TWAS hub - ARHGEF40

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.077	0.03	9.4e-03	0.042	0.03	0.07	0.063	0.069	6.0e-06	0.00013	7.1e-09	3.8e-08	8.8e-09
2	GTEx	Artery Aorta	0.343	0.07	4.4e-06	0.321	NA	0.31	NA	0.050	2.9e-18	NA	1.5e-17	NA	9.2e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Pulse rate, automated reading	13.8	44.7	78.1	3.4	8.8
Pulse rate	10.4	17.5	32.5	1.6	5.7
Birth weight	8.1	17.6	23.6	-3.4	-4.9
Eye problems/disorders: None of the above	7.3	8.5	10.3	-3.2	-2.6
Height	6.6	127.0	156.2	-9.9	-12.5
Comparative height size at age 10	6.6	36.1	44.2	-5.3	-6.6
Medication: Lisinopril	6.5	8.4	10.6	2.5	3.3
Depression (self-reported)	6.4	7.6	12.2	-1.7	-3.5
Trunk predicted mass	6.4	36.6	46.6	-5.2	-6.8
Trunk fat-free mass	6.3	36.1	46.1	-5.1	-6.8
Birth weight of first child	6.3	11.5	12.1	-3.3	-3.5
Whole body fat-free mass	5.5	31.3	40.1	-4.8	-6.3
Whole body water mass	5.4	31.0	39.4	-4.7	-6.3
Standing height	5.2	52.0	64.8	-6.3	-8.1
Mouth/teeth dental problems: Bleeding gums	5.2	6.7	7.2	2.5	2.7
Hand grip strength (left)	5.0	13.3	16.3	-3.2	-4.0
Forced expiratory volume in 1-second (FEV1), predicted	4.9	10.2	11.4	-3.0	-3.4
Arm predicted mass (right)	4.7	24.1	29.5	-4.3	-5.4
Hand grip strength (right)	4.5	12.3	14.4	-3.2	-3.8
Leg fat-free mass (left)	4.4	23.1	29.6	-4.1	-5.4
Family relationship satisfaction	4.4	5.4	8.0	1.7	2.8
Basal metabolic rate	4.4	24.4	30.5	-4.3	-5.5
Leg predicted mass (left)	4.3	23.0	29.6	-4.1	-5.4
Leg fat-free mass (right)	4.3	22.7	29.7	-4.0	-5.5
Leg predicted mass (right)	4.3	22.8	29.9	-4.0	-5.5
Pain all over the body in last month	4.2	4.5	7.8	1.1	2.8
Sitting height	4.1	29.1	37.3	-4.6	-6.1
Arm fat-free mass (right)	4.1	21.0	25.7	-4.0	-5.1
Reason for reducing amount of alcohol drunk: Health precaution	3.9	4.6	6.7	-2.6	-1.6
Gout (self-reported)	3.8	5.1	8.4	-2.9	-1.4
Impedance of leg (left)	3.7	17.8	27.0	2.9	5.2
Cholesterol lowering medication	3.7	5.5	6.0	2.5	2.2
Arm predicted mass (left)	3.6	18.3	23.4	-3.6	-4.8
Arm fat-free mass (left)	3.5	17.9	22.3	-3.7	-4.7
High blood pressure (mother)	3.4	4.8	5.1	2.3	2.1
Frequency of tenseness / restlessness in last 2 weeks	3.4	5.3	5.8	2.2	2.4
Had major operations	3.4	4.0	4.9	-2.2	-1.7
Fed-up feelings	3.3	6.0	6.1	2.4	2.5
Exposure to tobacco smoke outside home	3.3	4.5	4.9	-2.2	-2.0
Medication: Allopurinol	3.1	4.2	7.1	-2.7	-1.1
Pack years adult smoking proportion	2.9	4.4	5.4	1.9	2.3
Breast cancer (self-reported)	2.9	3.5	5.5	2.3	1.2
Supplements: Calcium	2.9	3.2	5.0	-1.2	-2.2
Qualifications: A levels/AS levels or equivalent	2.8	6.3	7.0	-2.4	-2.7
