Hub : Genes

PPIA

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Skin Sun Exposed Lower leg	0.1260	0.0420	0.00016	0.106	NA	0.098	NA	0.107	4.1e-09	NA	1.6e-08	NA	3.9e-09
2	YFS	Blood	0.0812	0.0187	0.00000	0.082	0.072	0.075	0.078	0.079	2.0e-25	1.9e-22	2.4e-23	2e-24	1.0e-24
3	TCGA	Brain Lower Grade Glioma	0.0461	0.0268	0.00100	0.022	0.032	0.034	NA	0.034	1.3e-03	1.2e-04	7.7e-05	NA	8.3e-05
4	TCGA	Prostate Adenocarcinoma	0.1006	0.0527	0.00095	0.004	0.030	0.031	NA	0.011	1.2e-01	4.1e-04	3.0e-04	NA	2.4e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.8	1.3	1.9	-1.4	1.2	0.5	-1.3
Bipolar Disorder or Schizophrenia	1.1	2.7	5.0	-1.2	2.2	2.0	0.2
Depressed Affect (Nagel 2018)	0.6	1.2	1.7	-1.2	1.3	0.9	-0.8
Depression (Nagel 2018)	0.0	0.1	0.1	-0.3	-0.1	-0.4	-0.2
Intelligence (Savage-Jansen 2018)	0.5	1.5	2.2	-0.7	-1.3	1.3	-1.5
Neuroticism (Nagel 2018)	0.5	1.2	1.8	-1.4	1.2	0.5	-1.2
Schizophrenia (2018)	1.2	2.6	4.9	-0.4	1.9	2.2	1.3
Schizophrenia vs Biploar Disorder	0.6	0.8	1.7	-0.4	1.3	1.0	0.5
Worry (Nagel 2018)	0.2	0.4	0.6	-0.8	0.6	0.4	-0.5
Alzheimer’s Disease (in mother)	1.5	1.7	3.0	0.9	-1.7	-1.7	-0.3
Alzheimer’s Disease (in father)	2.0	2.2	4.0	-1.1	2.0	1.9	-0.0
Alzheimer’s Disease (including proxy)	0.0	0.1	0.1	0.1	0.2	-0.2	-0.3
Crohns Disease (2017)	1.0	2.3	6.7	-0.7	1.3	2.6	0.5
Irritable Bowel Disease (IBD)	1.0	2.3	7.6	-0.9	0.9	2.8	0.3
Ulcerative Colitis (UC)	0.3	0.6	1.4	-0.9	0.0	1.2	-0.6
Major Depression (MDD)	1.0	1.2	1.7	-0.9	1.2	1.0	-1.3
Reaction Time	3.0	5.6	10.5	0.9	2.4	3.2	2.4
Verbal and Numeric Reasoning (VNR)	0.7	1.7	4.0	-1.1	-0.5	1.2	-2.0
Breast Cancer	1.0	2.5	3.5	0.4	1.7	1.9	1.8
Ovarian Cancer	1.0	1.4	3.0	-0.5	1.7	1.3	0.8
Prostate Cancer	1.2	1.7	3.0	-1.0	1.7	1.7	0.3
Age at First Birth	2.6	3.8	6.8	-2.6	1.9	1.5	-1.7
Bipolar Disorder (2011)	0.3	0.3	0.7	-0.5	0.8	0.0	0.0
Body Mass Index (BMI) (2010)	2.1	2.9	5.5	1.3	-2.3	-1.9	0.9
Coronary Artery Disease (CAD)	0.3	0.3	0.8	0.4	-0.9	0.3	0.6
Crohns Disease (2012)	1.0	1.6	4.1	0.2	1.1	2.0	1.1
Mean Putamen Volume	0.8	0.9	1.7	-1.1	0.6	-0.5	-1.3
Fasting Glucose	1.6	1.9	6.3	-0.2	-1.0	-2.5	-0.6
HbA1C	0.7	0.8	1.5	0.8	-0.9	-0.2	1.2
HDL Cholesterol	2.5	4.1	7.9	-1.6	2.8	2.4	-0.5
LDL Cholesterol	0.2	0.4	1.4	-0.0	-1.2	-0.4	-0.0
Lupus	0.8	1.3	2.4	1.5	-1.3	-0.6	0.9
Neuroticism (2016)	1.6	2.3	4.0	-2.0	1.3	0.5	-1.8
Primary Biliary Cirrhosis	3.1	4.4	9.4	1.9	-1.4	1.7	3.1
Rheumatoid Arthritis	1.7	2.3	4.2	1.9	-1.0	-0.5	2.1
Schizophrenia (2014)	1.9	4.1	7.9	-1.4	2.8	2.5	0.6
Triglycerides	0.3	0.5	1.3	-0.1	-0.8	-1.1	0.0
Type 2 Diabetes (T2D) (2012)	1.3	1.5	2.9	1.7	-0.5	0.2	1.7
Ulcerative Colitis	0.3	0.5	1.6	-0.4	-0.0	1.3	0.4
