Hub : Genes

ZFYVE1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellum	0.3680	0.1260	0.00480	0.214	NA	0.121	NA	0.165	5.9e-07	NA	0.0002	NA	1.4e-05
2	GTEx	Brain Cortex	0.2390	0.0870	0.00200	0.051	NA	-0.002	NA	0.024	1.6e-02	NA	0.3800	NA	7.1e-02
3	GTEx	Esophagus Mucosa	0.0960	0.0340	0.00058	0.002	NA	-0.001	NA	0.003	2.3e-01	NA	0.3600	NA	2.0e-01
4	GTEx	Skin Not Sun Exposed Suprapubic	0.1370	0.0560	0.00260	0.083	NA	0.013	NA	0.062	2.6e-05	NA	0.0620	NA	2.6e-04
5	TCGA	Head and Neck Squamous Cell Carcinoma	0.0432	0.0238	0.00150	0.029	0.023	0.022	NA	0.022	3.1e-04	0.0013	0.0015	NA	1.3e-03
6	TCGA	Lung Squamous Cell Carcinoma	0.0398	0.0218	0.00086	0.009	0.015	0.011	NA	0.004	2.9e-02	0.0067	0.0160	NA	9.3e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	1.1	1.7	5.9	-2.4	1.6	-1.2	-0.2	-0.2	-0.7
Bipolar Disorder or Schizophrenia	0.5	1.3	3.3	-1.8	1.0	-0.9	0.3	0.6	1.5
Depressed Affect (Nagel 2018)	0.8	1.7	3.1	1.5	0.9	1.8	0.9	-1.7	0.7
Depression (Nagel 2018)	0.8	1.2	5.1	0.9	0.5	0.7	-0.6	-2.3	-0.3
Intelligence (Savage-Jansen 2018)	3.2	9.8	24.6	-0.0	3.3	-5.0	-3.6	-2.0	-2.6
Neuroticism (Nagel 2018)	0.6	1.5	7.8	-0.1	1.0	0.4	-0.3	-2.8	-0.2
Schizophrenia (2018)	0.6	1.3	6.4	-0.4	-0.0	-0.1	0.5	1.0	2.5
Schizophrenia vs Biploar Disorder	2.4	3.1	5.2	-0.1	-1.6	2.2	2.3	1.6	1.8
Worry (Nagel 2018)	1.0	2.1	8.5	-1.8	0.7	-0.3	-0.6	-2.9	-0.2
Alzheimer’s Disease (in mother)	1.9	2.2	10.9	0.7	-0.4	-0.5	-0.9	-0.8	-3.3
Alzheimer’s Disease (in father)	0.6	0.7	2.2	0.2	-1.5	0.0	-0.6	1.1	-0.4
Alzheimer’s Disease (including proxy)	0.9	1.3	4.7	1.0	-1.3	0.2	0.2	0.6	-2.2
Crohns Disease (2017)	0.4	0.8	2.5	-0.2	0.1	-1.1	-1.6	-0.6	-0.8
Irritable Bowel Disease (IBD)	1.0	2.3	5.0	-1.5	1.3	-1.6	-2.2	-1.6	-0.3
Ulcerative Colitis (UC)	1.2	2.3	6.6	-2.6	1.6	-1.0	-1.4	-1.2	0.3
Major Depression (MDD)	0.3	0.3	1.2	-0.6	-0.4	0.2	0.3	-0.3	-1.1
Reaction Time	0.5	1.0	2.0	0.2	1.0	-1.1	-1.4	-0.7	-1.0
Verbal and Numeric Reasoning (VNR)	2.2	5.2	11.8	0.6	1.9	-3.4	-2.8	-1.3	-2.4
Breast Cancer	0.5	1.3	4.5	2.1	0.7	-0.1	-0.8	-1.1	-1.0
Ovarian Cancer	0.7	0.9	2.2	-0.9	-0.9	-0.6	-0.5	0.9	-1.5
Prostate Cancer	0.9	1.2	3.8	0.8	-0.4	0.3	-0.7	-1.4	-1.9
Age at First Birth	1.6	2.3	7.0	1.1	1.2	-1.1	-1.2	-2.6	-1.1
Bipolar Disorder (2011)	1.2	1.1	3.1	-1.8	0.8	-1.4	-0.2	0.3	1.0
Body Mass Index (BMI) (2010)	2.6	3.5	7.1	-2.1	-1.4	2.7	2.5	0.9	1.0
Coronary Artery Disease (CAD)	0.7	0.9	3.1	-1.8	0.3	-0.8	-0.2	1.1	0.5
Crohns Disease (2012)	0.6	1.0	2.7	0.9	0.1	-0.1	-1.2	-1.0	-1.6
Mean Putamen Volume	0.3	0.3	0.9	-0.9	-0.5	0.1	0.7	0.3	0.4
Fasting Glucose	0.3	0.4	0.7	-0.1	0.2	-0.6	0.8	0.8	0.9
HbA1C	1.1	1.3	3.2	-1.8	1.1	1.2	-1.1	-0.8	-0.2
HDL Cholesterol	0.1	0.2	0.6	-0.8	-0.2	-0.2	-0.6	-0.3	-0.6
LDL Cholesterol	0.6	1.0	3.6	0.8	0.9	-1.9	-0.9	0.2	0.4
Lupus	0.1	0.2	0.4	0.3	-0.6	0.2	0.6	0.5	-0.3
Neuroticism (2016)	0.6	0.8	2.7	-0.9	0.1	1.7	0.6	-1.0	-0.3
Primary Biliary Cirrhosis	0.6	0.9	2.3	-1.5	-0.4	0.5	0.3	0.5	1.5
Rheumatoid Arthritis	0.5	0.7	2.1	0.9	-1.4	-0.2	0.4	-0.6	-0.7
Schizophrenia (2014)	0.7	1.6	4.0	-1.7	-0.2	-0.5	0.6	1.4	2.0
Triglycerides	0.7	1.2	3.4	1.1	-1.9	1.2	0.9	0.6	0.5