Financial situation satisfaction	2.8	3.4	6.8	0.3	2.6
Major Depression (MDD)	2.7	3.3	6.0	-2.5	-0.8
Impedance of leg (right)	2.7	13.2	21.3	2.3	4.6
Frequency of tiredness / lethargy in last 2 weeks	2.7	4.3	4.7	2.2	2.0
Chest pain or discomfort	2.7	3.9	4.8	1.7	2.2
Knee pain experienced in last month	2.7	4.2	4.2	2.1	2.0
Eye problems/disorders: Glaucoma	2.7	3.2	6.4	0.3	2.5
Medication for cholesterol	2.4	3.7	4.5	-2.1	-1.7
Ever taken oral contraceptive pill	2.4	2.7	3.2	-1.8	-1.5
Systolic blood pressure, automated reading	2.3	6.8	9.5	3.1	2.0
Prospective memory result	2.3	2.8	5.4	0.4	2.3
Eye problems/disorders: Cataract	2.3	2.6	5.0	2.2	0.5
Pack years of smoking	2.3	3.4	4.3	1.6	2.1
Age when periods started (menarche)	2.2	5.2	8.3	1.5	2.9
Long-standing illness, disability or infirmity	2.2	3.4	5.3	1.2	2.3
Wears glasses or contact lenses	2.2	2.5	4.5	0.8	2.1
Leg fat percentage (left)	2.2	7.9	14.0	1.3	3.7
Type 2 Diabetes (T2D) (2012)	2.1	2.4	3.7	1.0	1.9
Health satisfaction	2.1	2.8	4.9	0.8	2.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.1	2.5	3.8	1.1	1.9
Hair/balding pattern: Pattern 4	2.0	4.8	5.3	2.3	2.1
Qualifications: O levels/GCSEs or equivalent	2.0	3.2	5.4	-1.0	-2.3
Number of operations (self-reported)	2.0	3.0	4.0	-1.4	-2.0
Ever had prostate specific antigen (PSA) test	2.0	2.3	3.2	-1.1	-1.8
Depression (Nagel 2018)	1.9	2.8	2.8	1.7	1.7
Ever used hormone-replacement therapy (HRT)	1.9	2.4	4.6	2.1	0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	1.9	2.5	3.3	1.3	1.8
Leg fat percentage (right)	1.9	6.8	12.5	1.1	3.5
Qualifications: nursing, teaching	1.9	2.9	4.0	-1.4	-2.0
Alzheimer’s Disease (in mother)	1.8	2.1	3.6	-1.9	-0.8
Coronary Artery Disease (CAD)	1.8	2.1	2.1	1.5	1.5
Seen a psychiatrist for nerves, anxiety, tension or depression	1.8	2.3	3.2	-1.2	-1.8
Overall health rating	1.8	3.9	5.5	1.5	2.3
Impedance of whole body	1.8	9.2	14.1	2.1	3.8
Breast Cancer	1.7	4.1	4.8	-1.8	-2.2
Multivitamins +/- minerals	1.7	2.2	3.7	-0.8	-1.9
Forced vital capacity (FVC), Best measure	1.7	6.3	10.0	-1.6	-3.2
Commuting to job workplace: Walk	1.7	1.9	3.7	0.0	-1.9
Ulcerative Colitis	1.6	2.3	4.3	2.1	0.6
Taking other prescription medications	1.6	2.5	2.7	1.5	1.6
Forced vital capacity (FVC)	1.6	6.1	9.9	-1.5	-3.1
Happiness	1.6	2.0	3.0	1.0	1.7
Illnesses of mother	1.6	2.0	2.6	-1.2	-1.6
Ulcerative Colitis (UC)	1.5	2.7	4.6	2.2	0.9
Diabetes (self-reported)	1.5	2.3	2.9	1.3	1.7
Weight	1.5	7.2	7.6	-2.6	-2.8
Medication: Blood pressure	1.5	2.9	4.1	2.0	1.3
Alcohol drinker status: Previous	1.5	1.7	2.1	-1.2	-1.4
