Hub : Genes

PPIA

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Skin Sun Exposed Lower leg 0.1260 0.0420 0.00016 0.106 NA 0.098 NA 0.107 4.1e-09 NA 1.6e-08 NA 3.9e-09
2 YFS Blood 0.0812 0.0187 0.00000 0.082 0.072 0.075 0.078 0.079 2.0e-25 1.9e-22 2.4e-23 2e-24 1.0e-24
3 TCGA Brain Lower Grade Glioma 0.0461 0.0268 0.00100 0.022 0.032 0.034 NA 0.034 1.3e-03 1.2e-04 7.7e-05 NA 8.3e-05
4 TCGA Prostate Adenocarcinoma 0.1006 0.0527 0.00095 0.004 0.030 0.031 NA 0.011 1.2e-01 4.1e-04 3.0e-04 NA 2.4e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 0.8 1.3 1.9 -1.4 1.2 0.5 -1.3
Bipolar Disorder or Schizophrenia 1.1 2.7 5.0 -1.2 2.2 2.0 0.2
Depressed Affect (Nagel 2018) 0.6 1.2 1.7 -1.2 1.3 0.9 -0.8
Depression (Nagel 2018) 0.0 0.1 0.1 -0.3 -0.1 -0.4 -0.2
Intelligence (Savage-Jansen 2018) 0.5 1.5 2.2 -0.7 -1.3 1.3 -1.5
Neuroticism (Nagel 2018) 0.5 1.2 1.8 -1.4 1.2 0.5 -1.2
Schizophrenia (2018) 1.2 2.6 4.9 -0.4 1.9 2.2 1.3
Schizophrenia vs Biploar Disorder 0.6 0.8 1.7 -0.4 1.3 1.0 0.5
Worry (Nagel 2018) 0.2 0.4 0.6 -0.8 0.6 0.4 -0.5
Alzheimer’s Disease (in mother) 1.5 1.7 3.0 0.9 -1.7 -1.7 -0.3
Alzheimer’s Disease (in father) 2.0 2.2 4.0 -1.1 2.0 1.9 -0.0
Alzheimer’s Disease (including proxy) 0.0 0.1 0.1 0.1 0.2 -0.2 -0.3
Crohns Disease (2017) 1.0 2.3 6.7 -0.7 1.3 2.6 0.5
Irritable Bowel Disease (IBD) 1.0 2.3 7.6 -0.9 0.9 2.8 0.3
Ulcerative Colitis (UC) 0.3 0.6 1.4 -0.9 0.0 1.2 -0.6
Major Depression (MDD) 1.0 1.2 1.7 -0.9 1.2 1.0 -1.3
Reaction Time 3.0 5.6 10.5 0.9 2.4 3.2 2.4
Verbal and Numeric Reasoning (VNR) 0.7 1.7 4.0 -1.1 -0.5 1.2 -2.0
Breast Cancer 1.0 2.5 3.5 0.4 1.7 1.9 1.8
Ovarian Cancer 1.0 1.4 3.0 -0.5 1.7 1.3 0.8
Prostate Cancer 1.2 1.7 3.0 -1.0 1.7 1.7 0.3
Age at First Birth 2.6 3.8 6.8 -2.6 1.9 1.5 -1.7
Bipolar Disorder (2011) 0.3 0.3 0.7 -0.5 0.8 0.0 0.0
Body Mass Index (BMI) (2010) 2.1 2.9 5.5 1.3 -2.3 -1.9 0.9
Coronary Artery Disease (CAD) 0.3 0.3 0.8 0.4 -0.9 0.3 0.6
Crohns Disease (2012) 1.0 1.6 4.1 0.2 1.1 2.0 1.1
Mean Putamen Volume 0.8 0.9 1.7 -1.1 0.6 -0.5 -1.3
Fasting Glucose 1.6 1.9 6.3 -0.2 -1.0 -2.5 -0.6
HbA1C 0.7 0.8 1.5 0.8 -0.9 -0.2 1.2
HDL Cholesterol 2.5 4.1 7.9 -1.6 2.8 2.4 -0.5
LDL Cholesterol 0.2 0.4 1.4 -0.0 -1.2 -0.4 -0.0
Lupus 0.8 1.3 2.4 1.5 -1.3 -0.6 0.9
Neuroticism (2016) 1.6 2.3 4.0 -2.0 1.3 0.5 -1.8
Primary Biliary Cirrhosis 3.1 4.4 9.4 1.9 -1.4 1.7 3.1
Rheumatoid Arthritis 1.7 2.3 4.2 1.9 -1.0 -0.5 2.1
Schizophrenia (2014) 1.9 4.1 7.9 -1.4 2.8 2.5 0.6
Triglycerides 0.3 0.5 1.3 -0.1 -0.8 -1.1 0.0
Type 2 Diabetes (T2D) (2012) 1.3 1.5 2.9 1.7 -0.5 0.2 1.7
Ulcerative Colitis 0.3 0.5 1.6 -0.4 -0.0 1.3 0.4
Blood Eosinophil Count 1.4 10.5 20.7 2.2 -4.5 -3.6 -1.8
