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chr3:51,860,817-53,860,103

Best TWAS P=1.66e-09 · Best GWAS P=2.81e-08 conditioned to 0.646

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	NT5DC2	0.11	0.05	enet	22	0.04	5.0e-06	3.5	-5.6	2.1e-08	-0.66	0.09	0.89	FALSE
2	GTEx	Prostate	RFT1	0.39	0.18	enet	17	0.24	1.1e-06	3.0	5.5	3.3e-08	0.49	0.15	0.75	TRUE
3	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	TMEM110	0.19	0.13	blup	59	0.13	4.2e-11	4.7	5.4	5.9e-08	0.58	0.04	0.95	FALSE
4	The Cancer Genome Atlas	Breast Invasive Carcinoma	GLT8D1	0.10	0.01	enet	7	0.03	4.4e-06	5.4	5.3	1.2e-07	0.67	0.00	0.95	FALSE
5	The Cancer Genome Atlas	Breast Invasive Carcinoma	TMEM110	0.13	0.09	lasso	3	0.10	5.9e-20	4.8	5.2	2.4e-07	0.62	0.06	0.93	FALSE
6	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	TMEM110	0.24	0.09	blup	59	0.14	1.4e-07	4.7	5.3	1.0e-07	0.59	0.02	0.96	FALSE
7	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	TMEM110	0.27	0.10	blup	59	0.14	3.0e-15	4.9	5.3	1.4e-07	0.61	0.01	0.99	FALSE
8	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	SPCS1	0.28	0.04	lasso	2	0.01	4.6e-02	5.4	5.1	2.7e-07	0.98	0.00	0.93	FALSE
9	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	TMEM110	0.21	0.10	lasso	4	0.08	2.3e-05	4.7	5.1	2.7e-07	0.54	0.04	0.96	FALSE
10	The Cancer Genome Atlas	Brain Lower Grade Glioma	GLT8D1	0.22	0.08	lasso	1	0.07	8.5e-09	5.4	5.4	8.0e-08	0.99	0.00	1.00	FALSE
11	The Cancer Genome Atlas	Brain Lower Grade Glioma	NISCH	0.06	0.05	lasso	4	0.04	7.5e-06	5.5	5.3	9.0e-08	0.96	0.00	1.00	FALSE
12	The Cancer Genome Atlas	Brain Lower Grade Glioma	SPCS1	0.15	0.03	lasso	3	0.04	4.3e-05	5.4	5.8	6.0e-09	0.95	0.00	0.95	FALSE
13	The Cancer Genome Atlas	Brain Lower Grade Glioma	TMEM110	0.13	0.06	blup	59	0.08	3.3e-09	3.8	5.5	4.1e-08	0.50	0.62	0.28	FALSE
14	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	RFT1	0.31	0.07	blup	45	0.19	1.8e-09	2.6	5.5	3.6e-08	0.48	0.02	0.97	FALSE
15	The Cancer Genome Atlas	Lung Adenocarcinoma	SPCS1	0.11	0.00	blup	41	0.01	9.9e-03	-3.2	6.0	1.7e-09	0.53	0.00	0.33	TRUE
16	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	TMEM110	0.19	0.10	lasso	5	0.11	2.1e-12	4.8	5.2	1.6e-07	0.45	0.05	0.94	FALSE
17	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	GLT8D1	0.20	0.05	lasso	1	0.04	1.0e-03	5.4	5.4	8.0e-08	0.99	0.00	0.96	FALSE
18	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	TMEM110	0.20	0.13	blup	59	0.15	3.0e-10	5.3	5.6	1.8e-08	0.61	0.01	0.99	FALSE
19	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	TMEM110	0.36	0.05	blup	59	0.08	3.4e-04	4.8	5.3	1.4e-07	0.56	0.02	0.61	FALSE
20	The Cancer Genome Atlas	Prostate Adenocarcinoma	TMEM110	0.20	0.06	blup	59	0.10	1.2e-10	5.3	5.8	8.1e-09	0.65	0.01	0.99	FALSE
21	The Cancer Genome Atlas	Soft Tissue Sarcoma	TMEM110	0.12	0.07	blup	59	0.12	7.5e-08	5.3	5.5	3.7e-08	0.52	0.02	0.98	FALSE
22	The Cancer Genome Atlas	Skin Cutaneous Melanoma	RFT1	0.29	0.04	blup	45	0.11	8.2e-04	4.7	5.2	2.0e-07	0.44	0.01	0.79	FALSE
23	The Cancer Genome Atlas	Stomach Adenocarcinoma	RFT1	0.13	0.05	blup	45	0.10	6.9e-08	5.0	5.4	8.0e-08	0.44	0.01	0.98	FALSE
24	The Cancer Genome Atlas	Stomach Adenocarcinoma	TMEM110	0.19	0.12	blup	59	0.13	1.6e-09	4.8	5.5	4.1e-08	0.61	0.05	0.94	FALSE
25	The Cancer Genome Atlas	Testicular Germ Cell Tumors	TMEM110	0.20	0.01	lasso	2	0.09	3.2e-04	5.3	5.4	6.9e-08	0.56	0.01	0.82	FALSE
26	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	RFT1	0.29	0.15	blup	45	0.15	6.5e-05	4.1	5.5	4.0e-08	0.43	0.01	0.80	FALSE