Hub : Genes

HINT3

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.083 0.032 2.2e-04 0.019 0.024 0.028 0.025 0.027 2.0e-03 6.1e-04 2.0e-04 0.00045 2.8e-04
2 GTEx Breast Mammary Tissue (Female) 0.389 0.096 5.8e-06 -0.008 NA 0.080 NA 0.024 6.5e-01 NA 2.2e-03 NA 6.5e-02
3 GTEx Esophagus Muscularis 0.075 0.041 8.9e-03 -0.002 NA 0.001 NA 0.000 4.9e-01 NA 2.9e-01 NA 3.1e-01
4 GTEx Skin Sun Exposed Lower leg 0.080 0.036 1.2e-03 0.014 NA 0.027 NA 0.028 2.3e-02 NA 2.6e-03 NA 2.0e-03
5 TCGA Breast Invasive Carcinoma 0.041 0.018 9.4e-06 0.024 0.020 0.021 NA 0.021 8.3e-06 3.6e-05 2.6e-05 NA 3.3e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 1.6 2.6 5.1 0.7 -2.2 -1.9 -1.9 -0.3
Bipolar Disorder or Schizophrenia 0.4 1.0 2.7 -0.4 -0.9 -1.6 -1.1 0.2
Depressed Affect (Nagel 2018) 0.2 0.5 1.5 0.1 0.9 0.3 0.3 1.2
Depression (Nagel 2018) 0.5 0.7 2.4 -0.3 0.5 0.8 0.6 1.5
Intelligence (Savage-Jansen 2018) 0.7 2.2 5.4 0.3 -1.4 -1.5 -1.2 -2.3
Neuroticism (Nagel 2018) 0.4 0.9 2.5 -0.3 1.6 -0.3 1.1 0.7
Schizophrenia (2018) 0.2 0.5 1.2 -1.1 0.6 -0.6 0.1 0.6
Schizophrenia vs Biploar Disorder 0.2 0.3 1.2 1.1 -0.3 -0.1 -0.5 -0.1
Worry (Nagel 2018) 0.3 0.5 1.7 -0.6 1.3 -0.4 0.7 -0.3
Alzheimer’s Disease (in mother) 1.2 1.3 4.9 0.8 -0.9 -2.2 -0.5 0.1
Alzheimer’s Disease (in father) 0.3 0.3 1.3 -1.1 -0.0 0.4 0.3 0.3
Alzheimer’s Disease (including proxy) 0.7 1.0 3.0 -0.1 -1.4 -1.7 -0.5 0.2
Crohns Disease (2017) 0.3 0.6 2.3 -0.7 -0.4 -0.5 0.1 1.5
Irritable Bowel Disease (IBD) 0.2 0.5 1.3 -0.5 0.6 0.0 0.9 1.1
Ulcerative Colitis (UC) 0.4 0.7 1.9 -0.1 1.4 0.7 1.0 0.2
Major Depression (MDD) 1.3 1.6 3.4 -0.5 1.0 1.2 1.8 1.5
Reaction Time 0.5 0.9 2.2 -0.6 -1.1 -0.9 -0.3 1.5
Verbal and Numeric Reasoning (VNR) 0.6 1.4 3.5 -0.9 -1.9 -0.6 -1.2 -1.0
Breast Cancer 0.3 0.6 1.4 -0.4 0.3 -1.2 0.7 1.1
Ovarian Cancer 0.5 0.7 1.6 1.2 0.8 1.3 -0.0 0.1
Prostate Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Age at First Birth 1.3 1.9 3.6 0.4 -1.6 -0.4 -1.9 -1.8
Bipolar Disorder (2011) 1.8 1.7 2.7 0.3 -1.6 -1.4 -1.6 -1.1
Body Mass Index (BMI) (2010) 0.5 0.7 1.4 -0.7 -0.3 -1.2 0.5 1.1
Coronary Artery Disease (CAD) 0.5 0.6 1.9 -0.6 0.3 1.4 0.7 0.1
Crohns Disease (2012) 0.2 0.4 0.7 0.3 -0.2 -0.9 -0.6 0.8
Mean Putamen Volume 0.6 0.7 2.0 -1.4 0.3 0.6 0.7 0.8
Fasting Glucose 0.5 0.6 1.1 -0.9 0.2 -0.5 0.8 1.0
HbA1C 3.3 3.7 6.7 0.6 -2.3 -2.6 -1.9 -1.6
HDL Cholesterol 2.9 4.9 8.9 -0.4 3.0 2.7 2.5 1.3
LDL Cholesterol 0.8 1.3 3.8 -0.2 -1.3 -1.0 -0.3 1.9
Lupus 0.2 0.3 0.9 -0.5 0.9 -0.5 -0.6 -0.1
Neuroticism (2016) 0.5 0.8 1.8 0.4 1.1 -0.4 1.3 0.7
Primary Biliary Cirrhosis 0.2 0.4 1.0 -0.2 -1.0 -0.1 -0.5 0.7
Rheumatoid Arthritis 0.3 0.5 1.1 -0.2 1.0 0.1 0.9 0.7
Schizophrenia (2014) 0.5 1.0 3.0 -0.1 -0.3 -1.7 -0.9 -1.2
Triglycerides 1.6 2.6 5.7 -0.4 -2.4 -1.2 -1.9 1.4
Type 2 Diabetes (T2D) (2012) 0.5 0.6 2.9 -0.0 -1.7 -0.2 -0.3 0.3
