[Hub]/) : Traits : Leg fat mass (left) :

chr11:42,881,882-44,607,471

Best TWAS P=3.54e-20 · Best GWAS P=1.46e-19 conditioned to 0.0184

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex HSD17B12 0.44 0.51 lasso 11 0.53 6.0e-76 8.4 -8.3 8.2e-17 -0.82 0.51 0.49 FALSE
2 GTEx Adipose Subcutaneous HSD17B12 0.31 0.35 lasso 5 0.37 2.8e-31 8.4 -8.5 1.7e-17 -0.83 0.50 0.50 FALSE
3 GTEx Adipose Subcutaneous RP11-613D13.5 0.10 0.11 lasso 2 0.10 8.1e-09 8.4 -8.5 1.5e-17 -0.82 0.34 0.66 FALSE
4 GTEx Adipose Visceral Omentum HSD17B12 0.28 0.25 enet 17 0.21 2.6e-11 8.4 -8.6 1.0e-17 -0.84 0.40 0.60 FALSE
5 GTEx Adipose Visceral Omentum SEC14L1P1 0.12 0.00 enet 6 0.00 3.5e-01 4.1 6.5 5.9e-11 0.50 0.05 0.48 FALSE
6 GTEx Adipose Visceral Omentum RP11-613D13.5 0.18 0.01 lasso 3 0.05 8.9e-04 8.4 -7.6 3.5e-14 -0.67 0.10 0.88 FALSE
7 GTEx Adrenal Gland HSD17B12 0.20 0.19 lasso 7 0.18 5.2e-07 8.4 -8.5 2.7e-17 -0.81 0.41 0.56 FALSE
8 GTEx Artery Aorta HSD17B12 0.61 0.55 lasso 9 0.59 3.4e-39 8.4 -8.1 4.4e-16 -0.81 0.48 0.52 FALSE
9 GTEx Artery Aorta RP11-613D13.5 0.31 0.27 lasso 3 0.27 3.0e-15 8.4 -8.3 6.9e-17 -0.83 0.48 0.52 FALSE
10 GTEx Artery Coronary HSD17B12 0.61 0.41 lasso 19 0.43 4.5e-16 8.4 -8.4 4.4e-17 -0.81 0.45 0.55 FALSE
11 GTEx Artery Tibial HSD17B12 0.47 0.54 lasso 5 0.59 8.9e-57 8.4 -8.4 4.7e-17 -0.82 0.49 0.51 FALSE
12 GTEx Artery Tibial RP11-613D13.5 0.17 0.18 lasso 6 0.18 2.4e-14 8.4 -8.7 2.8e-18 -0.84 0.44 0.56 FALSE
13 GTEx Brain Caudate basal ganglia HSD17B12 0.68 0.43 lasso 18 0.49 6.0e-16 8.5 -8.1 4.9e-16 -0.81 0.41 0.59 FALSE
14 GTEx Brain Caudate basal ganglia RP11-613D13.5 0.32 0.14 enet 24 0.13 1.6e-04 8.6 -6.5 9.4e-11 -0.84 0.06 0.88 FALSE
15 GTEx Brain Cerebellar Hemisphere HSD17B12 0.50 0.41 enet 33 0.29 3.0e-08 8.5 -7.7 1.4e-14 -0.82 0.37 0.63 FALSE
16 GTEx Brain Cerebellum HSD17B12 0.52 0.39 lasso 16 0.36 2.4e-11 8.5 -8.6 8.9e-18 -0.84 0.45 0.55 FALSE
17 GTEx Brain Cortex HSD17B12 0.52 0.37 lasso 9 0.40 5.4e-12 8.5 -8.5 1.3e-17 -0.83 0.34 0.66 FALSE
18 GTEx Brain Frontal Cortex BA9 HSD17B12 0.45 0.38 lasso 7 0.36 2.8e-10 8.4 -8.6 9.6e-18 -0.83 0.26 0.74 FALSE
19 GTEx Brain Hippocampus HSD17B12 0.49 0.43 lasso 6 0.41 8.9e-11 8.4 -8.6 1.2e-17 -0.82 0.19 0.81 FALSE
20 GTEx Brain Nucleus accumbens basal ganglia HSD17B12 0.41 0.27 lasso 16 0.20 4.5e-06 8.5 -7.8 7.8e-15 -0.73 0.25 0.73 FALSE
21 GTEx Brain Putamen basal ganglia HSD17B12 0.51 0.30 enet 28 0.33 1.3e-08 8.5 -8.1 4.5e-16 -0.79 0.11 0.86 FALSE
22 GTEx Breast Mammary Tissue HSD17B12 0.21 0.17 lasso 1 0.12 6.0e-07 8.4 -8.4 3.5e-17 -0.80 0.36 0.64 FALSE
