Hub : Genes

TOX4

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adipose Visceral Omentum 0.2290 0.0640 5.1e-04 0.019 NA -0.005 NA 0.011 3.5e-02 NA 7.7e-01 NA 8.5e-02
2 GTEx Cells Transformed fibroblasts 0.1890 0.0530 2.8e-04 0.056 NA 0.038 NA 0.054 5.1e-05 NA 7.9e-04 NA 6.6e-05
3 GTEx Esophagus Muscularis 0.2200 0.0550 6.3e-05 0.024 NA 0.047 NA 0.042 1.2e-02 NA 8.0e-04 NA 1.4e-03
4 GTEx Lung 0.1791 0.0499 1.0e-04 0.072 NA 0.035 NA 0.053 3.5e-06 NA 1.1e-03 NA 6.9e-05
5 GTEx Nerve Tibial 0.1369 0.0479 3.0e-03 0.027 NA 0.012 NA 0.049 4.9e-03 NA 4.3e-02 NA 2.2e-04
6 GTEx Testis 0.3140 0.0990 6.3e-03 -0.001 NA 0.040 NA 0.029 3.6e-01 NA 6.8e-03 NA 1.9e-02
7 METSIM Adipose 0.0399 0.0155 1.8e-03 0.025 0.019 0.030 0.026 0.033 1.0e-04 5.5e-04 1.9e-05 7.8e-05 8.8e-06
8 YFS Blood 0.1158 0.0179 0.0e+00 0.093 0.094 0.123 0.116 0.122 9.1e-29 4.2e-29 4.9e-38 8.3e-36 7.0e-38
9 TCGA Breast Invasive Carcinoma 0.0202 0.0099 4.8e-04 0.022 0.014 0.013 NA 0.015 1.6e-05 5.4e-04 6.9e-04 NA 3.8e-04
10 TCGA Colon Adenocarcinoma 0.0720 0.0370 3.1e-03 0.034 0.031 0.045 NA 0.014 4.5e-03 6.2e-03 1.3e-03 NA 4.8e-02
11 TCGA Kidney Renal Clear Cell Carcinoma 0.0548 0.0228 6.8e-05 0.033 0.038 0.027 NA 0.029 1.2e-04 3.9e-05 4.4e-04 NA 2.6e-04
12 TCGA Brain Lower Grade Glioma 0.1540 0.0459 1.9e-12 0.043 0.107 0.096 NA 0.092 1.1e-05 3.7e-12 4.9e-11 NA 1.2e-10
13 TCGA Prostate Adenocarcinoma 0.0785 0.0287 2.5e-08 0.108 0.073 0.087 NA 0.105 2.1e-11 4.0e-08 2.0e-09 NA 4.9e-11
14 TCGA Rectum Adenocarcinoma 0.2180 0.1070 7.9e-03 0.008 0.045 0.026 NA 0.067 2.0e-01 3.2e-02 8.1e-02 NA 1.1e-02
15 TCGA Thyroid Carcinoma 0.0970 0.0360 5.4e-09 0.078 0.062 0.085 NA 0.038 4.6e-08 1.2e-06 1.1e-08 NA 1.4e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bipolar Disorder (2018) 1.4 2.2 6.5 -1.0 -0.5 -1.2 -1.8 -1.5 -0.3 -2.1 1.1 0.0 -1.3 -2.0 -2.5 -1.7 0.0 -2.0
Bipolar Disorder or Schizophrenia 0.3 0.6 1.6 1.3 1.1 0.6 -0.7 0.6 0.6 -0.5 0.2 0.0 -0.7 -1.1 -0.9 -0.9 -0.2 -1.1
Depressed Affect (Nagel 2018) 0.7 1.5 5.3 -0.7 1.9 0.3 -0.9 0.9 2.3 -0.4 -0.1 -2.2 -0.8 -1.7 -1.0 -0.7 0.0 -1.3
Depression (Nagel 2018) 0.5 0.8 2.9 -0.6 1.4 0.0 -0.7 1.5 1.5 0.4 0.5 -1.7 0.3 -0.4 0.3 -0.8 0.0 -0.6
Intelligence (Savage-Jansen 2018) 0.1 0.4 1.0 -0.5 -0.1 0.0 -0.8 -0.8 -0.5 -0.9 0.6 -1.0 -0.2 -0.3 -0.6 -0.7 0.0 -1.0
Neuroticism (Nagel 2018) 0.6 1.5 4.6 -0.8 0.9 -0.2 -1.1 0.5 1.8 -0.7 0.3 -2.2 -1.2 -2.0 -1.7 -0.8 0.0 -1.4
Schizophrenia (2018) 0.6 1.3 5.9 2.4 1.9 1.7 0.6 1.9 1.1 1.1 -0.6 0.0 0.7 0.3 0.7 0.2 0.0 0.3
Schizophrenia vs Biploar Disorder 1.9 2.5 9.3 3.0 1.7 1.5 1.9 1.9 1.0 1.9 -1.9 0.0 0.0 1.4 1.6 1.8 0.0 0.0
Worry (Nagel 2018) 0.4 0.9 4.0 0.3 0.5 -0.5 -0.5 -0.0 1.5 -0.7 -0.5 -1.0 -0.6 -2.0 -1.8 -0.1 0.0 -0.8
Alzheimer’s Disease (in mother) 1.5 1.8 5.0 1.1 1.6 1.6 0.8 1.8 2.2 1.4 -1.2 0.1 1.2 1.1 1.4 1.1 0.9 0.9
Alzheimer’s Disease (in father) 2.5 2.7 5.0 0.6 0.4 1.5 2.0 1.0 1.2 1.9 -1.5 1.9 1.3 1.8 2.2 1.9 1.6 2.2
Alzheimer’s Disease (including proxy) 3.4 4.9 8.7 1.1 1.8 2.7 2.6 2.3 3.0 2.7 -2.2 1.5 1.3 1.9 2.3 2.6 2.0 2.3
Crohns Disease (2017) 0.5 1.1 4.0 0.8 -1.5 -0.3 0.4 -0.7 -1.1 0.6 0.5 2.0 -0.9 1.7 1.0 0.2 0.0 1.4
Irritable Bowel Disease (IBD) 0.5 1.3 3.6 0.7 -1.6 0.3 0.6 -0.7 -1.5 0.7 0.7 1.9 -1.3 1.8 1.3 0.2 0.0 1.4
Ulcerative Colitis (UC) 0.4 0.8 2.2 0.5 -1.2 0.6 0.6 -0.3 -1.2 0.7 0.3 1.3 -1.3 1.5 1.1 0.4 0.0 0.9
Major Depression (MDD) 0.4 0.5 1.6 -0.4 0.3 0.4 -0.2 -1.3 0.1 -0.7 -1.0 0.0 1.1 -0.5 -0.9 0.5 0.9 -0.0
Reaction Time 1.8 3.4 7.2 0.5 0.4 2.2 2.6 1.0 -0.3 2.2 -1.4 2.0 2.0 2.7 2.1 2.1 1.0 2.5
Verbal and Numeric Reasoning (VNR) 0.4 1.0 2.4 -1.3 1.1 1.2 0.8 1.1 0.7 0.8 -1.1 -0.1 1.6 1.2 1.2 1.0 0.7 0.7
Breast Cancer 0.6 1.4 5.2 -0.1 2.0 0.7 0.1 2.3 2.3 1.3 -0.4 -0.6 0.9 0.7 1.3 0.4 -0.1 0.4
Ovarian Cancer 1.3 1.8 5.2 -0.9 1.4 -0.9 -1.6 0.9 1.5 -0.5 0.9 -2.3 -1.3 -0.7 -0.5 -1.5 -1.7 -1.9
Prostate Cancer 0.7 0.9 3.3 0.3 0.5 -1.4 -0.4 -0.0 0.4 -1.1 -0.1 -1.6 0.6 -1.0 -1.8 -0.8 0.1 -1.6
Age at First Birth 1.4 2.0 5.5 -1.6 -0.4 -2.3 -0.6 -1.6 -0.9 -2.2 -0.8 -0.9 0.7 -1.9 -1.9 -0.2 1.2 -1.6
Bipolar Disorder (2011) 0.2 0.2 0.8 0.6 0.9 0.9 0.2 0.7 0.0 0.6 -0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 1.0 1.3 4.8 -0.7 -0.0 0.5 -1.6 0.3 -0.0 -0.6 2.1 0.0 -1.3 -0.9 -0.5 -1.8 -2.2 -1.1
Coronary Artery Disease (CAD) 0.7 0.9 3.2 -1.8 0.3 -0.4 1.5 -0.5 -0.4 0.8 -1.4 0.0 0.0 1.3 0.6 1.6 0.0 0.0
Crohns Disease (2012) 0.5 0.8 3.7 0.1 -1.2 -1.3 -0.7 -1.9 -1.2 -1.2 0.3 0.0 -0.5 -0.4 -1.2 -0.6 0.3 -0.3
Mean Putamen Volume 0.6 0.7 6.4 -2.5 -0.1 -0.7 0.5 -0.2 0.5 -0.0 -0.7 0.2 0.7 -0.1 0.4 0.7 0.5 0.6
Fasting Glucose 1.5 1.8 3.9 -0.4 -0.1 -0.9 -1.9 -0.1 0.4 -1.5 1.4 -2.0 -0.7 -1.9 -1.0 -1.9 -1.5 -1.6
HbA1C 3.2 3.5 5.0 -2.1 -1.3 -2.2 -2.0 -1.6 -0.4 -2.2 1.9 -1.8 -2.0 -1.9 -1.8 -2.2 -2.0 -2.1
HDL Cholesterol 0.7 1.1 2.7 -0.3 0.5 1.3 1.4 1.1 1.0 1.3 -0.9 0.0 1.2 1.3 1.1 1.1 0.5 1.6
LDL Cholesterol 0.3 0.5 1.2 -0.2 -0.8 -0.8 -0.6 -1.1 -0.8 -0.7 0.6 0.0 -1.1 -0.4 -0.5 -0.5 -0.7 -0.5