Ulcerative Colitis 0.2 0.3 0.6 0.7 0.4 -0.8 -0.0 -0.3
Blood Eosinophil Count 0.0 0.2 0.4 0.1 -0.2 -0.7 -0.4 -0.6
Blood Platelet Count 0.6 6.5 15.8 -1.4 4.0 1.8 3.0 1.5
Blood Red Count 1.6 15.2 42.1 -0.6 -3.6 -3.7 -2.5 -6.5
Blood White Count 0.9 6.7 13.5 -2.9 3.7 0.4 3.3 0.9
Heel T-Score 2.5 19.8 33.9 4.2 -5.8 -3.7 -5.7 0.9
BMI 0.9 5.3 22.3 -1.7 -0.2 -4.7 0.2 -0.9
Height 4.0 77.1 118.8 5.8 -8.4 -9.5 -10.9 -8.5
Waist Hip Ratio (WHR) 5.0 22.3 44.9 4.0 -6.7 -3.2 -5.8 -2.5
Systolic Blood Pressure 1.7 8.4 18.2 1.5 -3.6 -1.2 -4.3 -2.7
Smoking Status 0.4 1.0 2.0 -0.9 1.0 1.4 1.0 0.6
Allergy or Eczema 0.5 1.2 2.9 -0.7 0.3 0.8 1.4 1.7
Cardiovascular Disease 4.0 13.1 20.6 2.0 -4.2 -4.5 -4.5 -1.7
Hypothyroidism (self reported) 0.1 0.1 0.4 0.2 -0.1 -0.3 0.2 0.6
Respiratory disease 1.0 2.2 7.9 0.1 -0.6 1.7 0.1 2.8
Type 2 Diabetes (T2D) (2018) 1.9 3.5 9.4 0.9 -2.0 -3.1 -1.8 -0.3
Lung FEV1/FVC ratio 0.8 4.1 16.3 -1.7 -0.9 -0.1 -0.6 -4.0
Lung FVC 0.3 1.3 2.3 1.5 0.1 -1.3 -1.3 -1.1
Neuroticism 0.3 0.6 1.2 -0.1 1.1 0.6 0.8 1.0
Chronotype (morning person) 0.5 1.2 2.0 0.8 -1.0 -1.4 -0.9 1.2
Hair Pigment 0.1 3.6 6.6 -0.9 2.2 2.6 2.4 0.2
Tanning 0.1 1.5 2.9 1.7 -1.3 0.3 -1.3 -1.0
Hand grip strength (left) 3.7 9.8 18.7 0.9 -2.2 -4.3 -3.5 -3.5
Number of treatments/medications taken 0.5 0.9 2.0 -0.2 -1.4 -1.0 -0.8 0.8
Average weekly spirits intake 1.4 1.8 3.5 1.4 -1.3 -1.0 -1.9 -0.8
Sensitivity / hurt feelings 1.4 2.4 5.4 -0.8 1.1 0.5 2.3 2.2
Frequency of depressed mood in last 2 weeks 1.4 1.9 4.1 -0.7 1.2 1.4 1.3 2.0
Hearing difficulty/problems: Yes 1.8 2.8 6.5 -2.5 1.6 0.6 1.9 0.9
Relative age of first facial hair 0.9 1.8 4.0 -2.0 1.7 0.4 1.2 -0.5
Other serious medical condition/disability diagnosed by doctor 0.5 0.6 1.7 -0.2 1.3 0.1 1.0 0.6
Ever used hormone-replacement therapy (HRT) 0.7 0.9 3.6 0.2 -0.9 0.4 -0.4 1.9
Ever had hysterectomy (womb removed) 0.6 0.7 1.6 0.3 -0.8 -1.3 -0.2 1.1
Systolic blood pressure, automated reading 0.8 2.4 4.6 0.2 -2.1 -1.4 -2.1 -1.0
Eye problems/disorders: Diabetes related eye disease 0.2 0.2 0.4 0.4 -0.6 -0.4 0.1 0.5
Angina 0.1 0.2 0.4 0.4 0.3 -0.3 -0.2 -0.6
Medication for hormone replacement therapy 0.6 0.7 1.6 -1.3 -0.5 -0.2 -0.4 1.2
Vitamin and mineral supplements 0.4 0.5 1.2 0.6 -0.1 0.6 -0.8 -1.1
Supplements: Zinc 0.5 0.5 1.6 0.1 -0.7 -1.3 -0.6 0.0
Medication: Co-codamol 0.9 1.0 1.9 0.9 -1.2 1.0 -1.4 0.1
Medication: Metformin 1.3 1.8 2.4 1.3 -1.2 -1.5 -1.4 -1.2
Diabetes (father) 1.6 2.0 4.3 1.7 -2.1 -1.2 -0.8 0.8
Diabetes (mother) 3.8 4.8 10.9 1.1 -2.5 -3.3 -2.4 0.1
Severe depression (siblings) 0.4 0.4 0.9 1.0 0.5 0.3 0.8 0.5
Pack years adult smoking proportion 0.8 1.2 2.1 -0.4 -1.2 -1.4 -1.4 -0.4
Impedance of leg (right) 3.6 17.5 28.1 -2.1 5.3 5.3 4.7 2.4
Leg fat-free mass (left) 3.5 18.7 44.2 1.4 -3.9 -6.7 -4.7 -3.3
Trunk fat percentage 1.8 7.2 12.0 -3.2 3.2 -1.8 3.5 0.9
