Hub : Genes

PRDM4

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0720	0.0220	7.4e-06	0.081	0.038	0.067	0.046	0.071	4.9e-10	2.0e-05	1.4e-08	2.6e-06	5.0e-09
2	GTEx	Heart Left Ventricle	0.1828	0.0537	1.2e-04	0.046	NA	0.042	NA	0.053	1.8e-03	NA	2.6e-03	NA	8.6e-04
3	GTEx	Whole Blood	0.1040	0.0350	4.2e-04	0.075	NA	0.031	NA	0.051	1.8e-07	NA	6.4e-04	NA	1.8e-05
4	YFS	Blood	0.0519	0.0131	2.3e-12	0.057	0.044	0.058	0.054	0.060	4.7e-18	3.1e-14	1.8e-18	3.6e-17	5.4e-19
5	TCGA	Breast Invasive Carcinoma	0.0115	0.0077	9.5e-03	0.012	0.007	0.001	NA	0.008	1.3e-03	1.2e-02	1.6e-01	NA	6.3e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.4	0.6	2.3	0.1	-1.5	-0.0	0.9	-0.4
Bipolar Disorder or Schizophrenia	0.0	0.1	0.3	-0.5	0.2	0.2	-0.1	0.4
Depressed Affect (Nagel 2018)	1.2	2.6	4.5	2.0	-1.7	-2.1	-1.0	-0.6
Depression (Nagel 2018)	0.2	0.3	0.5	0.5	0.7	0.0	-0.0	0.7
Intelligence (Savage-Jansen 2018)	1.9	6.0	9.5	-3.0	1.3	3.1	1.5	2.8
Neuroticism (Nagel 2018)	1.0	2.3	3.4	1.3	-1.4	-1.8	-1.8	-1.0
Schizophrenia (2018)	0.4	0.8	2.2	-0.8	1.5	0.3	-0.8	0.8
Schizophrenia vs Biploar Disorder	2.8	3.6	5.6	-1.9	2.2	1.8	1.1	2.4
Worry (Nagel 2018)	0.9	2.0	3.8	0.6	-1.7	-1.4	-2.0	-0.8
Alzheimer’s Disease (in mother)	2.9	3.4	7.2	-2.5	-0.6	1.6	0.5	2.7
Alzheimer’s Disease (in father)	0.7	0.8	3.7	-0.0	0.3	0.0	-1.9	-0.0
Alzheimer’s Disease (including proxy)	1.2	1.7	4.0	-2.0	-0.2	1.2	-0.4	1.8
Crohns Disease (2017)	0.5	1.1	1.9	1.1	0.3	-1.1	1.0	-1.4
Irritable Bowel Disease (IBD)	2.6	6.1	10.5	3.2	1.3	-3.1	-0.4	-2.9
Ulcerative Colitis (UC)	4.7	8.8	14.5	3.8	2.1	-3.5	-1.7	-3.1
Major Depression (MDD)	2.0	2.4	3.9	2.0	-1.6	-1.7	-1.1	-1.2
Reaction Time	0.6	1.2	2.0	-1.4	-1.0	1.3	0.7	0.9
Verbal and Numeric Reasoning (VNR)	2.3	5.6	7.7	-2.7	2.0	2.8	1.8	2.5
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Ovarian Cancer	3.2	4.2	6.2	-2.5	1.0	2.5	1.3	2.5
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.5	0.7	1.5	-0.5	-1.2	0.7	0.7	0.9
Bipolar Disorder (2011)	0.9	0.9	1.3	-0.9	1.1	1.0	0.3	1.1
Body Mass Index (BMI) (2010)	0.9	1.2	4.5	0.9	-2.1	-0.4	0.8	-0.4
Coronary Artery Disease (CAD)	1.2	1.4	2.8	1.3	-1.2	-1.0	0.6	-1.7
Crohns Disease (2012)	1.0	1.6	3.3	1.8	-1.1	-1.5	-0.1	-1.1
Mean Putamen Volume	0.2	0.3	1.0	-0.3	-0.3	0.4	1.0	0.2
Fasting Glucose	0.3	0.3	1.7	-0.1	0.1	-0.0	1.3	-0.1
HbA1C	0.2	0.2	0.5	-0.2	0.7	0.3	-0.3	0.3
HDL Cholesterol	0.7	1.2	3.6	0.7	1.9	-0.8	-1.1	-0.5
LDL Cholesterol	0.8	1.2	2.6	1.6	-0.6	-1.5	-0.6	-0.9
Lupus	1.3	2.0	3.6	1.8	0.5	-1.2	-1.2	-1.9
Neuroticism (2016)	0.5	0.7	1.7	0.8	-1.3	-0.8	-0.5	-0.6
Primary Biliary Cirrhosis	0.5	0.8	1.1	0.7	-1.0	-0.8	0.8	-1.1
Rheumatoid Arthritis	1.3	1.8	4.4	0.6	2.1	-0.7	1.4	-1.2
Schizophrenia (2014)	0.4	0.9	2.9	-0.6	1.7	0.3	-0.9	0.7
Triglycerides	0.1	0.1	0.3	-0.3	0.3	0.5	0.2	0.5
Type 2 Diabetes (T2D) (2012)	1.9	2.2	4.0	2.0	-1.6	-1.6	-1.2	-0.5
Ulcerative Colitis	7.1	10.2	18.2	4.3	1.0	-3.9	-2.2	-3.5