Lupus 1.4 2.1 5.1 -1.9 -0.6 -1.1 -1.5 -1.7 0.9 -1.9 0.7 -1.2 -0.8 -2.3 -1.9 -1.1 -0.2 -1.9
Neuroticism (2016) 1.0 1.4 3.3 0.6 0.7 -0.3 -1.4 0.0 0.8 -1.0 0.6 -1.7 -1.5 -1.7 -1.8 -1.2 -1.1 -1.5
Primary Biliary Cirrhosis 1.0 1.4 7.5 -1.5 -1.5 -0.9 0.1 -2.0 -2.7 -0.9 -0.2 0.0 -1.3 -0.1 -0.9 0.2 0.5 0.4
Rheumatoid Arthritis 0.2 0.2 0.7 -0.8 -0.8 -0.5 0.0 -0.3 -0.3 0.1 0.4 0.0 -0.8 -0.0 -0.1 -0.1 -0.7 0.4
Schizophrenia (2014) 0.6 1.3 7.2 2.7 1.6 1.5 0.5 1.8 1.2 1.1 -0.5 0.0 0.6 0.7 0.8 0.1 0.0 0.3
Triglycerides 0.5 0.9 1.9 -0.8 -1.3 -0.3 -1.0 -1.4 -1.2 -0.9 1.3 0.0 -0.7 -0.2 -0.0 -1.0 -1.3 -0.6
Type 2 Diabetes (T2D) (2012) 0.9 1.1 3.3 -0.0 -1.7 -1.5 -0.6 -1.8 -1.8 -1.1 0.6 0.0 -0.4 -0.6 -1.1 -0.7 0.0 -0.4
Ulcerative Colitis 0.4 0.5 4.6 0.6 -1.2 0.1 0.0 -0.8 -2.1 -0.2 0.4 0.0 0.1 0.8 -0.2 -0.0 0.1 0.2
Blood Eosinophil Count 0.4 3.2 7.6 2.8 2.2 2.1 2.1 2.4 1.0 2.5 -1.2 0.3 0.5 1.9 2.0 1.5 -0.4 1.5
Blood Platelet Count 1.3 14.7 24.6 3.1 3.4 3.5 4.7 4.5 2.2 5.0 -3.5 2.2 3.9 4.9 4.4 4.0 2.9 3.9
Blood Red Count 0.3 3.3 12.8 1.1 -2.3 1.2 1.2 -0.6 -2.1 1.8 0.7 3.6 -1.6 2.2 2.0 1.0 -0.6 2.7
Blood White Count 0.2 1.1 5.8 2.4 0.4 0.5 1.4 1.0 0.1 1.4 -0.2 0.8 0.3 1.2 1.2 0.7 -0.5 1.2
Heel T-Score 0.5 3.9 15.0 0.6 3.9 1.8 1.2 2.9 3.6 1.1 -2.3 -1.4 1.8 -0.4 0.4 1.3 1.8 0.1
BMI 0.6 3.3 13.0 -0.4 -2.7 0.4 -0.4 -1.3 -3.6 0.6 2.5 2.1 -1.7 1.5 1.3 -0.9 -2.6 1.1
Height 1.0 19.0 92.5 -1.1 -8.3 -1.6 -1.7 -5.8 -9.6 -0.4 4.1 5.3 -1.8 3.3 1.4 -1.0 -3.9 2.2
Waist Hip Ratio (WHR) 0.8 3.4 10.1 0.6 0.4 1.9 1.5 1.7 0.1 2.6 -0.5 2.3 0.9 3.2 3.1 1.5 0.7 2.5
Systolic Blood Pressure 0.6 3.0 6.6 -0.0 2.0 0.5 2.1 1.8 2.1 1.5 -2.2 0.7 2.6 1.1 1.4 2.0 2.2 1.3
Smoking Status 0.8 1.9 4.5 1.5 -1.8 0.7 0.1 0.2 0.1 1.5 2.1 1.8 -0.0 2.1 1.9 -0.4 -1.7 1.3
Allergy or Eczema 0.1 0.1 1.0 0.3 0.6 -0.3 0.0 -0.0 1.0 -0.2 -0.3 -0.3 -0.0 -0.4 0.1 -0.0 -0.4 -0.2
Cardiovascular Disease 0.2 0.6 2.0 0.1 1.3 0.8 -0.0 1.2 0.8 0.7 -0.5 -0.4 1.4 0.9 0.6 0.2 0.1 0.2
Hypothyroidism (self reported) 0.7 1.7 4.4 -0.6 -1.6 -0.9 -0.9 -1.8 -2.1 -0.9 1.6 0.4 -2.0 -0.2 -0.8 -1.2 -2.0 -0.4
Respiratory disease 1.4 3.1 6.9 2.0 0.4 0.2 -2.0 0.3 -0.3 -1.3 2.4 -2.6 -1.6 -1.4 -0.8 -2.6 -2.5 -2.2
Type 2 Diabetes (T2D) (2018) 0.5 0.9 4.0 0.2 -1.3 -1.4 -0.6 -1.3 -2.0 -0.8 0.5 0.1 -0.1 -0.2 -1.2 -0.6 -0.4 -0.5
Lung FEV1/FVC ratio 0.3 1.3 4.3 -0.4 -1.0 1.3 1.0 0.4 -0.1 1.6 0.1 2.1 -0.0 2.0 1.4 0.8 0.2 1.7
Lung FVC 0.3 1.8 5.6 1.4 2.1 1.2 1.3 2.4 1.7 1.6 -0.6 -0.4 0.9 1.1 1.4 0.7 -0.3 0.8
Neuroticism 0.6 1.5 3.7 -0.3 0.9 0.4 -1.4 1.0 1.3 -0.3 1.2 -1.9 -1.6 -1.4 -1.1 -1.4 -1.6 -1.2
Chronotype (morning person) 0.2 0.4 1.5 -0.3 -0.6 -0.7 -0.4 0.1 -0.5 0.4 0.9 0.3 -1.0 0.6 1.2 -0.4 -0.9 0.2
Hair Pigment 0.0 0.8 4.5 0.8 0.7 -1.0 0.5 -0.3 -0.1 -0.2 -1.7 0.4 0.3 -0.7 -1.0 1.0 2.1 -0.1
Tanning 0.3 4.0 9.1 1.5 -1.8 -2.1 -2.6 -1.6 -1.0 -1.9 2.8 -1.2 -2.1 -1.3 -1.0 -2.7 -3.0 -1.9
Hand grip strength (left) 0.8 2.1 7.3 0.6 -2.4 -1.8 -1.1 -1.8 -2.7 -1.0 1.8 0.9 -1.4 -0.0 -0.1 -1.2 -1.5 -0.2
Number of treatments/medications taken 1.4 2.6 6.0 -0.2 -1.6 -1.6 -2.3 -1.1 -1.1 -1.3 2.4 -1.0 -1.4 -1.3 -2.0 -1.9 -2.2 -1.2
Average weekly spirits intake 0.6 0.7 1.7 -0.0 -0.6 -0.0 -1.3 -0.4 -1.3 -0.9 0.9 -0.5 -0.6 -1.0 -1.1 -1.0 0.1 -0.9
Sensitivity / hurt feelings 0.7 1.2 3.1 -1.1 0.2 -0.4 -1.4 0.7 0.7 -0.5 1.4 -1.8 -0.9 -1.4 -1.1 -1.4 -1.1 -1.3
Frequency of depressed mood in last 2 weeks 0.6 0.8 2.9 -0.3 1.4 0.6 0.5 1.6 1.7 0.8 -0.3 -0.7 1.5 0.6 0.5 0.1 -0.4 0.2
Hearing difficulty/problems: Yes 0.2 0.3 2.0 -1.4 -0.1 -1.0 0.5 -0.5 -0.8 -0.1 -0.4 0.5 0.3 -0.1 -0.2 0.3 0.1 0.6
Relative age of first facial hair 0.5 0.9 3.0 -0.2 0.5 -0.0 1.5 0.6 -0.5 1.1 -0.9 0.9 0.8 1.3 0.9 1.2 0.5 1.7
Other serious medical condition/disability diagnosed by doctor 0.5 0.6 1.7 0.0 -0.2 1.2 0.6 -0.8 -1.3 0.0 -1.1 0.7 0.5 0.3 -0.5 1.1 1.1 0.5
Ever used hormone-replacement therapy (HRT) 1.2 1.5 3.6 0.2 0.4 1.9 1.5 1.0 1.3 1.6 -0.8 1.1 0.0 1.5 1.7 1.2 0.4 1.5
Ever had hysterectomy (womb removed) 1.3 1.5 4.1 1.1 0.5 0.8 1.6 1.1 -0.3 1.6 -0.7 1.2 0.2 1.8 2.0 1.1 0.1 1.7
Systolic blood pressure, automated reading 0.3 1.0 3.2 -0.5 1.2 1.2 1.2 0.9 1.8 0.9 -1.1 0.4 0.6 0.5 0.9 1.0 1.0 0.6
Eye problems/disorders: Diabetes related eye disease 2.4 2.6 4.9 -0.7 0.2 -0.4 1.7 0.4 -1.8 1.7 -1.8 2.1 2.2 2.1 1.0 2.1 1.7 2.1
Angina 0.1 0.2 1.0 1.0 0.3 0.2 -0.6 0.3 -0.1 -0.1 0.2 -0.7 0.2 0.1 -0.1 -0.4 -0.3 -0.6
Medication for hormone replacement therapy 0.5 0.5 1.3 0.9 -0.1 0.7 0.9 0.2 -0.7 0.9 -0.2 0.8 0.4 1.1 0.7 0.7 -0.2 1.1
Vitamin and mineral supplements 0.4 0.5 4.7 -2.2 0.5 -1.0 -0.0 0.0 -0.3 -0.3 -0.3 -0.4 0.8 0.1 -0.2 -0.0 0.1 -0.0
Supplements: Zinc 0.4 0.4 1.7 -1.2 -0.5 -1.3 -0.1 -0.7 0.6 -0.8 -0.2 0.2 -0.6 -0.7 -0.4 -0.2 0.5 -0.1
Medication: Co-codamol 0.3 0.4 2.3 -0.2 -1.5 -0.1 0.1 -0.5 -0.7 0.4 0.7 0.8 0.1 0.7 0.2 0.1 -0.7 0.5
Medication: Metformin 1.0 1.4 9.2 1.0 -1.9 -0.3 -0.0 -1.1 -3.0 0.2 0.9 1.2 -0.7 1.0 -0.1 -0.2 -1.0 0.6