Hand grip strength (right) 4.1 11.1 23.4 1.4 -1.4 -4.2 -3.3 -4.8
Townsend deprivation index at recruitment 1.3 1.8 5.4 -2.3 1.1 -0.1 1.3 0.8
Current tobacco smoking 0.4 0.6 2.6 -0.2 0.0 1.6 -0.0 -0.5
Average weekly fortified wine intake 0.9 1.0 2.6 -1.3 -0.5 0.6 0.7 1.6
Maternal smoking around birth 1.8 2.6 3.8 -0.9 1.9 1.4 1.9 1.7
Fed-up feelings 0.2 0.4 0.9 0.9 0.6 0.2 0.2 0.8
Frequency of unenthusiasm / disinterest in last 2 weeks 0.8 1.1 1.8 0.6 1.3 1.1 1.1 0.9
Relative age voice broke 1.4 2.2 4.0 -1.1 2.0 1.5 1.8 -0.5
Taking other prescription medications 1.4 2.2 8.6 -1.3 -0.1 -0.3 0.8 2.9
Age when periods started (menarche) 0.7 1.7 6.6 -0.7 0.6 1.1 0.3 -2.6
Bilateral oophorectomy (both ovaries removed) 1.9 2.2 3.7 1.6 -1.5 -1.5 -1.9 0.2
Heel bone mineral density (BMD) T-score, automated (left) 3.3 7.4 11.9 2.0 -3.2 -3.2 -3.5 0.8
Tinnitus: Yes, but not now, but have in the past 0.0 0.1 0.1 -0.4 -0.2 -0.2 -0.2 -0.1
Qualifications: CSEs or equivalent 0.1 0.2 0.4 -0.4 0.6 -0.2 0.1 0.6
Serious illness, injury or assault to yourself 0.6 0.8 1.5 -0.0 1.2 1.1 0.8 0.7
High blood pressure 3.1 8.7 15.1 2.3 -3.1 -3.5 -3.9 -1.2
Hayfever, allergic rhinitis or eczema 1.0 2.2 3.5 -1.4 0.8 1.4 1.9 1.7
Multivitamins +/- minerals 0.4 0.6 1.4 -0.3 0.7 -0.0 1.2 0.9
Stomach or abdominal pain in last month 0.3 0.3 0.7 0.7 -0.4 0.1 -0.5 -0.8
Supplements: Glucosamine 1.5 2.0 4.8 -1.3 0.6 0.6 1.7 2.2
Diverticular disease/diverticulitis (self-reported) 1.3 1.6 3.9 -0.3 1.1 2.0 0.9 -1.3
Medication: Atenolol 0.9 1.2 2.7 0.4 -0.4 -1.5 -0.9 -1.6
Medication: Levothyroxine sodium 0.6 1.1 2.7 -0.0 0.3 -1.6 0.9 1.3
Sitting height 4.1 29.3 44.0 3.5 -4.5 -6.0 -6.6 -5.8
Chronic bronchitis/emphysema (father) 0.5 0.6 1.3 -1.0 0.2 -0.7 0.5 1.1
High blood pressure (mother) 2.1 2.9 6.0 1.5 -1.9 -1.5 -2.4 0.5
Body mass index (BMI) 0.6 2.7 11.2 -1.2 0.5 -3.3 0.7 -0.1
Impedance of leg (left) 2.9 14.3 26.7 -1.6 5.2 4.6 4.3 1.7
Leg predicted mass (left) 3.5 18.6 44.0 1.4 -3.8 -6.6 -4.7 -3.2
Trunk fat mass 0.9 4.0 13.5 -1.8 1.3 -3.7 1.1 -0.4
Waist circumference 1.3 4.6 17.3 -0.6 -1.2 -4.2 -1.0 -1.7
Number of incorrect matches in round 0.3 0.5 2.0 -0.3 -0.4 0.3 -0.2 1.4
Past tobacco smoking 0.6 1.2 2.9 1.0 -1.7 -0.1 -1.2 -0.6
Alcohol usually taken with meals 0.6 0.9 2.6 -0.8 -1.1 -0.2 0.1 1.6
Nervous feelings 0.2 0.4 0.8 -0.5 0.9 0.6 0.6 0.0
Frequency of tenseness / restlessness in last 2 weeks 0.4 0.5 1.4 -0.1 1.2 1.1 0.3 0.2
Hearing difficulty/problems with background noise 4.2 6.7 10.4 -3.2 1.9 2.1 3.0 2.5
Hair/balding pattern: Pattern 2 4.2 5.3 10.6 0.8 -3.0 -3.3 -2.2 -1.1
Had menopause 0.3 0.3 1.0 0.3 -1.0 -0.6 -0.4 0.3
Had other major operations 0.3 0.4 0.9 0.9 -0.3 -0.5 -0.6 0.7
Forced vital capacity (FVC) 3.0 11.5 22.0 2.9 -2.9 -3.8 -4.7 -2.2
Heel bone mineral density (BMD) T-score, automated (right) 2.5 5.8 8.9 2.1 -3.0 -2.5 -3.0 0.7
