[Hub]/) : Traits : Leg predicted mass (right) :

chr1:149,672,809-151,793,174

Best TWAS P=7.29e-10 · Best GWAS P=5.32e-16 conditioned to 9.43e-07

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex CTSS 0.04 0.01 bslmm 313 0.02 5.5e-04 -4.9 5.2 1.9e-07 0.13 0.03 0.92 TRUE
2 GTEx Artery Tibial HIST2H2AA3 0.22 0.02 enet 20 0.12 1.8e-09 7.5 5.6 2.0e-08 0.70 0.00 1.00 TRUE
3 GTEx Artery Tibial RP11-196G18.22 0.25 0.05 lasso 5 0.07 1.8e-06 2.4 5.3 9.2e-08 0.78 0.01 0.99 FALSE
4 GTEx Artery Tibial RP11-196G18.24 0.31 0.08 enet 26 0.10 6.1e-08 7.5 5.4 8.3e-08 0.72 0.00 0.99 FALSE
5 GTEx Ovary SEMA6C 0.29 0.13 enet 11 0.14 2.6e-04 -4.9 -5.1 2.7e-07 -0.22 0.01 0.92 FALSE
6 The Cancer Genome Atlas Breast Invasive Carcinoma C1orf54 0.06 0.02 enet 13 0.02 1.2e-05 5.0 -6.2 7.3e-10 -0.15 0.00 0.95 TRUE
7 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma C1orf54 0.04 0.04 lasso 2 0.03 2.0e-04 5.0 -5.1 2.7e-07 -0.10 0.00 0.98 FALSE
8 The Cancer Genome Atlas Brain Lower Grade Glioma MRPS21 0.13 0.13 enet 10 0.13 1.7e-14 -3.8 5.2 2.4e-07 0.07 0.13 0.73 FALSE