Pulse wave reflection index	1.4	1.7	3.5	0.1	-1.9
Average weekly red wine intake	1.4	2.0	2.2	-1.5	-1.4
Alzheimer’s Disease (including proxy)	1.3	1.9	2.2	-1.2	-1.5
Frequency of depressed mood in last 2 weeks	1.3	1.8	2.3	1.5	1.1
Tinnitus: Yes, but not now, but have in the past	1.3	1.4	2.4	0.5	1.6
Ever highly irritable/argumentative for 2 days	1.3	1.5	2.8	0.5	1.7
Shortness of breath walking on level ground	1.3	1.5	3.1	-0.2	1.7
Diabetes diagnosed by doctor	1.3	2.1	2.7	1.2	1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.3	2.7	2.8	-1.6	-1.7
Fractured/broken bones in last 5 years	1.3	1.7	2.2	-1.5	-1.1
Lung FEV1/FVC ratio	1.2	6.1	9.8	1.5	3.1
Chronotype (morning person)	1.2	2.8	3.8	-2.0	-1.4
Medication: Simvastatin	1.2	1.7	3.0	0.6	1.7
Worrier / anxious feelings	1.2	2.2	3.2	1.8	1.1
Number of children fathered	1.2	1.3	2.5	-1.6	-0.4
Angina (self-reported)	1.2	1.5	2.7	0.6	1.7
Medication: Aspirin	1.2	1.5	1.7	1.1	1.3
Ovarian Cancer	1.1	1.5	1.6	1.3	1.1
Townsend deprivation index at recruitment	1.1	1.6	3.1	-1.8	-0.3
Hair/balding pattern: Pattern 2	1.1	1.4	2.9	-0.2	-1.7
Qualifications: None of the above	1.1	2.4	4.1	0.9	2.0
Body fat percentage	1.1	4.3	7.5	1.0	2.7
Type 2 Diabetes (T2D) (2018)	1.0	1.9	2.6	1.1	1.6
Angina	1.0	1.4	2.5	0.5	1.6
Forced expiratory volume in 1-second (FEV1)	1.0	3.3	4.9	-1.3	-2.2
Forced expiratory volume in 1-second (FEV1), Best measure	1.0	3.1	4.7	-1.2	-2.2
Suffer from ‘nerves’	1.0	1.6	2.3	1.0	1.5
Average weekly champagne plus white wine intake	1.0	1.4	2.8	-0.2	-1.7
Tinnitus: Yes, now most or all of the time	1.0	1.1	2.0	-0.5	-1.4
Unable to work because of sickness or disability	1.0	1.3	1.7	1.3	0.9
Prostate Cancer	0.9	1.3	2.6	1.6	-0.2
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	1.4	1.2	0.8
Heart attack	0.9	1.1	1.7	0.7	1.3
Hair/balding pattern: Pattern 3	0.9	1.4	2.0	0.9	1.4
Noisy workplace	0.9	1.1	2.0	-1.4	-0.3
Neck or shoulder pain in last month	0.9	1.3	1.7	-1.0	-1.3
Back pain experienced in last month	0.9	1.4	2.7	-0.2	-1.6
Osteoporosis (self-reported)	0.9	1.1	1.9	1.4	0.6
Medication: Bendroflumethiazide	0.9	1.4	1.8	1.0	1.4
Irritability	0.9	1.6	2.6	0.8	1.6
Heart attack/myocardial infarction (self-reported)	0.9	1.1	2.0	0.5	1.4
Neuroticism (2016)	0.8	1.1	2.1	1.4	0.5
Illnesses of siblings	0.8	1.1	1.1	-1.1	-1.1
Father’s age at death	0.8	1.0	1.1	1.0	-1.0
Length of working week for main job	0.8	0.8	1.7	-1.3	0.0
Emphysema/chronic bronchitis	0.8	0.9	1.5	0.5	-1.2
Migraine (self-reported)	0.8	1.0	1.8	-0.5	-1.4
Heart disease (mother)	0.8	1.0	2.0	-1.4	0.0