Blood Eosinophil Count	1.4	10.5	20.7	2.2	-4.5	-3.6	-1.8
Blood Platelet Count	3.0	34.6	102.0	4.1	-4.2	-10.1	-1.5
Blood Red Count	2.8	27.0	82.8	3.9	-3.1	-9.1	-0.5
Blood White Count	1.7	12.8	29.7	3.1	-3.4	-5.5	0.6
Heel T-Score	0.4	3.0	5.5	2.3	-1.5	-0.0	2.1
BMI	2.5	14.4	47.1	1.3	-2.6	-6.9	-1.3
Height	0.2	4.4	13.5	0.2	-3.7	-1.5	-1.4
Waist Hip Ratio (WHR)	0.3	1.4	1.5	-1.2	1.1	1.2	-1.2
Systolic Blood Pressure	0.5	2.6	5.2	1.6	-1.4	-0.5	2.3
Smoking Status	1.5	3.5	8.0	1.1	-2.1	-2.8	-0.5
Allergy or Eczema	0.8	2.2	5.0	1.0	-0.3	2.2	1.6
Cardiovascular Disease	0.6	2.1	3.2	1.8	-1.5	-1.0	1.4
Hypothyroidism (self reported)	1.2	2.7	3.5	-0.8	-1.8	-1.9	-1.9
Respiratory disease	0.2	0.5	0.9	0.4	-0.8	0.3	0.9
Type 2 Diabetes (T2D) (2018)	0.6	1.2	2.8	-0.4	1.0	-1.7	-0.8
Lung FEV1/FVC ratio	0.7	3.5	9.9	-0.0	-1.1	-3.1	-1.7
Lung FVC	0.4	2.3	6.8	0.4	1.1	1.0	2.6
Neuroticism	0.4	0.9	1.4	-0.8	0.9	0.7	-1.2
Chronotype (morning person)	0.4	0.8	1.7	-1.0	1.3	-0.1	-0.7
Hair Pigment	0.1	3.9	6.4	1.9	-2.5	-2.3	0.2
Tanning	0.2	2.9	5.8	-0.8	2.4	2.3	0.1
Hand grip strength (left)	0.1	0.3	1.2	0.3	0.3	1.1	0.1
Number of treatments/medications taken	0.0	0.1	0.2	-0.1	-0.0	-0.4	0.1
Average weekly spirits intake	1.3	1.6	4.5	0.1	-0.9	-2.1	-1.1
Sensitivity / hurt feelings	0.1	0.1	0.3	-0.1	0.5	-0.3	-0.1
Frequency of depressed mood in last 2 weeks	0.4	0.5	1.4	-1.2	0.2	-0.3	-0.7
Hearing difficulty/problems: Yes	1.4	2.2	4.6	-1.4	-0.1	-1.5	-2.1
Relative age of first facial hair	0.2	0.4	1.1	0.3	-1.1	0.0	0.5
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	0.8	0.6	-0.9	-0.4	0.9
Ever used hormone-replacement therapy (HRT)	2.9	3.6	6.3	-2.5	1.9	1.2	-1.7
Ever had hysterectomy (womb removed)	0.7	0.8	1.6	0.5	-1.3	-1.2	-0.3
Systolic blood pressure, automated reading	0.8	2.3	2.8	1.5	-1.6	-1.7	1.4
Eye problems/disorders: Diabetes related eye disease	4.5	4.9	7.6	-2.5	2.8	1.6	-1.8
Angina	0.1	0.2	0.4	-0.2	0.6	-0.5	0.1
Medication for hormone replacement therapy	3.0	3.3	5.8	-1.4	2.3	2.4	0.1
Vitamin and mineral supplements	0.5	0.7	1.5	1.2	-0.6	-0.0	1.0
Supplements: Zinc	0.5	0.5	0.8	-0.9	0.9	0.3	-0.6
Medication: Co-codamol	0.2	0.2	0.5	0.1	0.7	-0.6	-0.3
Medication: Metformin	0.9	1.2	1.7	-1.0	1.0	-1.1	-1.3
Diabetes (father)	0.7	0.9	1.6	0.9	-0.4	0.9	1.3
Diabetes (mother)	2.7	3.5	5.4	-2.1	2.0	-0.1	-2.3
Severe depression (siblings)	0.5	0.6	1.4	-0.7	1.2	0.5	-0.6
Pack years adult smoking proportion	1.6	2.5	4.9	1.3	-1.7	-2.2	0.6
Impedance of leg (right)	1.0	4.8	14.1	-0.9	2.0	3.7	0.6
Leg fat-free mass (left)	2.8	14.9	39.4	1.5	-3.9	-6.3	-1.7
Trunk fat percentage	2.6	10.6	32.3	1.6	-2.7	-5.7	-0.4
Hand grip strength (right)	0.0	0.1	0.4	0.1	0.0	0.1	-0.6
