TWAS
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Models
Genes
Traits
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Traits
:
Leg fat mass (left)
:
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chr14:72,695,406-74,192,791
Best TWAS P=1.17e-08 · Best GWAS P=6.15e-06 conditioned to 0.0142
72.8M
73M
73.2M
73.4M
73.6M
73.8M
74M
74.2M
0
1
2
3
4
5
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
GTEx
Esophagus Gastroesophageal Junction
DCAF4
0.18
0.01
enet
10
0.06
3.0e-03
4
5.7
1.2e-08
0.40
0.02
0.19
TRUE
2
GTEx
Esophagus Mucosa
ZFYVE1
0.10
0.00
lasso
7
0.00
2.0e-01
4
5.4
5.1e-08
0.44
0.03
0.40
FALSE
3
GTEx
Spleen
DCAF4
0.47
0.12
enet
10
0.19
1.5e-05
4
5.1
2.7e-07
0.44
0.04
0.67
FALSE