Diabetes (father) 0.2 0.3 0.8 0.9 -0.9 0.1 -0.2 -0.4 -0.6 0.2 0.2 0.9 0.5 0.8 0.2 0.1 -0.1 0.5
Diabetes (mother) 0.8 1.0 2.9 0.5 -1.1 -0.7 1.0 -1.4 -1.7 -0.2 -0.9 1.3 1.1 0.3 -0.2 1.0 1.2 0.8
Severe depression (siblings) 0.5 0.6 2.2 0.0 -0.7 0.2 -0.7 0.1 -0.7 0.1 1.5 0.1 -1.5 0.1 0.0 -0.8 -1.4 0.2
Pack years adult smoking proportion 0.3 0.4 2.1 0.1 -0.5 0.6 0.3 0.5 0.1 0.8 0.2 0.8 1.4 1.0 0.6 0.4 0.1 0.8
Impedance of leg (right) 0.3 1.5 5.7 1.7 1.2 0.5 0.8 0.5 1.9 -0.2 -1.7 -0.2 1.7 -0.5 -0.5 1.0 2.4 -0.1
Leg fat-free mass (left) 1.3 7.1 35.9 -0.8 -4.9 0.1 -0.3 -2.6 -6.0 0.7 2.4 3.7 -0.9 2.8 1.3 -0.2 -2.4 2.0
Trunk fat percentage 1.3 5.4 20.2 0.1 -3.2 2.1 1.6 -1.0 -3.0 2.0 0.1 4.5 1.0 3.1 2.0 1.7 0.4 3.4
Hand grip strength (right) 0.7 2.0 6.6 0.4 -2.6 -1.4 -1.2 -1.8 -2.2 -1.2 1.9 0.5 -1.1 -0.2 0.1 -1.4 -1.4 -0.5
Townsend deprivation index at recruitment 0.2 0.3 1.2 -0.4 0.8 -0.0 0.3 0.5 0.2 0.4 -0.3 -0.1 1.1 0.9 0.5 0.3 -0.2 0.4
Current tobacco smoking 0.6 1.0 2.6 1.3 -0.3 1.6 0.3 1.1 1.2 1.0 0.9 0.9 0.8 1.4 1.2 -0.2 -0.3 0.7
Average weekly fortified wine intake 0.8 0.9 4.7 2.2 0.6 2.1 0.5 0.9 1.3 0.5 0.2 -0.5 0.7 0.1 0.6 -0.0 0.2 0.0
Maternal smoking around birth 1.3 1.9 6.6 0.7 -2.0 1.2 0.8 -0.3 -1.6 1.2 0.5 2.6 0.8 1.8 1.1 0.8 -0.3 2.2
Fed-up feelings 0.2 0.4 1.3 -1.1 0.8 0.2 -0.2 0.5 0.7 -0.0 0.0 -1.0 0.2 -0.5 -1.1 -0.3 -0.7 -0.7
Frequency of unenthusiasm / disinterest in last 2 weeks 0.5 0.7 3.0 0.1 1.7 0.4 0.3 1.6 1.4 0.7 -0.5 -0.9 1.0 0.2 0.5 0.1 -0.4 -0.1
Relative age voice broke 0.2 0.3 1.4 -0.1 -0.8 -1.1 -0.1 -0.8 -1.2 -0.4 0.5 0.2 0.3 0.0 -0.5 -0.2 -0.2 0.3
Taking other prescription medications 0.1 0.2 0.6 0.7 -0.2 0.2 0.3 0.5 -0.3 0.8 0.2 0.6 0.1 0.6 -0.0 0.4 0.1 0.7
Age when periods started (menarche) 0.2 0.5 2.5 -0.2 -1.5 -0.6 -0.0 -1.6 -0.8 -0.8 0.1 0.7 -0.3 -0.4 -0.2 0.1 0.3 0.4
Bilateral oophorectomy (both ovaries removed) 3.9 4.5 12.5 2.4 -1.7 0.9 2.4 -0.1 -1.6 1.9 -0.7 3.5 0.5 3.3 2.8 1.8 0.6 3.3
Heel bone mineral density (BMD) T-score, automated (left) 1.0 2.2 5.2 -1.5 2.2 2.2 0.8 2.0 2.3 1.3 -1.3 -0.1 1.8 0.5 0.7 1.1 1.4 0.4
Tinnitus: Yes, but not now, but have in the past 0.1 0.1 0.2 -0.1 -0.3 -0.4 -0.3 -0.3 -0.4 -0.3 0.2 -0.2 -0.0 -0.4 0.1 -0.3 0.0 -0.4
Qualifications: CSEs or equivalent 1.4 1.8 3.2 1.0 -1.8 -1.7 -1.6 -1.6 -1.3 -1.2 1.8 0.3 -1.7 -0.8 -0.9 -1.4 -1.1 -0.9
Serious illness, injury or assault to yourself 0.6 0.7 3.2 0.2 -1.6 -0.6 -0.7 -1.3 -1.8 -0.5 0.8 0.2 -0.4 0.1 -0.5 -0.4 -0.6 -0.4
High blood pressure 0.1 0.2 0.7 0.2 0.4 0.7 -0.5 0.3 0.2 -0.1 0.5 -0.8 -0.2 -0.1 -0.2 -0.5 -0.5 -0.7
Hayfever, allergic rhinitis or eczema 0.0 0.1 0.4 0.4 -0.2 -0.6 0.2 -0.3 0.4 -0.1 -0.1 0.1 -0.6 -0.2 0.3 -0.0 -0.3 -0.1
Multivitamins +/- minerals 0.6 0.8 1.6 0.9 -1.2 -0.1 -1.1 -0.8 -0.2 -0.9 1.3 -0.1 -0.8 -1.0 -0.9 -1.0 -0.9 -0.8
Stomach or abdominal pain in last month 1.3 1.6 4.0 0.7 -1.4 -1.5 -1.4 -1.0 -1.6 -1.1 1.7 -0.7 -0.4 -0.4 -1.2 -1.5 -2.0 -1.1
Supplements: Glucosamine 0.1 0.2 0.8 -0.3 -0.4 -0.2 0.3 -0.2 -0.4 0.1 -0.6 0.5 0.4 0.2 -0.3 0.6 0.9 0.2
Diverticular disease/diverticulitis (self-reported) 0.3 0.4 1.6 0.0 0.6 1.0 0.3 0.4 1.1 0.3 -0.2 -0.2 1.2 0.5 0.8 0.3 -0.1 0.2
Medication: Atenolol 0.3 0.3 1.1 -1.1 -0.6 0.9 -0.1 -0.1 -0.5 0.4 0.4 0.7 0.9 0.6 0.5 0.0 -0.0 0.3
Medication: Levothyroxine sodium 0.5 0.9 2.7 -0.5 -1.5 -0.8 -0.2 -1.1 -1.0 -0.4 1.3 0.7 -1.5 -0.2 -0.3 -0.8 -1.6 0.1
Sitting height 1.2 8.4 48.5 -0.5 -5.4 -2.8 -1.5 -4.0 -7.0 -1.5 2.7 2.3 -0.7 0.8 -1.0 -1.3 -2.1 0.1
Chronic bronchitis/emphysema (father) 1.0 1.2 2.6 -1.1 -0.6 -1.6 -1.5 -0.7 0.1 -0.8 1.6 -0.7 -0.9 -0.7 -0.5 -1.4 -1.6 -0.9
High blood pressure (mother) 0.3 0.4 1.8 -0.6 -0.2 -0.8 0.1 -0.1 -0.5 -0.0 -0.7 0.7 1.0 -0.2 -0.1 0.5 1.4 0.5
Body mass index (BMI) 0.7 2.8 8.9 -0.2 -2.9 1.1 0.1 -1.3 -3.0 0.9 1.6 2.8 -0.7 1.8 1.1 -0.0 -1.6 1.8
Impedance of leg (left) 0.3 1.3 4.4 1.4 1.2 0.7 0.6 0.7 2.0 -0.1 -1.5 -0.3 1.8 -0.4 -0.5 0.8 2.1 -0.2
Leg predicted mass (left) 1.3 7.0 34.6 -0.7 -4.8 0.2 -0.2 -2.5 -5.9 0.8 2.3 3.7 -0.8 2.8 1.3 -0.1 -2.3 2.1
Trunk fat mass 1.6 6.9 23.7 -0.0 -4.7 1.6 0.8 -2.1 -4.6 1.5 1.3 4.9 0.2 3.2 1.9 1.0 -0.8 3.2
Waist circumference 1.2 4.4 14.4 0.3 -3.5 1.5 0.8 -1.4 -3.5 1.5 1.2 3.8 -0.3 2.9 1.7 0.7 -0.9 2.5
Number of incorrect matches in round 0.6 1.1 3.8 -0.3 1.7 -0.2 -0.8 1.2 1.8 -0.3 0.0 -1.9 -0.1 -0.9 -0.9 -0.6 -0.4 -1.2
Past tobacco smoking 1.0 1.8 6.9 -0.6 2.6 1.9 0.3 1.8 1.1 0.3 -1.8 -1.0 1.9 -0.2 -0.2 0.7 1.7 -0.1
Alcohol usually taken with meals 2.0 3.2 9.0 -1.7 -0.5 -1.8 -1.8 -1.3 1.0 -2.4 1.1 -1.9 -1.0 -3.0 -2.4 -1.8 -0.3 -2.4
Nervous feelings 0.5 0.9 3.9 -0.6 1.0 -0.7 -0.4 0.7 2.0 -0.3 -0.6 -0.9 0.3 -1.6 -1.2 -0.1 0.7 -0.7
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.4 1.9 -0.4 -0.0 -1.4 -0.4 -0.1 -0.6 -0.3 0.1 -0.7 -0.6 -0.5 -1.1 -0.3 -0.8 -0.6
Hearing difficulty/problems with background noise 0.3 0.6 1.9 -0.1 -0.8 -0.4 0.9 -0.4 -1.3 0.7 -0.0 1.2 -0.3 0.7 0.0 0.7 -0.4 1.4