Townsend deprivation index at recruitment	0.1	0.1	0.2	0.2	0.3	-0.5	0.2
Current tobacco smoking	1.6	2.6	7.7	0.8	-1.4	-2.8	-0.2
Average weekly fortified wine intake	1.4	1.6	3.6	0.4	-1.9	-1.5	-0.5
Maternal smoking around birth	1.3	1.8	2.6	-1.5	0.5	-1.5	-1.6
Fed-up feelings	0.2	0.3	0.8	-0.4	0.5	-0.9	0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.2	4.8	-0.1	-0.3	-2.2	-0.3
Relative age voice broke	0.5	0.7	1.5	-0.5	-1.2	-0.8	-0.8
Taking other prescription medications	0.6	0.9	1.5	-1.2	1.0	-0.2	-1.0
Age when periods started (menarche)	0.4	1.0	2.0	-0.1	-1.4	-1.2	-0.7
Bilateral oophorectomy (both ovaries removed)	0.1	0.2	0.4	-0.1	-0.2	0.7	0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	2.1	0.3	1.4	0.8	0.4
Tinnitus: Yes, but not now, but have in the past	4.2	4.5	8.0	1.8	-2.1	-2.8	1.5
Qualifications: CSEs or equivalent	1.2	1.6	6.1	0.2	-0.1	-2.5	-0.6
Serious illness, injury or assault to yourself	1.4	1.7	3.6	-1.9	1.4	-0.4	-1.1
High blood pressure	0.7	2.0	3.6	1.9	-1.3	-0.6	1.4
Hayfever, allergic rhinitis or eczema	1.1	2.3	4.4	1.4	-0.7	2.1	1.6
Multivitamins +/- minerals	3.0	3.8	7.5	-2.7	1.1	-0.0	-2.5
Stomach or abdominal pain in last month	0.8	1.0	2.2	1.5	-0.8	-0.0	1.0
Supplements: Glucosamine	2.3	3.0	4.1	-2.0	1.8	2.0	-1.0
Diverticular disease/diverticulitis (self-reported)	1.9	2.2	5.0	1.5	-1.0	0.9	2.2
Medication: Atenolol	0.9	1.1	3.0	0.7	-0.2	0.9	1.7
Medication: Levothyroxine sodium	0.7	1.1	1.9	-0.6	-0.7	-1.4	-1.3
Sitting height	0.4	2.7	5.9	1.9	-2.4	-0.2	1.1
Chronic bronchitis/emphysema (father)	2.6	3.1	4.1	2.0	-1.9	-1.4	1.6
High blood pressure (mother)	0.2	0.2	0.5	0.6	-0.3	-0.2	0.7
Body mass index (BMI)	3.5	15.0	46.9	2.2	-2.9	-6.8	-0.2
Impedance of leg (left)	1.4	6.8	18.6	-1.4	2.5	4.3	0.6
Leg predicted mass (left)	2.9	15.2	39.9	1.6	-4.0	-6.3	-1.6
Trunk fat mass	3.4	14.5	42.4	1.9	-3.4	-6.5	-0.8
Waist circumference	2.4	8.9	26.8	1.4	-2.5	-5.2	-0.7
Number of incorrect matches in round	3.7	6.1	10.0	-2.5	3.2	2.8	-0.7
Past tobacco smoking	0.4	0.8	2.3	0.9	0.1	0.1	1.5
Alcohol usually taken with meals	3.6	5.8	9.9	-3.1	2.4	1.8	-2.0
Nervous feelings	0.7	1.2	2.4	-1.5	0.1	0.6	-1.5
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.3	0.3	-0.5	-0.5	0.3
Hearing difficulty/problems with background noise	1.1	1.7	3.0	-1.7	1.0	1.1	-1.2
Hair/balding pattern: Pattern 2	0.1	0.1	0.3	-0.1	0.5	0.1	-0.5
Had menopause	1.2	1.5	2.5	-1.3	0.9	1.6	-0.9
Had other major operations	0.9	1.0	1.9	-1.2	0.9	1.4	-0.4
Forced vital capacity (FVC)	0.1	0.3	0.8	0.2	-0.6	-0.9	0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.0	4.3	-0.6	2.1	1.8	0.0
Ever unenthusiastic/disinterested for a whole week	1.2	1.5	2.6	-1.1	0.0	-1.5	-1.6
