Hub : Genes

AKR1C3

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1520 0.0360 8.7e-07 0.063 0.036 0.064 0.043 0.044 4.2e-08 2.8e-05 3.3e-08 4.8e-06 4.3e-06
2 GTEx Adipose Subcutaneous 0.1540 0.0620 3.8e-03 0.163 NA 0.146 NA 0.151 2.7e-13 NA 5.4e-12 NA 2.3e-12
3 GTEx Adipose Visceral Omentum 0.3800 0.0980 1.6e-04 0.193 NA 0.221 NA 0.187 2.6e-10 NA 1.0e-11 NA 5.2e-10
4 GTEx Brain Cerebellum 0.2620 0.0860 2.2e-03 -0.003 NA -0.006 NA -0.008 4.1e-01 NA 5.4e-01 NA 6.4e-01
5 GTEx Breast Mammary Tissue (Male) 0.1754 0.1220 1.3e-01 -0.009 NA -0.009 NA -0.012 6.0e-01 NA 5.7e-01 NA 8.1e-01
6 GTEx Breast Mammary Tissue (Female) 0.2644 0.1298 3.7e-02 0.318 NA 0.177 NA 0.243 3.5e-10 NA 5.8e-06 NA 7.2e-08
7 GTEx Cells Transformed fibroblasts 0.2440 0.0540 1.1e-06 0.086 NA 0.146 NA 0.089 5.3e-07 NA 4.9e-11 NA 3.2e-07
8 GTEx Nerve Tibial 0.1364 0.0560 8.3e-03 0.005 NA 0.041 NA 0.006 1.3e-01 NA 7.1e-04 NA 1.1e-01
9 GTEx Ovary 0.3450 0.1180 6.5e-03 0.202 NA 0.080 NA 0.221 1.1e-05 NA 5.4e-03 NA 3.9e-06
10 GTEx Skin Not Sun Exposed Suprapubic 0.1910 0.0750 6.7e-03 -0.003 NA -0.004 NA -0.005 5.0e-01 NA 6.9e-01 NA 1.0e+00
11 METSIM Adipose 0.0806 0.0266 4.4e-05 0.101 0.028 0.094 0.093 0.101 7.4e-15 3.8e-05 7.1e-14 8.3e-14 7.8e-15
12 NTR Blood 0.0289 0.0102 1.8e-04 0.007 0.011 0.004 0.011 0.008 1.6e-03 1.5e-04 1.2e-02 1.7e-04 7.0e-04
13 ROSMAP Brain Pre-frontal Cortex 0.1192 0.0348 5.7e-06 0.058 0.046 0.039 0.050 0.043 5.8e-08 1.3e-06 7.7e-06 4.4e-07 3.0e-06
14 YFS Blood 0.1149 0.0210 0.0e+00 0.077 0.086 0.094 0.099 0.102 7.8e-24 8.5e-27 3.8e-29 9.2e-31 1.9e-31
15 TCGA Breast Invasive Carcinoma 0.0536 0.0298 5.0e-06 0.014 0.027 0.029 NA 0.021 5.0e-04 2.2e-06 1.0e-06 NA 3.0e-05
16 TCGA Prostate Adenocarcinoma 0.0494 0.0334 3.2e-03 0.003 0.011 0.007 NA 0.010 1.4e-01 2.4e-02 6.0e-02 NA 2.6e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16
Bipolar Disorder (2018) 0.4 0.6 3.6 0.2 0.1 1.1 0.9 -0.4 0.0 0.3 -0.1 1.9 0.0 0.2 1.0 0.6 0.6 0.6 -1.0
Bipolar Disorder or Schizophrenia 0.4 1.0 5.6 1.1 -0.7 0.7 1.8 -0.4 -0.8 -1.5 0.4 2.4 0.0 -0.4 0.7 1.1 -0.1 0.3 -0.7
Depressed Affect (Nagel 2018) 0.5 1.0 2.6 0.3 -1.0 -1.5 -1.1 -0.5 -0.9 -0.4 1.1 1.5 0.0 -0.8 -1.6 0.0 -1.1 0.4 -1.2
Depression (Nagel 2018) 1.8 2.6 11.3 -0.6 -1.2 -1.3 -1.9 -1.0 -1.2 -0.2 -0.8 -0.3 0.0 -0.9 -3.2 -1.1 -3.4 -2.0 -2.1
Intelligence (Savage-Jansen 2018) 0.2 0.5 1.9 -1.1 0.5 1.4 0.1 -0.4 0.5 -0.1 -1.2 -0.3 0.0 0.8 -0.0 -0.7 0.7 -0.1 -1.2
Neuroticism (Nagel 2018) 0.3 0.8 4.1 -0.3 -0.3 -0.3 -1.2 -0.2 -0.3 0.8 1.2 0.5 0.0 -0.1 -2.0 -1.6 -0.6 -0.2 -1.0
Schizophrenia (2018) 0.4 0.9 4.6 1.2 -1.0 0.2 1.5 -0.1 -1.0 -2.1 0.7 1.5 0.0 -0.6 0.1 0.9 -0.6 -0.1 -0.0
Schizophrenia vs Biploar Disorder 0.4 0.5 1.7 1.3 -0.0 -0.2 0.8 1.0 -0.0 -0.5 1.3 -0.9 0.0 0.3 0.2 0.0 -0.2 1.2 1.0
Worry (Nagel 2018) 0.5 1.0 7.7 -0.6 0.4 0.2 -1.3 -0.2 0.4 1.4 0.5 -0.1 0.0 0.5 -1.4 -2.8 -0.6 -0.6 -0.8
Alzheimer’s Disease (in mother) 0.7 0.8 3.4 -1.8 0.7 1.3 0.1 0.6 0.7 1.6 0.1 -1.5 0.0 1.1 0.1 0.3 0.7 0.4 0.1
Alzheimer’s Disease (in father) 0.5 0.5 2.0 -0.6 -0.8 -0.2 -1.4 0.1 -0.8 -0.8 -0.3 0.3 0.0 -1.0 -0.2 0.2 1.1 -0.2 1.2
Alzheimer’s Disease (including proxy) 0.5 0.8 3.2 -1.8 0.6 0.4 -0.5 1.3 0.7 1.1 -0.6 -1.1 0.0 0.6 -0.9 0.8 1.1 -0.3 -0.0
Crohns Disease (2017) 0.4 0.9 3.9 -0.2 -1.0 -0.9 -2.0 -1.0 -1.0 0.8 0.2 1.4 0.0 -0.6 -0.3 -1.6 0.2 0.4 -0.5