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.7	0.4	-0.4	0.0	-0.8	-0.4	0.1
Ulcerative Colitis	0.9	1.3	2.0	-1.2	1.3	-1.2	-1.4	-0.6	0.9
Blood Eosinophil Count	1.1	8.5	17.5	0.8	-2.7	4.1	3.0	-0.2	-4.2
Blood Platelet Count	0.4	4.4	19.8	-2.5	0.7	-0.0	0.6	-0.1	4.5
Blood Red Count	3.1	29.7	77.8	0.3	-6.4	8.8	6.8	0.4	3.6
Blood White Count	0.6	4.3	12.2	-0.2	-1.4	2.5	2.3	3.5	0.2
Heel T-Score	0.2	1.9	3.4	0.6	-1.9	1.2	1.7	1.3	-1.2
BMI	2.7	15.7	53.3	-3.4	-1.8	7.3	4.0	2.7	1.6
Height	0.7	13.1	34.9	-2.4	5.2	-0.3	-2.2	-2.5	-5.9
Waist Hip Ratio (WHR)	0.3	1.2	4.4	2.1	-0.8	-0.5	-0.5	1.3	0.1
Systolic Blood Pressure	0.5	2.3	8.9	0.4	-0.1	1.0	0.4	3.0	1.8
Smoking Status	0.4	0.9	2.0	1.0	-0.6	1.4	0.4	1.4	-0.5
Allergy or Eczema	0.4	1.0	4.2	2.0	1.4	0.0	0.2	-0.1	0.3
Cardiovascular Disease	0.2	0.7	2.0	-0.8	1.1	-0.6	-0.2	1.4	0.5
Hypothyroidism (self reported)	0.3	0.8	1.9	-0.5	-0.8	-1.4	0.8	-1.1	-0.1
Respiratory disease	0.9	1.9	6.1	0.6	-0.9	2.5	1.9	0.4	0.8
Type 2 Diabetes (T2D) (2018)	1.4	2.5	4.6	0.5	-2.0	2.1	1.8	1.5	-0.9
Lung FEV1/FVC ratio	0.6	3.2	9.1	0.6	0.3	-2.6	-0.1	-1.6	3.0
Lung FVC	0.2	1.3	3.4	0.5	-0.7	1.1	0.9	1.8	-1.2
Neuroticism	0.9	2.1	7.4	-0.8	-0.4	1.8	0.9	-2.7	-0.6
Chronotype (morning person)	2.3	5.3	12.9	2.1	1.9	-0.9	-1.8	-3.6	-2.6
Hair Pigment	0.1	2.2	3.8	1.2	1.0	1.3	-1.7	-1.9	-1.4
Tanning	0.1	1.3	3.4	-0.1	1.8	-1.4	-1.1	-0.8	-1.0
Hand grip strength (left)	2.1	5.6	9.1	-2.2	3.0	0.9	-1.5	-3.0	-2.7
Number of treatments/medications taken	0.9	1.6	5.1	0.8	-0.3	1.7	0.8	2.2	-0.1
Average weekly spirits intake	1.3	1.6	4.0	-2.0	-0.0	1.5	1.2	1.3	-0.2
Sensitivity / hurt feelings	0.7	1.3	4.6	0.3	-0.4	-1.0	-0.2	-2.1	1.3
Frequency of depressed mood in last 2 weeks	0.2	0.3	1.0	-0.5	-1.0	-0.2	-0.1	-0.3	0.6
Hearing difficulty/problems: Yes	2.8	4.2	12.1	-1.0	3.5	-1.9	-2.6	-1.4	-0.3
Relative age of first facial hair	2.1	4.4	10.5	-0.5	2.0	-2.9	-3.2	-1.5	0.9
Other serious medical condition/disability diagnosed by doctor	1.1	1.4	4.5	0.5	-0.7	0.6	0.7	1.5	2.1
Ever used hormone-replacement therapy (HRT)	0.6	0.7	1.3	1.1	-1.1	-0.6	0.3	0.4	1.1
Ever had hysterectomy (womb removed)	1.5	1.6	7.3	0.4	-2.7	0.4	1.1	0.9	-0.5
Systolic blood pressure, automated reading	1.6	4.8	15.5	1.1	-0.9	3.9	1.3	3.0	0.6
Eye problems/disorders: Diabetes related eye disease	2.0	2.2	7.1	1.0	-0.6	2.7	1.7	1.2	0.2
Angina	0.6	0.8	1.6	1.3	1.0	-0.6	-0.7	0.3	1.2
Medication for hormone replacement therapy	0.6	0.7	2.0	0.3	1.1	-1.4	-1.0	0.1	-0.4
Vitamin and mineral supplements	1.5	2.0	5.4	2.3	-1.9	1.0	1.2	0.3	0.7
Supplements: Zinc	3.5	3.8	12.3	-3.5	1.8	-0.2	-1.7	-1.7	-1.2
Medication: Co-codamol	0.8	0.9	1.6	1.3	-0.7	1.3	-0.0	1.2	-0.7
Medication: Metformin	1.6	2.3	8.1	-0.4	-0.2	2.8	1.9	1.1	-0.7
Diabetes (father)	0.6	0.8	1.9	1.0	-1.4	1.0	0.8	0.4	0.3
Diabetes (mother)	0.1	0.2	0.7	-0.1	-0.2	-0.8	-0.0	0.4	0.1
Severe depression (siblings)	1.6	1.8	8.7	-0.3	0.8	-2.9	-0.7	0.9	0.6
Pack years adult smoking proportion	0.9	1.3	4.2	-0.5	-0.4	2.0	-0.9	0.6	-1.5
Impedance of leg (right)	2.5	12.2	41.9	3.9	2.4	-6.5	-3.1	-1.0	-0.3
