Hub : Genes

NCOA7

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adrenal Gland	0.1941	0.0780	6.6e-03	0.125	NA	0.013	NA	0.099	3.2e-05	NA	1.0e-01	NA	2.1e-04
2	GTEx	Testis	0.1820	0.0720	4.1e-03	0.029	NA	0.091	NA	0.078	1.9e-02	NA	7.5e-05	NA	2.4e-04
3	METSIM	Adipose	0.0550	0.0209	4.2e-04	0.049	0.029	0.046	0.034	0.045	7.6e-08	2.9e-05	1.9e-07	6.3e-06	2.6e-07
4	YFS	Blood	0.0485	0.0122	2.2e-13	0.051	0.044	0.049	0.048	0.048	2.4e-16	3.0e-14	9.3e-16	2.5e-15	1.8e-15
5	TCGA	Kidney Renal Papillary Cell Carcinoma	0.0730	0.0350	7.1e-04	0.024	0.035	0.036	NA	0.041	1.5e-02	4.2e-03	4.0e-03	NA	2.1e-03
6	TCGA	Skin Cutaneous Melanoma	0.3300	0.1110	6.1e-04	0.052	0.202	0.125	NA	0.066	1.7e-02	4.2e-06	3.2e-04	NA	7.7e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	1.0	1.6	5.2	-1.0	0.1	0.6	-1.2	2.3	-1.1
Bipolar Disorder or Schizophrenia	0.2	0.5	1.1	-0.9	-0.1	1.0	-0.3	1.1	0.1
Depressed Affect (Nagel 2018)	0.5	1.0	5.2	0.5	-0.3	-2.3	0.5	0.6	-0.4
Depression (Nagel 2018)	0.1	0.2	0.5	0.6	-0.7	-0.3	-0.5	0.0	0.3
Intelligence (Savage-Jansen 2018)	0.7	2.2	5.0	-2.2	1.3	2.1	-1.0	0.8	-0.6
Neuroticism (Nagel 2018)	0.3	0.7	3.6	-0.2	0.2	-1.9	0.1	0.5	-0.0
Schizophrenia (2018)	0.2	0.4	1.1	-0.3	-0.3	0.8	0.7	-0.5	1.1
Schizophrenia vs Biploar Disorder	0.4	0.5	1.4	0.0	0.2	0.0	1.2	-0.6	1.2
Worry (Nagel 2018)	0.2	0.3	0.6	-0.3	0.8	-0.4	-0.7	0.6	-0.4
Alzheimer’s Disease (in mother)	0.8	0.9	2.7	0.2	0.3	1.3	-0.9	0.4	1.6
Alzheimer’s Disease (in father)	0.1	0.1	0.3	0.4	0.2	0.3	-0.3	-0.6	0.3
Alzheimer’s Disease (including proxy)	0.8	1.1	3.3	0.2	0.1	1.3	-1.8	0.7	1.0
Crohns Disease (2017)	0.7	1.5	2.8	1.7	0.2	-0.4	-1.6	1.6	1.0
Irritable Bowel Disease (IBD)	0.3	0.6	1.7	0.1	0.8	-1.1	0.0	-0.3	1.3
Ulcerative Colitis (UC)	1.0	1.8	3.6	-1.3	1.2	-1.0	1.5	-1.9	0.9
Major Depression (MDD)	1.3	1.6	3.0	1.6	-1.2	-1.1	-0.9	0.7	1.7
Reaction Time	1.5	2.9	6.3	0.9	-0.9	2.5	-2.2	1.8	1.1
Verbal and Numeric Reasoning (VNR)	1.5	3.6	6.1	-1.2	1.3	2.5	-2.4	1.6	-2.0
Breast Cancer	0.2	0.6	1.9	0.7	-1.4	-0.7	0.1	-0.2	0.7
Ovarian Cancer	1.5	2.0	5.3	0.1	-0.8	-1.6	2.3	-1.6	0.6
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.9	1.3	3.4	-1.1	-0.1	1.8	-1.2	0.9	-0.8
Bipolar Disorder (2011)	0.7	0.7	1.2	-0.9	0.4	0.9	-0.8	1.1	-0.8
Body Mass Index (BMI) (2010)	0.8	1.1	1.4	1.1	1.1	1.2	-1.0	0.9	1.0
Coronary Artery Disease (CAD)	0.5	0.6	2.9	-0.2	-0.6	-1.7	0.1	-0.7	-0.2
Crohns Disease (2012)	0.6	0.9	1.8	1.3	0.2	0.5	-1.0	1.4	0.6
Mean Putamen Volume	0.7	0.8	2.2	0.6	0.2	-0.0	-1.5	1.5	-0.0
Fasting Glucose	0.3	0.4	1.3	1.1	-0.6	0.1	-0.6	0.5	0.3
HbA1C	2.5	2.8	9.0	-1.6	1.5	3.0	-1.6	-0.2	0.5
HDL Cholesterol	2.0	3.3	8.4	0.3	-0.4	-2.6	1.6	-2.9	1.4
LDL Cholesterol	1.7	2.6	6.8	2.6	-0.8	1.0	-1.6	1.4	1.6
Lupus	1.4	2.1	7.3	-1.6	1.3	2.7	0.9	0.1	0.2
Neuroticism (2016)	0.7	1.0	2.3	0.4	-1.4	-1.5	0.7	0.3	0.8
Primary Biliary Cirrhosis	1.5	2.2	3.8	1.6	-0.5	1.1	-1.9	1.2	1.9
Rheumatoid Arthritis	0.4	0.6	1.9	0.8	-0.7	-1.4	-0.0	-0.4	0.3
Schizophrenia (2014)	0.5	1.1	2.2	-1.5	1.3	1.4	0.7	-0.0	0.7
Triglycerides	1.7	2.9	7.7	2.0	-0.7	1.6	-1.5	2.8	-0.4
