Hub : Genes

HINT3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.083	0.032	2.2e-04	0.019	0.024	0.028	0.025	0.027	2.0e-03	6.1e-04	2.0e-04	0.00045	2.8e-04
2	GTEx	Breast Mammary Tissue (Female)	0.389	0.096	5.8e-06	-0.008	NA	0.080	NA	0.024	6.5e-01	NA	2.2e-03	NA	6.5e-02
3	GTEx	Esophagus Muscularis	0.075	0.041	8.9e-03	-0.002	NA	0.001	NA	0.000	4.9e-01	NA	2.9e-01	NA	3.1e-01
4	GTEx	Skin Sun Exposed Lower leg	0.080	0.036	1.2e-03	0.014	NA	0.027	NA	0.028	2.3e-02	NA	2.6e-03	NA	2.0e-03
5	TCGA	Breast Invasive Carcinoma	0.041	0.018	9.4e-06	0.024	0.020	0.021	NA	0.021	8.3e-06	3.6e-05	2.6e-05	NA	3.3e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	1.6	2.6	5.1	0.7	-2.2	-1.9	-1.9	-0.3
Bipolar Disorder or Schizophrenia	0.4	1.0	2.7	-0.4	-0.9	-1.6	-1.1	0.2
Depressed Affect (Nagel 2018)	0.2	0.5	1.5	0.1	0.9	0.3	0.3	1.2
Depression (Nagel 2018)	0.5	0.7	2.4	-0.3	0.5	0.8	0.6	1.5
Intelligence (Savage-Jansen 2018)	0.7	2.2	5.4	0.3	-1.4	-1.5	-1.2	-2.3
Neuroticism (Nagel 2018)	0.4	0.9	2.5	-0.3	1.6	-0.3	1.1	0.7
Schizophrenia (2018)	0.2	0.5	1.2	-1.1	0.6	-0.6	0.1	0.6
Schizophrenia vs Biploar Disorder	0.2	0.3	1.2	1.1	-0.3	-0.1	-0.5	-0.1
Worry (Nagel 2018)	0.3	0.5	1.7	-0.6	1.3	-0.4	0.7	-0.3
Alzheimer’s Disease (in mother)	1.2	1.3	4.9	0.8	-0.9	-2.2	-0.5	0.1
Alzheimer’s Disease (in father)	0.3	0.3	1.3	-1.1	-0.0	0.4	0.3	0.3
Alzheimer’s Disease (including proxy)	0.7	1.0	3.0	-0.1	-1.4	-1.7	-0.5	0.2
Crohns Disease (2017)	0.3	0.6	2.3	-0.7	-0.4	-0.5	0.1	1.5
Irritable Bowel Disease (IBD)	0.2	0.5	1.3	-0.5	0.6	0.0	0.9	1.1
Ulcerative Colitis (UC)	0.4	0.7	1.9	-0.1	1.4	0.7	1.0	0.2
Major Depression (MDD)	1.3	1.6	3.4	-0.5	1.0	1.2	1.8	1.5
Reaction Time	0.5	0.9	2.2	-0.6	-1.1	-0.9	-0.3	1.5
Verbal and Numeric Reasoning (VNR)	0.6	1.4	3.5	-0.9	-1.9	-0.6	-1.2	-1.0
Breast Cancer	0.3	0.6	1.4	-0.4	0.3	-1.2	0.7	1.1
Ovarian Cancer	0.5	0.7	1.6	1.2	0.8	1.3	-0.0	0.1
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	1.3	1.9	3.6	0.4	-1.6	-0.4	-1.9	-1.8
Bipolar Disorder (2011)	1.8	1.7	2.7	0.3	-1.6	-1.4	-1.6	-1.1
Body Mass Index (BMI) (2010)	0.5	0.7	1.4	-0.7	-0.3	-1.2	0.5	1.1
Coronary Artery Disease (CAD)	0.5	0.6	1.9	-0.6	0.3	1.4	0.7	0.1
Crohns Disease (2012)	0.2	0.4	0.7	0.3	-0.2	-0.9	-0.6	0.8
Mean Putamen Volume	0.6	0.7	2.0	-1.4	0.3	0.6	0.7	0.8
Fasting Glucose	0.5	0.6	1.1	-0.9	0.2	-0.5	0.8	1.0
HbA1C	3.3	3.7	6.7	0.6	-2.3	-2.6	-1.9	-1.6
HDL Cholesterol	2.9	4.9	8.9	-0.4	3.0	2.7	2.5	1.3
LDL Cholesterol	0.8	1.3	3.8	-0.2	-1.3	-1.0	-0.3	1.9
Lupus	0.2	0.3	0.9	-0.5	0.9	-0.5	-0.6	-0.1
Neuroticism (2016)	0.5	0.8	1.8	0.4	1.1	-0.4	1.3	0.7
Primary Biliary Cirrhosis	0.2	0.4	1.0	-0.2	-1.0	-0.1	-0.5	0.7
Rheumatoid Arthritis	0.3	0.5	1.1	-0.2	1.0	0.1	0.9	0.7
Schizophrenia (2014)	0.5	1.0	3.0	-0.1	-0.3	-1.7	-0.9	-1.2
Triglycerides	1.6	2.6	5.7	-0.4	-2.4	-1.2	-1.9	1.4
Type 2 Diabetes (T2D) (2012)	0.5	0.6	2.9	-0.0	-1.7	-0.2	-0.3	0.3
