Hub : Genes

ZFYVE1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Brain Cerebellum 0.3680 0.1260 0.00480 0.214 NA 0.121 NA 0.165 5.9e-07 NA 0.0002 NA 1.4e-05
2 GTEx Brain Cortex 0.2390 0.0870 0.00200 0.051 NA -0.002 NA 0.024 1.6e-02 NA 0.3800 NA 7.1e-02
3 GTEx Esophagus Mucosa 0.0960 0.0340 0.00058 0.002 NA -0.001 NA 0.003 2.3e-01 NA 0.3600 NA 2.0e-01
4 GTEx Skin Not Sun Exposed Suprapubic 0.1370 0.0560 0.00260 0.083 NA 0.013 NA 0.062 2.6e-05 NA 0.0620 NA 2.6e-04
5 TCGA Head and Neck Squamous Cell Carcinoma 0.0432 0.0238 0.00150 0.029 0.023 0.022 NA 0.022 3.1e-04 0.0013 0.0015 NA 1.3e-03
6 TCGA Lung Squamous Cell Carcinoma 0.0398 0.0218 0.00086 0.009 0.015 0.011 NA 0.004 2.9e-02 0.0067 0.0160 NA 9.3e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 1.1 1.7 5.9 -2.4 1.6 -1.2 -0.2 -0.2 -0.7
Bipolar Disorder or Schizophrenia 0.5 1.3 3.3 -1.8 1.0 -0.9 0.3 0.6 1.5
Depressed Affect (Nagel 2018) 0.8 1.7 3.1 1.5 0.9 1.8 0.9 -1.7 0.7
Depression (Nagel 2018) 0.8 1.2 5.1 0.9 0.5 0.7 -0.6 -2.3 -0.3
Intelligence (Savage-Jansen 2018) 3.2 9.8 24.6 -0.0 3.3 -5.0 -3.6 -2.0 -2.6
Neuroticism (Nagel 2018) 0.6 1.5 7.8 -0.1 1.0 0.4 -0.3 -2.8 -0.2
Schizophrenia (2018) 0.6 1.3 6.4 -0.4 -0.0 -0.1 0.5 1.0 2.5
Schizophrenia vs Biploar Disorder 2.4 3.1 5.2 -0.1 -1.6 2.2 2.3 1.6 1.8
Worry (Nagel 2018) 1.0 2.1 8.5 -1.8 0.7 -0.3 -0.6 -2.9 -0.2
Alzheimer’s Disease (in mother) 1.9 2.2 10.9 0.7 -0.4 -0.5 -0.9 -0.8 -3.3
Alzheimer’s Disease (in father) 0.6 0.7 2.2 0.2 -1.5 0.0 -0.6 1.1 -0.4
Alzheimer’s Disease (including proxy) 0.9 1.3 4.7 1.0 -1.3 0.2 0.2 0.6 -2.2
Crohns Disease (2017) 0.4 0.8 2.5 -0.2 0.1 -1.1 -1.6 -0.6 -0.8
Irritable Bowel Disease (IBD) 1.0 2.3 5.0 -1.5 1.3 -1.6 -2.2 -1.6 -0.3
Ulcerative Colitis (UC) 1.2 2.3 6.6 -2.6 1.6 -1.0 -1.4 -1.2 0.3
Major Depression (MDD) 0.3 0.3 1.2 -0.6 -0.4 0.2 0.3 -0.3 -1.1
Reaction Time 0.5 1.0 2.0 0.2 1.0 -1.1 -1.4 -0.7 -1.0
Verbal and Numeric Reasoning (VNR) 2.2 5.2 11.8 0.6 1.9 -3.4 -2.8 -1.3 -2.4
Breast Cancer 0.5 1.3 4.5 2.1 0.7 -0.1 -0.8 -1.1 -1.0
Ovarian Cancer 0.7 0.9 2.2 -0.9 -0.9 -0.6 -0.5 0.9 -1.5
Prostate Cancer 0.9 1.2 3.8 0.8 -0.4 0.3 -0.7 -1.4 -1.9
Age at First Birth 1.6 2.3 7.0 1.1 1.2 -1.1 -1.2 -2.6 -1.1
Bipolar Disorder (2011) 1.2 1.1 3.1 -1.8 0.8 -1.4 -0.2 0.3 1.0
Body Mass Index (BMI) (2010) 2.6 3.5 7.1 -2.1 -1.4 2.7 2.5 0.9 1.0
Coronary Artery Disease (CAD) 0.7 0.9 3.1 -1.8 0.3 -0.8 -0.2 1.1 0.5
Crohns Disease (2012) 0.6 1.0 2.7 0.9 0.1 -0.1 -1.2 -1.0 -1.6
Mean Putamen Volume 0.3 0.3 0.9 -0.9 -0.5 0.1 0.7 0.3 0.4
Fasting Glucose 0.3 0.4 0.7 -0.1 0.2 -0.6 0.8 0.8 0.9
HbA1C 1.1 1.3 3.2 -1.8 1.1 1.2 -1.1 -0.8 -0.2
HDL Cholesterol 0.1 0.2 0.6 -0.8 -0.2 -0.2 -0.6 -0.3 -0.6
LDL Cholesterol 0.6 1.0 3.6 0.8 0.9 -1.9 -0.9 0.2 0.4
Lupus 0.1 0.2 0.4 0.3 -0.6 0.2 0.6 0.5 -0.3
Neuroticism (2016) 0.6 0.8 2.7 -0.9 0.1 1.7 0.6 -1.0 -0.3
Primary Biliary Cirrhosis 0.6 0.9 2.3 -1.5 -0.4 0.5 0.3 0.5 1.5
Rheumatoid Arthritis 0.5 0.7 2.1 0.9 -1.4 -0.2 0.4 -0.6 -0.7
Schizophrenia (2014) 0.7 1.6 4.0 -1.7 -0.2 -0.5 0.6 1.4 2.0
Triglycerides 0.7 1.2 3.4 1.1 -1.9 1.2 0.9 0.6 0.5
