TWAS hub - PRDM4

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0720	0.0220	7.4e-06	0.081	0.038	0.067	0.046	0.071	4.9e-10	2.0e-05	1.4e-08	2.6e-06	5.0e-09
2	GTEx	Heart Left Ventricle	0.1828	0.0537	1.2e-04	0.046	NA	0.042	NA	0.053	1.8e-03	NA	2.6e-03	NA	8.6e-04
3	GTEx	Whole Blood	0.1040	0.0350	4.2e-04	0.075	NA	0.031	NA	0.051	1.8e-07	NA	6.4e-04	NA	1.8e-05
4	YFS	Blood	0.0519	0.0131	2.3e-12	0.057	0.044	0.058	0.054	0.060	4.7e-18	3.1e-14	1.8e-18	3.6e-17	5.4e-19
5	TCGA	Breast Invasive Carcinoma	0.0115	0.0077	9.5e-03	0.012	0.007	0.001	NA	0.008	1.3e-03	1.2e-02	1.6e-01	NA	6.3e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Trunk fat percentage	9.4	37.8	60.2	7.6	-3.8	-7.8	-3.5	-6.7
Trunk fat mass	9.1	39.1	62.4	7.8	-3.6	-7.9	-3.8	-6.7
Body fat percentage	8.7	34.3	52.9	7.2	-4.3	-7.3	-3.4	-6.1
Whole body fat mass	8.5	35.5	55.2	7.3	-4.0	-7.4	-3.7	-6.3
Ulcerative Colitis	7.1	10.2	18.2	4.3	1.0	-3.9	-2.2	-3.5
Arm fat percentage (left)	7.1	28.3	42.0	6.5	-4.2	-6.5	-3.4	-5.3
Arm fat percentage (right)	7.0	27.5	40.1	6.3	-4.6	-6.3	-3.3	-5.1
Arm fat mass (left)	6.9	28.3	43.1	6.4	-4.1	-6.6	-3.3	-5.4
Leg fat mass (left)	6.9	27.1	41.0	6.3	-4.1	-6.4	-2.8	-5.5
Leg fat mass (right)	6.8	26.5	39.5	6.2	-4.2	-6.3	-2.8	-5.3
Leg fat percentage (left)	6.6	23.7	34.9	5.8	-4.6	-5.9	-2.4	-4.9
Arm fat mass (right)	6.3	25.8	38.9	6.1	-4.2	-6.2	-3.1	-5.1
Leg fat percentage (right)	6.1	22.2	31.3	5.5	-4.9	-5.6	-2.2	-4.5
Weight	5.6	27.5	43.8	6.5	-3.2	-6.6	-3.3	-5.5
Forced expiratory volume in 1-second (FEV1), predicted	5.0	10.5	17.9	3.9	1.0	-4.0	-1.5	-4.2
Ulcerative Colitis (UC)	4.7	8.8	14.5	3.8	2.1	-3.5	-1.7	-3.1
Hip circumference	4.5	19.4	31.2	5.3	-3.3	-5.6	-2.3	-4.6
Falls in the last year	4.5	6.0	10.1	3.2	-2.3	-3.0	-1.0	-2.2
Waist circumference	4.2	15.3	21.3	4.5	-4.1	-4.6	-1.7	-3.9
Vitamin and mineral supplements	4.1	5.6	9.7	-2.8	0.9	3.1	2.1	2.3
Tinnitus: Yes, now most or all of the time	4.1	4.8	7.1	-2.6	0.1	2.7	1.9	2.6
Average weekly fortified wine intake	3.7	4.4	8.1	-2.6	0.7	2.9	1.4	2.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	3.7	4.4	7.7	2.8	0.1	-2.4	-1.4	-2.6
Body mass index (BMI)	3.5	14.9	19.3	4.4	-4.3	-4.4	-2.2	-3.7
Illnesses of father: High blood pressure	3.5	4.4	7.1	2.1	0.3	-2.7	-2.0	-2.5
Multivitamins +/- minerals	3.4	4.3	7.6	2.5	-0.9	-2.7	-1.6	-2.0
Townsend deprivation index at recruitment	3.3	4.6	7.9	-2.3	-0.9	2.8	2.1	2.2
Ovarian Cancer	3.2	4.2	6.2	-2.5	1.0	2.5	1.3	2.5
BMI	3.2	18.4	26.4	4.5	-5.1	-4.5	-2.0	-4.6
Lung cancer (father)	3.2	3.8	6.4	-2.3	1.3	2.5	1.5	1.9
Had other major operations	3.1	3.8	5.0	1.6	-2.2	-2.1	-2.1	-1.6
Illnesses of siblings	3.1	4.4	7.4	-2.7	1.9	2.7	0.3	1.8
Illnesses of mother	3.1	3.8	6.2	-2.1	1.2	2.5	2.0	1.7
Diastolic blood pressure, automated reading	3.1	9.6	17.4	4.2	-1.0	-4.0	-0.4	-3.7
Alzheimer’s Disease (in mother)	2.9	3.4	7.2	-2.5	-0.6	1.6	0.5	2.7
