[Hub]/) : Traits : Leg predicted mass (right) : ← →

chr6:41,005,502-42,715,323

Best TWAS P=4.27e-29 · Best GWAS P=3.42e-28 conditioned to 8.3e-06

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	MED20	0.15	0.11	blup	471	0.13	3.1e-15	-7.997	7.4	1.6e-13	0.61	1.00	0.00	FALSE
2	GTEx	Adipose Subcutaneous	MED20	0.08	0.07	enet	9	0.05	4.7e-05	8.595	8.6	9.7e-18	0.61	0.96	0.01	FALSE
3	GTEx	Adipose Subcutaneous	FRS3	0.15	0.04	enet	22	0.04	5.9e-04	9.221	7.3	3.7e-13	0.57	0.20	0.56	FALSE
4	GTEx	Artery Tibial	MED20	0.14	0.11	lasso	2	0.09	9.7e-08	8.719	8.7	2.9e-18	0.60	0.99	0.01	FALSE
5	GTEx	Cells EBV-transformed lymphocytes	MED20	0.25	0.01	lasso	5	0.07	3.0e-03	-7.869	6.8	9.8e-12	0.53	0.15	0.12	FALSE
6	GTEx	Cells Transformed fibroblasts	MED20	0.11	0.05	lasso	4	0.08	9.4e-07	-9.768	10.2	2.2e-24	0.46	0.86	0.09	FALSE
7	GTEx	Cells Transformed fibroblasts	USP49	0.13	0.02	lasso	4	0.02	2.4e-02	-9.345	-8.6	6.0e-18	-0.37	0.29	0.03	FALSE
8	GTEx	Colon Transverse	MED20	0.17	0.01	enet	10	0.06	6.0e-04	8.697	10.0	2.5e-23	0.69	0.17	0.62	FALSE
9	GTEx	Esophagus Mucosa	MED20	0.09	0.07	enet	10	0.02	2.7e-02	-7.997	8.3	8.2e-17	0.59	0.76	0.13	FALSE
10	GTEx	Esophagus Muscularis	MED20	0.15	0.05	lasso	7	0.04	1.0e-03	-8.012	8.4	3.6e-17	0.62	0.45	0.50	FALSE
11	GTEx	Heart Atrial Appendage	MED20	0.14	0.12	enet	11	0.09	5.9e-05	8.383	8.2	2.5e-16	0.58	0.84	0.09	FALSE
12	GTEx	Heart Left Ventricle	PRICKLE4	0.11	0.05	lasso	4	0.03	9.8e-03	7.736	-8.0	9.9e-16	-0.59	0.26	0.06	FALSE
13	GTEx	Heart Left Ventricle	MED20	0.22	0.19	enet	8	0.12	5.8e-07	8.697	8.9	8.3e-19	0.61	1.00	0.00	FALSE
14	GTEx	Liver	MED20	0.20	0.03	enet	54	0.08	3.4e-03	8.621	5.3	9.2e-08	0.39	0.17	0.19	FALSE
15	GTEx	Lung	BYSL	0.08	0.03	lasso	4	0.02	4.9e-03	9.511	-9.6	9.2e-22	-0.80	0.27	0.56	FALSE
16	GTEx	Lung	PRICKLE4	0.12	0.05	lasso	3	0.06	2.2e-05	7.736	-5.7	1.6e-08	-0.54	0.60	0.07	FALSE
17	GTEx	Lung	MED20	0.10	0.01	lasso	4	0.00	2.7e-01	-1.213	7.0	2.5e-12	0.52	0.06	0.32	FALSE
18	GTEx	Lung	USP49	0.09	0.08	lasso	2	0.05	6.2e-05	-9.345	-8.8	1.7e-18	-0.33	0.84	0.01	FALSE
19	GTEx	Muscle Skeletal	MED20	0.16	0.15	lasso	4	0.16	6.7e-16	7.736	8.0	9.4e-16	0.60	1.00	0.00	FALSE
20	GTEx	Nerve Tibial	MED20	0.13	0.11	enet	8	0.10	1.5e-07	8.383	8.4	4.4e-17	0.58	1.00	0.00	FALSE
21	GTEx	Spleen	MED20	0.44	0.13	enet	23	0.07	6.4e-03	8.719	7.2	4.8e-13	0.57	0.11	0.51	FALSE