Qualifications: None of the above	2.4	5.2	11.4	1.7	-2.1	-3.4	1.4
Financial difficulties in last 2 years	1.5	2.1	5.2	-1.3	2.3	1.2	-0.1
Mouth/teeth dental problems	0.6	0.9	2.7	0.9	-1.6	0.3	0.2
Heart attack	0.7	0.9	1.8	1.1	-0.4	-0.6	1.3
Allergy	0.9	2.2	3.6	-1.5	0.7	-1.6	-1.9
Pain all over the body in last month	0.8	0.8	1.3	1.0	-1.0	-1.1	0.4
Diabetes (self-reported)	0.4	0.6	1.7	-0.3	0.8	-1.3	-0.3
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	1.2	-0.6	-0.2	0.5	-1.1
Medication: Ramipril	1.0	1.3	1.9	1.1	-1.4	-1.3	0.8
Medication: Simvastatin	2.7	3.9	6.2	1.8	-2.0	-2.5	1.4
Fluid intelligence score	1.1	2.4	5.4	-1.4	0.3	1.4	-2.3
Illnesses of siblings	2.3	3.2	4.4	-1.6	1.7	2.1	-1.7
Neuroticism score	0.5	0.9	1.5	-1.2	0.3	-0.8	-1.2
Weight	3.3	16.0	45.0	2.0	-3.8	-6.7	-0.9
Impedance of arm (right)	1.1	4.9	11.4	-2.1	1.7	3.4	-1.0
Arm fat percentage (right)	3.0	11.7	37.7	1.4	-2.5	-6.1	-0.7
Trunk fat-free mass	1.7	9.6	22.0	1.5	-3.6	-4.7	-1.2
Hip circumference	2.6	11.1	29.8	1.8	-3.3	-5.5	-0.4
Time employed in main current job	2.7	3.1	4.9	2.2	-2.2	-1.6	0.5
Alcohol intake versus 10 years previously	0.4	0.7	2.4	-0.3	-0.3	-1.6	0.0
Father’s age at death	0.8	1.0	1.7	-1.3	1.2	1.0	-0.1
Worrier / anxious feelings	0.2	0.3	1.1	-0.1	-0.1	-1.1	-0.4
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.1	0.3	-0.6	0.0	-0.2	-0.4
Falls in the last year	2.5	3.4	7.0	2.1	-1.2	-0.8	2.6
Hair/balding pattern: Pattern 3	0.3	0.4	1.0	0.7	0.0	1.0	0.4
Number of live births	0.3	0.4	1.0	-0.1	0.7	1.0	0.5
Forced expiratory volume in 1-second (FEV1)	0.3	0.9	2.7	0.5	-0.8	-1.6	-0.0
Pulse rate	1.9	3.2	5.9	-0.2	1.9	2.4	1.8
Happiness	1.4	1.7	2.6	-1.5	0.8	1.1	-1.6
Noisy workplace	2.3	2.8	7.9	-1.0	1.0	-2.8	-1.1
Qualifications: A levels/AS levels or equivalent	1.5	3.3	7.5	-1.6	1.5	2.7	-1.0
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.1	1.6	-1.1	0.3	-1.1	-1.3
Mouth/teeth dental problems: Dentures	0.5	0.9	1.3	1.1	-0.8	-0.6	1.1
Asthma	0.7	1.3	3.2	0.6	-1.8	-1.4	0.1
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.3	0.2	0.6	0.2	0.3
Medication: Cholesterol lowering	0.8	1.2	1.9	1.3	-0.7	-0.9	1.4
Depression (self-reported)	2.3	2.8	6.1	-1.5	0.3	-1.7	-2.5
Medication: Lansoprazole	0.3	0.3	0.6	0.4	0.5	0.6	0.8
Prospective memory result	0.4	0.5	1.8	0.3	0.0	-0.4	1.4
Lung cancer (father)	0.2	0.2	0.3	0.6	-0.4	-0.5	0.4
Illnesses of mother	0.1	0.1	0.4	0.1	0.0	0.6	0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.0	0.1	0.3	0.2	-0.2	-0.6	0.0
Pulse wave Arterial Stiffness index	1.9	2.2	3.3	-1.8	1.2	0.9	-1.8
Impedance of arm (left)	0.8	3.7	10.8	-1.6	1.2	3.3	-0.3
Arm fat mass (right)	3.9	16.0	47.9	1.9	-3.5	-6.9	-0.8