Ulcerative Colitis	0.2	0.3	0.6	0.7	0.4	-0.8	-0.0	-0.3
Blood Eosinophil Count	0.0	0.2	0.4	0.1	-0.2	-0.7	-0.4	-0.6
Blood Platelet Count	0.6	6.5	15.8	-1.4	4.0	1.8	3.0	1.5
Blood Red Count	1.6	15.2	42.1	-0.6	-3.6	-3.7	-2.5	-6.5
Blood White Count	0.9	6.7	13.5	-2.9	3.7	0.4	3.3	0.9
Heel T-Score	2.5	19.8	33.9	4.2	-5.8	-3.7	-5.7	0.9
BMI	0.9	5.3	22.3	-1.7	-0.2	-4.7	0.2	-0.9
Height	4.0	77.1	118.8	5.8	-8.4	-9.5	-10.9	-8.5
Waist Hip Ratio (WHR)	5.0	22.3	44.9	4.0	-6.7	-3.2	-5.8	-2.5
Systolic Blood Pressure	1.7	8.4	18.2	1.5	-3.6	-1.2	-4.3	-2.7
Smoking Status	0.4	1.0	2.0	-0.9	1.0	1.4	1.0	0.6
Allergy or Eczema	0.5	1.2	2.9	-0.7	0.3	0.8	1.4	1.7
Cardiovascular Disease	4.0	13.1	20.6	2.0	-4.2	-4.5	-4.5	-1.7
Hypothyroidism (self reported)	0.1	0.1	0.4	0.2	-0.1	-0.3	0.2	0.6
Respiratory disease	1.0	2.2	7.9	0.1	-0.6	1.7	0.1	2.8
Type 2 Diabetes (T2D) (2018)	1.9	3.5	9.4	0.9	-2.0	-3.1	-1.8	-0.3
Lung FEV1/FVC ratio	0.8	4.1	16.3	-1.7	-0.9	-0.1	-0.6	-4.0
Lung FVC	0.3	1.3	2.3	1.5	0.1	-1.3	-1.3	-1.1
Neuroticism	0.3	0.6	1.2	-0.1	1.1	0.6	0.8	1.0
Chronotype (morning person)	0.5	1.2	2.0	0.8	-1.0	-1.4	-0.9	1.2
Hair Pigment	0.1	3.6	6.6	-0.9	2.2	2.6	2.4	0.2
Tanning	0.1	1.5	2.9	1.7	-1.3	0.3	-1.3	-1.0
Hand grip strength (left)	3.7	9.8	18.7	0.9	-2.2	-4.3	-3.5	-3.5
Number of treatments/medications taken	0.5	0.9	2.0	-0.2	-1.4	-1.0	-0.8	0.8
Average weekly spirits intake	1.4	1.8	3.5	1.4	-1.3	-1.0	-1.9	-0.8
Sensitivity / hurt feelings	1.4	2.4	5.4	-0.8	1.1	0.5	2.3	2.2
Frequency of depressed mood in last 2 weeks	1.4	1.9	4.1	-0.7	1.2	1.4	1.3	2.0
Hearing difficulty/problems: Yes	1.8	2.8	6.5	-2.5	1.6	0.6	1.9	0.9
Relative age of first facial hair	0.9	1.8	4.0	-2.0	1.7	0.4	1.2	-0.5
Other serious medical condition/disability diagnosed by doctor	0.5	0.6	1.7	-0.2	1.3	0.1	1.0	0.6
Ever used hormone-replacement therapy (HRT)	0.7	0.9	3.6	0.2	-0.9	0.4	-0.4	1.9
Ever had hysterectomy (womb removed)	0.6	0.7	1.6	0.3	-0.8	-1.3	-0.2	1.1
Systolic blood pressure, automated reading	0.8	2.4	4.6	0.2	-2.1	-1.4	-2.1	-1.0
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.4	0.4	-0.6	-0.4	0.1	0.5
Angina	0.1	0.2	0.4	0.4	0.3	-0.3	-0.2	-0.6
Medication for hormone replacement therapy	0.6	0.7	1.6	-1.3	-0.5	-0.2	-0.4	1.2
Vitamin and mineral supplements	0.4	0.5	1.2	0.6	-0.1	0.6	-0.8	-1.1
Supplements: Zinc	0.5	0.5	1.6	0.1	-0.7	-1.3	-0.6	0.0
Medication: Co-codamol	0.9	1.0	1.9	0.9	-1.2	1.0	-1.4	0.1
Medication: Metformin	1.3	1.8	2.4	1.3	-1.2	-1.5	-1.4	-1.2
Diabetes (father)	1.6	2.0	4.3	1.7	-2.1	-1.2	-0.8	0.8
Diabetes (mother)	3.8	4.8	10.9	1.1	-2.5	-3.3	-2.4	0.1
Severe depression (siblings)	0.4	0.4	0.9	1.0	0.5	0.3	0.8	0.5
Pack years adult smoking proportion	0.8	1.2	2.1	-0.4	-1.2	-1.4	-1.4	-0.4
Impedance of leg (right)	3.6	17.5	28.1	-2.1	5.3	5.3	4.7	2.4
Leg fat-free mass (left)	3.5	18.7	44.2	1.4	-3.9	-6.7	-4.7	-3.3
Trunk fat percentage	1.8	7.2	12.0	-3.2	3.2	-1.8	3.5	0.9
