Hub : Genes

SPCS1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.2210	0.0850	6.4e-04	0.031	NA	0.001	NA	0.007	2.2e-03	NA	2.4e-01	NA	9.4e-02
2	GTEx	Esophagus Gastroesophageal Junction	0.1310	0.0640	1.6e-03	0.002	NA	-0.004	NA	0.000	2.6e-01	NA	4.6e-01	NA	3.1e-01
3	GTEx	Whole Blood	0.0280	0.0130	8.2e-04	0.021	NA	0.012	NA	0.021	4.1e-03	NA	2.3e-02	NA	4.5e-03
4	ROSMAP	Brain Pre-frontal Cortex	0.0355	0.0174	2.3e-05	0.033	0.040	0.016	0.038	0.031	3.5e-05	6.6e-06	2.8e-03	9.9e-06	6.3e-05
5	YFS	Blood	0.0377	0.0136	7.4e-13	0.030	0.036	0.036	0.036	0.036	2.6e-10	6.4e-12	6.0e-12	8.5e-12	7.4e-12
6	TCGA	Breast Invasive Carcinoma	0.0842	0.0376	5.9e-07	0.038	0.035	0.035	NA	0.036	2.4e-08	7.8e-08	8.4e-08	NA	4.7e-08
7	TCGA	Kidney Renal Papillary Cell Carcinoma	0.2790	0.1230	7.7e-03	0.038	0.001	0.010	NA	0.015	3.1e-03	2.8e-01	8.2e-02	NA	4.6e-02
8	TCGA	Brain Lower Grade Glioma	0.1512	0.0698	1.9e-03	0.033	0.029	0.030	NA	0.037	9.6e-05	2.4e-04	1.9e-04	NA	4.3e-05
9	TCGA	Lung Adenocarcinoma	0.1079	0.0566	3.1e-03	0.002	0.013	0.013	NA	0.003	1.9e-01	9.9e-03	1.1e-02	NA	1.4e-01
10	TCGA	Lung Squamous Cell Carcinoma	0.0429	0.0346	5.1e-03	0.030	0.012	0.029	NA	0.006	2.4e-04	1.5e-02	2.9e-04	NA	6.2e-02
11	TCGA	Ovarian Serous Cystadenocarcinoma	0.2820	0.1130	9.6e-05	0.079	0.044	0.028	NA	0.069	4.8e-06	5.6e-04	5.5e-03	NA	1.9e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Bipolar Disorder (2018)	6.8	10.8	21.5	-4.1	3.3	-3.5	-4.3	-2.7	-4.5	-0.8	-1.8	-2.2	-4.6	-1.8
Bipolar Disorder or Schizophrenia	9.8	23.9	44.3	-5.8	4.8	-5.8	-6.2	-4.0	-6.6	-1.7	-2.7	-3.7	-6.7	-2.6
Depressed Affect (Nagel 2018)	2.2	4.5	10.4	-1.5	0.2	-2.2	-2.1	-2.8	0.1	3.2	3.0	1.9	-0.4	2.8
Depression (Nagel 2018)	2.8	4.2	9.0	-2.7	1.5	-2.5	-2.4	-2.3	-2.8	0.2	-0.4	-1.2	-3.0	-0.8
Intelligence (Savage-Jansen 2018)	6.7	20.6	36.1	5.9	-4.8	6.0	6.0	5.3	5.5	-0.9	0.1	1.5	5.9	0.3
Neuroticism (Nagel 2018)	4.2	10.0	21.0	-3.9	2.5	-4.6	-4.5	-4.2	-3.5	1.0	0.4	-1.1	-3.8	0.6
Schizophrenia (2018)	6.4	13.3	23.6	-4.2	3.5	-4.6	-4.4	-3.0	-4.9	-1.6	-2.0	-3.1	-4.8	-2.0
Schizophrenia vs Biploar Disorder	0.7	0.9	3.4	-0.0	-0.4	-0.4	0.5	-0.3	1.4	0.0	0.9	-0.9	1.4	1.8
Worry (Nagel 2018)	10.9	23.0	39.9	-5.7	4.5	-6.3	-5.8	-5.2	-6.2	-1.2	-2.0	-3.7	-6.3	-1.6
Alzheimer’s Disease (in mother)	0.4	0.5	1.0	-0.8	0.7	0.0	-0.9	-0.7	-0.9	0.6	-0.2	0.5	-1.0	-0.3
Alzheimer’s Disease (in father)	1.1	1.2	3.2	-1.1	-1.4	-1.0	-0.3	-1.4	0.5	1.3	1.5	-0.2	0.3	1.8
Alzheimer’s Disease (including proxy)	0.7	1.0	3.1	-1.4	-0.5	-0.8	-1.1	-1.8	-0.5	1.2	0.7	0.0	-0.7	0.8
Crohns Disease (2017)	0.2	0.5	2.2	-0.1	-0.9	-1.5	-0.8	-0.8	-0.4	0.1	0.4	-0.8	-0.5	0.3
Irritable Bowel Disease (IBD)	0.6	1.5	4.5	-0.9	0.5	-2.1	-1.5	-1.3	-1.5	-0.1	0.0	-0.8	-1.6	-1.2
Ulcerative Colitis (UC)	0.8	1.4	2.8	-1.0	1.1	-1.7	-1.2	-1.1	-1.5	0.0	-0.0	-0.3	-1.6	-1.6
Major Depression (MDD)	3.3	4.1	9.2	-2.5	1.3	-3.0	-2.6	-2.2	-2.6	0.0	0.0	-0.9	-2.8	0.1
Reaction Time	0.1	0.3	0.8	-0.4	-0.1	-0.6	-0.0	-0.7	-0.0	0.6	0.9	-0.8	-0.1	-0.1
Verbal and Numeric Reasoning (VNR)	6.5	15.6	29.5	4.5	-4.8	5.3	4.9	3.8	5.2	0.1	0.8	1.6	5.4	1.2
Breast Cancer	0.8	2.0	6.1	1.1	-1.4	2.5	1.1	1.4	1.9	1.0	0.5	0.7	1.8	1.0
Ovarian Cancer	0.8	1.1	2.9	-0.9	1.7	0.5	-0.6	0.4	-1.1	-0.7	-1.5	-1.4	-1.1	-0.4
Prostate Cancer	0.7	1.0	3.5	-1.1	0.7	-1.9	-1.3	-1.4	-0.6	0.7	0.0	-0.7	-0.7	0.0
Age at First Birth	3.3	4.7	11.0	2.9	-3.3	1.2	3.1	1.6	2.7	0.6	0.0	1.9	2.8	0.0
Bipolar Disorder (2011)	8.3	8.0	23.6	-4.7	2.4	-4.6	-4.9	-3.9	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.9	1.3	3.1	1.5	-0.9	1.8	1.1	0.6	1.4	0.7	0.0	1.1	1.4	0.0
Coronary Artery Disease (CAD)	0.4	0.5	2.6	0.8	0.7	0.6	0.4	0.3	0.5	-0.3	0.0	1.6	0.6	0.0
Crohns Disease (2012)	0.2	0.4	1.3	-0.3	-0.2	-1.1	-0.9	-0.7	-0.5	-0.0	0.1	-0.8	-0.5	0.2
Mean Putamen Volume	0.6	0.7	1.8	-1.3	0.2	-1.0	-0.7	-1.4	-0.8	0.3	-0.1	-0.7	-0.9	0.3
Fasting Glucose	0.9	1.1	3.2	0.9	1.7	1.0	-0.1	1.7	-0.9	-1.8	0.0	0.1	-0.7	0.0
HbA1C	0.4	0.4	2.5	-0.2	-0.0	-0.3	0.7	-0.8	-0.8	-1.6	0.0	-0.4	-0.5	0.0
HDL Cholesterol	3.8	6.3	21.9	-0.8	-4.5	-1.0	-0.9	-2.0	3.3	4.7	0.0	1.8	2.6	0.0
LDL Cholesterol	3.7	5.8	13.8	3.1	-0.0	3.7	3.5	3.6	0.5	-3.7	0.0	-0.3	1.1	0.0
