TWAS
hub
About
Usage
Models
Genes
Traits
[Hub]/) :
Traits
:
Leg fat mass (left)
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chr13:30,336,006-31,886,850
Best TWAS P=5.53e-09 · Best GWAS P=3.79e-11 conditioned to 0.00175
30.4M
30.6M
30.8M
31M
31.2M
31.4M
31.6M
31.8M
0
2
4
6
8
10
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
GTEx
Breast Mammary Tissue
HMGB1
0.26
0.02
lasso
6
0.03
9.1e-03
-6.6
5.8
5.5e-09
-0.90
0.00
0.98
TRUE
3
The Cancer Genome Atlas
Kidney Renal Clear Cell Carcinoma
HMGB1
0.08
0.04
lasso
1
0.04
6.9e-05
-5.4
5.4
8.0e-08
-0.78
0.06
0.90
FALSE
2
GTEx
Muscle Skeletal
HMGB1
0.21
0.05
lasso
6
0.08
7.1e-08
-5.0
5.3
1.0e-07
-0.74
0.05
0.94
FALSE