Type 2 Diabetes (T2D) (2012) 0.2 0.2 0.7 0.4 -0.4 0.0 -0.8 -0.4 0.1
Ulcerative Colitis 0.9 1.3 2.0 -1.2 1.3 -1.2 -1.4 -0.6 0.9
Blood Eosinophil Count 1.1 8.5 17.5 0.8 -2.7 4.1 3.0 -0.2 -4.2
Blood Platelet Count 0.4 4.4 19.8 -2.5 0.7 -0.0 0.6 -0.1 4.5
Blood Red Count 3.1 29.7 77.8 0.3 -6.4 8.8 6.8 0.4 3.6
Blood White Count 0.6 4.3 12.2 -0.2 -1.4 2.5 2.3 3.5 0.2
Heel T-Score 0.2 1.9 3.4 0.6 -1.9 1.2 1.7 1.3 -1.2
BMI 2.7 15.7 53.3 -3.4 -1.8 7.3 4.0 2.7 1.6
Height 0.7 13.1 34.9 -2.4 5.2 -0.3 -2.2 -2.5 -5.9
Waist Hip Ratio (WHR) 0.3 1.2 4.4 2.1 -0.8 -0.5 -0.5 1.3 0.1
Systolic Blood Pressure 0.5 2.3 8.9 0.4 -0.1 1.0 0.4 3.0 1.8
Smoking Status 0.4 0.9 2.0 1.0 -0.6 1.4 0.4 1.4 -0.5
Allergy or Eczema 0.4 1.0 4.2 2.0 1.4 0.0 0.2 -0.1 0.3
Cardiovascular Disease 0.2 0.7 2.0 -0.8 1.1 -0.6 -0.2 1.4 0.5
Hypothyroidism (self reported) 0.3 0.8 1.9 -0.5 -0.8 -1.4 0.8 -1.1 -0.1
Respiratory disease 0.9 1.9 6.1 0.6 -0.9 2.5 1.9 0.4 0.8
Type 2 Diabetes (T2D) (2018) 1.4 2.5 4.6 0.5 -2.0 2.1 1.8 1.5 -0.9
Lung FEV1/FVC ratio 0.6 3.2 9.1 0.6 0.3 -2.6 -0.1 -1.6 3.0
Lung FVC 0.2 1.3 3.4 0.5 -0.7 1.1 0.9 1.8 -1.2
Neuroticism 0.9 2.1 7.4 -0.8 -0.4 1.8 0.9 -2.7 -0.6
Chronotype (morning person) 2.3 5.3 12.9 2.1 1.9 -0.9 -1.8 -3.6 -2.6
Hair Pigment 0.1 2.2 3.8 1.2 1.0 1.3 -1.7 -1.9 -1.4
Tanning 0.1 1.3 3.4 -0.1 1.8 -1.4 -1.1 -0.8 -1.0
Hand grip strength (left) 2.1 5.6 9.1 -2.2 3.0 0.9 -1.5 -3.0 -2.7
Number of treatments/medications taken 0.9 1.6 5.1 0.8 -0.3 1.7 0.8 2.2 -0.1
Average weekly spirits intake 1.3 1.6 4.0 -2.0 -0.0 1.5 1.2 1.3 -0.2
Sensitivity / hurt feelings 0.7 1.3 4.6 0.3 -0.4 -1.0 -0.2 -2.1 1.3
Frequency of depressed mood in last 2 weeks 0.2 0.3 1.0 -0.5 -1.0 -0.2 -0.1 -0.3 0.6
Hearing difficulty/problems: Yes 2.8 4.2 12.1 -1.0 3.5 -1.9 -2.6 -1.4 -0.3
Relative age of first facial hair 2.1 4.4 10.5 -0.5 2.0 -2.9 -3.2 -1.5 0.9
Other serious medical condition/disability diagnosed by doctor 1.1 1.4 4.5 0.5 -0.7 0.6 0.7 1.5 2.1
Ever used hormone-replacement therapy (HRT) 0.6 0.7 1.3 1.1 -1.1 -0.6 0.3 0.4 1.1
Ever had hysterectomy (womb removed) 1.5 1.6 7.3 0.4 -2.7 0.4 1.1 0.9 -0.5
Systolic blood pressure, automated reading 1.6 4.8 15.5 1.1 -0.9 3.9 1.3 3.0 0.6
Eye problems/disorders: Diabetes related eye disease 2.0 2.2 7.1 1.0 -0.6 2.7 1.7 1.2 0.2
Angina 0.6 0.8 1.6 1.3 1.0 -0.6 -0.7 0.3 1.2
Medication for hormone replacement therapy 0.6 0.7 2.0 0.3 1.1 -1.4 -1.0 0.1 -0.4
Vitamin and mineral supplements 1.5 2.0 5.4 2.3 -1.9 1.0 1.2 0.3 0.7
Supplements: Zinc 3.5 3.8 12.3 -3.5 1.8 -0.2 -1.7 -1.7 -1.2
Medication: Co-codamol 0.8 0.9 1.6 1.3 -0.7 1.3 -0.0 1.2 -0.7
Medication: Metformin 1.6 2.3 8.1 -0.4 -0.2 2.8 1.9 1.1 -0.7
Diabetes (father) 0.6 0.8 1.9 1.0 -1.4 1.0 0.8 0.4 0.3
Diabetes (mother) 0.1 0.2 0.7 -0.1 -0.2 -0.8 -0.0 0.4 0.1
Severe depression (siblings) 1.6 1.8 8.7 -0.3 0.8 -2.9 -0.7 0.9 0.6
Pack years adult smoking proportion 0.9 1.3 4.2 -0.5 -0.4 2.0 -0.9 0.6 -1.5
Impedance of leg (right) 2.5 12.2 41.9 3.9 2.4 -6.5 -3.1 -1.0 -0.3
Leg fat-free mass (left) 1.6 8.5 33.3 -3.4 -0.2 5.8 2.0 0.6 -1.5
