Best TWAS P=1.88e-10 · Best GWAS P=4.17e-11 conditioned to 0.00153
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | STK33 | 0.18 | 0.18 | lasso | 9 | 0.20 | 3.8e-24 | -4.9 | 6.1 | 1.4e-09 | -0.83 | 0.85 | 0.15 | FALSE |
| 2 | GTEx | Brain Caudate basal ganglia | RP11-152H18.3 | 0.23 | 0.01 | enet | 1 | 0.06 | 1.1e-02 | -5.8 | -5.8 | 7.2e-09 | 0.69 | 0.05 | 0.65 | FALSE |
| 3 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | STK33 | 0.05 | 0.03 | lasso | 2 | 0.03 | 2.5e-04 | -5.4 | 5.3 | 8.6e-08 | -0.53 | 0.42 | 0.21 | FALSE |
| 4 | The Cancer Genome Atlas | Thyroid Carcinoma | STK33 | 0.14 | 0.08 | lasso | 6 | 0.10 | 1.0e-09 | -6.0 | 6.4 | 1.9e-10 | -0.66 | 0.04 | 0.96 | TRUE |