Best TWAS P=2.32e-13 · Best GWAS P=1.03e-13 conditioned to 0.0147
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | SHISA4 | 0.09 | 0.04 | lasso | 3 | 0.03 | 1.5e-03 | -5.9 | -6.3 | 2.7e-10 | -0.57 | 0.19 | 0.38 | FALSE |
| 2 | GTEx | Esophagus Muscularis | LMOD1 | 0.16 | 0.09 | enet | 9 | 0.08 | 7.8e-06 | 7.4 | -6.8 | 7.6e-12 | -0.98 | 0.01 | 0.99 | FALSE |
| 3 | GTEx | Esophagus Muscularis | RP11-307B6.3 | 0.20 | 0.12 | lasso | 3 | 0.12 | 5.6e-08 | 7.4 | -6.7 | 2.0e-11 | -0.97 | 0.01 | 0.99 | FALSE |
| 4 | METSIM | Adipose | LMOD1 | 0.09 | 0.07 | bslmm | 496 | 0.07 | 4.8e-10 | 7.3 | -7.0 | 3.5e-12 | -0.96 | 0.02 | 0.98 | FALSE |
| 5 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | LMOD1 | 0.07 | 0.06 | blup | 59 | 0.03 | 2.1e-02 | 7.3 | -6.4 | 1.6e-10 | -0.90 | 0.01 | 0.87 | FALSE |
| 6 | The Cancer Genome Atlas | Brain Lower Grade Glioma | LMOD1 | 0.04 | 0.07 | enet | 6 | 0.05 | 9.4e-07 | -6.2 | -6.8 | 7.6e-12 | -0.75 | 0.24 | 0.76 | FALSE |
| 7 | The Cancer Genome Atlas | Lung Adenocarcinoma | LMOD1 | 0.04 | 0.01 | blup | 59 | 0.01 | 5.7e-02 | 7.2 | -7.3 | 2.3e-13 | -0.83 | 0.01 | 0.82 | TRUE |