[Hub]/) : Traits : Leg predicted mass (right) :

chr6:124,741,508-127,355,237

Best TWAS P=7.46e-27 · Best GWAS P=2.53e-28 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex CENPW 0.04 0.06 lasso 10 0.06 2.4e-07 10.74 -10.7 7.5e-27 -0.99 0.02 0.98 TRUE
2 CommonMind Brain Pre-frontal Cortex HEY2 0.15 0.20 lasso 10 0.21 6.7e-25 -8.81 -8.7 2.7e-18 -0.07 0.01 0.99 FALSE
3 GTEx Artery Coronary TPD52L1 0.31 -0.01 enet 19 0.05 7.0e-03 0.41 -6.2 4.7e-10 -0.15 0.03 0.54 FALSE
4 GTEx Esophagus Muscularis HINT3 0.08 0.00 enet 14 0.00 2.9e-01 8.46 -7.2 8.0e-13 -0.11 0.07 0.04 FALSE
5 GTEx Pancreas HEY2 0.28 0.11 lasso 3 0.10 3.5e-05 -6.29 -7.1 1.5e-12 -0.05 0.10 0.90 FALSE
6 GTEx Skin Sun Exposed Lower leg HINT3 0.08 0.01 lasso 4 0.03 2.0e-03 -3.39 -5.2 2.5e-07 -0.19 0.22 0.13 FALSE
7 GTEx Testis HEY2 0.31 0.17 lasso 5 0.19 7.4e-09 -8.74 -8.8 1.7e-18 -0.08 0.01 0.99 FALSE
8 GTEx Thyroid HEY2 0.22 0.24 lasso 6 0.23 1.0e-17 -8.74 -8.9 7.4e-19 -0.08 0.01 0.99 TRUE
9 GTEx Vagina CENPW 0.24 -0.01 lasso 8 -0.01 7.9e-01 5.19 5.9 4.7e-09 0.41 0.04 0.07 FALSE
10 METSIM Adipose CENPW 0.02 0.02 blup 189 0.01 8.3e-03 10.93 -7.6 2.1e-14 -0.74 0.02 0.79 FALSE
11 METSIM Adipose HEY2 0.02 0.04 lasso 1 0.02 1.6e-04 -6.42 -6.4 1.4e-10 -0.05 0.02 0.97 FALSE
12 METSIM Adipose NCOA7 0.05 0.05 enet 5 0.05 1.9e-07 6.85 8.5 1.7e-17 0.24 0.95 0.02 FALSE
13 ROSMAP Brain Pre-frontal Cortex HEY2 0.10 0.12 enet 15 0.13 9.8e-17 8.29 -8.0 9.7e-16 -0.06 0.01 0.99 FALSE
14 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma CENPW 0.04 0.05 lasso 5 0.05 2.6e-06 11.01 -10.5 9.3e-26 -0.98 0.01 0.98 FALSE
15 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma HEY2 0.05 0.05 blup 36 0.05 4.9e-06 -6.29 -5.3 1.2e-07 -0.03 0.17 0.82 FALSE
16 The Cancer Genome Atlas Brain Lower Grade Glioma CENPW 0.04 0.06 blup 35 0.05 9.2e-07 10.78 -10.6 1.9e-26 -0.98 0.01 0.99 FALSE
17 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma HEY2 0.09 0.06 lasso 8 0.06 2.3e-03 -6.29 -6.2 5.2e-10 -0.03 0.03 0.76 FALSE
18 The Cancer Genome Atlas Thyroid Carcinoma HEY2 0.03 0.04 lasso 3 0.02 3.8e-03 7.83 -8.1 7.3e-16 -0.07 0.01 0.98 FALSE