22	GTEx	Testis	MED20	0.13	0.03	lasso	6	0.00	2.0e-01	-9.323	9.6	6.7e-22	0.46	0.16	0.17	FALSE
23	GTEx	Thyroid	MED20	0.05	0.05	lasso	2	0.02	8.1e-03	8.768	8.9	3.7e-19	0.61	0.50	0.36	FALSE
24	GTEx	Thyroid	FRS3	0.20	0.16	lasso	4	0.16	5.2e-12	9.221	8.6	9.6e-18	0.67	0.98	0.02	FALSE
25	METSIM	Adipose	BYSL	0.05	0.00	blup	476	0.02	2.3e-04	7.736	-5.6	2.8e-08	-0.46	0.18	0.06	FALSE
26	METSIM	Adipose	MED20	0.13	0.11	enet	27	0.11	2.3e-16	8.548	9.0	1.5e-19	0.61	1.00	0.00	FALSE
27	ROSMAP	Brain Pre-frontal Cortex	PGC	0.13	0.06	blup	520	0.06	3.2e-08	9.221	-8.1	7.9e-16	-0.58	0.97	0.03	FALSE
28	ROSMAP	Brain Pre-frontal Cortex	MED20	0.10	0.10	enet	21	0.09	6.0e-12	8.768	8.5	1.6e-17	0.61	1.00	0.00	FALSE
29	YFS	Blood	BYSL	0.07	0.06	lasso	7	0.09	2.8e-28	8.719	-5.5	3.8e-08	-0.55	1.00	0.00	FALSE
30	YFS	Blood	CCND3	0.02	0.01	enet	13	0.02	2.3e-06	8.170	-8.6	5.6e-18	-0.55	0.72	0.22	FALSE
31	YFS	Blood	MED20	0.04	0.03	lasso	5	0.03	3.6e-11	7.736	7.2	7.0e-13	0.61	1.00	0.00	FALSE
32	The Cancer Genome Atlas	Breast Invasive Carcinoma	CCND3	0.04	0.00	blup	99	0.01	1.8e-03	-9.282	8.5	1.6e-17	0.45	0.02	0.10	FALSE
33	The Cancer Genome Atlas	Colon Adenocarcinoma	MED20	0.05	0.00	blup	50	0.04	2.8e-03	7.736	11.2	4.3e-29	0.70	0.06	0.27	TRUE
34	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	MED20	0.04	0.03	lasso	3	0.04	7.3e-05	-9.768	9.9	3.7e-23	0.45	0.57	0.02	FALSE
35	The Cancer Genome Atlas	Brain Lower Grade Glioma	MED20	0.09	0.08	enet	12	0.09	5.5e-10	8.719	9.7	2.2e-22	0.62	1.00	0.00	FALSE
36	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	MED20	0.09	0.07	lasso	5	0.07	3.4e-04	-9.323	10.4	2.4e-25	0.51	0.17	0.55	FALSE
37	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	PRICKLE4	0.03	0.01	blup	43	0.02	1.6e-03	0.018	-5.9	3.8e-09	-0.58	0.19	0.54	FALSE
38	The Cancer Genome Atlas	Prostate Adenocarcinoma	MED20	0.04	0.06	enet	6	0.05	2.6e-06	7.736	9.1	1.3e-19	0.58	0.91	0.02	FALSE
39	The Cancer Genome Atlas	Stomach Adenocarcinoma	MED20	0.03	0.05	lasso	2	0.04	1.2e-03	-9.768	10.0	2.2e-23	0.44	0.11	0.06	FALSE
40	The Cancer Genome Atlas	Thyroid Carcinoma	BYSL	0.05	0.06	enet	7	0.06	4.3e-06	8.768	-8.5	1.9e-17	-0.56	0.82	0.09	FALSE
41	The Cancer Genome Atlas	Thyroid Carcinoma	PRICKLE4	0.04	0.03	lasso	3	0.04	1.1e-04	6.484	-6.2	5.2e-10	-0.60	0.34	0.27	FALSE