Lupus	0.1	0.2	0.6	0.4	-0.1	-0.2	0.1	0.5	0.5	0.4	0.4	-0.4	0.5	0.8
Neuroticism (2016)	2.4	3.5	8.0	-2.0	1.0	-2.8	-2.7	-2.8	-2.1	0.4	0.4	-1.0	-2.3	0.2
Primary Biliary Cirrhosis	1.5	2.1	5.3	1.8	-1.4	1.8	2.3	1.9	1.5	-0.9	-0.4	0.3	1.7	-0.2
Rheumatoid Arthritis	1.6	2.2	6.9	1.3	-2.6	1.3	2.3	0.3	1.9	-0.1	0.5	0.9	2.0	0.8
Schizophrenia (2014)	8.0	17.8	31.9	-4.8	4.4	-5.0	-5.0	-3.0	-5.7	-2.0	-2.5	-3.8	-5.6	-2.4
Triglycerides	2.8	4.6	15.8	0.3	4.0	0.9	-0.2	1.6	-3.1	-3.5	0.0	-1.4	-2.7	0.0
Type 2 Diabetes (T2D) (2012)	2.0	2.3	8.8	-1.9	3.0	-0.5	-0.3	-0.8	-2.3	-1.3	0.0	-1.0	-2.1	0.0
Ulcerative Colitis	2.2	3.2	7.3	-2.1	1.4	-2.7	-2.3	-2.5	-2.0	0.4	0.2	-0.4	-2.2	-0.7
Blood Eosinophil Count	1.5	11.7	35.4	4.2	-1.5	4.7	6.0	3.6	3.3	-0.6	0.1	3.6	3.6	-1.4
Blood Platelet Count	1.5	17.1	37.0	6.1	-2.8	5.1	5.2	6.1	4.4	-2.2	-1.6	1.1	5.0	-0.6
Blood Red Count	5.3	50.8	99.8	-7.2	8.2	-7.4	-7.5	-5.2	-10.0	-3.7	-5.1	-6.9	-9.9	-4.0
Blood White Count	1.2	9.1	23.3	0.9	3.8	3.3	1.3	3.3	-1.9	-3.9	-4.8	-0.9	-1.3	-4.0
Heel T-Score	0.5	3.7	13.2	1.5	-0.4	2.5	3.6	1.3	1.6	-2.4	-1.9	-0.5	2.0	1.1
BMI	6.1	35.5	68.6	6.1	-4.1	7.3	5.6	4.1	8.3	3.7	4.3	7.0	8.1	4.5
Height	4.1	78.8	187.7	-11.4	-1.2	-12.8	-10.7	-13.7	-4.9	8.8	8.6	1.0	-6.6	7.0
Waist Hip Ratio (WHR)	15.0	67.6	139.2	-6.8	11.8	-4.7	-5.8	-2.1	-11.5	-6.6	-8.2	-8.6	-11.0	-7.8
Systolic Blood Pressure	1.7	8.4	18.9	4.2	-2.5	2.9	4.3	3.5	3.0	-1.9	-0.7	2.2	3.4	-1.2
Smoking Status	5.0	11.9	31.7	4.3	-0.6	5.6	4.4	4.8	3.7	-0.8	-0.6	2.3	4.0	-0.9
Allergy or Eczema	0.6	1.6	4.2	-1.5	0.5	-0.4	-1.1	-0.9	-2.1	-0.8	-1.2	-1.2	-2.0	-1.2
Cardiovascular Disease	1.4	4.7	10.3	2.5	-1.4	3.1	3.2	2.1	2.8	-0.8	-0.1	1.4	3.0	0.5
Hypothyroidism (self reported)	0.6	1.3	4.7	0.4	-1.8	0.2	0.4	0.3	1.6	0.4	0.7	-0.5	1.6	2.2
Respiratory disease	0.6	1.3	2.9	-1.7	0.5	-0.9	-1.0	-1.5	-0.7	1.7	1.6	0.6	-1.0	0.1
Type 2 Diabetes (T2D) (2018)	1.4	2.7	9.6	1.4	0.1	3.1	2.3	1.9	1.8	-0.7	-0.8	0.8	2.0	-0.0
Lung FEV1/FVC ratio	2.2	11.3	22.8	4.8	-4.4	2.9	4.2	2.8	4.5	0.4	1.0	1.5	4.7	1.4
Lung FVC	1.3	6.8	17.4	3.7	-1.6	1.5	4.2	2.9	1.4	-3.3	-2.0	0.2	2.0	-3.0
Neuroticism	4.9	11.8	25.0	-4.4	2.9	-4.6	-5.0	-4.4	-3.7	1.5	0.6	-1.6	-4.1	0.8
Chronotype (morning person)	1.2	2.8	8.1	2.1	1.6	2.1	1.6	1.8	0.5	-1.3	-1.1	2.9	0.7	-1.6
Hair Pigment	0.0	0.1	0.5	-0.2	-0.0	0.7	0.3	-0.1	-0.2	0.3	0.2	0.4	-0.3	-0.3
Tanning	1.1	12.8	25.1	4.1	-3.7	4.2	4.3	2.7	4.9	1.0	1.8	3.1	5.0	1.8
Hand grip strength (left)	2.0	5.2	14.9	-2.9	0.1	-2.2	-3.9	-2.7	-0.6	2.5	1.7	0.4	-1.1	3.3
Number of treatments/medications taken	1.5	2.8	5.7	2.4	0.5	2.3	1.9	2.2	1.8	-0.8	-0.6	1.5	2.0	-0.4
Average weekly spirits intake	2.5	3.0	5.8	1.4	-1.6	1.7	1.4	1.3	2.4	1.4	1.8	1.7	2.3	1.6
Sensitivity / hurt feelings	1.1	1.9	3.7	-1.9	1.3	-1.2	-1.6	-0.8	-1.8	-0.6	-1.3	-1.5	-1.7	-0.3
Frequency of depressed mood in last 2 weeks	2.0	2.8	5.8	-2.4	1.3	-2.2	-2.0	-2.4	-1.9	0.9	0.6	0.1	-2.1	-0.2
Hearing difficulty/problems: Yes	0.3	0.4	1.6	0.2	0.4	-0.1	1.3	0.5	-0.5	-0.9	-0.5	0.9	-0.4	-0.8
Relative age of first facial hair	0.1	0.1	0.5	-0.1	-0.7	-0.2	0.4	0.2	0.4	-0.0	0.1	-0.5	0.5	0.5
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	1.2	-0.2	0.9	-0.4	-0.6	0.1	-1.0	-0.5	-1.0	-1.1	-1.0	-0.4
Ever used hormone-replacement therapy (HRT)	3.6	4.6	11.6	1.1	3.4	1.6	0.4	2.1	-1.3	-2.8	-2.9	-0.7	-0.9	-3.4
Ever had hysterectomy (womb removed)	1.8	2.0	5.4	1.2	1.6	1.0	0.8	1.9	-0.7	-1.8	-1.6	-0.9	-0.5	-2.3
Systolic blood pressure, automated reading	2.3	6.8	14.1	3.8	-2.5	1.9	3.6	2.6	3.0	-0.7	0.6	3.3	3.2	-0.1
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	0.9	0.6	0.1	0.8	0.9	0.7	0.3	-0.9	-0.7	0.0	0.5	-0.6
Angina	0.6	0.8	2.0	0.7	-0.9	0.3	0.7	0.4	1.4	0.8	1.2	1.0	1.3	0.5
Medication for hormone replacement therapy	2.6	2.9	6.9	0.8	2.3	1.1	0.3	1.6	-1.3	-2.4	-2.6	-1.2	-1.0	-2.3
Vitamin and mineral supplements	1.6	2.2	4.4	-1.4	1.6	-0.8	-0.9	-0.9	-2.1	-1.5	-1.7	-1.2	-2.0	-1.6
Supplements: Zinc	0.3	0.3	0.9	0.4	0.8	0.5	0.7	0.4	0.4	0.2	0.3	1.0	0.4	0.0
Medication: Co-codamol	1.0	1.2	3.5	0.2	1.2	0.2	0.4	1.0	-0.7	-1.9	-1.6	-1.7	-0.5	-0.9
Medication: Metformin	0.9	1.2	3.0	1.1	-0.9	1.5	1.3	0.7	1.7	0.2	0.3	0.9	1.7	0.7
Diabetes (father)	0.5	0.6	1.2	0.3	1.0	1.0	0.4	1.0	-0.2	-0.9	-0.9	-1.1	-0.1	-0.8