Type 2 Diabetes (T2D) (2012)	0.5	0.6	1.2	-0.5	-0.4	0.8	-1.1	0.8	0.7
Ulcerative Colitis	0.1	0.2	0.5	-0.7	0.3	-0.5	0.4	-0.4	-0.2
Blood Eosinophil Count	0.2	1.2	3.3	0.2	-0.7	1.8	-0.0	1.1	1.6
Blood Platelet Count	0.7	7.8	17.0	1.0	-3.6	-3.0	2.6	-4.1	0.5
Blood Red Count	2.9	27.6	93.5	-4.7	9.7	2.8	-3.8	4.8	-2.4
Blood White Count	0.3	1.9	4.5	-0.0	0.4	-2.1	1.7	-1.5	1.3
Heel T-Score	1.0	7.6	21.9	3.5	-2.0	0.3	0.0	4.7	2.8
BMI	1.2	6.8	16.6	-1.2	2.2	3.5	-2.0	1.4	4.1
Height	2.5	47.3	193.2	-4.7	6.4	13.9	-3.0	4.3	0.5
Waist Hip Ratio (WHR)	1.2	5.4	24.9	-0.2	-0.3	0.8	-1.1	5.0	-2.4
Systolic Blood Pressure	1.5	7.7	14.6	-2.1	1.8	3.0	-3.2	3.8	-2.1
Smoking Status	0.2	0.5	1.2	-0.5	-1.1	-0.4	0.0	0.8	-0.9
Allergy or Eczema	1.0	2.6	6.5	2.2	-2.5	-1.9	0.1	-0.6	0.3
Cardiovascular Disease	1.2	4.0	10.1	-0.7	0.3	3.1	-1.5	3.2	1.2
Hypothyroidism (self reported)	0.5	1.2	3.2	1.1	-1.5	0.8	-0.3	0.0	1.8
Respiratory disease	1.8	4.0	11.4	2.8	-3.4	-1.8	-1.1	0.1	-0.2
Type 2 Diabetes (T2D) (2018)	0.6	1.1	3.2	0.1	0.3	1.6	-0.4	1.8	0.9
Lung FEV1/FVC ratio	1.5	7.5	19.5	-3.4	4.4	2.2	-1.3	2.2	-1.6
Lung FVC	0.3	1.7	2.7	0.5	1.2	1.6	1.4	-1.6	1.1
Neuroticism	0.4	1.0	3.9	0.5	-0.8	-2.0	-0.5	0.8	0.1
Chronotype (morning person)	0.9	2.0	9.9	0.7	-0.1	0.3	1.2	0.6	3.1
Hair Pigment	0.1	3.3	9.2	-0.3	-1.7	-3.0	1.9	-1.7	0.9
Tanning	0.0	0.3	1.1	-0.3	0.1	0.4	0.1	1.1	-0.6
Hand grip strength (left)	2.5	6.5	18.6	-2.2	4.3	3.8	-0.5	0.8	-0.2
Number of treatments/medications taken	0.9	1.6	3.6	0.3	-0.5	0.9	-1.6	1.5	1.9
Average weekly spirits intake	0.7	0.9	2.5	-0.9	1.1	1.6	-0.5	0.7	-0.0
Sensitivity / hurt feelings	1.5	2.5	5.5	1.3	-1.8	-2.4	0.1	-0.3	2.1
Frequency of depressed mood in last 2 weeks	0.7	1.0	2.4	1.5	-1.4	-0.8	-0.7	0.5	0.9
Hearing difficulty/problems: Yes	0.3	0.4	1.2	-0.2	0.2	0.1	0.9	-0.6	1.1
Relative age of first facial hair	0.3	0.6	1.4	-1.2	0.1	0.2	0.2	-0.8	-1.2
Other serious medical condition/disability diagnosed by doctor	0.8	1.0	2.5	1.0	-0.2	-0.8	0.7	-1.1	1.6
Ever used hormone-replacement therapy (HRT)	1.4	1.8	6.2	2.5	-1.7	-0.4	-0.4	0.9	0.6
Ever had hysterectomy (womb removed)	1.7	2.0	4.8	1.0	-0.8	0.4	-0.8	2.2	2.2
Systolic blood pressure, automated reading	1.3	3.6	7.5	-1.2	1.6	1.7	-2.6	2.7	-0.6
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	1.1	0.6	-1.0	0.0	-1.0	0.8	-0.1
Angina	0.3	0.3	0.7	0.6	0.8	-0.4	0.3	0.6	-0.6
Medication for hormone replacement therapy	1.3	1.5	4.1	2.0	-0.7	0.6	-1.1	1.6	-0.4
Vitamin and mineral supplements	0.6	0.8	2.9	-1.2	0.6	0.1	0.3	-0.4	-1.7
Supplements: Zinc	0.5	0.6	0.7	-0.7	0.7	0.8	-0.8	0.8	0.5
Medication: Co-codamol	0.2	0.2	0.3	0.6	-0.5	0.6	-0.3	0.5	-0.3
Medication: Metformin	0.4	0.6	1.3	-0.8	0.9	0.2	0.5	0.7	1.1
Diabetes (father)	1.6	2.0	5.7	0.4	0.6	1.1	-2.4	2.1	-0.2
Diabetes (mother)	0.9	1.2	2.8	0.5	-0.4	1.7	-0.9	1.6	0.5
Severe depression (siblings)	0.5	0.5	1.7	0.8	0.1	-0.7	-0.2	-0.5	1.3
Pack years adult smoking proportion	1.2	1.8	4.8	0.3	-0.1	1.6	-1.6	2.2	-0.9
Impedance of leg (right)	2.5	12.3	32.3	0.8	-2.5	-5.7	3.6	-4.0	-2.5
Leg fat-free mass (left)	3.7	19.8	65.9	-1.9	3.9	8.1	-3.0	3.5	3.7