Irritable Bowel Disease (IBD) 0.2 0.4 1.5 -0.2 0.6 0.8 -0.1 0.1 0.6 1.2 1.1 0.9 0.0 0.8 0.2 -0.9 0.0 0.6 -0.2
Ulcerative Colitis (UC) 0.7 1.3 3.5 -0.9 1.7 1.9 1.4 1.3 1.8 1.5 1.1 0.2 0.0 1.5 0.4 0.3 0.6 0.5 -0.3
Major Depression (MDD) 0.7 0.8 2.8 0.8 -1.4 -1.7 1.0 -0.7 -1.4 -0.8 0.7 -0.0 0.0 -1.5 0.4 0.6 0.3 0.0 -0.7
Reaction Time 0.6 1.1 8.2 -0.4 -0.2 -1.2 -0.0 0.4 -0.2 -0.7 -0.9 0.8 0.0 -0.4 2.9 0.5 1.5 1.6 1.0
Verbal and Numeric Reasoning (VNR) 0.2 0.5 2.4 -1.6 0.4 1.3 0.4 -0.0 0.4 -0.1 1.1 -0.3 0.0 0.6 -0.1 0.2 0.6 0.8 0.2
Breast Cancer 0.7 1.7 6.5 -2.0 -0.8 0.6 0.3 0.9 -0.7 1.1 -1.5 0.6 0.0 -0.8 -2.1 -0.4 -2.6 -0.8 -2.1
Ovarian Cancer 0.5 0.7 2.2 1.1 -0.4 0.6 -0.5 -1.3 -0.5 -0.1 0.2 0.6 0.0 -0.4 1.5 0.6 1.4 0.6 1.4
Prostate Cancer 0.6 0.9 3.3 -1.2 1.0 1.4 -0.6 0.5 0.9 0.6 0.9 0.3 0.0 1.1 1.8 0.2 0.3 1.2 1.1
Age at First Birth 1.1 1.6 5.6 -0.5 1.8 1.8 0.1 2.4 1.8 1.7 1.1 0.2 0.0 1.8 0.5 0.4 0.7 1.2 0.6
Bipolar Disorder (2011) 1.3 1.2 3.7 -1.0 0.9 1.6 1.2 0.0 0.9 1.7 0.1 0.3 0.0 0.8 -1.4 0.9 -0.5 -1.7 -1.9
Body Mass Index (BMI) (2010) 0.5 0.7 2.9 -0.6 1.5 1.0 0.4 1.7 1.6 0.4 0.8 -0.0 0.0 1.1 -0.1 0.0 -0.7 0.1 0.4
Coronary Artery Disease (CAD) 0.8 0.9 4.1 0.1 0.4 1.5 -2.0 0.1 0.3 -1.3 1.9 -0.4 0.0 0.1 0.6 0.5 0.7 -1.0 -0.7
Crohns Disease (2012) 0.4 0.6 2.1 -1.0 -0.6 -0.3 -1.5 -0.6 -0.5 0.7 0.1 0.8 0.0 -0.3 -0.9 -1.4 0.2 0.7 -0.8
Mean Putamen Volume 0.7 0.8 5.8 -0.1 0.2 -0.1 -0.9 0.3 0.2 0.4 -0.2 -0.3 0.0 -0.1 -0.4 -0.4 -1.7 -1.5 -2.4
Fasting Glucose 0.5 0.7 2.6 -0.5 0.9 0.7 -0.4 1.3 1.0 -0.9 0.9 -1.6 0.0 0.8 0.4 0.7 -0.4 0.5 -0.5
HbA1C 0.4 0.4 1.9 0.1 -1.2 0.2 -0.1 0.4 -1.2 -0.1 -0.5 0.5 0.0 -1.4 0.5 0.7 0.5 0.3 0.3
HDL Cholesterol 1.0 1.7 8.0 0.2 -1.2 -1.3 0.2 -0.5 -1.2 -0.7 0.7 2.8 0.0 -1.2 1.4 1.3 2.1 1.2 1.7
LDL Cholesterol 0.9 1.4 7.9 1.0 0.1 -0.6 0.3 -0.1 0.1 -0.3 0.7 1.0 0.0 0.0 2.8 1.8 1.7 1.7 1.6
Lupus 1.3 1.9 10.6 -0.1 1.2 1.3 2.0 0.9 1.2 0.8 1.0 -0.1 0.0 0.9 1.0 0.3 3.3 1.1 2.4
Neuroticism (2016) 0.4 0.6 3.0 0.8 0.1 -0.8 -0.7 -0.3 0.2 1.7 0.4 0.3 0.0 0.2 -1.6 -1.0 -0.3 -0.6 -0.2
Primary Biliary Cirrhosis 0.5 0.7 2.6 -1.2 1.0 0.8 0.2 0.5 1.0 0.8 0.3 -0.9 0.0 0.9 -1.6 -0.3 -0.7 0.7 -0.5
Rheumatoid Arthritis 0.8 1.1 6.4 -1.4 1.3 0.0 1.9 -0.1 1.2 2.5 0.4 -0.2 0.0 1.2 -0.2 -0.6 0.2 0.5 -0.4
Schizophrenia (2014) 0.2 0.5 2.4 1.3 -0.8 0.0 1.5 -0.5 -0.9 -1.1 0.7 0.7 0.0 -0.4 0.0 0.6 0.1 0.2 -0.4
Triglycerides 0.9 1.5 4.5 1.1 0.9 0.4 2.1 1.0 0.9 0.7 1.5 -0.2 0.0 1.1 1.9 0.2 -0.7 1.9 1.8
Type 2 Diabetes (T2D) (2012) 0.5 0.6 1.6 0.2 0.3 1.1 0.6 1.1 0.2 -0.1 1.0 0.5 0.0 -0.2 -1.3 -1.1 -0.7 -1.1 -0.2
Ulcerative Colitis 1.1 1.6 4.4 0.3 1.7 2.0 2.1 -0.0 1.7 1.9 1.4 0.1 0.0 1.9 0.1 0.7 -0.6 1.1 0.0
Blood Eosinophil Count 0.1 0.8 2.6 0.1 0.6 0.4 1.0 -1.3 0.5 0.4 -1.0 0.8 0.0 0.8 -0.1 -1.6 1.0 0.4 1.6
Blood Platelet Count 0.2 2.5 11.3 -0.4 -1.9 -2.1 3.4 -0.7 -1.8 -1.1 -1.2 2.3 0.0 -1.4 0.2 -0.9 -1.7 1.2 1.6
Blood Red Count 0.5 4.4 9.3 1.1 -3.0 -3.0 -1.7 -2.9 -3.0 -1.9 -2.1 1.4 0.0 -2.8 -1.1 -2.2 -1.1 -1.6 -1.7
Blood White Count 0.2 1.7 6.3 0.9 -1.1 -2.4 0.7 -1.3 -1.1 -2.5 -0.9 -0.3 0.0 -1.2 0.4 -1.4 -2.1 -0.6 0.4
Heel T-Score 0.9 7.4 27.2 -1.0 5.0 2.1 1.1 4.0 5.1 2.8 2.0 -1.0 0.0 5.2 -1.1 1.6 -0.3 0.1 1.1
BMI 0.1 0.8 5.5 -0.6 0.7 0.2 0.4 -0.6 0.8 -0.3 0.2 0.9 0.0 0.9 -1.8 -0.7 -0.2 -0.3 -2.4
