0.3	0.6
Medication for cholesterol, blood pressure or diabetes	0.2	0.4	0.8	-0.1	-0.9
Mouth/teeth dental problems: Loose teeth	0.2	0.3	0.4	0.7	0.3
Neck or shoulder pain in last month	0.2	0.3	0.5	0.4	0.7
Migraine (self-reported)	0.2	0.2	0.5	0.7	0.1
Medication: Ibuprofen	0.2	0.2	0.4	-0.6	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.4	-0.6	0.2
Number of full sisters	0.2	0.2	0.4	-0.6	0.1
Overall health rating	0.2	0.5	1.0	0.1	1.0
Age at last live birth	0.2	0.2	0.4	0.3	0.6
Mood swings	0.2	0.4	0.6	-0.5	-0.8
Commuting to job workplace: Walk	0.2	0.2	0.4	0.6	0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.3	-0.4	0.5
Number of self-reported non-cancer illnesses	0.2	0.4	0.4	-0.7	0.5
Ever taken oral contraceptive pill	0.2	0.2	0.3	-0.4	-0.5
Age started oral contraceptive pill	0.2	0.3	0.5	0.1	-0.7
Basal cell carcinoma (self-reported)	0.2	0.3	0.5	0.2	-0.7
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.5	-0.2	0.7
Depressed Affect (Nagel 2018)	0.1	0.2	0.3	0.2	0.6
Crohns Disease (2017)	0.1	0.2	0.3	0.2	0.6
Verbal and Numeric Reasoning (VNR)	0.1	0.3	0.4	-0.6	-0.4
Ovarian Cancer	0.1	0.2	0.2	-0.3	0.5
Allergy or Eczema	0.1	0.1	0.2	0.4	-0.3
Severe depression (siblings)	0.1	0.1	0.2	-0.2	0.4
Townsend deprivation index at recruitment	0.1	0.1	0.2	0.3	-0.5
Current tobacco smoking	0.1	0.1	0.2	0.2	0.4
Medication: Atenolol	0.1	0.1	0.2	0.2	-0.4
Hearing difficulty/problems with background noise	0.1	0.1	0.2	-0.2	0.5
Allergy	0.1	0.2	0.4	-0.6	0.1
Fluid intelligence score	0.1	0.2	0.3	0.5	0.5
Mouth/teeth dental problems: Dentures	0.1	0.2	0.3	0.6	0.1
Asthma	0.1	0.2	0.3	0.6	0.3
Medication: Lansoprazole	0.1	0.1	0.1	0.3	0.3
Breastfed as a baby	0.1	0.1	0.2	-0.1	0.4
Ever highly irritable/argumentative for 2 days	0.1	0.2	0.3	0.2	-0.6
Headache pain in last month	0.1	0.1	0.2	-0.2	0.4
Shortness of breath walking on level ground	0.1	0.1	0.3	-0.5	-0.1
Had major operations	0.1	0.2	0.2	-0.4	0.4
Medication: Aspirin	0.1	0.1	0.2	0.4	0.0
Mineral and other dietary supplements	0.1	0.1	0.2	0.4	-0.1
Medication: Aspirin	0.1	0.2	0.2	0.3	0.4
Financial situation satisfaction	0.1	0.1	0.2	-0.0	0.4
Irritability	0.1	0.1	0.1	0.4	0.3
Cholesterol lowering medication	0.1	0.1	0.2	-0.3	-0.4
Intelligence (Savage-Jansen 2018)	0.0	0.0	0.0	-0.2	0.0
Alzheimer’s Disease (in mother)	0.0	0.0	0.0	-0.2	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0
Hearing difficulty/problems: Yes	0.0	0.1	0.1	-0.2	0.3
Financial difficulties in last 2 years	0.0	0.1	0.1	-0.1	-0.3
Falls in the last year	0.0	0.0	0.0	0.1	-0.0
Leg fat percentage (right)	0.0	0.1	0.2	0.5	0.2
Emphysema/chronic bronchitis	0.0	0.0	0.1	-0.1	-0.3
Family relationship satisfaction	0.0	0.0	0.0	-0.2	0.0
Long-standing illness, disability or infirmity	0.0	0.0	0.1	0.3	0.1
Asthma (self-reported)	0.0	0.0	0.0	0.0	0.1
Pain type(s) experienced in last month: Hip pain	0.0	0.0	0.0	-0.1	0.2
High cholesterol (Self-reported)	0.0	0.1	0.1	0.3	0.2
Leg fat percentage (left)	0.0	0.0	0.0	-0.1	0.2
Diastolic blood pressure, automated reading	0.0	0.1	0.3	0.1	0.5

Hub : Genes

HIST2H2AA3

Models

Trait associations