23 GTEx Breast Mammary Tissue RP11-613D13.5 0.18 0.11 lasso 5 0.15 6.3e-08 8.4 -7.6 2.7e-14 -0.77 0.21 0.76 FALSE
24 GTEx Breast Mammary Tissue (Male) HSD17B12 0.48 0.34 lasso 14 0.34 1.1e-08 8.5 -8.5 1.4e-17 -0.84 0.24 0.74 FALSE
25 GTEx Cells Transformed fibroblasts HSD17B12 0.60 0.69 lasso 10 0.69 2.0e-71 8.4 -8.5 1.6e-17 -0.83 0.49 0.51 FALSE
26 GTEx Cells Transformed fibroblasts RP11-613D13.5 0.34 0.42 lasso 9 0.42 4.5e-34 8.4 -8.4 3.5e-17 -0.83 0.48 0.52 FALSE
27 GTEx Colon Sigmoid HSD17B12 0.44 0.38 lasso 8 0.37 6.7e-14 8.4 -8.5 1.5e-17 -0.83 0.41 0.59 FALSE
28 GTEx Colon Transverse HSD17B12 0.48 0.49 lasso 4 0.50 1.3e-26 8.4 -8.5 2.4e-17 -0.82 0.49 0.51 FALSE
29 GTEx Colon Transverse RP11-613D13.5 0.21 0.24 lasso 3 0.23 3.4e-11 8.4 -8.4 2.9e-17 -0.82 0.48 0.52 FALSE
30 GTEx Esophagus Gastroesophageal Junction HSD17B12 0.51 0.35 lasso 7 0.37 3.1e-14 8.4 -9.2 3.5e-20 -0.85 0.41 0.59 TRUE
31 GTEx Esophagus Mucosa HSD17B12 0.54 0.58 lasso 12 0.58 1.3e-47 8.4 -8.6 9.0e-18 -0.84 0.50 0.50 FALSE
32 GTEx Esophagus Mucosa RP11-613D13.5 0.17 0.19 lasso 6 0.18 2.5e-12 8.5 -8.6 6.1e-18 -0.86 0.34 0.66 FALSE
33 GTEx Esophagus Muscularis HSD17B12 0.57 0.56 lasso 8 0.58 1.1e-42 8.4 -8.3 8.3e-17 -0.81 0.47 0.53 FALSE
34 GTEx Esophagus Muscularis RP11-613D13.5 0.21 0.20 lasso 2 0.19 9.6e-12 8.4 -8.2 1.6e-16 -0.83 0.45 0.55 FALSE
35 GTEx Heart Atrial Appendage HSD17B12 0.52 0.46 lasso 6 0.44 1.2e-21 8.4 -8.0 1.6e-15 -0.81 0.49 0.51 FALSE
36 GTEx Heart Atrial Appendage RP11-613D13.5 0.18 0.02 enet 11 0.07 5.3e-04 8.4 -6.8 1.2e-11 -0.78 0.08 0.90 FALSE
37 GTEx Heart Left Ventricle HSD17B12 0.25 0.28 lasso 4 0.25 8.2e-14 8.4 -8.6 1.3e-17 -0.81 0.48 0.52 FALSE
38 GTEx Liver HSD17B12 0.46 0.38 enet 24 0.28 1.3e-08 8.3 -8.1 6.0e-16 -0.83 0.16 0.84 FALSE
39 GTEx Liver RP11-613D13.5 0.30 0.24 lasso 3 0.23 4.6e-07 9.0 -8.4 4.7e-17 -0.97 0.01 0.99 FALSE
40 GTEx Lung HSD17B12 0.54 0.59 enet 32 0.61 8.3e-59 8.4 -8.0 1.4e-15 -0.80 0.48 0.52 FALSE
41 GTEx Lung RP11-613D13.5 0.18 0.20 lasso 2 0.17 6.0e-13 8.4 -8.4 3.1e-17 -0.81 0.48 0.52 FALSE
42 GTEx Muscle Skeletal HSD17B12 0.35 0.38 enet 24 0.37 3.4e-38 8.4 -8.2 3.1e-16 -0.83 0.48 0.52 FALSE
43 GTEx Nerve Tibial HSD17B12 0.58 0.52 enet 56 0.56 3.5e-47 8.5 -7.5 8.7e-14 -0.80 0.46 0.54 FALSE
44 GTEx Nerve Tibial RP11-613D13.5 0.14 0.19 lasso 2 0.18 1.1e-12 8.5 -8.5 2.2e-17 -0.85 0.43 0.57 FALSE
45 GTEx Ovary HSD17B12 0.45 0.36 lasso 17 0.33 5.4e-09 8.4 -8.7 4.7e-18 -0.82 0.29 0.71 FALSE
46 GTEx Pancreas HSD17B12 0.43 0.40 lasso 2 0.40 7.6e-18 8.4 -8.5 1.7e-17 -0.80 0.48 0.52 FALSE
47 GTEx Prostate HSD17B12 0.65 0.51 enet 34 0.53 8.8e-16 8.5 -7.8 9.2e-15 -0.80 0.43 0.57 FALSE