Trunk fat percentage 0.9 3.8 10.2 -1.1 -0.9 3.2 1.9 2.5 0.7
Hand grip strength (right) 2.9 7.9 16.2 -2.7 4.0 0.0 -2.0 -3.8 -2.4
Townsend deprivation index at recruitment 6.2 8.7 15.3 0.9 -3.5 3.4 3.5 3.9 0.6
Current tobacco smoking 1.4 2.3 6.6 1.1 -2.6 1.2 0.9 1.9 -0.6
Average weekly fortified wine intake 0.7 0.8 3.0 0.7 1.7 0.4 0.3 0.1 0.9
Maternal smoking around birth 2.0 2.9 9.0 0.3 1.0 -0.1 -2.6 0.4 -3.0
Fed-up feelings 0.6 1.1 4.7 0.4 0.2 2.2 1.2 0.2 0.5
Frequency of unenthusiasm / disinterest in last 2 weeks 0.3 0.4 1.5 1.2 -0.4 -0.0 -0.2 -0.9 0.2
Relative age voice broke 1.7 2.6 7.3 -0.8 1.1 -2.7 -2.0 -0.9 1.3
Taking other prescription medications 2.1 3.3 7.1 2.1 -1.5 2.0 1.0 2.7 -0.8
Age when periods started (menarche) 2.3 5.5 12.8 1.2 1.1 -3.6 -3.1 -2.6 -1.2
Bilateral oophorectomy (both ovaries removed) 1.5 1.7 2.8 1.2 -1.7 0.6 1.6 1.6 0.7
Heel bone mineral density (BMD) T-score, automated (left) 0.6 1.4 4.7 0.9 -0.8 -0.6 -1.4 -0.2 -2.2
Tinnitus: Yes, but not now, but have in the past 2.7 2.9 6.8 0.4 -1.5 1.8 2.6 1.6 1.4
Qualifications: CSEs or equivalent 0.5 0.7 1.3 -0.4 1.1 1.1 0.0 1.1 0.5
Serious illness, injury or assault to yourself 0.3 0.4 0.8 0.3 -0.8 0.1 0.9 0.8 0.7
High blood pressure 0.3 0.8 3.4 -0.5 0.4 1.0 0.4 1.8 -0.0
Hayfever, allergic rhinitis or eczema 0.2 0.5 1.4 -0.1 1.2 -0.9 0.1 -0.6 0.7
Multivitamins +/- minerals 1.2 1.5 4.1 -1.4 2.0 -0.7 -1.2 0.9 -0.6
Stomach or abdominal pain in last month 0.4 0.5 1.8 -1.3 -0.9 -0.4 0.7 0.3 0.2
Supplements: Glucosamine 1.1 1.4 3.0 1.1 1.4 1.7 -0.1 -1.1 -1.2
Diverticular disease/diverticulitis (self-reported) 0.3 0.4 1.1 -0.5 0.2 -0.7 -1.1 0.0 -0.7
Medication: Atenolol 1.2 1.5 4.0 0.1 2.0 -0.1 -1.5 -0.1 -1.6
Medication: Levothyroxine sodium 0.6 1.0 4.9 -0.6 0.2 -0.3 0.7 -2.2 0.6
Sitting height 0.7 4.9 12.1 -3.5 3.0 0.7 -0.5 -0.0 -2.8
Chronic bronchitis/emphysema (father) 1.0 1.2 2.9 0.0 1.0 0.5 0.6 -1.7 -1.7
High blood pressure (mother) 0.4 0.6 1.4 1.0 0.2 -1.2 0.2 0.2 1.1
Body mass index (BMI) 2.6 11.2 38.8 -2.2 -1.9 6.2 3.2 2.9 1.3
Impedance of leg (left) 2.3 11.1 39.9 3.4 2.1 -6.3 -3.2 -0.8 -0.4
Leg predicted mass (left) 1.6 8.6 33.2 -3.4 -0.2 5.8 2.0 0.6 -1.5
Trunk fat mass 1.3 5.6 20.1 -1.7 -0.6 4.5 2.0 2.4 -0.0
Waist circumference 1.9 6.8 21.5 -1.1 -1.6 4.6 2.5 2.9 1.0
Number of incorrect matches in round 0.8 1.3 3.3 -1.2 0.0 1.8 1.1 0.4 -1.3
Past tobacco smoking 0.4 0.7 1.6 -1.3 -0.9 -1.1 0.2 -0.5 0.4
Alcohol usually taken with meals 0.5 0.8 2.9 -0.7 0.7 -0.4 0.7 -1.7 0.6
Nervous feelings 1.4 2.5 6.9 -2.2 0.7 -0.9 -1.1 -2.6 -0.9
Frequency of tenseness / restlessness in last 2 weeks 1.2 1.8 3.7 -0.7 1.9 -0.1 -1.4 -1.9 -1.1
Hearing difficulty/problems with background noise 1.2 1.9 4.1 -1.7 2.0 -0.7 -1.4 -1.2 -0.9
Hair/balding pattern: Pattern 2 1.8 2.3 4.4 -1.7 -0.8 0.1 2.1 1.8 1.6
Had menopause 0.7 0.9 4.8 2.2 -0.2 0.3 0.0 -0.3 0.5
Had other major operations 2.1 2.6 6.4 0.0 -2.5 2.0 1.8 1.3 0.3
Forced vital capacity (FVC) 0.6 2.3 8.9 -1.1 1.9 -0.1 -0.3 0.3 -3.0
