Best TWAS P=9.41e-09 · Best GWAS P=5.58e-09 conditioned to 0.00209
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Cells Transformed fibroblasts | SUPT3H | 0.15 | 0.10 | lasso | 4 | 0.13 | 8.8e-10 | 5.2 | -5.7 | 1.5e-08 | -0.55 | 0.05 | 0.95 | FALSE |
2 | GTEx | Esophagus Mucosa | SUPT3H | 0.08 | 0.09 | lasso | 3 | 0.08 | 6.4e-06 | 5.4 | -5.2 | 1.6e-07 | -0.46 | 0.03 | 0.96 | FALSE |
3 | GTEx | Nerve Tibial | SUPT3H | 0.17 | 0.12 | lasso | 5 | 0.10 | 2.2e-07 | 5.4 | -5.4 | 5.6e-08 | -0.51 | 0.05 | 0.95 | FALSE |
4 | GTEx | Pancreas | SUPT3H | 0.11 | 0.07 | lasso | 2 | 0.05 | 3.6e-03 | 5.7 | -5.7 | 1.4e-08 | -0.52 | 0.05 | 0.88 | FALSE |
5 | NTR | Blood | SUPT3H | 0.03 | 0.02 | lasso | 7 | 0.02 | 1.9e-07 | -5.1 | -5.2 | 1.7e-07 | -0.65 | 0.12 | 0.88 | FALSE |
6 | YFS | Blood | SUPT3H | 0.06 | 0.09 | lasso | 13 | 0.12 | 2.2e-36 | 5.4 | -5.7 | 9.4e-09 | -0.58 | 0.07 | 0.93 | TRUE |
7 | The Cancer Genome Atlas | Breast Invasive Carcinoma | SUPT3H | 0.02 | 0.01 | blup | 191 | 0.01 | 3.0e-03 | 5.4 | -5.7 | 1.5e-08 | -0.45 | 0.03 | 0.96 | FALSE |
8 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | SUPT3H | 0.04 | 0.01 | blup | 191 | 0.02 | 6.5e-03 | -4.9 | -5.7 | 1.4e-08 | -0.47 | 0.05 | 0.92 | FALSE |
9 | The Cancer Genome Atlas | Brain Lower Grade Glioma | SUPT3H | 0.07 | 0.05 | enet | 12 | 0.08 | 1.1e-09 | -4.6 | -5.7 | 1.1e-08 | -0.59 | 0.11 | 0.88 | FALSE |
10 | The Cancer Genome Atlas | Lung Adenocarcinoma | SUPT3H | 0.03 | 0.03 | lasso | 2 | 0.02 | 8.9e-04 | 5.3 | -5.7 | 1.3e-08 | -0.55 | 0.05 | 0.85 | FALSE |
11 | The Cancer Genome Atlas | Stomach Adenocarcinoma | SUPT3H | 0.05 | 0.01 | blup | 191 | 0.00 | 1.4e-01 | -4.2 | -5.5 | 3.5e-08 | -0.53 | 0.08 | 0.38 | FALSE |