[Hub]/) : Traits : Leg fat-free mass (left) :

chr10:4,236,655-5,844,628

Best TWAS P=1.3e-11 · Best GWAS P=3.7e-10 conditioned to 0.546

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Artery Tibial AKR1C2 0.14 0.10 enet 10 0.15 1.2e-11 -6.2 -5.6 2.7e-08 0.94 0.00 1.00 FALSE
2 GTEx Brain Cerebellar Hemisphere AKR1C1 0.46 0.14 lasso 4 0.23 1.4e-06 -3.1 5.4 8.1e-08 -0.85 0.01 0.96 FALSE
3 GTEx Brain Cortex AKR1C2 0.49 0.10 lasso 11 0.26 1.1e-07 -6.3 -5.2 1.5e-07 0.85 0.01 0.98 FALSE
4 GTEx Cells Transformed fibroblasts AKR1C2 0.28 0.23 lasso 6 0.21 1.9e-15 -6.3 -6.3 3.2e-10 1.00 0.00 1.00 FALSE
5 GTEx Esophagus Muscularis AKR1C2 0.30 0.21 lasso 2 0.19 8.5e-12 -6.3 -6.3 2.9e-10 1.00 0.00 1.00 FALSE
6 GTEx Heart Atrial Appendage AKR1C2 0.28 0.37 lasso 3 0.29 1.2e-13 -6.2 -6.2 5.5e-10 0.98 0.00 1.00 FALSE
7 GTEx Ovary AKR1C3 0.35 0.20 lasso 9 0.22 3.9e-06 -6.3 -5.4 6.0e-08 0.91 0.01 0.96 FALSE
8 GTEx Skin Sun Exposed Lower leg AKR1C2 0.17 0.18 lasso 2 0.18 4.0e-15 -6.2 -6.2 4.3e-10 1.00 0.00 1.00 FALSE
9 GTEx Testis AKR1C2 0.44 0.36 lasso 4 0.36 8.5e-17 -6.3 -6.0 1.6e-09 1.00 0.00 1.00 FALSE
10 ROSMAP Brain Pre-frontal Cortex AKR1C2 0.56 0.40 enet 28 0.46 1.0e-65 -6.3 -6.2 4.5e-10 0.93 0.00 1.00 FALSE
11 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma AKR1C1 0.07 0.04 enet 10 0.02 1.0e-03 -6.1 6.8 1.3e-11 -0.88 0.00 0.99 TRUE
12 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma AKR1C2 0.12 0.11 lasso 6 0.09 1.6e-10 -6.3 -6.3 3.6e-10 1.00 0.00 1.00 FALSE
13 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma AKR1C2 0.29 0.21 lasso 1 0.21 4.7e-12 -6.2 -6.2 5.7e-10 0.98 0.00 1.00 FALSE
14 The Cancer Genome Atlas Brain Lower Grade Glioma AKR1C2 0.09 0.05 blup 62 0.05 3.4e-06 -6.1 -5.1 3.0e-07 0.89 0.00 1.00 FALSE
15 The Cancer Genome Atlas Prostate Adenocarcinoma AKR1C2 0.39 0.18 enet 14 0.23 2.5e-23 -6.3 -6.3 3.1e-10 0.85 0.00 1.00 FALSE
16 The Cancer Genome Atlas Thyroid Carcinoma AKR1C2 0.09 0.08 lasso 3 0.08 7.2e-08 -6.1 -6.0 2.3e-09 0.90 0.00 1.00 FALSE