Leg fat-free mass (left)	1.6	8.5	33.3	-3.4	-0.2	5.8	2.0	0.6	-1.5
Trunk fat percentage	0.9	3.8	10.2	-1.1	-0.9	3.2	1.9	2.5	0.7
Hand grip strength (right)	2.9	7.9	16.2	-2.7	4.0	0.0	-2.0	-3.8	-2.4
Townsend deprivation index at recruitment	6.2	8.7	15.3	0.9	-3.5	3.4	3.5	3.9	0.6
Current tobacco smoking	1.4	2.3	6.6	1.1	-2.6	1.2	0.9	1.9	-0.6
Average weekly fortified wine intake	0.7	0.8	3.0	0.7	1.7	0.4	0.3	0.1	0.9
Maternal smoking around birth	2.0	2.9	9.0	0.3	1.0	-0.1	-2.6	0.4	-3.0
Fed-up feelings	0.6	1.1	4.7	0.4	0.2	2.2	1.2	0.2	0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	1.5	1.2	-0.4	-0.0	-0.2	-0.9	0.2
Relative age voice broke	1.7	2.6	7.3	-0.8	1.1	-2.7	-2.0	-0.9	1.3
Taking other prescription medications	2.1	3.3	7.1	2.1	-1.5	2.0	1.0	2.7	-0.8
Age when periods started (menarche)	2.3	5.5	12.8	1.2	1.1	-3.6	-3.1	-2.6	-1.2
Bilateral oophorectomy (both ovaries removed)	1.5	1.7	2.8	1.2	-1.7	0.6	1.6	1.6	0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.4	4.7	0.9	-0.8	-0.6	-1.4	-0.2	-2.2
Tinnitus: Yes, but not now, but have in the past	2.7	2.9	6.8	0.4	-1.5	1.8	2.6	1.6	1.4
Qualifications: CSEs or equivalent	0.5	0.7	1.3	-0.4	1.1	1.1	0.0	1.1	0.5
Serious illness, injury or assault to yourself	0.3	0.4	0.8	0.3	-0.8	0.1	0.9	0.8	0.7
High blood pressure	0.3	0.8	3.4	-0.5	0.4	1.0	0.4	1.8	-0.0
Hayfever, allergic rhinitis or eczema	0.2	0.5	1.4	-0.1	1.2	-0.9	0.1	-0.6	0.7
Multivitamins +/- minerals	1.2	1.5	4.1	-1.4	2.0	-0.7	-1.2	0.9	-0.6
Stomach or abdominal pain in last month	0.4	0.5	1.8	-1.3	-0.9	-0.4	0.7	0.3	0.2
Supplements: Glucosamine	1.1	1.4	3.0	1.1	1.4	1.7	-0.1	-1.1	-1.2
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	1.1	-0.5	0.2	-0.7	-1.1	0.0	-0.7
Medication: Atenolol	1.2	1.5	4.0	0.1	2.0	-0.1	-1.5	-0.1	-1.6
Medication: Levothyroxine sodium	0.6	1.0	4.9	-0.6	0.2	-0.3	0.7	-2.2	0.6
Sitting height	0.7	4.9	12.1	-3.5	3.0	0.7	-0.5	-0.0	-2.8
Chronic bronchitis/emphysema (father)	1.0	1.2	2.9	0.0	1.0	0.5	0.6	-1.7	-1.7
High blood pressure (mother)	0.4	0.6	1.4	1.0	0.2	-1.2	0.2	0.2	1.1
Body mass index (BMI)	2.6	11.2	38.8	-2.2	-1.9	6.2	3.2	2.9	1.3
Impedance of leg (left)	2.3	11.1	39.9	3.4	2.1	-6.3	-3.2	-0.8	-0.4
Leg predicted mass (left)	1.6	8.6	33.2	-3.4	-0.2	5.8	2.0	0.6	-1.5
Trunk fat mass	1.3	5.6	20.1	-1.7	-0.6	4.5	2.0	2.4	-0.0
Waist circumference	1.9	6.8	21.5	-1.1	-1.6	4.6	2.5	2.9	1.0
Number of incorrect matches in round	0.8	1.3	3.3	-1.2	0.0	1.8	1.1	0.4	-1.3
Past tobacco smoking	0.4	0.7	1.6	-1.3	-0.9	-1.1	0.2	-0.5	0.4
Alcohol usually taken with meals	0.5	0.8	2.9	-0.7	0.7	-0.4	0.7	-1.7	0.6
Nervous feelings	1.4	2.5	6.9	-2.2	0.7	-0.9	-1.1	-2.6	-0.9
Frequency of tenseness / restlessness in last 2 weeks	1.2	1.8	3.7	-0.7	1.9	-0.1	-1.4	-1.9	-1.1
Hearing difficulty/problems with background noise	1.2	1.9	4.1	-1.7	2.0	-0.7	-1.4	-1.2	-0.9
Hair/balding pattern: Pattern 2	1.8	2.3	4.4	-1.7	-0.8	0.1	2.1	1.8	1.6
Had menopause	0.7	0.9	4.8	2.2	-0.2	0.3	0.0	-0.3	0.5
Had other major operations	2.1	2.6	6.4	0.0	-2.5	2.0	1.8	1.3	0.3
Forced vital capacity (FVC)	0.6	2.3	8.9	-1.1	1.9	-0.1	-0.3	0.3	-3.0