Ever unenthusiastic/disinterested for a whole week 0.3 0.4 0.8 -0.1 0.5 -0.2 0.8 0.9
Qualifications: None of the above 1.0 2.1 5.3 -0.5 2.3 1.0 1.6 1.3
Financial difficulties in last 2 years 0.4 0.5 1.9 0.2 0.3 1.4 0.5 0.5
Mouth/teeth dental problems 0.5 0.7 1.9 0.8 -1.4 -0.3 -0.6 0.8
Heart attack 0.5 0.6 1.3 0.8 0.9 -0.2 -0.6 -1.2
Allergy 1.5 3.5 9.7 1.4 -0.4 -1.6 -1.8 -3.1
Pain all over the body in last month 0.9 1.0 4.2 0.1 0.7 -0.2 0.5 2.0
Diabetes (self-reported) 1.0 1.5 3.2 1.1 -1.0 -1.8 -1.3 -0.7
Hayfever/allergic rhinitis (self-reported) 0.3 0.4 0.9 0.8 -0.5 1.0 -0.3 -0.5
Medication: Ramipril 1.8 2.4 4.5 0.0 -1.8 -2.1 -1.6 -1.2
Medication: Simvastatin 1.3 1.9 4.4 -0.8 -1.8 -2.1 -1.2 -0.3
Fluid intelligence score 0.8 1.7 5.8 -1.0 -2.4 -0.1 -1.0 -0.7
Illnesses of siblings 3.1 4.4 7.9 -1.8 2.0 2.6 2.8 -0.2
Neuroticism score 0.2 0.4 0.8 -0.1 0.6 0.1 0.9 0.9
Weight 1.9 9.5 35.0 0.3 -1.8 -5.9 -2.3 -1.9
Impedance of arm (right) 3.3 15.4 26.6 -2.5 4.3 4.6 5.2 2.1
Arm fat percentage (right) 1.2 4.7 9.0 -1.9 2.4 -1.9 3.0 1.1
Trunk fat-free mass 6.1 35.0 53.3 3.9 -6.0 -7.3 -7.3 -4.2
Hip circumference 0.9 4.1 8.0 -2.8 1.7 -2.7 1.5 -0.2
Time employed in main current job 0.5 0.6 2.6 -0.0 -0.4 -1.6 -0.4 0.4
Alcohol intake versus 10 years previously 0.2 0.4 1.3 -0.6 -0.4 0.2 -0.0 1.1
Father’s age at death 0.5 0.6 2.0 -0.9 -1.4 0.5 0.1 0.3
Worrier / anxious feelings 0.5 1.0 1.7 0.9 -1.2 -1.3 -0.8 0.5
Frequency of tiredness / lethargy in last 2 weeks 0.8 1.3 4.2 -0.5 2.1 1.0 0.9 0.3
Falls in the last year 0.1 0.1 0.3 0.1 0.3 0.3 0.6 0.3
Hair/balding pattern: Pattern 3 5.6 8.4 10.8 -3.3 2.7 3.1 3.0 2.1
Number of live births 0.4 0.5 2.2 1.5 0.5 -0.1 -0.4 -0.2
Forced expiratory volume in 1-second (FEV1) 3.4 11.3 20.1 2.5 -2.9 -3.8 -4.5 -2.8
Pulse rate 0.3 0.5 1.5 0.0 -1.2 0.8 -0.3 -0.5
Happiness 3.6 4.4 6.2 0.9 -1.9 -2.5 -2.4 -2.4
Noisy workplace 0.9 1.1 3.4 -0.6 1.8 0.2 1.0 -1.0
Qualifications: A levels/AS levels or equivalent 0.5 1.2 2.8 0.6 -1.3 -0.3 -1.0 -1.7
Serious illness, injury or assault of a close relative in last 2 years 2.3 2.6 4.0 1.9 -2.0 -1.2 -1.7 0.9
Mouth/teeth dental problems: Dentures 0.4 0.6 1.6 0.8 0.1 -0.1 -0.9 -1.3
Asthma 1.0 1.9 8.0 -0.3 -0.1 1.1 0.5 2.8
Medication: Ibuprofen (e.g. Nurofen) 0.1 0.1 0.2 -0.1 0.2 0.5 0.1 0.3
Medication: Cholesterol lowering 0.5 0.7 1.4 -0.8 -0.6 -1.1 -0.2 -1.2
Depression (self-reported) 2.9 3.5 5.9 -0.3 1.7 2.1 2.0 2.4
Medication: Lansoprazole 0.3 0.4 1.2 -0.7 0.2 0.2 -0.3 1.1
Prospective memory result 0.8 1.0 2.9 -0.5 0.7 -1.0 -0.7 -1.7
Lung cancer (father) 1.0 1.1 2.3 1.5 0.7 1.5 0.3 0.7
Illnesses of mother 2.3 2.9 5.0 -1.4 1.7 2.2 1.9 -1.1
Forced expiratory volume in 1-second (FEV1), Best measure 3.0 9.5 17.3 2.1 -2.8 -3.6 -4.2 -2.3
Pulse wave Arterial Stiffness index 0.7 0.8 1.9 0.6 -1.3 0.0 -1.4 -0.3
Impedance of arm (left) 4.0 18.5 29.7 -3.4 4.5 5.0 5.5 2.4