Hand grip strength (right)	4.1	11.1	23.4	1.4	-1.4	-4.2	-3.3	-4.8
Townsend deprivation index at recruitment	1.3	1.8	5.4	-2.3	1.1	-0.1	1.3	0.8
Current tobacco smoking	0.4	0.6	2.6	-0.2	0.0	1.6	-0.0	-0.5
Average weekly fortified wine intake	0.9	1.0	2.6	-1.3	-0.5	0.6	0.7	1.6
Maternal smoking around birth	1.8	2.6	3.8	-0.9	1.9	1.4	1.9	1.7
Fed-up feelings	0.2	0.4	0.9	0.9	0.6	0.2	0.2	0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.1	1.8	0.6	1.3	1.1	1.1	0.9
Relative age voice broke	1.4	2.2	4.0	-1.1	2.0	1.5	1.8	-0.5
Taking other prescription medications	1.4	2.2	8.6	-1.3	-0.1	-0.3	0.8	2.9
Age when periods started (menarche)	0.7	1.7	6.6	-0.7	0.6	1.1	0.3	-2.6
Bilateral oophorectomy (both ovaries removed)	1.9	2.2	3.7	1.6	-1.5	-1.5	-1.9	0.2
Heel bone mineral density (BMD) T-score, automated (left)	3.3	7.4	11.9	2.0	-3.2	-3.2	-3.5	0.8
Tinnitus: Yes, but not now, but have in the past	0.0	0.1	0.1	-0.4	-0.2	-0.2	-0.2	-0.1
Qualifications: CSEs or equivalent	0.1	0.2	0.4	-0.4	0.6	-0.2	0.1	0.6
Serious illness, injury or assault to yourself	0.6	0.8	1.5	-0.0	1.2	1.1	0.8	0.7
High blood pressure	3.1	8.7	15.1	2.3	-3.1	-3.5	-3.9	-1.2
Hayfever, allergic rhinitis or eczema	1.0	2.2	3.5	-1.4	0.8	1.4	1.9	1.7
Multivitamins +/- minerals	0.4	0.6	1.4	-0.3	0.7	-0.0	1.2	0.9
Stomach or abdominal pain in last month	0.3	0.3	0.7	0.7	-0.4	0.1	-0.5	-0.8
Supplements: Glucosamine	1.5	2.0	4.8	-1.3	0.6	0.6	1.7	2.2
Diverticular disease/diverticulitis (self-reported)	1.3	1.6	3.9	-0.3	1.1	2.0	0.9	-1.3
Medication: Atenolol	0.9	1.2	2.7	0.4	-0.4	-1.5	-0.9	-1.6
Medication: Levothyroxine sodium	0.6	1.1	2.7	-0.0	0.3	-1.6	0.9	1.3
Sitting height	4.1	29.3	44.0	3.5	-4.5	-6.0	-6.6	-5.8
Chronic bronchitis/emphysema (father)	0.5	0.6	1.3	-1.0	0.2	-0.7	0.5	1.1
High blood pressure (mother)	2.1	2.9	6.0	1.5	-1.9	-1.5	-2.4	0.5
Body mass index (BMI)	0.6	2.7	11.2	-1.2	0.5	-3.3	0.7	-0.1
Impedance of leg (left)	2.9	14.3	26.7	-1.6	5.2	4.6	4.3	1.7
Leg predicted mass (left)	3.5	18.6	44.0	1.4	-3.8	-6.6	-4.7	-3.2
Trunk fat mass	0.9	4.0	13.5	-1.8	1.3	-3.7	1.1	-0.4
Waist circumference	1.3	4.6	17.3	-0.6	-1.2	-4.2	-1.0	-1.7
Number of incorrect matches in round	0.3	0.5	2.0	-0.3	-0.4	0.3	-0.2	1.4
Past tobacco smoking	0.6	1.2	2.9	1.0	-1.7	-0.1	-1.2	-0.6
Alcohol usually taken with meals	0.6	0.9	2.6	-0.8	-1.1	-0.2	0.1	1.6
Nervous feelings	0.2	0.4	0.8	-0.5	0.9	0.6	0.6	0.0
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.5	1.4	-0.1	1.2	1.1	0.3	0.2
Hearing difficulty/problems with background noise	4.2	6.7	10.4	-3.2	1.9	2.1	3.0	2.5
Hair/balding pattern: Pattern 2	4.2	5.3	10.6	0.8	-3.0	-3.3	-2.2	-1.1
Had menopause	0.3	0.3	1.0	0.3	-1.0	-0.6	-0.4	0.3
Had other major operations	0.3	0.4	0.9	0.9	-0.3	-0.5	-0.6	0.7
Forced vital capacity (FVC)	3.0	11.5	22.0	2.9	-2.9	-3.8	-4.7	-2.2
Heel bone mineral density (BMD) T-score, automated (right)	2.5	5.8	8.9	2.1	-3.0	-2.5	-3.0	0.7
