TWAS hub - LRRC16A

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0870	0.0320	1.3e-03	0.015	0.029	0.032	0.026	0.034	4.9e-03	1.4e-04	8.6e-05	3.7e-04	5.0e-05
2	GTEx	Cells EBV-transformed lymphocytes	0.5080	0.0970	5.8e-05	0.188	NA	0.136	NA	0.175	9.4e-07	NA	3.6e-05	NA	2.3e-06
3	GTEx	Cells Transformed fibroblasts	0.1880	0.0500	1.6e-05	0.013	NA	0.099	NA	0.080	3.6e-02	NA	7.8e-08	NA	1.3e-06
4	GTEx	Heart Left Ventricle	0.2084	0.0614	1.6e-04	0.068	NA	0.100	NA	0.107	1.7e-04	NA	5.3e-06	NA	2.7e-06
5	GTEx	Lung	0.2054	0.0583	9.7e-05	0.149	NA	0.138	NA	0.139	1.7e-11	NA	1.1e-10	NA	8.3e-11
6	GTEx	Whole Blood	0.1370	0.0440	1.6e-03	0.069	NA	0.089	NA	0.093	6.4e-07	NA	1.5e-08	NA	6.8e-09
7	METSIM	Adipose	0.1470	0.0326	4.1e-10	0.066	0.070	0.066	0.075	0.080	3.4e-10	1.2e-10	3.6e-10	2.2e-11	5.5e-12
8	NTR	Blood	0.0755	0.0181	1.4e-08	0.048	0.034	0.056	0.047	0.056	3.8e-15	2.6e-11	1.5e-17	5.8e-15	1.3e-17
9	YFS	Blood	0.2650	0.0359	0.0e+00	0.170	0.147	0.183	0.186	0.187	4.4e-53	1.4e-45	1.3e-57	1.9e-58	9.5e-59
10	TCGA	Bladder Urothelial Carcinoma	0.1390	0.0460	4.5e-05	0.016	0.070	0.074	NA	0.044	1.6e-02	1.6e-06	7.9e-07	NA	1.2e-04
11	TCGA	Kidney Renal Clear Cell Carcinoma	0.0694	0.0286	1.7e-03	0.038	0.029	0.010	NA	0.026	3.5e-05	2.8e-04	2.1e-02	NA	5.5e-04
12	TCGA	Kidney Renal Papillary Cell Carcinoma	0.1920	0.0770	4.6e-03	-0.004	0.010	-0.004	NA	-0.002	6.3e-01	8.7e-02	6.1e-01	NA	4.5e-01
13	TCGA	Lung Adenocarcinoma	0.0737	0.0271	3.4e-04	0.043	0.031	0.037	NA	0.035	8.6e-06	1.5e-04	3.7e-05	NA	5.7e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	2	3	4	5	6	7	8	9	10	11	12	13
Seen a psychiatrist for nerves, anxiety, tension or depression	5.1	6.6	14.7	0.7	0.6	0.2	2.3	2.4	3.0	3.2	3.8	0.4	3.8	3.7	3.4
Reason for reducing amount of alcohol drunk: Health precaution	4.0	4.7	17.1	-1.5	3.1	0.8	2.3	-1.0	0.5	-0.5	0.2	1.5	4.1	3.5	3.1
Mouth/teeth dental problems: Dentures	3.6	6.1	20.3	3.4	-2.2	0.5	-3.2	1.3	-0.5	0.5	-0.4	0.3	-4.5	-3.9	-3.7
Ever had prostate specific antigen (PSA) test	3.5	4.0	16.1	-0.5	0.8	-0.1	2.4	-0.1	1.8	0.6	1.3	1.3	4.0	3.5	3.2
Pulse rate, automated reading	3.0	9.7	23.9	1.1	3.4	4.5	3.5	1.8	2.2	1.3	2.2	4.2	4.9	2.0	4.5
Mouth/teeth dental problems: Mouth ulcers	2.7	4.3	13.6	-1.4	2.1	-2.2	1.7	0.7	3.7	1.8	2.4	1.5	2.3	3.1	1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	2.6	4.0	11.3	-0.0	1.5	-1.6	0.7	1.1	3.4	2.4	2.9	0.6	2.6	2.8	2.1
Average weekly fortified wine intake	2.5	2.9	8.6	-1.5	1.4	2.9	1.2	-1.8	-1.5	-2.2	-1.9	2.4	0.9	-0.2	1.6
Nervous feelings	2.5	4.6	18.0	-0.5	-0.2	-0.1	2.9	0.0	1.5	1.3	1.8	0.6	4.2	3.8	3.4
Peak expiratory flow (PEF)	2.5	5.9	20.1	-2.5	1.7	-0.0	3.6	-1.3	1.2	-0.2	0.5	1.2	4.5	3.3	4.3
Risk taking	2.5	3.7	9.6	0.5	3.1	1.1	0.4	1.7	2.5	1.8	2.2	1.1	2.9	2.7	1.7
Father’s age at death	2.4	3.2	12.6	0.8	-0.8	-1.4	1.4	0.7	1.9	1.1	1.5	0.2	3.6	2.1	3.4
Pulse rate	2.4	4.0	10.9	0.7	2.4	2.1	2.2	1.1	2.0	1.1	1.9	1.3	3.2	1.9	3.3
Bilateral oophorectomy (both ovaries removed)	2.3	2.7	4.7	-1.8	1.6	1.0	2.1	-1.7	-1.8	-2.2	-2.1	1.2	1.6	1.4	1.5
Age at first live birth	2.3	4.2	11.5	1.3	0.2	-1.4	3.0	1.4	1.5	1.8	2.4	-0.1	3.0	2.8	3.4
Leg fat percentage (left)	2.3	8.3	37.6	2.4	-1.1	1.0	-2.9	2.4	-0.6	1.1	0.0	-1.0	-6.1	-4.6	-5.0
Schizophrenia (2018)	2.2	4.6	12.0	-3.2	1.9	-0.7	3.1	-1.2	0.1	-0.9	-0.3	-0.5	3.4	3.5	3.1
Diastolic blood pressure, automated reading	2.2	6.7	15.1	-3.6	3.1	2.6	2.9	-1.9	-1.0	-2.2	-1.6	3.9	3.9	1.7	2.2
Pain all over the body in last month	2.1	2.3	6.5	-2.6	-0.0	-1.0	1.1	-2.4	-0.9	-1.7	-1.4	-1.0	2.3	1.7	0.6
Leg fat percentage (right)	2.1	7.4	32.0	2.4	-1.4	0.5	-2.7	2.3	-0.5	1.1	0.0	-0.9	-5.7	-4.5	-4.7
Comparative body size at age 10	2.1	5.7	17.4	1.0	-3.8	-0.1	-3.1	-0.1	-1.7	-0.7	-1.3	-2.6	-4.2	-3.6	-2.8
Leg fat mass (right)	2.1	8.0	31.8	3.2	-1.8	0.1	-2.7	2.8	-0.9	1.0	-0.2	-0.9	-5.6	-4.2	-4.8
Supplements: Fish oil (including cod liver oil)	2.1	2.7	12.6	-1.0	0.5	-0.6	1.8	-0.4	1.6	0.9	1.4	-0.0	3.6	2.9	1.9
Basal cell carcinoma (self-reported)	2.1	2.5	7.0	1.7	1.4	-1.0	0.9	2.4	2.2	2.5	2.6	-0.7	-0.3	1.0	-0.0
Leg fat mass (left)	2.1	8.3	34.2	3.2	-1.5	0.5	-2.6	2.9	-0.9	1.1	-0.2	-1.0	-5.8	-4.2	-4.9
Worry (Nagel 2018)	2.0	4.2	20.0	-1.0	0.6	0.7	2.8	-0.9	1.3	0.5	0.9	0.9	4.5	3.2	3.2
Happiness	2.0	2.4	9.4	-1.1	0.5	-0.5	0.6	-0.6	2.1	0.8	1.2	1.0	2.7	2.2	3.1