Trunk fat percentage	0.6	2.4	9.2	-0.9	1.6	0.4	-0.5	-1.1	3.0
Hand grip strength (right)	3.3	9.1	22.2	-3.7	4.7	4.2	0.4	0.7	-0.3
Townsend deprivation index at recruitment	0.7	1.0	2.1	0.7	-0.2	1.0	-1.1	0.9	1.4
Current tobacco smoking	0.5	0.9	2.4	0.7	-1.2	-0.4	0.4	0.9	-1.5
Average weekly fortified wine intake	1.2	1.4	4.8	0.9	0.3	1.2	-2.2	0.7	1.1
Maternal smoking around birth	0.8	1.2	4.7	1.1	-0.3	-2.2	1.1	-0.3	-0.2
Fed-up feelings	0.7	1.4	3.3	0.8	-0.8	-1.8	1.2	0.1	1.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	2.9	0.3	0.1	-0.3	1.0	-0.7	1.7
Relative age voice broke	0.7	1.0	2.1	-1.0	-0.3	-0.9	1.0	-1.4	-1.2
Taking other prescription medications	2.1	3.3	9.0	3.0	-1.4	0.4	-1.2	1.2	2.4
Age when periods started (menarche)	0.9	2.2	7.4	-1.8	2.7	-0.1	1.1	-0.9	-1.0
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	2.1	0.3	1.4	1.4	-0.8	0.8	-0.4
Heel bone mineral density (BMD) T-score, automated (left)	1.9	4.2	7.3	2.5	-0.3	1.9	-0.8	2.7	2.6
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.2	-0.4	-0.1	-0.1	-0.2	-0.1	-0.3
Qualifications: CSEs or equivalent	0.5	0.6	1.2	1.1	-0.0	-1.1	0.9	0.1	-0.7
Serious illness, injury or assault to yourself	0.2	0.2	0.7	0.2	-0.4	-0.8	0.1	-0.3	0.3
High blood pressure	1.2	3.2	6.9	-0.8	0.3	2.6	-1.2	2.5	2.0
Hayfever, allergic rhinitis or eczema	1.0	2.2	6.6	1.7	-2.6	-1.6	0.3	-0.4	0.7
Multivitamins +/- minerals	0.3	0.4	1.5	0.5	-0.4	-0.4	0.1	0.1	1.2
Stomach or abdominal pain in last month	0.3	0.3	0.9	-0.3	0.2	0.5	0.3	0.9	-0.8
Supplements: Glucosamine	1.0	1.3	4.1	1.2	-2.0	-1.0	-0.7	0.9	0.2
Diverticular disease/diverticulitis (self-reported)	0.7	0.9	2.8	-1.7	-0.1	-0.0	0.3	-0.2	-1.6
Medication: Atenolol	0.5	0.6	2.3	-1.5	-0.4	0.1	0.1	0.9	0.1
Medication: Levothyroxine sodium	0.4	0.6	2.2	1.0	-0.7	-0.2	-0.2	-0.1	1.5
Sitting height	2.6	18.8	75.9	-3.8	3.8	8.7	-0.6	2.4	1.3
Chronic bronchitis/emphysema (father)	0.6	0.7	1.3	1.0	-1.1	-1.0	-0.3	0.7	0.3
High blood pressure (mother)	1.5	2.2	4.1	1.6	-0.3	1.9	-1.4	2.0	0.9
Body mass index (BMI)	1.0	4.1	12.5	-0.9	1.9	2.2	-1.4	0.7	3.5
Impedance of leg (left)	2.3	11.4	28.4	0.2	-1.9	-5.3	3.6	-4.2	-2.4
Leg predicted mass (left)	3.7	19.7	65.9	-2.0	3.7	8.1	-2.9	3.5	3.7
Trunk fat mass	1.3	5.4	14.2	-1.3	2.5	3.0	-1.3	0.1	3.8
Waist circumference	1.6	5.8	13.2	-1.8	2.3	3.6	-1.8	1.8	2.5
Number of incorrect matches in round	1.0	1.7	4.4	1.6	-0.5	-0.8	-0.8	1.2	2.1
Past tobacco smoking	0.1	0.3	1.0	0.3	0.5	0.2	-0.5	1.0	0.0
Alcohol usually taken with meals	1.0	1.6	5.3	1.0	-2.3	-0.2	-1.7	0.8	0.1
Nervous feelings	0.1	0.3	0.7	0.2	0.1	-0.5	-0.6	0.5	-0.8
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.9	-0.1	-0.2	-0.2	0.9	-0.1	0.2
Hearing difficulty/problems with background noise	0.7	1.2	2.6	1.6	-1.6	-1.1	-0.5	-0.2	0.6
Hair/balding pattern: Pattern 2	3.0	3.9	10.9	-0.0	1.0	3.3	-2.1	2.6	0.3
Had menopause	0.4	0.5	1.2	0.2	-0.7	0.4	-0.2	1.1	1.1
Had other major operations	0.4	0.5	1.6	1.3	-0.0	-0.4	-0.6	-0.1	0.8
Forced vital capacity (FVC)	1.0	3.9	19.0	0.0	1.6	4.4	0.2	0.6	1.1
Heel bone mineral density (BMD) T-score, automated (right)	1.3	2.9	5.6	2.0	-0.6	1.4	-0.5	2.4	2.2