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	0.8	-0.1	0.5	-0.2	0.8	0.9
Qualifications: None of the above	1.0	2.1	5.3	-0.5	2.3	1.0	1.6	1.3
Financial difficulties in last 2 years	0.4	0.5	1.9	0.2	0.3	1.4	0.5	0.5
Mouth/teeth dental problems	0.5	0.7	1.9	0.8	-1.4	-0.3	-0.6	0.8
Heart attack	0.5	0.6	1.3	0.8	0.9	-0.2	-0.6	-1.2
Allergy	1.5	3.5	9.7	1.4	-0.4	-1.6	-1.8	-3.1
Pain all over the body in last month	0.9	1.0	4.2	0.1	0.7	-0.2	0.5	2.0
Diabetes (self-reported)	1.0	1.5	3.2	1.1	-1.0	-1.8	-1.3	-0.7
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	0.9	0.8	-0.5	1.0	-0.3	-0.5
Medication: Ramipril	1.8	2.4	4.5	0.0	-1.8	-2.1	-1.6	-1.2
Medication: Simvastatin	1.3	1.9	4.4	-0.8	-1.8	-2.1	-1.2	-0.3
Fluid intelligence score	0.8	1.7	5.8	-1.0	-2.4	-0.1	-1.0	-0.7
Illnesses of siblings	3.1	4.4	7.9	-1.8	2.0	2.6	2.8	-0.2
Neuroticism score	0.2	0.4	0.8	-0.1	0.6	0.1	0.9	0.9
Weight	1.9	9.5	35.0	0.3	-1.8	-5.9	-2.3	-1.9
Impedance of arm (right)	3.3	15.4	26.6	-2.5	4.3	4.6	5.2	2.1
Arm fat percentage (right)	1.2	4.7	9.0	-1.9	2.4	-1.9	3.0	1.1
Trunk fat-free mass	6.1	35.0	53.3	3.9	-6.0	-7.3	-7.3	-4.2
Hip circumference	0.9	4.1	8.0	-2.8	1.7	-2.7	1.5	-0.2
Time employed in main current job	0.5	0.6	2.6	-0.0	-0.4	-1.6	-0.4	0.4
Alcohol intake versus 10 years previously	0.2	0.4	1.3	-0.6	-0.4	0.2	-0.0	1.1
Father’s age at death	0.5	0.6	2.0	-0.9	-1.4	0.5	0.1	0.3
Worrier / anxious feelings	0.5	1.0	1.7	0.9	-1.2	-1.3	-0.8	0.5
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.3	4.2	-0.5	2.1	1.0	0.9	0.3
Falls in the last year	0.1	0.1	0.3	0.1	0.3	0.3	0.6	0.3
Hair/balding pattern: Pattern 3	5.6	8.4	10.8	-3.3	2.7	3.1	3.0	2.1
Number of live births	0.4	0.5	2.2	1.5	0.5	-0.1	-0.4	-0.2
Forced expiratory volume in 1-second (FEV1)	3.4	11.3	20.1	2.5	-2.9	-3.8	-4.5	-2.8
Pulse rate	0.3	0.5	1.5	0.0	-1.2	0.8	-0.3	-0.5
Happiness	3.6	4.4	6.2	0.9	-1.9	-2.5	-2.4	-2.4
Noisy workplace	0.9	1.1	3.4	-0.6	1.8	0.2	1.0	-1.0
Qualifications: A levels/AS levels or equivalent	0.5	1.2	2.8	0.6	-1.3	-0.3	-1.0	-1.7
Serious illness, injury or assault of a close relative in last 2 years	2.3	2.6	4.0	1.9	-2.0	-1.2	-1.7	0.9
Mouth/teeth dental problems: Dentures	0.4	0.6	1.6	0.8	0.1	-0.1	-0.9	-1.3
Asthma	1.0	1.9	8.0	-0.3	-0.1	1.1	0.5	2.8
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.2	-0.1	0.2	0.5	0.1	0.3
Medication: Cholesterol lowering	0.5	0.7	1.4	-0.8	-0.6	-1.1	-0.2	-1.2
Depression (self-reported)	2.9	3.5	5.9	-0.3	1.7	2.1	2.0	2.4
Medication: Lansoprazole	0.3	0.4	1.2	-0.7	0.2	0.2	-0.3	1.1
Prospective memory result	0.8	1.0	2.9	-0.5	0.7	-1.0	-0.7	-1.7
Lung cancer (father)	1.0	1.1	2.3	1.5	0.7	1.5	0.3	0.7
Illnesses of mother	2.3	2.9	5.0	-1.4	1.7	2.2	1.9	-1.1
Forced expiratory volume in 1-second (FEV1), Best measure	3.0	9.5	17.3	2.1	-2.8	-3.6	-4.2	-2.3
Pulse wave Arterial Stiffness index	0.7	0.8	1.9	0.6	-1.3	0.0	-1.4	-0.3