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.7	6.2	0.7	-1.8	0.6	-0.1	0.3	-2.5
Ever unenthusiastic/disinterested for a whole week	0.8	0.9	2.8	-1.7	-0.5	-1.0	0.2	0.7	1.0
Qualifications: None of the above	2.2	4.6	6.9	-0.6	-2.6	2.6	2.6	1.7	2.1
Financial difficulties in last 2 years	4.1	5.5	14.1	0.3	-3.8	0.5	3.2	0.1	2.9
Mouth/teeth dental problems	0.4	0.5	1.6	0.4	0.6	-1.2	0.8	0.1	0.8
Heart attack	0.4	0.5	1.0	0.4	0.4	-0.9	-0.9	-1.0	-0.5
Allergy	0.4	1.0	2.8	-1.0	0.7	-1.1	-1.7	0.1	-0.9
Pain all over the body in last month	0.9	0.9	2.1	1.4	0.6	0.8	0.6	-0.1	1.5
Diabetes (self-reported)	1.9	2.9	8.4	0.2	-1.2	2.9	1.7	2.2	-0.6
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	0.6	-0.1	0.6	-0.4	0.2	-0.8	0.2
Medication: Ramipril	0.3	0.4	0.8	-0.7	0.9	0.7	-0.5	0.1	-0.5
Medication: Simvastatin	0.6	0.8	3.6	-1.9	-0.8	-0.2	0.8	-0.4	0.0
Fluid intelligence score	3.4	7.0	15.3	0.7	2.6	-3.9	-3.3	-2.0	-2.2
Illnesses of siblings	0.4	0.5	1.1	-0.4	-0.9	-0.1	0.9	1.0	0.3
Neuroticism score	0.7	1.4	7.1	-0.8	0.1	0.6	0.1	-2.7	-0.4
Weight	1.8	8.8	34.1	-2.7	-0.6	5.8	2.6	1.9	-0.5
Impedance of arm (right)	2.6	12.0	50.4	2.8	2.6	-7.1	-2.5	-0.8	0.5
Arm fat percentage (right)	1.7	6.9	17.4	-1.1	-1.3	4.2	2.8	3.2	1.7
Trunk fat-free mass	1.2	7.1	29.1	-2.8	0.1	5.4	1.7	-0.2	-1.7
Hip circumference	1.3	5.8	20.4	-1.7	-0.7	4.5	2.4	2.0	0.9
Time employed in main current job	2.3	2.7	8.3	0.1	1.7	1.2	-0.8	-2.9	-1.6
Alcohol intake versus 10 years previously	3.3	4.9	12.5	0.3	-3.5	2.2	2.8	1.0	1.7
Father’s age at death	2.3	3.1	13.2	1.1	0.0	-1.4	-1.1	-3.6	-1.1
Worrier / anxious feelings	1.5	2.8	11.0	-1.2	0.3	-1.4	-1.3	-3.3	-0.8
Frequency of tiredness / lethargy in last 2 weeks	1.5	2.5	6.8	-0.6	-1.9	1.7	2.6	1.1	0.4
Falls in the last year	0.6	0.8	2.6	0.8	-1.0	0.5	1.6	-0.3	0.6
Hair/balding pattern: Pattern 3	0.9	1.4	4.1	0.6	0.6	-1.1	-1.4	-2.0	-0.3
Number of live births	1.0	1.5	4.5	-2.1	-1.2	0.8	1.1	0.6	0.9
Forced expiratory volume in 1-second (FEV1)	0.3	0.9	1.8	-1.3	1.3	-0.3	0.4	0.1	-1.3
Pulse rate	1.0	1.7	4.7	0.4	-0.5	1.0	1.8	1.0	2.2
Happiness	1.9	2.3	6.1	0.5	2.5	-0.7	-1.8	-0.7	-1.8
Noisy workplace	3.0	3.7	8.2	0.7	-1.3	2.9	2.6	2.2	0.5
Qualifications: A levels/AS levels or equivalent	1.8	4.1	6.7	-0.5	2.4	-2.4	-2.3	-2.6	-0.9
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	1.8	-1.1	-0.4	-0.4	0.3	-0.3	1.3
Mouth/teeth dental problems: Dentures	2.8	4.8	13.3	1.3	-0.1	1.6	-2.4	-2.3	-3.6
Asthma	1.2	2.4	5.0	0.8	-1.5	2.2	2.2	1.1	0.4
Medication: Ibuprofen (e.g. Nurofen)	1.3	1.7	3.7	-1.9	-1.0	-0.1	1.4	1.3	1.4
Medication: Cholesterol lowering	0.5	0.8	2.1	0.1	1.1	0.7	-0.8	0.4	-1.4
Depression (self-reported)	0.9	1.1	3.0	-1.7	0.1	-0.9	-1.2	-0.4	-0.9
Medication: Lansoprazole	2.3	2.6	6.7	2.0	0.4	1.5	-0.4	-1.4	-2.6
Prospective memory result	4.6	5.7	10.5	0.3	-2.9	2.5	2.6	3.2	1.5
Lung cancer (father)	1.7	1.9	4.2	-1.4	-1.1	2.0	1.7	1.1	-0.2
Illnesses of mother	0.5	0.7	2.0	-1.4	0.0	0.4	-0.4	-0.9	-1.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.0	2.4	-1.0	1.3	-0.7	-0.0	0.5	-1.5
Pulse wave Arterial Stiffness index	1.1	1.3	3.6	0.8	0.7	1.3	1.1	1.9	0.4