Hair/balding pattern: Pattern 2 1.2 1.5 4.6 -1.4 1.6 1.3 1.3 0.3 1.0 0.5 -2.1 0.6 1.6 0.4 0.4 1.6 1.6 1.0
Had menopause 0.6 0.7 3.1 -1.8 0.7 0.1 0.6 0.6 1.7 0.3 -1.0 0.1 0.6 -0.2 0.3 0.7 1.2 0.2
Had other major operations 0.8 1.0 3.1 -1.6 -1.7 -0.1 -0.2 -1.1 -1.8 -0.4 1.0 1.4 -1.0 0.5 0.2 -0.3 -0.1 0.4
Forced vital capacity (FVC) 0.6 2.5 12.6 1.3 -1.7 0.5 0.4 -0.2 -3.5 1.1 1.0 1.8 0.6 2.5 1.7 0.2 -1.4 1.5
Heel bone mineral density (BMD) T-score, automated (right) 1.1 2.5 5.7 -0.8 2.4 2.2 0.9 2.2 1.9 1.5 -1.5 0.1 2.3 0.8 1.1 1.3 1.6 0.7
Ever unenthusiastic/disinterested for a whole week 0.6 0.8 3.2 -0.1 0.4 -0.9 -0.7 -0.7 0.3 -1.2 -0.3 -1.2 -0.2 -1.2 -1.8 -0.5 -0.0 -1.4
Qualifications: None of the above 0.5 1.0 2.0 0.1 1.1 1.3 1.2 1.2 1.4 1.4 -0.8 0.6 0.7 1.0 0.4 1.1 0.3 1.1
Financial difficulties in last 2 years 0.6 0.8 2.7 0.3 -1.6 -0.4 -0.7 -1.1 -1.5 -0.4 1.2 1.0 -0.8 0.7 0.4 -0.7 -0.5 0.1
Mouth/teeth dental problems 0.7 1.0 4.4 -0.3 0.6 -0.8 -1.1 -0.6 0.4 -1.2 -0.1 -0.9 -2.1 -1.7 -1.3 -0.7 -0.2 -1.0
Heart attack 2.1 2.7 5.3 -0.6 -0.4 -1.0 -2.3 -0.4 -0.3 -1.4 2.2 -2.0 -1.6 -1.7 -2.0 -2.3 -1.9 -2.2
Allergy 0.1 0.2 0.7 -0.8 0.2 0.3 -0.0 0.2 -0.1 0.2 -0.4 0.3 0.5 0.2 -0.1 0.5 0.8 0.5
Pain all over the body in last month 1.3 1.4 3.2 1.8 0.3 0.8 1.2 1.3 0.9 1.8 -0.1 1.4 -0.4 1.6 1.8 0.8 0.1 1.3
Diabetes (self-reported) 0.9 1.4 6.3 0.4 -2.0 -0.0 -0.7 -1.3 -2.5 -0.4 1.5 0.8 -1.5 0.3 -0.2 -0.9 -1.4 -0.1
Hayfever/allergic rhinitis (self-reported) 0.3 0.4 1.5 -0.4 0.5 -1.0 -0.0 0.0 0.8 -0.7 -0.2 -1.0 -0.1 -1.2 -0.8 -0.3 0.4 -0.7
Medication: Ramipril 1.4 1.8 10.0 -0.0 -2.1 -1.0 -0.8 -2.1 -3.2 -0.9 1.3 0.8 -1.3 0.2 -0.0 -0.7 -1.3 -0.1
Medication: Simvastatin 0.3 0.4 1.5 -0.0 -0.9 1.0 -0.9 -0.6 -1.2 -0.1 0.8 0.5 -0.3 0.3 -0.4 -0.5 -0.6 -0.0
Fluid intelligence score 0.1 0.2 1.9 -1.4 0.1 -0.3 0.0 -0.3 -0.3 -0.3 -0.4 -0.3 0.7 0.4 -0.1 0.1 -0.1 -0.2
Illnesses of siblings 0.6 0.8 2.8 1.3 1.5 0.6 -0.6 0.7 0.9 -0.4 -0.4 -1.7 1.0 -0.9 -0.6 -0.4 0.2 -1.1
Neuroticism score 0.4 0.8 3.7 -0.2 1.2 0.5 -0.4 1.4 1.9 0.3 0.3 -1.4 -0.6 -0.9 -0.5 -0.5 -0.9 -0.6
Weight 1.7 8.4 35.5 -0.2 -5.5 0.7 -0.2 -2.9 -6.0 0.8 2.7 4.5 -1.0 2.9 1.4 -0.2 -2.4 2.4
Impedance of arm (right) 0.7 3.1 8.6 0.4 2.1 0.3 1.9 1.6 2.5 1.1 -2.9 0.2 2.1 0.6 0.5 2.2 2.9 1.1
Arm fat percentage (right) 0.7 2.6 9.4 0.0 -2.2 1.6 1.0 -0.7 -2.2 1.5 0.4 3.1 0.2 2.2 1.4 1.0 -0.4 2.4
Trunk fat-free mass 1.3 7.7 39.4 -0.0 -5.1 -0.2 -1.2 -3.0 -6.3 -0.1 3.3 3.0 -1.2 2.3 0.9 -1.2 -3.2 1.1
Hip circumference 0.9 3.7 17.8 -0.2 -3.8 0.6 -0.2 -2.2 -4.2 0.2 1.9 2.7 -0.7 1.7 0.4 -0.4 -1.6 1.3
Time employed in main current job 1.7 2.0 8.7 -1.0 -2.2 -1.7 -0.2 -2.6 -2.9 -1.3 0.3 1.2 0.3 0.0 -1.4 0.0 -0.0 0.1
Alcohol intake versus 10 years previously 0.8 1.2 5.2 2.3 -0.5 -1.3 1.0 -0.3 0.0 0.9 -0.7 1.4 -0.8 1.0 1.2 1.1 0.0 1.5
Father’s age at death 1.7 2.3 8.7 -1.5 0.3 0.5 2.0 -0.3 -0.3 0.5 -2.5 1.5 1.6 0.8 0.1 2.1 3.0 1.4
Worrier / anxious feelings 1.7 3.3 9.0 -0.7 0.7 -0.5 -2.2 0.8 1.9 -1.3 1.6 -3.0 -1.2 -2.3 -2.3 -2.2 -1.5 -2.5
Frequency of tiredness / lethargy in last 2 weeks 0.2 0.4 1.0 -1.0 0.2 0.4 -0.6 0.5 -0.0 -0.3 0.5 -1.0 0.4 -0.4 -0.8 -0.8 -0.7 -0.7
Falls in the last year 1.1 1.5 4.6 0.4 1.0 2.1 1.5 1.9 0.9 1.9 -1.0 0.5 0.9 1.1 0.6 1.2 0.8 1.1
Hair/balding pattern: Pattern 3 1.5 2.2 5.4 0.5 0.7 -0.3 -1.5 -0.5 1.1 -1.7 1.0 -2.3 -1.4 -2.3 -1.9 -1.7 -0.8 -2.3
Number of live births 0.2 0.2 1.2 1.1 -0.3 0.1 0.5 -0.2 -0.8 -0.0 0.2 0.4 -1.0 -0.3 0.0 0.1 -0.1 0.3
Forced expiratory volume in 1-second (FEV1) 0.6 1.9 9.5 1.0 -1.5 0.4 0.5 -0.1 -3.1 1.0 0.7 1.5 0.5 2.3 1.6 0.2 -1.2 1.2
Pulse rate 1.3 2.1 9.7 -0.3 1.8 -0.5 -0.9 1.6 3.1 -0.3 0.8 -2.4 -1.3 -1.0 0.3 -1.2 -1.4 -1.6
Happiness 1.4 1.7 5.7 0.8 2.4 1.0 1.6 1.2 1.0 0.9 -2.4 -0.3 0.8 0.6 0.3 1.6 1.6 0.4
Noisy workplace 0.1 0.1 0.5 0.3 -0.6 0.1 0.1 0.0 -0.2 0.5 0.3 0.6 -0.1 0.7 0.3 0.2 -0.2 0.4
Qualifications: A levels/AS levels or equivalent 0.3 0.6 5.0 -0.9 -0.5 0.4 0.0 -0.4 -0.2 -0.5 -0.7 0.1 2.2 0.0 0.4 0.3 1.1 0.0
Serious illness, injury or assault of a close relative in last 2 years 0.6 0.7 4.0 -2.0 0.2 1.3 0.3 -0.0 -0.2 0.0 -0.8 0.4 1.4 0.5 0.0 0.6 0.9 0.3
Mouth/teeth dental problems: Dentures 0.4 0.7 2.0 -0.2 -0.6 -0.8 0.9 0.1 -0.3 0.9 -0.2 0.9 0.9 1.4 1.4 0.7 0.4 0.9
Asthma 1.5 3.0 5.6 0.9 -0.6 -1.3 -1.9 -1.1 -1.3 -2.0 2.0 -2.1 -1.7 -2.0 -1.7 -2.4 -1.9 -2.2
Medication: Ibuprofen (e.g. Nurofen) 1.2 1.5 5.4 1.5 -1.5 -0.5 -1.0 -1.1 -2.2 -0.5 1.6 -0.3 -0.9 -0.4 -0.9 -1.0 -2.3 -0.2
Medication: Cholesterol lowering 0.2 0.3 1.3 0.6 -0.1 1.1 -0.8 -0.2 -0.5 -0.1 0.6 -0.3 0.1 0.1 -0.2 -0.5 -0.9 -0.5
Depression (self-reported) 0.4 0.5 1.5 0.3 1.0 1.2 0.2 1.0 1.2 0.5 -0.4 -0.9 0.3 -0.3 -0.9 0.2 0.2 -0.5
Medication: Lansoprazole 0.4 0.5 1.5 0.1 0.3 0.4 -1.0 0.9 -0.1 -0.0 1.2 -0.9 -0.3 -0.2 -0.2 -1.2 -0.9 -0.7
Prospective memory result 0.2 0.2 1.6 0.0 0.1 -1.3 0.1 0.5 0.6 0.5 0.3 0.1 -0.5 0.3 0.6 -0.0 -0.3 0.2
