Best TWAS P=3.59e-09 · Best GWAS P=5.72e-10 conditioned to 3.37e-05
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | ARHGEF40 | 0.34 | 0.32 | enet | 17 | 0.31 | 1.5e-17 | -5.7 | -5.5 | 4.6e-08 | 0.06 | 0.02 | 0.98 | TRUE |
| 2 | GTEx | Testis | TOX4 | 0.31 | 0.00 | enet | 24 | 0.04 | 6.8e-03 | -5.6 | -5.9 | 3.6e-09 | -0.49 | 0.03 | 0.62 | TRUE |
| 3 | The Cancer Genome Atlas | Breast Invasive Carcinoma | METTL3 | 0.03 | 0.04 | lasso | 1 | 0.04 | 3.1e-08 | -5.5 | -5.5 | 3.8e-08 | -0.19 | 0.05 | 0.95 | FALSE |
| 4 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | METTL3 | 0.04 | 0.04 | lasso | 2 | 0.04 | 2.5e-05 | -5.6 | -5.6 | 2.0e-08 | -0.20 | 0.04 | 0.92 | FALSE |
| 5 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | METTL3 | 0.17 | 0.03 | lasso | 2 | 0.04 | 1.5e-02 | -5.6 | -5.8 | 9.0e-09 | -0.29 | 0.02 | 0.45 | FALSE |