Blood Eosinophil Count	0.0	0.2	0.5	0.0	-0.7	0.0	0.7	0.1
Blood Platelet Count	0.0	0.2	0.8	-0.2	-0.9	0.2	-0.1	-0.4
Blood Red Count	0.1	0.5	1.9	-0.4	-1.4	0.4	0.4	-0.3
Blood White Count	0.6	4.5	10.0	-1.9	-1.0	2.4	3.2	1.4
Heel T-Score	0.2	1.5	4.3	-0.5	2.1	0.1	-1.6	-0.6
BMI	3.2	18.4	26.4	4.5	-5.1	-4.5	-2.0	-4.6
Height	2.2	42.3	70.1	8.2	2.7	-8.4	-4.7	-6.7
Waist Hip Ratio (WHR)	0.1	0.3	1.1	-0.4	-1.0	0.4	-0.1	-0.2
Systolic Blood Pressure	0.2	1.0	2.3	1.0	-0.3	-1.2	-0.1	-1.5
Smoking Status	0.8	2.0	8.8	0.5	-3.0	-0.5	-0.7	-0.3
Allergy or Eczema	0.1	0.3	0.8	0.1	-0.7	-0.3	0.5	-0.9
Cardiovascular Disease	0.7	2.3	10.0	0.2	-0.5	-1.0	-3.2	-0.4
Hypothyroidism (self reported)	0.6	1.4	2.6	1.4	-1.6	-1.3	0.8	0.4
Respiratory disease	0.4	0.9	1.3	1.1	-0.4	-1.2	1.0	-1.0
Type 2 Diabetes (T2D) (2018)	0.2	0.5	1.3	0.4	-1.1	-0.8	0.3	-0.3
Lung FEV1/FVC ratio	0.4	2.2	3.5	-1.6	-1.6	1.4	0.3	1.9
Lung FVC	0.7	3.7	12.8	-1.0	3.6	0.9	-1.3	1.5
Neuroticism	1.9	4.5	7.1	2.2	-1.9	-2.7	-2.2	-1.4
Chronotype (morning person)	1.2	2.8	4.5	1.9	-1.9	-2.1	-0.4	-1.5
Hair Pigment	0.4	10.9	14.9	3.9	-2.6	-3.9	-2.0	-3.7
Tanning	0.2	2.0	2.8	1.4	-1.7	-1.5	-1.3	-1.0
Hand grip strength (left)	0.3	0.9	2.0	0.7	1.4	-1.0	-0.7	-0.7
Number of treatments/medications taken	1.9	3.4	4.7	1.9	-2.2	-2.1	-2.1	-0.5
Average weekly spirits intake	0.4	0.5	0.6	0.7	-0.8	-0.8	-0.6	-0.7
Sensitivity / hurt feelings	0.7	1.1	2.0	1.1	-1.0	-1.1	-0.4	-1.4
Frequency of depressed mood in last 2 weeks	0.5	0.7	1.9	-0.6	-0.3	0.7	-0.6	1.4
Hearing difficulty/problems: Yes	0.2	0.3	1.1	0.3	-1.0	0.1	0.1	-0.5
Relative age of first facial hair	0.3	0.6	1.0	0.7	-1.0	-0.6	0.3	-1.0
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.2	0.4	0.1	-0.4	0.3	-0.3
Ever used hormone-replacement therapy (HRT)	1.2	1.6	2.8	1.0	-1.7	-1.3	0.5	-1.5
Ever had hysterectomy (womb removed)	0.3	0.4	1.1	-0.3	-0.8	-0.2	-1.1	0.1
Systolic blood pressure, automated reading	0.5	1.4	3.2	1.8	-0.5	-1.6	0.2	-1.1
Eye problems/disorders: Diabetes related eye disease	0.7	0.7	3.1	-0.1	-0.0	-0.2	-1.8	0.7
Angina	0.7	0.9	3.6	0.6	-1.9	-0.5	-0.3	0.4
Medication for hormone replacement therapy	0.2	0.3	1.1	-0.2	1.1	-0.0	0.3	0.3
Vitamin and mineral supplements	4.1	5.6	9.7	-2.8	0.9	3.1	2.1	2.3
Supplements: Zinc	0.6	0.7	1.4	0.6	-1.1	-0.6	-1.2	-0.2
Medication: Co-codamol	0.6	0.7	1.2	-0.6	-0.8	0.8	0.8	1.1
Medication: Metformin	0.2	0.2	0.6	-0.1	0.5	-0.3	-0.8	0.2
Diabetes (father)	0.2	0.3	0.6	0.7	0.6	-0.8	-0.2	-0.3
Diabetes (mother)	2.2	2.8	4.1	1.9	-1.5	-2.0	-1.2	-1.7
Severe depression (siblings)	0.1	0.1	0.2	-0.0	-0.4	-0.1	0.0	0.4
Pack years adult smoking proportion	0.1	0.2	0.4	-0.6	0.3	0.5	0.6	0.0
Impedance of leg (right)	0.1	0.4	0.7	0.8	0.5	-0.7	0.8	-0.4
Leg fat-free mass (left)	2.7	14.1	21.9	4.6	-1.5	-4.7	-2.6	-4.3
Trunk fat percentage	9.4	37.8	60.2	7.6	-3.8	-7.8	-3.5	-6.7
Hand grip strength (right)	0.4	1.0	2.6	0.4	1.6	-0.9	-0.9	-0.8
