[Hub]/) : Traits : Leg fat mass (left) :

chr6:25,035,920-26,689,223

Best TWAS P=2.76e-24 · Best GWAS P=1.35e-30 conditioned to 1.19e-16

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Subcutaneous U91328.19 0.40 0.46 lasso 8 0.46 4.2e-41 -7.5 7.4 1.1e-13 -0.31 1.00 0.00 FALSE
2 GTEx Adipose Visceral Omentum U91328.19 0.21 0.25 lasso 8 0.27 3.7e-14 -7.5 8.0 1.9e-15 -0.32 1.00 0.00 FALSE
3 GTEx Adrenal Gland U91328.19 0.28 0.12 lasso 10 0.14 1.3e-05 -7.1 9.1 8.5e-20 -0.34 0.95 0.00 FALSE
4 GTEx Artery Aorta U91328.19 0.32 0.24 lasso 7 0.25 8.3e-14 -8.2 8.6 1.0e-17 -0.35 1.00 0.00 FALSE
5 GTEx Artery Coronary U91328.19 0.32 0.16 enet 44 0.23 3.7e-08 -7.5 5.6 1.9e-08 -0.06 0.79 0.01 FALSE
6 GTEx Artery Tibial U91328.19 0.26 0.32 lasso 5 0.31 1.6e-24 -7.5 7.8 5.9e-15 -0.33 1.00 0.00 FALSE
7 GTEx Brain Caudate basal ganglia U91328.19 0.23 0.16 lasso 10 0.16 3.1e-05 -7.3 7.7 1.2e-14 -0.25 0.72 0.03 FALSE
8 GTEx Brain Cerebellar Hemisphere U91328.19 0.47 0.33 enet 44 0.26 2.8e-07 -7.0 8.4 4.1e-17 -0.37 0.98 0.00 FALSE
9 GTEx Brain Cerebellum U91328.19 0.13 0.15 lasso 2 0.09 1.1e-03 -7.0 6.9 6.8e-12 -0.33 0.36 0.04 FALSE
10 GTEx Brain Cortex U91328.19 0.36 0.14 lasso 10 0.15 7.1e-05 -7.6 8.2 1.8e-16 -0.31 0.64 0.03 FALSE
11 GTEx Brain Frontal Cortex BA9 U91328.19 0.17 0.16 lasso 4 0.18 1.8e-05 -7.6 7.8 5.1e-15 -0.32 0.45 0.04 FALSE
12 GTEx Breast Mammary Tissue U91328.19 0.38 0.39 lasso 5 0.38 2.2e-20 -7.5 7.7 1.1e-14 -0.32 1.00 0.00 FALSE
13 GTEx Breast Mammary Tissue (Male) U91328.19 0.35 0.15 enet 25 0.15 2.9e-04 -7.5 6.5 1.1e-10 -0.33 0.38 0.04 FALSE
14 GTEx Breast Mammary Tissue (Female) U91328.19 0.39 0.27 lasso 6 0.23 1.4e-07 -7.5 7.9 2.9e-15 -0.35 0.95 0.00 FALSE
15 GTEx Cells Transformed fibroblasts U91328.19 0.58 0.62 lasso 8 0.60 6.2e-56 -7.5 7.5 8.4e-14 -0.32 1.00 0.00 FALSE
16 GTEx Esophagus Gastroesophageal Junction U91328.20 0.16 0.13 enet 16 0.13 2.0e-05 -5.3 6.4 1.7e-10 -0.34 0.44 0.06 FALSE
17 GTEx Esophagus Gastroesophageal Junction U91328.19 0.28 0.07 lasso 7 0.21 4.3e-08 -7.6 7.0 2.5e-12 -0.33 0.71 0.02 FALSE
18 GTEx Esophagus Mucosa U91328.19 0.45 0.42 lasso 7 0.44 6.3e-32 -7.5 8.2 2.2e-16 -0.35 1.00 0.00 FALSE
19 GTEx Esophagus Muscularis TRIM38 0.06 0.04 lasso 4 0.02 1.7e-02 -8.2 7.1 9.7e-13 -0.36 0.53 0.03 FALSE