Trunk predicted mass	1.7	9.6	22.2	1.5	-3.5	-4.7	-1.3
Standing height	0.2	2.3	5.5	-0.2	-2.4	-0.5	-1.8
Length of working week for main job	2.4	2.7	6.6	1.3	-1.6	-2.6	-0.1
Exposure to tobacco smoke at home	0.5	0.5	1.2	-0.2	1.1	0.9	0.5
Breastfed as a baby	0.7	0.9	1.7	-1.1	0.8	-0.3	-1.3
Tense / ‘highly strung’	0.7	1.2	2.5	-1.6	0.6	-0.4	-1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	2.0	3.0	6.3	-2.5	1.7	0.5	-1.7
Hair/balding pattern: Pattern 4	0.4	1.1	2.1	-0.9	-0.1	-1.2	-1.4
Birth weight of first child	0.9	1.6	3.9	-0.7	-0.9	-1.1	-2.0
Peak expiratory flow (PEF)	0.9	2.1	5.4	1.0	-1.3	-2.3	-0.5
Pulse wave reflection index	3.2	4.0	9.1	-2.3	1.3	-0.0	-3.0
Ever highly irritable/argumentative for 2 days	3.7	4.4	13.2	-0.1	-1.3	-3.6	-1.6
Loud music exposure frequency	0.6	0.6	1.5	0.9	-0.4	-0.1	1.2
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	3.8	-0.1	0.6	1.9	-0.2
Mouth/teeth dental problems: Bleeding gums	0.8	1.1	2.3	-0.6	1.5	1.3	0.4
Blood clot in the leg (DVT)	0.6	0.8	1.5	-0.4	0.1	-1.2	-1.2
Medication: Paracetamol	0.1	0.1	0.3	-0.3	0.5	-0.3	0.1
Headache pain in last month	0.4	0.6	0.9	-0.4	1.0	0.8	0.8
Medication for cholesterol, blood pressure or diabetes	1.8	3.0	4.9	-2.2	1.7	1.3	-1.6
Glaucoma (self-reported)	4.2	5.0	7.6	-2.4	2.4	0.7	-2.8
Gout (self-reported)	0.1	0.2	0.3	0.5	-0.5	-0.6	0.1
Hypothyroidism/myxoedema (self-reported)	1.0	1.9	3.0	-0.3	-1.7	-1.7	-1.3
Medication: Amlodipine	0.2	0.2	0.5	-0.3	0.7	0.1	-0.5
Medication: Ventolin 100micrograms inhaler	0.4	0.6	0.8	-0.8	0.7	0.9	-0.6
Birth weight	0.7	1.6	3.2	-1.1	1.8	1.2	-0.5
Chronic bronchitis/emphysema (mother)	0.3	0.4	0.7	-0.5	-0.0	-0.8	-0.7
High blood pressure (siblings)	0.2	0.3	0.6	0.4	-0.4	-0.5	0.7
Forced vital capacity (FVC), Best measure	0.0	0.2	0.4	0.0	-0.2	0.7	0.4
Body fat percentage	2.8	11.0	35.3	1.6	-2.4	-5.9	-0.4
Leg fat percentage (right)	3.2	11.4	37.7	1.8	-2.2	-6.1	-0.2
Arm fat-free mass (right)	2.6	13.4	34.6	1.9	-3.8	-5.9	-1.1
Exposure to tobacco smoke outside home	0.9	1.2	2.4	1.6	-0.5	-0.8	1.1
Comparative body size at age 10	1.5	4.1	10.2	1.4	-2.1	-3.2	0.2
Number of full brothers	0.4	0.6	0.9	-0.7	1.0	0.3	-0.8
Worry too long after embarrassment	1.6	2.7	3.9	-1.9	2.0	-0.2	-1.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.0	-1.0	0.6	0.6	-0.8
Wheeze or whistling in the chest in last year	0.4	0.7	1.7	-0.6	0.4	-1.3	-0.9
Number of children fathered	1.0	1.1	1.9	-1.0	1.2	-0.3	-1.4
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	1.8	0.5	-0.6	-1.4	-0.6
Age at first live birth	0.2	0.4	1.0	-0.3	-0.7	0.4	-1.0
Pulse wave peak to peak time	1.8	2.2	3.2	1.8	-1.3	-1.0	1.6
Health satisfaction	0.5	0.6	1.8	-0.6	0.5	1.3	0.2