48 GTEx Prostate RP11-613D13.5 0.29 0.07 enet 27 0.16 8.2e-05 8.5 -6.7 2.4e-11 -0.67 0.21 0.47 FALSE
49 GTEx Skin Not Sun Exposed Suprapubic HSD17B12 0.45 0.59 lasso 1 0.59 1.9e-39 8.4 -8.4 3.5e-17 -0.80 0.52 0.48 FALSE
50 GTEx Skin Not Sun Exposed Suprapubic RP11-613D13.5 0.17 0.12 enet 19 0.15 2.2e-08 8.5 -8.8 1.9e-18 -0.92 0.04 0.96 FALSE
51 GTEx Skin Sun Exposed Lower leg HSD17B12 0.46 0.60 lasso 7 0.61 9.2e-63 8.4 -8.6 6.8e-18 -0.83 0.48 0.52 FALSE
52 GTEx Skin Sun Exposed Lower leg RP11-613D13.5 0.17 0.22 lasso 3 0.21 2.2e-17 8.4 -8.5 1.4e-17 -0.83 0.43 0.57 FALSE
53 GTEx Spleen HSD17B12 0.55 0.48 enet 48 0.47 9.6e-14 8.4 -7.0 2.3e-12 -0.73 0.28 0.72 FALSE
54 GTEx Stomach HSD17B12 0.37 0.51 lasso 2 0.51 9.5e-28 8.4 -8.4 3.8e-17 -0.80 0.46 0.54 FALSE
55 GTEx Stomach RP11-613D13.5 0.18 0.21 lasso 3 0.21 1.6e-10 8.4 -8.4 3.6e-17 -0.80 0.44 0.56 FALSE
56 GTEx Testis HSD17B12 0.67 0.58 lasso 10 0.60 8.5e-33 8.5 -8.6 1.2e-17 -0.86 0.47 0.53 FALSE
57 GTEx Thyroid HSD17B12 0.52 0.59 lasso 4 0.59 1.1e-55 8.4 -8.5 1.8e-17 -0.82 0.51 0.49 FALSE
58 GTEx Thyroid RP11-613D13.5 0.24 0.18 lasso 2 0.15 7.3e-12 8.4 -8.6 9.2e-18 -0.83 0.45 0.55 FALSE
59 GTEx Uterus HSD17B12 0.60 0.48 enet 20 0.52 2.1e-12 8.3 -8.1 8.1e-16 -0.81 0.35 0.64 FALSE
60 GTEx Uterus RP11-613D13.5 0.61 0.22 lasso 12 0.26 3.9e-06 7.0 -8.5 1.8e-17 -0.61 0.23 0.53 FALSE
61 GTEx Vagina HSD17B12 0.55 0.31 lasso 19 0.34 1.3e-08 8.4 -8.1 7.7e-16 -0.75 0.27 0.69 FALSE
62 GTEx Whole Blood HSD17B12 0.29 0.36 lasso 3 0.36 4.5e-34 8.4 -8.5 2.0e-17 -0.82 0.49 0.51 FALSE
63 GTEx Whole Blood RP11-613D13.5 0.06 0.01 lasso 4 0.00 1.2e-01 -5.0 -6.1 8.1e-10 -0.71 0.06 0.32 FALSE
64 METSIM Adipose HSD17B12 0.19 0.29 bslmm 660 0.29 4.7e-43 8.6 -8.3 1.1e-16 -0.82 0.31 0.69 FALSE
65 ROSMAP Brain Pre-frontal Cortex HSD17B12 0.45 0.37 enet 72 0.47 1.1e-68 8.4 -6.8 7.8e-12 -0.72 0.52 0.48 FALSE
66 YFS Blood HSD17B12 0.37 0.44 enet 31 0.47 1.2e-176 8.5 -8.2 2.0e-16 -0.78 0.30 0.70 FALSE
67 The Cancer Genome Atlas Bladder Urothelial Carcinoma HSD17B12 0.19 0.27 enet 10 0.27 6.1e-23 8.4 -8.6 1.2e-17 -0.83 0.37 0.63 FALSE
68 The Cancer Genome Atlas Breast Invasive Carcinoma HSD17B12 0.10 0.20 lasso 4 0.20 7.5e-39 8.4 -8.5 1.7e-17 -0.81 0.48 0.52 FALSE
69 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma HSD17B12 0.18 0.22 lasso 2 0.20 2.2e-10 8.4 -8.8 1.4e-18 -0.79 0.38 0.62 FALSE
70 The Cancer Genome Atlas Colon Adenocarcinoma HSD17B12 0.33 0.36 enet 17 0.39 7.5e-24 8.5 -8.5 2.4e-17 -0.83 0.37 0.63 FALSE