Miserableness	0.8	1.3	2.2	1.5	0.6
Commuting to job workplace: Public transport	0.8	1.0	1.5	1.2	-0.7
Intelligence (Savage-Jansen 2018)	0.7	2.3	4.0	-0.7	-2.0
Blood White Count	0.7	4.9	9.3	0.8	3.0
Sensitivity / hurt feelings	0.7	1.1	1.3	0.9	1.2
Relative age of first facial hair	0.7	1.4	1.4	-1.1	-1.2
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	1.7	0.0	1.3
Medication: Metformin	0.7	1.0	1.9	-0.2	1.4
Trunk fat percentage	0.7	2.7	4.9	0.7	2.2
Serious illness, injury or assault to yourself	0.7	0.8	0.9	0.8	1.0
Medication: Atenolol	0.7	0.9	0.9	0.9	0.9
Number of incorrect matches in round	0.7	1.2	1.8	-1.3	-0.8
Impedance of arm (right)	0.7	3.1	4.4	1.3	2.1
Medication: Cholesterol lowering	0.7	1.1	1.3	-1.2	1.0
Medication: Amlodipine	0.7	1.0	1.9	1.4	0.4
Commuting to job workplace: Car/motor vehicle	0.7	0.9	1.7	0.1	1.3
Arm fat percentage (left)	0.7	2.6	4.4	0.9	2.1
Ever had bowel cancer screening	0.7	0.8	1.4	-0.6	-1.2
Hearing aid user	0.7	0.8	1.5	-1.2	-0.1
Commuting to job workplace: Cycle	0.7	0.9	1.5	1.2	0.5
Verbal and Numeric Reasoning (VNR)	0.6	1.4	1.8	-1.0	-1.3
Primary Biliary Cirrhosis	0.6	0.9	1.3	-0.6	-1.2
Ever had hysterectomy (womb removed)	0.6	0.6	0.7	-0.8	-0.8
Supplements: Zinc	0.6	0.7	1.1	-1.1	-0.5
Had other major operations	0.6	0.7	1.3	-0.3	-1.1
Arm fat percentage (right)	0.6	2.4	4.3	0.8	2.1
Impedance of arm (left)	0.6	2.8	4.0	1.2	2.0
Headache pain in last month	0.6	1.0	1.9	-0.4	-1.4
Worry too long after embarrassment	0.6	1.1	2.0	-1.4	-0.3
Leg pain on walking	0.6	0.7	1.4	-0.0	1.2
Handedness (chirality/laterality): Left-handed	0.6	0.7	1.4	-1.2	-0.2
Friendships satisfaction	0.6	0.7	1.0	1.0	0.6
Myopia	0.6	0.9	1.5	-1.2	-0.6
Irritable Bowel Disease (IBD)	0.5	1.2	2.3	1.5	0.2
Allergy or Eczema	0.5	1.3	2.6	1.6	0.1
Cardiovascular Disease	0.5	1.7	2.5	0.9	1.6
Respiratory disease	0.5	1.1	1.2	-1.1	-1.0
Hayfever, allergic rhinitis or eczema	0.5	1.0	1.9	1.4	0.3
Had menopause	0.5	0.7	1.3	1.1	0.1
Hip circumference	0.5	2.0	2.2	-1.4	-1.5
Falls in the last year	0.5	0.7	1.3	0.4	1.1
Medication: Lansoprazole	0.5	0.6	0.7	0.9	-0.7
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	2.1	-0.1	-1.4
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.1	-0.3	-1.0
Pulse wave peak to peak time	0.5	0.5	0.8	-0.9	-0.5
Medication: Aspirin	0.5	0.6	0.7	0.9	0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.1	1.1	0.1
Illnesses of father: High blood pressure	0.5	0.6	0.6	0.7	0.8
Depressed Affect (Nagel 2018)	0.4	0.8	1.5	1.2	0.3
Age at First Birth	0.4	0.6	0.7	0.9	0.7
Crohns Disease (2012)	0.4	0.6	0.6	0.8	0.8