Length of working week for main job	2.0	2.2	6.7	0.1	-0.7	1.4	-0.7	-1.1	-2.6	-1.9	-2.4	0.5	-1.7	-1.6	-1.8
Gout (self-reported)	2.0	2.8	11.4	1.7	0.1	3.4	-0.7	-0.1	-1.9	-1.0	-1.5	2.9	-1.5	-1.9	-0.1
Heart disease (mother)	2.0	2.5	6.8	-0.4	1.6	1.5	2.6	-0.4	-2.2	-1.4	-1.1	-0.7	2.2	1.9	1.9
Bipolar Disorder or Schizophrenia	1.9	4.7	12.9	-3.5	2.4	-0.3	2.9	-1.3	0.4	-0.9	-0.2	0.5	3.1	3.6	3.0
Body mass index (BMI)	1.9	8.2	36.6	3.1	-1.7	0.6	-3.0	2.9	-0.7	1.3	0.2	-1.3	-6.0	-3.9	-4.6
Headache pain in last month	1.9	3.2	9.2	-3.0	2.7	0.4	1.3	-1.6	0.8	-0.6	-0.3	2.0	3.0	2.3	1.2
Body fat percentage	1.9	7.4	29.8	3.0	-0.6	1.4	-2.4	3.3	-0.4	1.5	0.6	-0.3	-5.5	-4.0	-4.4
Financial situation satisfaction	1.9	2.3	7.8	-2.8	0.4	0.1	0.7	-2.0	0.6	-1.5	-0.9	2.6	1.8	1.9	1.0
Trunk fat percentage	1.8	7.1	27.5	3.1	-0.2	1.6	-2.3	3.5	-0.4	1.5	0.6	-0.0	-5.2	-3.6	-4.4
Stomach or abdominal pain in last month	1.8	2.2	8.6	-1.0	2.8	-0.3	1.2	0.1	1.5	0.5	0.7	0.6	2.9	2.2	1.1
Hearing difficulty/problems with background noise	1.8	2.8	9.1	-2.5	2.1	3.0	0.7	-2.4	-0.9	-1.5	-1.2	1.8	1.5	0.4	0.8
Forced expiratory volume in 1-second (FEV1)	1.8	6.0	29.6	-2.7	2.8	1.0	2.7	-0.9	0.2	-0.4	0.1	0.6	5.4	3.1	3.7
Medication: Lansoprazole	1.8	2.1	13.3	-0.9	0.2	-0.3	-2.6	-0.2	1.3	0.3	-0.0	-0.2	-1.8	-0.8	-3.6
Arm fat mass (right)	1.8	7.3	26.7	3.4	-1.2	0.4	-2.7	3.4	-0.7	1.4	0.2	-1.0	-5.2	-3.6	-4.5
Eye problems/disorders: None of the above	1.8	2.1	11.0	1.3	0.3	-0.4	-0.1	1.8	3.3	2.1	2.1	1.4	0.6	0.4	0.3
Whole body fat mass	1.8	7.4	28.0	3.4	-1.0	0.9	-2.4	3.4	-0.8	1.3	0.2	-0.8	-5.3	-3.7	-4.6
Suffer from ‘nerves’	1.8	2.8	16.3	-0.4	0.9	1.0	1.7	-0.2	-0.1	0.3	0.5	1.5	4.0	2.4	2.7
Family relationship satisfaction	1.8	2.2	8.1	-1.6	-0.2	-1.5	-0.3	-0.8	2.9	0.7	1.2	0.6	2.2	2.0	1.9
Arm fat mass (left)	1.8	7.3	26.9	3.3	-1.0	0.5	-2.6	3.5	-0.4	1.5	0.4	-1.0	-5.2	-3.5	-4.6
Medication: Blood pressure	1.8	3.3	10.0	-0.3	3.1	2.1	1.6	-1.2	-3.2	-2.1	-2.2	2.4	0.1	0.4	0.5
Trunk fat mass	1.7	7.1	26.4	3.3	-0.8	1.0	-2.3	3.5	-0.7	1.4	0.2	-0.4	-5.1	-3.6	-4.6
Hip circumference	1.7	7.3	25.2	3.9	-1.7	-0.4	-2.5	3.8	0.3	2.3	1.3	-1.2	-5.0	-2.6	-3.8
Arm fat percentage (left)	1.7	6.6	26.1	2.9	-0.6	1.4	-2.3	3.2	-0.6	1.3	0.4	-0.6	-5.1	-3.7	-4.1
Fractured/broken bones in last 5 years	1.7	2.1	8.5	-0.1	-1.9	0.7	-2.9	0.2	-0.4	-0.2	-0.7	-0.3	-0.8	-2.4	-2.8
Depression (Nagel 2018)	1.6	2.4	8.4	-2.4	1.9	0.9	1.0	-0.7	1.7	0.3	0.7	1.8	2.9	2.0	1.1
Ever had hysterectomy (womb removed)	1.6	1.8	4.2	-2.0	1.9	1.3	1.2	-1.7	-0.4	-1.7	-1.7	1.5	1.0	0.4	0.4
High blood pressure	1.6	4.6	13.3	-1.2	2.4	3.3	0.6	-2.0	-3.6	-3.0	-3.1	2.3	0.2	-0.2	0.3
Arm fat percentage (right)	1.6	6.3	22.8	3.1	-0.7	1.1	-2.4	3.2	-0.5	1.5	0.6	-0.8	-4.8	-3.6	-3.9
Time employed in main current job	1.6	1.9	6.5	2.5	-1.8	-0.6	0.0	2.2	1.1	2.1	1.6	-0.7	-0.5	0.4	-0.7
Forced expiratory volume in 1-second (FEV1), Best measure	1.6	5.2	22.1	-2.8	2.5	0.7	2.5	-1.2	0.7	-0.3	0.2	1.4	4.7	3.6	2.7
Emphysema/chronic bronchitis	1.6	1.8	7.0	-0.3	-1.2	-0.2	-0.7	-1.0	-2.6	-1.6	-2.5	-0.5	-0.6	-1.5	-1.4
Illnesses of father: High blood pressure	1.6	1.9	5.7	2.1	0.6	0.0	2.2	0.9	0.8	0.9	1.1	0.3	2.2	1.4	2.4
Ever depressed for a whole week	1.6	2.0	4.6	-2.1	0.8	-0.2	1.6	-1.2	0.4	-0.3	0.3	1.9	2.1	2.0	2.0
Supplements: Zinc	1.5	1.7	7.0	0.4	-1.0	0.7	1.1	-0.2	0.7	0.4	0.8	0.9	2.5	1.8	2.6
Medication: Ibuprofen (e.g. Nurofen)	1.5	1.9	7.8	-0.8	1.2	0.3	1.8	-0.2	1.6	0.7	0.8	2.2	2.8	1.2	1.1
Prospective memory result	1.5	1.8	5.7	-2.4	2.0	-0.2	1.6	-0.9	1.2	-0.5	-0.1	2.1	1.4	1.2	-1.0
Exposure to tobacco smoke at home	1.5	1.7	6.7	1.2	-0.1	-0.0	0.4	2.6	1.8	2.2	2.2	-0.6	-0.4	0.5	0.1
Medication: Paracetamol	1.5	2.4	7.1	-2.5	2.3	-0.4	1.5	-1.8	0.1	-1.0	-0.9	1.2	2.7	1.8	1.1
Hypothyroidism/myxoedema (self-reported)	1.5	2.9	8.4	0.5	0.3	2.2	-0.6	-1.3	-2.9	-2.3	-2.8	0.5	-2.3	-1.1	-1.5
Medication for pain relief, constipation, heartburn	1.5	2.6	9.5	3.0	-3.1	0.0	-0.8	2.0	-0.7	1.0	1.0	-0.9	-2.1	-1.6	0.1
Medication: Allopurinol	1.5	2.0	10.4	1.8	1.6	2.7	0.2	0.3	-0.6	-0.0	-0.3	3.2	0.0	-0.1	1.3
Medication: Omeprazole	1.5	1.8	8.2	-1.7	2.9	0.8	1.5	-0.6	0.1	-0.5	0.0	1.2	2.0	1.5	1.1
Qualifications: NVQ or HND or HNC or equivalent	1.5	1.8	6.3	1.7	0.7	2.5	0.7	1.9	0.8	0.9	0.7	2.3	-0.8	-1.1	-0.3
