Best TWAS P=1.13e-10 · Best GWAS P=5.94e-12 conditioned to 0.0115
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | RANBP17 | 0.10 | 0.14 | lasso | 3 | 0.13 | 1.4e-15 | -5.6 | 5.8 | 5.8e-09 | -0.92 | 0.27 | 0.73 | FALSE |
| 2 | GTEx | Brain Caudate basal ganglia | RANBP17 | 0.26 | 0.19 | lasso | 5 | 0.14 | 9.7e-05 | -5.6 | 5.7 | 9.8e-09 | -0.87 | 0.29 | 0.58 | FALSE |
| 3 | GTEx | Brain Cerebellar Hemisphere | RANBP17 | 0.20 | 0.04 | lasso | 5 | 0.05 | 1.6e-02 | -5.6 | 6.0 | 1.8e-09 | -0.89 | 0.06 | 0.80 | FALSE |
| 4 | GTEx | Esophagus Muscularis | RANBP17 | 0.12 | 0.02 | lasso | 2 | 0.02 | 3.5e-02 | -5.7 | 5.5 | 4.6e-08 | -0.89 | 0.13 | 0.78 | FALSE |
| 5 | GTEx | Uterus | NPM1 | 0.31 | 0.17 | lasso | 9 | 0.09 | 7.4e-03 | -5.6 | 5.7 | 1.2e-08 | -0.90 | 0.12 | 0.32 | FALSE |
| 6 | The Cancer Genome Atlas | Breast Invasive Carcinoma | RANBP17 | 0.02 | 0.00 | blup | 135 | 0.01 | 3.7e-04 | -6.8 | 6.5 | 1.1e-10 | -0.88 | 0.02 | 0.92 | TRUE |
| 7 | The Cancer Genome Atlas | Prostate Adenocarcinoma | RANBP17 | 0.03 | 0.06 | lasso | 4 | 0.05 | 8.1e-06 | -5.7 | 5.7 | 1.2e-08 | -0.89 | 0.22 | 0.77 | FALSE |