[Hub]/) : Traits : Leg fat percentage (left) :

chr6:25,035,920-26,689,223

Best TWAS P=3.62e-17 · Best GWAS P=7.38e-19 conditioned to 7.65e-09

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Subcutaneous U91328.19 0.40 0.46 lasso 8 0.46 4.2e-41 -6.6 6.5 9.9e-11 -0.33 1.00 0.00 FALSE
2 GTEx Adipose Visceral Omentum U91328.19 0.21 0.25 lasso 8 0.27 3.7e-14 -6.6 6.9 6.5e-12 -0.36 1.00 0.00 FALSE
3 GTEx Adrenal Gland U91328.19 0.28 0.12 lasso 10 0.14 1.3e-05 -5.7 7.4 1.2e-13 -0.43 0.94 0.00 FALSE
4 GTEx Artery Aorta U91328.19 0.32 0.24 lasso 7 0.25 8.3e-14 -6.9 7.2 6.3e-13 -0.39 1.00 0.00 FALSE
5 GTEx Artery Coronary U91328.19 0.32 0.16 enet 44 0.23 3.7e-08 -6.6 5.2 2.3e-07 -0.12 0.79 0.01 FALSE
6 GTEx Artery Tibial U91328.19 0.26 0.32 lasso 5 0.31 1.6e-24 -6.6 6.7 1.6e-11 -0.35 1.00 0.00 FALSE
7 GTEx Brain Caudate basal ganglia U91328.19 0.23 0.16 lasso 10 0.16 3.1e-05 -5.7 6.4 1.8e-10 -0.34 0.64 0.14 FALSE
8 GTEx Brain Cerebellar Hemisphere U91328.19 0.47 0.33 enet 44 0.26 2.8e-07 -5.6 6.6 4.4e-11 -0.25 0.98 0.00 FALSE
9 GTEx Brain Cerebellum U91328.19 0.13 0.15 lasso 2 0.09 1.1e-03 -5.5 5.4 6.5e-08 -0.26 0.35 0.04 FALSE
10 GTEx Brain Cortex U91328.19 0.36 0.14 lasso 10 0.15 7.1e-05 -6.7 7.0 2.7e-12 -0.32 0.64 0.04 FALSE
11 GTEx Brain Frontal Cortex BA9 U91328.19 0.17 0.16 lasso 4 0.18 1.8e-05 -6.7 6.8 1.2e-11 -0.32 0.44 0.07 FALSE
12 GTEx Breast Mammary Tissue U91328.19 0.38 0.39 lasso 5 0.38 2.2e-20 -6.6 6.7 2.5e-11 -0.34 1.00 0.00 FALSE
13 GTEx Breast Mammary Tissue (Male) U91328.19 0.35 0.15 enet 25 0.15 2.9e-04 -6.6 5.4 7.2e-08 -0.27 0.38 0.04 FALSE
14 GTEx Breast Mammary Tissue (Female) U91328.19 0.39 0.27 lasso 6 0.23 1.4e-07 -6.6 6.8 1.1e-11 -0.33 0.95 0.00 FALSE
15 GTEx Cells Transformed fibroblasts U91328.19 0.58 0.62 lasso 8 0.60 6.2e-56 -6.6 6.4 1.3e-10 -0.33 1.00 0.00 FALSE
16 GTEx Esophagus Gastroesophageal Junction U91328.19 0.28 0.07 lasso 7 0.21 4.3e-08 -6.7 5.7 1.1e-08 -0.35 0.71 0.02 FALSE
17 GTEx Esophagus Mucosa U91328.19 0.45 0.42 lasso 7 0.44 6.3e-32 -6.6 7.0 2.6e-12 -0.37 1.00 0.00 FALSE
18 GTEx Esophagus Muscularis TRIM38 0.06 0.04 lasso 4 0.02 1.7e-02 -6.9 5.6 1.7e-08 -0.35 0.50 0.09 FALSE
19 GTEx Esophagus Muscularis U91328.19 0.36 0.30 lasso 10 0.30 1.7e-18 -6.9 6.7 1.9e-11 -0.39 1.00 0.00 FALSE
20 GTEx Heart Atrial Appendage U91328.19 0.25 0.17 enet 6 0.13 2.0e-06 -6.6 6.9 6.9e-12 -0.35 0.99 0.00 FALSE
21 GTEx Heart Left Ventricle U91328.19 0.20 0.18 lasso 5 0.15 2.4e-08 -6.6 6.5 7.1e-11 -0.31 0.99 0.00 FALSE
22 GTEx Liver U91328.19 0.16 0.14 lasso 2 0.05 1.9e-02 -5.2 5.2 2.1e-07 -0.21 0.28 0.09 FALSE
23 GTEx Lung U91328.19 0.20 0.22 enet 15 0.24 2.9e-18 -7.1 7.2 4.8e-13 -0.37 1.00 0.00 FALSE
24 GTEx Muscle Skeletal U91328.19 0.28 0.26 enet 15 0.32 1.3e-31 -6.6 6.4 2.0e-10 -0.34 1.00 0.00 FALSE
25 GTEx Nerve Tibial U91328.19 0.46 0.38 lasso 10 0.36 1.4e-26 -6.6 6.6 3.2e-11 -0.34 1.00 0.00 FALSE
26 GTEx Ovary U91328.19 0.37 0.17 enet 18 0.34 4.7e-09 -6.7 8.4 3.6e-17 -0.40 0.74 0.04 TRUE
27 GTEx Prostate U91328.19 0.30 0.39 lasso 2 0.37 3.0e-10 -6.6 6.6 5.0e-11 -0.33 0.95 0.02 FALSE
28 GTEx Skin Not Sun Exposed Suprapubic U91328.19 0.39 0.37 lasso 11 0.34 2.4e-19 -6.6 6.9 6.4e-12 -0.36 1.00 0.00 FALSE
29 GTEx Skin Sun Exposed Lower leg U91328.19 0.29 0.34 lasso 6 0.34 5.6e-29 -6.6 6.7 2.1e-11 -0.33 1.00 0.00 FALSE
30 GTEx Stomach U91328.19 0.17 0.05 lasso 5 0.05 1.7e-03 -6.6 5.7 1.4e-08 -0.30 0.57 0.04 FALSE
31 GTEx Thyroid U91328.19 0.21 0.17 lasso 5 0.17 6.4e-13 -6.6 6.1 1.0e-09 -0.32 1.00 0.00 FALSE
32 GTEx Uterus U91328.19 0.38 0.05 enet 21 0.04 6.2e-02 -7.1 7.9 2.9e-15 -0.37 0.13 0.34 FALSE
33 GTEx Vagina U91328.19 0.45 0.27 lasso 4 0.26 9.4e-07 -6.6 6.4 2.0e-10 -0.32 0.64 0.02 FALSE
34 METSIM Adipose U91328.19 0.19 0.24 lasso 23 0.25 1.7e-36 -6.6 6.9 3.9e-12 -0.34 1.00 0.00 FALSE
35 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma LRRC16A 0.07 0.04 blup 288 0.03 2.8e-04 -4.9 -6.1 8.7e-10 0.04 0.02 0.96 TRUE