Arm fat mass (right) 0.9 3.7 17.1 -0.9 0.2 -4.1 0.3 -0.6
Trunk predicted mass 6.2 35.4 53.6 3.9 -6.0 -7.3 -7.3 -4.3
Standing height 2.9 28.5 46.2 3.2 -5.2 -6.2 -6.8 -4.5
Length of working week for main job 0.4 0.4 1.3 -0.4 0.7 -0.2 -0.1 -1.1
Exposure to tobacco smoke at home 0.9 1.0 4.8 -0.4 0.1 -0.1 0.4 2.2
Breastfed as a baby 0.2 0.2 1.0 1.0 -0.2 -0.0 0.1 -0.4
Tense / ‘highly strung’ 0.3 0.6 0.9 -0.6 0.9 0.6 1.0 0.7
Seen doctor (GP) for nerves, anxiety, tension or depression 3.1 4.7 8.3 -1.2 1.8 1.7 2.9 2.8
Hair/balding pattern: Pattern 4 4.3 10.4 18.7 -4.3 3.0 -2.7 3.8 1.5
Birth weight of first child 0.2 0.3 0.9 0.6 -0.3 1.0 -0.4 -0.3
Peak expiratory flow (PEF) 1.3 3.1 6.9 0.3 -1.1 -2.6 -2.1 -1.7
Pulse wave reflection index 1.0 1.2 1.9 1.4 -0.8 -1.0 -1.1 -1.2
Ever highly irritable/argumentative for 2 days 0.9 1.0 2.7 1.6 -0.2 -0.2 -0.6 1.4
Loud music exposure frequency 0.6 0.7 1.5 0.7 0.7 -1.2 0.0 -0.9
Qualifications: O levels/GCSEs or equivalent 0.1 0.2 0.9 -0.2 -1.0 -0.1 -0.1 -0.1
Mouth/teeth dental problems: Bleeding gums 0.5 0.7 1.5 -0.8 1.2 -0.7 0.6 -0.6
Blood clot in the leg (DVT) 0.1 0.2 0.6 0.1 -0.8 0.2 -0.3 0.2
Medication: Paracetamol 0.3 0.6 2.1 0.4 -0.5 -0.1 -0.5 1.5
Headache pain in last month 0.2 0.4 1.6 0.3 -0.4 -1.3 -0.1 0.4
Medication for cholesterol, blood pressure or diabetes 1.4 2.3 3.7 -0.3 1.5 1.9 1.5 1.9
Glaucoma (self-reported) 0.2 0.2 0.5 0.3 -0.6 0.5 -0.2 -0.7
Gout (self-reported) 0.5 0.7 1.4 -1.1 -0.2 -0.1 0.9 1.2
Hypothyroidism/myxoedema (self-reported) 0.4 0.9 1.8 -0.2 0.7 0.5 1.3 1.3
Medication: Amlodipine 1.5 2.0 4.2 0.8 -1.3 -1.2 -1.5 -2.0
Medication: Ventolin 100micrograms inhaler 2.3 3.0 8.4 -0.8 -0.3 2.9 0.6 2.3
Birth weight 0.8 1.7 3.0 -1.1 1.7 1.4 0.7 -1.3
Chronic bronchitis/emphysema (mother) 1.7 1.9 4.2 -0.4 1.7 0.5 1.5 2.0
High blood pressure (siblings) 1.8 2.6 3.7 1.4 -1.3 -1.9 -1.7 1.7
Forced vital capacity (FVC), Best measure 2.6 9.6 19.0 2.6 -2.8 -3.5 -4.4 -1.3
Body fat percentage 1.9 7.3 12.9 -2.8 3.6 -1.7 3.6 0.8
Leg fat percentage (right) 1.8 6.7 15.8 -2.0 4.0 -0.8 3.5 1.1
Arm fat-free mass (right) 5.3 27.2 52.1 2.6 -4.8 -7.2 -6.2 -4.0
Exposure to tobacco smoke outside home 1.6 2.1 3.3 -1.5 1.7 -0.3 1.5 1.8
Comparative body size at age 10 0.1 0.2 0.6 0.1 -0.8 -0.7 0.2 -0.4
Number of full brothers 0.6 0.8 2.2 0.3 0.8 0.3 1.1 1.5
Worry too long after embarrassment 0.5 0.8 2.3 0.1 0.7 -1.5 1.0 0.3
Seen a psychiatrist for nerves, anxiety, tension or depression 0.9 1.1 4.6 -0.7 0.0 0.4 0.6 2.1
Wheeze or whistling in the chest in last year 0.3 0.6 1.5 -0.2 -1.2 0.2 -0.2 1.1
Number of children fathered 0.2 0.2 0.3 -0.4 -0.5 -0.6 -0.1 -0.4
Reason for reducing amount of alcohol drunk: Health precaution 0.7 0.9 2.6 -0.9 -0.1 -0.5 0.8 1.6
Age at first live birth 1.5 2.6 4.9 0.8 -1.9 -0.9 -1.8 -2.2
Pulse wave peak to peak time 0.4 0.4 1.0 -0.4 0.9 -0.4 1.0 0.1