Impedance of arm (left)	2.1	9.6	40.8	2.9	2.0	-6.4	-1.9	-0.8	-0.0
Arm fat mass (right)	2.3	9.3	31.3	-2.0	-1.4	5.6	2.9	3.0	0.8
Trunk predicted mass	1.2	7.1	29.4	-2.6	0.1	5.4	1.7	-0.1	-1.7
Standing height	0.5	4.9	15.4	-1.5	2.8	0.1	-1.0	-1.9	-3.9
Length of working week for main job	1.4	1.5	3.3	0.5	-1.6	1.1	1.8	1.2	-0.5
Exposure to tobacco smoke at home	1.0	1.1	2.1	0.4	-1.3	0.7	1.4	1.2	0.8
Breastfed as a baby	0.8	1.0	2.7	0.9	1.1	-1.6	-1.1	0.0	-0.5
Tense / ‘highly strung’	1.6	2.7	6.7	-2.3	1.1	-0.5	-1.0	-2.6	-1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	1.5	2.2	4.5	-1.6	1.9	-2.1	-1.8	-0.0	-0.2
Hair/balding pattern: Pattern 4	0.1	0.3	0.7	0.2	-0.1	-0.1	-0.8	-0.8	-0.8
Birth weight of first child	0.8	1.4	4.8	-0.6	0.7	0.3	-0.8	1.3	-2.2
Peak expiratory flow (PEF)	0.5	1.0	3.0	-1.7	1.2	0.6	1.0	0.5	-0.4
Pulse wave reflection index	0.9	1.2	4.3	2.1	1.1	-0.2	-0.3	0.8	-0.8
Ever highly irritable/argumentative for 2 days	0.5	0.6	2.6	-1.6	0.1	-0.2	-0.4	-0.4	-0.6
Loud music exposure frequency	0.7	0.8	2.6	0.8	0.9	-1.6	-0.6	0.4	-0.4
Qualifications: O levels/GCSEs or equivalent	3.5	5.6	10.0	0.0	2.3	-2.9	-3.2	-2.9	-1.1
Mouth/teeth dental problems: Bleeding gums	3.1	4.0	7.8	-2.6	-1.3	1.2	2.3	0.9	2.8
Blood clot in the leg (DVT)	2.8	3.7	8.4	2.8	-2.9	0.0	2.2	0.3	1.0
Medication: Paracetamol	1.2	1.9	5.8	-2.4	-0.4	0.7	0.6	1.6	1.4
Headache pain in last month	1.5	2.6	6.9	-2.4	0.4	0.5	1.4	2.6	0.8
Medication for cholesterol, blood pressure or diabetes	0.4	0.6	1.4	-0.4	-0.6	-1.2	0.6	-0.7	1.0
Glaucoma (self-reported)	0.5	0.6	2.9	0.2	0.2	-0.8	0.3	-0.1	-1.7
Gout (self-reported)	0.8	1.1	3.2	0.1	-0.5	-1.4	-0.8	1.8	0.7
Hypothyroidism/myxoedema (self-reported)	0.3	0.7	2.1	-0.2	-0.5	-0.5	1.2	-1.5	0.1
Medication: Amlodipine	1.1	1.6	4.5	-0.2	-0.2	2.1	0.7	1.5	1.4
Medication: Ventolin 100micrograms inhaler	1.0	1.3	2.7	-0.4	-1.6	0.9	1.4	0.7	1.3
Birth weight	0.6	1.3	2.9	-1.7	0.4	0.4	-0.7	-1.3	-1.7
Chronic bronchitis/emphysema (mother)	0.4	0.4	1.2	1.1	0.6	-0.2	-0.7	-0.0	0.7
High blood pressure (siblings)	1.0	1.4	2.8	0.0	1.6	-0.9	-1.7	-1.3	-0.8
Forced vital capacity (FVC), Best measure	0.6	2.3	8.0	-1.2	1.9	-0.1	-0.1	1.0	-2.8
Body fat percentage	1.2	4.7	14.2	-0.9	-1.0	3.8	2.1	2.7	0.9
Leg fat percentage (right)	1.2	4.3	17.0	-0.4	-0.3	4.1	1.5	2.4	0.9
Arm fat-free mass (right)	1.8	9.4	35.8	-3.4	-0.9	6.0	2.2	0.6	-1.7
Exposure to tobacco smoke outside home	1.8	2.4	5.7	-0.9	-2.4	1.1	1.7	1.3	1.3
Comparative body size at age 10	1.1	3.1	10.6	-2.3	0.4	3.3	-0.0	0.1	-1.6
Number of full brothers	1.0	1.3	3.7	1.2	-0.8	0.4	-0.5	-1.1	-1.9
Worry too long after embarrassment	1.1	1.8	7.9	-0.3	-1.2	-1.1	0.4	-2.8	0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	4.2	-2.0	-0.4	-0.7	-0.0	0.1	0.7
Wheeze or whistling in the chest in last year	0.2	0.4	1.4	0.1	1.2	0.8	-0.2	-0.6	0.4
Number of children fathered	0.6	0.6	1.3	-0.3	0.7	0.7	-0.7	-1.1	-1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	2.2	-0.0	0.4	-1.5	-0.4	-1.0	0.1
Age at first live birth	1.2	2.1	3.4	1.6	1.8	-1.4	-1.8	-0.7	-0.7