Heel bone mineral density (BMD) T-score, automated (right) 0.8 1.7 6.2 0.7 -1.8 0.6 -0.1 0.3 -2.5
Ever unenthusiastic/disinterested for a whole week 0.8 0.9 2.8 -1.7 -0.5 -1.0 0.2 0.7 1.0
Qualifications: None of the above 2.2 4.6 6.9 -0.6 -2.6 2.6 2.6 1.7 2.1
Financial difficulties in last 2 years 4.1 5.5 14.1 0.3 -3.8 0.5 3.2 0.1 2.9
Mouth/teeth dental problems 0.4 0.5 1.6 0.4 0.6 -1.2 0.8 0.1 0.8
Heart attack 0.4 0.5 1.0 0.4 0.4 -0.9 -0.9 -1.0 -0.5
Allergy 0.4 1.0 2.8 -1.0 0.7 -1.1 -1.7 0.1 -0.9
Pain all over the body in last month 0.9 0.9 2.1 1.4 0.6 0.8 0.6 -0.1 1.5
Diabetes (self-reported) 1.9 2.9 8.4 0.2 -1.2 2.9 1.7 2.2 -0.6
Hayfever/allergic rhinitis (self-reported) 0.2 0.2 0.6 -0.1 0.6 -0.4 0.2 -0.8 0.2
Medication: Ramipril 0.3 0.4 0.8 -0.7 0.9 0.7 -0.5 0.1 -0.5
Medication: Simvastatin 0.6 0.8 3.6 -1.9 -0.8 -0.2 0.8 -0.4 0.0
Fluid intelligence score 3.4 7.0 15.3 0.7 2.6 -3.9 -3.3 -2.0 -2.2
Illnesses of siblings 0.4 0.5 1.1 -0.4 -0.9 -0.1 0.9 1.0 0.3
Neuroticism score 0.7 1.4 7.1 -0.8 0.1 0.6 0.1 -2.7 -0.4
Weight 1.8 8.8 34.1 -2.7 -0.6 5.8 2.6 1.9 -0.5
Impedance of arm (right) 2.6 12.0 50.4 2.8 2.6 -7.1 -2.5 -0.8 0.5
Arm fat percentage (right) 1.7 6.9 17.4 -1.1 -1.3 4.2 2.8 3.2 1.7
Trunk fat-free mass 1.2 7.1 29.1 -2.8 0.1 5.4 1.7 -0.2 -1.7
Hip circumference 1.3 5.8 20.4 -1.7 -0.7 4.5 2.4 2.0 0.9
Time employed in main current job 2.3 2.7 8.3 0.1 1.7 1.2 -0.8 -2.9 -1.6
Alcohol intake versus 10 years previously 3.3 4.9 12.5 0.3 -3.5 2.2 2.8 1.0 1.7
Father’s age at death 2.3 3.1 13.2 1.1 0.0 -1.4 -1.1 -3.6 -1.1
Worrier / anxious feelings 1.5 2.8 11.0 -1.2 0.3 -1.4 -1.3 -3.3 -0.8
Frequency of tiredness / lethargy in last 2 weeks 1.5 2.5 6.8 -0.6 -1.9 1.7 2.6 1.1 0.4
Falls in the last year 0.6 0.8 2.6 0.8 -1.0 0.5 1.6 -0.3 0.6
Hair/balding pattern: Pattern 3 0.9 1.4 4.1 0.6 0.6 -1.1 -1.4 -2.0 -0.3
Number of live births 1.0 1.5 4.5 -2.1 -1.2 0.8 1.1 0.6 0.9
Forced expiratory volume in 1-second (FEV1) 0.3 0.9 1.8 -1.3 1.3 -0.3 0.4 0.1 -1.3
Pulse rate 1.0 1.7 4.7 0.4 -0.5 1.0 1.8 1.0 2.2
Happiness 1.9 2.3 6.1 0.5 2.5 -0.7 -1.8 -0.7 -1.8
Noisy workplace 3.0 3.7 8.2 0.7 -1.3 2.9 2.6 2.2 0.5
Qualifications: A levels/AS levels or equivalent 1.8 4.1 6.7 -0.5 2.4 -2.4 -2.3 -2.6 -0.9
Serious illness, injury or assault of a close relative in last 2 years 0.5 0.6 1.8 -1.1 -0.4 -0.4 0.3 -0.3 1.3
Mouth/teeth dental problems: Dentures 2.8 4.8 13.3 1.3 -0.1 1.6 -2.4 -2.3 -3.6
Asthma 1.2 2.4 5.0 0.8 -1.5 2.2 2.2 1.1 0.4
Medication: Ibuprofen (e.g. Nurofen) 1.3 1.7 3.7 -1.9 -1.0 -0.1 1.4 1.3 1.4
Medication: Cholesterol lowering 0.5 0.8 2.1 0.1 1.1 0.7 -0.8 0.4 -1.4
Depression (self-reported) 0.9 1.1 3.0 -1.7 0.1 -0.9 -1.2 -0.4 -0.9
Medication: Lansoprazole 2.3 2.6 6.7 2.0 0.4 1.5 -0.4 -1.4 -2.6
Prospective memory result 4.6 5.7 10.5 0.3 -2.9 2.5 2.6 3.2 1.5
Lung cancer (father) 1.7 1.9 4.2 -1.4 -1.1 2.0 1.7 1.1 -0.2
Illnesses of mother 0.5 0.7 2.0 -1.4 0.0 0.4 -0.4 -0.9 -1.0
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 1.0 2.4 -1.0 1.3 -0.7 -0.0 0.5 -1.5
Pulse wave Arterial Stiffness index 1.1 1.3 3.6 0.8 0.7 1.3 1.1 1.9 0.4