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	4.4	0.8	-2.1	-0.9	0.4	-0.4	0.6
Qualifications: None of the above	0.5	1.0	2.6	0.2	0.4	-1.3	1.0	-1.6	0.8
Financial difficulties in last 2 years	0.5	0.7	1.6	-0.2	-1.2	-1.0	-0.3	1.2	-0.5
Mouth/teeth dental problems	1.7	2.6	8.1	2.3	-1.3	-0.2	-0.1	0.1	2.8
Heart attack	0.9	1.2	2.2	-1.0	0.6	-0.7	1.5	-1.3	-1.2
Allergy	1.8	4.2	11.4	-3.4	3.0	1.6	0.8	-0.7	-0.9
Pain all over the body in last month	0.5	0.6	1.1	1.0	-0.9	-0.3	-0.1	-0.5	1.1
Diabetes (self-reported)	0.4	0.6	1.9	-0.4	0.6	0.7	0.6	0.5	1.4
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	1.4	-0.2	-1.2	-0.9	0.4	-0.6	-0.1
Medication: Ramipril	1.7	2.2	4.3	-1.3	2.1	1.9	-1.3	1.5	-0.0
Medication: Simvastatin	1.2	1.7	4.9	-0.1	0.1	1.1	-2.2	2.1	0.1
Fluid intelligence score	1.4	2.8	4.6	-0.8	0.4	2.0	-2.0	1.9	-2.1
Illnesses of siblings	1.2	1.7	5.0	-0.2	-0.8	-1.7	0.8	-2.2	-1.0
Neuroticism score	0.4	0.9	2.5	0.5	-0.5	-1.6	-0.6	1.3	0.5
Weight	2.6	12.8	37.3	-1.7	3.0	6.1	-2.3	2.0	4.3
Impedance of arm (right)	1.7	8.1	27.0	0.6	-2.3	-5.2	1.6	-2.7	-2.4
Arm fat percentage (right)	0.5	1.8	9.5	-0.3	0.7	-0.4	-0.6	-0.4	3.1
Trunk fat-free mass	4.0	23.1	87.2	-2.0	3.3	9.3	-2.9	4.1	3.4
Hip circumference	1.8	7.6	19.7	-1.5	2.5	4.4	-2.6	0.3	3.2
Time employed in main current job	1.2	1.4	3.7	0.5	0.6	1.9	-1.2	1.1	1.2
Alcohol intake versus 10 years previously	1.1	1.7	4.0	0.0	-0.5	2.0	-2.0	1.2	0.7
Father’s age at death	0.7	1.0	3.5	0.3	-0.6	0.2	-1.4	0.0	-1.9
Worrier / anxious feelings	0.5	1.0	3.7	0.6	0.5	-0.1	-1.3	1.9	0.4
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	2.8	0.5	0.4	-0.5	0.7	-0.8	1.7
Falls in the last year	0.3	0.4	1.3	-0.1	0.6	-0.2	-0.2	0.8	1.1
Hair/balding pattern: Pattern 3	1.5	2.2	8.2	1.1	-0.8	-2.9	-0.4	-1.1	-1.4
Number of live births	1.0	1.5	4.0	-0.3	-0.9	0.6	1.2	-2.0	1.5
Forced expiratory volume in 1-second (FEV1)	1.6	5.2	20.8	-0.7	2.8	4.6	-0.5	1.2	0.7
Pulse rate	1.6	2.6	5.3	-0.8	0.6	1.0	-2.0	2.0	-2.3
Happiness	2.3	2.8	5.5	-2.2	0.6	2.3	-0.7	1.9	-1.3
Noisy workplace	1.4	1.8	6.0	-1.2	2.5	-0.3	0.6	-1.5	0.6
Qualifications: A levels/AS levels or equivalent	0.6	1.4	4.6	-2.1	0.3	1.1	-0.4	0.5	-1.4
Serious illness, injury or assault of a close relative in last 2 years	1.7	1.9	4.8	1.4	-2.2	-0.2	-0.7	1.6	1.3
Mouth/teeth dental problems: Dentures	0.9	1.5	4.3	-1.7	1.0	0.5	0.0	-1.0	-2.1
Asthma	1.3	2.6	7.3	2.4	-2.7	-0.7	-0.9	0.1	1.1
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.8	2.0	-1.1	0.6	1.0	0.5	-1.4	0.3
Medication: Cholesterol lowering	0.5	0.8	2.2	-1.5	1.0	0.1	-0.8	0.9	-0.5
Depression (self-reported)	2.0	2.4	3.8	1.5	-1.9	-1.0	0.4	-1.8	1.9
Medication: Lansoprazole	0.3	0.3	1.2	1.1	-0.5	0.3	-0.3	0.4	-0.1
Prospective memory result	2.7	3.3	10.4	-2.1	3.2	2.1	-0.1	0.6	-0.5
Lung cancer (father)	1.7	2.0	6.1	2.5	0.2	-1.4	1.5	-0.5	1.0
Illnesses of mother	2.2	2.7	4.5	-1.5	-0.2	-1.8	1.6	-2.1	-2.0
Forced expiratory volume in 1-second (FEV1), Best measure	1.2	3.9	17.5	-0.3	2.1	4.2	-0.5	1.0	0.4
Pulse wave Arterial Stiffness index	0.5	0.6	1.4	-0.7	0.4	0.6	-0.8	0.7	-1.2