Hair/balding pattern: Pattern 4	2.9	7.1	12.8	-3.5	1.1	3.6	-0.1	3.0
Back pain experienced in last month	2.9	4.2	6.1	2.3	1.0	-2.5	-1.8	-2.4
Schizophrenia vs Biploar Disorder	2.8	3.6	5.6	-1.9	2.2	1.8	1.1	2.4
Medication: Lansoprazole	2.8	3.2	5.2	2.0	-2.3	-1.9	-1.2	-1.3
Leg fat-free mass (left)	2.7	14.1	21.9	4.6	-1.5	-4.7	-2.6	-4.3
Irritable Bowel Disease (IBD)	2.6	6.1	10.5	3.2	1.3	-3.1	-0.4	-2.9
Leg predicted mass (left)	2.6	13.5	20.9	4.5	-1.5	-4.6	-2.5	-4.2
Medication for pain relief, constipation, heartburn	2.6	4.4	7.3	-2.1	1.7	2.1	2.7	1.6
Leg fat-free mass (right)	2.5	13.3	20.8	4.4	-0.9	-4.6	-2.8	-4.3
Wheeze or whistling in the chest in last year	2.4	4.4	7.1	2.5	-1.4	-2.7	-1.1	-2.4
Leg predicted mass (right)	2.4	13.0	20.1	4.3	-1.0	-4.5	-2.7	-4.3
Verbal and Numeric Reasoning (VNR)	2.3	5.6	7.7	-2.7	2.0	2.8	1.8	2.5
Qualifications: O levels/GCSEs or equivalent	2.3	3.7	11.1	0.1	3.3	-0.6	-2.5	-0.8
Mother’s age at death	2.3	2.9	4.5	-2.1	0.4	1.9	1.7	1.7
Basal metabolic rate	2.3	12.6	20.4	4.4	-1.7	-4.5	-2.2	-3.9
Height	2.2	42.3	70.1	8.2	2.7	-8.4	-4.7	-6.7
Diabetes (mother)	2.2	2.8	4.1	1.9	-1.5	-2.0	-1.2	-1.7
Medication: Omeprazole (e.g. Zanprol)	2.2	2.7	4.5	1.5	0.3	-1.8	-1.8	-2.1
Pulse rate	2.1	3.5	7.7	1.1	-2.1	-1.5	-2.8	-1.3
Medication: Lisinopril	2.1	2.7	4.3	2.1	-0.7	-2.0	-1.6	-1.5
Risk taking	2.1	3.1	6.9	1.5	-2.6	-1.7	0.2	-1.8
Major Depression (MDD)	2.0	2.4	3.9	2.0	-1.6	-1.7	-1.1	-1.2
Age when periods started (menarche)	2.0	4.7	8.7	2.5	-0.2	-2.1	2.0	-2.9
Medication: Blood pressure	2.0	3.6	11.0	1.6	1.3	-1.4	-3.3	-0.9
Comparative height size at age 10	2.0	10.9	19.3	4.1	2.1	-4.4	-1.3	-3.5
Intelligence (Savage-Jansen 2018)	1.9	6.0	9.5	-3.0	1.3	3.1	1.5	2.8
Type 2 Diabetes (T2D) (2012)	1.9	2.2	4.0	2.0	-1.6	-1.6	-1.2	-0.5
Neuroticism	1.9	4.5	7.1	2.2	-1.9	-2.7	-2.2	-1.4
Number of treatments/medications taken	1.9	3.4	4.7	1.9	-2.2	-2.1	-2.1	-0.5
Neuroticism score	1.9	4.0	5.6	2.0	-2.1	-2.4	-2.0	-1.4
Illnesses of siblings: Diabetes	1.9	2.3	4.1	1.7	-2.0	-1.7	-1.2	-0.3
Average weekly red wine intake	1.9	2.7	7.4	1.2	1.3	-1.4	-2.7	-1.1
Mouth/teeth dental problems: Mouth ulcers	1.9	3.1	6.1	-2.0	-0.0	2.1	1.1	2.5
Osteoarthritis (self-reported)	1.9	2.4	3.4	-1.8	-1.0	1.8	1.5	1.6
Pain experienced in last month	1.9	3.2	5.8	-2.4	1.3	2.2	1.3	1.4
Age started oral contraceptive pill	1.8	2.2	4.2	-1.3	0.0	1.4	2.0	1.8
Vascular/heart problems diagnosed by doctor	1.8	4.8	8.2	-2.4	0.3	2.7	2.9	1.6
Standing height	1.7	16.9	28.8	5.1	1.7	-5.4	-2.7	-4.4
Had major operations	1.7	2.0	6.1	-0.6	-2.5	0.4	-1.8	0.6
Hypertension (Self-reported)	1.7	4.8	9.1	2.2	0.2	-2.5	-3.0	-1.9
Fractured/broken bones in last 5 years	1.7	2.2	4.2	0.8	-2.0	-1.1	-1.6	-1.6
Taking other prescription medications	1.6	2.5	7.8	1.4	-2.8	-1.5	-0.5	0.4
Serious illness, injury or assault to yourself	1.6	2.0	3.5	1.5	-0.4	-1.7	-1.9	-1.0
High blood pressure	1.6	4.4	7.2	2.3	-0.0	-2.6	-2.7	-1.7