Blood Platelet Count 3.0 34.6 102.0 4.1 -4.2 -10.1 -1.5
Blood Red Count 2.8 27.0 82.8 3.9 -3.1 -9.1 -0.5
Blood White Count 1.7 12.8 29.7 3.1 -3.4 -5.5 0.6
Heel T-Score 0.4 3.0 5.5 2.3 -1.5 -0.0 2.1
BMI 2.5 14.4 47.1 1.3 -2.6 -6.9 -1.3
Height 0.2 4.4 13.5 0.2 -3.7 -1.5 -1.4
Waist Hip Ratio (WHR) 0.3 1.4 1.5 -1.2 1.1 1.2 -1.2
Systolic Blood Pressure 0.5 2.6 5.2 1.6 -1.4 -0.5 2.3
Smoking Status 1.5 3.5 8.0 1.1 -2.1 -2.8 -0.5
Allergy or Eczema 0.8 2.2 5.0 1.0 -0.3 2.2 1.6
Cardiovascular Disease 0.6 2.1 3.2 1.8 -1.5 -1.0 1.4
Hypothyroidism (self reported) 1.2 2.7 3.5 -0.8 -1.8 -1.9 -1.9
Respiratory disease 0.2 0.5 0.9 0.4 -0.8 0.3 0.9
Type 2 Diabetes (T2D) (2018) 0.6 1.2 2.8 -0.4 1.0 -1.7 -0.8
Lung FEV1/FVC ratio 0.7 3.5 9.9 -0.0 -1.1 -3.1 -1.7
Lung FVC 0.4 2.3 6.8 0.4 1.1 1.0 2.6
Neuroticism 0.4 0.9 1.4 -0.8 0.9 0.7 -1.2
Chronotype (morning person) 0.4 0.8 1.7 -1.0 1.3 -0.1 -0.7
Hair Pigment 0.1 3.9 6.4 1.9 -2.5 -2.3 0.2
Tanning 0.2 2.9 5.8 -0.8 2.4 2.3 0.1
Hand grip strength (left) 0.1 0.3 1.2 0.3 0.3 1.1 0.1
Number of treatments/medications taken 0.0 0.1 0.2 -0.1 -0.0 -0.4 0.1
Average weekly spirits intake 1.3 1.6 4.5 0.1 -0.9 -2.1 -1.1
Sensitivity / hurt feelings 0.1 0.1 0.3 -0.1 0.5 -0.3 -0.1
Frequency of depressed mood in last 2 weeks 0.4 0.5 1.4 -1.2 0.2 -0.3 -0.7
Hearing difficulty/problems: Yes 1.4 2.2 4.6 -1.4 -0.1 -1.5 -2.1
Relative age of first facial hair 0.2 0.4 1.1 0.3 -1.1 0.0 0.5
Other serious medical condition/disability diagnosed by doctor 0.4 0.5 0.8 0.6 -0.9 -0.4 0.9
Ever used hormone-replacement therapy (HRT) 2.9 3.6 6.3 -2.5 1.9 1.2 -1.7
Ever had hysterectomy (womb removed) 0.7 0.8 1.6 0.5 -1.3 -1.2 -0.3
Systolic blood pressure, automated reading 0.8 2.3 2.8 1.5 -1.6 -1.7 1.4
Eye problems/disorders: Diabetes related eye disease 4.5 4.9 7.6 -2.5 2.8 1.6 -1.8
Angina 0.1 0.2 0.4 -0.2 0.6 -0.5 0.1
Medication for hormone replacement therapy 3.0 3.3 5.8 -1.4 2.3 2.4 0.1
Vitamin and mineral supplements 0.5 0.7 1.5 1.2 -0.6 -0.0 1.0
Supplements: Zinc 0.5 0.5 0.8 -0.9 0.9 0.3 -0.6
Medication: Co-codamol 0.2 0.2 0.5 0.1 0.7 -0.6 -0.3
Medication: Metformin 0.9 1.2 1.7 -1.0 1.0 -1.1 -1.3
Diabetes (father) 0.7 0.9 1.6 0.9 -0.4 0.9 1.3
Diabetes (mother) 2.7 3.5 5.4 -2.1 2.0 -0.1 -2.3
Severe depression (siblings) 0.5 0.6 1.4 -0.7 1.2 0.5 -0.6
Pack years adult smoking proportion 1.6 2.5 4.9 1.3 -1.7 -2.2 0.6
Impedance of leg (right) 1.0 4.8 14.1 -0.9 2.0 3.7 0.6
Leg fat-free mass (left) 2.8 14.9 39.4 1.5 -3.9 -6.3 -1.7
Trunk fat percentage 2.6 10.6 32.3 1.6 -2.7 -5.7 -0.4
Hand grip strength (right) 0.0 0.1 0.4 0.1 0.0 0.1 -0.6
Townsend deprivation index at recruitment 0.1 0.1 0.2 0.2 0.3 -0.5 0.2
