[Hub]/) : Traits : Leg fat-free mass (right) : ← →

chr16:52,772,129-54,846,383

Best TWAS P=2.68e-40 · Best GWAS P=9.08e-137 conditioned to 4.5e-63

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
35	GTEx	Testis	AKTIP	0.19	0.00	enet	26	0.00	1.9e-01	6.1	13.3	2.7e-40	0.51	0.03	0.40	TRUE
2	CommonMind	Brain Pre-frontal Cortex	FTO	0.11	0.00	bslmm	739	0.02	1.6e-03	-1.3	11.7	7.7e-32	0.38	0.09	0.55	TRUE
41	The Cancer Genome Atlas	Glioblastoma Multiforme	FTO	0.27	0.16	enet	13	0.14	6.7e-05	-2.0	9.3	1.7e-20	0.33	0.11	0.32	TRUE
45	The Cancer Genome Atlas	Testicular Germ Cell Tumors	AKTIP	0.18	-0.01	enet	10	0.08	6.9e-04	-2.3	-5.7	1.1e-08	-0.01	0.01	0.29	TRUE
26	GTEx	Muscle Skeletal	RBL2	0.11	0.00	lasso	5	0.00	2.9e-01	9.3	-11.8	4.3e-32	-0.10	0.28	0.23	FALSE
44	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	RBL2	0.11	0.08	blup	44	0.06	1.5e-03	9.2	-9.1	6.3e-20	-0.03	0.01	0.78	FALSE
39	YFS	Blood	AKTIP	0.19	0.27	lasso	13	0.30	3.3e-99	9.9	9.0	3.3e-19	-0.01	1.00	0.00	FALSE
3	CommonMind	Brain Pre-frontal Cortex	RBL2	0.22	0.24	enet	15	0.26	1.8e-31	6.5	-8.3	7.9e-17	0.02	1.00	0.00	FALSE
12	GTEx	Brain Cortex	RBL2	0.51	0.45	enet	12	0.46	3.5e-14	6.1	-8.3	7.9e-17	0.02	1.00	0.00	FALSE
9	GTEx	Artery Tibial	RBL2	0.16	0.17	enet	11	0.20	2.1e-15	6.6	-8.2	2.5e-16	0.02	1.00	0.00	FALSE
40	The Cancer Genome Atlas	Esophageal Carcinoma	RBL2	0.08	0.04	lasso	3	0.03	4.4e-02	9.9	8.0	1.4e-15	0.00	0.01	0.82	FALSE
20	GTEx	Esophagus Mucosa	RBL2	0.36	0.36	enet	37	0.37	2.9e-26	6.6	-7.7	2.0e-14	0.00	1.00	0.00	FALSE
4	GTEx	Adipose Subcutaneous	RBL2	0.34	0.28	enet	18	0.30	1.0e-24	6.6	-7.6	2.9e-14	0.02	1.00	0.00	FALSE
33	GTEx	Spleen	RBL2	0.59	0.47	enet	51	0.46	3.2e-13	6.6	-7.6	3.6e-14	-0.06	1.00	0.00	FALSE
17	GTEx	Colon Sigmoid	RBL2	0.38	0.37	lasso	12	0.29	8.4e-11	6.6	-7.6	3.9e-14	0.03	1.00	0.00	FALSE
43	The Cancer Genome Atlas	Brain Lower Grade Glioma	RBL2	0.03	0.06	enet	5	0.05	8.2e-07	6.1	-7.6	4.2e-14	0.04	0.83	0.17	FALSE
37	GTEx	Vagina	RBL2	0.41	0.37	enet	13	0.34	1.6e-08	6.7	-7.3	3.3e-13	0.03	0.89	0.01	FALSE
31	GTEx	Skin Not Sun Exposed Suprapubic	RBL2	0.35	0.33	enet	16	0.34	2.6e-19	6.5	-7.2	5.0e-13	0.03	1.00	0.00	FALSE
25	GTEx	Lung	RBL2	0.29	0.37	enet	16	0.35	9.1e-28	6.6	-7.1	9.7e-13	0.03	1.00	0.00	FALSE
27	GTEx	Nerve Tibial	RBL2	0.46	0.52	enet	19	0.53	1.6e-43	6.5	-7.1	1.0e-12	0.04	1.00	0.00	FALSE
10	GTEx	Brain Cerebellar Hemisphere	RBL2	0.55	0.55	enet	20	0.46	2.1e-13	6.6	-7.0	2.2e-12	0.04	1.00	0.00	FALSE