Pulse wave peak to peak time	1.1	1.3	3.2	-1.0	-0.5	-1.2	-1.1	-1.8	-0.7
Health satisfaction	1.4	1.8	3.3	-1.7	-1.2	0.0	1.1	1.3	1.8
Shortness of breath walking on level ground	0.6	0.7	1.9	-0.0	-0.6	0.4	1.3	0.2	1.4
Qualifications: College or University degree	1.3	4.1	9.6	-0.7	3.1	-1.7	-1.3	-1.8	-2.6
Eye problems/disorders: None of the above	1.9	2.2	7.4	0.7	0.0	-2.7	-0.7	1.5	1.5
Mouth/teeth dental problems: Loose teeth	0.3	0.4	1.0	-0.6	-0.3	1.0	0.5	0.2	-0.7
Emphysema/chronic bronchitis	2.1	2.4	4.4	1.2	-2.1	1.9	1.3	0.5	1.7
Medication for pain relief, constipation, heartburn	0.8	1.4	4.1	2.0	1.5	-0.7	-0.2	-1.2	-0.3
Neck or shoulder pain in last month	1.4	1.9	4.4	-0.3	-1.8	-0.2	0.8	1.8	2.1
Medication: Blood pressure	0.6	1.1	3.7	1.3	-0.4	1.9	0.2	-0.3	-1.1
Angina (self-reported)	0.4	0.6	0.8	0.8	0.9	-0.6	-0.9	0.1	0.9
Migraine (self-reported)	2.7	3.4	7.2	-2.7	0.8	-2.1	-0.5	2.3	1.6
Medication: Ibuprofen	1.1	1.4	2.9	-1.7	-0.6	0.1	1.4	1.1	1.3
Medication: Allopurinol	0.8	1.1	4.2	0.2	-1.4	0.0	0.4	2.1	0.6
Medication: Omeprazole	0.5	0.6	0.9	0.7	-0.6	0.9	-0.2	-1.0	-0.8
Medication: Seretide 50 evohaler	0.6	0.7	3.0	-0.0	1.0	0.1	0.4	1.7	0.4
Mean time to correctly identify matches	0.9	1.6	3.9	1.0	1.0	-1.7	-2.0	-0.5	-0.8
Heart disease (mother)	1.2	1.4	2.7	-1.6	1.2	-1.6	-1.0	0.6	0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.4	1.8	-0.5	1.4	-0.2	-0.2	-0.3	0.6
Whole body fat mass	1.8	7.4	28.4	-1.7	-0.9	5.3	2.4	2.6	0.1
Leg fat mass (right)	1.7	6.6	27.3	-1.8	-0.3	5.2	2.0	2.2	-0.0
Arm predicted mass (right)	1.8	9.1	35.4	-3.2	-0.9	5.9	2.1	0.5	-1.8
Pulse rate, automated reading	0.4	1.2	2.7	1.1	-0.0	1.2	0.6	1.2	1.6
Alcohol intake frequency.	4.0	9.4	20.5	0.6	-4.5	1.6	4.1	0.5	4.0
Comparative height size at age 10	0.3	1.7	5.9	0.5	-0.6	1.9	0.5	-0.4	-2.4
Number of full sisters	1.8	2.2	9.9	0.6	1.1	-3.1	-1.4	0.3	-0.3
Suffer from ‘nerves’	1.3	2.0	3.0	-1.7	1.7	-1.5	-1.5	-1.2	-0.4
Overall health rating	1.2	2.6	5.2	-2.3	-1.0	2.1	1.3	1.9	0.2
Chest pain or discomfort	0.6	0.9	2.1	-1.4	0.8	0.7	0.1	-1.0	1.0
Had major operations	0.4	0.5	1.4	1.2	-0.5	0.7	-0.0	0.5	-0.8
Age at last live birth	0.3	0.5	1.6	1.3	0.3	-0.7	-0.2	-0.2	0.8
Family relationship satisfaction	1.4	1.7	3.5	0.1	1.6	-1.9	-1.6	0.5	-1.2
Leg pain on walking	0.9	1.1	3.4	-0.5	-1.8	0.1	1.2	1.0	0.9
Qualifications: NVQ or HND or HNC or equivalent	1.8	2.1	6.8	0.6	-0.9	1.0	1.6	1.0	2.6
Commuting to job workplace: Car/motor vehicle	0.3	0.4	0.9	0.6	1.0	0.0	-0.8	-0.2	0.5
Illness, injury, bereavement, stress in last 2 years	1.6	1.9	4.2	-0.3	1.8	1.6	-0.8	0.9	-2.0
Medication: Aspirin	0.9	1.2	2.6	0.1	-0.2	-0.9	-1.6	-1.4	-1.3
Supplements: Vitamin C	0.4	0.5	1.1	-0.9	0.8	-0.4	-0.3	-1.1	-0.1
Knee pain experienced in last month	1.4	2.2	7.7	-1.3	-1.1	2.8	1.5	0.2	0.1
Hypertension (Self-reported)	0.2	0.7	3.1	-0.5	0.5	0.5	0.3	1.8	0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.9	2.3	5.5	2.3	-0.3	1.5	-0.3	-1.9	-1.4
Illnesses of father: Heart disease	1.9	2.6	6.0	-2.4	1.8	-1.9	-1.5	-0.4	0.3
Illnesses of siblings: Diabetes	2.0	2.4	5.7	0.9	-2.4	1.3	1.4	2.0	0.5