HDL Cholesterol	0.4	0.7	1.0	-1.0	0.6
Rheumatoid Arthritis	0.4	0.6	1.2	-0.2	1.1
Systolic Blood Pressure	0.4	2.2	3.2	1.8	1.1
Hearing difficulty/problems: Yes	0.4	0.6	1.2	-0.1	-1.1
Medication for hormone replacement therapy	0.4	0.4	0.8	0.1	-0.9
Relative age voice broke	0.4	0.6	1.0	-0.5	-1.0
Bilateral oophorectomy (both ovaries removed)	0.4	0.4	0.9	0.0	-0.9
Waist circumference	0.4	1.5	1.6	-1.2	-1.3
Hearing difficulty/problems with background noise	0.4	0.7	0.9	1.0	0.7
Allergy	0.4	0.9	1.9	-1.4	0.1
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	0.9	-0.2	-1.0
Blood clot in the leg (DVT)	0.4	0.5	0.9	0.9	-0.1
Illnesses of siblings: Diabetes	0.4	0.5	0.9	0.3	1.0
Mineral and other dietary supplements	0.4	0.5	0.9	0.3	1.0
Medication: Atorvastatin	0.4	0.5	0.5	0.7	0.7
Medication: Omeprazole (e.g. Zanprol)	0.4	0.4	0.8	0.9	-0.3
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.1	1.0	-0.0
Schizophrenia vs Biploar Disorder	0.3	0.3	0.7	-0.0	0.8
LDL Cholesterol	0.3	0.5	1.0	-0.1	1.0
Blood Red Count	0.3	3.0	4.1	1.4	-2.0
Heel T-Score	0.3	2.5	2.8	1.7	1.5
Waist Hip Ratio (WHR)	0.3	1.3	1.5	-1.2	-1.0
Hair Pigment	0.3	9.0	10.2	-2.8	-3.2
Number of treatments/medications taken	0.3	0.5	0.7	0.8	-0.5
Current tobacco smoking	0.3	0.5	0.6	0.7	0.7
High blood pressure	0.3	0.7	1.0	1.0	0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.6	0.9	-1.0	-0.5
Mouth/teeth dental problems	0.3	0.5	0.9	-0.9	-0.2
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	0.5	0.7	-0.6
Mouth/teeth dental problems: Dentures	0.3	0.4	0.6	0.6	-0.7
Lung cancer (father)	0.3	0.3	0.4	0.6	0.5
Pulse wave Arterial Stiffness index	0.3	0.3	0.6	0.8	0.2
Exposure to tobacco smoke at home	0.3	0.3	0.6	0.0	-0.8
Tense / ‘highly strung’	0.3	0.6	1.0	-0.3	1.0
Glaucoma (self-reported)	0.3	0.4	0.6	-0.4	0.8
Mouth/teeth dental problems: Loose teeth	0.3	0.3	0.6	-0.8	-0.2
Medication: Omeprazole	0.3	0.4	0.4	0.6	-0.6
Alcohol intake frequency.	0.3	0.6	1.2	0.0	1.1
Hypertension (Self-reported)	0.3	0.9	1.2	1.1	0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.4	0.6	0.4	0.8
Illnesses of father: None of the above (group 1)	0.3	0.4	0.5	-0.7	-0.6
Mother’s age at death	0.3	0.4	0.8	-0.0	-0.9
Supplements: Fish oil (including cod liver oil)	0.3	0.3	0.7	-0.0	-0.8
Heart disease (siblings)	0.3	0.4	0.5	0.5	-0.7
Neuroticism (Nagel 2018)	0.2	0.5	0.7	0.8	0.4
Alzheimer’s Disease (in father)	0.2	0.2	0.5	0.0	-0.7
Fasting Glucose	0.2	0.3	0.5	-0.0	0.7
Schizophrenia (2014)	0.2	0.4	0.7	0.3	0.9
Blood Platelet Count	0.2	2.6	5.2	-0.3	2.3
Lung FVC	0.2	0.9	1.5	0.5	-1.2