Current tobacco smoking 1.6 2.6 7.7 0.8 -1.4 -2.8 -0.2
Average weekly fortified wine intake 1.4 1.6 3.6 0.4 -1.9 -1.5 -0.5
Maternal smoking around birth 1.3 1.8 2.6 -1.5 0.5 -1.5 -1.6
Fed-up feelings 0.2 0.3 0.8 -0.4 0.5 -0.9 0.1
Frequency of unenthusiasm / disinterest in last 2 weeks 0.9 1.2 4.8 -0.1 -0.3 -2.2 -0.3
Relative age voice broke 0.5 0.7 1.5 -0.5 -1.2 -0.8 -0.8
Taking other prescription medications 0.6 0.9 1.5 -1.2 1.0 -0.2 -1.0
Age when periods started (menarche) 0.4 1.0 2.0 -0.1 -1.4 -1.2 -0.7
Bilateral oophorectomy (both ovaries removed) 0.1 0.2 0.4 -0.1 -0.2 0.7 0.4
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.7 2.1 0.3 1.4 0.8 0.4
Tinnitus: Yes, but not now, but have in the past 4.2 4.5 8.0 1.8 -2.1 -2.8 1.5
Qualifications: CSEs or equivalent 1.2 1.6 6.1 0.2 -0.1 -2.5 -0.6
Serious illness, injury or assault to yourself 1.4 1.7 3.6 -1.9 1.4 -0.4 -1.1
High blood pressure 0.7 2.0 3.6 1.9 -1.3 -0.6 1.4
Hayfever, allergic rhinitis or eczema 1.1 2.3 4.4 1.4 -0.7 2.1 1.6
Multivitamins +/- minerals 3.0 3.8 7.5 -2.7 1.1 -0.0 -2.5
Stomach or abdominal pain in last month 0.8 1.0 2.2 1.5 -0.8 -0.0 1.0
Supplements: Glucosamine 2.3 3.0 4.1 -2.0 1.8 2.0 -1.0
Diverticular disease/diverticulitis (self-reported) 1.9 2.2 5.0 1.5 -1.0 0.9 2.2
Medication: Atenolol 0.9 1.1 3.0 0.7 -0.2 0.9 1.7
Medication: Levothyroxine sodium 0.7 1.1 1.9 -0.6 -0.7 -1.4 -1.3
Sitting height 0.4 2.7 5.9 1.9 -2.4 -0.2 1.1
Chronic bronchitis/emphysema (father) 2.6 3.1 4.1 2.0 -1.9 -1.4 1.6
High blood pressure (mother) 0.2 0.2 0.5 0.6 -0.3 -0.2 0.7
Body mass index (BMI) 3.5 15.0 46.9 2.2 -2.9 -6.8 -0.2
Impedance of leg (left) 1.4 6.8 18.6 -1.4 2.5 4.3 0.6
Leg predicted mass (left) 2.9 15.2 39.9 1.6 -4.0 -6.3 -1.6
Trunk fat mass 3.4 14.5 42.4 1.9 -3.4 -6.5 -0.8
Waist circumference 2.4 8.9 26.8 1.4 -2.5 -5.2 -0.7
Number of incorrect matches in round 3.7 6.1 10.0 -2.5 3.2 2.8 -0.7
Past tobacco smoking 0.4 0.8 2.3 0.9 0.1 0.1 1.5
Alcohol usually taken with meals 3.6 5.8 9.9 -3.1 2.4 1.8 -2.0
Nervous feelings 0.7 1.2 2.4 -1.5 0.1 0.6 -1.5
Frequency of tenseness / restlessness in last 2 weeks 0.1 0.2 0.3 0.3 -0.5 -0.5 0.3
Hearing difficulty/problems with background noise 1.1 1.7 3.0 -1.7 1.0 1.1 -1.2
Hair/balding pattern: Pattern 2 0.1 0.1 0.3 -0.1 0.5 0.1 -0.5
Had menopause 1.2 1.5 2.5 -1.3 0.9 1.6 -0.9
Had other major operations 0.9 1.0 1.9 -1.2 0.9 1.4 -0.4
Forced vital capacity (FVC) 0.1 0.3 0.8 0.2 -0.6 -0.9 0.1
Heel bone mineral density (BMD) T-score, automated (right) 0.9 2.0 4.3 -0.6 2.1 1.8 0.0
Ever unenthusiastic/disinterested for a whole week 1.2 1.5 2.6 -1.1 0.0 -1.5 -1.6
