Best TWAS P=6.88e-11 · Best GWAS P=9.06e-14 conditioned to 0.0041
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Hypothalamus | AC004453.8 | 0.54 | 0.13 | lasso | 7 | 0.16 | 1.8e-04 | -2.3 | -5.7 | 1.0e-08 | 0.55 | 0.04 | 0.39 | TRUE |
| 2 | GTEx | Cells Transformed fibroblasts | ZMIZ2 | 0.12 | 0.09 | lasso | 4 | 0.06 | 2.3e-05 | -6.5 | -6.5 | 6.9e-11 | 0.68 | 0.04 | 0.95 | TRUE |
| 3 | The Cancer Genome Atlas | Brain Lower Grade Glioma | PPIA | 0.05 | 0.02 | enet | 5 | 0.03 | 7.7e-05 | -7.5 | -6.1 | 1.3e-09 | 0.82 | 0.00 | 0.94 | FALSE |