32	GTEx	Skin Sun Exposed Lower leg	RBL2	0.35	0.39	enet	25	0.37	2.9e-32	6.5	-7.0	2.3e-12	0.03	1.00	0.00	FALSE
28	GTEx	Pancreas	RBL2	0.36	0.36	enet	26	0.36	5.9e-16	6.5	-7.0	3.7e-12	0.08	1.00	0.00	FALSE
34	GTEx	Stomach	RBL2	0.33	0.26	enet	20	0.26	8.7e-13	6.6	-6.9	6.7e-12	0.04	1.00	0.00	FALSE
11	GTEx	Brain Cerebellum	RBL2	0.66	0.72	enet	16	0.70	5.7e-28	6.6	-6.8	7.4e-12	0.05	1.00	0.00	FALSE
22	GTEx	Heart Atrial Appendage	RBL2	0.28	0.14	enet	25	0.23	8.6e-11	6.5	-6.8	1.2e-11	0.03	1.00	0.00	FALSE
36	GTEx	Thyroid	RBL2	0.34	0.47	lasso	4	0.45	3.6e-38	6.6	-6.7	1.6e-11	0.04	1.00	0.00	FALSE
29	GTEx	Pituitary	RBL2	0.36	0.39	lasso	6	0.40	4.5e-11	6.6	6.6	3.1e-11	-0.04	0.98	0.00	FALSE
7	GTEx	Artery Aorta	RBL2	0.27	0.21	enet	14	0.19	1.5e-10	6.5	-6.6	3.4e-11	0.04	1.00	0.00	FALSE
30	GTEx	Prostate	RBL2	0.55	0.45	lasso	4	0.45	1.0e-12	6.5	-6.6	3.6e-11	0.04	0.99	0.00	FALSE
5	GTEx	Adipose Visceral Omentum	RBL2	0.30	0.27	lasso	2	0.27	4.3e-14	6.6	-6.6	5.5e-11	0.04	1.00	0.00	FALSE
14	GTEx	Breast Mammary Tissue	RBL2	0.36	0.35	lasso	3	0.36	3.0e-19	6.5	-6.5	5.6e-11	0.04	1.00	0.00	FALSE
15	GTEx	Breast Mammary Tissue (Male)	RBL2	0.40	0.29	lasso	2	0.25	1.4e-06	6.5	-6.5	5.9e-11	0.04	0.60	0.02	FALSE
21	GTEx	Esophagus Muscularis	RBL2	0.36	0.38	enet	10	0.41	6.8e-27	6.5	-6.5	8.1e-11	0.05	1.00	0.00	FALSE
23	GTEx	Heart Left Ventricle	RBL2	0.12	0.11	enet	12	0.08	3.3e-05	6.5	-6.5	9.5e-11	-0.03	0.94	0.01	FALSE
8	GTEx	Artery Coronary	RBL2	0.36	0.33	enet	14	0.27	1.4e-09	6.6	-6.4	1.5e-10	0.05	1.00	0.00	FALSE
19	GTEx	Esophagus Gastroesophageal Junction	RBL2	0.38	0.40	enet	17	0.38	1.1e-14	6.6	-6.4	1.7e-10	0.05	1.00	0.00	FALSE
18	GTEx	Colon Transverse	RBL2	0.59	0.44	enet	13	0.52	4.4e-28	6.6	-6.4	2.0e-10	0.05	1.00	0.00	FALSE
16	GTEx	Breast Mammary Tissue (Female)	RBL2	0.47	0.27	lasso	7	0.20	1.1e-06	6.1	-6.3	3.4e-10	0.04	0.97	0.00	FALSE
6	GTEx	Adrenal Gland	RBL2	0.35	0.27	enet	22	0.25	2.3e-09	6.6	-6.2	4.3e-10	0.04	1.00	0.00	FALSE
38	NTR	Blood	RBL2	0.09	0.11	bslmm	419	0.11	1.1e-33	6.6	-6.2	4.5e-10	0.06	1.00	0.00	FALSE
42	The Cancer Genome Atlas	Brain Lower Grade Glioma	AKTIP	0.04	0.03	blup	42	0.05	1.9e-06	6.5	-6.2	5.9e-10	0.04	0.98	0.01	FALSE
1	CommonMind	Brain Pre-frontal Cortex	AKTIP	0.12	0.09	enet	10	0.08	1.9e-10	6.5	-5.8	5.1e-09	0.07	1.00	0.00	FALSE
24	GTEx	Liver	RBL2	0.38	0.22	enet	21	0.20	4.0e-06	6.6	-5.4	5.4e-08	0.09	0.62	0.02	FALSE
13	GTEx	Brain Frontal Cortex BA9	AKTIP	0.29	0.04	enet	27	0.07	6.3e-03	6.6	-5.3	9.6e-08	0.01	0.13	0.07	FALSE