Qualifications: None of the above 2.4 5.2 11.4 1.7 -2.1 -3.4 1.4
Financial difficulties in last 2 years 1.5 2.1 5.2 -1.3 2.3 1.2 -0.1
Mouth/teeth dental problems 0.6 0.9 2.7 0.9 -1.6 0.3 0.2
Heart attack 0.7 0.9 1.8 1.1 -0.4 -0.6 1.3
Allergy 0.9 2.2 3.6 -1.5 0.7 -1.6 -1.9
Pain all over the body in last month 0.8 0.8 1.3 1.0 -1.0 -1.1 0.4
Diabetes (self-reported) 0.4 0.6 1.7 -0.3 0.8 -1.3 -0.3
Hayfever/allergic rhinitis (self-reported) 0.3 0.4 1.2 -0.6 -0.2 0.5 -1.1
Medication: Ramipril 1.0 1.3 1.9 1.1 -1.4 -1.3 0.8
Medication: Simvastatin 2.7 3.9 6.2 1.8 -2.0 -2.5 1.4
Fluid intelligence score 1.1 2.4 5.4 -1.4 0.3 1.4 -2.3
Illnesses of siblings 2.3 3.2 4.4 -1.6 1.7 2.1 -1.7
Neuroticism score 0.5 0.9 1.5 -1.2 0.3 -0.8 -1.2
Weight 3.3 16.0 45.0 2.0 -3.8 -6.7 -0.9
Impedance of arm (right) 1.1 4.9 11.4 -2.1 1.7 3.4 -1.0
Arm fat percentage (right) 3.0 11.7 37.7 1.4 -2.5 -6.1 -0.7
Trunk fat-free mass 1.7 9.6 22.0 1.5 -3.6 -4.7 -1.2
Hip circumference 2.6 11.1 29.8 1.8 -3.3 -5.5 -0.4
Time employed in main current job 2.7 3.1 4.9 2.2 -2.2 -1.6 0.5
Alcohol intake versus 10 years previously 0.4 0.7 2.4 -0.3 -0.3 -1.6 0.0
Father’s age at death 0.8 1.0 1.7 -1.3 1.2 1.0 -0.1
Worrier / anxious feelings 0.2 0.3 1.1 -0.1 -0.1 -1.1 -0.4
Frequency of tiredness / lethargy in last 2 weeks 0.1 0.1 0.3 -0.6 0.0 -0.2 -0.4
Falls in the last year 2.5 3.4 7.0 2.1 -1.2 -0.8 2.6
Hair/balding pattern: Pattern 3 0.3 0.4 1.0 0.7 0.0 1.0 0.4
Number of live births 0.3 0.4 1.0 -0.1 0.7 1.0 0.5
Forced expiratory volume in 1-second (FEV1) 0.3 0.9 2.7 0.5 -0.8 -1.6 -0.0
Pulse rate 1.9 3.2 5.9 -0.2 1.9 2.4 1.8
Happiness 1.4 1.7 2.6 -1.5 0.8 1.1 -1.6
Noisy workplace 2.3 2.8 7.9 -1.0 1.0 -2.8 -1.1
Qualifications: A levels/AS levels or equivalent 1.5 3.3 7.5 -1.6 1.5 2.7 -1.0
Serious illness, injury or assault of a close relative in last 2 years 0.9 1.1 1.6 -1.1 0.3 -1.1 -1.3
Mouth/teeth dental problems: Dentures 0.5 0.9 1.3 1.1 -0.8 -0.6 1.1
Asthma 0.7 1.3 3.2 0.6 -1.8 -1.4 0.1
Medication: Ibuprofen (e.g. Nurofen) 0.1 0.1 0.3 0.2 0.6 0.2 0.3
Medication: Cholesterol lowering 0.8 1.2 1.9 1.3 -0.7 -0.9 1.4
Depression (self-reported) 2.3 2.8 6.1 -1.5 0.3 -1.7 -2.5
Medication: Lansoprazole 0.3 0.3 0.6 0.4 0.5 0.6 0.8
Prospective memory result 0.4 0.5 1.8 0.3 0.0 -0.4 1.4
Lung cancer (father) 0.2 0.2 0.3 0.6 -0.4 -0.5 0.4
Illnesses of mother 0.1 0.1 0.4 0.1 0.0 0.6 0.3
Forced expiratory volume in 1-second (FEV1), Best measure 0.0 0.1 0.3 0.2 -0.2 -0.6 0.0
Pulse wave Arterial Stiffness index 1.9 2.2 3.3 -1.8 1.2 0.9 -1.8
Impedance of arm (left) 0.8 3.7 10.8 -1.6 1.2 3.3 -0.3
Arm fat mass (right) 3.9 16.0 47.9 1.9 -3.5 -6.9 -0.8