Height 1.0 19.4 222.0 0.1 4.1 1.7 -2.5 4.1 4.1 -1.6 2.3 -14.9 0.0 4.0 -0.9 1.4 0.8 -1.0 0.3
Waist Hip Ratio (WHR) 1.2 5.4 57.9 0.8 -1.9 -2.8 0.1 -1.0 -1.9 -1.5 -1.2 -7.6 0.0 -1.6 -0.8 0.4 -1.1 -1.8 -0.6
Systolic Blood Pressure 0.2 1.2 6.6 -0.3 -1.3 -0.9 0.5 0.6 -1.3 -1.4 -2.6 -0.1 0.0 -1.1 0.0 -0.7 -0.5 -0.8 -1.6
Smoking Status 0.4 1.0 3.3 1.8 0.4 0.5 -0.3 -1.0 0.5 0.1 1.0 1.2 0.0 0.4 0.6 -1.2 1.4 1.0 1.8
Allergy or Eczema 0.1 0.3 0.7 0.3 0.8 -0.7 0.3 -0.0 0.8 0.6 0.2 -0.6 0.0 0.6 -0.7 0.5 -0.4 -0.2 0.7
Cardiovascular Disease 0.2 0.8 4.1 0.3 1.0 0.0 0.1 0.8 1.1 0.5 -2.0 -1.5 0.0 1.0 -0.3 -0.3 0.5 -0.2 -1.2
Hypothyroidism (self reported) 0.9 2.0 5.4 1.5 -1.9 -1.1 1.1 -1.3 -1.9 -0.3 -1.1 -1.7 0.0 -1.9 -2.3 -1.0 -0.2 -1.0 -1.5
Respiratory disease 0.4 0.8 2.5 0.4 -1.1 -1.0 -0.7 -1.6 -1.1 0.3 -0.4 0.7 0.0 -1.1 -0.8 0.3 0.1 -1.3 -1.3
Type 2 Diabetes (T2D) (2018) 0.6 1.1 7.7 0.2 -0.3 -1.2 -0.3 1.2 -0.2 -0.7 -0.6 -2.8 0.0 0.2 1.6 0.1 1.5 0.3 -0.7
Lung FEV1/FVC ratio 0.2 0.9 5.5 2.4 -0.3 -0.8 -0.4 -1.1 -0.2 0.3 -0.3 -0.6 0.0 -0.5 -0.8 -1.3 -1.2 1.1 1.1
Lung FVC 0.3 1.4 6.1 0.0 1.2 1.4 -1.7 2.5 1.1 -1.0 1.6 1.2 0.0 1.0 0.7 -0.0 0.3 -0.2 1.5
Neuroticism 0.2 0.5 1.5 -0.3 -0.0 0.9 -0.5 -0.5 -0.0 1.2 0.5 0.6 0.0 -0.3 -1.2 -1.1 -0.9 -0.2 -0.6
Chronotype (morning person) 0.4 1.0 5.9 -0.8 -1.0 -0.4 -1.7 -0.4 -1.0 0.5 -1.0 0.2 0.0 -1.0 -0.1 0.4 2.4 -0.5 -1.0
Hair Pigment 0.0 0.6 3.1 1.2 -0.1 0.1 1.0 0.0 -0.2 -1.0 -0.4 0.9 0.0 -0.1 0.6 1.1 0.3 1.8 -0.3
Tanning 0.1 0.8 2.1 0.3 0.8 1.1 -1.0 0.9 0.7 -1.2 0.9 1.0 0.0 0.5 1.5 0.6 0.9 1.1 0.6
Hand grip strength (left) 0.3 0.8 4.4 0.8 0.9 0.2 1.1 1.1 0.8 -0.3 1.1 -2.1 0.0 0.6 -0.2 0.2 0.2 -0.9 1.4
Number of treatments/medications taken 0.5 0.9 4.2 1.1 -0.9 -0.5 -2.1 -0.5 -1.0 -0.1 -1.5 -1.6 0.0 -0.9 -0.6 0.1 0.3 -0.0 -0.8
Average weekly spirits intake 1.2 1.5 5.4 1.0 -0.3 -1.4 1.3 0.5 -0.3 -2.2 -0.8 0.7 0.0 -0.5 2.1 2.3 0.7 1.6 0.2
Sensitivity / hurt feelings 0.2 0.3 2.0 0.6 0.6 0.6 -0.6 0.4 0.6 0.3 1.4 -0.9 0.0 0.4 0.2 -0.4 -0.6 0.2 0.3
Frequency of depressed mood in last 2 weeks 0.7 0.9 4.0 -0.7 0.4 -0.7 -1.2 0.2 0.5 1.5 -0.6 -0.9 0.0 0.5 -2.0 -0.8 -1.4 -0.8 -0.8
Hearing difficulty/problems: Yes 2.2 3.3 8.2 -0.2 2.7 -0.2 1.1 2.2 2.9 1.5 2.3 -0.7 0.0 2.6 1.6 2.5 1.0 2.3 1.1
Relative age of first facial hair 0.7 1.5 5.6 -1.3 0.9 1.5 2.2 0.4 0.9 1.4 1.1 2.4 0.0 1.3 -1.2 -0.2 0.2 0.8 0.9
Other serious medical condition/disability diagnosed by doctor 0.3 0.4 2.2 0.8 -0.2 0.4 0.7 -1.5 -0.2 -0.0 1.1 -0.9 0.0 0.2 0.1 0.3 0.8 0.4 -0.3
Ever used hormone-replacement therapy (HRT) 0.7 0.9 3.0 -0.5 -1.4 -1.1 -1.7 -0.3 -1.4 -0.4 0.2 1.6 0.0 -1.4 -0.0 -0.0 0.6 -0.4 -0.5
Ever had hysterectomy (womb removed) 0.6 0.7 5.5 0.1 0.3 -0.3 -1.3 0.0 0.3 -0.6 -0.6 1.4 0.0 -0.1 -1.0 0.3 -2.3 -0.2 -0.7
Systolic blood pressure, automated reading 0.3 1.0 4.3 -2.1 0.7 0.9 0.1 1.6 0.7 -0.7 -1.4 -0.5 0.0 1.0 -0.7 -0.4 0.8 -0.4 -1.4
Eye problems/disorders: Diabetes related eye disease 0.9 1.0 4.1 0.7 0.3 -0.3 0.8 0.3 0.3 0.6 -1.4 -1.6 0.0 0.9 0.8 0.2 0.3 2.0 1.8
Angina 1.2 1.6 8.1 2.2 0.5 -1.2 -0.3 1.3 0.5 -0.8 0.6 -0.8 0.0 0.7 0.8 2.8 0.4 2.3 1.1
Medication for hormone replacement therapy 0.5 0.6 2.8 0.4 -0.2 0.8 -1.7 -0.5 -0.3 0.8 0.5 0.8 0.0 -0.4 -1.2 0.2 -0.6 0.8 0.9
Vitamin and mineral supplements 0.4 0.5 1.9 -1.0 0.1 -1.2 0.5 0.2 0.2 0.6 -1.1 -0.3 0.0 0.4 -1.0 0.1 -0.8 -1.4 0.2