Townsend deprivation index at recruitment	3.3	4.6	7.9	-2.3	-0.9	2.8	2.1	2.2
Current tobacco smoking	0.2	0.4	1.4	0.3	-1.2	-0.5	0.2	-0.3
Average weekly fortified wine intake	3.7	4.4	8.1	-2.6	0.7	2.9	1.4	2.1
Maternal smoking around birth	0.4	0.5	1.8	0.5	-0.5	-0.5	-1.4	0.1
Fed-up feelings	1.5	2.7	6.3	2.5	-0.4	-2.1	-1.5	-0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.7	0.8	0.8	-0.3	-0.2	-0.1
Relative age voice broke	0.3	0.4	0.7	0.3	-0.8	-0.5	-0.8	-0.8
Taking other prescription medications	1.6	2.5	7.8	1.4	-2.8	-1.5	-0.5	0.4
Age when periods started (menarche)	2.0	4.7	8.7	2.5	-0.2	-2.1	2.0	-2.9
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.1	-0.3	-0.3	-0.0	0.4	0.4
Heel bone mineral density (BMD) T-score, automated (left)	1.2	2.8	8.4	1.3	2.9	-1.5	-0.8	-0.9
Tinnitus: Yes, but not now, but have in the past	0.8	0.9	1.7	-1.3	-1.3	1.0	-0.2	0.4
Qualifications: CSEs or equivalent	1.1	1.5	1.8	1.3	-1.3	-1.1	-1.0	-1.3
Serious illness, injury or assault to yourself	1.6	2.0	3.5	1.5	-0.4	-1.7	-1.9	-1.0
High blood pressure	1.6	4.4	7.2	2.3	-0.0	-2.6	-2.7	-1.7
Hayfever, allergic rhinitis or eczema	0.2	0.4	1.2	0.3	-0.8	-0.5	-0.1	-1.1
Multivitamins +/- minerals	3.4	4.3	7.6	2.5	-0.9	-2.7	-1.6	-2.0
Stomach or abdominal pain in last month	1.1	1.3	2.4	-0.8	-1.6	0.8	1.4	1.0
Supplements: Glucosamine	0.5	0.7	1.7	0.9	-0.3	-0.8	-0.0	-1.3
Diverticular disease/diverticulitis (self-reported)	1.5	1.8	2.9	1.5	-1.7	-1.2	-1.0	-1.0
Medication: Atenolol	0.8	1.0	2.9	0.7	0.8	-0.8	-1.7	-0.6
Medication: Levothyroxine sodium	0.2	0.3	1.4	-0.2	0.4	0.2	0.3	1.2
Sitting height	0.4	3.0	4.0	1.6	2.0	-1.8	-1.6	-1.6
Chronic bronchitis/emphysema (father)	0.2	0.3	0.8	0.3	-0.5	-0.0	-0.9	-0.3
High blood pressure (mother)	1.1	1.6	2.2	1.4	-0.7	-1.5	-1.0	-1.5
Body mass index (BMI)	3.5	14.9	19.3	4.4	-4.3	-4.4	-2.2	-3.7
Impedance of leg (left)	0.2	1.2	1.7	1.2	1.1	-1.3	0.4	-1.1
Leg predicted mass (left)	2.6	13.5	20.9	4.5	-1.5	-4.6	-2.5	-4.2
Trunk fat mass	9.1	39.1	62.4	7.8	-3.6	-7.9	-3.8	-6.7
Waist circumference	4.2	15.3	21.3	4.5	-4.1	-4.6	-1.7	-3.9
Number of incorrect matches in round	1.6	2.6	5.4	1.3	-2.3	-1.4	-1.8	-1.0
Past tobacco smoking	1.2	2.3	9.2	-0.1	3.0	0.2	1.0	-1.0
Alcohol usually taken with meals	1.4	2.3	5.2	0.3	2.3	-0.9	-2.1	-0.9
Nervous feelings	0.2	0.4	0.8	-0.6	-0.9	0.2	-0.5	0.8
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.2	0.5	-0.5	-0.5	0.3	-0.7	0.4
Hearing difficulty/problems with background noise	1.1	1.8	2.7	1.6	0.6	-1.4	-1.6	-1.1
Hair/balding pattern: Pattern 2	0.8	1.0	1.8	-1.4	0.7	1.0	1.2	0.6
Had menopause	0.4	0.5	1.3	-0.4	0.8	0.3	0.6	1.1
Had other major operations	3.1	3.8	5.0	1.6	-2.2	-2.1	-2.1	-1.6
Forced vital capacity (FVC)	0.6	2.5	9.7	0.2	3.1	-0.7	-1.4	-0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.7	5.6	-0.7	2.4	0.5	-1.2	0.7