Hypertension (Self-reported)	1.5	4.3	12.2	-1.3	2.3	2.8	0.4	-2.0	-3.5	-2.9	-3.0	2.4	0.2	-0.1	0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.5	1.7	5.0	-1.0	1.8	-2.2	0.3	-0.0	2.1	0.7	1.0	-0.1	1.1	2.2	-1.0
Long-standing illness, disability or infirmity	1.5	2.2	8.8	0.9	0.2	2.6	-0.6	0.1	-1.9	-0.7	-1.5	0.9	-1.4	-3.0	-1.8
Number of self-reported non-cancer illnesses	1.5	2.6	9.9	-0.5	0.8	1.0	-0.4	-1.8	-3.0	-2.9	-3.1	-0.1	0.5	-0.2	-1.0
Medication: Levothyroxine sodium	1.4	2.4	7.1	1.1	-0.6	1.0	-1.3	-1.3	-2.5	-1.9	-2.7	-0.3	-2.2	-1.0	-1.5
Illnesses of mother	1.4	1.7	4.9	-0.2	-1.2	-2.2	-0.7	0.8	2.2	1.6	1.7	-1.2	-1.5	0.0	-1.0
Birth weight of first child	1.4	2.5	8.8	-0.7	0.2	-0.8	2.6	0.7	1.0	0.9	1.1	-1.3	2.7	3.0	1.7
Pulse wave reflection index	1.4	1.7	5.0	-2.2	0.9	0.5	-0.1	-1.9	-1.8	-2.1	-1.9	0.9	0.3	-0.5	-0.3
Loneliness, isolation	1.4	1.9	5.6	-0.3	-0.6	-0.5	-1.6	1.7	2.3	2.3	2.4	-0.4	1.2	0.5	-1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.4	3.0	11.0	-2.8	1.9	1.3	1.3	-1.2	1.3	-0.1	0.1	1.2	3.3	2.5	1.4
Unable to work because of sickness or disability	1.4	1.8	8.1	-0.1	-1.0	1.0	-1.1	1.0	-0.1	0.5	0.1	0.2	-2.7	-1.8	-2.8
Medication: Omeprazole (e.g. Zanprol)	1.4	1.7	10.0	-1.2	3.2	1.2	1.2	0.2	1.1	0.3	0.6	1.4	1.5	1.1	0.5
Maternal smoking around birth	1.3	1.9	7.7	0.4	-0.8	0.0	-1.9	0.5	-1.2	-0.2	-0.9	-0.7	-2.4	-2.8	-1.9
Supplements: Glucosamine	1.3	1.6	4.7	0.5	-0.3	0.0	-1.9	1.6	2.2	1.9	2.1	-0.4	0.4	-1.2	-0.0
Ever unenthusiastic/disinterested for a whole week	1.3	1.6	7.8	-1.1	0.6	0.2	1.1	-0.6	0.9	-0.1	0.2	2.8	2.0	1.6	1.4
Weight	1.3	6.6	21.1	3.5	-1.6	-0.4	-2.4	3.4	-0.6	1.3	0.1	-1.1	-4.6	-3.0	-4.5
Depression (self-reported)	1.3	1.6	4.6	-0.6	0.5	-0.6	1.0	0.7	2.0	1.6	1.8	0.0	1.9	2.1	0.9
Osteoarthritis (self-reported)	1.3	1.7	5.4	1.7	-0.2	1.8	-2.3	0.8	-1.0	0.0	-0.4	-1.1	-1.8	-1.7	-1.4
Guilty feelings	1.3	2.0	9.8	-1.5	1.2	1.1	0.7	-0.6	0.7	-0.0	0.3	1.3	3.1	2.4	1.4
Mother’s age at death	1.3	1.6	6.9	-1.7	-0.7	-2.6	-2.0	-1.8	-0.0	-0.9	-0.9	-0.9	-0.0	-0.6	-0.4
Medication: Bendroflumethiazide	1.3	1.9	9.3	-1.0	3.1	1.1	1.5	-0.7	0.8	0.2	0.3	2.8	0.6	0.4	1.5
Frequency of depressed mood in last 2 weeks	1.2	1.7	6.5	-2.2	0.9	0.5	0.7	-1.1	1.2	0.2	0.4	1.9	2.5	1.3	0.9
Hearing difficulty/problems: Yes	1.2	1.8	6.5	-2.2	0.2	1.3	-0.8	-2.5	-1.1	-1.9	-1.8	0.1	0.6	-0.7	-0.7
Chronic bronchitis/emphysema (father)	1.2	1.5	5.1	0.1	-1.3	-2.1	-1.2	-0.2	0.3	0.1	-0.6	-1.5	-0.9	-1.7	-2.3
Mouth/teeth dental problems: Loose teeth	1.2	1.5	5.3	0.6	-2.3	-2.1	-0.6	0.8	0.7	1.2	1.3	-1.7	0.7	0.9	-0.4
Ever had stillbirth, spontaneous miscarriage or termination	1.2	1.3	4.0	1.1	-0.4	0.1	0.2	1.6	1.3	2.0	2.0	0.1	0.8	0.6	1.2
Eye problems/disorders: Cataract	1.2	1.4	5.5	-0.0	0.6	1.3	0.8	-1.3	-2.3	-1.9	-1.6	0.2	0.2	0.9	1.3
Mineral and other dietary supplements	1.2	1.6	7.8	1.0	-0.0	0.5	-0.5	0.2	-1.3	-0.8	-1.3	1.4	-2.8	-1.9	-1.6
Medication: Gliclazide	1.2	1.4	5.4	-0.7	2.3	1.5	0.4	-0.6	-0.3	-1.0	-0.7	2.3	-1.0	-0.8	-0.8
Vascular/heart problems diagnosed by doctor	1.2	3.1	10.4	0.6	-2.1	-2.1	-0.7	1.8	3.2	2.6	2.8	-1.6	-0.2	-0.2	-0.3
Ulcerative Colitis (UC)	1.1	2.0	9.7	-3.1	1.1	-0.8	1.5	-2.3	-0.1	-1.6	-1.4	1.6	0.1	-0.1	-0.3
Major Depression (MDD)	1.1	1.3	3.8	-0.0	0.8	-0.4	0.8	1.3	1.9	1.6	1.8	0.2	0.3	1.7	0.9
Age at First Birth	1.1	1.6	7.5	0.1	-0.6	-2.7	0.6	0.4	1.3	0.7	1.1	-1.5	1.2	1.8	1.2
Relative age of first facial hair	1.1	2.3	7.5	1.5	-0.1	0.0	-2.3	1.8	1.3	1.5	1.3	-1.1	-2.7	-1.2	-1.8
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.4	4.6	-0.4	0.3	-0.0	-0.1	0.8	2.1	1.5	1.8	1.0	1.9	1.6	0.4
Tinnitus: Yes, but not now, but have in the past	1.1	1.2	4.7	0.3	0.6	-0.5	0.8	-0.3	-0.2	-0.1	0.0	0.5	2.2	2.0	2.2
Waist circumference	1.1	4.0	14.0	1.8	-0.9	0.0	-1.8	2.7	-0.0	1.5	0.5	-1.1	-3.4	-2.9	-3.7
Neuroticism score	1.1	2.3	12.4	-1.9	-0.4	1.0	1.0	-1.0	1.2	0.2	0.5	1.4	3.5	2.3	1.3
Worrier / anxious feelings	1.1	2.1	10.0	-1.3	-0.5	-0.5	2.0	-1.5	0.5	0.0	0.2	-1.0	3.2	1.8	2.2
Falls in the last year	1.1	1.5	5.8	0.4	2.3	2.4	0.6	0.1	-0.1	0.3	0.5	2.3	1.0	1.1	0.9
Noisy workplace	1.1	1.3	7.0	-0.5	0.3	2.6	0.7	-0.2	-1.4	-0.9	-0.8	2.4	0.1	-0.3	-0.1
Ever highly irritable/argumentative for 2 days	1.1	1.3	4.7	0.5	-1.0	-0.6	-0.9	1.4	2.2	1.8	1.9	-0.7	0.3	-0.4	-0.3