Diabetes (mother)	1.1	1.4	3.8	-1.6	1.4	0.1	-0.7	-0.0	-1.3	-0.9	-1.5	-1.9	-1.2	-0.6
Severe depression (siblings)	1.1	1.2	4.3	-0.9	1.5	-0.5	-1.1	-0.3	-1.2	-0.5	-0.9	-2.1	-1.2	-0.6
Pack years adult smoking proportion	2.2	3.3	7.5	-0.9	2.7	-1.0	-0.6	-0.8	-2.5	-1.9	-1.9	-0.9	-2.3	-2.6
Impedance of leg (right)	6.7	32.5	65.1	-5.5	5.2	-4.8	-5.0	-2.9	-7.8	-4.1	-5.5	-8.1	-7.5	-3.9
Leg fat-free mass (left)	2.8	14.6	36.5	1.1	-3.2	0.8	0.8	-1.2	4.2	5.2	5.8	6.0	3.5	4.4
Trunk fat percentage	0.1	0.6	1.3	-1.0	0.9	-0.1	-1.1	-0.9	-0.9	0.2	-0.1	-0.5	-1.1	-0.2
Hand grip strength (right)	2.2	6.0	18.0	-2.8	-1.6	-2.0	-3.4	-3.0	0.3	2.9	2.1	0.5	-0.2	4.2
Townsend deprivation index at recruitment	0.8	1.1	3.1	0.4	-0.3	1.6	1.7	0.2	1.2	0.3	0.6	1.7	1.2	-0.2
Current tobacco smoking	1.1	1.7	4.9	1.6	0.0	2.2	1.8	1.9	0.8	-0.8	-0.8	0.5	1.0	-1.4
Average weekly fortified wine intake	2.2	2.5	6.7	-1.2	-1.4	-1.4	-1.6	-2.1	0.3	2.3	1.9	-0.0	-0.1	2.6
Maternal smoking around birth	1.2	1.8	4.1	-0.7	1.7	-0.1	0.0	-0.1	-1.6	-1.6	-1.7	-1.4	-1.4	-2.0
Fed-up feelings	1.0	1.9	4.5	-0.6	0.8	-0.7	-0.9	-1.3	0.5	2.1	1.9	2.0	0.2	1.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	1.0	2.2	-1.3	0.4	-1.5	-1.0	-1.3	-1.2	0.7	0.5	0.6	-1.3	-0.1
Relative age voice broke	2.3	3.5	7.7	2.0	-1.7	2.3	2.4	2.3	2.6	-0.1	0.3	0.2	2.8	0.7
Taking other prescription medications	0.2	0.2	0.8	-0.1	0.7	0.2	0.4	0.1	0.2	-0.5	-0.7	-0.9	0.3	0.4
Age when periods started (menarche)	7.8	18.7	47.9	3.8	-6.9	1.7	3.7	0.8	6.0	3.2	4.4	3.2	5.8	4.0
Bilateral oophorectomy (both ovaries removed)	2.4	2.7	10.0	1.0	3.2	0.7	-0.3	2.0	-1.2	-1.8	-1.8	-1.2	-1.0	-2.0
Heel bone mineral density (BMD) T-score, automated (left)	1.1	2.5	6.2	2.5	0.3	1.7	2.4	2.0	1.2	-1.7	-1.3	-0.1	1.5	-0.5
Tinnitus: Yes, but not now, but have in the past	0.5	0.6	1.3	-0.2	0.6	-1.1	-0.4	-0.8	-1.1	-0.1	-0.1	0.7	-1.1	-0.9
Qualifications: CSEs or equivalent	0.9	1.2	2.7	-1.6	0.2	-0.8	-1.6	-1.6	-1.1	1.1	0.6	0.4	-1.3	0.3
Serious illness, injury or assault to yourself	1.7	2.0	7.4	-0.5	2.7	-0.4	-1.0	0.4	-1.7	-1.5	-1.7	-1.3	-1.6	-1.1
High blood pressure	1.3	3.6	8.4	2.3	-2.1	1.7	2.5	1.6	2.7	-0.4	0.5	1.3	2.9	0.7
Hayfever, allergic rhinitis or eczema	1.5	3.2	8.1	-1.8	1.6	-1.0	-1.7	-1.1	-2.9	-1.1	-1.5	-1.2	-2.8	-1.7
Multivitamins +/- minerals	2.5	3.2	6.1	1.9	-1.9	1.8	1.7	1.3	2.5	1.3	1.6	1.6	2.4	1.3
Stomach or abdominal pain in last month	2.9	3.7	8.2	-1.8	2.9	-2.2	-2.2	-0.8	-2.6	-1.1	-1.1	-1.5	-2.6	-0.8
Supplements: Glucosamine	0.4	0.6	1.2	1.1	0.3	0.3	1.1	0.9	0.8	-0.5	0.1	1.0	0.9	0.2
Diverticular disease/diverticulitis (self-reported)	1.4	1.7	5.0	0.2	1.2	0.3	0.4	0.5	-1.4	-1.9	-2.2	-1.2	-1.1	-1.9
Medication: Atenolol	1.1	1.4	2.7	1.6	-0.2	1.6	1.3	1.3	0.8	-1.3	-1.4	-0.5	1.1	-0.7
Medication: Levothyroxine sodium	1.1	1.9	6.7	1.0	-2.6	0.3	1.0	0.2	1.9	0.7	1.1	-0.3	1.8	1.9
Sitting height	3.4	23.9	48.6	-4.9	-1.1	-6.4	-5.7	-7.0	-1.8	6.2	6.1	3.6	-2.9	3.9
Chronic bronchitis/emphysema (father)	0.3	0.3	0.9	-1.0	-0.7	-0.6	0.0	-0.9	-0.4	0.0	-0.0	-0.5	-0.5	-0.5
High blood pressure (mother)	1.1	1.5	7.3	-0.7	2.7	-0.3	-1.5	0.0	-1.4	-0.8	-1.3	-0.2	-1.3	-0.7
Body mass index (BMI)	3.5	14.8	27.4	4.8	-2.0	5.2	4.3	3.7	5.0	0.8	1.5	4.5	5.1	1.3
Impedance of leg (left)	7.4	35.9	69.2	-5.9	5.6	-5.3	-5.3	-3.1	-8.3	-4.1	-5.5	-8.1	-8.1	-4.2
Leg predicted mass (left)	2.8	14.7	35.9	1.1	-3.2	0.8	0.7	-1.2	4.2	5.2	5.8	6.0	3.5	4.5
Trunk fat mass	0.3	1.2	3.6	-0.5	-0.3	-0.0	-0.8	-1.2	0.5	1.9	1.8	1.5	0.2	1.4
Waist circumference	0.4	1.3	4.7	0.2	2.2	0.9	0.2	0.8	-1.0	-1.3	-1.3	-0.2	-0.9	-1.7
Number of incorrect matches in round	2.7	4.5	12.7	-2.2	1.1	-3.4	-3.6	-2.5	-2.1	0.5	0.5	-1.6	-2.3	-0.4
Past tobacco smoking	3.4	6.3	15.3	-2.7	1.4	-3.9	-3.1	-3.0	-3.3	-0.3	-0.4	-1.6	-3.4	-0.6
Alcohol usually taken with meals	1.0	1.6	4.5	-1.5	1.2	-1.0	-2.1	-0.6	-1.3	-0.2	-1.0	-1.8	-1.3	0.5
Nervous feelings	7.4	13.9	25.3	-4.9	3.2	-4.8	-4.6	-3.9	-4.9	-0.4	-1.1	-2.5	-5.0	-1.3
Frequency of tenseness / restlessness in last 2 weeks	3.1	4.8	9.7	-2.5	2.5	-2.8	-3.1	-3.1	-2.3	1.1	0.4	0.0	-2.5	0.5
Hearing difficulty/problems with background noise	1.1	1.8	4.8	-1.2	1.3	-1.8	-0.9	-0.8	-2.2	-0.5	-0.4	-0.4	-2.2	-1.3