Smoking status: Previous	0.5	0.7	2.3	0.6	1.5	0.9	-0.7	0.5	0.0
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.9	2.1	-1.2	0.3	0.4	0.3	1.5	-1.2
Whole body fat-free mass	1.5	8.8	35.0	-3.3	-0.3	5.9	2.0	0.1	-1.7
Leg fat-free mass (right)	1.8	9.5	35.3	-3.8	-0.6	5.9	2.2	0.6	-1.5
Arm fat percentage (left)	1.8	7.1	18.6	-1.0	-1.6	4.3	2.9	3.2	1.4
Average weekly red wine intake	1.2	1.7	2.7	-0.3	1.6	-1.5	-1.3	-1.0	-1.6
Handedness (chirality/laterality): Left-handed	0.7	0.8	1.5	-0.1	0.7	-1.0	-0.7	1.1	-1.2
Mood swings	0.1	0.3	1.1	-0.0	1.1	0.5	0.3	-0.3	0.3
Loneliness, isolation	0.3	0.4	1.8	1.4	0.7	0.1	-0.3	0.0	0.0
Long-standing illness, disability or infirmity	2.9	4.5	6.9	-0.5	-2.6	2.0	2.2	2.2	2.4
Ever had bowel cancer screening	0.1	0.1	0.4	0.6	-0.4	-0.4	-0.4	-0.1	0.0
Diabetes diagnosed by doctor	1.6	2.7	7.8	0.4	-1.0	2.8	1.7	2.0	-0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.9	-0.3	-0.5	-0.9	-0.7	0.1	-0.2
Friendships satisfaction	5.2	6.4	12.9	1.0	2.9	-3.3	-3.6	-1.1	-1.9
Qualifications: nursing, teaching	1.6	2.5	3.6	-0.2	1.9	-1.9	-1.8	-1.4	-1.5
Commuting to job workplace: Walk	0.2	0.2	0.5	-0.7	0.4	-0.7	0.1	-0.5	0.2
Eye problems/disorders: Cataract	0.9	1.0	2.5	0.2	-0.1	1.6	1.3	-1.3	0.4
Mouth/teeth dental problems: Mouth ulcers	0.7	1.2	4.4	0.5	0.1	-0.9	-0.2	2.1	1.2
Medication for cholesterol	0.3	0.5	0.8	0.8	-0.9	0.9	0.4	-0.6	0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.3	1.5	5.1	-0.9	0.1	1.6	-0.4	0.7	-2.2
Back pain experienced in last month	1.6	2.3	4.0	-1.7	-2.0	1.4	1.0	0.8	1.8
Mineral and other dietary supplements	1.6	2.2	5.9	0.6	-1.4	-1.6	0.3	1.4	2.4
Breast cancer (self-reported)	1.6	1.9	4.0	-1.0	-1.9	2.0	1.1	1.1	-0.0
Asthma (self-reported)	1.2	2.5	5.3	0.8	-1.4	2.3	2.3	1.2	0.6
Osteoporosis (self-reported)	2.9	3.6	6.8	2.1	0.6	-2.3	-2.6	-2.1	0.6
Osteoarthritis (self-reported)	1.6	2.1	6.7	0.9	-1.4	2.6	0.3	-0.4	-1.7
Medication: Aspirin	1.1	1.4	3.6	0.4	-0.2	-1.1	-1.9	-1.1	-1.5
Medication: Gliclazide	0.3	0.3	1.0	0.6	-0.1	0.2	-0.5	0.4	-1.0
Illnesses of father: None of the above (group 1)	0.4	0.5	1.4	0.2	-0.9	1.2	0.6	0.1	0.4
Smoking status: Current	1.6	2.6	6.9	1.6	-2.6	1.3	1.2	1.6	-0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	2.7	-0.5	0.8	-0.6	-0.1	-0.8	-1.6
Whole body water mass	1.6	8.9	35.4	-3.3	-0.4	6.0	2.1	0.4	-1.6
Leg predicted mass (right)	1.8	9.6	35.6	-3.7	-0.5	6.0	2.1	0.6	-1.6
Arm fat mass (left)	2.0	8.2	29.5	-2.0	-1.2	5.4	2.8	2.5	0.4
Number of self-reported non-cancer illnesses	1.6	2.8	10.0	-0.0	-1.8	0.7	1.5	3.2	0.9
Average weekly champagne plus white wine intake	1.6	2.3	12.0	-0.8	-0.3	-0.0	-0.5	-3.5	-0.8
Miserableness	0.5	0.9	2.2	1.5	0.3	0.8	0.5	-1.4	-0.1
Guilty feelings	0.3	0.4	1.1	-0.6	1.1	0.6	0.1	-0.7	-0.3
Wears glasses or contact lenses	0.7	0.8	3.7	0.2	-0.3	1.9	0.8	-0.1	0.0
Ever taken oral contraceptive pill	0.5	0.6	1.8	1.3	0.7	-0.6	-0.5	-0.1	-0.6
Hearing aid user	0.4	0.4	1.6	0.4	0.3	-0.7	-0.4	1.3	0.0
Mother’s age at death	1.5	1.9	4.5	0.1	1.1	-2.1	-1.4	-1.9	-0.2
Financial situation satisfaction	2.2	2.7	5.2	-0.0	-2.1	1.0	2.0	1.3	2.3