Impedance of arm (left)	4.0	18.5	29.7	-3.4	4.5	5.0	5.5	2.4
Arm fat mass (right)	0.9	3.7	17.1	-0.9	0.2	-4.1	0.3	-0.6
Trunk predicted mass	6.2	35.4	53.6	3.9	-6.0	-7.3	-7.3	-4.3
Standing height	2.9	28.5	46.2	3.2	-5.2	-6.2	-6.8	-4.5
Length of working week for main job	0.4	0.4	1.3	-0.4	0.7	-0.2	-0.1	-1.1
Exposure to tobacco smoke at home	0.9	1.0	4.8	-0.4	0.1	-0.1	0.4	2.2
Breastfed as a baby	0.2	0.2	1.0	1.0	-0.2	-0.0	0.1	-0.4
Tense / ‘highly strung’	0.3	0.6	0.9	-0.6	0.9	0.6	1.0	0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	3.1	4.7	8.3	-1.2	1.8	1.7	2.9	2.8
Hair/balding pattern: Pattern 4	4.3	10.4	18.7	-4.3	3.0	-2.7	3.8	1.5
Birth weight of first child	0.2	0.3	0.9	0.6	-0.3	1.0	-0.4	-0.3
Peak expiratory flow (PEF)	1.3	3.1	6.9	0.3	-1.1	-2.6	-2.1	-1.7
Pulse wave reflection index	1.0	1.2	1.9	1.4	-0.8	-1.0	-1.1	-1.2
Ever highly irritable/argumentative for 2 days	0.9	1.0	2.7	1.6	-0.2	-0.2	-0.6	1.4
Loud music exposure frequency	0.6	0.7	1.5	0.7	0.7	-1.2	0.0	-0.9
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.9	-0.2	-1.0	-0.1	-0.1	-0.1
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	1.5	-0.8	1.2	-0.7	0.6	-0.6
Blood clot in the leg (DVT)	0.1	0.2	0.6	0.1	-0.8	0.2	-0.3	0.2
Medication: Paracetamol	0.3	0.6	2.1	0.4	-0.5	-0.1	-0.5	1.5
Headache pain in last month	0.2	0.4	1.6	0.3	-0.4	-1.3	-0.1	0.4
Medication for cholesterol, blood pressure or diabetes	1.4	2.3	3.7	-0.3	1.5	1.9	1.5	1.9
Glaucoma (self-reported)	0.2	0.2	0.5	0.3	-0.6	0.5	-0.2	-0.7
Gout (self-reported)	0.5	0.7	1.4	-1.1	-0.2	-0.1	0.9	1.2
Hypothyroidism/myxoedema (self-reported)	0.4	0.9	1.8	-0.2	0.7	0.5	1.3	1.3
Medication: Amlodipine	1.5	2.0	4.2	0.8	-1.3	-1.2	-1.5	-2.0
Medication: Ventolin 100micrograms inhaler	2.3	3.0	8.4	-0.8	-0.3	2.9	0.6	2.3
Birth weight	0.8	1.7	3.0	-1.1	1.7	1.4	0.7	-1.3
Chronic bronchitis/emphysema (mother)	1.7	1.9	4.2	-0.4	1.7	0.5	1.5	2.0
High blood pressure (siblings)	1.8	2.6	3.7	1.4	-1.3	-1.9	-1.7	1.7
Forced vital capacity (FVC), Best measure	2.6	9.6	19.0	2.6	-2.8	-3.5	-4.4	-1.3
Body fat percentage	1.9	7.3	12.9	-2.8	3.6	-1.7	3.6	0.8
Leg fat percentage (right)	1.8	6.7	15.8	-2.0	4.0	-0.8	3.5	1.1
Arm fat-free mass (right)	5.3	27.2	52.1	2.6	-4.8	-7.2	-6.2	-4.0
Exposure to tobacco smoke outside home	1.6	2.1	3.3	-1.5	1.7	-0.3	1.5	1.8
Comparative body size at age 10	0.1	0.2	0.6	0.1	-0.8	-0.7	0.2	-0.4
Number of full brothers	0.6	0.8	2.2	0.3	0.8	0.3	1.1	1.5
Worry too long after embarrassment	0.5	0.8	2.3	0.1	0.7	-1.5	1.0	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.1	4.6	-0.7	0.0	0.4	0.6	2.1
Wheeze or whistling in the chest in last year	0.3	0.6	1.5	-0.2	-1.2	0.2	-0.2	1.1
Number of children fathered	0.2	0.2	0.3	-0.4	-0.5	-0.6	-0.1	-0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.9	2.6	-0.9	-0.1	-0.5	0.8	1.6
Age at first live birth	1.5	2.6	4.9	0.8	-1.9	-0.9	-1.8	-2.2
Pulse wave peak to peak time	0.4	0.4	1.0	-0.4	0.9	-0.4	1.0	0.1