Hair/balding pattern: Pattern 2	2.6	3.2	10.7	-0.2	-0.8	0.2	-0.0	-0.5	2.4	2.5	2.6	0.7	2.1	3.3
Had menopause	0.7	0.8	1.7	1.3	-0.7	0.8	1.3	1.1	0.8	-0.9	-0.6	-0.1	1.0	-0.7
Had other major operations	0.6	0.7	1.6	0.6	1.0	1.3	0.1	0.9	-0.2	-0.9	-1.2	-1.2	-0.1	-0.9
Forced vital capacity (FVC)	1.0	3.8	11.6	-2.1	0.1	-3.4	-2.2	-3.1	-1.4	1.5	1.7	1.1	-1.7	0.6
Heel bone mineral density (BMD) T-score, automated (right)	1.2	2.8	6.2	2.2	0.8	1.6	2.5	2.4	1.0	-2.1	-1.6	-0.4	1.4	-0.7
Ever unenthusiastic/disinterested for a whole week	0.9	1.0	2.5	0.5	1.2	0.6	0.2	0.6	-0.8	-1.4	-1.6	-1.3	-0.6	-1.3
Qualifications: None of the above	1.0	2.2	9.5	0.6	-0.7	-0.1	1.2	-0.6	1.4	1.7	2.4	3.1	1.2	0.4
Financial difficulties in last 2 years	0.2	0.3	1.5	0.0	1.2	0.6	0.2	0.4	-0.1	-0.2	-0.5	-0.7	-0.1	-0.2
Mouth/teeth dental problems	0.6	1.0	2.6	1.1	-0.7	0.9	0.5	0.8	1.5	0.0	0.2	0.6	1.6	1.4
Heart attack	1.1	1.4	3.8	1.2	-1.0	1.9	1.4	1.3	1.1	-0.7	-1.2	-0.4	1.3	-0.2
Allergy	1.9	4.4	10.6	2.7	-1.7	1.8	2.3	2.2	3.1	0.1	0.5	1.3	3.3	1.6
Pain all over the body in last month	1.0	1.1	2.5	-0.8	1.4	-0.4	-1.1	-0.8	-1.5	-0.1	-0.5	-1.3	-1.6	-0.7
Diabetes (self-reported)	2.0	3.1	7.5	2.2	-1.0	2.7	2.7	1.8	2.0	-0.6	-0.4	1.2	2.1	-0.3
Hayfever/allergic rhinitis (self-reported)	1.4	1.8	3.7	-1.3	0.8	-1.2	-1.1	-1.0	-1.9	-1.3	-1.6	-1.2	-1.8	-1.3
Medication: Ramipril	0.6	0.8	1.4	0.6	-1.2	1.0	1.2	0.3	1.2	0.3	0.2	0.7	1.2	1.0
Medication: Simvastatin	0.3	0.4	1.5	0.7	-0.3	1.0	0.4	0.2	0.8	0.2	0.1	1.2	0.9	0.0
Fluid intelligence score	3.5	7.3	15.0	3.0	-3.6	3.9	3.5	2.8	3.3	0.1	0.4	0.4	3.4	0.8
Illnesses of siblings	0.2	0.3	0.4	0.6	0.5	0.3	-0.3	0.6	-0.6	-0.4	-0.7	-0.7	-0.5	0.1
Neuroticism score	2.6	5.3	10.5	-3.0	1.9	-3.0	-3.2	-3.2	-2.0	1.9	1.1	0.0	-2.4	1.3
Weight	1.7	8.2	22.8	1.2	-2.2	1.2	0.8	-0.5	3.2	3.6	4.1	4.8	2.8	3.3
Impedance of arm (right)	7.9	36.8	68.2	-7.8	4.2	-6.7	-6.6	-5.5	-8.1	-1.8	-3.1	-7.4	-8.3	-2.7
Arm fat percentage (right)	0.6	2.3	6.9	1.5	-0.2	2.6	1.4	1.4	2.0	0.6	0.7	1.7	1.9	0.8
Trunk fat-free mass	2.9	16.8	39.7	0.9	-3.9	-0.2	0.7	-1.7	4.3	5.4	6.3	6.3	3.6	5.0
Hip circumference	2.0	8.6	15.5	2.8	-3.3	2.3	2.0	1.3	3.9	2.3	3.1	3.9	3.7	2.4
Time employed in main current job	0.9	1.1	2.6	0.1	0.9	1.5	0.6	1.5	-0.3	-1.4	-1.6	-0.3	-0.1	-1.2
Alcohol intake versus 10 years previously	1.9	2.8	6.3	2.0	-2.5	1.4	2.5	1.1	2.0	0.2	0.8	1.5	2.0	0.5
Father’s age at death	0.3	0.4	1.0	-0.8	0.0	-0.4	-1.0	-0.9	-0.7	0.8	0.3	0.4	-0.8	-0.1
Worrier / anxious feelings	6.3	11.9	22.7	-3.6	3.4	-4.8	-4.6	-3.3	-4.2	-1.0	-1.8	-3.5	-4.2	-0.6
Frequency of tiredness / lethargy in last 2 weeks	1.3	2.1	6.6	-1.1	2.6	-1.8	-1.7	-1.2	-1.8	0.1	-0.0	-0.5	-1.9	-0.5
Falls in the last year	2.1	2.9	8.1	0.6	1.8	1.0	0.8	1.5	-1.6	-2.4	-2.5	-0.1	-1.3	-2.9
Hair/balding pattern: Pattern 3	0.6	0.9	2.2	1.0	-0.2	1.5	1.1	1.5	0.3	-1.1	-1.0	-0.2	0.4	-0.9
Number of live births	0.7	1.0	3.0	0.1	-0.4	0.8	0.8	0.4	-0.1	-1.7	-1.6	-1.5	0.1	-1.1
Forced expiratory volume in 1-second (FEV1)	0.4	1.4	4.2	-0.5	-0.8	-2.0	-0.8	-1.8	-0.2	1.2	1.5	1.3	-0.4	0.5
Pulse rate	5.4	9.2	18.9	-2.9	4.3	-2.6	-3.3	-1.4	-4.4	-1.5	-2.2	-2.4	-4.3	-2.1
Happiness	3.8	4.6	10.6	-2.7	-0.0	-2.9	-3.0	-3.2	-1.0	2.2	1.9	-0.5	-1.4	2.1
Noisy workplace	0.3	0.4	1.1	0.8	-1.0	0.6	0.9	0.9	0.5	0.1	0.1	0.4	0.5	-0.1
Qualifications: A levels/AS levels or equivalent	0.6	1.2	4.5	1.4	-2.1	0.9	0.4	0.3	1.4	0.8	0.5	0.0	1.4	1.1
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	2.6	-0.6	1.6	-0.9	-1.5	-0.3	-1.1	-0.2	-0.5	-1.2	-1.1	-0.1
Mouth/teeth dental problems: Dentures	0.5	0.8	4.3	0.1	-0.3	0.2	0.8	-0.2	0.7	1.1	1.2	2.1	0.6	-0.1
Asthma	0.1	0.2	0.5	-0.7	0.7	0.0	-0.1	-0.2	-0.2	0.5	0.6	-0.1	-0.3	-0.3
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	4.2	0.2	0.1	0.7	-0.4	-0.1	1.0	1.4	1.1	2.0	0.8	0.7
Medication: Cholesterol lowering	2.0	3.0	7.1	2.0	-1.8	2.0	1.8	1.3	2.6	0.4	0.7	1.2	2.7	1.0
Depression (self-reported)	1.9	2.3	4.8	-2.1	1.5	-1.9	-2.2	-2.2	-0.6	1.0	0.4	-0.8	-0.7	1.8
Medication: Lansoprazole	0.9	1.0	4.6	-0.3	2.1	-0.0	-0.8	0.5	-0.8	-1.0	-1.4	-1.1	-0.7	-0.5
Prospective memory result	4.8	5.8	13.4	-3.1	2.0	-3.7	-3.1	-3.0	-2.9	0.7	0.5	-0.5	-3.1	-0.2