Neck or shoulder pain in last month	1.1	1.5	3.8	-0.5	1.9	1.2	-0.1	0.9	1.8	1.6	1.7	1.8	0.6	0.6	0.6
Medication: Blood pressure	1.1	1.9	4.7	-1.5	1.7	1.0	-0.0	-2.1	-2.2	-1.9	-2.0	1.2	0.2	-0.3	0.2
Supplements: Vitamin C	1.1	1.3	6.2	-0.8	-0.5	-0.6	1.2	-0.4	1.7	0.8	1.1	-0.2	2.5	1.4	1.2
Asthma (self-reported)	1.1	2.2	7.4	1.5	-1.8	2.0	-0.9	-0.2	-1.8	-1.1	-1.4	-1.1	-1.5	-2.7	-1.0
Severe depression (siblings)	1.0	1.1	3.8	0.6	0.1	0.5	-0.5	1.7	1.3	1.8	1.9	-0.2	0.2	0.9	0.8
Medication: Atenolol	1.0	1.3	3.5	0.2	-0.0	1.1	-1.2	-0.3	-1.5	-0.8	-1.5	1.2	-1.5	-1.9	-1.2
Qualifications: None of the above	1.0	2.2	9.9	-2.0	1.8	0.0	-1.2	-0.7	-0.4	-0.5	-1.0	-0.2	-2.8	-0.1	-3.2
Asthma	1.0	2.0	6.0	2.1	-2.1	1.8	-0.7	0.2	-1.2	-0.6	-0.9	-0.7	-1.7	-2.5	-0.9
Chronic bronchitis/emphysema (mother)	1.0	1.2	5.5	1.7	-2.4	-1.8	-0.7	0.5	-0.4	0.1	-0.3	-1.2	0.1	-1.1	0.3
Migraine (self-reported)	1.0	1.2	3.6	-0.8	0.9	1.7	0.4	-1.3	-1.6	-1.9	-1.9	0.2	-0.2	0.2	-0.3
Medication: Ibuprofen	1.0	1.2	5.2	0.2	0.4	0.0	0.7	0.9	2.3	1.5	1.7	0.9	1.7	0.4	0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	3.8	-1.0	0.6	0.9	-0.6	-1.9	-0.6	-1.4	-1.3	1.1	-1.3	-1.2	-0.7
Overall health rating	1.0	2.1	10.9	0.2	0.2	0.1	-1.3	0.1	-0.1	0.2	-0.6	0.3	-2.7	-2.5	-3.3
Knee pain experienced in last month	1.0	1.6	4.5	0.7	-0.3	2.0	-2.1	0.5	-0.8	0.1	-0.4	-0.2	-1.7	-2.1	-1.9
Medication for cholesterol	1.0	1.6	5.1	0.7	-2.1	-2.0	-0.5	0.7	2.3	1.3	1.4	-1.3	0.0	-0.4	-0.4
Back pain experienced in last month	1.0	1.5	8.2	-1.6	2.9	1.1	0.9	0.2	0.9	0.4	0.7	2.2	0.1	-0.4	-0.2
Medication: Lisinopril	1.0	1.3	4.3	-1.7	1.3	0.6	-0.6	-2.1	-1.1	-1.5	-1.4	1.1	0.3	-0.2	-0.4
Ever smoked	1.0	1.8	7.1	-2.7	1.5	-0.3	-0.4	-1.5	1.5	-0.3	0.1	1.1	1.9	1.7	1.0
Irritable Bowel Disease (IBD)	0.9	2.1	9.1	-3.0	0.7	-1.4	2.0	-2.3	0.2	-1.4	-0.9	1.2	0.9	0.8	0.8
Verbal and Numeric Reasoning (VNR)	0.9	2.2	7.9	2.8	-1.9	0.9	-0.6	0.0	-2.5	-0.5	-0.8	-0.3	-1.6	-2.5	0.6
Number of treatments/medications taken	0.9	1.6	4.9	-1.0	2.2	1.4	0.1	-1.0	-2.1	-1.2	-1.6	-0.3	-0.5	-1.3	-1.1
Leg fat-free mass (left)	0.9	4.5	11.9	3.5	-1.7	-0.9	-2.4	3.1	-0.9	1.1	-0.0	-1.6	-2.9	-1.9	-3.3
Taking other prescription medications	0.9	1.4	3.9	-0.8	0.8	0.4	0.3	-0.8	-1.9	-1.6	-2.0	-1.4	-0.9	-0.5	-1.9
High blood pressure (mother)	0.9	1.2	3.4	1.3	0.9	1.5	1.1	0.8	-0.1	0.3	0.3	1.8	1.6	0.7	1.5
Leg predicted mass (left)	0.9	4.6	12.0	3.5	-1.8	-0.9	-2.4	3.1	-0.9	1.1	0.0	-1.6	-2.9	-1.9	-3.4
Number of incorrect matches in round	0.9	1.5	3.2	-1.6	1.8	0.6	1.8	-1.3	-0.7	-1.3	-1.3	0.0	1.1	1.7	1.0
Alcohol usually taken with meals	0.9	1.5	6.8	0.4	-0.6	-0.6	-2.6	0.4	0.5	0.6	0.3	-0.6	-2.5	-1.9	-1.0
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.4	4.6	-0.6	-1.1	-0.9	-0.5	0.1	1.9	1.5	1.6	0.3	2.2	1.6	0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.1	6.6	2.6	-1.5	0.4	-0.3	0.7	-2.2	-0.6	-1.0	-1.3	-2.2	-2.2	-0.1
Medication for cholesterol, blood pressure or diabetes	0.9	1.4	4.7	1.3	-0.8	0.1	-0.3	2.2	1.9	1.8	2.0	-0.4	0.2	0.5	0.3
Medication: Amlodipine	0.9	1.2	3.2	-0.7	1.0	0.6	-1.1	-1.4	-1.8	-1.4	-1.8	1.0	-0.6	-0.8	-0.7
Shortness of breath walking on level ground	0.9	1.0	4.5	2.1	-1.3	1.3	-0.8	1.0	0.0	0.6	0.1	0.3	-0.3	-1.5	-0.9
Illnesses of siblings: Diabetes	0.9	1.1	4.1	0.1	0.5	1.2	0.7	-0.3	-2.0	-1.0	-1.3	0.6	-1.4	-1.1	-1.0
Miserableness	0.9	1.6	5.0	-1.6	-0.5	-0.1	-0.6	-0.3	2.2	1.1	1.4	1.5	1.7	1.8	0.1
Myopia	0.9	1.3	6.5	1.4	0.1	0.3	-1.3	-0.1	-1.2	-0.6	-0.9	-0.4	-1.8	-2.5	0.2
Arm predicted mass (left)	0.9	4.4	12.9	2.9	-1.8	-1.5	-2.0	2.9	-0.5	1.2	0.1	-1.6	-3.2	-1.9	-3.6
Breast Cancer	0.8	2.0	6.0	1.5	-1.0	1.9	-1.9	0.2	-0.9	-0.1	-0.6	-1.7	-2.4	-1.1	-1.9
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	3.0	-0.1	-0.3	0.8	-0.1	-0.5	-1.4	-0.9	-1.2	-1.7	-0.4	0.3	-1.7
Vitamin and mineral supplements	0.8	1.1	3.4	-0.1	1.1	1.2	0.2	-0.3	-1.8	-1.4	-1.5	1.7	-0.7	-0.7	0.1
Diverticular disease/diverticulitis (self-reported)	0.8	1.0	3.1	1.2	-0.0	-0.9	-1.8	1.0	-0.2	0.3	0.0	-1.1	-0.9	-1.4	-1.6
Had other major operations	0.8	1.0	3.2	-1.0	0.2	-0.7	-1.3	-0.7	-0.5	-0.2	-0.7	-1.7	-0.8	-1.1	-1.8
Heart attack	0.8	1.0	5.9	0.3	-0.4	-2.4	-0.1	0.7	0.9	1.0	0.8	-0.3	-1.1	-0.2	-1.8
Illnesses of siblings	0.8	1.2	4.7	0.8	-0.8	-1.6	-0.9	0.9	2.2	1.3	1.6	-0.3	0.1	0.5	0.2
Number of live births	0.8	1.1	4.1	-1.3	0.2	0.1	-0.7	-0.5	-0.7	-0.9	-0.9	0.8	-1.4	-1.6	-2.0