Average weekly spirits intake	0.2	0.2	0.3	-0.4	-0.5
Vitamin and mineral supplements	0.2	0.3	0.5	0.1	0.7
Diabetes (mother)	0.2	0.3	0.6	0.8	0.1
Average weekly fortified wine intake	0.2	0.2	0.4	-0.6	-0.0
Maternal smoking around birth	0.2	0.3	0.7	-0.8	0.1
Stomach or abdominal pain in last month	0.2	0.3	0.5	0.2	-0.7
Supplements: Glucosamine	0.2	0.3	0.4	0.3	-0.7
Medication: Levothyroxine sodium	0.2	0.4	0.4	0.5	-0.7
Nervous feelings	0.2	0.3	0.5	-0.7	-0.4
Financial difficulties in last 2 years	0.2	0.3	0.6	0.8	0.2
Fluid intelligence score	0.2	0.4	0.5	-0.5	-0.7
Asthma	0.2	0.4	0.7	-0.3	-0.8
Breastfed as a baby	0.2	0.3	0.3	0.5	-0.5
Peak expiratory flow (PEF)	0.2	0.4	0.6	0.4	0.8
Comparative body size at age 10	0.2	0.4	0.8	0.9	-0.1
Number of full brothers	0.2	0.3	0.5	-0.7	-0.3
Medication for pain relief, constipation, heartburn	0.2	0.4	0.7	-0.9	-0.3
Medication: Ibuprofen	0.2	0.2	0.4	0.3	-0.6
Mean time to correctly identify matches	0.2	0.3	0.4	-0.5	-0.6
Number of full sisters	0.2	0.2	0.3	-0.3	0.5
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	0.5	-0.7	0.1
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	0.5	-0.7	-0.3
Supplements: Vitamin C	0.2	0.3	0.3	0.5	-0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.3	0.5	0.7	0.1
Illnesses of father: Heart disease	0.2	0.3	0.3	-0.5	0.5
Asthma (self-reported)	0.2	0.4	0.7	-0.3	-0.8
Medication: Gliclazide	0.2	0.2	0.5	-0.0	0.7
Guilty feelings	0.2	0.4	0.4	-0.6	-0.6
Alcohol drinker status: Never	0.2	0.3	0.6	-0.0	0.7
Risk taking	0.2	0.3	0.4	0.3	0.7
Diastolic blood pressure, automated reading	0.2	0.5	0.6	0.7	0.7
Vascular/heart problems diagnosed by doctor	0.2	0.6	0.9	-0.9	-0.5
Bipolar Disorder (2018)	0.1	0.1	0.1	0.3	-0.2
Schizophrenia (2018)	0.1	0.2	0.4	-0.6	0.1
Worry (Nagel 2018)	0.1	0.2	0.2	0.5	0.4
Crohns Disease (2017)	0.1	0.2	0.4	0.6	-0.1
Reaction Time	0.1	0.1	0.2	-0.1	-0.5
Body Mass Index (BMI) (2010)	0.1	0.2	0.3	-0.0	0.6
Mean Putamen Volume	0.1	0.1	0.2	0.0	-0.4
HbA1C	0.1	0.2	0.3	0.5	0.2
Lupus	0.1	0.2	0.2	0.5	-0.4
Smoking Status	0.1	0.3	0.5	0.1	0.7
Hypothyroidism (self reported)	0.1	0.3	0.5	-0.4	-0.7
Neuroticism	0.1	0.3	0.5	0.1	0.7
Tanning	0.1	0.6	0.9	0.6	-1.0
Severe depression (siblings)	0.1	0.1	0.2	0.2	0.4
Qualifications: CSEs or equivalent	0.1	0.1	0.2	-0.3	-0.4
Body mass index (BMI)	0.1	0.4	0.7	0.2	0.8
Trunk fat mass	0.1	0.2	0.5	-0.7	0.1
Alcohol usually taken with meals	0.1	0.2	0.3	0.4	0.5
Neuroticism score	0.1	0.3	0.4	0.4	0.6
Alcohol intake versus 10 years previously	0.1	0.2	0.4	0.1	0.6
