[Hub]/) : Traits : Leg fat-free mass (right) : ← →

chr1:154,238,383-155,910,830

Best TWAS P=3.19e-41 · Best GWAS P=5.15e-39 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
18	GTEx	Skin Sun Exposed Lower leg	ADAM15	0.14	0.09	lasso	4	0.08	6.1e-07	13.1	-13.4	3.2e-41	-0.96	0.00	1.00	TRUE
7	GTEx	Brain Nucleus accumbens basal ganglia	DCST2	0.28	0.04	lasso	5	0.13	2.0e-04	13.1	7.9	3.5e-15	0.69	0.02	0.90	TRUE
30	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	TRIM46	0.03	0.00	blup	33	0.02	3.6e-03	-7.0	-7.4	1.6e-13	-0.11	0.01	0.63	TRUE
15	GTEx	Pancreas	THBS3	0.36	0.14	lasso	6	0.12	1.0e-05	4.1	-7.3	2.1e-13	-0.34	0.18	0.54	TRUE
25	GTEx	Thyroid	MUC1	0.11	0.02	enet	15	0.09	1.5e-07	5.8	6.9	4.5e-12	0.13	0.98	0.00	TRUE
3	GTEx	Artery Aorta	GBAP1	0.31	0.36	enet	22	0.39	1.0e-22	4.5	5.5	2.8e-08	0.05	1.00	0.00	TRUE
32	The Cancer Genome Atlas	Breast Invasive Carcinoma	TRIM46	0.03	0.01	blup	32	0.01	4.9e-03	-7.0	-5.2	1.9e-07	-0.11	0.01	0.27	TRUE
12	GTEx	Esophagus Gastroesophageal Junction	GBAP1	0.22	0.19	enet	6	0.17	6.8e-07	4.4	5.2	2.1e-07	0.08	0.90	0.01	TRUE
39	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	ZBTB7B	0.05	0.06	lasso	2	0.05	1.8e-06	13.1	-13.0	6.6e-39	-1.00	0.00	1.00	FALSE
5	GTEx	Brain Cerebellar Hemisphere	DCST2	0.45	0.10	lasso	6	0.16	6.6e-05	-4.6	10.1	5.2e-24	0.75	0.01	0.96	FALSE
16	GTEx	Pancreas	RP11-263K19.4	0.22	0.06	enet	23	0.05	3.1e-03	4.1	-9.8	1.0e-22	-0.43	0.06	0.49	FALSE
29	ROSMAP	Brain Pre-frontal Cortex	SLC50A1	0.06	0.02	bslmm	331	0.03	4.3e-05	-7.0	-8.0	1.4e-15	-0.27	0.65	0.04	FALSE
28	NTR	Blood	ZBTB7B	0.02	0.02	lasso	1	0.01	5.4e-05	7.5	7.5	4.6e-14	0.67	0.87	0.03	FALSE
14	GTEx	Esophagus Mucosa	MUC1	0.17	0.20	lasso	4	0.18	5.6e-12	-7.0	-6.9	5.2e-12	-0.12	1.00	0.00	FALSE
9	GTEx	Breast Mammary Tissue (Female)	FAM189B	0.05	-0.01	lasso	2	0.00	4.8e-01	-6.9	6.9	7.1e-12	0.09	0.04	0.07	FALSE
24	GTEx	Thyroid	DCST2	0.16	0.12	lasso	2	0.11	6.4e-09	-4.6	6.7	2.5e-11	0.53	0.38	0.62	FALSE
31	The Cancer Genome Atlas	Breast Invasive Carcinoma	LENEP	0.01	0.00	blup	37	0.01	1.6e-03	-4.4	6.6	4.7e-11	0.48	0.02	0.30	FALSE
26	GTEx	Vagina	GBAP1	0.27	0.08	lasso	7	0.17	1.3e-04	-6.6	6.6	5.2e-11	0.09	0.25	0.05	FALSE
20	GTEx	Spleen	SHC1	0.22	0.14	lasso	2	0.08	4.0e-03	-6.6	-6.5	6.6e-11	-0.15	0.14	0.05	FALSE
17	GTEx	Skin Not Sun Exposed Suprapubic	GBAP1	0.15	0.06	lasso	4	0.06	3.6e-04	-7.1	6.4	1.2e-10	0.11	0.54	0.04	FALSE
