[Hub]/) : Traits : Leg fat mass (left) : ← →

chr11:46,565,407-48,485,877

Best TWAS P=4.41e-22 · Best GWAS P=6.27e-22 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
71	The Cancer Genome Atlas	Lung Adenocarcinoma	C1QTNF4	0.03	0.02	blup	15	0.02	1.3e-03	9.5	-9.7	4.4e-22	-0.97	0.00	0.97	TRUE
5	GTEx	Artery Aorta	C1QTNF4	0.09	0.10	lasso	1	0.08	3.2e-05	9.5	-9.5	2.2e-21	-1.00	0.00	0.99	FALSE
18	GTEx	Esophagus Mucosa	C1QTNF4	0.10	0.11	lasso	1	0.10	5.0e-07	9.5	-9.5	2.2e-21	-1.00	0.00	1.00	FALSE
23	GTEx	Heart Left Ventricle	C1QTNF4	0.10	0.11	lasso	1	0.09	1.1e-05	9.5	-9.5	2.2e-21	-1.00	0.00	0.99	FALSE
53	The Cancer Genome Atlas	Colon Adenocarcinoma	C1QTNF4	0.12	0.12	lasso	1	0.12	1.6e-07	9.5	-9.5	2.2e-21	-1.00	0.00	1.00	FALSE
15	GTEx	Cells Transformed fibroblasts	NDUFS3	0.08	0.01	lasso	2	0.01	3.3e-02	9.6	-9.3	1.8e-20	-0.98	0.00	0.98	FALSE
27	GTEx	Muscle Skeletal	C1QTNF4	0.09	0.14	lasso	3	0.13	9.9e-13	9.5	-9.2	2.9e-20	-0.98	0.00	1.00	FALSE
57	The Cancer Genome Atlas	Esophageal Carcinoma	C1QTNF4	0.39	0.33	blup	15	0.35	6.1e-12	9.5	-9.2	5.2e-20	-0.98	0.00	1.00	FALSE
4	GTEx	Adipose Subcutaneous	C1QTNF4	0.16	0.22	lasso	4	0.22	2.5e-18	9.6	-9.1	6.4e-20	-0.98	0.00	1.00	FALSE
32	GTEx	Skin Sun Exposed Lower leg	C1QTNF4	0.25	0.22	lasso	12	0.23	4.2e-19	9.5	-9.1	7.1e-20	-0.95	0.00	1.00	FALSE
21	GTEx	Heart Atrial Appendage	C1QTNF4	0.26	0.14	lasso	9	0.17	3.9e-08	9.5	-9.0	1.6e-19	-0.95	0.01	0.99	FALSE
55	The Cancer Genome Atlas	Colon Adenocarcinoma	NUP160	0.05	0.05	blup	44	0.05	7.7e-04	-8.3	9.0	1.6e-19	0.82	0.02	0.84	FALSE
78	The Cancer Genome Atlas	Thyroid Carcinoma	C1QTNF4	0.04	0.01	blup	15	0.03	7.9e-04	9.5	-9.0	3.3e-19	-0.89	0.00	0.95	FALSE
16	GTEx	Colon Transverse	C1QTNF4	0.07	0.02	lasso	6	0.03	2.0e-02	9.6	-8.9	3.6e-19	-0.96	0.01	0.96	FALSE
1	CommonMind	Brain Pre-frontal Cortex	FAM180B	0.07	0.08	lasso	3	0.08	9.1e-10	9.5	8.8	9.6e-19	0.95	0.02	0.98	FALSE
24	GTEx	Liver	C1QTNF4	0.25	0.14	enet	16	0.20	2.3e-06	9.5	-8.8	1.0e-18	-0.84	0.02	0.97	FALSE
11	GTEx	Cells Transformed fibroblasts	FNBP4	0.11	0.05	lasso	8	0.08	1.6e-06	-8.2	8.8	1.2e-18	0.88	0.04	0.96	FALSE
42	ROSMAP	Brain Pre-frontal Cortex	FNBP4	0.04	0.04	lasso	3	0.04	8.2e-06	-8.3	8.7	2.7e-18	0.69	0.95	0.05	FALSE
29	GTEx	Nerve Tibial	C1QTNF4	0.20	0.23	enet	12	0.23	1.7e-16	9.5	-8.7	2.9e-18	-0.96	0.00	1.00	FALSE