Health satisfaction	0.1	0.2	0.4	0.4	0.6	0.2	0.2	-0.6
Shortness of breath walking on level ground	0.4	0.5	0.9	-1.0	0.9	0.6	0.6	-0.3
Qualifications: College or University degree	2.6	8.3	15.2	-0.8	-3.6	-2.6	-2.4	-3.9
Eye problems/disorders: None of the above	1.7	2.0	3.3	-1.4	1.8	1.6	1.5	0.1
Mouth/teeth dental problems: Loose teeth	4.3	5.1	8.3	-2.9	1.2	0.7	2.7	2.7
Emphysema/chronic bronchitis	0.6	0.6	1.4	0.1	0.8	0.6	1.2	0.8
Medication for pain relief, constipation, heartburn	0.2	0.3	1.0	-0.3	-0.3	0.3	-0.3	-1.0
Neck or shoulder pain in last month	1.8	2.6	4.3	-1.2	1.9	0.7	2.1	1.7
Medication: Blood pressure	0.5	0.8	1.8	-0.0	-0.5	-0.9	-1.1	-1.4
Angina (self-reported)	0.1	0.2	0.5	0.1	0.6	-0.1	0.2	-0.7
Migraine (self-reported)	1.4	1.7	6.2	-2.5	0.0	-0.6	0.8	1.1
Medication: Ibuprofen	0.3	0.4	1.2	-0.4	0.3	1.1	0.6	0.3
Medication: Allopurinol	0.8	1.1	2.4	-1.6	0.4	-0.7	1.0	1.1
Medication: Omeprazole	1.3	1.5	3.2	-1.8	0.6	-1.0	1.6	0.7
Medication: Seretide 50 evohaler	0.3	0.3	1.2	0.2	-1.1	0.1	-0.5	-0.3
Mean time to correctly identify matches	0.5	0.9	3.8	-0.5	-0.6	-0.4	0.2	1.9
Heart disease (mother)	0.9	1.1	2.1	-0.5	1.1	-0.2	1.5	1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.5	1.8	3.9	-0.5	1.5	2.0	1.1	1.1
Whole body fat mass	0.9	3.6	13.0	-1.4	1.3	-3.6	1.0	-0.5
Leg fat mass (right)	0.8	3.1	10.9	-1.1	1.5	-3.3	1.0	-0.4
Arm predicted mass (right)	4.9	25.2	49.3	2.4	-4.4	-7.0	-5.9	-4.1
Pulse rate, automated reading	0.7	2.2	3.7	1.4	-0.9	-0.9	-1.9	-1.9
Alcohol intake frequency.	1.0	2.3	9.9	0.1	-0.8	-3.2	-1.0	0.2
Comparative height size at age 10	5.2	28.4	51.0	3.1	-6.4	-6.0	-7.1	-2.4
Number of full sisters	0.9	1.1	3.7	0.1	1.9	0.3	1.1	0.6
Suffer from ‘nerves’	1.0	1.5	2.2	-0.7	1.5	1.2	1.1	-1.5
Overall health rating	0.4	0.8	3.1	-0.2	0.6	-0.2	0.7	1.8
Chest pain or discomfort	1.9	2.7	3.7	-1.7	1.9	1.8	0.6	1.8
Had major operations	0.5	0.5	1.5	-1.0	-1.2	0.0	-0.2	0.5
Age at last live birth	2.9	4.2	8.6	1.5	-2.1	-0.8	-2.3	-2.9
Family relationship satisfaction	1.6	2.0	3.2	1.1	-1.6	-1.8	-1.7	-0.4
Leg pain on walking	0.4	0.5	1.5	-0.2	0.6	1.2	0.8	0.2
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.3	0.7	-0.3	0.6	-0.7	0.8	0.2
Commuting to job workplace: Car/motor vehicle	0.5	0.5	0.9	-0.9	0.6	0.9	0.5	-0.5
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	0.9	-1.0	0.0	0.3	-0.2	-0.7
Medication: Aspirin	0.7	1.0	2.1	0.7	-0.3	-1.5	-0.7	-1.3
Supplements: Vitamin C	0.1	0.1	0.2	0.3	-0.2	-0.3	-0.4	0.0
Knee pain experienced in last month	1.2	1.9	3.4	-0.8	1.3	1.8	1.1	1.5
Hypertension (Self-reported)	3.9	11.0	18.5	2.7	-3.5	-3.9	-4.3	-1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.2	3.2	-1.8	0.3	0.3	1.0	1.2
Illnesses of father: Heart disease	0.7	1.0	2.2	-1.1	1.5	0.1	1.0	0.9
Illnesses of siblings: Diabetes	1.5	1.8	3.4	0.2	-1.3	-1.8	-1.5	-1.2
Smoking status: Previous	0.7	1.0	2.0	-0.6	1.2	0.1	1.2	1.4
