[Hub]/) : Traits : Leg fat percentage (left) : ← →

chr4:2,152,449-3,943,984

Best TWAS P=2.29e-09 · Best GWAS P=1.5e-08 conditioned to 0.855

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
5	GTEx	Cells Transformed fibroblasts	NOP14	0.12	0.06	enet	11	0.09	2.9e-07	-4.3	6.0	2.3e-09	-0.77	0.10	0.88	TRUE
11	GTEx	Muscle Skeletal	HTT	0.22	0.02	lasso	9	0.06	1.3e-06	-4.9	-5.3	8.7e-08	0.17	0.14	0.82	TRUE
23	The Cancer Genome Atlas	Lung Adenocarcinoma	C4orf44	0.03	0.04	lasso	4	0.05	2.9e-06	-5.4	5.9	3.5e-09	-0.36	0.01	0.99	FALSE
7	GTEx	Colon Transverse	GRK4	0.27	0.25	enet	18	0.25	2.4e-12	-5.1	5.8	4.8e-09	-0.95	0.03	0.97	FALSE
21	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C4orf44	0.03	0.02	blup	42	0.02	8.0e-04	-5.3	5.8	5.9e-09	-0.32	0.01	0.98	FALSE
2	GTEx	Adrenal Gland	GRK4	0.38	0.25	lasso	5	0.29	5.1e-11	-4.9	5.8	6.5e-09	-0.88	0.17	0.83	FALSE
16	GTEx	Whole Blood	HTT	0.10	0.00	enet	15	0.03	1.4e-03	5.0	5.8	7.3e-09	-0.40	0.10	0.45	FALSE
26	The Cancer Genome Atlas	Soft Tissue Sarcoma	GRK4	0.08	0.07	blup	77	0.09	4.4e-06	-4.7	5.7	1.5e-08	-0.90	0.06	0.93	FALSE
22	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	GRK4	0.09	0.18	lasso	5	0.20	1.5e-22	-5.7	5.6	1.8e-08	-0.95	0.01	0.99	FALSE
9	GTEx	Lung	ADD1	0.09	0.02	enet	6	0.01	3.5e-02	4.1	5.5	3.1e-08	-0.71	0.29	0.47	FALSE
12	GTEx	Pituitary	GRK4	0.17	0.00	enet	6	-0.01	5.6e-01	-5.7	5.5	3.5e-08	-0.99	0.04	0.62	FALSE
29	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	GRK4	0.11	0.12	lasso	1	0.10	8.4e-04	-5.5	5.5	4.5e-08	-0.98	0.02	0.90	FALSE
25	The Cancer Genome Atlas	Rectum Adenocarcinoma	GRK4	0.27	0.10	blup	76	0.13	7.3e-04	-4.9	5.4	5.4e-08	-0.87	0.04	0.75	FALSE
13	GTEx	Stomach	GRK4	0.22	0.19	lasso	7	0.19	2.6e-09	-5.3	5.4	7.7e-08	-0.96	0.06	0.94	FALSE
14	GTEx	Thyroid	NOP14-AS1	0.18	0.09	lasso	8	0.11	1.3e-08	-5.1	5.3	9.7e-08	-0.94	0.11	0.88	FALSE
8	GTEx	Esophagus Gastroesophageal Junction	GRK4	0.37	0.23	lasso	9	0.22	2.2e-08	-5.3	5.3	1.0e-07	-0.96	0.04	0.96	FALSE
15	GTEx	Uterus	GRK4	0.31	0.24	enet	29	0.32	2.5e-07	-5.3	5.3	1.1e-07	-0.88	0.04	0.90	FALSE
19	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	GRK4	0.09	0.12	blup	76	0.12	1.7e-06	-4.8	5.3	1.1e-07	-0.93	0.04	0.95	FALSE
27	The Cancer Genome Atlas	Soft Tissue Sarcoma	SH3BP2	0.08	0.03	blup	53	0.02	2.8e-02	5.0	5.3	1.3e-07	-0.39	0.00	0.50	FALSE
28	The Cancer Genome Atlas	Stomach Adenocarcinoma	GRK4	0.17	0.24	lasso	6	0.24	1.2e-17	-4.9	5.3	1.3e-07	-0.96	0.06	0.94	FALSE
1	GTEx	Adipose Subcutaneous	GRK4	0.30	0.39	lasso	6	0.41	1.2e-35	-4.9	5.3	1.4e-07	-0.97	0.07	0.93	FALSE
3	GTEx	Artery Aorta	GRK4	0.29	0.38	enet	11	0.40	1.3e-23	-4.9	5.2	1.7e-07	-0.96	0.09	0.91	FALSE
10	GTEx	Lung	HTT	0.06	0.00	lasso	4	0.00	5.8e-01	-4.6	5.2	1.7e-07	-0.81	0.10	0.37	FALSE
18	The Cancer Genome Atlas	Breast Invasive Carcinoma	GRK4	0.11	0.17	lasso	7	0.18	6.7e-36	-4.9	5.2	2.2e-07	-0.97	0.06	0.94	FALSE
20	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	RNF4	0.14	0.02	blup	47	0.07	3.1e-04	4.3	5.2	2.4e-07	-0.22	0.00	0.12	FALSE
6	GTEx	Cells Transformed fibroblasts	GRK4	0.32	0.35	lasso	7	0.37	3.1e-29	-5.1	5.2	2.5e-07	-0.97	0.05	0.95	FALSE
24	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	GRK4	0.10	0.14	enet	16	0.14	4.6e-15	-4.9	5.2	2.5e-07	-0.93	0.08	0.92	FALSE
17	ROSMAP	Brain Pre-frontal Cortex	GRK4	0.12	0.14	lasso	4	0.14	1.8e-17	-4.9	5.1	2.8e-07	-0.95	0.04	0.95	FALSE
4	GTEx	Breast Mammary Tissue (Female)	GRK4	0.23	0.24	lasso	3	0.24	1.1e-07	-5.1	5.1	3.0e-07	-0.97	0.07	0.93	FALSE