20	GTEx	Esophagus Muscularis	C1QTNF4	0.10	0.05	enet	23	0.06	1.4e-04	9.6	-8.7	3.6e-18	-0.93	0.01	0.99	FALSE
33	GTEx	Spleen	C1QTNF4	0.31	0.28	enet	29	0.34	1.8e-09	7.6	-8.7	3.7e-18	-0.89	0.07	0.92	FALSE
31	GTEx	Skin Not Sun Exposed Suprapubic	C1QTNF4	0.32	0.18	enet	33	0.20	5.2e-11	9.5	-8.6	6.4e-18	-0.90	0.00	1.00	FALSE
61	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C1QTNF4	0.12	0.14	enet	4	0.16	6.5e-18	7.6	-8.6	6.8e-18	-0.95	0.03	0.97	FALSE
49	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	C1QTNF4	0.06	0.07	lasso	2	0.06	4.9e-06	7.7	-8.4	3.4e-17	-0.93	0.01	0.99	FALSE
8	GTEx	Brain Cortex	C1QTNF4	0.26	0.04	lasso	8	0.02	1.2e-01	-8.1	-8.4	4.4e-17	-0.80	0.02	0.58	FALSE
35	GTEx	Testis	C1QTNF4	0.14	0.12	lasso	4	0.11	1.6e-05	-8.3	-8.3	7.5e-17	-0.73	0.28	0.67	FALSE
77	The Cancer Genome Atlas	Stomach Adenocarcinoma	C1QTNF4	0.06	0.04	lasso	4	0.03	4.3e-03	7.7	-8.3	1.2e-16	-0.92	0.00	0.92	FALSE
25	GTEx	Lung	C1QTNF4	0.18	0.15	lasso	6	0.13	3.2e-10	7.2	-8.1	5.1e-16	-0.91	0.08	0.92	FALSE
45	YFS	Blood	FNBP4	0.02	0.01	bslmm	301	0.01	8.9e-05	-7.0	8.1	5.9e-16	0.78	0.03	0.95	FALSE
75	The Cancer Genome Atlas	Prostate Adenocarcinoma	NUP160	0.03	0.02	enet	7	0.02	6.3e-03	7.1	8.1	6.1e-16	0.83	0.06	0.38	FALSE
41	ROSMAP	Brain Pre-frontal Cortex	MTCH2	0.35	0.40	enet	9	0.40	4.7e-56	7.6	8.1	6.4e-16	0.91	1.00	0.00	FALSE
26	GTEx	Muscle Skeletal	MTCH2	0.05	0.03	enet	15	0.04	1.5e-04	7.1	7.8	4.8e-15	0.84	0.05	0.94	FALSE
40	NTR	Blood	MTCH2	0.02	0.04	lasso	1	0.04	1.3e-11	7.8	-7.8	6.7e-15	-0.88	0.90	0.10	FALSE
64	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	C1QTNF4	0.13	0.16	lasso	1	0.16	3.1e-09	7.8	-7.8	7.8e-15	-0.88	0.15	0.85	FALSE
66	The Cancer Genome Atlas	Brain Lower Grade Glioma	MADD	0.08	0.01	lasso	5	0.05	3.1e-06	7.2	7.7	1.0e-14	0.62	0.00	0.95	FALSE
14	GTEx	Cells Transformed fibroblasts	C1QTNF4	0.13	0.11	enet	19	0.12	5.2e-09	7.8	-7.7	1.4e-14	-0.84	0.03	0.97	FALSE
58	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	C1QTNF4	0.06	0.08	lasso	3	0.08	7.5e-09	7.6	-7.7	1.5e-14	-0.88	0.04	0.96	FALSE
36	GTEx	Whole Blood	C1QTNF4	0.09	0.05	lasso	3	0.03	1.4e-03	7.6	-7.7	1.9e-14	-0.86	0.18	0.73	FALSE
67	The Cancer Genome Atlas	Brain Lower Grade Glioma	MTCH2	0.11	0.11	lasso	2	0.10	6.4e-12	7.6	7.7	1.9e-14	0.87	0.09	0.91	FALSE