Impedance of arm (left) 2.1 9.6 40.8 2.9 2.0 -6.4 -1.9 -0.8 -0.0
Arm fat mass (right) 2.3 9.3 31.3 -2.0 -1.4 5.6 2.9 3.0 0.8
Trunk predicted mass 1.2 7.1 29.4 -2.6 0.1 5.4 1.7 -0.1 -1.7
Standing height 0.5 4.9 15.4 -1.5 2.8 0.1 -1.0 -1.9 -3.9
Length of working week for main job 1.4 1.5 3.3 0.5 -1.6 1.1 1.8 1.2 -0.5
Exposure to tobacco smoke at home 1.0 1.1 2.1 0.4 -1.3 0.7 1.4 1.2 0.8
Breastfed as a baby 0.8 1.0 2.7 0.9 1.1 -1.6 -1.1 0.0 -0.5
Tense / ‘highly strung’ 1.6 2.7 6.7 -2.3 1.1 -0.5 -1.0 -2.6 -1.4
Seen doctor (GP) for nerves, anxiety, tension or depression 1.5 2.2 4.5 -1.6 1.9 -2.1 -1.8 -0.0 -0.2
Hair/balding pattern: Pattern 4 0.1 0.3 0.7 0.2 -0.1 -0.1 -0.8 -0.8 -0.8
Birth weight of first child 0.8 1.4 4.8 -0.6 0.7 0.3 -0.8 1.3 -2.2
Peak expiratory flow (PEF) 0.5 1.0 3.0 -1.7 1.2 0.6 1.0 0.5 -0.4
Pulse wave reflection index 0.9 1.2 4.3 2.1 1.1 -0.2 -0.3 0.8 -0.8
Ever highly irritable/argumentative for 2 days 0.5 0.6 2.6 -1.6 0.1 -0.2 -0.4 -0.4 -0.6
Loud music exposure frequency 0.7 0.8 2.6 0.8 0.9 -1.6 -0.6 0.4 -0.4
Qualifications: O levels/GCSEs or equivalent 3.5 5.6 10.0 0.0 2.3 -2.9 -3.2 -2.9 -1.1
Mouth/teeth dental problems: Bleeding gums 3.1 4.0 7.8 -2.6 -1.3 1.2 2.3 0.9 2.8
Blood clot in the leg (DVT) 2.8 3.7 8.4 2.8 -2.9 0.0 2.2 0.3 1.0
Medication: Paracetamol 1.2 1.9 5.8 -2.4 -0.4 0.7 0.6 1.6 1.4
Headache pain in last month 1.5 2.6 6.9 -2.4 0.4 0.5 1.4 2.6 0.8
Medication for cholesterol, blood pressure or diabetes 0.4 0.6 1.4 -0.4 -0.6 -1.2 0.6 -0.7 1.0
Glaucoma (self-reported) 0.5 0.6 2.9 0.2 0.2 -0.8 0.3 -0.1 -1.7
Gout (self-reported) 0.8 1.1 3.2 0.1 -0.5 -1.4 -0.8 1.8 0.7
Hypothyroidism/myxoedema (self-reported) 0.3 0.7 2.1 -0.2 -0.5 -0.5 1.2 -1.5 0.1
Medication: Amlodipine 1.1 1.6 4.5 -0.2 -0.2 2.1 0.7 1.5 1.4
Medication: Ventolin 100micrograms inhaler 1.0 1.3 2.7 -0.4 -1.6 0.9 1.4 0.7 1.3
Birth weight 0.6 1.3 2.9 -1.7 0.4 0.4 -0.7 -1.3 -1.7
Chronic bronchitis/emphysema (mother) 0.4 0.4 1.2 1.1 0.6 -0.2 -0.7 -0.0 0.7
High blood pressure (siblings) 1.0 1.4 2.8 0.0 1.6 -0.9 -1.7 -1.3 -0.8
Forced vital capacity (FVC), Best measure 0.6 2.3 8.0 -1.2 1.9 -0.1 -0.1 1.0 -2.8
Body fat percentage 1.2 4.7 14.2 -0.9 -1.0 3.8 2.1 2.7 0.9
Leg fat percentage (right) 1.2 4.3 17.0 -0.4 -0.3 4.1 1.5 2.4 0.9
Arm fat-free mass (right) 1.8 9.4 35.8 -3.4 -0.9 6.0 2.2 0.6 -1.7
Exposure to tobacco smoke outside home 1.8 2.4 5.7 -0.9 -2.4 1.1 1.7 1.3 1.3
Comparative body size at age 10 1.1 3.1 10.6 -2.3 0.4 3.3 -0.0 0.1 -1.6
Number of full brothers 1.0 1.3 3.7 1.2 -0.8 0.4 -0.5 -1.1 -1.9
Worry too long after embarrassment 1.1 1.8 7.9 -0.3 -1.2 -1.1 0.4 -2.8 0.5
Seen a psychiatrist for nerves, anxiety, tension or depression 0.7 0.9 4.2 -2.0 -0.4 -0.7 -0.0 0.1 0.7
Wheeze or whistling in the chest in last year 0.2 0.4 1.4 0.1 1.2 0.8 -0.2 -0.6 0.4
Number of children fathered 0.6 0.6 1.3 -0.3 0.7 0.7 -0.7 -1.1 -1.0
Reason for reducing amount of alcohol drunk: Health precaution 0.5 0.6 2.2 -0.0 0.4 -1.5 -0.4 -1.0 0.1
Age at first live birth 1.2 2.1 3.4 1.6 1.8 -1.4 -1.8 -0.7 -0.7