Serious illness, injury or assault of a close relative in last 2 years	0.8	1.0	3.5	1.9	-1.6	-0.1	0.5	0.9	0.4	0.6	0.6	-0.3	1.6	1.1	0.8
Lung cancer (father)	0.8	1.0	4.9	0.6	0.3	1.2	-0.2	0.8	-1.5	-0.1	-0.6	-1.0	-2.2	-0.7	-1.0
Qualifications: O levels/GCSEs or equivalent	0.8	1.3	5.4	0.8	-1.7	-0.5	1.2	0.1	-0.1	0.2	0.7	-0.3	2.2	1.1	2.3
Medication: Ventolin 100micrograms inhaler	0.8	1.0	2.8	1.4	-1.7	0.9	-1.3	-0.1	-0.3	-0.6	-0.9	-0.4	-1.2	-1.3	-1.0
Arm fat-free mass (right)	0.8	4.0	11.9	2.8	-1.8	-1.2	-1.9	2.8	-0.7	1.0	-0.1	-1.5	-3.2	-1.6	-3.5
Arm predicted mass (right)	0.8	4.2	13.1	2.5	-2.0	-1.5	-2.1	2.5	-0.8	0.8	-0.3	-1.7	-3.4	-1.7	-3.6
Age at last live birth	0.8	1.2	3.2	-0.5	0.0	-1.7	1.7	-0.3	0.2	0.4	0.5	0.9	1.7	1.2	1.8
Leg pain on walking	0.8	1.0	4.6	-1.0	-0.5	0.6	-0.2	-0.8	-0.1	-0.8	-1.1	0.8	-1.9	-0.5	-2.1
Friendships satisfaction	0.8	0.9	3.5	-1.2	-0.3	-1.1	-0.1	-0.9	0.5	-0.5	-0.1	0.2	1.5	1.6	1.9
Medication: Paracetamol	0.8	1.2	3.9	-1.8	2.0	-0.6	1.0	-1.2	0.2	-0.4	-0.3	-0.1	1.9	0.9	0.9
Alcohol drinker status: Never	0.8	1.0	3.0	1.7	0.4	-0.7	0.3	1.6	1.0	1.3	1.2	-1.6	-0.1	0.3	0.0
Arm fat-free mass (left)	0.8	3.8	11.0	2.9	-2.0	-1.4	-1.8	2.7	-0.5	1.1	0.1	-1.5	-2.8	-1.5	-3.3
Number of operations (self-reported)	0.8	1.2	3.1	-1.6	0.9	0.5	0.5	-1.5	-1.6	-1.6	-1.8	-0.8	0.2	-0.5	-0.3
Pain experienced in last month	0.8	1.3	4.2	1.9	-1.7	-2.0	-0.6	0.4	-0.4	-0.2	-0.4	-2.0	-1.1	-0.3	-0.5
Alzheimer’s Disease (in father)	0.7	0.8	4.0	0.7	0.2	2.0	-1.0	0.8	0.3	0.9	0.8	-0.7	0.3	-1.2	0.0
Other serious medical condition/disability diagnosed by doctor	0.7	1.0	3.6	0.3	0.7	1.6	0.9	-0.5	-1.9	-1.0	-1.4	0.4	0.1	-1.2	-0.2
Fed-up feelings	0.7	1.3	5.0	-0.3	-0.4	0.4	-1.1	1.1	2.2	1.6	1.5	0.1	1.0	0.6	-1.5
Forced vital capacity (FVC)	0.7	2.8	17.1	-2.3	1.8	0.4	0.9	-1.0	-0.5	-0.8	-0.6	-0.5	4.1	1.8	2.1
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	2.8	-0.9	-0.2	0.4	0.6	-1.7	-1.1	-1.3	-1.3	0.3	1.1	-0.6	-1.1
Impedance of arm (right)	0.7	3.4	16.3	-1.3	2.7	1.0	2.2	-0.9	0.0	-0.7	0.0	1.4	4.0	1.9	2.6
Impedance of arm (left)	0.7	3.0	11.9	-1.2	2.7	1.4	2.1	-0.4	0.3	-0.4	0.2	1.9	3.5	1.6	2.3
Breastfed as a baby	0.7	0.9	4.6	-1.0	-0.1	-2.1	0.6	0.2	1.5	1.0	1.2	-0.4	0.5	-0.1	0.4
Tense / ‘highly strung’	0.7	1.2	6.5	-0.7	0.5	1.0	0.8	-1.1	0.1	-0.2	-0.1	1.0	2.6	1.6	1.2
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	2.9	-0.4	-0.4	0.1	-0.2	0.9	0.3	1.3	1.5	-1.1	1.7	1.3	1.0
Forced vital capacity (FVC), Best measure	0.7	2.6	11.1	-3.0	1.3	0.2	0.9	-1.7	-0.2	-1.0	-0.8	0.6	3.3	2.2	1.1
Exposure to tobacco smoke outside home	0.7	0.9	2.8	1.1	0.9	1.1	-0.1	1.7	0.7	1.5	1.1	0.0	0.0	-1.0	-0.8
Mean time to correctly identify matches	0.7	1.4	4.9	-1.8	0.9	-1.0	0.7	-2.2	-1.2	-1.6	-1.4	-0.3	0.9	0.7	0.9
Commuting to job workplace: Car/motor vehicle	0.7	0.9	2.4	-0.5	0.0	1.5	-0.7	-0.3	-0.3	-0.6	-0.6	1.1	-1.2	-1.5	-1.4
Leg fat-free mass (right)	0.7	3.7	10.8	3.0	-1.3	-0.6	-2.1	2.9	-1.0	0.9	-0.1	-1.4	-2.7	-1.5	-3.3
Handedness (chirality/laterality): Left-handed	0.7	0.9	2.8	-1.0	-0.6	-1.7	0.9	-0.2	1.4	0.4	0.7	0.3	1.3	1.1	0.9
Illnesses of father: None of the above (group 1)	0.7	0.8	4.4	-2.1	1.1	0.5	1.0	-0.4	0.1	-0.5	-0.0	1.6	-0.3	0.5	0.1
Leg predicted mass (right)	0.7	3.6	10.5	2.9	-1.4	-0.7	-2.1	2.8	-0.9	0.9	-0.1	-1.4	-2.6	-1.5	-3.2
Hearing aid user	0.7	0.8	3.0	-1.2	1.0	-0.0	1.4	-1.7	-0.6	-1.1	-0.8	-0.6	0.8	0.1	0.2
Tinnitus: Yes, now most or all of the time	0.7	0.8	2.6	-1.6	0.5	0.6	1.3	-1.0	-0.1	-0.3	-0.1	-0.4	1.5	1.0	0.7
Basal metabolic rate	0.7	4.1	11.9	2.9	-1.8	-1.5	-2.0	2.9	-0.7	1.0	-0.1	-1.7	-2.8	-1.7	-3.5
Irritability	0.7	1.2	2.9	1.1	0.1	1.7	0.3	1.1	1.6	1.4	1.2	1.2	-0.4	-0.8	-1.3
Heart attack/myocardial infarction (self-reported)	0.7	0.9	4.8	0.4	-0.4	-2.2	-0.1	0.7	0.8	1.0	0.7	0.1	-1.0	-0.1	-1.6
Depressed Affect (Nagel 2018)	0.6	1.2	4.1	-1.5	-0.3	0.3	-1.2	0.3	2.0	1.0	1.2	0.5	1.6	0.9	-1.3
Neuroticism (Nagel 2018)	0.6	1.4	4.8	-1.1	0.5	1.2	0.2	-0.3	2.0	0.8	1.0	1.2	2.2	1.7	0.4
Ovarian Cancer	0.6	0.8	3.6	-1.5	-1.0	-0.2	-0.4	-0.1	-0.2	-0.5	-0.5	-0.5	-0.7	-1.5	-1.9
Medication: Co-codamol	0.6	0.7	2.3	0.3	-1.0	-0.9	-0.0	1.0	0.9	1.5	1.4	0.1	-0.0	0.1	-0.5