Health satisfaction 0.1 0.2 0.4 0.4 0.6 0.2 0.2 -0.6
Shortness of breath walking on level ground 0.4 0.5 0.9 -1.0 0.9 0.6 0.6 -0.3
Qualifications: College or University degree 2.6 8.3 15.2 -0.8 -3.6 -2.6 -2.4 -3.9
Eye problems/disorders: None of the above 1.7 2.0 3.3 -1.4 1.8 1.6 1.5 0.1
Mouth/teeth dental problems: Loose teeth 4.3 5.1 8.3 -2.9 1.2 0.7 2.7 2.7
Emphysema/chronic bronchitis 0.6 0.6 1.4 0.1 0.8 0.6 1.2 0.8
Medication for pain relief, constipation, heartburn 0.2 0.3 1.0 -0.3 -0.3 0.3 -0.3 -1.0
Neck or shoulder pain in last month 1.8 2.6 4.3 -1.2 1.9 0.7 2.1 1.7
Medication: Blood pressure 0.5 0.8 1.8 -0.0 -0.5 -0.9 -1.1 -1.4
Angina (self-reported) 0.1 0.2 0.5 0.1 0.6 -0.1 0.2 -0.7
Migraine (self-reported) 1.4 1.7 6.2 -2.5 0.0 -0.6 0.8 1.1
Medication: Ibuprofen 0.3 0.4 1.2 -0.4 0.3 1.1 0.6 0.3
Medication: Allopurinol 0.8 1.1 2.4 -1.6 0.4 -0.7 1.0 1.1
Medication: Omeprazole 1.3 1.5 3.2 -1.8 0.6 -1.0 1.6 0.7
Medication: Seretide 50 evohaler 0.3 0.3 1.2 0.2 -1.1 0.1 -0.5 -0.3
Mean time to correctly identify matches 0.5 0.9 3.8 -0.5 -0.6 -0.4 0.2 1.9
Heart disease (mother) 0.9 1.1 2.1 -0.5 1.1 -0.2 1.5 1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.5 1.8 3.9 -0.5 1.5 2.0 1.1 1.1
Whole body fat mass 0.9 3.6 13.0 -1.4 1.3 -3.6 1.0 -0.5
Leg fat mass (right) 0.8 3.1 10.9 -1.1 1.5 -3.3 1.0 -0.4
Arm predicted mass (right) 4.9 25.2 49.3 2.4 -4.4 -7.0 -5.9 -4.1
Pulse rate, automated reading 0.7 2.2 3.7 1.4 -0.9 -0.9 -1.9 -1.9
Alcohol intake frequency. 1.0 2.3 9.9 0.1 -0.8 -3.2 -1.0 0.2
Comparative height size at age 10 5.2 28.4 51.0 3.1 -6.4 -6.0 -7.1 -2.4
Number of full sisters 0.9 1.1 3.7 0.1 1.9 0.3 1.1 0.6
Suffer from ‘nerves’ 1.0 1.5 2.2 -0.7 1.5 1.2 1.1 -1.5
Overall health rating 0.4 0.8 3.1 -0.2 0.6 -0.2 0.7 1.8
Chest pain or discomfort 1.9 2.7 3.7 -1.7 1.9 1.8 0.6 1.8
Had major operations 0.5 0.5 1.5 -1.0 -1.2 0.0 -0.2 0.5
Age at last live birth 2.9 4.2 8.6 1.5 -2.1 -0.8 -2.3 -2.9
Family relationship satisfaction 1.6 2.0 3.2 1.1 -1.6 -1.8 -1.7 -0.4
Leg pain on walking 0.4 0.5 1.5 -0.2 0.6 1.2 0.8 0.2
Qualifications: NVQ or HND or HNC or equivalent 0.3 0.3 0.7 -0.3 0.6 -0.7 0.8 0.2
Commuting to job workplace: Car/motor vehicle 0.5 0.5 0.9 -0.9 0.6 0.9 0.5 -0.5
Illness, injury, bereavement, stress in last 2 years 0.2 0.3 0.9 -1.0 0.0 0.3 -0.2 -0.7
Medication: Aspirin 0.7 1.0 2.1 0.7 -0.3 -1.5 -0.7 -1.3
Supplements: Vitamin C 0.1 0.1 0.2 0.3 -0.2 -0.3 -0.4 0.0
Knee pain experienced in last month 1.2 1.9 3.4 -0.8 1.3 1.8 1.1 1.5
Hypertension (Self-reported) 3.9 11.0 18.5 2.7 -3.5 -3.9 -4.3 -1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.0 1.2 3.2 -1.8 0.3 0.3 1.0 1.2
Illnesses of father: Heart disease 0.7 1.0 2.2 -1.1 1.5 0.1 1.0 0.9
Illnesses of siblings: Diabetes 1.5 1.8 3.4 0.2 -1.3 -1.8 -1.5 -1.2
Smoking status: Previous 0.7 1.0 2.0 -0.6 1.2 0.1 1.2 1.4