Pulse wave peak to peak time 1.1 1.3 3.2 -1.0 -0.5 -1.2 -1.1 -1.8 -0.7
Health satisfaction 1.4 1.8 3.3 -1.7 -1.2 0.0 1.1 1.3 1.8
Shortness of breath walking on level ground 0.6 0.7 1.9 -0.0 -0.6 0.4 1.3 0.2 1.4
Qualifications: College or University degree 1.3 4.1 9.6 -0.7 3.1 -1.7 -1.3 -1.8 -2.6
Eye problems/disorders: None of the above 1.9 2.2 7.4 0.7 0.0 -2.7 -0.7 1.5 1.5
Mouth/teeth dental problems: Loose teeth 0.3 0.4 1.0 -0.6 -0.3 1.0 0.5 0.2 -0.7
Emphysema/chronic bronchitis 2.1 2.4 4.4 1.2 -2.1 1.9 1.3 0.5 1.7
Medication for pain relief, constipation, heartburn 0.8 1.4 4.1 2.0 1.5 -0.7 -0.2 -1.2 -0.3
Neck or shoulder pain in last month 1.4 1.9 4.4 -0.3 -1.8 -0.2 0.8 1.8 2.1
Medication: Blood pressure 0.6 1.1 3.7 1.3 -0.4 1.9 0.2 -0.3 -1.1
Angina (self-reported) 0.4 0.6 0.8 0.8 0.9 -0.6 -0.9 0.1 0.9
Migraine (self-reported) 2.7 3.4 7.2 -2.7 0.8 -2.1 -0.5 2.3 1.6
Medication: Ibuprofen 1.1 1.4 2.9 -1.7 -0.6 0.1 1.4 1.1 1.3
Medication: Allopurinol 0.8 1.1 4.2 0.2 -1.4 0.0 0.4 2.1 0.6
Medication: Omeprazole 0.5 0.6 0.9 0.7 -0.6 0.9 -0.2 -1.0 -0.8
Medication: Seretide 50 evohaler 0.6 0.7 3.0 -0.0 1.0 0.1 0.4 1.7 0.4
Mean time to correctly identify matches 0.9 1.6 3.9 1.0 1.0 -1.7 -2.0 -0.5 -0.8
Heart disease (mother) 1.2 1.4 2.7 -1.6 1.2 -1.6 -1.0 0.6 0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.4 0.4 1.8 -0.5 1.4 -0.2 -0.2 -0.3 0.6
Whole body fat mass 1.8 7.4 28.4 -1.7 -0.9 5.3 2.4 2.6 0.1
Leg fat mass (right) 1.7 6.6 27.3 -1.8 -0.3 5.2 2.0 2.2 -0.0
Arm predicted mass (right) 1.8 9.1 35.4 -3.2 -0.9 5.9 2.1 0.5 -1.8
Pulse rate, automated reading 0.4 1.2 2.7 1.1 -0.0 1.2 0.6 1.2 1.6
Alcohol intake frequency. 4.0 9.4 20.5 0.6 -4.5 1.6 4.1 0.5 4.0
Comparative height size at age 10 0.3 1.7 5.9 0.5 -0.6 1.9 0.5 -0.4 -2.4
Number of full sisters 1.8 2.2 9.9 0.6 1.1 -3.1 -1.4 0.3 -0.3
Suffer from ‘nerves’ 1.3 2.0 3.0 -1.7 1.7 -1.5 -1.5 -1.2 -0.4
Overall health rating 1.2 2.6 5.2 -2.3 -1.0 2.1 1.3 1.9 0.2
Chest pain or discomfort 0.6 0.9 2.1 -1.4 0.8 0.7 0.1 -1.0 1.0
Had major operations 0.4 0.5 1.4 1.2 -0.5 0.7 -0.0 0.5 -0.8
Age at last live birth 0.3 0.5 1.6 1.3 0.3 -0.7 -0.2 -0.2 0.8
Family relationship satisfaction 1.4 1.7 3.5 0.1 1.6 -1.9 -1.6 0.5 -1.2
Leg pain on walking 0.9 1.1 3.4 -0.5 -1.8 0.1 1.2 1.0 0.9
Qualifications: NVQ or HND or HNC or equivalent 1.8 2.1 6.8 0.6 -0.9 1.0 1.6 1.0 2.6
Commuting to job workplace: Car/motor vehicle 0.3 0.4 0.9 0.6 1.0 0.0 -0.8 -0.2 0.5
Illness, injury, bereavement, stress in last 2 years 1.6 1.9 4.2 -0.3 1.8 1.6 -0.8 0.9 -2.0
Medication: Aspirin 0.9 1.2 2.6 0.1 -0.2 -0.9 -1.6 -1.4 -1.3
Supplements: Vitamin C 0.4 0.5 1.1 -0.9 0.8 -0.4 -0.3 -1.1 -0.1
Knee pain experienced in last month 1.4 2.2 7.7 -1.3 -1.1 2.8 1.5 0.2 0.1
Hypertension (Self-reported) 0.2 0.7 3.1 -0.5 0.5 0.5 0.3 1.8 0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.9 2.3 5.5 2.3 -0.3 1.5 -0.3 -1.9 -1.4
Illnesses of father: Heart disease 1.9 2.6 6.0 -2.4 1.8 -1.9 -1.5 -0.4 0.3
Illnesses of siblings: Diabetes 2.0 2.4 5.7 0.9 -2.4 1.3 1.4 2.0 0.5