Impedance of arm (left)	1.7	8.0	25.8	0.8	-2.5	-5.1	1.3	-2.8	-2.4
Arm fat mass (right)	1.3	5.4	12.8	-1.3	2.1	3.1	-1.5	1.1	3.6
Trunk predicted mass	4.0	23.1	86.5	-2.2	3.4	9.3	-2.8	4.1	3.4
Standing height	2.0	19.4	84.5	-2.2	3.0	9.2	-2.0	3.2	1.9
Length of working week for main job	1.4	1.5	3.0	-1.2	1.7	1.0	0.3	-0.7	-1.7
Exposure to tobacco smoke at home	1.4	1.5	5.0	1.2	0.6	-0.3	-2.2	1.5	0.2
Breastfed as a baby	0.8	1.0	3.4	-0.2	-0.7	-1.8	0.9	-1.0	0.4
Tense / ‘highly strung’	0.3	0.6	1.6	1.3	0.3	0.2	-1.0	0.7	0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	2.0	3.1	6.7	2.6	-2.5	-2.0	-0.3	-0.3	1.0
Hair/balding pattern: Pattern 4	0.3	0.6	2.3	0.6	0.3	-0.5	-1.5	0.9	-0.3
Birth weight of first child	0.5	0.9	2.8	-1.7	1.1	0.1	0.6	-0.1	0.9
Peak expiratory flow (PEF)	1.5	3.4	11.4	-1.0	2.3	3.4	-1.1	1.3	-0.1
Pulse wave reflection index	0.3	0.4	1.0	-1.0	0.9	0.5	0.0	-0.1	0.5
Ever highly irritable/argumentative for 2 days	0.8	0.9	3.8	1.2	-1.9	-0.1	0.2	0.2	0.3
Loud music exposure frequency	0.6	0.7	2.1	0.1	-0.6	-0.7	1.5	-1.0	0.5
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	2.1	0.4	-1.4	0.1	0.1	0.4	1.1
Mouth/teeth dental problems: Bleeding gums	1.6	2.1	5.1	-2.1	2.3	1.2	0.3	-0.2	-1.3
Blood clot in the leg (DVT)	0.8	1.0	2.3	1.1	-0.0	-0.1	-1.5	1.5	0.7
Medication: Paracetamol	0.6	1.0	2.4	1.4	-0.6	-0.0	-0.4	1.6	1.1
Headache pain in last month	0.0	0.1	0.2	0.3	-0.3	-0.1	0.4	0.4	-0.1
Medication for cholesterol, blood pressure or diabetes	1.2	2.0	4.9	2.2	-1.6	-1.5	0.7	-1.2	-0.2
Glaucoma (self-reported)	0.3	0.4	1.0	-0.9	0.4	0.2	0.1	-0.4	1.0
Gout (self-reported)	0.9	1.2	3.8	0.6	-0.8	0.5	-2.0	1.4	0.5
Hypothyroidism/myxoedema (self-reported)	0.6	1.2	3.3	1.1	-1.2	-0.4	0.1	-0.9	1.8
Medication: Amlodipine	0.8	1.2	3.4	-1.3	1.9	1.3	-0.4	0.3	-0.0
Medication: Ventolin 100micrograms inhaler	2.9	3.8	11.1	2.9	-3.3	-1.5	-0.9	0.2	0.4
Birth weight	0.7	1.6	2.9	-1.6	1.6	-0.3	1.7	-1.1	-0.5
Chronic bronchitis/emphysema (mother)	0.8	0.9	2.7	1.1	-0.7	-1.6	0.8	-0.7	0.1
High blood pressure (siblings)	0.9	1.3	4.7	2.2	-0.1	-0.6	-0.5	1.2	1.1
Forced vital capacity (FVC), Best measure	0.8	2.8	14.2	0.8	0.6	3.8	0.0	0.6	1.0
Body fat percentage	0.6	2.3	8.8	-0.8	1.4	-0.3	0.1	-1.5	3.0
Leg fat percentage (right)	0.8	2.7	8.2	-0.7	1.1	-1.0	1.0	-2.1	2.9
Arm fat-free mass (right)	4.6	23.5	83.9	-2.7	4.0	9.2	-2.8	3.5	3.6
Exposure to tobacco smoke outside home	0.4	0.5	1.1	0.9	-1.1	-1.0	0.0	0.3	-0.4
Comparative body size at age 10	0.3	0.7	3.3	-0.5	-0.8	0.3	-0.1	0.3	1.8
Number of full brothers	0.6	0.7	1.2	0.8	-1.1	-0.9	0.7	-0.8	0.6
Worry too long after embarrassment	0.5	0.8	2.1	-0.5	-1.5	-1.0	0.0	0.5	1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	2.0	2.6	8.7	3.0	-2.0	-0.8	-0.5	0.7	1.2
Wheeze or whistling in the chest in last year	1.1	2.0	5.1	1.6	-1.0	0.3	-2.3	1.5	-1.0
Number of children fathered	0.3	0.4	0.8	-0.6	0.3	0.9	-0.5	0.5	0.7
Reason for reducing amount of alcohol drunk: Health precaution	1.1	1.3	3.4	-0.6	-1.0	-0.3	-1.6	1.8	-0.6
Age at first live birth	1.3	2.3	5.4	-2.3	1.1	1.2	-0.8	1.2	-1.9