Townsend deprivation index at recruitment	0.6	0.9	4.2	-1.2	1.7	0.7	0.2	-0.4	1.2	0.1	0.1	2.1	0.2	0.7	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.3	3.6	1.9	-1.1	0.5	0.5	0.2	-1.9	-0.8	-1.1	-0.4	-1.7	-1.7	0.5
Past tobacco smoking	0.6	1.1	4.1	2.0	-0.9	0.7	1.3	1.2	-2.0	-0.4	-0.5	-0.8	-0.7	-0.7	-0.0
Mouth/teeth dental problems	0.6	1.0	3.5	-0.5	0.0	0.8	1.0	-1.0	-1.9	-1.7	-1.7	-0.6	-0.0	0.1	0.7
Medication: Simvastatin	0.6	0.8	3.2	-0.1	0.7	-0.7	-0.5	-0.3	-1.1	-0.7	-1.0	-0.9	-1.8	-0.3	-1.5
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	2.7	-1.2	-0.8	-1.0	1.1	0.3	1.0	0.9	1.2	-0.1	1.7	1.5	0.3
Pulse wave Arterial Stiffness index	0.6	0.7	2.3	-1.5	1.2	-0.3	0.6	-0.6	0.3	-0.6	-0.2	0.9	1.4	1.0	0.2
Loud music exposure frequency	0.6	0.7	1.8	0.3	1.1	1.3	0.6	0.1	0.3	0.2	0.3	1.3	1.4	0.9	0.8
Glaucoma (self-reported)	0.6	0.7	3.4	-1.0	0.6	-1.9	-0.8	0.2	0.1	0.4	0.5	-1.4	0.3	0.9	0.5
Number of children fathered	0.6	0.7	3.6	0.0	-0.8	-1.2	0.3	0.2	0.2	0.3	0.3	-0.7	1.9	0.8	1.2
Health satisfaction	0.6	0.8	3.0	-0.3	0.1	-0.6	-0.7	-0.5	0.6	-0.2	-0.4	1.7	-1.3	-1.6	-1.4
Qualifications: College or University degree	0.6	1.8	9.3	-0.1	-0.9	-1.1	1.0	-1.8	0.4	-0.4	0.3	0.7	2.6	-0.4	3.0
Angina (self-reported)	0.6	0.8	5.2	2.3	1.5	0.2	0.5	1.1	-0.2	0.6	0.4	-0.5	-0.6	0.7	0.6
Smoking status: Previous	0.6	0.9	4.1	-1.2	0.2	-1.0	-1.5	-1.0	2.0	0.5	0.6	1.2	-0.2	0.6	-0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.3	6.2	1.6	-2.5	-1.7	0.5	1.4	-0.5	0.6	0.3	-0.4	1.0	1.0	-0.1
Whole body fat-free mass	0.6	3.5	9.4	2.7	-1.9	-1.6	-1.9	2.6	-0.8	0.9	-0.2	-1.8	-2.4	-1.3	-3.1
Qualifications: nursing, teaching	0.6	0.9	3.5	0.2	-1.4	-1.0	1.2	-0.9	-0.3	-0.6	-0.4	0.3	1.5	-0.2	1.9
Osteoporosis (self-reported)	0.6	0.7	2.1	-0.5	-1.3	0.5	-1.2	-0.2	-0.4	-0.3	-0.5	-0.3	-1.4	-1.0	-1.4
Bipolar Disorder (2018)	0.5	0.9	2.8	-1.7	1.4	0.3	0.7	-0.6	0.4	-0.3	0.0	1.4	0.7	1.4	0.9
Crohns Disease (2017)	0.5	1.0	2.9	-1.0	-0.0	-1.4	1.5	-0.7	1.0	0.1	0.5	0.0	1.3	1.7	1.3
Sensitivity / hurt feelings	0.5	0.8	2.9	-1.7	-1.2	-1.3	-0.4	-0.7	1.5	0.3	0.3	-0.3	-0.1	0.4	-1.0
Systolic blood pressure, automated reading	0.5	1.6	6.6	1.2	-0.7	0.1	-1.1	0.3	-1.1	-0.6	-1.2	0.2	-2.6	-1.9	-2.0
Angina	0.5	0.6	3.8	2.0	1.5	0.3	0.4	0.8	-0.4	0.4	0.1	-0.3	-0.5	0.5	0.3
Multivitamins +/- minerals	0.5	0.7	2.3	-0.1	0.3	-1.0	0.1	0.1	1.5	0.9	1.1	-1.0	0.5	1.5	0.2
Had menopause	0.5	0.7	2.7	1.1	-1.2	0.7	-0.6	0.4	-0.2	0.2	0.0	0.3	-1.6	-1.3	-0.7
Hair/balding pattern: Pattern 3	0.5	0.7	1.8	-1.2	0.4	1.4	0.3	-1.4	-1.1	-1.2	-1.0	0.4	-0.4	-0.4	0.5
Qualifications: A levels/AS levels or equivalent	0.5	1.1	5.6	1.2	-1.1	-1.5	0.7	0.2	-0.2	0.5	0.6	-0.3	1.4	-0.1	2.4
Pulse wave peak to peak time	0.5	0.6	2.5	1.6	-1.0	0.4	-0.5	0.7	-0.4	0.5	0.2	-0.7	-1.3	-0.8	-0.2
Medication: Aspirin	0.5	0.7	2.6	-0.3	0.9	0.4	0.2	-1.0	-1.3	-1.3	-1.6	-0.2	-0.6	0.1	-0.8
Illnesses of father: Heart disease	0.5	0.7	2.4	1.5	-0.8	-1.1	-1.6	0.2	0.7	0.5	0.2	0.1	-0.9	-0.9	-0.8
Ever had bowel cancer screening	0.5	0.6	2.8	0.1	0.3	-1.3	-0.3	0.6	1.7	1.1	0.9	-0.7	0.2	0.3	-0.9
Diabetes diagnosed by doctor	0.5	0.8	2.9	0.9	-0.2	1.0	-0.4	-0.3	-1.1	-0.5	-0.8	0.9	-0.8	-1.7	-1.1
Commuting to job workplace: Walk	0.5	0.5	2.5	0.4	-0.0	-1.6	-1.5	-0.5	0.1	-0.2	-0.3	0.2	-0.9	0.2	-0.4
Breast cancer (self-reported)	0.5	0.6	1.8	-1.0	0.8	0.9	-0.0	-0.8	-0.4	-0.4	-0.6	1.3	0.1	-1.4	-0.3
Whole body water mass	0.5	3.1	8.3	2.6	-1.8	-1.6	-1.8	2.5	-0.8	0.8	-0.2	-1.8	-2.1	-1.0	-2.9
Commuting to job workplace: Public transport	0.5	0.6	4.1	0.3	-0.1	-2.0	0.1	0.4	0.2	0.3	0.3	-0.6	1.1	0.1	1.0
Eye problems/disorders: Glaucoma	0.5	0.5	2.4	-1.0	-0.1	-1.5	-0.7	-0.3	-0.9	-0.0	-0.1	-1.5	0.2	-0.0	0.3
Average weekly beer plus cider intake	0.5	0.7	4.5	0.1	-0.8	-0.5	-0.1	0.9	-0.1	0.8	0.9	-2.1	0.5	1.0	-0.7
Impedance of whole body	0.5	2.6	8.9	-1.5	2.5	1.4	1.9	-0.7	0.8	-0.2	0.4	2.0	3.0	1.2	2.0
Alzheimer’s Disease (in mother)	0.4	0.5	1.4	-0.6	0.5	0.5	-0.6	-0.9	-1.0	-1.2	-1.2	-0.4	0.4	-0.0	-0.8
Reaction Time	0.4	0.8	2.5	-1.3	0.8	-0.9	0.5	-1.6	-0.5	-0.9	-0.8	-0.6	1.0	0.6	1.1
Medication for hormone replacement therapy	0.4	0.4	1.6	-0.4	-0.0	-1.1	-1.0	0.2	1.3	0.7	0.5	0.3	0.3	0.7	-0.2
Impedance of leg (right)	0.4	1.8	6.0	-2.0	1.5	0.2	1.6	-1.5	0.8	-0.5	0.1	1.6	2.5	0.8	1.7
Age when periods started (menarche)	0.4	1.0	2.8	-0.3	0.8	-0.5	1.1	-0.7	-1.6	-0.8	-1.1	0.3	1.6	0.6	1.7