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	1.3	-0.2	-0.6	-1.1	-1.2	-0.2
Whole body fat-free mass	5.3	30.4	56.4	3.0	-5.3	-7.5	-6.5	-4.1
Leg fat-free mass (right)	4.2	22.2	50.8	1.8	-4.3	-7.1	-5.1	-3.5
Arm fat percentage (left)	1.4	5.5	10.4	-2.4	2.7	-1.7	3.2	1.1
Average weekly red wine intake	0.7	1.1	2.2	1.1	-1.5	-0.1	-1.4	-0.1
Handedness (chirality/laterality): Left-handed	0.7	0.9	2.7	1.6	-0.7	0.3	-1.0	-0.5
Mood swings	0.3	0.5	0.8	0.2	0.7	0.8	0.6	0.9
Loneliness, isolation	0.3	0.4	0.7	-0.7	0.8	-0.2	0.9	0.5
Long-standing illness, disability or infirmity	0.5	0.7	2.3	-1.1	0.1	-1.5	0.2	0.1
Ever had bowel cancer screening	0.8	1.0	3.0	0.8	-0.2	1.7	0.3	1.0
Diabetes diagnosed by doctor	0.4	0.6	2.1	0.3	-0.7	-1.4	-0.6	0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.5	-0.3	0.3	-0.6	0.3	0.7
Friendships satisfaction	0.6	0.7	1.7	0.7	-0.1	-0.7	-0.9	-1.3
Qualifications: nursing, teaching	0.4	0.6	1.4	0.3	-1.2	-0.2	-0.7	-1.0
Commuting to job workplace: Walk	3.2	3.5	5.9	-1.4	2.0	1.7	2.4	1.5
Eye problems/disorders: Cataract	1.3	1.5	2.7	0.7	-1.6	-1.2	-1.6	-0.6
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.8	-0.4	0.5	0.9	0.2	-0.2
Medication for cholesterol	3.0	4.5	8.8	-0.3	3.0	2.5	2.7	-0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	2.0	1.4	0.4	-0.3	-0.1	0.4
Back pain experienced in last month	0.3	0.4	1.3	-1.1	0.4	0.3	0.5	-0.6
Mineral and other dietary supplements	2.0	2.7	8.4	0.5	-0.9	-0.9	-1.8	-2.9
Breast cancer (self-reported)	1.7	2.0	4.8	1.2	-1.5	-2.2	-1.2	-0.3
Asthma (self-reported)	0.9	1.8	7.7	-0.3	-0.3	0.9	0.5	2.8
Osteoporosis (self-reported)	0.6	0.7	2.7	0.2	0.8	1.6	0.4	0.3
Osteoarthritis (self-reported)	0.8	1.0	4.0	-0.5	-0.3	-2.0	0.2	-0.8
Medication: Aspirin	0.7	1.0	2.8	-0.1	-0.4	-1.7	-0.7	-1.1
Medication: Gliclazide	2.5	2.9	5.2	1.2	-1.6	-1.6	-2.3	-1.6
Illnesses of father: None of the above (group 1)	1.8	2.2	6.2	2.5	-1.5	-0.4	-1.3	-0.9
Smoking status: Current	0.4	0.6	2.0	-0.7	0.4	1.4	0.3	-0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	2.1	0.8	-1.0	-0.8	-1.4	0.5
Whole body water mass	5.3	30.3	56.1	3.0	-5.3	-7.5	-6.5	-4.0
Leg predicted mass (right)	4.2	22.5	51.3	1.8	-4.4	-7.2	-5.2	-3.5
Arm fat mass (left)	0.9	3.5	14.4	-1.4	0.7	-3.8	0.7	-0.4
Number of self-reported non-cancer illnesses	1.0	1.8	3.4	-0.2	-1.8	-1.8	-1.0	1.1
Average weekly champagne plus white wine intake	0.3	0.4	1.2	-1.1	0.3	0.2	0.5	-0.6
Miserableness	0.2	0.3	1.4	0.3	0.3	-0.4	-0.0	1.2
Guilty feelings	0.2	0.3	0.8	0.9	-0.5	-0.1	0.3	0.8
Wears glasses or contact lenses	0.1	0.2	0.6	-0.5	-0.0	-0.0	0.1	0.8
Ever taken oral contraceptive pill	4.0	4.5	6.6	-1.3	2.4	2.6	2.4	1.5
Hearing aid user	0.3	0.3	0.7	-0.9	-0.4	-0.2	0.5	-0.7
Mother’s age at death	0.2	0.3	0.7	-0.6	-0.5	0.3	0.0	-0.8
Financial situation satisfaction	0.5	0.7	1.5	1.1	0.2	-0.1	-1.2	-0.8
Tinnitus: Yes, now most or all of the time	1.5	1.7	3.5	-0.7	1.9	0.9	1.7	0.9