Number of incorrect matches in round	1.6	2.6	5.4	1.3	-2.3	-1.4	-1.8	-1.0
Medication: Ventolin 100micrograms inhaler	1.6	2.1	5.0	1.0	-2.2	-1.4	-1.2	-1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.6	3.3	5.4	-2.3	1.8	2.1	0.2	1.9
Financial situation satisfaction	1.6	2.0	4.2	1.2	-1.5	-1.4	-0.6	-2.1
Medication: Paracetamol	1.6	2.5	3.8	1.6	-1.8	-1.5	-0.9	-2.0
Medication: Atorvastatin	1.6	2.0	2.4	-1.5	-1.3	1.3	-1.4	1.5
Supplements: Calcium	1.6	1.8	3.4	1.9	0.8	-1.8	-0.7	-1.1
Arm predicted mass (left)	1.6	7.9	12.9	3.5	-2.0	-3.6	-1.0	-3.1
Fed-up feelings	1.5	2.7	6.3	2.5	-0.4	-2.1	-1.5	-0.7
Diverticular disease/diverticulitis (self-reported)	1.5	1.8	2.9	1.5	-1.7	-1.2	-1.0	-1.0
Time employed in main current job	1.5	1.7	4.5	0.4	1.9	0.1	2.1	-0.1
Peak expiratory flow (PEF)	1.5	3.5	5.5	1.5	1.6	-1.9	-1.9	-2.3
High blood pressure (siblings)	1.5	2.2	4.1	1.8	-0.5	-2.0	-0.9	-1.6
Reason for reducing amount of alcohol drunk: Health precaution	1.5	1.8	2.7	1.3	1.7	-1.4	-0.6	-1.4
Mean time to correctly identify matches	1.5	2.9	5.3	-1.9	-0.6	1.9	1.3	2.3
High cholesterol (Self-reported)	1.5	2.7	4.8	-1.8	0.9	1.6	-1.4	2.2
Arm fat-free mass (left)	1.5	7.7	12.7	3.4	-2.0	-3.6	-1.4	-2.9
Alcohol usually taken with meals	1.4	2.3	5.2	0.3	2.3	-0.9	-2.1	-0.9
Headache pain in last month	1.4	2.4	5.8	2.4	-0.5	-1.9	-0.3	-1.4
Medication for cholesterol, blood pressure or diabetes	1.4	2.4	4.9	-1.5	-1.6	1.3	2.2	0.5
Forced vital capacity (FVC), Best measure	1.4	5.2	12.3	1.8	3.5	-2.1	-1.8	-1.7
Arm fat-free mass (right)	1.4	7.3	11.4	3.3	-1.5	-3.4	-1.5	-3.2
Arm predicted mass (right)	1.4	7.0	11.2	3.2	-1.4	-3.3	-1.4	-3.1
Whole body fat-free mass	1.4	7.8	12.7	3.5	-1.2	-3.6	-1.7	-3.1
Lupus	1.3	2.0	3.6	1.8	0.5	-1.2	-1.2	-1.9
Rheumatoid Arthritis	1.3	1.8	4.4	0.6	2.1	-0.7	1.4	-1.2
Noisy workplace	1.3	1.6	4.0	1.2	-2.0	-1.0	1.2	0.3
Prospective memory result	1.3	1.5	4.3	1.0	-2.1	-1.2	-0.4	-1.0
Glaucoma (self-reported)	1.3	1.5	5.2	0.2	2.3	-0.2	-1.5	-0.1
Eye problems/disorders: None of the above	1.3	1.5	6.3	-0.4	-0.6	0.6	2.5	0.3
Neck or shoulder pain in last month	1.3	1.8	3.4	1.8	-0.6	-1.5	-1.2	-1.3
Loneliness, isolation	1.3	1.8	3.6	1.5	-1.9	-1.4	-1.1	-0.5
Whole body water mass	1.3	7.5	12.1	3.4	-1.4	-3.5	-1.7	-3.0
Depressed Affect (Nagel 2018)	1.2	2.6	4.5	2.0	-1.7	-2.1	-1.0	-0.6
Alzheimer’s Disease (including proxy)	1.2	1.7	4.0	-2.0	-0.2	1.2	-0.4	1.8
Coronary Artery Disease (CAD)	1.2	1.4	2.8	1.3	-1.2	-1.0	0.6	-1.7
Chronotype (morning person)	1.2	2.8	4.5	1.9	-1.9	-2.1	-0.4	-1.5
Ever used hormone-replacement therapy (HRT)	1.2	1.6	2.8	1.0	-1.7	-1.3	0.5	-1.5
Heel bone mineral density (BMD) T-score, automated (left)	1.2	2.8	8.4	1.3	2.9	-1.5	-0.8	-0.9
Past tobacco smoking	1.2	2.3	9.2	-0.1	3.0	0.2	1.0	-1.0
Hair/balding pattern: Pattern 3	1.2	1.7	3.0	-1.6	0.6	1.5	-0.8	1.7
Length of working week for main job	1.2	1.4	2.4	1.5	0.6	-1.4	0.0	-1.5