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	3.4	0.4	-1.9	-0.9	0.4	-0.7
Qualifications: None of the above	0.4	0.8	3.2	0.6	-0.6	-0.1	1.8	0.5
Financial difficulties in last 2 years	0.3	0.4	1.3	-0.6	-1.1	0.7	-0.1	0.0
Mouth/teeth dental problems	0.1	0.2	1.0	-0.2	0.0	-0.1	-1.0	0.1
Heart attack	0.2	0.3	1.1	0.6	-1.0	-0.2	-0.2	0.3
Allergy	0.7	1.7	3.3	-1.4	1.1	1.4	0.1	1.8
Pain all over the body in last month	0.4	0.4	0.7	-0.8	-0.3	0.7	0.0	0.8
Diabetes (self-reported)	0.2	0.3	0.6	0.4	-0.7	-0.8	-0.2	0.0
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	0.7	-0.8	-0.8	0.7	0.2	0.1
Medication: Ramipril	1.0	1.3	4.2	-1.1	0.2	1.0	0.4	2.1
Medication: Simvastatin	0.4	0.6	2.6	-0.3	0.4	0.1	-0.4	1.6
Fluid intelligence score	0.9	1.8	2.4	-1.6	1.2	1.5	1.4	0.9
Illnesses of siblings	3.1	4.4	7.4	-2.7	1.9	2.7	0.3	1.8
Neuroticism score	1.9	4.0	5.6	2.0	-2.1	-2.4	-2.0	-1.4
Weight	5.6	27.5	43.8	6.5	-3.2	-6.6	-3.3	-5.5
Impedance of arm (right)	0.7	3.2	4.3	2.0	1.7	-2.1	-1.3	-1.7
Arm fat percentage (right)	7.0	27.5	40.1	6.3	-4.6	-6.3	-3.3	-5.1
Trunk fat-free mass	0.6	3.3	5.8	2.3	-0.8	-2.4	-1.1	-1.9
Hip circumference	4.5	19.4	31.2	5.3	-3.3	-5.6	-2.3	-4.6
Time employed in main current job	1.5	1.7	4.5	0.4	1.9	0.1	2.1	-0.1
Alcohol intake versus 10 years previously	0.4	0.6	1.6	0.2	-0.9	-0.4	-1.3	0.5
Father’s age at death	0.5	0.7	2.3	-0.7	-0.4	0.4	1.5	0.4
Worrier / anxious feelings	0.5	0.9	1.6	0.3	-1.3	-0.9	-0.8	-1.1
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.4	-0.2	-0.4	0.4	-0.4	0.6
Falls in the last year	4.5	6.0	10.1	3.2	-2.3	-3.0	-1.0	-2.2
Hair/balding pattern: Pattern 3	1.2	1.7	3.0	-1.6	0.6	1.5	-0.8	1.7
Number of live births	0.2	0.3	1.3	-0.0	0.1	-0.2	-1.1	-0.2
Forced expiratory volume in 1-second (FEV1)	0.6	2.1	6.3	0.3	2.5	-0.8	-1.7	-0.6
Pulse rate	2.1	3.5	7.7	1.1	-2.1	-1.5	-2.8	-1.3
Happiness	0.2	0.3	0.6	0.3	-0.7	-0.3	-0.8	0.4
Noisy workplace	1.3	1.6	4.0	1.2	-2.0	-1.0	1.2	0.3
Qualifications: A levels/AS levels or equivalent	0.5	1.0	3.0	-1.1	1.7	0.9	-0.0	0.2
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	0.9	-0.7	-0.5	0.9	1.0	0.5
Mouth/teeth dental problems: Dentures	0.3	0.5	1.0	0.8	0.2	-0.5	1.0	-0.7
Asthma	0.4	0.7	1.7	0.9	-0.9	-1.3	0.3	-0.6
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	2.0	0.3	-1.4	-0.5	-0.5	-0.3
Medication: Cholesterol lowering	0.4	0.6	1.5	0.0	0.6	0.2	-1.1	1.2
Depression (self-reported)	0.6	0.8	1.0	0.8	-1.0	-1.0	-0.9	-0.5
Medication: Lansoprazole	2.8	3.2	5.2	2.0	-2.3	-1.9	-1.2	-1.3
Prospective memory result	1.3	1.5	4.3	1.0	-2.1	-1.2	-0.4	-1.0
Lung cancer (father)	3.2	3.8	6.4	-2.3	1.3	2.5	1.5	1.9
Illnesses of mother	3.1	3.8	6.2	-2.1	1.2	2.5	2.0	1.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.7	7.3	1.1	2.7	-1.4	-1.4	-0.9
Pulse wave Arterial Stiffness index	0.7	0.8	3.7	-0.2	-0.0	-0.2	-1.9	0.4
Impedance of arm (left)	1.1	4.9	5.9	2.3	2.4	-2.4	-1.7	-2.1
Arm fat mass (right)	6.3	25.8	38.9	6.1	-4.2	-6.2	-3.1	-5.1