71 The Cancer Genome Atlas Esophageal Carcinoma HSD17B12 0.27 0.31 enet 17 0.31 1.2e-10 8.3 -8.2 2.6e-16 -0.80 0.37 0.63 FALSE
72 The Cancer Genome Atlas Glioblastoma Multiforme HSD17B12 0.43 0.43 lasso 6 0.45 3.4e-15 8.5 -8.6 1.2e-17 -0.83 0.36 0.64 FALSE
73 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma HSD17B12 0.19 0.27 lasso 3 0.27 9.8e-31 8.4 -8.6 9.3e-18 -0.82 0.37 0.63 FALSE
74 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma HSD17B12 0.35 0.52 lasso 4 0.54 4.7e-71 8.5 -8.6 1.2e-17 -0.83 0.39 0.61 FALSE
75 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma HSD17B12 0.19 0.24 lasso 6 0.24 4.7e-14 8.4 -8.6 1.1e-17 -0.83 0.38 0.62 FALSE
76 The Cancer Genome Atlas Brain Lower Grade Glioma HSD17B12 0.32 0.48 lasso 4 0.47 1.5e-60 8.4 -8.5 2.6e-17 -0.81 0.49 0.51 FALSE
77 The Cancer Genome Atlas Liver Hepatocellular Carcinoma HSD17B12 0.22 0.25 lasso 1 0.24 9.8e-12 8.4 -8.4 3.5e-17 -0.80 0.43 0.57 FALSE
78 The Cancer Genome Atlas Lung Adenocarcinoma HSD17B12 0.22 0.33 enet 18 0.33 1.1e-39 8.4 -8.7 5.0e-18 -0.81 0.43 0.57 FALSE
79 The Cancer Genome Atlas Lung Squamous Cell Carcinoma HSD17B12 0.20 0.26 lasso 2 0.26 1.3e-29 8.4 -8.5 2.1e-17 -0.82 0.47 0.53 FALSE
80 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma HSD17B12 0.18 0.23 lasso 4 0.23 6.6e-16 8.3 -8.4 6.4e-17 -0.83 0.40 0.60 FALSE
81 The Cancer Genome Atlas Pancreatic Adenocarcinoma HSD17B12 0.28 0.30 lasso 4 0.29 8.1e-13 8.4 -8.4 3.1e-17 -0.81 0.40 0.60 FALSE
82 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma HSD17B12 0.21 0.24 lasso 8 0.23 1.9e-09 8.4 -8.3 6.8e-17 -0.82 0.11 0.89 FALSE
83 The Cancer Genome Atlas Prostate Adenocarcinoma HSD17B12 0.36 0.52 lasso 6 0.52 3.8e-63 8.4 -8.5 1.3e-17 -0.83 0.47 0.53 FALSE
84 The Cancer Genome Atlas Rectum Adenocarcinoma HSD17B12 0.39 0.25 lasso 4 0.26 7.2e-07 8.3 -8.2 1.8e-16 -0.85 0.20 0.77 FALSE
85 The Cancer Genome Atlas Soft Tissue Sarcoma HSD17B12 0.13 0.20 lasso 3 0.18 3.9e-11 8.4 -8.5 2.7e-17 -0.81 0.44 0.56 FALSE
86 The Cancer Genome Atlas Skin Cutaneous Melanoma HSD17B12 0.15 0.08 enet 17 0.08 3.0e-03 8.5 -8.8 1.6e-18 -0.92 0.03 0.77 FALSE
87 The Cancer Genome Atlas Stomach Adenocarcinoma HSD17B12 0.17 0.27 lasso 1 0.26 6.0e-19 8.4 -8.4 3.5e-17 -0.80 0.47 0.53 FALSE
88 The Cancer Genome Atlas Testicular Germ Cell Tumors HSD17B12 0.34 0.26 blup 115 0.26 1.6e-09 8.4 -6.8 1.4e-11 -0.61 0.40 0.60 FALSE
89 The Cancer Genome Atlas Thyroid Carcinoma HSD17B12 0.60 0.66 lasso 2 0.65 4.5e-84 8.4 -8.5 2.6e-17 -0.81 0.49 0.51 FALSE
90 The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma HSD17B12 0.21 0.20 lasso 1 0.16 4.3e-05 8.4 -8.4 3.5e-17 -0.80 0.16 0.69 FALSE