Trunk predicted mass 1.7 9.6 22.2 1.5 -3.5 -4.7 -1.3
Standing height 0.2 2.3 5.5 -0.2 -2.4 -0.5 -1.8
Length of working week for main job 2.4 2.7 6.6 1.3 -1.6 -2.6 -0.1
Exposure to tobacco smoke at home 0.5 0.5 1.2 -0.2 1.1 0.9 0.5
Breastfed as a baby 0.7 0.9 1.7 -1.1 0.8 -0.3 -1.3
Tense / ‘highly strung’ 0.7 1.2 2.5 -1.6 0.6 -0.4 -1.4
Seen doctor (GP) for nerves, anxiety, tension or depression 2.0 3.0 6.3 -2.5 1.7 0.5 -1.7
Hair/balding pattern: Pattern 4 0.4 1.1 2.1 -0.9 -0.1 -1.2 -1.4
Birth weight of first child 0.9 1.6 3.9 -0.7 -0.9 -1.1 -2.0
Peak expiratory flow (PEF) 0.9 2.1 5.4 1.0 -1.3 -2.3 -0.5
Pulse wave reflection index 3.2 4.0 9.1 -2.3 1.3 -0.0 -3.0
Ever highly irritable/argumentative for 2 days 3.7 4.4 13.2 -0.1 -1.3 -3.6 -1.6
Loud music exposure frequency 0.6 0.6 1.5 0.9 -0.4 -0.1 1.2
Qualifications: O levels/GCSEs or equivalent 0.7 1.1 3.8 -0.1 0.6 1.9 -0.2
Mouth/teeth dental problems: Bleeding gums 0.8 1.1 2.3 -0.6 1.5 1.3 0.4
Blood clot in the leg (DVT) 0.6 0.8 1.5 -0.4 0.1 -1.2 -1.2
Medication: Paracetamol 0.1 0.1 0.3 -0.3 0.5 -0.3 0.1
Headache pain in last month 0.4 0.6 0.9 -0.4 1.0 0.8 0.8
Medication for cholesterol, blood pressure or diabetes 1.8 3.0 4.9 -2.2 1.7 1.3 -1.6
Glaucoma (self-reported) 4.2 5.0 7.6 -2.4 2.4 0.7 -2.8
Gout (self-reported) 0.1 0.2 0.3 0.5 -0.5 -0.6 0.1
Hypothyroidism/myxoedema (self-reported) 1.0 1.9 3.0 -0.3 -1.7 -1.7 -1.3
Medication: Amlodipine 0.2 0.2 0.5 -0.3 0.7 0.1 -0.5
Medication: Ventolin 100micrograms inhaler 0.4 0.6 0.8 -0.8 0.7 0.9 -0.6
Birth weight 0.7 1.6 3.2 -1.1 1.8 1.2 -0.5
Chronic bronchitis/emphysema (mother) 0.3 0.4 0.7 -0.5 -0.0 -0.8 -0.7
High blood pressure (siblings) 0.2 0.3 0.6 0.4 -0.4 -0.5 0.7
Forced vital capacity (FVC), Best measure 0.0 0.2 0.4 0.0 -0.2 0.7 0.4
Body fat percentage 2.8 11.0 35.3 1.6 -2.4 -5.9 -0.4
Leg fat percentage (right) 3.2 11.4 37.7 1.8 -2.2 -6.1 -0.2
Arm fat-free mass (right) 2.6 13.4 34.6 1.9 -3.8 -5.9 -1.1
Exposure to tobacco smoke outside home 0.9 1.2 2.4 1.6 -0.5 -0.8 1.1
Comparative body size at age 10 1.5 4.1 10.2 1.4 -2.1 -3.2 0.2
Number of full brothers 0.4 0.6 0.9 -0.7 1.0 0.3 -0.8
Worry too long after embarrassment 1.6 2.7 3.9 -1.9 2.0 -0.2 -1.8
Seen a psychiatrist for nerves, anxiety, tension or depression 0.4 0.5 1.0 -1.0 0.6 0.6 -0.8
Wheeze or whistling in the chest in last year 0.4 0.7 1.7 -0.6 0.4 -1.3 -0.9
Number of children fathered 1.0 1.1 1.9 -1.0 1.2 -0.3 -1.4
Reason for reducing amount of alcohol drunk: Health precaution 0.6 0.7 1.8 0.5 -0.6 -1.4 -0.6
Age at first live birth 0.2 0.4 1.0 -0.3 -0.7 0.4 -1.0
Pulse wave peak to peak time 1.8 2.2 3.2 1.8 -1.3 -1.0 1.6
Health satisfaction 0.5 0.6 1.8 -0.6 0.5 1.3 0.2