1	CommonMind	Brain Pre-frontal Cortex	GBAP1	0.04	0.03	blup	337	0.03	8.6e-05	1.7	6.3	3.4e-10	0.05	0.88	0.00	FALSE
27	METSIM	Adipose	DCST2	0.04	0.04	enet	12	0.04	4.3e-07	-4.4	6.2	5.5e-10	0.47	0.86	0.11	FALSE
35	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	MUC1	0.04	0.01	enet	4	0.02	1.3e-03	-7.0	-6.2	6.9e-10	-0.15	0.01	0.65	FALSE
23	GTEx	Testis	MUC1	0.20	0.02	lasso	7	0.07	7.5e-04	-7.1	-6.1	1.2e-09	-0.11	0.27	0.05	FALSE
10	GTEx	Cells Transformed fibroblasts	SLC50A1	0.08	0.07	lasso	6	0.07	3.9e-06	-4.3	-6.0	2.2e-09	-0.07	0.95	0.00	FALSE
36	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	RAG1AP1	0.07	0.00	blup	76	0.00	2.9e-01	-2.6	-6.0	2.2e-09	-0.17	0.02	0.30	FALSE
11	GTEx	Colon Sigmoid	GBAP1	0.16	0.13	enet	8	0.14	8.4e-06	4.5	5.9	4.3e-09	0.09	0.65	0.04	FALSE
6	GTEx	Brain Cerebellum	THBS3	0.17	0.15	enet	6	0.16	2.0e-05	4.1	-5.9	4.7e-09	-0.09	0.49	0.03	FALSE
37	The Cancer Genome Atlas	Brain Lower Grade Glioma	GBAP1	0.03	0.01	blup	26	0.02	1.9e-03	-4.3	5.8	5.3e-09	0.07	0.03	0.86	FALSE
38	The Cancer Genome Atlas	Brain Lower Grade Glioma	RAG1AP1	0.07	0.05	blup	77	0.05	3.8e-06	-7.1	-5.7	9.3e-09	-0.07	0.01	0.99	FALSE
13	GTEx	Esophagus Mucosa	ADAM15	0.11	0.02	enet	16	0.04	1.5e-03	-5.8	-5.7	1.2e-08	-0.43	0.13	0.78	FALSE
8	GTEx	Brain Putamen basal ganglia	DCST2	0.56	0.05	enet	11	0.10	2.8e-03	-4.6	5.6	2.5e-08	0.47	0.18	0.58	FALSE
19	GTEx	Small Intestine Terminal Ileum	GBAP1	0.20	0.13	lasso	10	0.11	1.8e-03	-4.3	5.4	5.8e-08	0.03	0.16	0.07	FALSE
34	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	DCST2	0.04	0.01	blup	50	0.03	2.0e-04	-4.2	-5.3	9.5e-08	-0.37	0.22	0.10	FALSE
2	GTEx	Adipose Subcutaneous	RP11-307C12.11	0.09	0.02	lasso	3	0.02	1.2e-02	-4.5	5.3	9.6e-08	0.25	0.33	0.03	FALSE
33	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	GBAP1	0.10	0.06	enet	9	0.04	5.1e-03	4.5	5.3	1.1e-07	0.02	0.02	0.34	FALSE
21	GTEx	Spleen	GBAP1	0.33	0.23	enet	20	0.28	7.9e-08	4.4	5.3	1.2e-07	0.09	0.84	0.01	FALSE
22	GTEx	Spleen	THBS3	0.23	0.10	enet	17	0.08	4.6e-03	-6.6	-5.3	1.2e-07	-0.07	0.23	0.04	FALSE
41	The Cancer Genome Atlas	Thyroid Carcinoma	GBAP1	0.02	0.01	blup	24	0.02	3.0e-03	4.5	5.3	1.4e-07	0.06	0.01	0.64	FALSE
40	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	GBAP1	0.05	0.04	blup	26	0.04	1.6e-03	4.5	5.2	1.5e-07	0.10	0.01	0.82	FALSE
4	GTEx	Artery Tibial	GBAP1	0.21	0.26	lasso	7	0.26	1.3e-20	4.5	5.2	2.0e-07	0.07	1.00	0.00	FALSE