[Hub]/) : Traits : Leg fat-free mass (right) : ← →

chr4:105,373,669-107,092,169

Best TWAS P=4.3e-20 · Best GWAS P=4.5e-22 conditioned to 0.000822

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex PPA2 0.08 0.03 bslmm 429 0.04 2.2e-05 -6.1 -6.7 2.0e-11 0.66 0.04 0.95 FALSE
2 GTEx Artery Aorta PPA2 0.11 -0.01 enet 24 0.01 1.6e-01 -9.5 -6.5 6.5e-11 0.63 0.04 0.63 FALSE
3 GTEx Brain Cerebellum PPA2 0.22 0.01 lasso 4 0.03 3.7e-02 -6.7 -5.3 9.0e-08 0.62 0.09 0.16 FALSE
4 GTEx Brain Cortex PPA2 0.14 0.09 lasso 9 0.09 1.6e-03 -8.0 -8.1 5.4e-16 0.88 0.04 0.69 FALSE
5 GTEx Cells Transformed fibroblasts PPA2 0.11 0.03 lasso 3 0.01 6.5e-02 -6.6 -6.9 4.4e-12 0.67 0.36 0.22 FALSE
6 GTEx Esophagus Gastroesophageal Junction PPA2 0.29 0.15 lasso 5 0.14 8.8e-06 -9.5 -9.2 4.3e-20 0.88 0.02 0.97 TRUE
7 GTEx Esophagus Mucosa PPA2 0.18 0.06 enet 14 0.12 2.5e-08 6.0 -7.5 6.9e-14 0.72 0.02 0.97 FALSE
8 GTEx Heart Atrial Appendage PPA2 0.15 0.05 lasso 7 0.06 7.4e-04 -7.9 -6.1 8.9e-10 0.71 0.21 0.44 FALSE
9 GTEx Muscle Skeletal PPA2 0.19 0.06 enet 28 0.11 8.7e-11 -7.8 -5.2 2.6e-07 0.60 0.72 0.28 FALSE
10 GTEx Nerve Tibial PPA2 0.13 0.07 enet 23 0.07 2.1e-05 -6.7 -6.3 3.8e-10 0.66 0.35 0.47 FALSE
11 GTEx Ovary PPA2 0.18 0.10 lasso 3 0.14 2.2e-04 -6.7 -7.5 8.5e-14 0.76 0.04 0.77 FALSE
12 GTEx Skin Sun Exposed Lower leg TET2 0.09 0.01 enet 18 0.02 3.6e-03 -9.6 -6.5 6.9e-11 0.69 0.01 0.93 FALSE
13 The Cancer Genome Atlas Thyroid Carcinoma PPA2 0.04 0.02 blup 84 0.04 6.1e-05 -7.8 -7.1 1.2e-12 0.77 0.14 0.65 FALSE