Shortness of breath walking on level ground 0.3 0.3 0.6 -0.4 0.8 0.7 0.3
Qualifications: College or University degree 1.1 3.4 11.8 -1.3 0.4 3.4 -0.2
Eye problems/disorders: None of the above 0.8 0.9 2.4 0.6 -1.6 -0.6 0.8
Mouth/teeth dental problems: Loose teeth 0.9 1.1 3.0 -0.8 1.7 0.8 -0.0
Emphysema/chronic bronchitis 0.1 0.1 0.1 0.3 0.2 0.3 0.1
Medication for pain relief, constipation, heartburn 0.3 0.5 0.9 0.5 -1.0 0.9 0.4
Neck or shoulder pain in last month 0.9 1.3 2.7 0.5 0.4 1.6 1.5
Medication: Blood pressure 0.7 1.3 2.0 1.4 -1.0 -0.9 1.2
Angina (self-reported) 0.1 0.1 0.3 -0.1 0.6 -0.4 0.3
Migraine (self-reported) 1.3 1.6 3.6 -0.4 1.4 1.9 0.8
Medication: Ibuprofen 0.2 0.2 0.4 0.6 0.2 0.2 0.7
Medication: Allopurinol 0.4 0.6 1.1 0.7 -0.7 -1.1 0.6
Medication: Omeprazole 0.0 0.0 0.1 0.2 -0.4 0.1 0.1
Medication: Seretide 50 evohaler 0.7 0.8 1.5 -1.1 0.1 -0.6 -1.2
Mean time to correctly identify matches 3.5 6.6 10.3 0.9 2.4 3.2 3.1
Heart disease (mother) 0.3 0.3 0.5 0.3 0.7 0.7 0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.6 0.7 1.5 0.6 0.2 1.0 1.2
Whole body fat mass 3.7 15.5 46.5 1.9 -3.4 -6.8 -0.7
Leg fat mass (right) 3.8 14.7 46.5 1.9 -2.9 -6.8 -0.6
Arm predicted mass (right) 2.6 13.4 33.8 2.0 -3.9 -5.8 -0.9
Pulse rate, automated reading 0.7 2.2 4.0 -0.5 1.3 1.7 2.0
Alcohol intake frequency. 4.5 10.5 24.4 2.5 -3.4 -4.9 0.6
Comparative height size at age 10 0.4 2.1 7.0 1.1 -2.6 -0.4 0.3
Number of full sisters 0.3 0.3 1.2 0.4 -0.1 -1.1 0.1
Suffer from ‘nerves’ 1.3 2.1 4.2 -1.5 1.2 2.0 -0.5
Overall health rating 0.5 1.1 2.2 -0.9 0.1 -1.5 -1.2
Chest pain or discomfort 0.5 0.7 2.0 0.9 -0.1 -0.1 1.4
Had major operations 0.3 0.3 0.6 -0.1 -0.4 -0.8 -0.7
Age at last live birth 0.9 1.4 3.1 0.3 -1.8 -0.9 -1.2
Family relationship satisfaction 3.3 4.0 6.7 -2.6 1.6 1.1 -2.4
Leg pain on walking 0.4 0.6 0.7 0.6 -0.8 -0.8 0.8
Qualifications: NVQ or HND or HNC or equivalent 1.0 1.2 3.6 1.1 -0.1 -1.9 0.1
Commuting to job workplace: Car/motor vehicle 1.8 2.1 5.4 1.6 -0.5 0.3 2.3
Illness, injury, bereavement, stress in last 2 years 1.2 1.5 2.7 1.0 -1.0 1.6 1.1
Medication: Aspirin 1.0 1.3 2.7 -0.9 0.9 -1.7 -1.0
Supplements: Vitamin C 0.5 0.6 1.6 1.2 0.0 -0.2 0.9
Knee pain experienced in last month 0.3 0.4 0.9 0.2 -0.7 -0.6 0.9
Hypertension (Self-reported) 0.6 1.7 3.1 1.8 -1.2 -0.6 1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.2 0.2 0.3 -0.6 0.5 0.3 -0.3
Illnesses of father: Heart disease 1.1 1.5 2.6 -1.2 1.6 1.4 -0.2
Illnesses of siblings: Diabetes 0.2 0.2 0.4 -0.4 0.4 -0.6 -0.4
Smoking status: Previous 0.4 0.6 2.0 -0.6 -0.2 0.1 -1.4