20 GTEx Esophagus Muscularis U91328.19 0.36 0.30 lasso 10 0.30 1.7e-18 -8.2 8.1 4.0e-16 -0.34 1.00 0.00 FALSE
21 GTEx Heart Atrial Appendage U91328.19 0.25 0.17 enet 6 0.13 2.0e-06 -7.5 7.9 2.6e-15 -0.32 0.99 0.00 FALSE
22 GTEx Heart Left Ventricle U91328.19 0.20 0.18 lasso 5 0.15 2.4e-08 -7.5 7.4 1.6e-13 -0.32 0.99 0.00 FALSE
23 GTEx Liver U91328.19 0.16 0.14 lasso 2 0.05 1.9e-02 -6.2 6.2 6.6e-10 -0.39 0.26 0.17 FALSE
24 GTEx Lung U91328.19 0.20 0.22 enet 15 0.24 2.9e-18 -8.4 8.6 1.0e-17 -0.34 1.00 0.00 FALSE
25 GTEx Muscle Skeletal U91328.19 0.28 0.26 enet 15 0.32 1.3e-31 -7.5 7.5 4.6e-14 -0.29 1.00 0.00 FALSE
26 GTEx Nerve Tibial U91328.19 0.46 0.38 lasso 10 0.36 1.4e-26 -7.5 7.6 2.7e-14 -0.32 1.00 0.00 FALSE
27 GTEx Ovary U91328.19 0.37 0.17 enet 18 0.34 4.7e-09 -7.6 10.2 2.8e-24 -0.41 0.74 0.03 TRUE
28 GTEx Prostate U91328.19 0.30 0.39 lasso 2 0.37 3.0e-10 -7.5 7.5 5.2e-14 -0.32 0.96 0.01 FALSE
29 GTEx Skin Not Sun Exposed Suprapubic U91328.19 0.39 0.37 lasso 11 0.34 2.4e-19 -7.5 8.1 8.0e-16 -0.35 1.00 0.00 FALSE
30 GTEx Skin Sun Exposed Lower leg TRIM38 0.09 0.00 enet 21 0.02 6.3e-03 -2.4 -5.4 5.8e-08 0.03 0.33 0.03 FALSE
31 GTEx Skin Sun Exposed Lower leg U91328.19 0.29 0.34 lasso 6 0.34 5.6e-29 -7.5 7.8 4.3e-15 -0.34 1.00 0.00 FALSE
32 GTEx Stomach U91328.19 0.17 0.05 lasso 5 0.05 1.7e-03 -7.5 6.4 1.4e-10 -0.24 0.56 0.06 FALSE
33 GTEx Thyroid TRIM38 0.14 0.16 lasso 4 0.17 8.5e-13 -5.9 5.8 6.3e-09 -0.23 1.00 0.00 FALSE
34 GTEx Thyroid U91328.19 0.21 0.17 lasso 5 0.17 6.4e-13 -7.5 7.0 2.2e-12 -0.31 1.00 0.00 FALSE
35 GTEx Thyroid U91328.21 0.08 0.04 lasso 3 0.05 5.5e-05 -5.9 5.6 2.6e-08 -0.25 0.74 0.01 FALSE
36 GTEx Uterus U91328.19 0.38 0.05 enet 21 0.04 6.2e-02 -8.4 8.8 1.1e-18 -0.24 0.16 0.18 FALSE
37 GTEx Vagina U91328.19 0.45 0.27 lasso 4 0.26 9.4e-07 -7.5 7.4 1.8e-13 -0.33 0.63 0.04 FALSE
38 METSIM Adipose U91328.19 0.19 0.24 lasso 23 0.25 1.7e-36 -7.5 8.2 3.7e-16 -0.31 1.00 0.00 FALSE
39 METSIM Adipose U91328.20 0.07 0.04 bslmm 658 0.04 8.9e-07 -1.4 6.2 5.5e-10 -0.45 0.85 0.12 FALSE
40 YFS Blood TRIM38 0.37 0.31 bslmm 672 0.34 3.8e-115 -7.0 -5.4 6.0e-08 0.18 1.00 0.00 FALSE
41 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma LRRC16A 0.07 0.04 blup 288 0.03 2.8e-04 -4.6 -5.8 4.9e-09 -0.03 0.04 0.90 TRUE