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.8	1.0	0.8	-1.0	-1.4	0.2	0.0
Commuting to job workplace: Public transport	0.2	0.2	0.5	-0.7	-0.5	0.5	0.5	0.4	-0.3
Eye problems/disorders: Glaucoma	0.6	0.7	3.9	-0.2	0.5	0.1	0.2	-0.1	-2.0
Medication: Blood pressure	0.4	0.8	2.9	-0.7	1.7	-0.2	-0.4	0.7	0.9
Pain type(s) experienced in last month: Hip pain	0.7	0.9	2.5	-0.5	-0.6	1.1	0.2	1.6	-1.1
Supplements: Fish oil (including cod liver oil)	1.3	1.6	4.0	-1.1	1.2	1.7	0.1	0.1	-2.0
High cholesterol (Self-reported)	0.1	0.1	0.3	0.5	0.2	-0.5	-0.4	0.1	-0.1
Medication: Bendroflumethiazide	0.2	0.3	0.7	-0.8	0.8	0.5	0.1	0.1	-0.2
Medication: Paracetamol	1.1	1.7	6.7	-2.6	0.2	1.0	0.5	1.0	1.2
Medication: Lisinopril	1.5	1.9	4.8	0.7	-2.2	1.9	1.5	0.3	-0.2
Medication: Atorvastatin	0.9	1.1	2.6	1.5	0.3	1.2	0.3	1.6	-0.2
Illnesses of father: High blood pressure	0.2	0.2	0.5	0.4	0.0	-0.7	0.1	0.7	0.2
Alcohol drinker status: Never	2.9	3.5	8.7	0.5	-3.0	-0.9	2.2	0.5	2.5
Ever smoked	0.2	0.3	0.9	0.8	0.4	0.4	-0.1	0.5	-0.9
Basal metabolic rate	1.7	9.3	36.8	-3.4	-0.5	6.1	2.3	0.7	-1.4
Leg fat percentage (left)	1.4	5.0	19.9	-0.6	-0.5	4.5	1.6	2.6	0.8
Arm fat-free mass (left)	1.8	9.1	35.4	-3.5	-0.7	5.9	2.0	0.7	-1.3
Number of operations (self-reported)	3.8	5.7	11.8	0.8	-3.4	2.5	2.0	3.3	-0.7
Average weekly beer plus cider intake	2.1	3.0	5.1	-0.9	1.9	0.4	-1.9	2.3	-2.2
Irritability	1.5	2.5	7.0	-1.1	-0.3	1.0	-0.4	-2.4	-2.6
Risk taking	0.5	0.7	1.5	0.8	-0.2	-0.7	-0.8	-1.2	-1.0
Ever had prostate specific antigen (PSA) test	0.2	0.3	0.7	0.2	0.1	-0.7	-0.5	0.8	-0.0
Fractured/broken bones in last 5 years	0.6	0.8	3.6	-0.1	0.0	-0.9	0.3	0.6	1.9
Age started oral contraceptive pill	1.3	1.6	6.7	2.6	-0.3	-0.9	-0.3	-1.3	0.4
Diastolic blood pressure, automated reading	0.3	1.0	2.6	1.3	1.1	-0.4	-1.6	-0.5	0.2
Ever depressed for a whole week	3.0	3.7	8.0	-2.8	0.8	-2.7	-0.1	1.3	2.1
Unable to work because of sickness or disability	1.2	1.5	4.9	1.1	-0.8	2.2	0.7	1.3	-0.1
Commuting to job workplace: Cycle	1.7	2.1	4.1	0.6	1.8	-2.0	-1.4	-1.5	-0.8
Myopia	0.5	0.8	3.2	0.2	-0.3	-1.8	-1.1	-0.3	0.5
Vascular/heart problems diagnosed by doctor	0.3	0.9	3.1	0.1	-0.1	-1.3	-0.6	-1.8	-0.4
Cholesterol lowering medication	0.6	0.9	2.3	-0.8	-1.5	0.1	1.4	0.4	0.7
Medication: Omeprazole (e.g. Zanprol)	0.7	0.9	1.9	0.9	-0.4	0.4	-0.7	-1.4	-1.4
Pain experienced in last month	0.9	1.5	5.5	2.4	0.3	-1.1	-0.7	-1.1	-0.9
Supplements: Calcium	1.7	1.9	8.2	-0.4	1.0	-0.5	-1.2	-2.9	0.1
Basal cell carcinoma (self-reported)	0.4	0.4	1.8	-0.0	-0.0	1.3	0.1	-0.2	-0.9
Heart attack/myocardial infarction (self-reported)	0.5	0.6	1.1	0.3	0.8	-0.8	-1.0	-0.9	-0.7
Deep venous thrombosis (DVT) (self-reported)	2.8	3.6	7.7	2.6	-2.8	0.3	2.4	0.3	1.0
Heart disease (siblings)	0.5	0.6	2.1	-0.6	0.8	-0.7	-0.0	-0.1	1.4
Alcohol drinker status: Previous	1.1	1.2	2.9	1.5	-0.7	1.7	0.6	1.1	0.2
Pack years of smoking	0.8	1.2	4.0	-0.1	-0.4	2.0	-1.1	0.2	-1.3
Impedance of whole body	2.4	12.0	49.7	2.8	2.2	-7.0	-2.9	-0.9	-0.1
Leg fat mass (left)	1.8	6.9	29.7	-1.7	-0.4	5.4	2.0	2.2	-0.2
Arm predicted mass (left)	1.9	9.6	37.9	-3.6	-0.5	6.2	1.9	0.5	-1.6