TWAS
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Models
Genes
Traits
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Traits
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Leg fat percentage (left)
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chr11:7,714,238-9,408,426
Best TWAS P=1.88e-10 · Best GWAS P=4.17e-11 conditioned to 0.00153
7.8M
8M
8.2M
8.4M
8.6M
8.8M
9M
9.2M
9.4M
0
2
4
6
8
10
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
4
The Cancer Genome Atlas
Thyroid Carcinoma
STK33
0.14
0.08
lasso
6
0.10
1.0e-09
-6.0
6.4
1.9e-10
-0.66
0.04
0.96
TRUE
1
CommonMind
Brain Pre-frontal Cortex
STK33
0.18
0.18
lasso
9
0.20
3.8e-24
-4.9
6.1
1.4e-09
-0.83
0.85
0.15
FALSE
2
GTEx
Brain Caudate basal ganglia
RP11-152H18.3
0.23
0.01
enet
1
0.06
1.1e-02
-5.8
-5.8
7.2e-09
0.69
0.05
0.65
FALSE
3
The Cancer Genome Atlas
Kidney Renal Clear Cell Carcinoma
STK33
0.05
0.03
lasso
2
0.03
2.5e-04
-5.4
5.3
8.6e-08
-0.53
0.42
0.21
FALSE