Lung cancer (father)	0.1	0.2	0.4	-0.1	0.3	-0.5	-0.7	-0.4	-0.5	-0.3	-0.4	-0.1	-0.5	-0.1
Illnesses of mother	1.0	1.3	4.3	1.2	-2.1	1.1	1.6	1.0	1.3	0.2	0.4	0.0	1.3	0.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.9	4.5	-0.2	-0.7	-2.1	-0.7	-1.4	-0.2	0.6	1.0	0.8	-0.3	0.4
Pulse wave Arterial Stiffness index	1.0	1.1	3.3	1.8	0.2	1.1	1.1	1.8	0.3	-0.7	-0.7	1.0	0.5	-0.9
Impedance of arm (left)	8.2	38.1	71.4	-8.0	4.3	-6.8	-6.8	-5.6	-8.3	-1.6	-3.1	-7.4	-8.4	-2.8
Arm fat mass (right)	1.0	4.1	9.9	1.7	-1.1	2.3	1.5	0.8	2.7	1.6	2.0	3.1	2.5	1.8
Trunk predicted mass	3.0	17.2	40.3	1.0	-4.0	-0.1	0.7	-1.7	4.4	5.5	6.3	6.3	3.7	5.2
Standing height	3.6	35.8	79.6	-7.5	-0.6	-8.5	-7.4	-8.9	-3.5	6.4	5.9	1.0	-4.7	4.4
Length of working week for main job	1.8	2.0	5.6	-0.1	-1.2	0.2	0.5	-0.8	1.7	2.0	2.4	1.2	1.4	2.0
Exposure to tobacco smoke at home	0.7	0.8	2.1	-1.1	-0.8	-0.6	-1.1	-0.7	0.3	1.1	1.1	-0.5	0.1	1.4
Breastfed as a baby	1.3	1.6	6.9	1.1	-2.6	0.8	1.3	0.2	1.5	0.7	1.2	0.8	1.5	0.5
Tense / ‘highly strung’	3.2	5.3	10.7	-3.1	1.6	-2.9	-3.2	-3.3	-2.4	0.3	-0.3	-1.6	-2.6	0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	3.1	4.7	11.8	-2.7	2.3	-2.4	-3.4	-2.1	-2.7	0.4	-0.5	-1.1	-2.9	-0.4
Hair/balding pattern: Pattern 4	0.9	2.2	5.8	2.4	-0.9	2.4	1.6	1.2	1.8	0.3	0.0	0.9	1.8	0.6
Birth weight of first child	0.6	1.1	3.3	-1.8	-0.1	-1.1	-1.3	-1.2	-1.1	0.3	-0.0	-1.4	-1.2	0.2
Peak expiratory flow (PEF)	0.9	2.1	5.8	-0.4	-1.0	-0.9	-0.6	-1.6	0.7	2.4	2.2	2.1	0.4	1.6
Pulse wave reflection index	3.1	3.8	7.4	2.4	-1.9	2.2	2.0	1.2	2.7	1.0	1.2	1.9	2.7	1.3
Ever highly irritable/argumentative for 2 days	3.8	4.5	10.0	3.0	-1.3	3.2	2.8	2.5	2.4	0.4	0.3	1.5	2.5	0.5
Loud music exposure frequency	0.5	0.6	1.7	-1.0	-0.0	-1.0	-0.5	-0.3	-0.7	-0.5	-0.4	-1.3	-0.7	-1.0
Qualifications: O levels/GCSEs or equivalent	0.6	0.9	2.7	-1.0	0.2	-0.3	-1.7	-1.0	-0.5	1.2	0.1	-0.9	-0.7	1.3
Mouth/teeth dental problems: Bleeding gums	5.3	6.9	15.5	-2.9	2.4	-2.5	-2.1	-1.2	-3.5	-1.7	-2.2	-3.9	-3.4	-1.5
Blood clot in the leg (DVT)	1.1	1.4	3.6	-1.9	1.1	-1.5	-1.0	-1.7	-1.0	0.6	0.5	-1.1	-1.1	0.4
Medication: Paracetamol	2.5	4.1	13.8	-1.9	3.7	-1.8	-2.0	-0.4	-2.6	-1.3	-1.2	-1.0	-2.6	-1.5
Headache pain in last month	5.1	8.8	18.7	-3.8	3.0	-3.6	-4.3	-3.1	-3.6	0.2	-0.2	-1.6	-3.9	-0.3
Medication for cholesterol, blood pressure or diabetes	2.7	4.5	10.3	-2.0	2.3	-1.9	-1.8	-1.1	-3.2	-1.3	-1.6	-2.1	-3.1	-2.0
Glaucoma (self-reported)	2.4	2.8	7.3	-1.7	2.7	-1.5	-1.2	-1.1	-2.1	-1.5	-1.6	-1.4	-1.9	-0.9
Gout (self-reported)	1.8	2.4	7.3	-1.3	1.9	-2.7	-1.2	-1.8	-2.0	-0.7	-0.2	0.1	-1.9	-1.3
Hypothyroidism/myxoedema (self-reported)	0.7	1.3	3.7	0.5	-1.9	0.2	0.6	0.0	1.6	0.5	0.9	-0.4	1.5	1.9
Medication: Amlodipine	1.6	2.2	6.4	2.5	-0.3	0.9	2.0	1.8	1.4	-1.1	-0.3	1.8	1.6	-1.1
Medication: Ventolin 100micrograms inhaler	0.5	0.7	3.0	-0.3	1.7	0.8	-0.6	0.9	-0.5	-0.6	-0.9	-0.4	-0.5	-0.8
Birth weight	1.4	3.1	8.6	-0.8	-1.7	-2.4	-1.4	-2.2	-0.1	2.2	2.9	1.5	-0.5	1.5
Chronic bronchitis/emphysema (mother)	0.8	0.9	3.5	-1.8	0.3	-1.0	-0.4	-1.9	-0.6	0.5	0.6	-0.6	-0.7	0.5
High blood pressure (siblings)	0.1	0.2	0.5	0.1	-0.1	0.0	0.7	0.1	0.7	0.2	0.6	0.6	0.7	-0.1
Forced vital capacity (FVC), Best measure	0.9	3.4	12.6	-1.7	0.1	-3.5	-2.1	-2.8	-1.3	1.2	1.6	0.9	-1.6	0.7
Body fat percentage	0.1	0.3	1.8	0.3	0.7	1.3	0.1	0.5	0.1	-0.1	-0.4	0.1	0.1	-0.2
Leg fat percentage (right)	1.0	3.7	12.2	2.5	0.5	3.5	2.1	2.8	1.6	-1.3	-1.3	0.4	1.9	-0.4
Arm fat-free mass (right)	2.7	13.7	37.2	1.4	-3.0	0.7	0.8	-1.0	4.0	4.8	5.5	6.1	3.5	4.4
Exposure to tobacco smoke outside home	0.2	0.3	0.9	-0.4	0.6	-0.9	-0.8	-0.7	-0.2	0.4	0.5	-0.1	-0.2	0.7
Comparative body size at age 10	1.8	4.9	15.7	1.6	-1.2	4.0	2.6	2.7	3.0	0.8	0.5	1.2	3.0	0.9
Number of full brothers	1.0	1.3	3.7	1.4	-0.9	1.9	1.1	1.4	1.4	0.2	0.2	0.8	1.4	-0.5
Worry too long after embarrassment	1.8	3.0	6.7	-0.6	2.2	-0.6	-1.3	0.2	-2.6	-1.4	-2.2	-1.1	-2.5	-2.1
Seen a psychiatrist for nerves, anxiety, tension or depression	2.7	3.5	8.0	-1.7	2.8	-2.2	-2.6	-1.5	-2.4	0.2	-0.4	-1.0	-2.6	-0.5
Wheeze or whistling in the chest in last year	1.8	3.2	6.2	-2.0	2.0	-2.2	-2.2	-2.2	-2.2	0.8	0.6	0.1	-2.5	-0.5
Number of children fathered	0.7	0.8	2.7	1.3	0.4	1.6	0.4	1.3	0.8	0.4	-0.0	1.0	0.8	0.4