Pulse wave peak to peak time	0.5	0.6	2.0	0.8	-0.4	-0.0	0.6	-0.6	1.4
Health satisfaction	0.1	0.1	0.4	-0.6	-0.2	0.1	-0.2	0.4	-0.2
Shortness of breath walking on level ground	0.3	0.3	0.7	-0.8	0.6	0.8	-0.3	-0.5	0.1
Qualifications: College or University degree	2.0	6.3	12.4	-2.9	1.1	3.5	-2.2	2.2	-2.4
Eye problems/disorders: None of the above	1.5	1.7	3.4	0.9	-0.9	-1.4	1.8	-1.8	-0.1
Mouth/teeth dental problems: Loose teeth	1.4	1.6	3.9	2.0	-1.1	-1.2	-1.7	0.3	-0.4
Emphysema/chronic bronchitis	0.8	0.9	1.9	1.2	-1.1	-1.4	0.4	-0.5	0.5
Medication for pain relief, constipation, heartburn	0.2	0.3	1.0	0.6	0.2	-0.2	-0.1	0.2	-1.0
Neck or shoulder pain in last month	0.7	1.0	3.9	0.8	-0.9	-2.0	-0.1	0.5	-0.5
Medication: Blood pressure	0.9	1.5	4.2	-2.0	1.3	1.6	-0.3	0.6	0.6
Angina (self-reported)	0.2	0.2	0.7	0.3	0.8	-0.5	0.3	0.3	-0.5
Migraine (self-reported)	0.8	1.0	3.9	2.0	-0.2	0.6	-1.1	0.2	0.8
Medication: Ibuprofen	0.5	0.5	1.5	-1.1	-0.4	0.0	0.5	-1.2	-0.2
Medication: Allopurinol	0.6	0.8	2.0	-0.5	-0.1	0.7	-1.4	1.0	1.1
Medication: Omeprazole	0.3	0.3	0.6	0.7	-0.8	-0.6	-0.4	0.5	0.1
Medication: Seretide 50 evohaler	0.1	0.1	0.4	-0.1	0.5	0.0	-0.1	-0.2	-0.7
Mean time to correctly identify matches	1.4	2.6	4.1	1.1	-1.5	2.0	-1.8	1.3	1.9
Heart disease (mother)	1.3	1.5	5.1	1.9	-0.2	-0.6	-0.4	0.3	2.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	1.4	0.4	0.0	-1.2	-0.5	0.2	-0.5
Whole body fat mass	1.1	4.6	12.5	-1.4	2.2	2.6	-1.0	0.0	3.5
Leg fat mass (right)	1.0	4.0	12.4	-1.3	2.1	2.3	-0.6	-0.1	3.5
Arm predicted mass (right)	4.3	22.2	78.0	-2.7	4.2	8.8	-2.3	3.3	3.8
Pulse rate, automated reading	0.8	2.4	4.2	-0.8	2.0	2.0	-0.9	0.9	-2.0
Alcohol intake frequency.	0.5	1.2	3.8	0.9	1.0	1.2	-0.0	0.3	1.9
Comparative height size at age 10	3.5	19.5	78.5	-0.1	1.8	8.9	-3.5	4.4	2.1
Number of full sisters	0.9	1.1	3.3	-0.6	-0.7	-1.8	1.1	-1.2	-0.3
Suffer from ‘nerves’	0.8	1.3	5.0	-2.2	0.9	0.3	-0.8	0.6	-1.0
Overall health rating	1.0	2.0	6.1	1.3	-1.9	-0.3	-0.6	0.5	2.5
Chest pain or discomfort	0.7	1.1	4.0	2.0	-0.5	0.4	-1.0	1.0	0.1
Had major operations	1.3	1.5	4.7	0.6	-1.1	-0.0	-2.2	1.2	-1.1
Age at last live birth	1.5	2.2	6.5	-2.5	1.1	1.7	-0.5	0.9	-1.2
Family relationship satisfaction	1.0	1.2	4.5	-0.5	-0.0	2.1	-1.1	1.0	0.2
Leg pain on walking	0.1	0.2	0.5	-0.7	0.3	-0.7	0.0	0.0	-0.2
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	2.3	0.7	1.5	1.3	-1.0	0.5	1.0
Commuting to job workplace: Car/motor vehicle	2.0	2.3	9.9	-0.9	-0.5	-1.0	0.5	-1.2	-3.1
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.8	-0.8	1.0	1.3	0.3	-0.4	-0.3
Medication: Aspirin	0.6	0.7	3.2	-1.8	0.8	0.6	-0.1	0.3	0.3
Supplements: Vitamin C	0.7	0.8	3.0	0.7	-0.2	0.0	0.8	-0.7	1.7
Knee pain experienced in last month	1.7	2.6	8.7	1.4	-1.9	-3.0	1.1	0.0	0.4
Hypertension (Self-reported)	1.3	3.7	8.7	-0.9	0.7	3.0	-1.2	2.6	1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.3	2.2	1.0	-1.2	-0.3	-1.1	1.5	-1.3
Illnesses of father: Heart disease	0.1	0.1	0.5	0.0	-0.4	0.1	-0.2	0.4	0.7
Illnesses of siblings: Diabetes	1.1	1.4	4.0	-1.5	0.8	2.0	-0.1	1.1	-0.5