Shortness of breath walking on level ground	0.3	0.3	0.6	-0.4	0.8	0.7	0.3
Qualifications: College or University degree	1.1	3.4	11.8	-1.3	0.4	3.4	-0.2
Eye problems/disorders: None of the above	0.8	0.9	2.4	0.6	-1.6	-0.6	0.8
Mouth/teeth dental problems: Loose teeth	0.9	1.1	3.0	-0.8	1.7	0.8	-0.0
Emphysema/chronic bronchitis	0.1	0.1	0.1	0.3	0.2	0.3	0.1
Medication for pain relief, constipation, heartburn	0.3	0.5	0.9	0.5	-1.0	0.9	0.4
Neck or shoulder pain in last month	0.9	1.3	2.7	0.5	0.4	1.6	1.5
Medication: Blood pressure	0.7	1.3	2.0	1.4	-1.0	-0.9	1.2
Angina (self-reported)	0.1	0.1	0.3	-0.1	0.6	-0.4	0.3
Migraine (self-reported)	1.3	1.6	3.6	-0.4	1.4	1.9	0.8
Medication: Ibuprofen	0.2	0.2	0.4	0.6	0.2	0.2	0.7
Medication: Allopurinol	0.4	0.6	1.1	0.7	-0.7	-1.1	0.6
Medication: Omeprazole	0.0	0.0	0.1	0.2	-0.4	0.1	0.1
Medication: Seretide 50 evohaler	0.7	0.8	1.5	-1.1	0.1	-0.6	-1.2
Mean time to correctly identify matches	3.5	6.6	10.3	0.9	2.4	3.2	3.1
Heart disease (mother)	0.3	0.3	0.5	0.3	0.7	0.7	0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	1.5	0.6	0.2	1.0	1.2
Whole body fat mass	3.7	15.5	46.5	1.9	-3.4	-6.8	-0.7
Leg fat mass (right)	3.8	14.7	46.5	1.9	-2.9	-6.8	-0.6
Arm predicted mass (right)	2.6	13.4	33.8	2.0	-3.9	-5.8	-0.9
Pulse rate, automated reading	0.7	2.2	4.0	-0.5	1.3	1.7	2.0
Alcohol intake frequency.	4.5	10.5	24.4	2.5	-3.4	-4.9	0.6
Comparative height size at age 10	0.4	2.1	7.0	1.1	-2.6	-0.4	0.3
Number of full sisters	0.3	0.3	1.2	0.4	-0.1	-1.1	0.1
Suffer from ‘nerves’	1.3	2.1	4.2	-1.5	1.2	2.0	-0.5
Overall health rating	0.5	1.1	2.2	-0.9	0.1	-1.5	-1.2
Chest pain or discomfort	0.5	0.7	2.0	0.9	-0.1	-0.1	1.4
Had major operations	0.3	0.3	0.6	-0.1	-0.4	-0.8	-0.7
Age at last live birth	0.9	1.4	3.1	0.3	-1.8	-0.9	-1.2
Family relationship satisfaction	3.3	4.0	6.7	-2.6	1.6	1.1	-2.4
Leg pain on walking	0.4	0.6	0.7	0.6	-0.8	-0.8	0.8
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	3.6	1.1	-0.1	-1.9	0.1
Commuting to job workplace: Car/motor vehicle	1.8	2.1	5.4	1.6	-0.5	0.3	2.3
Illness, injury, bereavement, stress in last 2 years	1.2	1.5	2.7	1.0	-1.0	1.6	1.1
Medication: Aspirin	1.0	1.3	2.7	-0.9	0.9	-1.7	-1.0
Supplements: Vitamin C	0.5	0.6	1.6	1.2	0.0	-0.2	0.9
Knee pain experienced in last month	0.3	0.4	0.9	0.2	-0.7	-0.6	0.9
Hypertension (Self-reported)	0.6	1.7	3.1	1.8	-1.2	-0.6	1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.3	-0.6	0.5	0.3	-0.3
Illnesses of father: Heart disease	1.1	1.5	2.6	-1.2	1.6	1.4	-0.2
Illnesses of siblings: Diabetes	0.2	0.2	0.4	-0.4	0.4	-0.6	-0.4
Smoking status: Previous	0.4	0.6	2.0	-0.6	-0.2	0.1	-1.4
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.4	-0.1	-0.7	-0.4	-0.6