Smoking status: Previous 0.5 0.7 2.3 0.6 1.5 0.9 -0.7 0.5 0.0
Forced expiratory volume in 1-second (FEV1), predicted 0.4 0.9 2.1 -1.2 0.3 0.4 0.3 1.5 -1.2
Whole body fat-free mass 1.5 8.8 35.0 -3.3 -0.3 5.9 2.0 0.1 -1.7
Leg fat-free mass (right) 1.8 9.5 35.3 -3.8 -0.6 5.9 2.2 0.6 -1.5
Arm fat percentage (left) 1.8 7.1 18.6 -1.0 -1.6 4.3 2.9 3.2 1.4
Average weekly red wine intake 1.2 1.7 2.7 -0.3 1.6 -1.5 -1.3 -1.0 -1.6
Handedness (chirality/laterality): Left-handed 0.7 0.8 1.5 -0.1 0.7 -1.0 -0.7 1.1 -1.2
Mood swings 0.1 0.3 1.1 -0.0 1.1 0.5 0.3 -0.3 0.3
Loneliness, isolation 0.3 0.4 1.8 1.4 0.7 0.1 -0.3 0.0 0.0
Long-standing illness, disability or infirmity 2.9 4.5 6.9 -0.5 -2.6 2.0 2.2 2.2 2.4
Ever had bowel cancer screening 0.1 0.1 0.4 0.6 -0.4 -0.4 -0.4 -0.1 0.0
Diabetes diagnosed by doctor 1.6 2.7 7.8 0.4 -1.0 2.8 1.7 2.0 -0.6
Ever had stillbirth, spontaneous miscarriage or termination 0.3 0.3 0.9 -0.3 -0.5 -0.9 -0.7 0.1 -0.2
Friendships satisfaction 5.2 6.4 12.9 1.0 2.9 -3.3 -3.6 -1.1 -1.9
Qualifications: nursing, teaching 1.6 2.5 3.6 -0.2 1.9 -1.9 -1.8 -1.4 -1.5
Commuting to job workplace: Walk 0.2 0.2 0.5 -0.7 0.4 -0.7 0.1 -0.5 0.2
Eye problems/disorders: Cataract 0.9 1.0 2.5 0.2 -0.1 1.6 1.3 -1.3 0.4
Mouth/teeth dental problems: Mouth ulcers 0.7 1.2 4.4 0.5 0.1 -0.9 -0.2 2.1 1.2
Medication for cholesterol 0.3 0.5 0.8 0.8 -0.9 0.9 0.4 -0.6 0.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.3 1.5 5.1 -0.9 0.1 1.6 -0.4 0.7 -2.2
Back pain experienced in last month 1.6 2.3 4.0 -1.7 -2.0 1.4 1.0 0.8 1.8
Mineral and other dietary supplements 1.6 2.2 5.9 0.6 -1.4 -1.6 0.3 1.4 2.4
Breast cancer (self-reported) 1.6 1.9 4.0 -1.0 -1.9 2.0 1.1 1.1 -0.0
Asthma (self-reported) 1.2 2.5 5.3 0.8 -1.4 2.3 2.3 1.2 0.6
Osteoporosis (self-reported) 2.9 3.6 6.8 2.1 0.6 -2.3 -2.6 -2.1 0.6
Osteoarthritis (self-reported) 1.6 2.1 6.7 0.9 -1.4 2.6 0.3 -0.4 -1.7
Medication: Aspirin 1.1 1.4 3.6 0.4 -0.2 -1.1 -1.9 -1.1 -1.5
Medication: Gliclazide 0.3 0.3 1.0 0.6 -0.1 0.2 -0.5 0.4 -1.0
Illnesses of father: None of the above (group 1) 0.4 0.5 1.4 0.2 -0.9 1.2 0.6 0.1 0.4
Smoking status: Current 1.6 2.6 6.9 1.6 -2.6 1.3 1.2 1.6 -0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.8 2.7 -0.5 0.8 -0.6 -0.1 -0.8 -1.6
Whole body water mass 1.6 8.9 35.4 -3.3 -0.4 6.0 2.1 0.4 -1.6
Leg predicted mass (right) 1.8 9.6 35.6 -3.7 -0.5 6.0 2.1 0.6 -1.6
Arm fat mass (left) 2.0 8.2 29.5 -2.0 -1.2 5.4 2.8 2.5 0.4
Number of self-reported non-cancer illnesses 1.6 2.8 10.0 -0.0 -1.8 0.7 1.5 3.2 0.9
Average weekly champagne plus white wine intake 1.6 2.3 12.0 -0.8 -0.3 -0.0 -0.5 -3.5 -0.8
Miserableness 0.5 0.9 2.2 1.5 0.3 0.8 0.5 -1.4 -0.1
Guilty feelings 0.3 0.4 1.1 -0.6 1.1 0.6 0.1 -0.7 -0.3
Wears glasses or contact lenses 0.7 0.8 3.7 0.2 -0.3 1.9 0.8 -0.1 0.0
Ever taken oral contraceptive pill 0.5 0.6 1.8 1.3 0.7 -0.6 -0.5 -0.1 -0.6
Hearing aid user 0.4 0.4 1.6 0.4 0.3 -0.7 -0.4 1.3 0.0
Mother’s age at death 1.5 1.9 4.5 0.1 1.1 -2.1 -1.4 -1.9 -0.2
Financial situation satisfaction 2.2 2.7 5.2 -0.0 -2.1 1.0 2.0 1.3 2.3