Trunk predicted mass	0.6	3.3	5.8	2.4	-0.9	-2.4	-1.1	-1.8
Standing height	1.7	16.9	28.8	5.1	1.7	-5.4	-2.7	-4.4
Length of working week for main job	1.2	1.4	2.4	1.5	0.6	-1.4	0.0	-1.5
Exposure to tobacco smoke at home	1.1	1.3	2.5	-1.2	-1.6	0.6	-0.6	1.3
Breastfed as a baby	1.0	1.3	2.4	0.7	1.0	-1.1	-1.5	-1.2
Tense / ‘highly strung’	1.2	2.1	6.1	0.2	-2.5	-0.8	-1.9	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.3	3.0	0.8	-1.7	-0.6	-1.4	-0.7
Hair/balding pattern: Pattern 4	2.9	7.1	12.8	-3.5	1.1	3.6	-0.1	3.0
Birth weight of first child	0.2	0.3	0.8	-0.7	0.9	0.3	0.4	-0.3
Peak expiratory flow (PEF)	1.5	3.5	5.5	1.5	1.6	-1.9	-1.9	-2.3
Pulse wave reflection index	0.7	0.8	2.8	-0.8	1.7	0.6	-0.3	0.6
Ever highly irritable/argumentative for 2 days	0.8	0.9	3.5	0.3	-1.9	-0.6	-0.9	-0.1
Loud music exposure frequency	0.3	0.3	1.2	-0.3	-0.4	0.1	-1.1	0.0
Qualifications: O levels/GCSEs or equivalent	2.3	3.7	11.1	0.1	3.3	-0.6	-2.5	-0.8
Mouth/teeth dental problems: Bleeding gums	0.1	0.2	0.4	-0.5	0.3	0.4	-0.6	0.3
Blood clot in the leg (DVT)	1.0	1.3	3.1	1.8	-0.4	-1.7	-0.1	-0.6
Medication: Paracetamol	0.9	1.4	2.0	1.4	-0.6	-1.3	-1.0	-1.4
Headache pain in last month	1.4	2.4	5.8	2.4	-0.5	-1.9	-0.3	-1.4
Medication for cholesterol, blood pressure or diabetes	1.4	2.4	4.9	-1.5	-1.6	1.3	2.2	0.5
Glaucoma (self-reported)	1.3	1.5	5.2	0.2	2.3	-0.2	-1.5	-0.1
Gout (self-reported)	0.3	0.4	1.8	0.1	-0.6	-0.2	1.3	0.0
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	1.8	0.4	-0.4	-0.5	0.7	1.4
Medication: Amlodipine	0.8	1.1	3.9	0.3	1.0	-0.3	-2.0	-0.6
Medication: Ventolin 100micrograms inhaler	1.6	2.1	5.0	1.0	-2.2	-1.4	-1.2	-1.0
Birth weight	0.3	0.6	1.3	0.9	1.1	-0.8	-0.6	-0.4
Chronic bronchitis/emphysema (mother)	0.1	0.2	0.7	-0.1	-0.8	0.1	-0.1	0.2
High blood pressure (siblings)	1.5	2.2	4.1	1.8	-0.5	-2.0	-0.9	-1.6
Forced vital capacity (FVC), Best measure	1.4	5.2	12.3	1.8	3.5	-2.1	-1.8	-1.7
Body fat percentage	8.7	34.3	52.9	7.2	-4.3	-7.3	-3.4	-6.1
Leg fat percentage (right)	6.1	22.2	31.3	5.5	-4.9	-5.6	-2.2	-4.5
Arm fat-free mass (right)	1.4	7.3	11.4	3.3	-1.5	-3.4	-1.5	-3.2
Exposure to tobacco smoke outside home	0.3	0.3	1.5	0.1	-1.2	-0.2	0.3	-0.3
Comparative body size at age 10	0.1	0.2	1.0	-0.2	0.1	0.2	-1.0	-0.1
Number of full brothers	0.9	1.2	5.0	-0.8	-2.2	0.4	-0.0	0.3
Worry too long after embarrassment	0.5	0.9	2.3	0.3	1.5	-0.3	-1.1	-0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.4	0.2	-0.9	-0.4	-1.2	0.2
Wheeze or whistling in the chest in last year	2.4	4.4	7.1	2.5	-1.4	-2.7	-1.1	-2.4
Number of children fathered	1.1	1.2	2.3	1.3	-0.1	-1.5	-0.9	-1.1
Reason for reducing amount of alcohol drunk: Health precaution	1.5	1.8	2.7	1.3	1.7	-1.4	-0.6	-1.4
Age at first live birth	0.4	0.7	3.3	-0.2	1.8	0.3	-0.4	-0.3
Pulse wave peak to peak time	0.6	0.8	3.0	0.5	0.3	-0.1	1.7	-0.6
Health satisfaction	1.0	1.4	2.0	1.2	-1.2	-1.4	-0.2	-1.4