Reason for reducing amount of alcohol drunk: Health precaution	2.0	2.3	7.8	-2.8	0.1	-1.8	-1.6	-2.3	-1.3	0.5	0.5	-1.5	-1.5	0.4
Age at first live birth	0.4	0.8	3.3	-0.0	-1.8	-0.5	0.1	-0.2	0.7	1.0	0.9	0.4	0.6	1.5
Pulse wave peak to peak time	1.8	2.1	5.7	-2.3	-0.2	-1.7	-1.7	-2.4	-0.6	1.2	1.2	-0.9	-0.8	1.3
Health satisfaction	0.1	0.2	0.5	0.2	0.7	0.5	0.6	0.1	0.2	-0.4	-0.3	0.7	0.2	-0.0
Shortness of breath walking on level ground	0.9	1.1	7.0	0.3	1.2	0.2	0.2	-0.5	0.4	1.2	1.3	2.6	0.2	-0.1
Qualifications: College or University degree	0.9	2.8	7.7	-2.1	0.7	-1.7	-2.2	-1.9	-1.5	0.2	-0.4	-2.8	-1.6	0.9
Eye problems/disorders: None of the above	2.0	2.3	5.0	2.1	-1.3	2.0	1.7	2.2	0.5	-1.5	-1.2	-0.4	0.8	-1.5
Mouth/teeth dental problems: Loose teeth	0.6	0.7	2.7	-1.5	0.3	-1.0	-0.9	-1.6	-0.6	0.3	0.2	-0.5	-0.7	0.2
Emphysema/chronic bronchitis	0.7	0.8	3.2	-0.8	-1.3	-1.8	-0.3	-1.1	-0.8	-0.0	0.3	-0.6	-0.8	-0.6
Medication for pain relief, constipation, heartburn	0.7	1.2	7.2	0.9	-2.7	0.7	1.3	0.7	0.8	-0.5	-0.2	-0.8	0.8	0.1
Neck or shoulder pain in last month	0.9	1.3	2.9	-0.0	1.6	-0.4	0.3	0.2	-1.3	-1.7	-1.7	-0.9	-1.1	-1.3
Medication: Blood pressure	3.0	5.3	11.7	2.0	-3.1	1.5	2.0	0.8	3.4	1.7	2.1	1.9	3.3	2.3
Angina (self-reported)	0.5	0.7	1.6	0.8	-0.8	0.4	0.7	0.6	1.3	0.6	0.8	1.0	1.2	0.3
Migraine (self-reported)	2.6	3.2	7.8	-2.8	0.4	-2.7	-2.3	-2.2	-1.7	0.4	0.3	-1.4	-1.8	1.0
Medication: Ibuprofen	1.4	1.6	4.3	1.2	-0.5	1.4	0.5	0.8	1.8	1.2	1.0	2.1	1.7	0.9
Medication: Allopurinol	1.0	1.3	3.7	-0.9	1.6	-1.9	-0.7	-1.1	-1.4	-0.7	-0.3	0.2	-1.4	-0.8
Medication: Omeprazole	0.4	0.5	2.3	0.6	1.5	0.5	0.8	0.8	-0.2	-0.8	-0.7	-0.1	-0.0	-0.7
Medication: Seretide 50 evohaler	0.2	0.2	0.9	0.7	-0.5	0.3	0.4	0.2	-0.0	-0.2	-0.0	0.9	0.0	-0.9
Mean time to correctly identify matches	0.1	0.3	0.7	0.4	-0.8	-0.2	0.4	-0.3	0.5	0.4	0.8	-0.7	0.5	0.0
Heart disease (mother)	0.4	0.5	1.2	1.1	0.5	0.5	0.4	1.0	0.4	-1.0	-0.7	-0.6	0.5	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.3	3.3	1.6	-0.7	1.8	1.2	1.0	0.7	-0.9	-1.1	0.8	0.8	-1.1
Whole body fat mass	0.4	1.5	4.1	0.6	-0.5	1.1	0.4	-0.0	1.5	1.5	1.6	2.0	1.3	1.5
Leg fat mass (right)	1.0	4.0	7.9	2.3	-0.7	2.8	1.8	1.5	2.6	1.0	1.2	2.6	2.5	1.3
Arm predicted mass (right)	2.7	13.7	34.9	1.4	-3.3	0.6	1.0	-1.0	4.1	4.7	5.4	5.9	3.5	4.4
Pulse rate, automated reading	5.7	18.4	33.9	-2.0	5.8	-0.7	-2.1	0.7	-5.5	-5.0	-5.8	-5.1	-5.0	-4.4
Alcohol intake frequency.	0.7	1.7	4.0	-0.8	1.8	-1.1	-1.0	-0.7	-2.0	-0.8	-0.9	-0.2	-2.0	-1.6
Comparative height size at age 10	3.1	17.3	36.7	-5.7	1.1	-5.8	-5.1	-6.1	-3.8	3.5	3.1	0.6	-4.6	1.4
Number of full sisters	0.4	0.5	1.4	0.4	-0.8	0.7	0.5	0.3	0.4	0.7	0.9	1.2	0.3	-1.0
Suffer from ‘nerves’	4.5	7.1	16.6	-3.2	1.5	-4.1	-3.7	-3.7	-2.7	1.5	1.3	-0.1	-3.1	0.5
Overall health rating	0.6	1.3	4.0	-0.4	2.0	-0.7	-0.3	-0.3	-1.6	-1.2	-1.3	-0.6	-1.5	-1.2
Chest pain or discomfort	2.3	3.3	6.2	-2.4	1.4	-2.5	-2.1	-2.3	-2.2	-0.2	-0.2	-1.4	-2.3	-0.5
Had major operations	0.8	0.9	2.1	0.8	-0.6	0.7	1.5	1.1	0.7	-1.2	-0.6	-1.3	1.0	-0.0
Age at last live birth	0.4	0.6	1.3	-0.7	-1.0	-0.5	0.2	-0.7	0.6	0.9	1.0	0.5	0.5	1.1
Family relationship satisfaction	3.9	4.7	10.1	-3.2	1.4	-2.7	-3.0	-2.1	-3.0	0.2	-0.4	-0.9	-3.1	0.2
Leg pain on walking	0.9	1.1	2.7	1.4	-0.1	0.6	1.5	1.2	0.2	-1.6	-0.9	0.0	0.4	-1.4
Qualifications: NVQ or HND or HNC or equivalent	1.7	2.1	6.4	-0.6	1.3	-0.1	-0.4	0.5	-1.2	-2.1	-2.2	-2.5	-1.0	-1.5
Commuting to job workplace: Car/motor vehicle	0.4	0.4	1.2	-0.1	-0.5	-0.5	-0.4	-0.5	0.5	0.9	1.1	0.6	0.4	0.9
Illness, injury, bereavement, stress in last 2 years	2.4	3.0	12.3	1.3	-3.5	0.2	1.7	0.3	2.1	1.0	1.8	1.8	2.0	0.6
Medication: Aspirin	0.3	0.4	1.1	0.6	0.7	0.5	0.0	0.5	-0.0	-1.0	-1.0	-0.5	0.1	-1.0
Supplements: Vitamin C	0.3	0.3	2.3	1.5	-0.1	-0.1	0.4	0.5	0.2	-0.3	-0.1	0.5	0.3	-0.5
Knee pain experienced in last month	1.4	2.2	4.9	1.4	1.0	1.4	1.3	1.9	-0.3	-2.2	-2.2	-1.0	0.0	-1.8
Hypertension (Self-reported)	1.5	4.2	9.6	2.6	-2.1	2.0	2.8	1.7	2.9	-0.6	0.3	1.2	3.1	0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.5	-0.7	-0.1	0.2	-0.3	-0.4	-0.0	0.7	0.4	0.3	-0.1	0.3