Tense / ‘highly strung’	1.2	2.1	6.1	0.2	-2.5	-0.8	-1.9	-0.3
Ever had stillbirth, spontaneous miscarriage or termination	1.2	1.3	2.1	1.4	-0.8	-1.1	-0.7	-1.4
Commuting to job workplace: Walk	1.2	1.3	2.3	-1.5	0.3	1.4	0.1	1.5
Illnesses of father: None of the above (group 1)	1.2	1.4	3.1	-1.0	0.3	1.3	1.8	1.1
Qualifications: CSEs or equivalent	1.1	1.5	1.8	1.3	-1.3	-1.1	-1.0	-1.3
Stomach or abdominal pain in last month	1.1	1.3	2.4	-0.8	-1.6	0.8	1.4	1.0
High blood pressure (mother)	1.1	1.6	2.2	1.4	-0.7	-1.5	-1.0	-1.5
Hearing difficulty/problems with background noise	1.1	1.8	2.7	1.6	0.6	-1.4	-1.6	-1.1
Impedance of arm (left)	1.1	4.9	5.9	2.3	2.4	-2.4	-1.7	-2.1
Exposure to tobacco smoke at home	1.1	1.3	2.5	-1.2	-1.6	0.6	-0.6	1.3
Number of children fathered	1.1	1.2	2.3	1.3	-0.1	-1.5	-0.9	-1.1
Migraine (self-reported)	1.1	1.4	2.6	1.6	-0.6	-1.2	-0.7	-1.4
Mood swings	1.1	2.0	7.6	0.6	-2.8	-0.9	-1.1	0.1
Breast cancer (self-reported)	1.1	1.3	2.4	1.0	-1.5	-1.1	-1.4	-0.4
Alcohol drinker status: Never	1.1	1.4	3.8	-0.2	-2.0	0.2	1.6	0.5
Neuroticism (Nagel 2018)	1.0	2.3	3.4	1.3	-1.4	-1.8	-1.8	-1.0
Crohns Disease (2012)	1.0	1.6	3.3	1.8	-1.1	-1.5	-0.1	-1.1
Medication: Ramipril	1.0	1.3	4.2	-1.1	0.2	1.0	0.4	2.1
Breastfed as a baby	1.0	1.3	2.4	0.7	1.0	-1.1	-1.5	-1.2
Blood clot in the leg (DVT)	1.0	1.3	3.1	1.8	-0.4	-1.7	-0.1	-0.6
Health satisfaction	1.0	1.4	2.0	1.2	-1.2	-1.4	-0.2	-1.4
Medication: Seretide 50 evohaler	1.0	1.1	3.8	0.6	-1.9	-0.8	0.8	-0.2
Smoking status: Previous	1.0	1.5	6.0	0.3	-2.4	-0.3	-1.0	0.6
Medication: Gliclazide	1.0	1.1	1.8	-1.3	0.0	1.2	1.1	1.0
Miserableness	1.0	1.8	5.7	1.1	-2.4	-0.7	1.3	-0.1
Eye problems/disorders: Glaucoma	1.0	1.2	3.4	0.6	1.3	-0.4	-1.8	-0.3
Irritability	1.0	1.7	6.0	0.3	-2.4	-0.7	-1.4	-0.2
Worry (Nagel 2018)	0.9	2.0	3.8	0.6	-1.7	-1.4	-2.0	-0.8
Bipolar Disorder (2011)	0.9	0.9	1.3	-0.9	1.1	1.0	0.3	1.1
Body Mass Index (BMI) (2010)	0.9	1.2	4.5	0.9	-2.1	-0.4	0.8	-0.4
Fluid intelligence score	0.9	1.8	2.4	-1.6	1.2	1.5	1.4	0.9
Medication: Paracetamol	0.9	1.4	2.0	1.4	-0.6	-1.3	-1.0	-1.4
Number of full brothers	0.9	1.2	5.0	-0.8	-2.2	0.4	-0.0	0.3
Medication: Aspirin	0.9	1.3	5.2	0.1	-0.5	-0.2	-2.3	0.9
Osteoporosis (self-reported)	0.9	1.2	5.3	-0.4	-0.3	0.3	2.3	-0.3
Medication: Aspirin	0.9	1.1	4.6	0.3	-0.8	-0.3	-2.1	0.6
Number of self-reported non-cancer illnesses	0.9	1.6	2.4	1.1	-1.4	-1.5	-1.5	-0.2
Number of operations (self-reported)	0.9	1.3	4.6	-0.5	-2.1	0.3	-0.7	1.0
LDL Cholesterol	0.8	1.2	2.6	1.6	-0.6	-1.5	-0.6	-0.9
Smoking Status	0.8	2.0	8.8	0.5	-3.0	-0.5	-0.7	-0.3
Tinnitus: Yes, but not now, but have in the past	0.8	0.9	1.7	-1.3	-1.3	1.0	-0.2	0.4
Medication: Atenolol	0.8	1.0	2.9	0.7	0.8	-0.8	-1.7	-0.6
Hair/balding pattern: Pattern 2	0.8	1.0	1.8	-1.4	0.7	1.0	1.2	0.6