Supplements: Zinc 0.8 0.8 2.2 1.0 -0.7 0.1 1.5 -1.2 -0.8 -1.2 0.2 -1.5 0.0 -1.2 0.4 0.2 0.8 1.2 0.5
Medication: Co-codamol 0.6 0.7 4.0 -0.6 -0.2 0.7 -1.0 -0.8 -0.2 0.8 -1.3 -0.5 0.0 -0.2 -1.3 -0.4 0.2 -0.7 -2.0
Medication: Metformin 0.7 0.9 11.0 0.3 0.3 -0.7 -0.5 0.7 0.3 0.6 -0.9 -3.3 0.0 0.7 -0.1 0.2 -0.4 0.7 -0.5
Diabetes (father) 0.5 0.6 2.3 0.8 -0.3 -0.4 -1.1 0.1 -0.3 -0.1 0.4 1.0 0.0 -0.4 1.0 1.5 -1.4 -0.5 -1.0
Diabetes (mother) 0.6 0.7 3.1 1.8 -0.6 -0.8 1.1 -0.9 -0.6 -1.2 -0.3 -1.1 0.0 -0.5 0.9 -0.4 0.9 -0.7 -0.1
Severe depression (siblings) 0.6 0.6 3.5 -0.2 -0.3 0.6 -0.4 -0.3 -0.4 0.5 0.8 -1.1 0.0 -0.3 -1.8 -1.9 0.4 -0.4 0.1
Pack years adult smoking proportion 0.5 0.8 2.2 1.4 -0.8 -1.5 0.7 -0.5 -0.8 0.4 -1.0 1.3 0.0 -0.6 0.5 1.0 0.1 1.1 0.9
Impedance of leg (right) 0.3 1.4 4.7 0.4 -1.9 -1.3 0.6 -0.8 -1.9 0.8 -1.1 2.0 0.0 -2.2 0.8 -0.4 -0.8 0.3 0.8
Leg fat-free mass (left) 0.7 3.5 29.4 -0.5 2.4 0.8 -0.7 1.4 2.4 -1.2 0.4 -5.4 0.0 2.4 -1.4 0.3 0.8 -0.6 -0.9
Trunk fat percentage 0.2 0.9 3.5 0.1 1.6 1.0 0.1 0.4 1.6 0.8 0.6 -0.1 0.0 1.9 -0.5 0.2 0.2 1.3 -1.0
Hand grip strength (right) 1.0 2.6 20.0 0.5 1.7 0.4 0.1 2.0 1.7 0.7 1.7 -4.5 0.0 1.3 -1.2 -0.4 0.2 -0.8 2.0
Townsend deprivation index at recruitment 1.8 2.6 12.3 -0.9 2.3 0.2 -0.8 1.6 2.4 1.4 0.6 -0.2 0.0 2.4 -1.2 0.9 -3.5 -0.5 -1.8
Current tobacco smoking 0.4 0.7 5.7 -0.5 0.3 -0.4 -0.2 -0.0 0.3 0.9 -0.3 1.3 0.0 0.2 -0.6 -2.4 -0.8 -0.4 0.9
Average weekly fortified wine intake 1.0 1.2 3.1 0.4 1.8 0.1 -1.6 0.5 1.8 1.5 1.7 0.8 0.0 1.8 -0.3 -0.1 -0.4 -0.3 -0.6
Maternal smoking around birth 0.4 0.6 2.2 -0.4 0.1 1.5 0.8 -0.1 0.1 1.2 -0.1 -0.8 0.0 0.3 -1.0 -1.5 -0.7 -0.3 -0.3
Fed-up feelings 0.7 1.3 9.5 -1.2 -0.6 -0.8 -1.9 -0.5 -0.4 0.4 -0.4 0.3 0.0 -0.6 -3.1 -0.6 -0.2 -1.0 -1.6
Frequency of unenthusiasm / disinterest in last 2 weeks 1.9 2.5 10.0 -0.4 -0.8 -1.8 -1.7 -0.3 -0.7 -0.2 -1.6 -1.9 0.0 -0.4 -3.2 -1.1 -2.9 -1.7 -1.9
Relative age voice broke 1.5 2.3 13.1 -0.4 0.2 1.3 3.1 -0.8 0.1 0.9 0.4 3.6 0.0 0.4 -1.5 -0.5 -0.8 1.5 2.1
Taking other prescription medications 1.6 2.4 11.6 -0.1 -1.6 -0.8 -1.7 -0.8 -1.7 0.1 -3.4 -1.5 0.0 -1.6 -2.2 -1.3 -1.2 -1.8 -1.4
Age when periods started (menarche) 0.3 0.8 2.0 -0.1 -1.2 -0.9 0.6 -1.4 -1.1 0.7 0.3 1.2 0.0 -1.2 -1.1 -0.7 -1.4 0.0 -0.0
Bilateral oophorectomy (both ovaries removed) 0.6 0.7 2.1 0.0 -1.4 -1.4 -0.7 -0.7 -1.3 -0.2 -0.2 -0.7 0.0 -1.4 -1.2 -0.3 0.2 0.2 -0.0
Heel bone mineral density (BMD) T-score, automated (left) 0.7 1.6 5.3 -1.2 1.9 0.2 -0.8 1.2 2.0 2.3 0.8 0.1 0.0 2.0 -2.1 0.3 -0.4 -0.0 0.5
Tinnitus: Yes, but not now, but have in the past 0.5 0.5 1.4 0.0 1.1 0.6 -0.2 1.0 1.1 -1.2 0.8 0.9 0.0 0.9 0.6 0.5 -0.2 -0.3 0.0
Qualifications: CSEs or equivalent 0.7 0.9 3.8 1.1 0.7 0.6 0.7 1.5 0.7 -0.9 -0.5 -1.9 0.0 1.0 0.5 0.9 -0.4 -0.4 -1.1
Serious illness, injury or assault to yourself 0.4 0.4 2.3 1.5 -0.1 0.1 0.8 -0.8 -0.1 1.0 0.0 -0.5 0.0 -0.2 0.1 0.0 1.3 -0.2 0.4
High blood pressure 0.6 1.6 5.5 -0.5 1.8 0.7 0.1 2.4 1.9 1.5 -0.1 -1.6 0.0 2.3 0.4 -0.8 1.1 0.5 -0.3
Hayfever, allergic rhinitis or eczema 0.1 0.3 1.2 -0.3 0.6 -0.6 -0.3 0.2 0.6 0.6 -0.0 0.1 0.0 0.3 -0.4 1.1 0.7 -0.2 0.7
Multivitamins +/- minerals 0.8 1.0 2.8 1.1 1.0 1.1 0.1 1.0 1.1 -0.0 1.7 -0.8 0.0 0.7 1.4 0.4 1.5 1.3 0.6