Tinnitus: Yes, now most or all of the time 0.6 0.7 1.8 1.0 0.8 -1.0 -1.4 0.2 0.0
Commuting to job workplace: Public transport 0.2 0.2 0.5 -0.7 -0.5 0.5 0.5 0.4 -0.3
Eye problems/disorders: Glaucoma 0.6 0.7 3.9 -0.2 0.5 0.1 0.2 -0.1 -2.0
Medication: Blood pressure 0.4 0.8 2.9 -0.7 1.7 -0.2 -0.4 0.7 0.9
Pain type(s) experienced in last month: Hip pain 0.7 0.9 2.5 -0.5 -0.6 1.1 0.2 1.6 -1.1
Supplements: Fish oil (including cod liver oil) 1.3 1.6 4.0 -1.1 1.2 1.7 0.1 0.1 -2.0
High cholesterol (Self-reported) 0.1 0.1 0.3 0.5 0.2 -0.5 -0.4 0.1 -0.1
Medication: Bendroflumethiazide 0.2 0.3 0.7 -0.8 0.8 0.5 0.1 0.1 -0.2
Medication: Paracetamol 1.1 1.7 6.7 -2.6 0.2 1.0 0.5 1.0 1.2
Medication: Lisinopril 1.5 1.9 4.8 0.7 -2.2 1.9 1.5 0.3 -0.2
Medication: Atorvastatin 0.9 1.1 2.6 1.5 0.3 1.2 0.3 1.6 -0.2
Illnesses of father: High blood pressure 0.2 0.2 0.5 0.4 0.0 -0.7 0.1 0.7 0.2
Alcohol drinker status: Never 2.9 3.5 8.7 0.5 -3.0 -0.9 2.2 0.5 2.5
Ever smoked 0.2 0.3 0.9 0.8 0.4 0.4 -0.1 0.5 -0.9
Basal metabolic rate 1.7 9.3 36.8 -3.4 -0.5 6.1 2.3 0.7 -1.4
Leg fat percentage (left) 1.4 5.0 19.9 -0.6 -0.5 4.5 1.6 2.6 0.8
Arm fat-free mass (left) 1.8 9.1 35.4 -3.5 -0.7 5.9 2.0 0.7 -1.3
Number of operations (self-reported) 3.8 5.7 11.8 0.8 -3.4 2.5 2.0 3.3 -0.7
Average weekly beer plus cider intake 2.1 3.0 5.1 -0.9 1.9 0.4 -1.9 2.3 -2.2
Irritability 1.5 2.5 7.0 -1.1 -0.3 1.0 -0.4 -2.4 -2.6
Risk taking 0.5 0.7 1.5 0.8 -0.2 -0.7 -0.8 -1.2 -1.0
Ever had prostate specific antigen (PSA) test 0.2 0.3 0.7 0.2 0.1 -0.7 -0.5 0.8 -0.0
Fractured/broken bones in last 5 years 0.6 0.8 3.6 -0.1 0.0 -0.9 0.3 0.6 1.9
Age started oral contraceptive pill 1.3 1.6 6.7 2.6 -0.3 -0.9 -0.3 -1.3 0.4
Diastolic blood pressure, automated reading 0.3 1.0 2.6 1.3 1.1 -0.4 -1.6 -0.5 0.2
Ever depressed for a whole week 3.0 3.7 8.0 -2.8 0.8 -2.7 -0.1 1.3 2.1
Unable to work because of sickness or disability 1.2 1.5 4.9 1.1 -0.8 2.2 0.7 1.3 -0.1
Commuting to job workplace: Cycle 1.7 2.1 4.1 0.6 1.8 -2.0 -1.4 -1.5 -0.8
Myopia 0.5 0.8 3.2 0.2 -0.3 -1.8 -1.1 -0.3 0.5
Vascular/heart problems diagnosed by doctor 0.3 0.9 3.1 0.1 -0.1 -1.3 -0.6 -1.8 -0.4
Cholesterol lowering medication 0.6 0.9 2.3 -0.8 -1.5 0.1 1.4 0.4 0.7
Medication: Omeprazole (e.g. Zanprol) 0.7 0.9 1.9 0.9 -0.4 0.4 -0.7 -1.4 -1.4
Pain experienced in last month 0.9 1.5 5.5 2.4 0.3 -1.1 -0.7 -1.1 -0.9
Supplements: Calcium 1.7 1.9 8.2 -0.4 1.0 -0.5 -1.2 -2.9 0.1
Basal cell carcinoma (self-reported) 0.4 0.4 1.8 -0.0 -0.0 1.3 0.1 -0.2 -0.9
Heart attack/myocardial infarction (self-reported) 0.5 0.6 1.1 0.3 0.8 -0.8 -1.0 -0.9 -0.7
Deep venous thrombosis (DVT) (self-reported) 2.8 3.6 7.7 2.6 -2.8 0.3 2.4 0.3 1.0
Heart disease (siblings) 0.5 0.6 2.1 -0.6 0.8 -0.7 -0.0 -0.1 1.4
Alcohol drinker status: Previous 1.1 1.2 2.9 1.5 -0.7 1.7 0.6 1.1 0.2
Pack years of smoking 0.8 1.2 4.0 -0.1 -0.4 2.0 -1.1 0.2 -1.3
Impedance of whole body 2.4 12.0 49.7 2.8 2.2 -7.0 -2.9 -0.9 -0.1
Leg fat mass (left) 1.8 6.9 29.7 -1.7 -0.4 5.4 2.0 2.2 -0.2
Arm predicted mass (left) 1.9 9.6 37.9 -3.6 -0.5 6.2 1.9 0.5 -1.6