Smoking status: Previous	0.4	0.6	1.5	0.1	-0.9	-0.6	0.1	-0.8	1.2
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	2.1	-0.1	0.2	1.5	-0.7	1.2	0.7
Whole body fat-free mass	4.3	24.6	88.2	-2.3	4.0	9.4	-3.0	4.0	3.6
Leg fat-free mass (right)	4.0	21.3	71.7	-2.1	4.0	8.5	-3.1	3.5	3.7
Arm fat percentage (left)	0.5	2.0	10.1	-0.4	0.9	-0.2	-0.7	-0.6	3.2
Average weekly red wine intake	0.5	0.7	2.0	0.4	0.0	1.4	-1.0	0.5	0.9
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.2	-0.1	0.1	0.3	-0.0	-0.5	0.2
Mood swings	0.4	0.8	2.3	0.5	-1.0	-1.5	-0.2	1.1	0.1
Loneliness, isolation	0.4	0.5	2.5	0.2	0.5	0.2	0.0	-0.4	1.6
Long-standing illness, disability or infirmity	0.9	1.4	2.7	0.1	0.4	1.7	-1.5	1.1	1.5
Ever had bowel cancer screening	0.7	0.9	2.0	0.6	-1.2	-1.4	0.3	-0.3	1.1
Diabetes diagnosed by doctor	0.3	0.6	2.5	0.5	0.3	0.5	0.2	0.5	1.6
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	1.4	1.2	-0.6	-0.7	0.4	0.1	0.9
Friendships satisfaction	1.8	2.3	7.0	-2.6	0.7	1.6	0.3	0.3	-1.9
Qualifications: nursing, teaching	0.3	0.5	1.4	-1.0	-1.2	-0.5	0.5	-0.3	-0.5
Commuting to job workplace: Walk	1.4	1.5	3.2	0.8	-1.2	-1.8	0.8	-0.5	1.7
Eye problems/disorders: Cataract	2.1	2.5	4.0	-1.0	2.0	1.7	-1.8	1.9	-0.5
Mouth/teeth dental problems: Mouth ulcers	0.7	1.2	2.5	-0.3	-1.1	-0.9	0.2	1.6	-1.5
Medication for cholesterol	2.7	4.0	8.7	-0.5	0.2	-2.2	2.7	-3.0	-1.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	0.9	0.9	-0.4	0.7	0.1	-0.7	0.8
Back pain experienced in last month	0.4	0.5	2.4	-1.6	0.2	0.2	-0.7	0.3	-0.3
Mineral and other dietary supplements	2.8	3.8	8.8	-2.4	3.0	2.5	-0.1	0.1	-1.3
Breast cancer (self-reported)	0.6	0.8	1.1	0.1	1.0	1.0	-1.0	1.0	0.7
Asthma (self-reported)	1.3	2.6	7.3	2.4	-2.7	-0.6	-1.2	0.1	1.0
Osteoporosis (self-reported)	0.4	0.5	1.3	0.7	0.7	-0.2	0.8	-1.2	-0.1
Osteoarthritis (self-reported)	0.2	0.3	0.5	-0.2	0.7	-0.6	0.3	0.7	0.2
Medication: Aspirin	0.6	0.8	2.7	-1.6	0.8	1.1	-0.5	0.5	-0.0
Medication: Gliclazide	0.7	0.8	2.1	-1.5	0.4	0.6	1.2	1.0	0.0
Illnesses of father: None of the above (group 1)	0.1	0.1	0.4	-0.2	-0.3	0.2	0.5	0.1	-0.6
Smoking status: Current	0.4	0.6	1.5	0.4	-0.9	-0.0	0.2	0.9	-1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	3.6	1.9	0.5	0.4	-0.6	0.6	0.6
Whole body water mass	4.3	24.5	86.5	-2.3	3.9	9.3	-3.1	4.0	3.8
Leg predicted mass (right)	4.0	21.6	72.5	-2.1	4.0	8.5	-3.1	3.7	3.7
Arm fat mass (left)	1.3	5.5	14.5	-1.3	2.2	3.0	-1.6	0.8	3.8
Number of self-reported non-cancer illnesses	1.0	1.7	3.4	1.4	-0.9	1.2	-1.8	1.3	1.0
Average weekly champagne plus white wine intake	0.1	0.2	0.5	-0.7	0.1	0.2	0.1	0.6	-0.1
Miserableness	0.7	1.2	2.6	0.9	-1.3	-1.6	0.3	1.5	0.3
Guilty feelings	0.5	0.8	2.7	1.1	-0.1	-0.6	-0.1	0.8	1.6
Wears glasses or contact lenses	0.5	0.6	3.0	0.7	-0.1	0.3	0.2	0.1	1.7
Ever taken oral contraceptive pill	0.8	0.9	2.5	-0.9	-0.5	-1.6	0.2	-1.0	-0.9
Hearing aid user	1.2	1.4	2.4	-1.4	1.2	1.2	-1.0	1.5	0.3
Mother’s age at death	0.8	1.0	2.6	-1.0	1.6	-0.0	-1.2	0.7	-0.8
Financial situation satisfaction	0.8	1.0	2.6	-1.4	0.1	1.6	1.0	0.0	-0.6
Tinnitus: Yes, now most or all of the time	0.3	0.4	1.3	0.2	0.2	-1.1	0.2	-1.0	-0.3