Stomach or abdominal pain in last month 0.2 0.3 1.1 0.3 -0.7 -0.5 -0.3 -0.5 -0.7 0.3 -0.5 -0.2 0.0 -1.0 -0.0 0.8 0.6 -0.5 -0.4
Supplements: Glucosamine 1.4 1.9 8.4 0.6 0.8 1.1 -0.2 1.1 0.9 0.2 2.3 -0.7 0.0 0.3 2.9 2.6 1.4 1.5 0.5
Diverticular disease/diverticulitis (self-reported) 1.1 1.3 4.2 -2.0 1.7 1.4 0.7 1.5 1.7 0.3 1.2 -0.3 0.0 1.7 -1.0 -0.0 -0.2 0.6 0.7
Medication: Atenolol 0.4 0.5 2.6 0.4 -0.2 1.6 0.5 -0.2 -0.3 -0.1 -0.1 0.6 0.0 -0.1 -0.4 -0.1 -1.4 -0.1 -1.4
Medication: Levothyroxine sodium 0.8 1.4 3.6 1.9 -1.7 -0.7 1.9 -0.6 -1.8 -1.1 -1.0 -1.3 0.0 -1.6 -0.1 0.7 -0.3 1.1 -0.1
Sitting height 1.4 9.9 132.2 -0.0 1.9 0.8 -1.8 2.0 1.8 -2.4 0.1 -11.5 0.0 1.7 -0.6 -0.6 0.1 -1.5 -0.3
Chronic bronchitis/emphysema (father) 0.9 1.1 3.4 0.5 1.2 1.4 -0.9 1.8 1.1 -0.6 1.6 -0.4 0.0 1.1 1.7 0.7 -0.5 0.4 0.6
High blood pressure (mother) 0.3 0.4 1.3 -0.9 -0.6 0.2 0.8 0.8 -0.5 0.7 -0.9 0.8 0.0 -0.2 -0.3 -1.2 0.3 0.2 1.0
Body mass index (BMI) 0.2 0.8 3.1 -0.4 1.4 0.5 -0.6 0.4 1.5 -0.2 0.1 0.6 0.0 1.8 -1.0 0.2 0.6 0.3 -1.6
Impedance of leg (left) 0.2 1.2 3.4 0.8 -1.7 -1.1 1.1 -0.6 -1.7 1.1 -1.2 1.2 0.0 -1.9 0.7 -0.7 -1.1 0.2 0.7
Leg predicted mass (left) 0.7 3.6 30.1 -0.5 2.5 0.9 -0.8 1.5 2.5 -1.2 0.4 -5.5 0.0 2.5 -1.4 0.3 0.8 -0.5 -0.8
Trunk fat mass 0.3 1.3 4.4 -0.2 1.9 1.0 -0.3 0.8 1.9 0.2 0.4 -2.0 0.0 2.1 -1.0 0.4 0.4 0.7 -1.1
Waist circumference 0.4 1.6 8.0 -0.6 1.7 0.5 -1.0 0.7 1.8 -0.0 0.2 -2.8 0.0 2.2 -1.6 -0.3 0.2 -0.4 -1.2
Number of incorrect matches in round 0.5 0.9 4.7 1.0 -0.8 -1.0 -0.9 -0.6 -0.9 -0.6 -1.1 -0.7 0.0 -0.8 -0.2 1.2 -2.2 0.2 0.2
Past tobacco smoking 0.7 1.4 5.4 -2.2 0.5 0.2 0.6 1.9 0.6 0.5 -0.9 -1.2 0.0 0.5 -1.1 0.6 -2.3 -1.0 -1.2
Alcohol usually taken with meals 0.3 0.5 2.2 0.3 0.6 0.1 1.5 1.1 0.7 0.4 -0.6 0.0 0.0 0.7 0.5 0.4 1.0 0.5 -0.3
Nervous feelings 0.6 1.2 6.0 -0.5 0.3 -0.5 -1.5 -0.4 0.3 1.6 0.1 0.9 0.0 0.1 -1.7 -2.5 -0.8 -1.8 -0.5
Frequency of tenseness / restlessness in last 2 weeks 0.5 0.8 3.7 -0.2 -0.5 -0.9 -1.9 -0.4 -0.4 0.4 0.6 -0.1 0.0 -0.6 -1.4 -1.2 -1.5 -1.2 -0.3
Hearing difficulty/problems with background noise 0.7 1.2 3.6 -0.5 1.2 -0.3 1.1 1.6 1.2 1.4 1.3 -0.9 0.0 1.2 0.3 1.3 -0.1 1.9 -0.3
Hair/balding pattern: Pattern 2 0.5 0.7 3.7 -0.1 -0.3 1.2 -0.3 -0.8 -0.3 -0.0 0.7 -0.1 0.0 -0.3 -0.5 -0.2 1.9 -0.8 1.8
Had menopause 0.5 0.6 2.3 0.0 -1.0 -1.5 -1.3 -1.3 -1.0 -0.6 -0.9 0.3 0.0 -0.9 0.6 -0.3 0.1 -0.1 0.2
Had other major operations 0.6 0.7 3.1 -1.1 0.2 0.3 -0.1 0.4 0.2 0.1 -0.7 1.5 0.0 0.4 -1.8 -1.0 0.5 1.0 1.4
Forced vital capacity (FVC) 0.4 1.7 10.7 1.9 0.5 -0.6 0.6 1.5 0.5 -2.0 0.9 -3.3 0.0 0.3 1.2 0.7 -0.1 0.8 1.4
Heel bone mineral density (BMD) T-score, automated (right) 0.8 1.8 4.6 -1.4 2.1 0.7 -1.1 1.0 2.1 1.9 0.9 0.3 0.0 2.1 -2.2 0.4 -1.3 -0.1 -0.3
Ever unenthusiastic/disinterested for a whole week 0.9 1.1 5.7 -1.5 -1.1 -2.4 0.5 0.6 -1.1 0.6 -1.5 0.4 0.0 -1.0 -0.6 -0.1 -0.7 -0.9 -1.6
Qualifications: None of the above 0.2 0.4 1.3 0.5 -0.1 -1.1 -0.8 -0.5 -0.1 0.1 -0.7 0.4 0.0 -0.2 -0.5 -0.2 -1.1 0.3 -0.9
Financial difficulties in last 2 years 1.3 1.7 6.7 -1.3 -0.2 0.2 -1.1 0.1 -0.2 -0.4 -1.8 -0.6 0.0 -0.3 -2.4 -2.6 -0.8 -1.7 -2.1
Mouth/teeth dental problems 0.4 0.6 3.3 0.4 0.1 -0.1 1.8 0.1 0.1 -1.0 0.8 0.3 0.0 0.0 0.9 1.3 0.6 0.5 0.7
Heart attack 0.4 0.5 2.4 0.7 -1.1 -0.1 -0.6 0.1 -1.2 -0.6 0.2 -0.1 0.0 -1.2 -0.4 0.3 0.6 1.6 0.1
