TWAS
hub
About
Usage
Models
Genes
Traits
[Hub]/) :
Traits
:
Leg fat mass (left)
:
←
→
chr5:152,677,967-154,117,397
Best TWAS P=5.13e-08 · Best GWAS P=2.74e-11 conditioned to 4.07e-08
152.6M
152.8M
153M
153.2M
153.4M
153.6M
153.8M
154M
154.2M
0
2
4
6
8
10
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
ROSMAP
Brain Pre-frontal Cortex
FAM114A2
0.05
0.06
lasso
6
0.05
6.3e-07
-5.4
5.5
5.1e-08
0.25
0.94
0.05
TRUE
1
CommonMind
Brain Pre-frontal Cortex
FAM114A2
0.28
0.39
lasso
9
0.41
1.8e-53
-4.8
5.2
2.5e-07
0.27
1.00
0.00
FALSE
3
The Cancer Genome Atlas
Pheochromocytoma and Paraganglioma
FAM114A2
0.07
0.06
blup
56
0.06
1.5e-03
-4.8
-5.1
2.9e-07
-0.31
0.03
0.56
FALSE