Illnesses of father: Heart disease	1.3	1.7	4.0	2.0	-0.2	1.4	0.8	1.5	0.6	-1.7	-1.9	-1.3	0.9	-1.0
Illnesses of siblings: Diabetes	0.7	0.9	3.5	0.7	-1.9	0.7	1.5	0.7	1.1	0.1	0.5	0.0	1.1	0.1
Smoking status: Previous	1.8	2.7	7.6	1.8	-0.5	2.8	2.0	1.9	2.2	0.3	0.4	1.3	2.2	0.4
Forced expiratory volume in 1-second (FEV1), predicted	3.3	6.9	15.1	-3.9	0.0	-3.5	-3.4	-3.9	-2.0	2.3	1.9	0.5	-2.5	1.4
Whole body fat-free mass	2.9	16.3	41.1	1.0	-3.6	0.2	0.7	-1.6	4.2	5.4	6.2	6.4	3.5	4.9
Leg fat-free mass (right)	2.6	14.1	36.1	0.8	-3.0	0.4	0.5	-1.3	3.9	5.2	5.9	6.0	3.2	4.5
Arm fat percentage (left)	0.4	1.7	5.8	1.3	-0.2	2.4	1.2	1.1	1.7	0.5	0.5	1.5	1.6	0.6
Average weekly red wine intake	0.8	1.2	4.2	-0.2	0.6	1.2	-0.9	0.5	1.1	1.6	0.9	0.8	0.9	2.1
Handedness (chirality/laterality): Left-handed	0.4	0.4	1.3	0.1	-0.2	0.1	-0.3	-1.0	0.5	0.8	0.4	1.0	0.4	1.1
Mood swings	2.7	5.0	12.3	-2.3	0.1	-2.1	-2.3	-3.5	-0.4	3.0	2.6	1.5	-0.9	2.8
Loneliness, isolation	1.7	2.4	7.7	-1.2	-0.3	-1.4	-1.3	-1.9	0.1	2.8	2.2	0.8	-0.3	2.0
Long-standing illness, disability or infirmity	1.4	2.2	4.5	1.4	1.4	2.1	1.6	1.6	-0.2	-1.5	-2.0	0.7	0.1	-2.0
Ever had bowel cancer screening	0.2	0.2	0.6	0.2	-0.7	-0.4	0.2	-0.5	-0.4	-0.7	-0.7	-0.3	-0.3	-0.8
Diabetes diagnosed by doctor	2.6	4.3	10.1	2.7	-0.8	3.2	3.1	2.3	2.1	-1.1	-0.9	1.3	2.4	-0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	1.6	-0.2	0.9	1.0	0.7	0.4	-0.4	-1.0	-1.0	0.7	-0.2	-1.3
Friendships satisfaction	3.4	4.2	10.5	-3.2	-0.1	-2.2	-2.9	-2.9	-1.4	2.0	1.2	-0.0	-1.8	1.8
Qualifications: nursing, teaching	0.5	0.7	2.1	0.9	-0.3	1.4	0.0	1.0	0.7	-0.3	-0.5	-1.4	0.8	0.7
Commuting to job workplace: Walk	2.1	2.3	5.8	0.3	1.6	0.5	0.7	1.5	-1.3	-2.3	-2.1	-0.9	-1.0	-2.4
Eye problems/disorders: Cataract	2.1	2.4	5.6	-2.4	0.8	-1.7	-1.9	-2.0	-0.3	1.8	1.1	-0.8	-0.6	2.0
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	3.4	0.7	-0.3	0.4	0.8	0.3	-0.6	-0.0	0.2	0.4	-0.6	-1.9
Medication for cholesterol	4.3	6.5	13.7	-2.5	-1.8	-2.7	-2.4	-3.5	0.2	3.6	3.7	1.1	-0.4	3.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.7	3.2	7.8	-1.6	0.8	-1.9	-1.7	-2.5	-0.1	2.8	2.6	0.8	-0.5	1.9
Back pain experienced in last month	1.5	2.2	6.9	1.6	-1.6	1.4	2.6	1.3	1.7	-0.2	0.5	1.3	1.9	-0.3
Mineral and other dietary supplements	2.2	3.0	6.0	-2.4	0.4	-2.1	-2.0	-1.8	-2.1	-0.6	-0.9	-2.2	-2.1	-0.5
Breast cancer (self-reported)	0.7	0.8	2.5	0.4	1.0	0.4	-0.1	0.6	-0.8	-1.2	-1.6	-0.7	-0.6	-1.4
Asthma (self-reported)	0.2	0.3	0.9	-1.0	0.9	-0.2	-0.4	-0.5	-0.5	0.5	0.5	-0.1	-0.7	-0.3
Osteoporosis (self-reported)	0.1	0.1	0.4	0.6	0.1	0.3	0.2	0.7	0.1	-0.2	-0.6	-0.1	0.2	-0.3
Osteoarthritis (self-reported)	0.5	0.6	2.5	1.0	1.6	0.7	0.5	0.8	0.1	-1.1	-0.7	-0.4	0.3	-0.1
Medication: Aspirin	0.3	0.4	1.0	0.6	0.7	0.3	-0.1	0.4	-0.1	-0.9	-0.9	-0.6	0.0	-1.0
Medication: Gliclazide	1.2	1.3	3.5	-0.1	0.6	0.7	0.4	0.3	-0.9	-1.8	-1.9	-1.4	-0.7	-1.8
Illnesses of father: None of the above (group 1)	0.7	0.8	2.4	-0.6	1.2	-0.6	-0.7	-0.2	-1.6	-0.4	-0.5	0.4	-1.6	-1.0
Smoking status: Current	1.4	2.3	7.2	1.7	-0.3	2.7	2.0	2.1	1.3	-0.6	-0.7	0.6	1.4	-1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.3	3.4	1.5	-0.9	-0.0	1.2	0.8	0.5	-1.8	-1.5	-1.5	0.8	-0.4
Whole body water mass	3.0	16.9	43.1	1.1	-3.6	0.3	0.8	-1.4	4.4	5.5	6.2	6.6	3.7	4.9
Leg predicted mass (right)	2.6	13.9	36.3	0.8	-3.0	0.5	0.6	-1.3	3.9	5.1	5.8	6.0	3.2	4.3
Arm fat mass (left)	1.1	4.3	10.6	1.8	-1.0	2.4	1.4	0.9	2.8	1.7	2.0	3.2	2.6	1.8
Number of self-reported non-cancer illnesses	0.1	0.1	0.4	0.2	0.3	-0.1	0.1	0.2	0.6	0.0	0.1	0.3	0.6	0.5
Average weekly champagne plus white wine intake	2.9	4.0	9.7	2.7	-3.1	1.6	2.2	1.9	2.6	0.1	0.7	1.0	2.7	0.5
Miserableness	1.5	2.6	6.7	1.1	-0.6	-0.2	-0.0	-0.0	1.7	2.3	2.6	2.6	1.4	1.8
Guilty feelings	3.1	4.7	11.2	-2.6	2.1	-3.3	-2.9	-2.5	-2.5	1.0	0.5	-0.4	-2.7	0.4
Wears glasses or contact lenses	5.6	6.5	14.5	2.6	-3.8	1.7	2.0	0.9	3.7	1.8	2.0	1.6	3.7	2.3
Ever taken oral contraceptive pill	0.4	0.4	1.7	0.6	0.4	1.3	0.8	0.4	0.5	-0.1	-0.2	0.8	0.6	-0.4
Hearing aid user	2.4	2.8	5.3	2.1	-0.6	2.2	2.3	2.0	1.8	-0.2	-0.1	2.1	1.9	-0.3
Mother’s age at death	1.2	1.5	5.3	-1.3	-1.6	-2.3	-0.8	-1.5	-0.4	0.7	1.3	-0.7	-0.6	1.2
Financial situation satisfaction	0.2	0.3	1.4	-0.9	0.1	0.3	0.5	-0.7	-0.1	0.1	0.1	1.2	-0.1	0.1