Lung cancer (father) 1.7 2.0 5.7 1.3 -0.0 1.8 -0.4 1.7 0.3 1.5 1.9 -0.2 -1.5 1.8 2.4 -0.7 -2.2 0.3
Illnesses of mother 0.3 0.3 1.7 0.9 -0.0 0.9 -0.2 0.1 0.4 -0.1 0.6 -0.3 -1.3 -0.2 -0.3 -0.5 -0.7 -0.4
Forced expiratory volume in 1-second (FEV1), Best measure 0.4 1.2 4.1 0.6 -1.0 0.6 -0.2 0.4 -2.0 0.8 1.6 0.6 -0.2 1.7 1.1 -0.6 -1.9 0.4
Pulse wave Arterial Stiffness index 1.1 1.2 4.1 0.9 -1.1 -0.6 -1.2 -0.6 0.2 -0.7 1.7 -0.4 -2.0 -1.0 -0.9 -1.3 -1.7 -0.8
Impedance of arm (left) 0.4 1.8 6.4 0.6 1.5 0.2 1.3 1.1 2.1 0.6 -2.3 -0.1 1.6 0.1 0.1 1.6 2.5 0.5
Arm fat mass (right) 1.2 4.8 16.7 0.0 -3.8 1.2 0.5 -1.7 -4.1 1.2 1.6 3.7 -0.4 2.6 1.5 0.4 -1.4 2.4
Trunk predicted mass 1.4 7.9 40.2 -0.1 -5.2 -0.3 -1.3 -3.1 -6.3 -0.1 3.4 3.0 -1.4 2.2 0.9 -1.3 -3.2 1.1
Standing height 1.0 9.7 48.8 0.0 -6.2 -0.4 -0.5 -3.6 -7.0 0.2 2.5 4.3 -0.5 3.1 1.2 -0.2 -1.9 2.0
Length of working week for main job 0.7 0.8 3.3 0.2 -0.7 1.3 0.1 -0.0 -0.8 0.6 0.3 0.8 0.7 1.8 1.7 0.3 -0.3 1.0
Exposure to tobacco smoke at home 1.0 1.1 7.4 0.1 -0.8 -0.2 -0.5 -0.1 0.3 0.4 1.7 -0.3 -1.8 0.6 0.9 -0.9 -2.7 -0.0
Breastfed as a baby 1.2 1.5 7.8 1.1 2.8 0.2 -0.0 1.8 1.5 0.5 -1.2 -1.7 0.8 -0.3 0.1 0.3 1.1 -1.0
Tense / ‘highly strung’ 0.4 0.6 2.8 0.4 0.7 -0.2 -0.2 -0.0 1.0 -0.6 -0.5 -0.9 -0.0 -1.7 -1.4 -0.0 0.4 -0.9
Seen doctor (GP) for nerves, anxiety, tension or depression 0.4 0.6 1.4 -1.1 1.0 0.8 0.0 0.5 0.7 0.0 -0.4 -1.0 -1.1 -1.2 -1.2 0.1 -0.1 -0.5
Hair/balding pattern: Pattern 4 1.8 4.4 9.7 0.7 -0.4 0.5 2.8 1.6 0.1 3.0 -1.5 3.0 1.5 2.9 2.2 2.5 1.5 3.1
Birth weight of first child 1.5 2.8 11.3 -0.8 -2.9 -1.1 -1.9 -2.4 -3.4 -1.0 2.0 1.1 -1.0 0.3 -0.8 -1.2 -1.4 -0.4
Peak expiratory flow (PEF) 0.8 1.9 15.3 0.4 -2.0 -0.9 -0.3 -0.8 -3.9 0.2 1.2 1.3 -0.3 1.1 0.8 -0.5 -1.3 0.7
Pulse wave reflection index 0.4 0.5 1.2 0.6 -1.0 -0.2 -0.7 -0.7 -0.2 -0.4 1.1 0.1 -0.5 -0.5 -1.0 -0.7 -1.1 -0.0
Ever highly irritable/argumentative for 2 days 0.3 0.4 2.8 1.7 0.4 0.3 -0.6 0.2 0.4 -0.1 0.3 -0.5 -0.9 -0.5 -0.4 -0.5 -0.8 -0.3
Loud music exposure frequency 0.3 0.3 0.9 -0.2 0.9 0.3 0.3 0.8 0.8 0.2 0.2 -0.9 -0.3 -0.1 -0.1 -0.2 -0.7 -0.5
Qualifications: O levels/GCSEs or equivalent 1.5 2.4 6.3 0.3 -2.5 -1.9 -1.9 -2.1 -1.3 -1.9 1.9 -0.2 -1.0 -1.1 -0.6 -1.8 -1.3 -1.1
Mouth/teeth dental problems: Bleeding gums 1.4 1.8 7.0 0.8 0.7 1.3 1.7 1.6 0.4 1.4 -1.2 0.7 2.6 1.2 0.6 1.3 1.6 1.3
Blood clot in the leg (DVT) 2.2 2.8 5.0 0.9 0.7 1.8 2.2 1.8 0.8 2.2 -1.1 1.3 2.0 2.2 2.0 1.6 0.9 1.9
Medication: Paracetamol 0.5 0.8 2.1 0.2 0.3 -0.5 -1.4 0.0 0.4 -0.7 0.9 -1.4 -0.2 -0.7 -1.5 -1.0 -1.4 -1.0
Headache pain in last month 0.3 0.6 2.9 -0.5 1.5 -0.1 -0.0 1.7 0.7 0.8 -0.4 -0.7 1.0 0.8 0.1 0.0 -0.2 0.1
Medication for cholesterol, blood pressure or diabetes 0.7 1.1 4.0 -0.0 0.3 -0.4 2.0 0.6 0.4 0.9 -1.5 1.1 0.8 0.6 0.6 1.5 1.7 1.3
Glaucoma (self-reported) 0.5 0.6 2.2 0.3 0.2 1.5 0.4 0.9 0.2 0.7 -0.3 0.7 1.5 0.9 0.1 0.4 1.0 0.7
Gout (self-reported) 0.8 1.0 2.2 -0.5 0.0 0.9 1.4 0.9 0.1 1.4 -0.8 1.2 0.8 1.5 1.0 1.2 0.8 1.3
Hypothyroidism/myxoedema (self-reported) 1.2 2.3 4.8 -0.8 -1.9 -1.4 -1.1 -2.1 -1.8 -1.3 1.7 0.1 -2.2 -1.0 -1.4 -1.3 -2.0 -0.8
Medication: Amlodipine 1.1 1.5 3.0 -0.7 -0.7 -0.8 -1.4 -0.9 -1.3 -1.7 1.2 -1.2 -0.5 -1.5 -1.7 -1.6 -0.9 -1.3
Medication: Ventolin 100micrograms inhaler 0.3 0.4 1.9 -0.4 0.1 0.4 -0.7 0.1 -0.3 -0.2 0.8 -0.7 -0.8 -0.6 -0.5 -0.7 -1.4 -0.3
Birth weight 0.2 0.5 3.1 0.3 -1.1 0.1 -0.3 -1.4 -1.8 -0.6 0.2 0.7 0.4 0.1 -0.5 -0.0 -0.1 0.1
Chronic bronchitis/emphysema (mother) 0.8 0.9 8.2 -2.9 -1.2 0.1 -0.0 -0.7 -0.5 0.0 0.7 1.1 -0.8 0.5 0.5 0.1 -0.2 0.7
High blood pressure (siblings) 0.3 0.4 0.9 -0.9 -0.9 -0.1 0.3 -0.2 -0.2 0.4 0.4 0.9 0.2 0.9 0.9 0.3 -0.4 0.8
Forced vital capacity (FVC), Best measure 0.4 1.5 4.9 0.4 -1.2 0.7 -0.2 0.5 -2.2 1.0 1.7 0.8 0.0 1.9 1.3 -0.6 -2.0 0.7
Body fat percentage 1.1 4.2 16.5 0.1 -3.2 1.8 1.2 -1.4 -2.9 1.5 0.4 4.1 0.6 2.5 1.6 1.3 0.1 2.8
Leg fat percentage (right) 0.7 2.7 10.2 0.6 -3.1 1.4 0.6 -1.7 -2.4 0.7 0.8 3.2 -0.1 1.6 1.1 0.6 -0.6 2.0
Arm fat-free mass (right) 1.5 7.9 35.7 -0.1 -5.6 0.1 -1.0 -3.2 -6.0 -0.1 3.3 3.4 -1.1 2.3 1.0 -1.1 -2.8 1.4
Exposure to tobacco smoke outside home 0.2 0.3 1.1 -0.8 -0.1 0.3 -1.0 0.5 -0.3 -0.0 0.8 -0.4 0.6 -0.1 -0.4 -0.7 -0.6 -0.3
Comparative body size at age 10 0.4 1.0 4.4 0.1 1.5 1.7 0.5 1.5 2.1 0.8 -0.3 -0.5 -0.3 -0.1 1.2 0.2 -0.2 0.2
Number of full brothers 0.4 0.5 1.2 0.4 -0.6 -1.1 -0.5 -0.3 -0.5 -0.4 1.1 -0.3 -0.9 -0.7 -0.9 -0.9 -0.3 -0.7
Worry too long after embarrassment 0.7 1.2 3.1 -0.7 0.3 0.3 -1.2 0.6 1.3 -0.4 1.0 -1.6 -1.8 -1.2 -1.0 -1.1 -1.1 -1.2
Seen a psychiatrist for nerves, anxiety, tension or depression 1.1 1.4 5.3 -1.3 1.6 0.5 1.4 0.8 0.3 0.5 -2.3 -0.4 0.9 -0.1 0.1 1.6 2.0 0.4
Wheeze or whistling in the chest in last year 0.3 0.5 2.8 0.2 -1.2 -0.3 0.1 -1.0 -1.7 0.0 0.1 1.2 -0.5 0.5 -0.4 0.3 0.0 0.4