Forced expiratory volume in 1-second (FEV1), predicted 0.1 0.2 0.4 -0.1 -0.7 -0.4 -0.6
Whole body fat-free mass 2.3 13.2 32.4 1.7 -4.0 -5.7 -1.4
Leg fat-free mass (right) 2.5 13.3 34.7 1.4 -3.8 -5.9 -1.6
Arm fat percentage (left) 3.2 12.6 40.3 1.6 -2.7 -6.3 -0.5
Average weekly red wine intake 0.3 0.4 0.5 0.6 -0.6 0.5 0.7
Handedness (chirality/laterality): Left-handed 0.8 1.0 2.4 -0.2 0.4 1.6 1.1
Mood swings 0.6 1.2 2.7 -1.1 1.6 0.8 0.2
Loneliness, isolation 1.3 1.8 3.5 -1.9 1.5 0.5 -1.1
Long-standing illness, disability or infirmity 2.2 3.3 4.1 2.0 -1.8 -1.8 1.7
Ever had bowel cancer screening 0.1 0.1 0.2 0.1 -0.1 -0.4 0.3
Diabetes diagnosed by doctor 1.0 1.6 6.1 0.3 -0.0 -2.5 -0.5
Ever had stillbirth, spontaneous miscarriage or termination 0.6 0.6 1.4 -1.2 0.5 0.7 -0.5
Friendships satisfaction 4.8 5.9 7.4 -2.6 1.9 2.7 -2.5
Qualifications: nursing, teaching 0.6 1.0 2.0 0.9 -1.4 -0.0 1.0
Commuting to job workplace: Walk 0.9 1.0 2.4 -1.1 -0.0 -0.6 -1.5
Eye problems/disorders: Cataract 0.2 0.2 0.5 0.7 -0.2 -0.4 0.2
Mouth/teeth dental problems: Mouth ulcers 0.1 0.2 0.5 0.2 0.2 -0.4 0.7
Medication for cholesterol 0.1 0.2 0.5 -0.2 -0.1 -0.0 -0.7
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.4 0.5 1.6 -0.2 0.0 1.3 -0.6
Back pain experienced in last month 0.3 0.4 0.8 0.9 -0.4 -0.3 0.7
Mineral and other dietary supplements 0.6 0.8 1.7 1.3 -0.7 -0.1 1.1
Breast cancer (self-reported) 0.1 0.1 0.2 0.4 0.4 0.1 -0.4
Asthma (self-reported) 0.3 0.7 1.8 0.3 -1.3 -0.9 0.2
Osteoporosis (self-reported) 0.5 0.6 1.0 0.8 -1.0 0.7 0.5
Osteoarthritis (self-reported) 0.3 0.4 1.0 0.3 -0.2 -1.0 0.6
Medication: Aspirin 0.8 1.1 3.6 -0.4 0.3 -1.9 -0.5
Medication: Gliclazide 2.8 3.2 7.5 1.2 -1.9 -2.7 0.2
Illnesses of father: None of the above (group 1) 0.0 0.0 0.1 -0.1 -0.0 0.2 -0.3
Smoking status: Current 1.2 1.9 5.7 0.6 -1.1 -2.4 -0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.5 1.2 0.9 -0.0 0.2 1.1
Whole body water mass 2.1 12.2 30.0 1.6 -3.8 -5.5 -1.5
Leg predicted mass (right) 2.4 13.0 33.9 1.3 -3.7 -5.8 -1.6
Arm fat mass (left) 3.8 15.5 46.5 1.9 -3.3 -6.8 -0.7
Number of self-reported non-cancer illnesses 0.1 0.2 0.4 0.2 -0.6 -0.7 0.2
Average weekly champagne plus white wine intake 4.0 5.5 8.2 -2.4 2.9 2.8 -0.5
Miserableness 0.7 1.2 2.1 -1.4 1.2 0.7 -1.0
Guilty feelings 3.1 4.7 8.8 -3.0 2.1 0.3 -2.3
Wears glasses or contact lenses 0.9 1.1 2.3 -1.5 0.8 0.1 -1.1
Ever taken oral contraceptive pill 3.7 4.1 7.1 -1.9 2.1 2.7 -1.1
Hearing aid user 1.0 1.2 2.6 0.8 -1.1 -1.6 -0.6
Mother’s age at death 0.1 0.1 0.2 0.3 -0.4 -0.3 0.2
Financial situation satisfaction 1.8 2.2 4.2 -1.2 1.7 2.0 -0.5
Tinnitus: Yes, now most or all of the time 0.1 0.2 0.3 -0.3 0.1 -0.5 -0.5