Serious illness, injury or assault to yourself	0.4	0.4	1.1	0.1	1.1	0.1	1.0	0.5	0.7	0.7	0.7	0.9	0.2	0.8	0.1
Impedance of leg (left)	0.4	2.1	5.3	-2.3	2.1	0.7	1.9	-1.6	0.8	-0.6	0.0	1.5	2.2	1.0	1.5
Financial difficulties in last 2 years	0.4	0.5	2.0	-0.3	-0.0	0.5	0.3	0.9	1.4	0.9	1.3	0.8	-0.2	0.6	-0.2
Fluid intelligence score	0.4	0.9	3.6	1.9	-1.6	0.5	-0.1	-0.9	-1.2	-0.6	-0.5	0.2	-0.0	-0.7	1.3
Trunk fat-free mass	0.4	2.3	5.6	2.0	-1.9	-2.2	-1.4	2.0	-0.7	0.6	-0.3	-1.8	-1.4	-0.7	-2.4
Alcohol intake versus 10 years previously	0.4	0.7	1.7	-1.3	1.1	1.1	0.5	-0.9	-1.0	-0.8	-0.9	0.7	0.1	0.5	-0.4
Medication: Cholesterol lowering	0.4	0.6	1.4	0.4	0.5	-0.9	0.2	-0.9	-1.0	-0.8	-1.2	-0.5	-1.0	-0.3	-1.0
Trunk predicted mass	0.4	2.4	5.5	2.0	-1.8	-2.2	-1.3	2.0	-0.7	0.6	-0.3	-1.8	-1.4	-0.7	-2.3
Hair/balding pattern: Pattern 4	0.4	1.0	3.6	1.3	-1.2	-0.2	-0.7	1.6	0.2	1.1	1.0	-1.9	1.0	0.3	0.0
Birth weight	0.4	0.8	4.1	-0.9	-1.0	-0.6	0.3	0.5	1.0	0.8	0.9	-0.0	2.0	1.3	-0.1
High blood pressure (siblings)	0.4	0.5	1.6	-0.9	0.6	1.3	0.9	-0.5	-1.2	-0.6	-0.7	0.5	0.2	0.1	0.1
Number of full brothers	0.4	0.5	1.6	0.2	-1.2	-1.3	-0.8	0.2	0.4	0.2	-0.1	-0.5	-0.7	-0.7	-1.0
Had major operations	0.4	0.5	2.1	0.3	0.1	-1.5	-1.0	0.0	-0.4	-0.0	-0.3	-1.0	-0.5	-0.9	-0.9
Mood swings	0.4	0.7	2.2	-0.6	-1.1	1.5	-0.0	0.3	0.9	0.7	0.6	0.8	1.3	-0.2	-0.8
Medication: Aspirin	0.4	0.6	2.2	0.1	0.6	0.9	0.0	-0.6	-1.5	-1.0	-1.3	-0.1	-0.6	-0.1	-0.7
Ever taken oral contraceptive pill	0.4	0.5	1.4	1.2	0.4	0.9	0.6	0.8	-0.5	0.5	0.6	0.6	0.3	0.9	1.0
Pain type(s) experienced in last month: Hip pain	0.4	0.5	2.8	-0.3	1.1	1.7	0.9	0.1	-0.6	-0.4	-0.5	0.4	-0.7	-0.1	-0.3
Medication: Atorvastatin	0.4	0.5	2.9	1.0	-0.4	-0.3	1.7	-0.6	-0.9	-0.6	-0.8	-0.4	0.5	0.1	0.3
Alcohol drinker status: Previous	0.4	0.4	1.3	0.6	-0.3	-1.1	0.1	-0.7	0.6	0.2	0.4	0.1	0.8	1.0	0.9
Schizophrenia vs Biploar Disorder	0.3	0.4	1.8	-1.3	-0.1	-0.4	0.2	-0.4	-0.2	-0.4	-0.2	-0.8	1.3	0.7	0.2
Alzheimer’s Disease (including proxy)	0.3	0.4	3.8	-0.2	0.1	2.0	-0.1	0.1	-0.3	-0.2	-0.1	-1.0	0.3	-0.4	0.0
Diabetes (father)	0.3	0.3	2.2	0.7	-0.1	1.5	-0.2	-0.0	-0.3	-0.2	-0.4	0.4	0.6	-0.9	-0.3
Pack years adult smoking proportion	0.3	0.4	2.5	0.0	-0.4	1.0	0.1	0.1	-1.6	-0.7	-0.9	-0.3	0.0	-0.5	0.1
Hand grip strength (right)	0.3	0.8	1.7	1.1	-0.7	-1.3	-0.4	1.0	0.9	0.9	0.3	-0.4	-0.8	-0.9	-1.3
Relative age voice broke	0.3	0.5	2.1	0.9	-0.4	1.1	-0.2	0.9	-0.1	0.3	0.4	-1.5	-0.3	-0.9	0.1
Hair/balding pattern: Pattern 2	0.3	0.4	1.5	-0.0	0.2	-1.2	0.2	-0.5	1.1	0.0	0.1	1.1	-0.5	0.6	-0.2
Diabetes (self-reported)	0.3	0.5	1.7	0.5	-0.6	1.0	-0.7	-0.2	-1.1	-0.4	-0.6	0.6	-0.4	-1.3	-0.6
Medication: Ramipril	0.3	0.4	1.5	0.3	-0.1	0.1	-0.6	-0.7	-0.5	-0.8	-1.2	0.1	-1.0	-1.0	-0.1
Blood clot in the leg (DVT)	0.3	0.4	1.9	-0.0	0.8	-1.0	0.1	0.3	0.9	0.5	0.4	-0.3	0.7	-0.3	-1.4
Worry too long after embarrassment	0.3	0.5	1.5	-1.0	-1.2	0.3	-0.7	-1.1	-0.2	-0.2	-0.3	-0.7	-0.8	-0.7	-0.1
Wheeze or whistling in the chest in last year	0.3	0.6	2.9	0.5	-0.9	-0.3	-1.1	0.5	0.9	0.5	0.3	-0.3	-0.3	-0.9	-1.7
Medication: Seretide 50 evohaler	0.3	0.3	1.1	-0.1	-0.9	0.5	0.5	-0.3	-0.6	-0.8	-1.1	0.0	-0.6	0.5	-0.3
Alcohol intake frequency.	0.3	0.8	4.9	-0.3	2.2	0.6	0.7	0.3	-0.5	-0.0	-0.2	0.2	-1.0	0.5	-1.5
Number of full sisters	0.3	0.3	1.1	-0.8	0.7	-0.2	-0.3	-0.0	1.0	0.6	0.4	0.6	-0.9	-0.2	-0.5
Chest pain or discomfort	0.3	0.4	1.7	1.1	-1.3	0.1	0.7	-0.6	0.3	0.2	-0.0	1.2	0.2	-0.4	-0.1
Illness, injury, bereavement, stress in last 2 years	0.3	0.3	1.6	0.0	0.3	0.8	0.2	-0.6	-1.3	-0.8	-0.9	0.2	-0.1	-0.6	-0.0
Average weekly red wine intake	0.3	0.4	1.8	-0.4	-0.7	-0.3	0.4	-0.1	1.4	0.5	0.9	0.0	0.3	0.2	0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	2.5	-1.1	1.6	0.2	0.6	-0.7	-0.2	-0.3	-0.3	-0.6	-0.1	0.2	-0.2
Smoking status: Current	0.3	0.5	3.5	-1.9	0.6	-0.2	0.5	-0.6	0.0	-0.7	-0.7	-0.3	0.9	0.1	-0.6
Average weekly champagne plus white wine intake	0.3	0.5	3.5	0.2	-0.6	-0.8	-0.5	0.3	0.9	0.1	0.1	-0.3	-1.9	0.1	-0.1
Commuting to job workplace: Cycle	0.3	0.4	2.1	-0.5	0.3	-0.6	-0.3	-0.4	0.1	-0.1	0.4	-0.3	1.2	0.5	1.4
Cholesterol lowering medication	0.3	0.4	1.1	0.5	0.8	0.7	-0.3	0.3	-1.1	-0.4	-0.5	-0.6	-1.0	-0.7	-1.0
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	1.1	0.0	0.8	-0.8	0.2	0.4	0.9	0.4	0.5	0.1	0.9	0.1	-1.0