Number of children fathered 0.7 0.8 3.2 0.5 -1.8 -0.3 -0.6 -0.8 -1.2 -0.1 1.4 0.9 -0.9 0.1 0.2 -0.7 -1.3 0.5
Reason for reducing amount of alcohol drunk: Health precaution 0.8 0.9 3.6 -1.9 -0.2 -0.9 -0.8 -0.9 0.9 -1.1 -0.2 -0.3 -1.2 -1.4 -1.0 -0.1 0.8 -0.7
Age at first live birth 0.5 1.0 3.0 -1.7 0.2 -1.7 -0.3 -0.4 0.0 -1.0 -0.8 -0.7 1.1 -1.0 -1.0 -0.0 1.4 -1.0
Pulse wave peak to peak time 1.0 1.2 4.5 -1.0 0.7 0.6 1.1 0.3 -0.7 0.5 -1.5 0.6 2.1 1.0 0.9 1.2 1.7 0.8
Health satisfaction 0.5 0.7 3.3 -0.2 -0.9 -1.2 0.3 -1.4 -1.8 -0.1 -0.4 1.0 -0.4 0.5 -0.1 0.5 -0.4 0.6
Shortness of breath walking on level ground 0.2 0.3 2.4 0.6 -0.7 -1.5 -0.0 -0.5 -0.3 -0.1 0.2 0.2 -0.5 -0.1 -0.4 -0.1 -0.1 -0.1
Qualifications: College or University degree 0.4 1.2 4.9 -0.9 1.4 0.6 1.1 0.3 -0.1 -0.1 -2.2 -0.5 1.7 0.0 -0.5 1.3 2.0 -0.1
Eye problems/disorders: None of the above 0.8 0.9 2.8 0.7 0.2 -0.9 -0.7 -0.8 1.0 -1.1 0.2 -1.2 -1.5 -1.7 -0.4 -0.5 -0.7 -1.3
Mouth/teeth dental problems: Loose teeth 0.5 0.6 2.3 -0.0 1.5 -0.1 0.4 0.8 1.2 0.2 -0.8 -0.9 1.4 -0.6 -0.2 0.3 0.7 -0.8
Emphysema/chronic bronchitis 1.3 1.4 3.7 -0.4 -0.8 -0.7 -1.1 -1.7 -0.6 -1.7 0.9 -0.9 -0.8 -1.9 -1.7 -1.1 -0.8 -1.4
Medication for pain relief, constipation, heartburn 1.2 2.0 5.7 -0.4 -0.5 0.6 1.9 -0.1 0.1 1.1 -1.5 2.3 1.0 1.5 1.8 1.7 2.4 1.6
Neck or shoulder pain in last month 0.8 1.1 3.6 1.4 0.2 1.9 1.2 1.2 -0.2 1.6 -0.5 0.7 0.4 1.1 0.7 1.1 0.0 1.3
Medication: Blood pressure 3.0 5.3 12.3 -0.6 -0.7 -1.6 -3.5 -1.7 -0.8 -2.9 2.5 -2.6 -1.8 -2.5 -2.4 -3.0 -2.3 -3.1
Angina (self-reported) 0.2 0.3 1.7 1.3 0.4 -0.0 -0.6 0.3 0.0 -0.2 0.2 -0.8 0.1 -0.1 -0.3 -0.5 -0.2 -0.8
Migraine (self-reported) 0.5 0.6 3.3 -0.3 0.5 -1.8 -1.0 -0.0 0.9 -0.7 0.1 -1.0 -0.5 -0.8 -0.7 -0.7 -0.6 -0.6
Medication: Ibuprofen 2.4 2.8 9.6 1.0 -1.8 -1.3 -1.7 -1.3 -2.5 -1.0 2.4 -0.8 -1.6 -0.7 -1.2 -1.8 -3.1 -0.8
Medication: Allopurinol 0.4 0.5 1.7 -0.5 0.1 0.5 0.8 0.9 -0.0 1.3 -0.0 0.6 -0.3 1.1 0.9 0.6 -0.7 1.0
Medication: Omeprazole 0.4 0.4 2.8 1.1 -0.5 -0.5 0.0 -0.9 -1.7 -0.4 -0.1 0.3 -0.8 -0.2 -0.6 0.2 -0.1 0.1
Medication: Seretide 50 evohaler 1.4 1.6 5.0 0.9 -2.0 -0.9 -1.3 -1.2 -2.2 -0.5 1.9 0.8 -1.2 -0.3 -0.7 -1.1 -1.4 -0.0
Mean time to correctly identify matches 1.1 2.1 4.5 -0.3 -0.3 1.1 2.1 0.1 -0.8 1.5 -1.3 1.9 1.3 2.0 1.4 1.9 1.3 2.0
Heart disease (mother) 2.3 2.8 5.1 -0.5 -1.6 -1.8 -1.9 -2.0 -1.7 -2.3 1.7 -1.1 -0.8 -1.7 -1.8 -1.9 -1.3 -2.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.1 1.3 3.9 0.1 -1.4 -1.2 -0.5 -2.0 -1.1 -1.5 -0.1 0.5 -1.3 -1.5 -1.6 -0.3 0.8 -0.7
Whole body fat mass 1.5 6.1 22.0 -0.0 -4.7 1.2 0.4 -2.3 -4.6 1.1 1.6 4.4 -0.2 2.7 1.5 0.5 -1.2 2.6
Leg fat mass (right) 1.5 5.7 21.5 0.0 -4.6 1.1 0.3 -2.5 -4.4 0.9 1.8 4.1 -0.6 2.4 1.2 0.3 -1.6 2.4
Arm predicted mass (right) 1.7 8.6 38.4 -0.0 -5.7 -0.1 -1.4 -3.3 -6.2 -0.3 3.7 3.2 -1.5 2.0 0.7 -1.5 -3.2 1.1
Pulse rate, automated reading 0.3 1.1 6.6 0.7 1.3 0.5 0.8 1.8 2.6 1.1 -0.7 -0.1 0.4 0.4 0.9 0.7 0.4 0.5
Alcohol intake frequency. 0.5 1.1 4.1 1.4 2.0 0.2 0.1 2.0 1.5 0.9 -0.7 -1.0 0.8 0.4 0.0 0.4 -0.4 0.4
Comparative height size at age 10 0.7 4.0 17.5 1.2 -3.6 1.1 -0.1 -1.2 -4.2 1.1 1.4 2.9 0.5 2.9 1.3 0.2 -1.1 1.7
Number of full sisters 0.6 0.7 3.4 1.9 -0.5 0.9 0.9 -0.1 -0.3 0.5 0.0 0.8 0.9 1.3 0.7 0.5 -0.4 0.9
Suffer from ‘nerves’ 0.3 0.5 2.0 -1.4 -0.5 -0.4 0.8 -0.4 0.4 0.1 -0.9 0.9 0.4 -0.6 -0.7 0.9 0.9 0.6
Overall health rating 0.6 1.2 6.0 0.3 -1.4 -0.6 -1.0 -0.8 -2.4 -0.2 1.3 0.4 -0.6 0.1 -1.1 -0.8 -2.0 -0.0
Chest pain or discomfort 0.1 0.1 0.4 0.5 -0.2 -0.5 0.5 -0.3 -0.4 0.2 -0.3 0.3 -0.7 0.1 -0.2 0.5 -0.1 0.0
Had major operations 0.4 0.5 2.3 1.2 -0.6 -0.3 -0.4 -0.8 -1.5 -0.6 0.6 -0.2 0.3 0.3 -0.3 -0.6 -0.3 -0.8
Age at last live birth 0.4 0.6 1.7 0.3 0.5 -0.6 1.3 0.2 0.7 0.4 -1.3 0.6 0.2 0.1 0.4 1.1 1.2 0.7
Family relationship satisfaction 0.2 0.3 1.3 -1.2 -0.2 -0.3 0.3 -0.2 0.8 0.2 -0.5 0.7 -0.6 0.2 0.5 0.4 0.3 0.4
Leg pain on walking 1.0 1.2 4.5 -0.7 -1.4 -1.2 -1.2 -1.3 -2.1 -0.7 1.3 0.2 -1.1 -0.3 -0.3 -0.9 -1.5 -0.3
Qualifications: NVQ or HND or HNC or equivalent 0.6 0.7 1.6 -0.6 0.2 -1.0 -1.3 0.9 0.8 -0.1 1.1 -1.1 -0.4 -0.8 0.2 -1.1 -0.9 -0.7
Commuting to job workplace: Car/motor vehicle 1.4 1.6 5.5 1.2 -0.3 1.2 1.5 0.8 -0.0 1.8 -0.4 1.5 -0.1 1.7 2.3 1.2 0.4 1.5
Illness, injury, bereavement, stress in last 2 years 0.4 0.5 1.6 0.4 1.0 -0.3 -0.4 0.5 1.2 -0.3 0.0 -1.1 -0.5 -1.3 -0.6 -0.5 -0.3 -0.9
Medication: Aspirin 0.6 0.8 2.7 -0.7 1.6 0.8 0.4 1.1 1.5 0.2 -0.9 -1.3 1.1 -0.6 -0.3 0.3 0.5 -0.4
Supplements: Vitamin C 1.1 1.3 3.6 1.6 1.1 1.3 1.0 1.5 1.9 1.4 -1.0 0.1 -0.6 0.7 1.3 1.0 0.6 0.7
Knee pain experienced in last month 0.3 0.5 1.3 -1.1 -1.1 0.7 -0.1 -0.3 -0.8 0.4 0.8 1.1 -0.6 0.5 -0.4 -0.1 -0.7 0.7
Hypertension (Self-reported) 0.1 0.2 0.6 -0.2 0.4 0.4 -0.6 0.3 0.2 -0.1 0.4 -0.8 -0.1 -0.0 -0.1 -0.5 -0.4 -0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.2 0.2 1.1 1.0 0.5 0.9 0.4 0.5 -0.5 0.2 -0.3 -0.2 -0.3 0.2 0.3 0.2 0.3 0.0