Allergy 0.1 0.3 1.4 0.4 0.2 0.2 1.2 0.4 0.2 0.0 0.5 0.2 0.0 0.3 0.9 -0.9 -0.6 0.2 -0.0
Pain all over the body in last month 0.4 0.5 1.6 -1.0 0.7 1.3 -1.1 0.3 0.6 1.2 0.3 0.0 0.0 1.0 0.0 0.4 0.3 -0.2 -0.4
Diabetes (self-reported) 0.9 1.4 16.4 -0.1 0.1 -0.6 -0.3 0.8 0.2 0.5 -1.1 -4.0 0.0 0.6 -0.0 -0.6 1.7 -0.0 -0.5
Hayfever/allergic rhinitis (self-reported) 0.4 0.5 2.9 0.1 -0.8 -0.4 -0.4 -1.0 -0.8 0.3 -0.1 -0.2 0.0 -0.4 -0.8 0.2 1.7 0.0 1.1
Medication: Ramipril 0.7 0.9 3.3 -0.5 -0.3 -1.4 -1.8 -0.5 -0.3 0.4 -1.8 -1.4 0.0 -0.2 -0.3 0.6 0.2 -0.8 -1.3
Medication: Simvastatin 0.5 0.7 2.5 0.7 1.5 -0.1 -0.7 0.8 1.6 0.8 0.8 -0.9 0.0 1.5 0.0 -0.0 0.4 0.3 -0.6
Fluid intelligence score 0.4 0.9 3.6 -0.1 0.4 1.1 1.7 -0.2 0.4 0.5 0.6 0.6 0.0 0.3 0.8 0.9 1.4 1.9 1.3
Illnesses of siblings 0.9 1.2 4.6 -0.3 -0.5 -0.6 2.1 -0.9 -0.6 0.2 -1.2 1.2 0.0 -1.0 2.1 1.4 1.5 -0.0 -0.2
Neuroticism score 0.2 0.5 3.0 0.4 0.6 0.4 0.3 -0.0 0.6 1.3 1.7 -0.5 0.0 0.2 -0.4 -0.9 -0.0 0.2 0.7
Weight 0.5 2.3 13.6 -0.3 2.2 0.6 -0.9 1.1 2.2 -0.7 0.3 -3.7 0.0 2.3 -1.6 0.2 0.7 -0.2 -1.4
Impedance of arm (right) 0.2 1.0 3.4 0.5 -0.3 0.4 1.4 0.3 -0.3 1.3 0.0 1.1 0.0 -0.4 1.4 0.3 -1.4 1.8 1.8
Arm fat percentage (right) 0.2 0.6 2.3 0.0 1.2 0.6 -0.1 0.3 1.3 0.2 0.1 1.2 0.0 1.5 -0.2 0.8 -0.1 1.2 -0.8
Trunk fat-free mass 0.6 3.7 38.9 -0.1 1.6 0.3 -0.9 1.5 1.6 -2.2 0.0 -6.2 0.0 1.6 -1.8 0.3 0.6 -0.7 -0.6
Hip circumference 0.4 1.6 5.6 -0.7 2.3 1.5 -0.9 1.0 2.3 0.6 0.7 0.7 0.0 2.4 -0.7 0.1 1.3 0.9 -0.6
Time employed in main current job 0.6 0.7 3.7 -0.9 -0.6 -1.3 1.9 -0.3 -0.5 0.9 -1.1 0.7 0.0 -0.5 -0.2 1.3 -0.5 0.4 -0.2
Alcohol intake versus 10 years previously 0.7 1.0 7.1 -0.4 0.7 1.5 2.7 1.1 0.7 0.6 0.2 -0.1 0.0 0.7 0.3 -0.5 1.4 -0.8 0.3
Father’s age at death 1.9 2.5 9.8 -0.1 -0.6 -0.8 1.0 1.0 -0.6 -0.9 0.8 2.4 0.0 -0.5 2.8 3.1 2.2 2.2 1.5
Worrier / anxious feelings 0.6 1.1 5.2 -0.2 1.2 1.0 -0.8 0.2 1.2 1.9 1.2 0.8 0.0 1.1 -0.7 -2.3 -0.3 -0.6 0.4
Frequency of tiredness / lethargy in last 2 weeks 1.6 2.6 13.4 -0.4 -0.8 0.1 -3.7 -1.5 -0.8 1.2 -0.1 -1.4 0.0 -0.7 -3.2 -2.0 -1.3 -2.0 -1.1
Falls in the last year 1.1 1.5 7.3 1.4 -0.9 -1.8 0.6 -1.2 -0.8 0.3 -0.7 0.7 0.0 -0.9 2.7 1.0 0.2 2.1 0.9
Hair/balding pattern: Pattern 3 0.4 0.7 5.1 0.7 -0.5 -0.9 0.4 0.2 -0.6 -0.9 -1.3 -2.2 0.0 -0.5 0.4 0.6 0.1 -0.2 -0.5
Number of live births 1.0 1.4 3.4 -0.0 -1.6 -1.7 -0.4 -1.4 -1.5 -1.7 -0.9 1.8 0.0 -1.2 -1.2 -0.9 -0.6 -0.8 -0.5
Forced expiratory volume in 1-second (FEV1) 0.5 1.6 7.8 2.1 0.3 -0.5 1.0 1.1 0.4 -2.0 0.5 -2.8 0.0 0.1 0.9 0.8 0.1 1.1 1.8
Pulse rate 0.5 0.9 2.9 0.3 1.5 -0.7 -0.1 1.1 1.7 0.1 0.9 -0.9 0.0 1.7 0.4 -0.1 1.6 -0.1 -0.2
Happiness 0.4 0.4 1.9 0.4 -0.2 -0.8 -1.4 -0.4 -0.2 0.6 0.8 -0.1 0.0 -0.5 0.8 0.8 1.1 -0.5 0.4
Noisy workplace 0.7 0.8 4.0 -0.7 -0.8 -0.7 -1.4 -0.8 -0.8 -0.9 -0.1 -0.4 0.0 -0.5 -0.5 -1.1 -1.2 -2.0 -0.7
Qualifications: A levels/AS levels or equivalent 0.3 0.6 2.0 -0.7 -0.4 -0.5 1.1 0.7 -0.4 -0.1 0.8 1.4 0.0 -0.4 1.3 1.1 0.8 1.0 -0.3
Serious illness, injury or assault of a close relative in last 2 years 1.1 1.3 3.7 0.7 1.8 1.1 1.1 1.4 1.9 0.6 1.3 0.2 0.0 1.7 0.8 1.3 0.9 0.4 0.2
Mouth/teeth dental problems: Dentures 0.7 1.1 1.9 1.4 -1.3 -1.4 -0.4 -1.1 -1.3 -1.3 -0.6 1.3 0.0 -1.3 1.1 -0.7 1.0 0.9 0.2