Shortness of breath walking on level ground	0.2	0.3	0.6	-0.8	0.5	0.5	-0.1	0.4
Qualifications: College or University degree	0.2	0.6	1.3	-1.1	0.1	1.2	0.5	0.4
Eye problems/disorders: None of the above	1.3	1.5	6.3	-0.4	-0.6	0.6	2.5	0.3
Mouth/teeth dental problems: Loose teeth	0.0	0.1	0.2	-0.0	0.4	0.1	0.0	0.3
Emphysema/chronic bronchitis	0.3	0.4	1.6	0.2	-0.2	0.4	-0.3	1.2
Medication for pain relief, constipation, heartburn	2.6	4.4	7.3	-2.1	1.7	2.1	2.7	1.6
Neck or shoulder pain in last month	1.3	1.8	3.4	1.8	-0.6	-1.5	-1.2	-1.3
Medication: Blood pressure	2.0	3.6	11.0	1.6	1.3	-1.4	-3.3	-0.9
Angina (self-reported)	0.7	0.9	3.6	0.6	-1.9	-0.5	-0.1	0.4
Migraine (self-reported)	1.1	1.4	2.6	1.6	-0.6	-1.2	-0.7	-1.4
Medication: Ibuprofen	0.4	0.5	1.1	0.3	-1.0	-0.7	-0.4	-0.9
Medication: Allopurinol	0.4	0.5	2.0	-0.0	-1.4	-0.2	0.5	0.1
Medication: Omeprazole	0.8	1.0	2.1	0.9	0.1	-1.2	-0.6	-1.4
Medication: Seretide 50 evohaler	1.0	1.1	3.8	0.6	-1.9	-0.8	0.8	-0.2
Mean time to correctly identify matches	1.5	2.9	5.3	-1.9	-0.6	1.9	1.3	2.3
Heart disease (mother)	0.1	0.1	0.1	-0.4	0.4	0.4	-0.1	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	0.9	-0.9	-0.7	0.6	0.6	0.6
Whole body fat mass	8.5	35.5	55.2	7.3	-4.0	-7.4	-3.7	-6.3
Leg fat mass (right)	6.8	26.5	39.5	6.2	-4.2	-6.3	-2.8	-5.3
Arm predicted mass (right)	1.4	7.0	11.2	3.2	-1.4	-3.3	-1.4	-3.1
Pulse rate, automated reading	0.8	2.7	9.7	0.7	-3.1	-0.9	-1.6	-0.2
Alcohol intake frequency.	0.7	1.6	2.8	1.4	-0.7	-1.7	-1.2	-1.2
Comparative height size at age 10	2.0	10.9	19.3	4.1	2.1	-4.4	-1.3	-3.5
Number of full sisters	0.5	0.6	1.3	0.6	-1.2	-0.6	-0.6	-0.5
Suffer from ‘nerves’	0.7	1.1	3.7	0.5	-0.1	-1.0	-1.9	-0.8
Overall health rating	0.6	1.3	2.8	1.6	-0.4	-1.7	-0.5	-0.7
Chest pain or discomfort	0.1	0.1	0.4	0.1	0.6	0.1	-0.2	0.5
Had major operations	1.7	2.0	6.1	-0.6	-2.5	0.4	-1.8	0.6
Age at last live birth	0.3	0.4	1.0	-0.4	1.0	0.9	-0.2	0.5
Family relationship satisfaction	0.1	0.2	0.5	0.2	-0.7	-0.0	0.5	-0.1
Leg pain on walking	0.7	0.8	1.5	1.0	-0.4	-1.1	-1.2	-0.6
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.2	0.4	-0.2	-0.3	0.0	-0.5	0.6
Commuting to job workplace: Car/motor vehicle	0.4	0.4	1.0	1.0	0.2	-0.8	0.1	-0.8
Illness, injury, bereavement, stress in last 2 years	0.6	0.8	2.0	0.1	1.4	0.1	1.2	0.8
Medication: Aspirin	0.9	1.3	5.2	0.1	-0.5	-0.2	-2.3	0.9
Supplements: Vitamin C	0.2	0.3	1.2	0.1	-1.1	-0.0	0.1	0.2
Knee pain experienced in last month	0.6	1.0	3.2	0.1	-1.8	0.2	1.3	-0.1
Hypertension (Self-reported)	1.7	4.8	9.1	2.2	0.2	-2.5	-3.0	-1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	1.1	0.6	-1.1	0.0	0.6	-0.2
Illnesses of father: Heart disease	0.2	0.3	0.7	0.1	-0.8	-0.2	-0.6	-0.5
Illnesses of siblings: Diabetes	1.9	2.3	4.1	1.7	-2.0	-1.7	-1.2	-0.3
Smoking status: Previous	1.0	1.5	6.0	0.3	-2.4	-0.3	-1.0	0.6
