[Hub]/) : Traits : Leg fat mass (left) :

chr5:73,626,450-75,704,085

Best TWAS P=1.86e-29 · Best GWAS P=1.81e-31 conditioned to NaN

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex ANKRD31 0.10 0.13 lasso 9 0.13 3.9e-15 -8.0 7.5 6.6e-14 -0.33 1.00 0.00 FALSE
2 CommonMind Brain Pre-frontal Cortex POC5 0.17 0.16 lasso 5 0.15 5.2e-18 -11.1 11.3 1.9e-29 -0.90 0.21 0.79 TRUE
3 GTEx Adipose Subcutaneous POC5 0.08 0.07 lasso 7 0.07 3.2e-06 -7.4 -7.5 7.8e-14 0.56 0.96 0.00 TRUE
4 GTEx Adipose Visceral Omentum POC5 0.13 0.08 lasso 9 0.08 6.1e-05 -7.3 -7.4 1.0e-13 0.60 0.82 0.07 FALSE
5 GTEx Adrenal Gland GCNT4 0.13 0.02 lasso 8 0.01 1.3e-01 -7.6 -9.4 8.1e-21 0.49 0.18 0.52 TRUE
6 GTEx Artery Tibial GCNT4 0.08 0.07 lasso 2 0.04 3.9e-04 -7.6 7.7 1.2e-14 -0.44 0.56 0.24 TRUE
7 GTEx Brain Cerebellar Hemisphere POLK 0.27 0.20 lasso 6 0.16 8.3e-05 -8.0 -9.3 1.4e-20 0.64 0.35 0.15 TRUE
8 GTEx Brain Cerebellar Hemisphere POC5 0.31 0.15 enet 18 0.30 1.6e-08 -7.4 -9.2 5.2e-20 0.61 0.60 0.24 FALSE
9 GTEx Brain Hypothalamus CTC-366B18.4 0.26 0.12 lasso 8 0.07 9.0e-03 -7.4 7.5 4.9e-14 -0.56 0.10 0.09 FALSE
10 GTEx Cells EBV-transformed lymphocytes POC5 0.47 0.36 lasso 4 0.39 1.3e-13 -7.4 -7.4 1.4e-13 0.57 1.00 0.00 FALSE
11 GTEx Cells Transformed fibroblasts POLK 0.06 0.04 lasso 3 0.04 1.0e-03 -8.0 8.4 4.4e-17 -0.61 0.24 0.47 FALSE
12 GTEx Cells Transformed fibroblasts POC5 0.15 0.17 lasso 6 0.16 3.4e-12 -7.3 -7.3 2.4e-13 0.57 1.00 0.00 FALSE
13 GTEx Colon Transverse POC5 0.23 0.16 lasso 4 0.18 6.0e-09 -7.3 -5.5 3.9e-08 0.39 0.96 0.00 FALSE
14 GTEx Esophagus Mucosa COL4A3BP 0.09 0.06 lasso 5 0.05 4.2e-04 -5.0 6.8 1.1e-11 -0.51 0.78 0.06 FALSE
15 GTEx Esophagus Mucosa POC5 0.18 0.16 lasso 1 0.15 4.8e-10 -7.3 -7.3 2.4e-13 0.57 1.00 0.00 FALSE
16 GTEx Nerve Tibial POC5 0.16 0.12 lasso 5 0.10 7.6e-08 -7.3 -7.3 2.6e-13 0.57 0.99 0.00 FALSE
17 GTEx Pancreas POC5 0.32 0.23 lasso 3 0.21 3.5e-09 -7.3 -7.5 9.6e-14 0.57 1.00 0.00 FALSE
18 GTEx Spleen POLK 0.18 -0.01 lasso 16 0.03 5.1e-02 -4.9 -9.8 8.9e-23 0.59 0.17 0.20 FALSE
19 GTEx Spleen POC5 0.42 0.37 lasso 4 0.34 1.3e-09 -7.4 -7.6 3.6e-14 0.57 0.94 0.03 FALSE
20 GTEx Spleen CTC-366B18.2 0.16 0.11 lasso 3 0.14 2.2e-04 -7.4 -9.4 6.1e-21 0.72 0.17 0.38 FALSE
21 GTEx Stomach POC5 0.10 0.06 enet 12 0.08 8.3e-05 -8.0 -5.9 2.8e-09 0.43 0.56 0.02 TRUE
22 GTEx Testis POC5 0.27 0.13 lasso 8 0.09 8.1e-05 -8.3 7.7 1.5e-14 -0.65 0.58 0.21 FALSE
23 GTEx Testis GCNT4 0.42 0.35 enet 62 0.37 3.8e-17 -7.9 -9.1 6.5e-20 0.50 1.00 0.00 FALSE
24 GTEx Thyroid POC5 0.26 0.23 enet 15 0.23 1.8e-17 -7.3 -6.3 3.0e-10 0.49 1.00 0.00 FALSE
25 GTEx Thyroid CTC-366B18.2 0.06 0.03 lasso 9 0.02 6.2e-03 -8.8 -8.8 1.5e-18 0.62 0.31 0.15 FALSE
26 METSIM Adipose POC5 0.11 0.09 enet 29 0.10 7.5e-15 -7.3 -6.2 4.6e-10 0.48 1.00 0.00 FALSE
27 METSIM Adipose POLK 0.05 0.01 enet 16 0.03 4.3e-05 -9.2 -10.0 1.9e-23 0.58 0.96 0.02 FALSE
28 ROSMAP Brain Pre-frontal Cortex POLK 0.03 0.01 lasso 7 0.02 3.9e-03 -9.0 -10.3 5.9e-25 0.81 0.27 0.63 FALSE
29 ROSMAP Brain Pre-frontal Cortex POC5 0.05 0.00 blup 384 0.02 8.6e-04 -7.3 -8.1 7.2e-16 0.57 0.30 0.13 FALSE
30 ROSMAP Brain Pre-frontal Cortex ANKDD1B 0.07 0.00 bslmm 382 0.03 7.0e-05 -5.6 8.8 1.6e-18 -0.63 0.08 0.54 FALSE
31 The Cancer Genome Atlas Colon Adenocarcinoma GCNT4 0.10 0.06 enet 6 0.05 8.7e-04 -4.2 7.0 2.5e-12 -0.41 0.08 0.55 TRUE
32 The Cancer Genome Atlas Brain Lower Grade Glioma POC5 0.04 0.00 enet 7 0.03 2.1e-04 -11.1 8.7 2.8e-18 -0.77 0.02 0.57 FALSE
33 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma HMGCR 0.04 0.02 enet 4 0.03 6.0e-03 -7.8 -7.9 2.2e-15 0.57 0.03 0.50 TRUE
34 The Cancer Genome Atlas Prostate Adenocarcinoma POLK 0.03 0.01 blup 53 0.01 1.6e-02 -5.9 8.0 9.4e-16 -0.57 0.28 0.49 TRUE
35 The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma POC5 0.24 0.13 blup 70 0.14 1.2e-04 -8.4 -7.9 2.4e-15 0.73 0.05 0.80 TRUE