Commuting to job workplace: Public transport	3.9	4.7	11.2	0.8	-1.9	1.4	-3.1	3.3	1.0
Eye problems/disorders: Glaucoma	0.8	1.0	2.0	-1.3	1.2	1.4	-0.6	0.5	0.5
Medication: Blood pressure	1.4	2.7	7.3	-0.5	0.5	2.7	-1.4	1.7	2.0
Pain type(s) experienced in last month: Hip pain	0.4	0.5	0.8	0.4	-0.7	-0.9	0.8	0.4	-0.7
Supplements: Fish oil (including cod liver oil)	2.1	2.7	5.8	2.3	-2.4	-1.7	0.1	-0.3	1.5
High cholesterol (Self-reported)	0.9	1.6	5.0	0.1	-0.2	0.6	-2.0	2.2	-0.1
Medication: Bendroflumethiazide	0.9	1.4	6.2	-0.9	0.4	0.9	0.5	-0.3	2.5
Medication: Paracetamol	0.5	0.7	1.8	1.0	-0.2	0.0	-0.1	1.3	1.2
Medication: Lisinopril	0.1	0.1	0.4	0.3	-0.3	0.1	0.1	-0.3	0.7
Medication: Atorvastatin	0.1	0.1	0.2	-0.4	-0.3	0.2	-0.3	0.2	-0.1
Illnesses of father: High blood pressure	0.1	0.1	0.3	-0.2	0.6	0.2	-0.1	-0.3	-0.4
Alcohol drinker status: Never	1.8	2.1	3.9	-0.1	1.3	1.5	-1.8	2.0	-1.3
Ever smoked	0.5	0.9	1.9	-0.5	-0.5	-0.6	1.4	-1.4	-0.9
Basal metabolic rate	4.0	22.2	76.9	-2.3	3.8	8.8	-2.9	3.5	3.9
Leg fat percentage (left)	0.8	2.8	7.9	-1.0	1.7	-0.4	0.9	-2.1	2.8
Arm fat-free mass (left)	4.2	21.4	75.3	-2.3	3.8	8.7	-2.3	3.2	4.2
Number of operations (self-reported)	0.4	0.5	1.7	1.3	0.6	-0.2	-0.8	0.2	0.7
Average weekly beer plus cider intake	2.0	2.9	8.4	0.2	-0.6	-2.9	2.0	-2.1	-0.6
Irritability	0.3	0.5	1.9	-0.1	0.5	0.0	-0.8	1.4	-0.5
Risk taking	0.5	0.8	2.9	0.1	0.1	1.7	-0.2	-0.9	-1.0
Ever had prostate specific antigen (PSA) test	0.7	0.8	3.0	-0.2	0.9	0.4	-0.7	-0.1	1.7
Fractured/broken bones in last 5 years	2.0	2.6	5.6	-1.1	1.9	1.1	-1.6	1.2	-2.4
Age started oral contraceptive pill	0.7	0.9	1.7	0.6	-1.3	-0.9	0.8	-0.4	1.3
Diastolic blood pressure, automated reading	2.4	7.3	11.0	-1.4	2.9	3.1	-3.3	3.2	-1.7
Ever depressed for a whole week	1.2	1.4	2.3	1.5	-1.3	-1.0	0.9	-0.8	1.5
Unable to work because of sickness or disability	1.0	1.3	4.5	2.1	-1.3	-1.1	0.2	-0.7	0.3
Commuting to job workplace: Cycle	0.9	1.1	2.5	-1.1	0.8	0.7	1.6	-0.0	1.2
Myopia	0.5	0.7	1.9	-0.9	0.9	-0.5	1.4	-0.3	-0.7
Vascular/heart problems diagnosed by doctor	0.8	2.1	3.7	1.3	-0.4	-1.9	0.9	-1.9	-1.6
Cholesterol lowering medication	1.3	1.9	4.5	0.6	-0.8	1.0	-2.1	1.8	1.1
Medication: Omeprazole (e.g. Zanprol)	0.3	0.3	0.9	0.9	-0.2	0.1	-0.7	0.6	0.4
Pain experienced in last month	1.2	2.0	5.4	-0.0	1.2	2.3	-1.4	0.0	1.9
Supplements: Calcium	0.5	0.6	1.7	1.3	-0.8	0.3	-0.5	-0.0	1.0
Basal cell carcinoma (self-reported)	0.1	0.1	0.3	0.6	0.5	0.1	-0.3	-0.4	0.1
Heart attack/myocardial infarction (self-reported)	1.0	1.4	2.9	-1.1	0.7	-0.8	1.7	-1.6	-0.6
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	1.8	1.3	0.2	-0.2	-1.3	1.2	0.7
Heart disease (siblings)	0.8	0.9	2.5	-0.7	0.0	1.1	-0.1	1.6	1.2
Alcohol drinker status: Previous	1.1	1.3	1.8	1.2	0.7	-1.4	1.3	-1.2	-0.8
Pack years of smoking	1.2	1.7	4.7	0.4	-0.1	1.5	-1.6	2.2	-0.7
Impedance of whole body	2.2	11.3	33.1	0.6	-2.3	-5.8	2.9	-3.8	-2.6
Leg fat mass (left)	1.2	4.5	12.0	-1.4	2.4	2.5	-0.6	-0.3	3.5
Arm predicted mass (left)	4.2	21.3	74.3	-2.3	3.9	8.6	-2.4	3.2	4.1