Tinnitus: Yes, now most or all of the time	2.6	3.1	5.7	-1.9	1.5	-2.4	-1.8	-1.6	-2.4	-0.8	-0.8	-1.7	-2.4	-1.1
Commuting to job workplace: Public transport	0.2	0.3	1.0	-0.7	1.0	0.1	-0.6	0.1	-0.5	0.0	-0.2	-0.5	-0.5	0.3
Eye problems/disorders: Glaucoma	1.2	1.4	2.8	-1.4	1.4	-1.7	-0.7	-1.2	-1.4	-1.0	-0.8	-0.5	-1.3	-0.7
Medication: Blood pressure	1.5	2.8	5.7	2.2	-0.3	2.1	2.3	2.4	1.3	-1.8	-1.4	0.3	1.7	-1.2
Pain type(s) experienced in last month: Hip pain	2.4	3.0	7.4	1.2	2.4	1.4	0.5	1.8	-1.2	-2.5	-2.7	-0.9	-0.8	-2.1
Supplements: Fish oil (including cod liver oil)	2.5	3.3	6.6	2.0	-1.0	1.7	2.0	0.9	2.5	1.1	1.4	2.6	2.4	1.1
High cholesterol (Self-reported)	1.1	1.9	4.0	1.5	-1.1	1.2	2.0	0.7	1.9	-0.1	0.5	1.9	2.0	0.2
Medication: Bendroflumethiazide	2.1	3.2	7.3	2.7	-1.3	2.2	2.4	1.7	1.8	-0.9	-0.5	1.9	2.0	-0.8
Medication: Paracetamol	0.7	1.1	4.2	-0.8	2.1	-1.3	-1.0	-0.3	-1.2	-0.5	-0.0	0.3	-1.2	-0.9
Medication: Lisinopril	0.9	1.1	3.2	0.9	0.4	1.8	1.1	1.5	0.9	-0.9	-1.0	0.3	1.1	-1.0
Medication: Atorvastatin	1.3	1.6	3.5	0.9	-1.0	0.6	1.9	1.3	0.9	-1.8	-1.3	-1.5	1.3	-0.5
Illnesses of father: High blood pressure	1.4	1.7	3.6	0.7	-1.9	-0.8	1.0	-0.3	1.8	0.8	1.6	0.9	1.8	1.6
Alcohol drinker status: Never	0.5	0.5	2.0	-0.9	1.4	-1.0	-1.0	-0.5	-0.6	0.1	-0.1	-0.3	-0.6	0.1
Ever smoked	4.3	7.6	14.8	3.3	-2.3	3.5	3.4	3.2	3.7	0.3	0.8	1.9	3.8	1.0
Basal metabolic rate	2.5	13.8	36.2	1.0	-3.1	0.4	0.7	-1.3	3.9	4.9	5.7	6.0	3.3	4.5
Leg fat percentage (left)	0.9	3.4	11.3	2.4	0.5	3.4	2.1	2.7	1.5	-1.2	-1.1	0.7	1.8	-0.3
Arm fat-free mass (left)	2.7	13.6	36.5	1.4	-2.9	0.6	0.9	-0.9	4.1	4.7	5.4	6.0	3.5	4.6
Number of operations (self-reported)	0.4	0.6	2.1	-0.0	1.0	0.5	-0.1	0.7	-0.5	-0.9	-0.9	-1.4	-0.4	-0.9
Average weekly beer plus cider intake	0.5	0.7	1.5	-0.6	-1.1	-1.0	-0.3	-0.9	-0.9	-0.6	-0.2	-1.2	-0.9	-0.6
Irritability	1.8	3.1	6.8	0.9	-1.0	1.3	0.0	0.0	2.3	2.6	2.3	1.9	1.9	2.3
Risk taking	0.8	1.2	4.3	-0.6	2.1	-0.7	-0.7	-0.1	-1.3	-1.2	-1.1	-0.8	-1.2	-0.7
Ever had prostate specific antigen (PSA) test	0.9	1.1	2.5	0.3	-1.3	-0.4	-0.4	-0.7	1.2	1.4	1.5	0.4	1.0	1.6
Fractured/broken bones in last 5 years	0.7	0.9	1.6	1.1	-1.0	1.1	1.3	0.8	0.5	-0.2	-0.2	1.2	0.6	-1.2
Age started oral contraceptive pill	1.6	2.0	6.8	-0.1	-1.4	-1.0	-0.0	-1.1	1.5	1.9	2.1	-0.0	1.3	2.6
Diastolic blood pressure, automated reading	0.8	2.5	6.9	-0.4	2.6	-0.9	-0.8	0.2	-2.2	-1.7	-1.7	-0.2	-2.1	-1.8
Ever depressed for a whole week	0.6	0.8	2.2	0.5	1.0	1.0	-0.2	0.7	-0.7	-0.8	-1.5	-1.2	-0.6	-0.7
Unable to work because of sickness or disability	1.1	1.4	5.2	0.4	0.4	-0.3	0.5	0.6	-1.3	-1.8	-1.5	-0.8	-1.0	-2.3
Commuting to job workplace: Cycle	1.3	1.5	6.0	1.3	-2.4	0.2	1.7	0.4	1.5	-0.2	0.3	0.8	1.6	0.8
Myopia	2.2	3.2	8.8	2.3	-1.5	3.0	2.2	2.5	1.9	-0.1	-0.5	0.5	2.0	-0.4
Vascular/heart problems diagnosed by doctor	1.1	3.1	7.7	-1.9	1.6	-1.8	-2.2	-1.6	-2.6	0.2	-0.4	-1.1	-2.8	-0.9
Cholesterol lowering medication	0.3	0.5	1.2	0.6	0.4	0.5	0.9	0.7	0.0	-1.1	-1.0	-0.3	0.2	-0.8
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	2.0	0.4	1.4	0.2	0.6	0.7	-0.2	-0.9	-0.7	-0.5	-0.1	-0.6
Pain experienced in last month	0.1	0.2	0.6	-0.3	-0.5	-0.1	-0.7	-0.2	0.2	0.4	-0.1	-0.6	0.2	0.5
Supplements: Calcium	0.2	0.2	0.5	0.0	-0.1	-0.1	0.2	-0.5	0.5	0.5	0.7	0.6	0.5	0.3
Basal cell carcinoma (self-reported)	3.9	4.6	7.7	-2.2	2.7	-2.4	-2.4	-1.2	-2.8	-1.1	-1.4	-2.7	-2.7	-0.7
Heart attack/myocardial infarction (self-reported)	0.9	1.2	3.3	1.0	-0.6	1.8	1.3	1.3	0.8	-0.9	-1.5	-0.7	1.0	-0.5
Deep venous thrombosis (DVT) (self-reported)	1.3	1.7	4.5	-2.1	1.3	-1.6	-1.1	-1.9	-1.3	0.6	0.6	-0.9	-1.4	0.3
Heart disease (siblings)	0.1	0.1	0.2	-0.0	0.3	-0.4	-0.3	-0.4	0.0	0.3	0.2	0.4	-0.0	-0.1
Alcohol drinker status: Previous	1.1	1.3	3.5	0.8	1.0	0.9	0.5	0.4	-0.7	-1.7	-1.9	-0.9	-0.5	-1.8
Pack years of smoking	1.5	2.2	4.8	-0.7	2.0	-1.0	-0.5	-0.9	-2.0	-1.5	-1.4	-0.9	-1.9	-2.2
Impedance of whole body	9.3	47.4	90.8	-8.0	5.6	-7.0	-7.1	-5.1	-9.5	-3.1	-4.7	-8.6	-9.5	-3.9
Leg fat mass (left)	1.0	3.9	8.0	2.2	-0.6	2.7	1.7	1.5	2.5	1.1	1.3	2.8	2.4	1.3
Arm predicted mass (left)	2.5	12.9	37.0	1.6	-3.0	0.9	1.2	-0.8	4.0	4.3	5.1	6.1	3.5	4.2