Commuting to job workplace: Public transport 0.7 0.8 2.8 0.5 0.0 1.7 0.3
Eye problems/disorders: Glaucoma 2.1 2.5 5.2 -1.7 1.4 -0.2 -2.3
Medication: Blood pressure 0.4 0.8 1.5 1.2 -0.5 -0.3 1.2
Pain type(s) experienced in last month: Hip pain 0.4 0.5 0.7 -0.1 0.9 0.9 0.8
Supplements: Fish oil (including cod liver oil) 0.9 1.1 1.8 -1.4 1.3 0.6 -0.8
High cholesterol (Self-reported) 0.7 1.2 3.4 0.2 -1.2 -1.9 -0.2
Medication: Bendroflumethiazide 1.3 1.9 4.1 2.0 -1.0 -0.1 1.6
Medication: Paracetamol 0.1 0.2 0.6 0.1 0.1 -0.8 0.5
Medication: Lisinopril 0.8 1.0 2.3 0.7 -1.0 -1.5 -0.6
Medication: Atorvastatin 1.7 2.1 3.4 -1.7 1.8 0.8 -1.3
Illnesses of father: High blood pressure 0.3 0.4 0.8 0.0 -0.9 -0.8 -0.5
Alcohol drinker status: Never 2.8 3.4 4.5 2.1 -2.1 -1.7 1.4
Ever smoked 0.6 1.0 2.3 -1.3 0.2 0.1 -1.5
Basal metabolic rate 2.6 14.3 37.2 1.7 -3.9 -6.1 -1.4
Leg fat percentage (left) 3.0 10.9 36.8 1.7 -2.0 -6.1 -0.1
Arm fat-free mass (left) 2.1 10.7 28.5 1.5 -3.3 -5.3 -1.2
Number of operations (self-reported) 0.1 0.1 0.2 -0.3 -0.4 0.4 -0.3
Average weekly beer plus cider intake 0.1 0.2 0.5 -0.2 -0.2 -0.7 -0.2
Irritability 1.6 2.8 5.7 -1.7 0.7 -1.4 -2.4
Risk taking 2.1 3.1 7.2 -1.8 2.7 1.1 -0.9
Ever had prostate specific antigen (PSA) test 0.5 0.6 1.3 -0.6 0.8 1.1 0.4
Fractured/broken bones in last 5 years 2.6 3.4 5.7 -2.1 1.6 -0.7 -2.4
Age started oral contraceptive pill 0.6 0.7 1.8 -0.4 -0.8 -0.6 -1.4
Diastolic blood pressure, automated reading 2.3 7.0 8.5 2.9 -2.8 -2.4 2.6
Ever depressed for a whole week 1.6 2.0 3.8 -1.9 0.7 -0.6 -1.8
Unable to work because of sickness or disability 0.1 0.1 0.2 -0.4 0.3 -0.5 -0.2
Commuting to job workplace: Cycle 1.5 1.8 3.0 -1.6 1.1 0.2 -1.7
Myopia 0.2 0.3 0.7 -0.3 0.3 0.6 0.8
Vascular/heart problems diagnosed by doctor 0.6 1.6 2.4 -1.6 1.4 0.7 -1.1
Cholesterol lowering medication 0.8 1.1 3.5 0.3 -1.0 -1.9 -0.1
Medication: Omeprazole (e.g. Zanprol) 0.1 0.1 0.2 0.3 -0.4 -0.2 -0.0
Pain experienced in last month 0.5 0.9 2.0 -0.7 -0.7 -0.8 -1.4
Supplements: Calcium 0.6 0.7 1.3 -1.0 -0.1 -0.6 -1.1
Basal cell carcinoma (self-reported) 1.8 2.1 4.0 -2.0 1.5 0.2 -1.5
Heart attack/myocardial infarction (self-reported) 0.6 0.8 1.4 1.0 -0.4 -0.7 1.2
Deep venous thrombosis (DVT) (self-reported) 0.5 0.7 1.7 -0.2 -0.1 -1.3 -1.0
Heart disease (siblings) 0.8 1.0 3.5 0.4 -0.3 -1.9 -0.4
Alcohol drinker status: Previous 1.3 1.5 3.1 0.9 -1.4 -1.8 0.2
Pack years of smoking 1.3 2.0 3.8 1.1 -1.5 -2.0 0.7
Impedance of whole body 1.1 5.6 16.1 -1.5 1.9 4.0 0.1
Leg fat mass (left) 3.7 14.6 46.5 1.9 -2.9 -6.8 -0.6
Arm predicted mass (left) 2.4 12.1 31.9 1.7 -3.5 -5.7 -1.3