Forced expiratory volume in 1-second (FEV1), predicted 0.3 0.6 1.3 -0.2 -0.6 -1.1 -1.2 -0.2
Whole body fat-free mass 5.3 30.4 56.4 3.0 -5.3 -7.5 -6.5 -4.1
Leg fat-free mass (right) 4.2 22.2 50.8 1.8 -4.3 -7.1 -5.1 -3.5
Arm fat percentage (left) 1.4 5.5 10.4 -2.4 2.7 -1.7 3.2 1.1
Average weekly red wine intake 0.7 1.1 2.2 1.1 -1.5 -0.1 -1.4 -0.1
Handedness (chirality/laterality): Left-handed 0.7 0.9 2.7 1.6 -0.7 0.3 -1.0 -0.5
Mood swings 0.3 0.5 0.8 0.2 0.7 0.8 0.6 0.9
Loneliness, isolation 0.3 0.4 0.7 -0.7 0.8 -0.2 0.9 0.5
Long-standing illness, disability or infirmity 0.5 0.7 2.3 -1.1 0.1 -1.5 0.2 0.1
Ever had bowel cancer screening 0.8 1.0 3.0 0.8 -0.2 1.7 0.3 1.0
Diabetes diagnosed by doctor 0.4 0.6 2.1 0.3 -0.7 -1.4 -0.6 0.2
Ever had stillbirth, spontaneous miscarriage or termination 0.2 0.2 0.5 -0.3 0.3 -0.6 0.3 0.7
Friendships satisfaction 0.6 0.7 1.7 0.7 -0.1 -0.7 -0.9 -1.3
Qualifications: nursing, teaching 0.4 0.6 1.4 0.3 -1.2 -0.2 -0.7 -1.0
Commuting to job workplace: Walk 3.2 3.5 5.9 -1.4 2.0 1.7 2.4 1.5
Eye problems/disorders: Cataract 1.3 1.5 2.7 0.7 -1.6 -1.2 -1.6 -0.6
Mouth/teeth dental problems: Mouth ulcers 0.2 0.3 0.8 -0.4 0.5 0.9 0.2 -0.2
Medication for cholesterol 3.0 4.5 8.8 -0.3 3.0 2.5 2.7 -0.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.4 0.5 2.0 1.4 0.4 -0.3 -0.1 0.4
Back pain experienced in last month 0.3 0.4 1.3 -1.1 0.4 0.3 0.5 -0.6
Mineral and other dietary supplements 2.0 2.7 8.4 0.5 -0.9 -0.9 -1.8 -2.9
Breast cancer (self-reported) 1.7 2.0 4.8 1.2 -1.5 -2.2 -1.2 -0.3
Asthma (self-reported) 0.9 1.8 7.7 -0.3 -0.3 0.9 0.5 2.8
Osteoporosis (self-reported) 0.6 0.7 2.7 0.2 0.8 1.6 0.4 0.3
Osteoarthritis (self-reported) 0.8 1.0 4.0 -0.5 -0.3 -2.0 0.2 -0.8
Medication: Aspirin 0.7 1.0 2.8 -0.1 -0.4 -1.7 -0.7 -1.1
Medication: Gliclazide 2.5 2.9 5.2 1.2 -1.6 -1.6 -2.3 -1.6
Illnesses of father: None of the above (group 1) 1.8 2.2 6.2 2.5 -1.5 -0.4 -1.3 -0.9
Smoking status: Current 0.4 0.6 2.0 -0.7 0.4 1.4 0.3 -0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.9 2.1 0.8 -1.0 -0.8 -1.4 0.5
Whole body water mass 5.3 30.3 56.1 3.0 -5.3 -7.5 -6.5 -4.0
Leg predicted mass (right) 4.2 22.5 51.3 1.8 -4.4 -7.2 -5.2 -3.5
Arm fat mass (left) 0.9 3.5 14.4 -1.4 0.7 -3.8 0.7 -0.4
Number of self-reported non-cancer illnesses 1.0 1.8 3.4 -0.2 -1.8 -1.8 -1.0 1.1
Average weekly champagne plus white wine intake 0.3 0.4 1.2 -1.1 0.3 0.2 0.5 -0.6
Miserableness 0.2 0.3 1.4 0.3 0.3 -0.4 -0.0 1.2
Guilty feelings 0.2 0.3 0.8 0.9 -0.5 -0.1 0.3 0.8
Wears glasses or contact lenses 0.1 0.2 0.6 -0.5 -0.0 -0.0 0.1 0.8
Ever taken oral contraceptive pill 4.0 4.5 6.6 -1.3 2.4 2.6 2.4 1.5
Hearing aid user 0.3 0.3 0.7 -0.9 -0.4 -0.2 0.5 -0.7
Mother’s age at death 0.2 0.3 0.7 -0.6 -0.5 0.3 0.0 -0.8
Financial situation satisfaction 0.5 0.7 1.5 1.1 0.2 -0.1 -1.2 -0.8