Forced expiratory volume in 1-second (FEV1), predicted	5.0	10.5	17.9	3.9	1.0	-4.0	-1.5	-4.2
Whole body fat-free mass	1.4	7.8	12.7	3.5	-1.2	-3.6	-1.7	-3.1
Leg fat-free mass (right)	2.5	13.3	20.8	4.4	-0.9	-4.6	-2.8	-4.3
Arm fat percentage (left)	7.1	28.3	42.0	6.5	-4.2	-6.5	-3.4	-5.3
Average weekly red wine intake	1.9	2.7	7.4	1.2	1.3	-1.4	-2.7	-1.1
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.9	1.4	0.5	-1.0	-0.3	-0.4
Mood swings	1.1	2.0	7.6	0.6	-2.8	-0.9	-1.1	0.1
Loneliness, isolation	1.3	1.8	3.6	1.5	-1.9	-1.4	-1.1	-0.5
Long-standing illness, disability or infirmity	0.7	1.1	5.0	0.2	-2.2	-0.3	-0.4	0.6
Ever had bowel cancer screening	0.7	0.9	1.3	1.1	-0.7	-1.2	0.4	-1.1
Diabetes diagnosed by doctor	0.1	0.2	0.5	0.4	-0.7	-0.7	-0.1	0.1
Ever had stillbirth, spontaneous miscarriage or termination	1.2	1.3	2.1	1.4	-0.8	-1.1	-0.7	-1.4
Friendships satisfaction	0.3	0.4	0.5	-0.6	0.6	0.5	-0.7	0.7
Qualifications: nursing, teaching	0.5	0.8	2.7	-0.7	-0.3	0.8	1.6	0.4
Commuting to job workplace: Walk	1.2	1.3	2.3	-1.5	0.3	1.4	0.1	1.5
Eye problems/disorders: Cataract	0.7	0.8	1.7	0.6	0.2	-1.0	-1.3	-0.9
Mouth/teeth dental problems: Mouth ulcers	1.9	3.1	6.1	-2.0	-0.0	2.1	1.1	2.5
Medication for cholesterol	0.8	1.3	4.4	-0.3	-0.9	0.9	2.1	-0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	3.7	4.4	7.7	2.8	0.1	-2.4	-1.4	-2.6
Back pain experienced in last month	2.9	4.2	6.1	2.3	1.0	-2.5	-1.8	-2.4
Mineral and other dietary supplements	0.6	0.8	1.5	-1.0	0.3	1.2	1.0	0.8
Breast cancer (self-reported)	1.1	1.3	2.4	1.0	-1.5	-1.1	-1.4	-0.4
Asthma (self-reported)	0.5	1.0	2.2	1.1	-1.0	-1.5	0.4	-0.8
Osteoporosis (self-reported)	0.9	1.2	5.3	-0.4	-0.3	0.3	2.3	-0.3
Osteoarthritis (self-reported)	1.9	2.4	3.4	-1.8	-1.0	1.8	1.5	1.6
Medication: Aspirin	0.9	1.1	4.6	0.3	-0.8	-0.3	-2.1	0.6
Medication: Gliclazide	1.0	1.1	1.8	-1.3	0.0	1.2	1.1	1.0
Illnesses of father: None of the above (group 1)	1.2	1.4	3.1	-1.0	0.3	1.3	1.8	1.1
Smoking status: Current	0.3	0.5	2.5	0.2	-1.6	-0.4	0.1	-0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.6	3.3	5.4	-2.3	1.8	2.1	0.2	1.9
Whole body water mass	1.3	7.5	12.1	3.4	-1.4	-3.5	-1.7	-3.0
Leg predicted mass (right)	2.4	13.0	20.1	4.3	-1.0	-4.5	-2.7	-4.3
Arm fat mass (left)	6.9	28.3	43.1	6.4	-4.1	-6.6	-3.3	-5.4
Number of self-reported non-cancer illnesses	0.9	1.6	2.4	1.1	-1.4	-1.5	-1.5	-0.2
Average weekly champagne plus white wine intake	0.5	0.7	1.9	0.8	0.2	-0.8	0.1	-1.4
Miserableness	1.0	1.8	5.7	1.1	-2.4	-0.7	1.3	-0.1
Guilty feelings	0.6	0.9	1.3	0.9	0.8	-0.9	-0.9	-1.1
Wears glasses or contact lenses	0.4	0.4	0.7	-0.7	0.6	0.8	0.5	0.7
Ever taken oral contraceptive pill	0.7	0.8	2.4	-0.6	-1.5	0.7	-0.5	0.5
Hearing aid user	0.8	0.9	1.8	1.0	-0.5	-0.7	-0.9	-1.4
Mother’s age at death	2.3	2.9	4.5	-2.1	0.4	1.9	1.7	1.7
Financial situation satisfaction	1.6	2.0	4.2	1.2	-1.5	-1.4	-0.6	-2.1
Tinnitus: Yes, now most or all of the time	4.1	4.8	7.1	-2.6	0.1	2.7	1.9	2.6
