TWAS
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Traits
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Leg fat mass (left)
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chr19:46,923,752-48,406,374
Best TWAS P=3.07e-08 · Best GWAS P=1.69e-22 conditioned to 5.69e-18
47M
47.2M
47.4M
47.6M
47.8M
48M
48.2M
48.4M
0
5
10
15
20
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
GTEx
Cells EBV-transformed lymphocytes
SAE1
0.21
0.09
lasso
3
0.07
2.0e-03
-3.5
-5.5
3.1e-08
0.77
0.06
0.67
TRUE
2
METSIM
Adipose
SAE1
0.12
0.04
lasso
5
0.07
1.7e-10
-4.0
-5.1
3.1e-07
0.61
0.61
0.39
FALSE