Asthma 0.7 1.4 4.9 0.5 -0.7 -1.7 -1.6 -1.1 -0.7 0.8 -1.1 1.2 0.0 -0.7 -0.8 1.5 -0.2 -1.5 -2.2
Medication: Ibuprofen (e.g. Nurofen) 1.1 1.5 6.6 2.6 -1.1 -1.5 -0.7 -0.7 -1.0 -1.6 0.4 -0.4 0.0 -1.1 0.6 1.3 -1.6 0.8 -1.3
Medication: Cholesterol lowering 0.6 0.9 3.1 1.5 -0.5 -1.4 -1.1 -0.1 -0.5 -0.2 -0.4 -1.5 0.0 -0.1 0.4 1.0 1.1 0.6 -1.8
Depression (self-reported) 0.7 0.9 3.5 -0.9 -0.4 -0.6 -1.9 0.4 -0.4 1.0 -1.4 -0.6 0.0 -0.1 -1.3 -1.5 -1.2 0.1 -0.5
Medication: Lansoprazole 1.0 1.1 3.6 1.6 -1.2 -0.1 -0.6 0.6 -1.1 -1.9 0.6 1.4 0.0 -1.5 0.9 0.8 -0.2 0.8 0.9
Prospective memory result 0.7 0.8 2.6 -0.4 0.9 -0.2 -0.5 0.5 1.0 1.3 -0.3 -0.5 0.0 1.1 -1.1 -0.7 -0.9 -1.5 -1.6
Lung cancer (father) 0.6 0.7 2.4 1.5 0.6 0.3 0.7 0.7 0.6 -1.1 -0.2 -0.1 0.0 0.6 1.5 0.6 0.7 1.2 0.5
Illnesses of mother 0.4 0.5 2.9 1.7 -0.3 -0.9 -0.2 -0.7 -0.4 -0.2 0.4 -0.7 0.0 -0.4 0.6 1.3 0.7 0.4 0.3
Forced expiratory volume in 1-second (FEV1), Best measure 0.4 1.2 8.7 0.9 1.1 -0.2 0.6 1.6 1.2 -0.8 0.4 -3.0 0.0 0.8 -0.1 0.2 -0.1 0.3 1.3
Pulse wave Arterial Stiffness index 0.5 0.6 2.0 0.1 1.0 -0.6 0.0 0.3 1.0 -0.4 0.7 0.2 0.0 1.4 -0.9 0.7 -1.2 0.0 -1.2
Impedance of arm (left) 0.2 0.9 3.7 0.7 -0.2 0.0 1.6 -0.0 -0.2 1.4 -0.0 0.6 0.0 -0.3 1.2 0.2 -1.0 1.7 1.9
Arm fat mass (right) 0.2 0.9 3.3 -0.4 1.6 0.7 -0.5 0.8 1.7 -0.1 0.1 -0.5 0.0 1.8 -0.8 0.5 0.4 0.6 -1.3
Trunk predicted mass 0.7 3.8 40.6 -0.1 1.6 0.2 -1.0 1.5 1.6 -2.2 -0.1 -6.4 0.0 1.5 -1.8 0.4 0.8 -0.8 -0.6
Standing height 0.7 6.8 93.5 0.6 1.5 0.2 -0.3 1.8 1.5 -1.7 0.1 -9.7 0.0 1.1 -1.3 0.1 0.3 -0.7 0.5
Length of working week for main job 0.4 0.4 2.0 0.9 -0.5 -0.1 0.3 -0.9 -0.6 -0.3 0.2 -0.9 0.0 -0.6 1.4 0.4 0.6 0.3 -0.0
Exposure to tobacco smoke at home 0.8 0.9 3.7 0.9 0.8 -0.1 1.0 0.1 0.9 -0.8 -0.6 -0.2 0.0 0.8 1.9 1.6 0.7 1.0 0.8
Breastfed as a baby 0.6 0.8 4.0 -1.1 0.2 -1.0 -2.0 1.2 0.2 0.5 0.3 1.6 0.0 -0.1 -0.1 0.7 0.8 -0.2 -0.5
Tense / ‘highly strung’ 0.6 1.0 5.6 -0.1 -0.2 0.5 -1.0 -1.2 -0.3 0.4 1.2 -1.1 0.0 -0.6 -1.1 -2.4 -0.5 -1.7 0.0
Seen doctor (GP) for nerves, anxiety, tension or depression 0.8 1.2 6.5 -0.3 0.7 1.3 -1.3 1.2 0.8 0.9 0.1 -0.1 0.0 0.9 -1.2 -2.6 -1.3 -0.6 -1.2
Hair/balding pattern: Pattern 4 0.2 0.6 2.2 -1.0 -0.1 -1.3 -0.1 1.5 -0.0 -0.3 0.7 0.9 0.0 -0.4 0.3 0.4 -0.0 -0.6 -1.3
Birth weight of first child 0.4 0.8 2.7 1.5 -0.8 -0.2 -0.1 -1.4 -0.8 -1.6 0.7 -0.9 0.0 -0.8 1.1 0.0 0.9 0.6 0.7
Peak expiratory flow (PEF) 0.8 2.0 14.5 1.5 1.0 0.6 0.7 0.8 1.0 -0.7 0.3 -3.8 0.0 0.7 1.0 1.1 1.8 0.7 2.0
Pulse wave reflection index 0.9 1.1 5.3 -0.5 -0.5 -0.3 -1.8 -0.7 -0.5 -0.6 0.0 -0.6 0.0 -0.5 -2.1 -0.3 -2.3 -0.1 -1.3
Ever highly irritable/argumentative for 2 days 0.3 0.3 1.8 -0.3 -0.3 -0.7 1.0 -0.1 -0.2 -0.1 -0.2 0.7 0.0 -0.1 -0.6 -1.4 -0.7 -0.7 0.3
Loud music exposure frequency 0.6 0.7 3.5 -0.4 0.7 0.9 0.7 0.2 0.7 0.5 0.4 0.1 0.0 0.7 0.2 -0.9 0.8 1.5 1.9
Qualifications: O levels/GCSEs or equivalent 1.3 2.1 8.7 -1.2 1.4 0.7 0.3 2.3 1.4 1.0 3.0 -1.2 0.0 1.6 1.7 0.3 1.7 1.0 1.2
Mouth/teeth dental problems: Bleeding gums 0.3 0.4 3.9 0.8 0.2 0.1 -2.0 0.3 0.3 0.8 0.2 -0.0 0.0 0.4 -0.3 -0.4 -0.3 -0.1 -0.7
Blood clot in the leg (DVT) 0.8 1.0 6.5 -0.3 -0.9 -0.4 0.1 0.2 -0.9 -2.5 -0.3 -1.5 0.0 -1.2 -0.4 -1.1 0.4 1.3 0.3
Medication: Paracetamol 0.2 0.4 1.1 -0.1 -0.8 -0.3 -1.0 -0.7 -0.9 0.1 -0.2 -0.4 0.0 -0.8 -0.6 -0.8 0.1 -0.6 -1.1