Tinnitus: Yes, now most or all of the time 1.5 1.7 3.5 -0.7 1.9 0.9 1.7 0.9
Commuting to job workplace: Public transport 2.4 2.9 7.7 0.6 -2.8 -1.7 -1.4 1.1
Eye problems/disorders: Glaucoma 1.2 1.5 2.7 0.7 -1.6 -1.1 -1.3 -1.2
Medication: Blood pressure 5.3 10.0 15.2 3.2 -3.1 -3.6 -3.9 -1.5
Pain type(s) experienced in last month: Hip pain 0.2 0.2 1.1 0.1 0.2 1.0 0.3 -0.0
Supplements: Fish oil (including cod liver oil) 0.8 1.1 4.8 0.5 -0.0 0.5 0.5 2.2
High cholesterol (Self-reported) 1.5 2.7 7.2 -0.5 -2.7 -2.0 -1.4 0.1
Medication: Bendroflumethiazide 0.5 0.8 2.1 1.0 -0.7 -1.4 -0.7 -0.1
Medication: Paracetamol 0.2 0.3 1.4 -0.3 0.0 0.3 0.1 1.2
Medication: Lisinopril 0.6 0.8 2.2 0.8 0.1 -1.5 -0.9 0.3
Medication: Atorvastatin 0.1 0.1 0.3 0.5 -0.1 -0.4 -0.3 0.1
Illnesses of father: High blood pressure 1.5 1.8 5.8 -2.4 1.1 0.7 1.1 0.7
Alcohol drinker status: Never 4.5 5.4 9.8 0.4 -3.1 -2.8 -2.4 -1.9
Ever smoked 0.6 1.1 3.8 -0.8 1.9 0.1 1.1 -0.2
Basal metabolic rate 4.4 24.2 53.6 2.3 -4.4 -7.3 -5.5 -3.6
Leg fat percentage (left) 1.5 5.5 13.3 -1.7 3.6 -1.5 3.0 0.5
Arm fat-free mass (left) 5.1 25.8 55.2 3.0 -4.3 -7.4 -5.8 -3.6
Number of operations (self-reported) 0.2 0.3 0.6 0.6 -0.6 -0.2 -0.3 0.8
Average weekly beer plus cider intake 2.3 3.3 9.3 -0.3 3.1 1.5 2.0 1.0
Irritability 0.2 0.3 0.7 -0.8 0.5 -0.0 0.6 -0.1
Risk taking 0.5 0.7 1.1 1.0 -0.4 -0.6 -1.0 -1.0
Ever had prostate specific antigen (PSA) test 0.5 0.6 2.8 -0.2 -0.0 -1.7 0.4 0.0
Fractured/broken bones in last 5 years 1.4 1.8 6.5 -2.5 0.4 0.9 0.9 -0.8
Age started oral contraceptive pill 1.0 1.2 3.5 1.9 -0.9 0.5 -1.0 0.8
Diastolic blood pressure, automated reading 0.9 2.9 6.0 0.9 -2.0 -1.6 -2.5 -1.0
Ever depressed for a whole week 0.3 0.4 0.7 0.4 0.8 -0.2 0.7 0.8
Unable to work because of sickness or disability 1.5 2.0 5.2 -1.0 1.1 1.4 0.8 2.3
Commuting to job workplace: Cycle 3.2 3.9 6.8 2.6 -1.9 -1.6 -2.0 -1.5
Myopia 1.6 2.3 3.4 1.9 -1.2 -1.1 -1.8 -1.5
Vascular/heart problems diagnosed by doctor 2.4 6.7 10.8 -2.5 2.4 2.9 3.3 1.4
Cholesterol lowering medication 2.1 3.0 6.8 0.8 -2.6 -2.0 -1.9 0.7
Medication: Omeprazole (e.g. Zanprol) 1.7 2.0 5.0 -2.2 0.7 -1.2 1.6 0.7
Pain experienced in last month 0.1 0.1 0.3 -0.3 -0.3 -0.4 -0.6 -0.2
Supplements: Calcium 1.6 1.8 2.6 -1.5 1.6 0.3 1.4 1.4
Basal cell carcinoma (self-reported) 0.2 0.2 0.7 -0.8 -0.7 -0.2 -0.2 0.1
Heart attack/myocardial infarction (self-reported) 0.5 0.7 1.5 0.6 1.2 0.1 -0.4 -1.1
Deep venous thrombosis (DVT) (self-reported) 0.1 0.1 0.6 0.2 -0.7 0.2 -0.3 0.2
Heart disease (siblings) 0.7 0.9 1.9 1.1 -0.7 -0.8 -1.4 -0.5
Alcohol drinker status: Previous 0.8 0.9 2.2 -1.5 1.2 0.1 0.5 0.9
Pack years of smoking 0.9 1.4 2.5 -0.4 -1.4 -1.6 -1.5 -0.1
Impedance of whole body 3.9 19.6 29.4 -2.9 5.4 5.2 5.3 2.2
Leg fat mass (left) 0.9 3.5 13.2 -1.0 1.5 -3.6 0.9 -0.7
Arm predicted mass (left) 5.1 26.1 53.1 2.9 -4.5 -7.3 -5.9 -3.7