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	3.4	0.4	-1.9	-0.9	0.4	-0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.7	7.3	1.1	2.7	-1.4	-1.4	-0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.3	3.0	0.8	-1.7	-0.6	-1.4	-0.7
Ever highly irritable/argumentative for 2 days	0.8	0.9	3.5	0.3	-1.9	-0.6	-0.9	-0.1
Medication: Amlodipine	0.8	1.1	3.9	0.3	1.0	-0.3	-2.0	-0.6
Medication: Omeprazole	0.8	1.0	2.1	0.9	0.1	-1.2	-0.6	-1.4
Pulse rate, automated reading	0.8	2.7	9.7	0.7	-3.1	-0.9	-1.6	-0.2
Medication for cholesterol	0.8	1.3	4.4	-0.3	-0.9	0.9	2.1	-0.4
Hearing aid user	0.8	0.9	1.8	1.0	-0.5	-0.7	-0.9	-1.4
Ever smoked	0.8	1.4	4.6	0.0	-2.1	-0.4	-1.3	0.9
Myopia	0.8	1.2	1.8	-1.0	1.3	1.1	1.2	0.9
Basal cell carcinoma (self-reported)	0.8	1.0	4.0	-0.8	-2.0	0.4	0.2	0.2
Alcohol drinker status: Previous	0.8	0.9	1.5	1.1	-0.3	-1.2	-1.0	-0.8
Alzheimer’s Disease (in father)	0.7	0.8	3.7	-0.0	0.3	0.0	-1.9	-0.0
HDL Cholesterol	0.7	1.2	3.6	0.7	1.9	-0.8	-1.1	-0.5
Cardiovascular Disease	0.7	2.3	10.0	0.2	-0.5	-1.0	-3.2	-0.4
Lung FVC	0.7	3.7	12.8	-1.0	3.6	0.9	-1.3	1.5
Sensitivity / hurt feelings	0.7	1.1	2.0	1.1	-1.0	-1.1	-0.4	-1.4
Eye problems/disorders: Diabetes related eye disease	0.7	0.7	3.1	-0.1	-0.0	-0.2	-1.8	0.7
Angina	0.7	0.9	3.6	0.6	-1.9	-0.5	-0.3	0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.7	5.6	-0.7	2.4	0.5	-1.2	0.7
Allergy	0.7	1.7	3.3	-1.4	1.1	1.4	0.1	1.8
Impedance of arm (right)	0.7	3.2	4.3	2.0	1.7	-2.1	-1.3	-1.7
Pulse wave Arterial Stiffness index	0.7	0.8	3.7	-0.2	-0.0	-0.2	-1.9	0.4
Pulse wave reflection index	0.7	0.8	2.8	-0.8	1.7	0.6	-0.3	0.6
Angina (self-reported)	0.7	0.9	3.6	0.6	-1.9	-0.5	-0.1	0.4
Alcohol intake frequency.	0.7	1.6	2.8	1.4	-0.7	-1.7	-1.2	-1.2
Suffer from ‘nerves’	0.7	1.1	3.7	0.5	-0.1	-1.0	-1.9	-0.8
Leg pain on walking	0.7	0.8	1.5	1.0	-0.4	-1.1	-1.2	-0.6
Long-standing illness, disability or infirmity	0.7	1.1	5.0	0.2	-2.2	-0.3	-0.4	0.6
Ever had bowel cancer screening	0.7	0.9	1.3	1.1	-0.7	-1.2	0.4	-1.1
Eye problems/disorders: Cataract	0.7	0.8	1.7	0.6	0.2	-1.0	-1.3	-0.9
Ever taken oral contraceptive pill	0.7	0.8	2.4	-0.6	-1.5	0.7	-0.5	0.5
Commuting to job workplace: Cycle	0.7	0.8	3.3	-0.3	0.7	0.5	1.8	0.1
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	2.2	1.5	-0.4	-1.4	-0.1	-0.4
Impedance of whole body	0.7	3.3	4.3	2.0	2.1	-2.1	-0.9	-1.8
Reaction Time	0.6	1.2	2.0	-1.4	-1.0	1.3	0.7	0.9
Blood White Count	0.6	4.5	10.0	-1.9	-1.0	2.4	3.2	1.4
Hypothyroidism (self reported)	0.6	1.4	2.6	1.4	-1.6	-1.3	0.8	0.4
Supplements: Zinc	0.6	0.7	1.4	0.6	-1.1	-0.6	-1.2	-0.2
Medication: Co-codamol	0.6	0.7	1.2	-0.6	-0.8	0.8	0.8	1.1
Forced vital capacity (FVC)	0.6	2.5	9.7	0.2	3.1	-0.7	-1.4	-0.3
Trunk fat-free mass	0.6	3.3	5.8	2.3	-0.8	-2.4	-1.1	-1.9
Forced expiratory volume in 1-second (FEV1)	0.6	2.1	6.3	0.3	2.5	-0.8	-1.7	-0.6
Depression (self-reported)	0.6	0.8	1.0	0.8	-1.0	-1.0	-0.9	-0.5
Trunk predicted mass	0.6	3.3	5.8	2.4	-0.9	-2.4	-1.1	-1.8
Pulse wave peak to peak time	0.6	0.8	3.0	0.5	0.3	-0.1	1.7	-0.6