Heart disease (siblings)	0.3	0.4	1.9	0.3	-0.5	0.7	0.0	0.2	-1.4	-0.3	-0.6	-0.9	-0.3	-1.1	0.2
Pack years of smoking	0.3	0.5	3.3	-0.1	-0.2	0.8	-0.0	-0.0	-1.8	-0.8	-1.1	-0.3	-0.3	-0.6	-0.3
Intelligence (Savage-Jansen 2018)	0.2	0.8	2.9	0.9	-0.8	0.4	-0.1	-0.9	-1.5	-0.8	-0.9	0.7	0.5	-0.4	1.7
Hand grip strength (left)	0.2	0.6	2.0	0.5	-1.4	-0.9	0.1	0.6	0.2	0.4	-0.2	-0.7	-0.9	-1.0	-1.4
Medication: Metformin	0.2	0.2	0.8	-0.0	0.3	0.9	-0.2	0.6	0.2	0.6	0.6	0.7	0.1	-0.5	-0.5
Diabetes (mother)	0.2	0.3	0.9	-0.0	0.4	0.1	-0.0	0.5	0.8	0.6	0.8	0.4	1.0	-0.3	0.4
Current tobacco smoking	0.2	0.4	2.5	-1.6	0.2	-0.2	0.5	-0.2	0.2	-0.5	-0.4	-0.6	0.9	0.1	-0.5
Qualifications: CSEs or equivalent	0.2	0.3	0.8	0.7	0.8	0.5	-0.5	0.9	-0.4	-0.0	0.0	-0.5	-0.6	-0.4	-0.7
Hayfever, allergic rhinitis or eczema	0.2	0.4	2.2	-1.0	0.1	-0.2	-0.6	-0.7	-0.9	-0.3	-0.3	-0.8	1.5	-0.4	0.1
Sitting height	0.2	1.2	8.8	3.0	-1.0	-0.9	0.3	1.1	-0.6	-0.0	-0.7	1.1	-0.2	-0.0	-1.0
Allergy	0.2	0.6	2.4	0.6	1.0	-0.0	0.2	0.6	1.0	0.5	0.7	0.5	-0.5	1.6	0.9
Standing height	0.2	1.5	6.6	1.1	0.1	-2.3	0.9	1.7	-0.0	0.3	-0.2	0.1	2.6	1.5	-0.6
Comparative height size at age 10	0.2	1.0	7.9	-0.2	-0.7	-0.6	0.6	0.5	-1.2	-0.5	-1.0	0.1	2.8	0.9	-0.6
High cholesterol (Self-reported)	0.2	0.4	2.5	-0.2	1.6	-0.7	0.7	-0.3	-0.5	-0.7	-0.8	-0.5	-0.2	0.5	-0.2
Supplements: Calcium	0.2	0.3	2.1	1.4	-0.2	-0.1	-0.8	0.2	0.1	0.5	0.4	0.1	0.4	0.1	0.3
Average weekly spirits intake	0.1	0.1	0.7	0.5	0.5	-0.8	-0.5	-0.1	-0.1	0.1	0.1	-0.3	-0.3	-0.2	-0.0
Ever used hormone-replacement therapy (HRT)	0.1	0.2	0.9	-0.9	0.2	0.4	-0.8	-0.6	0.2	-0.1	0.0	-0.0	0.0	0.2	0.3
Wears glasses or contact lenses	0.1	0.2	0.4	0.4	-0.1	-0.3	0.4	-0.4	-0.4	-0.3	-0.1	0.3	-0.5	0.5	0.7
Age started oral contraceptive pill	0.1	0.2	0.6	0.8	0.5	-0.3	0.8	-0.2	0.2	0.2	0.0	0.2	-0.7	0.6	-0.2
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Mean Putamen Volume	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Fasting Glucose	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
HbA1C	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
HDL Cholesterol	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
LDL Cholesterol	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Lupus	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Neuroticism (2016)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Primary Biliary Cirrhosis	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Rheumatoid Arthritis	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Schizophrenia (2014)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Triglycerides	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Ulcerative Colitis	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Blood Eosinophil Count	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Blood Platelet Count	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Blood Red Count	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Blood White Count	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Heel T-Score	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
BMI	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Height	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Waist Hip Ratio (WHR)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Systolic Blood Pressure	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Smoking Status	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Allergy or Eczema	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Cardiovascular Disease	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Hypothyroidism (self reported)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Respiratory disease	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Type 2 Diabetes (T2D) (2018)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Lung FEV1/FVC ratio	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Lung FVC	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Neuroticism	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Chronotype (morning person)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Hair Pigment	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Tanning	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0

Hub : Genes

LRRC16A

Models

Trait associations