Best TWAS P=5.53e-09 · Best GWAS P=3.79e-11 conditioned to 0.00175
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Breast Mammary Tissue | HMGB1 | 0.26 | 0.02 | lasso | 6 | 0.03 | 9.1e-03 | -6.6 | 5.8 | 5.5e-09 | -0.90 | 0.00 | 0.98 | TRUE |
| 2 | GTEx | Muscle Skeletal | HMGB1 | 0.21 | 0.05 | lasso | 6 | 0.08 | 7.1e-08 | -5.0 | 5.3 | 1.0e-07 | -0.74 | 0.05 | 0.94 | FALSE |
| 3 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | HMGB1 | 0.08 | 0.04 | lasso | 1 | 0.04 | 6.9e-05 | -5.4 | 5.4 | 8.0e-08 | -0.78 | 0.06 | 0.90 | FALSE |