Whole body fat-free mass	2.3	13.2	32.4	1.7	-4.0	-5.7	-1.4
Leg fat-free mass (right)	2.5	13.3	34.7	1.4	-3.8	-5.9	-1.6
Arm fat percentage (left)	3.2	12.6	40.3	1.6	-2.7	-6.3	-0.5
Average weekly red wine intake	0.3	0.4	0.5	0.6	-0.6	0.5	0.7
Handedness (chirality/laterality): Left-handed	0.8	1.0	2.4	-0.2	0.4	1.6	1.1
Mood swings	0.6	1.2	2.7	-1.1	1.6	0.8	0.2
Loneliness, isolation	1.3	1.8	3.5	-1.9	1.5	0.5	-1.1
Long-standing illness, disability or infirmity	2.2	3.3	4.1	2.0	-1.8	-1.8	1.7
Ever had bowel cancer screening	0.1	0.1	0.2	0.1	-0.1	-0.4	0.3
Diabetes diagnosed by doctor	1.0	1.6	6.1	0.3	-0.0	-2.5	-0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	1.4	-1.2	0.5	0.7	-0.5
Friendships satisfaction	4.8	5.9	7.4	-2.6	1.9	2.7	-2.5
Qualifications: nursing, teaching	0.6	1.0	2.0	0.9	-1.4	-0.0	1.0
Commuting to job workplace: Walk	0.9	1.0	2.4	-1.1	-0.0	-0.6	-1.5
Eye problems/disorders: Cataract	0.2	0.2	0.5	0.7	-0.2	-0.4	0.2
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.5	0.2	0.2	-0.4	0.7
Medication for cholesterol	0.1	0.2	0.5	-0.2	-0.1	-0.0	-0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	1.6	-0.2	0.0	1.3	-0.6
Back pain experienced in last month	0.3	0.4	0.8	0.9	-0.4	-0.3	0.7
Mineral and other dietary supplements	0.6	0.8	1.7	1.3	-0.7	-0.1	1.1
Breast cancer (self-reported)	0.1	0.1	0.2	0.4	0.4	0.1	-0.4
Asthma (self-reported)	0.3	0.7	1.8	0.3	-1.3	-0.9	0.2
Osteoporosis (self-reported)	0.5	0.6	1.0	0.8	-1.0	0.7	0.5
Osteoarthritis (self-reported)	0.3	0.4	1.0	0.3	-0.2	-1.0	0.6
Medication: Aspirin	0.8	1.1	3.6	-0.4	0.3	-1.9	-0.5
Medication: Gliclazide	2.8	3.2	7.5	1.2	-1.9	-2.7	0.2
Illnesses of father: None of the above (group 1)	0.0	0.0	0.1	-0.1	-0.0	0.2	-0.3
Smoking status: Current	1.2	1.9	5.7	0.6	-1.1	-2.4	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	1.2	0.9	-0.0	0.2	1.1
Whole body water mass	2.1	12.2	30.0	1.6	-3.8	-5.5	-1.5
Leg predicted mass (right)	2.4	13.0	33.9	1.3	-3.7	-5.8	-1.6
Arm fat mass (left)	3.8	15.5	46.5	1.9	-3.3	-6.8	-0.7
Number of self-reported non-cancer illnesses	0.1	0.2	0.4	0.2	-0.6	-0.7	0.2
Average weekly champagne plus white wine intake	4.0	5.5	8.2	-2.4	2.9	2.8	-0.5
Miserableness	0.7	1.2	2.1	-1.4	1.2	0.7	-1.0
Guilty feelings	3.1	4.7	8.8	-3.0	2.1	0.3	-2.3
Wears glasses or contact lenses	0.9	1.1	2.3	-1.5	0.8	0.1	-1.1
Ever taken oral contraceptive pill	3.7	4.1	7.1	-1.9	2.1	2.7	-1.1
Hearing aid user	1.0	1.2	2.6	0.8	-1.1	-1.6	-0.6
Mother’s age at death	0.1	0.1	0.2	0.3	-0.4	-0.3	0.2
Financial situation satisfaction	1.8	2.2	4.2	-1.2	1.7	2.0	-0.5
Tinnitus: Yes, now most or all of the time	0.1	0.2	0.3	-0.3	0.1	-0.5	-0.5
