Best TWAS P=2.47e-16 · Best GWAS P=8.59e-14 conditioned to 0.307
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Visceral Omentum | RP11-250B2.6 | 0.16 | 0.05 | lasso | 6 | 0.06 | 7.8e-04 | 5.9 | -6.6 | 4.5e-11 | -0.57 | 0.18 | 0.53 | FALSE |
| 2 | GTEx | Brain Cerebellum | RP11-250B2.5 | 0.43 | 0.11 | lasso | 5 | 0.14 | 4.7e-05 | -6.8 | -6.1 | 1.1e-09 | -0.76 | 0.08 | 0.82 | FALSE |
| 3 | GTEx | Cells Transformed fibroblasts | BCKDHB | 0.16 | 0.02 | enet | 42 | 0.04 | 3.7e-04 | 4.5 | 7.7 | 1.9e-14 | 0.49 | 0.25 | 0.63 | FALSE |
| 4 | GTEx | Esophagus Mucosa | RP11-250B2.6 | 0.20 | 0.16 | lasso | 7 | 0.23 | 3.3e-15 | -6.6 | -6.6 | 4.7e-11 | -0.65 | 0.65 | 0.35 | FALSE |
| 5 | GTEx | Heart Atrial Appendage | RP11-250B2.6 | 0.20 | 0.00 | enet | 17 | 0.03 | 2.6e-02 | -3.6 | -8.2 | 2.5e-16 | -0.41 | 0.05 | 0.52 | TRUE |
| 6 | GTEx | Heart Left Ventricle | RP11-250B2.6 | 0.09 | 0.00 | enet | 6 | 0.02 | 2.0e-02 | 6.6 | -6.3 | 3.7e-10 | -0.82 | 0.04 | 0.77 | FALSE |
| 7 | GTEx | Lung | RP11-250B2.6 | 0.09 | 0.05 | enet | 16 | 0.07 | 5.3e-06 | 4.5 | -6.3 | 3.0e-10 | -0.36 | 0.82 | 0.03 | FALSE |
| 8 | GTEx | Muscle Skeletal | RP11-250B2.6 | 0.07 | 0.04 | lasso | 5 | 0.04 | 4.2e-05 | 7.3 | -7.5 | 8.8e-14 | -0.94 | 0.01 | 0.99 | TRUE |
| 9 | GTEx | Testis | RP11-250B2.5 | 0.13 | 0.17 | lasso | 3 | 0.14 | 7.0e-07 | -6.6 | -6.5 | 8.5e-11 | -0.88 | 0.04 | 0.95 | FALSE |
| 10 | GTEx | Thyroid | BCKDHB | 0.17 | 0.06 | lasso | 8 | 0.10 | 3.4e-08 | 4.5 | 6.1 | 1.2e-09 | 0.46 | 0.97 | 0.03 | FALSE |
| 11 | METSIM | Adipose | RP11-250B2.6 | 0.04 | 0.04 | lasso | 12 | 0.02 | 1.7e-04 | 6.3 | -5.7 | 1.3e-08 | -0.60 | 0.64 | 0.14 | FALSE |
| 12 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | BCKDHB | 0.12 | 0.06 | lasso | 4 | 0.06 | 4.2e-07 | 5.6 | -5.2 | 1.7e-07 | -0.75 | 0.44 | 0.55 | FALSE |