[Hub]/) : Traits : Leg fat-free mass (right) :

chr2:241,563,169-243,048,760

Best TWAS P=1.82e-11 · Best GWAS P=1.31e-10 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex SEPT2 0.52 0.29 bslmm 377 0.44 2.0e-59 5.2 5.8 4.8e-09 -0.12 0.73 0.27 FALSE
2 GTEx Adipose Subcutaneous SEPT2 0.45 0.36 enet 32 0.43 3.0e-38 5.1 6.5 8.1e-11 -0.08 0.73 0.27 FALSE
3 GTEx Adipose Subcutaneous AC005104.3 0.12 0.03 lasso 5 0.06 1.5e-05 5.1 6.3 3.7e-10 -0.06 0.45 0.18 FALSE
4 GTEx Adipose Visceral Omentum BOK 0.20 0.12 lasso 4 0.12 1.4e-06 -6.4 -6.7 1.8e-11 0.97 0.00 1.00 TRUE
5 GTEx Adipose Visceral Omentum AC005104.3 0.17 0.14 lasso 3 0.09 3.0e-05 5.1 5.2 1.5e-07 -0.04 0.74 0.25 FALSE
6 GTEx Artery Aorta SEPT2 0.60 0.38 lasso 9 0.46 5.8e-28 5.1 5.6 2.1e-08 -0.08 0.74 0.26 FALSE
7 GTEx Artery Aorta AC005104.3 0.10 0.01 lasso 4 0.01 1.6e-01 -3.2 5.5 4.8e-08 -0.20 0.09 0.26 FALSE
8 GTEx Artery Tibial SEPT2 0.58 0.50 lasso 13 0.58 1.4e-55 5.1 5.5 3.5e-08 -0.06 0.73 0.27 FALSE
9 GTEx Artery Tibial AC005104.3 0.18 0.14 lasso 5 0.12 6.7e-10 5.1 5.2 1.9e-07 -0.03 0.74 0.26 FALSE
10 GTEx Brain Frontal Cortex BA9 SEPT2 0.30 -0.01 enet 32 0.02 1.1e-01 5.1 6.3 3.9e-10 -0.13 0.07 0.06 FALSE
11 GTEx Breast Mammary Tissue SEPT2 0.46 0.33 enet 37 0.35 5.2e-19 5.1 6.0 2.5e-09 -0.08 0.73 0.27 FALSE
12 GTEx Breast Mammary Tissue (Male) SEPT2 0.18 0.31 lasso 2 0.29 1.6e-07 5.1 5.1 2.9e-07 -0.03 0.29 0.12 FALSE
13 GTEx Cells Transformed fibroblasts SEPT2 0.34 0.14 lasso 6 0.32 5.5e-25 5.1 6.1 1.1e-09 -0.09 0.73 0.27 FALSE
14 GTEx Colon Sigmoid SEPT2 0.55 0.49 lasso 8 0.48 4.7e-19 5.1 5.4 5.9e-08 -0.05 0.73 0.27 FALSE
15 GTEx Colon Sigmoid AC005104.3 0.26 0.21 lasso 3 0.20 1.9e-07 5.1 5.1 2.9e-07 -0.03 0.65 0.21 FALSE
16 GTEx Esophagus Gastroesophageal Junction SEPT2 0.66 0.38 enet 29 0.50 7.1e-21 5.1 6.7 1.9e-11 -0.08 0.73 0.27 TRUE
17 GTEx Esophagus Mucosa SEPT2 0.59 0.50 enet 37 0.56 2.7e-44 5.1 5.7 1.1e-08 -0.06 0.73 0.27 FALSE
18 GTEx Esophagus Muscularis SEPT2 0.57 0.34 enet 34 0.48 1.7e-32 5.1 5.8 5.3e-09 -0.11 0.74 0.26 FALSE
19 GTEx Heart Atrial Appendage SEPT2 0.26 0.21 lasso 5 0.20 1.7e-09 5.1 5.3 8.8e-08 -0.04 0.73 0.26 FALSE
20 GTEx Heart Atrial Appendage AC114730.11 0.16 0.07 enet 11 0.16 1.2e-07 -3.5 -6.1 1.2e-09 0.28 0.31 0.20 FALSE
21 GTEx Lung SEPT2 0.42 0.33 lasso 6 0.38 2.6e-30 5.1 5.6 2.6e-08 -0.04 0.73 0.27 FALSE