Commuting to job workplace: Public transport	0.7	0.8	2.8	0.5	0.0	1.7	0.3
Eye problems/disorders: Glaucoma	2.1	2.5	5.2	-1.7	1.4	-0.2	-2.3
Medication: Blood pressure	0.4	0.8	1.5	1.2	-0.5	-0.3	1.2
Pain type(s) experienced in last month: Hip pain	0.4	0.5	0.7	-0.1	0.9	0.9	0.8
Supplements: Fish oil (including cod liver oil)	0.9	1.1	1.8	-1.4	1.3	0.6	-0.8
High cholesterol (Self-reported)	0.7	1.2	3.4	0.2	-1.2	-1.9	-0.2
Medication: Bendroflumethiazide	1.3	1.9	4.1	2.0	-1.0	-0.1	1.6
Medication: Paracetamol	0.1	0.2	0.6	0.1	0.1	-0.8	0.5
Medication: Lisinopril	0.8	1.0	2.3	0.7	-1.0	-1.5	-0.6
Medication: Atorvastatin	1.7	2.1	3.4	-1.7	1.8	0.8	-1.3
Illnesses of father: High blood pressure	0.3	0.4	0.8	0.0	-0.9	-0.8	-0.5
Alcohol drinker status: Never	2.8	3.4	4.5	2.1	-2.1	-1.7	1.4
Ever smoked	0.6	1.0	2.3	-1.3	0.2	0.1	-1.5
Basal metabolic rate	2.6	14.3	37.2	1.7	-3.9	-6.1	-1.4
Leg fat percentage (left)	3.0	10.9	36.8	1.7	-2.0	-6.1	-0.1
Arm fat-free mass (left)	2.1	10.7	28.5	1.5	-3.3	-5.3	-1.2
Number of operations (self-reported)	0.1	0.1	0.2	-0.3	-0.4	0.4	-0.3
Average weekly beer plus cider intake	0.1	0.2	0.5	-0.2	-0.2	-0.7	-0.2
Irritability	1.6	2.8	5.7	-1.7	0.7	-1.4	-2.4
Risk taking	2.1	3.1	7.2	-1.8	2.7	1.1	-0.9
Ever had prostate specific antigen (PSA) test	0.5	0.6	1.3	-0.6	0.8	1.1	0.4
Fractured/broken bones in last 5 years	2.6	3.4	5.7	-2.1	1.6	-0.7	-2.4
Age started oral contraceptive pill	0.6	0.7	1.8	-0.4	-0.8	-0.6	-1.4
Diastolic blood pressure, automated reading	2.3	7.0	8.5	2.9	-2.8	-2.4	2.6
Ever depressed for a whole week	1.6	2.0	3.8	-1.9	0.7	-0.6	-1.8
Unable to work because of sickness or disability	0.1	0.1	0.2	-0.4	0.3	-0.5	-0.2
Commuting to job workplace: Cycle	1.5	1.8	3.0	-1.6	1.1	0.2	-1.7
Myopia	0.2	0.3	0.7	-0.3	0.3	0.6	0.8
Vascular/heart problems diagnosed by doctor	0.6	1.6	2.4	-1.6	1.4	0.7	-1.1
Cholesterol lowering medication	0.8	1.1	3.5	0.3	-1.0	-1.9	-0.1
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.2	0.3	-0.4	-0.2	-0.0
Pain experienced in last month	0.5	0.9	2.0	-0.7	-0.7	-0.8	-1.4
Supplements: Calcium	0.6	0.7	1.3	-1.0	-0.1	-0.6	-1.1
Basal cell carcinoma (self-reported)	1.8	2.1	4.0	-2.0	1.5	0.2	-1.5
Heart attack/myocardial infarction (self-reported)	0.6	0.8	1.4	1.0	-0.4	-0.7	1.2
Deep venous thrombosis (DVT) (self-reported)	0.5	0.7	1.7	-0.2	-0.1	-1.3	-1.0
Heart disease (siblings)	0.8	1.0	3.5	0.4	-0.3	-1.9	-0.4
Alcohol drinker status: Previous	1.3	1.5	3.1	0.9	-1.4	-1.8	0.2
Pack years of smoking	1.3	2.0	3.8	1.1	-1.5	-2.0	0.7
Impedance of whole body	1.1	5.6	16.1	-1.5	1.9	4.0	0.1
Leg fat mass (left)	3.7	14.6	46.5	1.9	-2.9	-6.8	-0.6
Arm predicted mass (left)	2.4	12.1	31.9	1.7	-3.5	-5.7	-1.3