69	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	C1QTNF4	0.19	0.19	lasso	3	0.19	3.2e-09	7.6	-7.7	1.9e-14	-0.87	0.09	0.91	FALSE
19	GTEx	Esophagus Muscularis	MTCH2	0.09	0.04	lasso	6	0.02	1.8e-02	7.8	7.6	2.1e-14	0.78	0.27	0.53	FALSE
10	GTEx	Breast Mammary Tissue (Female)	MADD	0.13	0.04	lasso	3	0.05	1.3e-02	7.3	7.6	2.4e-14	0.81	0.05	0.31	FALSE
70	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	PSMC3	0.09	0.07	blup	39	0.06	8.7e-04	7.2	7.6	3.7e-14	0.85	0.02	0.96	FALSE
51	The Cancer Genome Atlas	Breast Invasive Carcinoma	MADD	0.11	0.03	enet	14	0.06	1.4e-11	-4.6	7.5	6.5e-14	0.56	0.04	0.96	FALSE
37	METSIM	Adipose	C1QTNF4	0.24	0.31	lasso	7	0.31	1.2e-46	7.6	-7.5	9.3e-14	-0.86	1.00	0.00	FALSE
54	The Cancer Genome Atlas	Colon Adenocarcinoma	KBTBD4	0.14	0.01	blup	13	0.02	1.6e-02	-8.2	7.4	1.4e-13	0.90	0.00	0.53	FALSE
65	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	PSMC3	0.07	0.07	enet	7	0.06	1.4e-04	7.3	7.3	2.6e-13	0.82	0.02	0.95	FALSE
34	GTEx	Testis	MTCH2	0.17	0.16	lasso	3	0.16	1.0e-07	7.3	7.3	3.3e-13	0.83	0.52	0.48	FALSE
22	GTEx	Heart Left Ventricle	MADD	0.14	0.01	enet	17	0.05	7.0e-04	-3.1	7.2	4.1e-13	0.70	0.02	0.96	FALSE
9	GTEx	Breast Mammary Tissue	C1QTNF4	0.10	0.06	lasso	2	0.03	8.5e-03	7.3	-7.1	1.6e-12	-0.82	0.10	0.68	FALSE
30	GTEx	Pituitary	MADD	0.42	0.32	lasso	6	0.39	8.9e-11	-4.2	7.0	2.9e-12	0.60	0.25	0.63	FALSE
44	ROSMAP	Brain Pre-frontal Cortex	C1QTNF4	0.05	0.06	blup	281	0.06	1.7e-08	7.2	-6.9	6.7e-12	-0.86	0.09	0.91	FALSE
47	YFS	Blood	PTPMT1	0.03	0.01	lasso	5	0.01	3.2e-04	-8.2	-6.8	9.6e-12	-0.67	0.28	0.61	FALSE
68	The Cancer Genome Atlas	Brain Lower Grade Glioma	PSMC3	0.10	0.05	blup	39	0.08	3.7e-09	7.3	6.8	1.5e-11	0.79	0.04	0.96	FALSE
13	GTEx	Cells Transformed fibroblasts	PSMC3	0.07	0.00	enet	13	0.02	2.3e-02	-2.7	6.7	1.9e-11	0.83	0.03	0.77	FALSE
46	YFS	Blood	PSMC3	0.02	0.01	blup	289	0.01	2.8e-05	9.6	6.7	2.0e-11	0.84	0.00	0.99	FALSE
7	GTEx	Brain Cortex	MTCH2	0.21	0.19	lasso	6	0.16	4.0e-05	7.6	6.6	5.0e-11	0.79	0.35	0.18	FALSE
6	GTEx	Brain Cerebellum	MADD	0.21	0.00	enet	13	0.11	3.3e-04	-3.0	6.5	6.2e-11	0.63	0.07	0.68	FALSE
28	GTEx	Nerve Tibial	NR1H3	0.10	0.00	enet	24	0.08	4.7e-06	-1.5	-6.5	8.3e-11	-0.52	0.01	0.82	FALSE
52	The Cancer Genome Atlas	Breast Invasive Carcinoma	MYBPC3	0.02	0.01	blup	43	0.01	3.4e-03	7.2	-6.5	9.4e-11	-0.74	0.01	0.97	FALSE