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.2	0.5	-0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	0.4	0.2	-0.6
Loud music exposure frequency	0.1	0.1	0.1	0.4	0.3
Medication: Paracetamol	0.1	0.2	0.3	0.5	-0.1
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.3	0.4	-0.5
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.1	-0.3	-0.2
Wheeze or whistling in the chest in last year	0.1	0.1	0.2	0.5	0.1
Age at first live birth	0.1	0.2	0.4	-0.2	-0.6
Qualifications: College or University degree	0.1	0.3	0.5	-0.4	-0.7
Medication: Seretide 50 evohaler	0.1	0.1	0.1	0.3	-0.2
Whole body fat mass	0.1	0.3	0.6	-0.8	0.0
Leg fat mass (right)	0.1	0.4	0.8	-0.3	0.9
Age at last live birth	0.1	0.1	0.2	-0.1	-0.5
Smoking status: Previous	0.1	0.2	0.2	0.5	0.3
Mood swings	0.1	0.1	0.2	-0.5	-0.2
Loneliness, isolation	0.1	0.1	0.2	-0.1	-0.4
Mouth/teeth dental problems: Mouth ulcers	0.1	0.1	0.1	0.3	-0.3
Number of self-reported non-cancer illnesses	0.1	0.2	0.4	-0.3	-0.6
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.2	-0.4	-0.1
Medication: Paracetamol	0.1	0.1	0.2	0.5	-0.1
Age started oral contraceptive pill	0.1	0.1	0.2	-0.1	-0.4
Pain experienced in last month	0.1	0.2	0.4	-0.6	0.0
Basal cell carcinoma (self-reported)	0.1	0.1	0.1	-0.4	0.1
Leg fat mass (left)	0.1	0.6	1.1	-0.2	1.1
Bipolar Disorder or Schizophrenia	0.0	0.0	0.1	-0.3	-0.1
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0
Triglycerides	0.0	0.0	0.0	-0.0	0.1
Blood Eosinophil Count	0.0	0.2	0.2	-0.4	-0.5
BMI	0.0	0.2	0.3	-0.0	0.6
Medication: Co-codamol	0.0	0.0	0.0	-0.1	-0.2
Diabetes (father)	0.0	0.0	0.1	0.3	-0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.0	0.1	0.2	-0.4	0.1
Diverticular disease/diverticulitis (self-reported)	0.0	0.0	0.1	-0.0	0.2
Chronic bronchitis/emphysema (father)	0.0	0.0	0.0	-0.1	0.1
Past tobacco smoking	0.0	0.0	0.0	0.2	0.2
Ever unenthusiastic/disinterested for a whole week	0.0	0.1	0.1	-0.3	-0.0
Medication: Ramipril	0.0	0.0	0.0	-0.2	0.2
Time employed in main current job	0.0	0.1	0.1	-0.3	0.1
Number of live births	0.0	0.1	0.1	0.2	-0.3
Arm fat mass (right)	0.0	0.1	0.3	-0.5	-0.1
High blood pressure (siblings)	0.0	0.0	0.0	-0.1	0.1
Medication: Blood pressure	0.0	0.1	0.1	0.2	0.3
Osteoarthritis (self-reported)	0.0	0.0	0.1	0.2	0.0
Smoking status: Current	0.0	0.0	0.1	-0.1	0.3
Arm fat mass (left)	0.0	0.1	0.3	-0.5	-0.1
High cholesterol (Self-reported)	0.0	0.0	0.1	-0.1	0.3
Ever smoked	0.0	0.0	0.1	-0.0	-0.3
Average weekly beer plus cider intake	0.0	0.0	0.0	0.0	0.2
Ever depressed for a whole week	0.0	0.0	0.0	-0.2	0.2

Hub : Genes

ARHGEF40

Models

Trait associations