Best TWAS P=2.7e-11 · Best GWAS P=1.82e-10 conditioned to 0.0858
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | YFS | Blood | AP3B1 | 0.25 | 0.22 | lasso | 9 | 0.23 | 2.6e-74 | 5.2 | -5.4 | 5.4e-08 | 0.31 | 0.77 | 0.23 | FALSE |
| 2 | The Cancer Genome Atlas | Breast Invasive Carcinoma | AP3B1 | 0.02 | 0.00 | blup | 126 | 0.01 | 1.8e-02 | -6.2 | -6.4 | 1.3e-10 | 0.86 | 0.02 | 0.90 | FALSE |
| 3 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | AP3B1 | 0.16 | 0.06 | enet | 18 | 0.09 | 2.2e-05 | 5.5 | -5.3 | 1.0e-07 | 0.53 | 0.04 | 0.56 | FALSE |
| 4 | The Cancer Genome Atlas | Prostate Adenocarcinoma | AP3B1 | 0.05 | 0.02 | blup | 126 | 0.03 | 5.0e-04 | 5.4 | -6.7 | 2.7e-11 | 0.80 | 0.02 | 0.91 | TRUE |