Overall health rating	0.6	1.3	2.8	1.6	-0.4	-1.7	-0.5	-0.7
Illness, injury, bereavement, stress in last 2 years	0.6	0.8	2.0	0.1	1.4	0.1	1.2	0.8
Knee pain experienced in last month	0.6	1.0	3.2	0.1	-1.8	0.2	1.3	-0.1
Mineral and other dietary supplements	0.6	0.8	1.5	-1.0	0.3	1.2	1.0	0.8
Guilty feelings	0.6	0.9	1.3	0.9	0.8	-0.9	-0.9	-1.1
Ever depressed for a whole week	0.6	0.7	3.2	-0.2	-1.8	-0.2	0.0	-0.5
Crohns Disease (2017)	0.5	1.1	1.9	1.1	0.3	-1.1	1.0	-1.4
Age at First Birth	0.5	0.7	1.5	-0.5	-1.2	0.7	0.7	0.9
Neuroticism (2016)	0.5	0.7	1.7	0.8	-1.3	-0.8	-0.5	-0.6
Primary Biliary Cirrhosis	0.5	0.8	1.1	0.7	-1.0	-0.8	0.8	-1.1
Frequency of depressed mood in last 2 weeks	0.5	0.7	1.9	-0.6	-0.3	0.7	-0.6	1.4
Systolic blood pressure, automated reading	0.5	1.4	3.2	1.8	-0.5	-1.6	0.2	-1.1
Supplements: Glucosamine	0.5	0.7	1.7	0.9	-0.3	-0.8	-0.0	-1.3
Father’s age at death	0.5	0.7	2.3	-0.7	-0.4	0.4	1.5	0.4
Worrier / anxious feelings	0.5	0.9	1.6	0.3	-1.3	-0.9	-0.8	-1.1
Qualifications: A levels/AS levels or equivalent	0.5	1.0	3.0	-1.1	1.7	0.9	-0.0	0.2
Worry too long after embarrassment	0.5	0.9	2.3	0.3	1.5	-0.3	-1.1	-0.8
Number of full sisters	0.5	0.6	1.3	0.6	-1.2	-0.6	-0.6	-0.5
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.9	1.4	0.5	-1.0	-0.3	-0.4
Qualifications: nursing, teaching	0.5	0.8	2.7	-0.7	-0.3	0.8	1.6	0.4
Asthma (self-reported)	0.5	1.0	2.2	1.1	-1.0	-1.5	0.4	-0.8
Average weekly champagne plus white wine intake	0.5	0.7	1.9	0.8	0.2	-0.8	0.1	-1.4
Ever had prostate specific antigen (PSA) test	0.5	0.5	1.0	1.0	-0.5	-0.5	0.5	1.0
Unable to work because of sickness or disability	0.5	0.6	2.2	0.5	-1.5	-0.5	0.6	-0.2
Heart disease (siblings)	0.5	0.7	2.9	0.5	-1.7	-0.2	0.0	0.1
Bipolar Disorder (2018)	0.4	0.6	2.3	0.1	-1.5	-0.0	0.9	-0.4
Schizophrenia (2018)	0.4	0.8	2.2	-0.8	1.5	0.3	-0.8	0.8
Schizophrenia (2014)	0.4	0.9	2.9	-0.6	1.7	0.3	-0.9	0.7
Respiratory disease	0.4	0.9	1.3	1.1	-0.4	-1.2	1.0	-1.0
Lung FEV1/FVC ratio	0.4	2.2	3.5	-1.6	-1.6	1.4	0.3	1.9
Hair Pigment	0.4	10.9	14.9	3.9	-2.6	-3.9	-2.0	-3.7
Average weekly spirits intake	0.4	0.5	0.6	0.7	-0.8	-0.8	-0.6	-0.7
Hand grip strength (right)	0.4	1.0	2.6	0.4	1.6	-0.9	-0.9	-0.8
Maternal smoking around birth	0.4	0.5	1.8	0.5	-0.5	-0.5	-1.4	0.1
Sitting height	0.4	3.0	4.0	1.6	2.0	-1.8	-1.6	-1.6
Had menopause	0.4	0.5	1.3	-0.4	0.8	0.3	0.6	1.1
Qualifications: None of the above	0.4	0.8	3.2	0.6	-0.6	-0.1	1.8	0.5
Pain all over the body in last month	0.4	0.4	0.7	-0.8	-0.3	0.7	0.0	0.8
Medication: Simvastatin	0.4	0.6	2.6	-0.3	0.4	0.1	-0.4	1.6
Alcohol intake versus 10 years previously	0.4	0.6	1.6	0.2	-0.9	-0.4	-1.3	0.5
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	0.9	-0.7	-0.5	0.9	1.0	0.5
Asthma	0.4	0.7	1.7	0.9	-0.9	-1.3	0.3	-0.6
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	2.0	0.3	-1.4	-0.5	-0.5	-0.3