17	GTEx	Esophagus Mucosa	MADD	0.27	0.04	enet	18	0.12	4.1e-08	-3.4	6.3	2.3e-10	0.40	0.26	0.08	FALSE
3	GTEx	Adipose Subcutaneous	ACP2	0.08	0.03	enet	18	0.03	3.5e-03	-2.3	6.2	5.4e-10	0.73	0.08	0.78	FALSE
38	METSIM	Adipose	MYBPC3	0.11	0.10	enet	26	0.11	1.0e-15	7.3	-6.2	6.2e-10	-0.81	0.31	0.69	FALSE
50	The Cancer Genome Atlas	Breast Invasive Carcinoma	C1QTNF4	0.02	0.01	lasso	5	0.02	2.1e-04	-2.0	-6.0	1.5e-09	-0.74	0.01	0.83	FALSE
60	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	NUP160	0.08	0.03	blup	42	0.04	6.7e-05	7.6	6.0	2.0e-09	0.71	0.24	0.11	FALSE
62	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MADD	0.20	0.07	enet	9	0.08	2.4e-09	-4.6	6.0	2.3e-09	0.32	0.92	0.01	FALSE
74	The Cancer Genome Atlas	Prostate Adenocarcinoma	MADD	0.15	0.04	enet	10	0.06	4.5e-07	-4.6	5.9	3.1e-09	0.30	0.20	0.03	FALSE
76	The Cancer Genome Atlas	Prostate Adenocarcinoma	PSMC3	0.02	0.02	blup	39	0.02	5.7e-03	7.3	5.9	3.8e-09	0.78	0.02	0.53	FALSE
56	The Cancer Genome Atlas	Colon Adenocarcinoma	PSMC3	0.09	0.05	blup	39	0.05	1.0e-03	-4.4	5.8	6.2e-09	0.55	0.03	0.72	FALSE
39	METSIM	Adipose	PSMC3	0.06	0.03	enet	28	0.04	2.3e-06	3.2	5.8	8.3e-09	0.79	0.03	0.96	FALSE
43	ROSMAP	Brain Pre-frontal Cortex	ACP2	0.03	0.00	blup	295	0.02	1.5e-03	7.2	5.7	9.9e-09	0.72	0.06	0.86	FALSE
79	The Cancer Genome Atlas	Thyroid Carcinoma	MADD	0.07	0.00	enet	11	0.03	6.7e-04	-3.1	5.7	1.2e-08	0.36	0.05	0.13	FALSE
2	CommonMind	Brain Pre-frontal Cortex	MTCH2	0.03	0.00	bslmm	299	0.00	1.1e-01	1.7	5.7	1.3e-08	0.68	0.07	0.53	FALSE
59	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	MYBPC3	0.05	0.03	blup	43	0.04	6.0e-05	5.2	-5.7	1.5e-08	-0.71	0.01	0.98	FALSE
73	The Cancer Genome Atlas	Prostate Adenocarcinoma	AGBL2	0.04	0.03	blup	49	0.03	7.8e-04	-7.0	5.5	4.8e-08	0.41	0.18	0.07	FALSE
48	YFS	Blood	SPI1	0.65	0.18	enet	75	0.27	1.6e-87	7.2	-5.4	5.8e-08	-0.62	1.00	0.00	FALSE
72	The Cancer Genome Atlas	Lung Adenocarcinoma	MYBPC3	0.04	0.02	enet	10	0.04	2.9e-05	7.2	-5.4	5.9e-08	-0.68	0.01	0.98	FALSE
12	GTEx	Cells Transformed fibroblasts	MADD	0.19	0.00	enet	17	0.09	3.3e-07	-3.2	5.3	1.4e-07	0.30	0.53	0.04	FALSE
63	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PSMC3	0.05	0.04	lasso	3	0.05	3.8e-06	3.2	5.3	1.4e-07	0.73	0.03	0.96	FALSE