22 GTEx Muscle Skeletal SEPT2 0.39 0.22 enet 46 0.26 1.0e-25 5.1 5.6 1.9e-08 -0.13 0.73 0.27 FALSE
23 GTEx Nerve Tibial SEPT2 0.70 0.52 lasso 11 0.58 1.4e-49 5.1 5.4 5.9e-08 -0.06 0.73 0.27 FALSE
24 GTEx Nerve Tibial AC005104.3 0.28 0.21 enet 19 0.24 4.6e-17 5.1 5.8 7.6e-09 -0.06 0.74 0.26 FALSE
25 GTEx Ovary SEPT2 0.56 0.29 lasso 5 0.23 2.4e-06 5.1 5.8 5.7e-09 -0.06 0.41 0.16 FALSE
26 GTEx Skin Not Sun Exposed Suprapubic SEPT2 0.63 0.38 enet 29 0.42 1.1e-24 5.1 5.9 2.9e-09 -0.08 0.73 0.27 FALSE
27 GTEx Skin Not Sun Exposed Suprapubic AC005104.3 0.27 0.06 enet 24 0.20 5.6e-11 3.8 6.4 1.7e-10 -0.21 0.58 0.06 FALSE
28 GTEx Skin Sun Exposed Lower leg SEPT2 0.55 0.36 lasso 9 0.37 7.6e-32 5.1 5.5 4.0e-08 -0.04 0.73 0.27 FALSE
29 GTEx Stomach SEPT2 0.24 0.27 lasso 8 0.25 3.6e-12 5.1 5.2 2.0e-07 -0.03 0.74 0.26 FALSE
30 GTEx Whole Blood SEPT2 0.26 0.10 lasso 5 0.12 1.8e-11 5.1 6.0 2.7e-09 -0.08 0.73 0.26 FALSE
31 METSIM Adipose BOK 0.06 0.03 lasso 6 0.03 7.8e-06 -6.4 -6.2 7.2e-10 0.95 0.00 1.00 FALSE
32 METSIM Adipose SEPT2 0.29 0.21 bslmm 375 0.20 1.6e-29 5.1 5.5 3.5e-08 -0.04 0.73 0.27 FALSE
33 NTR Blood SEPT2 0.18 0.10 enet 34 0.14 1.0e-43 5.1 6.4 1.6e-10 -0.13 0.74 0.26 FALSE
34 ROSMAP Brain Pre-frontal Cortex SEPT2 0.48 0.39 enet 49 0.42 6.0e-58 5.1 5.7 1.3e-08 -0.10 0.73 0.27 FALSE
35 The Cancer Genome Atlas Breast Invasive Carcinoma SEPT2 0.21 0.02 enet 11 0.07 4.9e-15 2.6 5.5 3.6e-08 -0.10 0.01 0.02 FALSE
36 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma SEPT2 0.19 0.06 enet 9 0.08 1.0e-09 2.6 5.8 5.1e-09 -0.10 0.01 0.03 FALSE
37 The Cancer Genome Atlas Brain Lower Grade Glioma SEPT2 0.51 0.10 enet 14 0.20 2.4e-22 2.6 5.6 2.7e-08 -0.09 0.01 0.03 FALSE
38 The Cancer Genome Atlas Lung Adenocarcinoma SEPT2 0.24 0.04 blup 45 0.08 1.6e-09 2.6 6.2 7.3e-10 -0.12 0.00 0.03 FALSE
39 The Cancer Genome Atlas Pancreatic Adenocarcinoma SEPT2 0.42 0.11 enet 14 0.18 5.2e-08 2.5 5.8 6.4e-09 -0.07 0.00 0.01 FALSE
40 The Cancer Genome Atlas Prostate Adenocarcinoma BOK 0.07 0.04 lasso 5 0.03 1.8e-04 6.1 -5.9 3.6e-09 0.76 0.01 0.98 FALSE
41 The Cancer Genome Atlas Prostate Adenocarcinoma SEPT2 0.40 0.06 enet 14 0.17 8.0e-18 2.6 5.5 2.9e-08 -0.10 0.01 0.03 FALSE
42 The Cancer Genome Atlas Thyroid Carcinoma SEPT2 0.76 0.25 enet 14 0.47 1.8e-50 2.6 5.5 3.6e-08 -0.05 0.01 0.03 FALSE