Medication: Cholesterol lowering	0.4	0.6	1.5	0.0	0.6	0.2	-1.1	1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.4	0.2	-0.9	-0.4	-1.2	0.2
Age at first live birth	0.4	0.7	3.3	-0.2	1.8	0.3	-0.4	-0.3
Medication: Ibuprofen	0.4	0.5	1.1	0.3	-1.0	-0.7	-0.4	-0.9
Medication: Allopurinol	0.4	0.5	2.0	-0.0	-1.4	-0.2	0.5	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	0.9	-0.9	-0.7	0.6	0.6	0.6
Commuting to job workplace: Car/motor vehicle	0.4	0.4	1.0	1.0	0.2	-0.8	0.1	-0.8
Wears glasses or contact lenses	0.4	0.4	0.7	-0.7	0.6	0.8	0.5	0.7
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.0	0.7	-1.0	-0.8	-0.4	-0.4
Fasting Glucose	0.3	0.3	1.7	-0.1	0.1	-0.0	1.3	-0.1
Hand grip strength (left)	0.3	0.9	2.0	0.7	1.4	-1.0	-0.7	-0.7
Relative age of first facial hair	0.3	0.6	1.0	0.7	-1.0	-0.6	0.3	-1.0
Ever had hysterectomy (womb removed)	0.3	0.4	1.1	-0.3	-0.8	-0.2	-1.1	0.1
Relative age voice broke	0.3	0.4	0.7	0.3	-0.8	-0.5	-0.8	-0.8
Financial difficulties in last 2 years	0.3	0.4	1.3	-0.6	-1.1	0.7	-0.1	0.0
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	0.7	-0.8	-0.8	0.7	0.2	0.1
Mouth/teeth dental problems: Dentures	0.3	0.5	1.0	0.8	0.2	-0.5	1.0	-0.7
Loud music exposure frequency	0.3	0.3	1.2	-0.3	-0.4	0.1	-1.1	0.0
Gout (self-reported)	0.3	0.4	1.8	0.1	-0.6	-0.2	1.3	0.0
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	1.8	0.4	-0.4	-0.5	0.7	1.4
Birth weight	0.3	0.6	1.3	0.9	1.1	-0.8	-0.6	-0.4
Exposure to tobacco smoke outside home	0.3	0.3	1.5	0.1	-1.2	-0.2	0.3	-0.3
Emphysema/chronic bronchitis	0.3	0.4	1.6	0.2	-0.2	0.4	-0.3	1.2
Age at last live birth	0.3	0.4	1.0	-0.4	1.0	0.9	-0.2	0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	1.1	0.6	-1.1	0.0	0.6	-0.2
Friendships satisfaction	0.3	0.4	0.5	-0.6	0.6	0.5	-0.7	0.7
Smoking status: Current	0.3	0.5	2.5	0.2	-1.6	-0.4	0.1	-0.1
Medication: Blood pressure	0.3	0.6	1.6	0.7	0.2	-1.0	-1.3	-0.0
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.3	0.5	-1.2	-0.1	-0.1	0.3
Depression (Nagel 2018)	0.2	0.3	0.5	0.5	0.7	0.0	-0.0	0.7
Mean Putamen Volume	0.2	0.3	1.0	-0.3	-0.3	0.4	1.0	0.2
HbA1C	0.2	0.2	0.5	-0.2	0.7	0.3	-0.3	0.3
Heel T-Score	0.2	1.5	4.3	-0.5	2.1	0.1	-1.6	-0.6
Systolic Blood Pressure	0.2	1.0	2.3	1.0	-0.3	-1.2	-0.1	-1.5
Type 2 Diabetes (T2D) (2018)	0.2	0.5	1.3	0.4	-1.1	-0.8	0.3	-0.3
Tanning	0.2	2.0	2.8	1.4	-1.7	-1.5	-1.3	-1.0
Hearing difficulty/problems: Yes	0.2	0.3	1.1	0.3	-1.0	0.1	0.1	-0.5
Medication for hormone replacement therapy	0.2	0.3	1.1	-0.2	1.1	-0.0	0.3	0.3
Medication: Metformin	0.2	0.2	0.6	-0.1	0.5	-0.3	-0.8	0.2
Diabetes (father)	0.2	0.3	0.6	0.7	0.6	-0.8	-0.2	-0.3
Current tobacco smoking	0.2	0.4	1.4	0.3	-1.2	-0.5	0.2	-0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.7	0.8	0.8	-0.3	-0.2	-0.1
Hayfever, allergic rhinitis or eczema	0.2	0.4	1.2	0.3	-0.8	-0.5	-0.1	-1.1
Medication: Levothyroxine sodium	0.2	0.3	1.4	-0.2	0.4	0.2	0.3	1.2