Commuting to job workplace: Public transport	2.4	2.9	7.7	0.6	-2.8	-1.7	-1.4	1.1
Eye problems/disorders: Glaucoma	1.2	1.5	2.7	0.7	-1.6	-1.1	-1.3	-1.2
Medication: Blood pressure	5.3	10.0	15.2	3.2	-3.1	-3.6	-3.9	-1.5
Pain type(s) experienced in last month: Hip pain	0.2	0.2	1.1	0.1	0.2	1.0	0.3	-0.0
Supplements: Fish oil (including cod liver oil)	0.8	1.1	4.8	0.5	-0.0	0.5	0.5	2.2
High cholesterol (Self-reported)	1.5	2.7	7.2	-0.5	-2.7	-2.0	-1.4	0.1
Medication: Bendroflumethiazide	0.5	0.8	2.1	1.0	-0.7	-1.4	-0.7	-0.1
Medication: Paracetamol	0.2	0.3	1.4	-0.3	0.0	0.3	0.1	1.2
Medication: Lisinopril	0.6	0.8	2.2	0.8	0.1	-1.5	-0.9	0.3
Medication: Atorvastatin	0.1	0.1	0.3	0.5	-0.1	-0.4	-0.3	0.1
Illnesses of father: High blood pressure	1.5	1.8	5.8	-2.4	1.1	0.7	1.1	0.7
Alcohol drinker status: Never	4.5	5.4	9.8	0.4	-3.1	-2.8	-2.4	-1.9
Ever smoked	0.6	1.1	3.8	-0.8	1.9	0.1	1.1	-0.2
Basal metabolic rate	4.4	24.2	53.6	2.3	-4.4	-7.3	-5.5	-3.6
Leg fat percentage (left)	1.5	5.5	13.3	-1.7	3.6	-1.5	3.0	0.5
Arm fat-free mass (left)	5.1	25.8	55.2	3.0	-4.3	-7.4	-5.8	-3.6
Number of operations (self-reported)	0.2	0.3	0.6	0.6	-0.6	-0.2	-0.3	0.8
Average weekly beer plus cider intake	2.3	3.3	9.3	-0.3	3.1	1.5	2.0	1.0
Irritability	0.2	0.3	0.7	-0.8	0.5	-0.0	0.6	-0.1
Risk taking	0.5	0.7	1.1	1.0	-0.4	-0.6	-1.0	-1.0
Ever had prostate specific antigen (PSA) test	0.5	0.6	2.8	-0.2	-0.0	-1.7	0.4	0.0
Fractured/broken bones in last 5 years	1.4	1.8	6.5	-2.5	0.4	0.9	0.9	-0.8
Age started oral contraceptive pill	1.0	1.2	3.5	1.9	-0.9	0.5	-1.0	0.8
Diastolic blood pressure, automated reading	0.9	2.9	6.0	0.9	-2.0	-1.6	-2.5	-1.0
Ever depressed for a whole week	0.3	0.4	0.7	0.4	0.8	-0.2	0.7	0.8
Unable to work because of sickness or disability	1.5	2.0	5.2	-1.0	1.1	1.4	0.8	2.3
Commuting to job workplace: Cycle	3.2	3.9	6.8	2.6	-1.9	-1.6	-2.0	-1.5
Myopia	1.6	2.3	3.4	1.9	-1.2	-1.1	-1.8	-1.5
Vascular/heart problems diagnosed by doctor	2.4	6.7	10.8	-2.5	2.4	2.9	3.3	1.4
Cholesterol lowering medication	2.1	3.0	6.8	0.8	-2.6	-2.0	-1.9	0.7
Medication: Omeprazole (e.g. Zanprol)	1.7	2.0	5.0	-2.2	0.7	-1.2	1.6	0.7
Pain experienced in last month	0.1	0.1	0.3	-0.3	-0.3	-0.4	-0.6	-0.2
Supplements: Calcium	1.6	1.8	2.6	-1.5	1.6	0.3	1.4	1.4
Basal cell carcinoma (self-reported)	0.2	0.2	0.7	-0.8	-0.7	-0.2	-0.2	0.1
Heart attack/myocardial infarction (self-reported)	0.5	0.7	1.5	0.6	1.2	0.1	-0.4	-1.1
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.6	0.2	-0.7	0.2	-0.3	0.2
Heart disease (siblings)	0.7	0.9	1.9	1.1	-0.7	-0.8	-1.4	-0.5
Alcohol drinker status: Previous	0.8	0.9	2.2	-1.5	1.2	0.1	0.5	0.9
Pack years of smoking	0.9	1.4	2.5	-0.4	-1.4	-1.6	-1.5	-0.1
Impedance of whole body	3.9	19.6	29.4	-2.9	5.4	5.2	5.3	2.2
Leg fat mass (left)	0.9	3.5	13.2	-1.0	1.5	-3.6	0.9	-0.7
Arm predicted mass (left)	5.1	26.1	53.1	2.9	-4.5	-7.3	-5.9	-3.7