Illnesses of father: Heart disease 0.7 1.0 4.8 1.0 0.7 -0.2 0.0 0.4 1.6 -0.6 -0.7 -0.7 0.9 -1.3 -2.2 -0.0 1.2 -0.7
Illnesses of siblings: Diabetes 0.6 0.8 3.5 0.0 -1.1 -0.7 -0.3 -0.5 -1.3 0.2 1.3 0.8 -1.9 0.7 0.1 -0.5 -1.1 0.4
Smoking status: Previous 1.3 1.9 6.5 0.1 -2.5 -2.4 -0.4 -2.1 -1.1 -0.7 1.4 0.7 -2.0 -0.5 -0.6 -0.6 -1.4 -0.2
Forced expiratory volume in 1-second (FEV1), predicted 0.9 1.9 13.6 0.8 -2.1 -0.1 0.4 -1.3 -3.7 0.2 0.0 2.0 1.1 1.5 0.0 0.6 0.3 1.0
Whole body fat-free mass 1.3 7.7 39.4 -0.4 -5.1 -0.0 -0.9 -2.9 -6.3 0.2 3.0 3.4 -1.1 2.5 1.0 -0.9 -2.9 1.5
Leg fat-free mass (right) 1.3 7.0 35.2 -1.0 -4.8 0.0 -0.4 -2.5 -5.9 0.7 2.4 3.5 -0.9 2.7 1.2 -0.4 -2.5 1.9
Arm fat percentage (left) 0.7 2.7 9.8 -0.2 -2.6 1.4 0.8 -1.0 -2.5 1.2 0.6 3.1 0.2 2.1 1.3 0.9 -0.4 2.2
Average weekly red wine intake 0.3 0.4 1.2 0.6 0.6 1.1 0.1 1.1 0.7 0.8 -0.1 -0.1 0.6 0.5 1.0 0.2 -0.0 0.2
Handedness (chirality/laterality): Left-handed 0.4 0.5 4.1 -2.0 0.3 0.5 -0.5 0.7 0.5 0.4 0.7 0.2 -0.3 0.3 0.6 -0.3 -0.6 0.4
Mood swings 0.9 1.6 4.7 -1.1 0.9 0.7 -1.2 0.5 1.9 -0.7 0.6 -2.2 -0.9 -1.7 -1.4 -1.1 -1.2 -1.5
Loneliness, isolation 1.0 1.4 5.5 0.5 1.7 -1.3 -0.7 0.5 2.4 -0.8 -0.3 -1.8 -0.2 -1.3 -1.2 -0.7 -0.4 -1.3
Long-standing illness, disability or infirmity 1.4 2.1 10.0 0.3 -3.2 -0.6 -0.6 -2.5 -2.6 -0.8 1.2 1.9 -0.8 0.2 -0.5 -0.3 -0.5 0.5
Ever had bowel cancer screening 1.8 2.1 8.1 0.3 -0.0 -0.7 -1.3 -0.6 0.8 -1.3 1.4 -1.8 -2.8 -2.0 -0.9 -1.6 -1.9 -1.5
Diabetes diagnosed by doctor 0.6 0.9 5.3 0.1 -1.5 -0.3 -0.4 -1.0 -2.3 -0.1 1.2 0.6 -1.4 0.2 -0.3 -0.7 -1.2 -0.1
Ever had stillbirth, spontaneous miscarriage or termination 2.0 2.2 8.4 0.9 -1.7 0.0 1.5 -1.3 -1.9 0.6 -1.2 2.9 0.1 1.3 0.4 1.7 1.5 1.9
Friendships satisfaction 0.8 1.0 4.1 0.5 1.1 -0.3 0.9 0.5 0.1 0.4 -1.9 0.3 1.4 0.7 0.2 1.3 2.0 0.7
Qualifications: nursing, teaching 0.3 0.4 1.5 -0.4 0.9 1.2 0.7 1.1 0.0 0.9 -0.5 -0.1 -0.0 0.6 0.8 0.4 -0.1 0.3
Commuting to job workplace: Walk 0.4 0.5 1.8 1.0 0.4 1.0 0.0 1.0 0.5 0.5 0.4 -0.3 0.1 0.5 1.3 -0.3 -0.9 0.1
Eye problems/disorders: Cataract 0.3 0.4 1.2 -1.0 0.3 0.2 -0.3 0.9 0.1 0.6 0.7 -0.7 0.1 0.6 0.4 -0.4 -1.1 -0.1
Mouth/teeth dental problems: Mouth ulcers 0.4 0.6 1.9 1.2 -0.5 0.5 1.1 0.2 -1.4 0.8 0.1 0.6 1.1 1.0 0.6 0.4 -0.1 0.4
Medication for cholesterol 0.2 0.3 1.1 -0.8 -0.3 -0.6 -0.6 -0.7 0.0 -0.6 0.2 -0.1 -1.0 -0.5 -0.1 -0.4 -0.4 -0.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.4 0.5 1.5 -1.2 1.1 1.2 -0.2 0.7 1.1 0.3 -0.1 -0.8 0.1 0.1 0.4 -0.0 -0.4 -0.3
Back pain experienced in last month 0.5 0.7 2.5 0.2 -0.6 0.9 0.9 -0.8 -1.6 0.3 -0.5 1.1 1.1 0.8 -0.2 0.8 -0.2 0.9
Mineral and other dietary supplements 0.8 1.1 3.0 -0.6 1.5 0.1 1.1 1.2 -0.4 1.1 -1.3 0.2 1.7 1.1 0.4 1.2 1.1 0.9
Breast cancer (self-reported) 0.9 1.0 2.5 -0.2 0.2 0.1 1.0 0.4 0.8 1.0 -1.5 1.1 0.4 1.0 1.5 1.6 1.2 1.5
Asthma (self-reported) 1.9 3.9 7.0 0.7 -0.8 -1.7 -2.3 -1.3 -1.4 -2.4 2.2 -2.2 -1.6 -2.3 -2.0 -2.6 -2.0 -2.5
Osteoporosis (self-reported) 3.8 4.7 9.0 2.5 1.7 2.5 2.3 2.0 1.4 2.1 -2.1 1.1 3.0 2.7 2.1 2.2 2.0 1.8
Osteoarthritis (self-reported) 1.3 1.7 4.8 0.2 -2.1 -0.7 -1.5 -2.2 -1.6 -1.5 1.5 0.6 -1.0 -0.9 -1.4 -1.1 -0.5 -0.4
Medication: Aspirin 0.7 0.9 2.6 -0.4 1.6 0.9 0.8 1.2 1.4 0.5 -1.1 -0.9 1.3 -0.2 -0.1 0.7 0.7 -0.0
Medication: Gliclazide 0.6 0.7 1.8 0.7 -1.2 0.4 0.9 -0.0 -0.7 0.9 0.3 1.2 -0.2 1.2 1.3 0.5 -0.6 1.2
Illnesses of father: None of the above (group 1) 0.7 0.9 3.5 0.4 0.6 1.3 0.8 0.9 -0.6 1.2 -0.3 0.0 -1.2 1.2 1.9 0.8 -0.3 0.9
Smoking status: Current 0.5 0.8 2.4 1.0 -0.4 1.6 0.3 0.9 0.8 1.0 0.9 0.9 0.8 1.4 1.2 -0.2 -0.3 0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.3 0.6 2.7 0.0 1.2 1.7 0.5 1.2 1.2 0.7 -0.2 -0.8 -0.6 0.2 0.1 0.2 -0.6 -0.0
Whole body water mass 1.3 7.7 39.7 -0.3 -5.1 -0.1 -0.8 -2.9 -6.3 0.2 3.0 3.3 -1.0 2.5 1.1 -0.9 -2.9 1.6
Leg predicted mass (right) 1.3 6.8 34.8 -1.1 -4.7 0.0 -0.5 -2.5 -5.9 0.6 2.4 3.5 -0.9 2.7 1.2 -0.4 -2.5 1.9
Arm fat mass (left) 1.2 4.9 17.0 -0.2 -3.9 1.2 0.4 -1.8 -4.1 1.2 1.7 3.7 -0.6 2.6 1.4 0.3 -1.6 2.4
Number of self-reported non-cancer illnesses 0.2 0.3 1.0 0.3 -0.6 -0.3 -0.4 -0.8 -0.8 -0.9 0.4 -0.4 -0.2 -0.6 -1.0 -0.5 0.1 -0.5
Average weekly champagne plus white wine intake 1.2 1.7 5.9 1.1 0.6 -0.4 -1.2 -0.8 -0.1 -1.7 0.1 -2.0 -0.3 -2.0 -2.4 -1.0 -0.4 -1.8
Miserableness 0.4 0.7 4.1 -0.5 0.8 0.4 -0.6 0.8 2.0 0.1 0.6 -1.0 -0.9 -0.7 -0.1 -0.6 -1.1 -0.6
Guilty feelings 0.5 0.7 3.4 -0.8 1.0 0.6 0.0 1.8 1.3 1.3 -0.2 -0.4 -0.0 0.7 0.9 0.3 -0.7 0.7
Wears glasses or contact lenses 0.6 0.6 3.1 0.6 1.0 1.8 1.0 0.7 0.6 0.9 -0.9 0.1 -0.3 0.4 0.6 0.8 0.4 0.4
Ever taken oral contraceptive pill 0.7 0.7 2.9 0.3 -0.6 1.2 -0.1 -0.3 -1.7 0.6 0.1 1.2 1.0 1.5 0.7 0.4 -0.1 0.9
Hearing aid user 1.0 1.1 3.4 0.6 -0.4 0.8 0.6 0.2 -0.4 1.1 0.5 0.7 -1.3 1.6 1.8 0.3 -1.7 1.3
Mother’s age at death 0.8 1.0 3.9 -2.0 1.4 0.3 0.7 0.7 1.0 0.3 -1.4 -0.3 1.4 -0.2 0.1 0.6 1.5 -0.0