Chronic bronchitis/emphysema (father)	0.2	0.3	0.8	0.3	-0.5	-0.0	-0.9	-0.3
Impedance of leg (left)	0.2	1.2	1.7	1.2	1.1	-1.3	0.4	-1.1
Nervous feelings	0.2	0.4	0.8	-0.6	-0.9	0.2	-0.5	0.8
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.2	0.5	-0.5	-0.5	0.3	-0.7	0.4
Heart attack	0.2	0.3	1.1	0.6	-1.0	-0.2	-0.2	0.3
Diabetes (self-reported)	0.2	0.3	0.6	0.4	-0.7	-0.8	-0.2	0.0
Number of live births	0.2	0.3	1.3	-0.0	0.1	-0.2	-1.1	-0.2
Happiness	0.2	0.3	0.6	0.3	-0.7	-0.3	-0.8	0.4
Birth weight of first child	0.2	0.3	0.8	-0.7	0.9	0.3	0.4	-0.3
Shortness of breath walking on level ground	0.2	0.3	0.6	-0.8	0.5	0.5	-0.1	0.4
Qualifications: College or University degree	0.2	0.6	1.3	-1.1	0.1	1.2	0.5	0.4
Supplements: Vitamin C	0.2	0.3	1.2	0.1	-1.1	-0.0	0.1	0.2
Illnesses of father: Heart disease	0.2	0.3	0.7	0.1	-0.8	-0.2	-0.6	-0.5
Commuting to job workplace: Public transport	0.2	0.3	0.7	0.2	-0.7	-0.1	-0.8	-0.1
Pain type(s) experienced in last month: Hip pain	0.2	0.3	1.2	-0.0	-0.2	0.0	-1.1	0.4
Average weekly beer plus cider intake	0.2	0.3	1.2	0.1	-1.1	0.2	0.5	0.4
Cholesterol lowering medication	0.2	0.3	0.9	-0.3	0.4	-0.3	-1.0	0.5
Pack years of smoking	0.2	0.3	0.6	-0.6	0.5	0.5	0.8	0.3
Triglycerides	0.1	0.1	0.3	-0.3	0.3	0.5	0.2	0.5
Blood Red Count	0.1	0.5	1.9	-0.4	-1.4	0.4	0.4	-0.3
Waist Hip Ratio (WHR)	0.1	0.3	1.1	-0.4	-1.0	0.4	-0.1	-0.2
Allergy or Eczema	0.1	0.3	0.8	0.1	-0.7	-0.3	0.5	-0.9
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.2	0.4	0.1	-0.4	0.3	-0.3
Severe depression (siblings)	0.1	0.1	0.2	-0.0	-0.4	-0.1	0.0	0.4
Pack years adult smoking proportion	0.1	0.2	0.4	-0.6	0.3	0.5	0.6	0.0
Impedance of leg (right)	0.1	0.4	0.7	0.8	0.5	-0.7	0.8	-0.4
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.1	-0.3	-0.3	-0.0	0.4	0.4
Mouth/teeth dental problems	0.1	0.2	1.0	-0.2	0.0	-0.1	-1.0	0.1
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.4	-0.2	-0.4	0.4	-0.4	0.6
Mouth/teeth dental problems: Bleeding gums	0.1	0.2	0.4	-0.5	0.3	0.4	-0.6	0.3
Chronic bronchitis/emphysema (mother)	0.1	0.2	0.7	-0.1	-0.8	0.1	-0.1	0.2
Comparative body size at age 10	0.1	0.2	1.0	-0.2	0.1	0.2	-1.0	-0.1
Heart disease (mother)	0.1	0.1	0.1	-0.4	0.4	0.4	-0.1	0.1
Chest pain or discomfort	0.1	0.1	0.4	0.1	0.6	0.1	-0.2	0.5
Family relationship satisfaction	0.1	0.2	0.5	0.2	-0.7	-0.0	0.5	-0.1
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.2	0.4	-0.2	-0.3	0.0	-0.5	0.6
Diabetes diagnosed by doctor	0.1	0.2	0.5	0.4	-0.7	-0.7	-0.1	0.1
Medication: Bendroflumethiazide	0.1	0.1	0.3	0.4	-0.3	-0.3	0.6	0.1
Bipolar Disorder or Schizophrenia	0.0	0.1	0.3	-0.5	0.2	0.2	-0.1	0.4
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Blood Eosinophil Count	0.0	0.2	0.5	0.0	-0.7	0.0	0.7	0.1
Blood Platelet Count	0.0	0.2	0.8	-0.2	-0.9	0.2	-0.1	-0.4
Mouth/teeth dental problems: Loose teeth	0.0	0.1	0.2	-0.0	0.4	0.1	0.0	0.3

Hub : Genes

PRDM4

Models

Trait associations