Commuting to job workplace: Public transport	0.2	0.3	0.7	0.2	-0.7	-0.1	-0.8	-0.1
Eye problems/disorders: Glaucoma	1.0	1.2	3.4	0.6	1.3	-0.4	-1.8	-0.3
Medication: Blood pressure	0.3	0.6	1.6	0.7	0.2	-1.0	-1.3	-0.0
Pain type(s) experienced in last month: Hip pain	0.2	0.3	1.2	-0.0	-0.2	0.0	-1.1	0.4
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.0	0.7	-1.0	-0.8	-0.4	-0.4
High cholesterol (Self-reported)	1.5	2.7	4.8	-1.8	0.9	1.6	-1.4	2.2
Medication: Bendroflumethiazide	0.1	0.1	0.3	0.4	-0.3	-0.3	0.6	0.1
Medication: Paracetamol	1.6	2.5	3.8	1.6	-1.8	-1.5	-0.9	-2.0
Medication: Lisinopril	2.1	2.7	4.3	2.1	-0.7	-2.0	-1.6	-1.5
Medication: Atorvastatin	1.6	2.0	2.4	-1.5	-1.3	1.3	-1.4	1.5
Illnesses of father: High blood pressure	3.5	4.4	7.1	2.1	0.3	-2.7	-2.0	-2.5
Alcohol drinker status: Never	1.1	1.4	3.8	-0.2	-2.0	0.2	1.6	0.5
Ever smoked	0.8	1.4	4.6	0.0	-2.1	-0.4	-1.3	0.9
Basal metabolic rate	2.3	12.6	20.4	4.4	-1.7	-4.5	-2.2	-3.9
Leg fat percentage (left)	6.6	23.7	34.9	5.8	-4.6	-5.9	-2.4	-4.9
Arm fat-free mass (left)	1.5	7.7	12.7	3.4	-2.0	-3.6	-1.4	-2.9
Number of operations (self-reported)	0.9	1.3	4.6	-0.5	-2.1	0.3	-0.7	1.0
Average weekly beer plus cider intake	0.2	0.3	1.2	0.1	-1.1	0.2	0.5	0.4
Irritability	1.0	1.7	6.0	0.3	-2.4	-0.7	-1.4	-0.2
Risk taking	2.1	3.1	6.9	1.5	-2.6	-1.7	0.2	-1.8
Ever had prostate specific antigen (PSA) test	0.5	0.5	1.0	1.0	-0.5	-0.5	0.5	1.0
Fractured/broken bones in last 5 years	1.7	2.2	4.2	0.8	-2.0	-1.1	-1.6	-1.6
Age started oral contraceptive pill	1.8	2.2	4.2	-1.3	0.0	1.4	2.0	1.8
Diastolic blood pressure, automated reading	3.1	9.6	17.4	4.2	-1.0	-4.0	-0.4	-3.7
Ever depressed for a whole week	0.6	0.7	3.2	-0.2	-1.8	-0.2	0.0	-0.5
Unable to work because of sickness or disability	0.5	0.6	2.2	0.5	-1.5	-0.5	0.6	-0.2
Commuting to job workplace: Cycle	0.7	0.8	3.3	-0.3	0.7	0.5	1.8	0.1
Myopia	0.8	1.2	1.8	-1.0	1.3	1.1	1.2	0.9
Vascular/heart problems diagnosed by doctor	1.8	4.8	8.2	-2.4	0.3	2.7	2.9	1.6
Cholesterol lowering medication	0.2	0.3	0.9	-0.3	0.4	-0.3	-1.0	0.5
Medication: Omeprazole (e.g. Zanprol)	2.2	2.7	4.5	1.5	0.3	-1.8	-1.8	-2.1
Pain experienced in last month	1.9	3.2	5.8	-2.4	1.3	2.2	1.3	1.4
Supplements: Calcium	1.6	1.8	3.4	1.9	0.8	-1.8	-0.7	-1.1
Basal cell carcinoma (self-reported)	0.8	1.0	4.0	-0.8	-2.0	0.4	0.2	0.2
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.3	0.5	-1.2	-0.1	-0.1	0.3
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	2.2	1.5	-0.4	-1.4	-0.1	-0.4
Heart disease (siblings)	0.5	0.7	2.9	0.5	-1.7	-0.2	0.0	0.1
Alcohol drinker status: Previous	0.8	0.9	1.5	1.1	-0.3	-1.2	-1.0	-0.8
Pack years of smoking	0.2	0.3	0.6	-0.6	0.5	0.5	0.8	0.3
Impedance of whole body	0.7	3.3	4.3	2.0	2.1	-2.1	-0.9	-1.8
Leg fat mass (left)	6.9	27.1	41.0	6.3	-4.1	-6.4	-2.8	-5.5
Arm predicted mass (left)	1.6	7.9	12.9	3.5	-2.0	-3.6	-1.0	-3.1