Financial situation satisfaction 0.6 0.7 2.9 1.0 -1.1 0.7 0.6 -0.8 -0.8 0.4 0.0 1.7 -0.1 1.3 0.9 0.4 0.1 1.1
Tinnitus: Yes, now most or all of the time 0.8 0.9 2.5 1.5 0.7 0.4 1.0 0.8 1.6 0.8 -1.1 0.2 1.1 0.2 0.1 1.1 1.2 0.8
Commuting to job workplace: Public transport 0.3 0.4 1.3 -1.1 0.1 -0.4 0.4 -0.7 0.1 -0.6 -1.0 -0.3 0.8 -0.3 -0.2 0.5 0.9 -0.3
Eye problems/disorders: Glaucoma 0.2 0.3 1.8 -0.2 0.3 1.3 -0.2 1.0 0.4 0.5 0.3 -0.1 0.7 0.5 0.1 -0.2 0.2 0.1
Medication: Blood pressure 0.1 0.1 0.7 0.5 0.5 0.2 0.4 0.8 0.7 0.4 -0.1 -0.0 0.2 0.2 -0.0 0.1 0.4 0.0
Pain type(s) experienced in last month: Hip pain 0.1 0.1 0.8 0.9 0.2 0.5 -0.2 0.2 0.0 0.1 0.2 -0.4 -0.4 -0.0 -0.8 -0.2 -0.2 -0.3
Supplements: Fish oil (including cod liver oil) 0.8 1.1 3.6 0.5 -1.3 0.2 -0.9 -1.5 -0.1 -1.2 1.0 -0.4 -1.9 -1.2 -0.5 -1.1 -1.1 -1.1
High cholesterol (Self-reported) 0.4 0.7 1.3 1.0 0.8 1.0 0.5 1.1 0.2 1.1 -0.6 0.5 1.2 0.9 0.8 0.8 0.3 0.9
Medication: Bendroflumethiazide 0.3 0.5 1.4 0.5 1.0 -0.6 -0.6 0.6 0.7 -0.4 -0.1 -1.2 0.6 -0.7 -0.7 -0.5 0.2 -0.9
Medication: Paracetamol 1.2 1.8 4.2 0.5 -0.4 -0.9 -1.9 -0.6 -0.2 -1.2 1.6 -1.4 -1.3 -1.1 -1.9 -1.6 -2.0 -1.4
Medication: Lisinopril 0.2 0.3 0.8 -0.9 0.2 0.8 -0.4 0.9 0.2 0.6 0.8 -0.1 0.2 0.6 0.4 -0.5 -0.8 0.1
Medication: Atorvastatin 0.4 0.5 2.2 -0.7 1.1 0.5 -0.4 0.1 0.8 -0.7 -0.5 -1.5 0.6 -0.5 -0.2 -0.2 -0.1 -1.1
Illnesses of father: High blood pressure 1.5 1.8 4.0 -1.0 -1.5 -2.0 -1.6 -1.4 -1.8 -1.6 1.5 -0.1 -0.6 -0.9 -1.3 -1.6 -0.9 -1.1
Alcohol drinker status: Never 2.4 2.9 11.4 -0.7 3.4 1.3 -0.1 2.1 2.6 -0.1 -1.5 -2.7 2.1 -1.0 -1.0 0.2 0.8 -1.3
Ever smoked 0.4 0.7 2.9 1.0 -1.7 -1.0 0.0 -1.4 -0.4 -0.2 1.1 0.8 -0.7 0.5 0.2 -0.4 -0.8 -0.0
Basal metabolic rate 1.5 8.6 41.9 -0.3 -5.4 0.2 -0.6 -3.0 -6.5 0.5 3.0 3.8 -1.1 2.8 1.3 -0.7 -2.9 1.9
Leg fat percentage (left) 0.7 2.6 9.3 0.4 -3.0 1.6 0.4 -1.6 -2.3 0.8 0.9 3.1 0.0 1.8 1.1 0.5 -0.9 1.9
Arm fat-free mass (left) 1.5 7.7 36.4 0.2 -5.2 0.3 -0.6 -2.8 -6.0 0.4 3.0 3.7 -0.9 2.6 1.3 -0.8 -2.8 1.8
Number of operations (self-reported) 2.0 2.9 12.3 1.3 -2.9 -0.9 -1.2 -2.2 -3.5 -1.2 2.0 0.9 -2.1 -0.0 -0.8 -1.2 -1.6 -0.2
Average weekly beer plus cider intake 1.9 2.8 9.9 1.9 -1.4 1.0 1.3 -0.3 -0.1 1.7 -0.4 3.1 -0.1 2.3 2.5 1.5 0.0 2.6
Irritability 0.3 0.4 1.5 1.2 -0.1 1.0 -0.1 0.6 0.6 0.5 0.8 -0.4 -0.6 0.4 0.5 -0.4 -1.2 0.0
Risk taking 0.5 0.8 3.2 0.3 0.9 0.1 0.8 0.7 0.4 0.4 -1.5 0.3 1.2 -0.0 -0.2 1.2 1.8 0.9
Ever had prostate specific antigen (PSA) test 2.3 2.7 7.4 -0.1 -2.1 -1.0 -1.5 -2.6 -1.3 -2.1 1.5 -0.1 -1.8 -1.8 -2.7 -1.4 -0.7 -1.1
Fractured/broken bones in last 5 years 0.7 0.9 2.5 0.9 1.6 -0.4 0.1 1.4 1.2 0.7 0.3 -1.3 -1.4 -0.4 -0.3 -0.1 -1.4 -0.4
Age started oral contraceptive pill 2.8 3.5 10.4 -0.3 1.4 1.2 2.4 0.8 1.2 1.5 -3.2 1.2 2.1 1.4 1.2 2.8 3.0 1.5
Diastolic blood pressure, automated reading 0.2 0.6 1.7 1.0 -0.3 0.4 1.0 0.2 0.9 0.6 -0.6 1.3 0.2 0.3 0.6 0.8 0.9 0.9
Ever depressed for a whole week 0.5 0.6 1.7 -0.5 0.9 -0.4 0.2 0.0 1.0 -0.6 -1.1 -0.7 0.4 -1.1 -1.3 0.2 1.0 -0.7
Unable to work because of sickness or disability 0.9 1.2 3.3 1.8 0.9 1.5 0.9 1.6 1.2 1.7 0.0 0.4 -0.3 1.0 0.9 0.5 -0.8 1.1
Commuting to job workplace: Cycle 6.7 8.1 14.6 -1.2 -0.5 -2.8 -3.3 -1.4 1.0 -3.3 2.9 -3.4 -2.8 -3.8 -3.7 -3.6 -2.4 -3.5
Myopia 1.1 1.6 4.2 -1.4 0.9 -0.1 1.6 0.3 0.9 0.7 -2.0 1.0 2.0 0.4 0.5 1.8 1.9 1.1
Vascular/heart problems diagnosed by doctor 0.1 0.3 0.9 -0.3 -0.2 -0.3 0.8 -0.2 -0.3 0.3 -0.7 0.9 0.3 0.2 0.2 0.8 0.8 0.9
Cholesterol lowering medication 0.1 0.2 0.9 -0.1 -0.1 0.4 0.2 0.4 -0.6 0.4 -0.0 0.2 1.0 0.6 -0.2 0.1 0.1 0.3
Medication: Omeprazole (e.g. Zanprol) 1.0 1.3 4.4 0.3 -0.6 -1.3 -0.9 -1.5 -1.9 -1.2 0.4 -0.1 -2.1 -1.1 -1.2 -0.5 -0.7 -0.6
Pain experienced in last month 0.3 0.5 1.7 -0.8 0.9 0.2 0.4 0.8 1.3 0.3 -0.5 -0.2 0.8 -0.1 1.0 0.3 1.1 0.2
Supplements: Calcium 0.3 0.3 1.0 0.8 0.7 0.8 -0.1 0.8 0.7 -0.1 0.3 -1.0 -0.1 -0.2 -0.1 -0.5 -0.3 -0.7
Basal cell carcinoma (self-reported) 0.4 0.4 1.2 -0.7 0.7 0.3 -0.6 0.8 1.1 0.0 0.2 -1.1 -0.4 -1.1 -0.2 -0.4 -0.1 -0.7
Heart attack/myocardial infarction (self-reported) 2.0 2.5 5.0 -0.3 -0.3 -0.9 -2.2 -0.3 -0.4 -1.3 2.2 -1.9 -1.7 -1.6 -1.9 -2.2 -2.0 -2.1
Deep venous thrombosis (DVT) (self-reported) 2.6 3.4 5.9 0.8 1.1 2.0 2.4 2.1 1.1 2.4 -1.4 1.2 2.4 2.3 2.1 1.8 1.2 2.0
Heart disease (siblings) 0.7 0.9 2.7 -1.5 -0.7 0.4 1.0 -0.7 -1.0 0.3 -0.8 1.6 -0.5 0.8 0.6 1.0 1.0 1.2
Alcohol drinker status: Previous 1.3 1.4 6.1 0.5 -0.5 -1.3 -1.4 -0.1 0.0 -0.2 1.7 -0.6 -2.5 -0.6 -0.1 -1.3 -2.4 -0.5
Pack years of smoking 0.8 1.1 3.8 0.1 -0.1 1.1 1.0 0.9 0.4 1.3 -0.5 1.1 1.9 1.5 1.0 1.1 0.6 1.4
Impedance of whole body 0.4 2.3 8.0 1.2 1.6 0.6 1.3 1.3 2.6 0.5 -2.2 -0.1 2.1 -0.0 0.0 1.5 2.8 0.4
Leg fat mass (left) 1.4 5.6 21.3 -0.0 -4.6 1.2 0.1 -2.4 -4.4 0.8 2.0 4.0 -0.7 2.3 1.1 0.1 -1.7 2.3
Arm predicted mass (left) 1.5 7.5 34.4 0.0 -5.1 0.3 -0.7 -2.9 -5.9 0.3 3.1 3.5 -1.4 2.4 1.2 -0.9 -2.8 1.7