Headache pain in last month 0.5 0.9 4.9 1.4 -0.8 -1.5 1.0 -0.9 -0.8 -0.7 -2.2 0.2 0.0 -1.0 -0.0 0.1 0.5 0.4 0.4
Medication for cholesterol, blood pressure or diabetes 0.6 1.0 5.6 -0.3 -0.6 0.3 1.6 -1.0 -0.7 -0.7 0.2 2.4 0.0 -1.1 -0.2 -0.3 -0.9 -0.0 1.6
Glaucoma (self-reported) 0.6 0.7 3.9 0.7 -0.8 -0.9 -0.5 -0.4 -0.7 -1.8 -0.4 -2.0 0.0 -0.2 -0.4 -0.9 -0.2 0.2 -0.6
Gout (self-reported) 0.7 0.9 3.5 1.4 -1.0 -0.8 0.3 -0.4 -1.1 -1.4 -0.4 -1.9 0.0 -0.8 1.1 -1.3 -0.3 0.1 0.4
Hypothyroidism/myxoedema (self-reported) 0.9 1.7 4.6 1.4 -1.8 -0.2 1.9 -0.9 -1.8 -0.5 -1.7 -1.4 0.0 -1.7 -2.1 -0.5 -0.4 -0.6 -0.7
Medication: Amlodipine 0.5 0.7 2.4 -0.1 0.2 -0.3 -1.3 0.5 0.2 0.2 -0.4 -1.5 0.0 0.6 -1.4 -1.2 -1.3 -1.1 -0.7
Medication: Ventolin 100micrograms inhaler 1.6 2.0 5.9 0.5 -2.3 -1.6 -1.6 -2.4 -2.3 -0.8 -0.9 1.9 0.0 -2.3 -0.1 -0.3 -0.2 0.5 -0.6
Birth weight 0.2 0.4 1.6 0.8 0.1 0.8 -0.0 -0.7 0.1 -0.2 0.4 1.3 0.0 -0.4 0.8 0.4 1.0 1.0 0.6
Chronic bronchitis/emphysema (mother) 1.0 1.1 4.1 1.5 -0.6 -1.1 1.0 -0.9 -0.7 -1.3 -0.9 2.0 0.0 -0.5 -0.2 -0.5 -1.5 -1.1 -1.2
High blood pressure (siblings) 1.2 1.7 5.2 -0.0 1.8 2.1 -0.5 1.0 1.8 1.1 1.0 -0.8 0.0 2.3 -1.3 -1.3 -1.7 0.4 0.6
Forced vital capacity (FVC), Best measure 0.4 1.3 10.3 0.5 1.1 -0.1 0.4 2.1 1.2 -1.1 0.5 -3.2 0.0 0.9 0.1 0.3 0.0 -0.0 0.9
Body fat percentage 0.2 0.6 2.3 -0.2 1.3 0.7 -0.2 0.0 1.3 0.7 0.3 0.7 0.0 1.5 -0.6 0.3 0.2 1.0 -1.2
Leg fat percentage (right) 0.2 0.6 4.5 -0.5 0.7 -0.3 -0.4 -0.2 0.8 0.3 -0.1 2.1 0.0 0.8 -0.2 0.6 0.1 0.8 -1.3
Arm fat-free mass (right) 0.7 3.5 34.6 -0.6 1.7 0.4 -1.0 1.2 1.7 -1.4 -0.1 -5.9 0.0 1.6 -1.7 0.0 1.2 -1.2 -1.5
Exposure to tobacco smoke outside home 0.7 0.9 4.6 -0.3 0.3 -0.7 -2.2 1.0 0.4 1.7 0.3 -0.8 0.0 0.2 1.3 1.0 -0.5 0.9 -0.0
Comparative body size at age 10 0.8 2.3 6.9 1.2 -2.5 -1.9 -1.4 -0.7 -2.4 -0.2 -2.0 -1.7 0.0 -2.6 -0.9 -0.9 0.1 -1.0 1.1
Number of full brothers 1.2 1.5 4.4 0.9 -1.1 -1.0 -1.4 -1.7 -1.2 -0.8 -0.6 2.1 0.0 -0.8 -1.5 -1.7 -1.7 -0.2 -0.9
Worry too long after embarrassment 1.7 2.8 8.6 0.8 2.6 2.4 2.6 0.8 2.5 1.9 2.9 -0.4 0.0 2.2 0.4 0.1 0.0 0.3 0.3
Seen a psychiatrist for nerves, anxiety, tension or depression 0.5 0.7 3.7 -0.1 -0.9 0.1 -1.6 -0.2 -0.8 1.0 -0.5 0.2 0.0 -0.7 -1.9 -0.8 -0.8 0.1 -0.5
Wheeze or whistling in the chest in last year 0.5 0.9 4.3 -1.1 -0.5 -0.8 0.5 -0.7 -0.5 -1.5 -1.6 0.2 0.0 -0.3 0.5 2.1 1.4 -0.2 0.2
Number of children fathered 1.3 1.4 5.7 0.4 -1.3 -0.1 -1.9 -2.4 -1.4 -0.3 -1.7 -0.1 0.0 -1.2 -1.4 -1.0 -0.4 -1.0 -1.2
Reason for reducing amount of alcohol drunk: Health precaution 2.5 2.9 5.8 -2.4 2.3 1.3 -2.4 2.3 2.3 1.9 -0.3 -1.6 0.0 2.4 -1.0 -0.5 -0.7 -1.2 -1.7
Age at first live birth 0.5 0.8 3.4 -1.2 0.9 0.3 1.1 1.8 0.9 0.5 -0.3 -0.8 0.0 0.7 -0.0 0.9 1.5 1.0 0.0
Pulse wave peak to peak time 0.4 0.5 1.6 -0.0 -0.7 0.8 0.1 0.0 -0.7 0.5 -0.6 -0.9 0.0 -1.2 0.8 -0.5 1.1 0.1 1.3
Health satisfaction 0.6 0.7 2.1 1.2 -0.7 -0.5 1.4 -1.2 -0.7 -0.6 -0.5 -1.3 0.0 -0.6 0.1 0.5 1.1 0.7 1.0
Shortness of breath walking on level ground 1.0 1.2 5.5 -0.6 1.2 -0.2 -0.7 -0.4 1.4 0.8 -0.1 2.0 0.0 1.0 -1.2 0.6 -0.4 -1.0 -2.4
Qualifications: College or University degree 0.4 1.2 6.7 0.1 0.2 1.6 0.1 -0.2 0.2 1.1 2.0 -0.3 0.0 -0.0 0.8 0.6 1.4 1.4 2.6
Eye problems/disorders: None of the above 0.6 0.7 2.9 0.2 1.2 0.3 -0.1 0.6 1.2 -0.2 0.3 1.7 0.0 1.0 -0.7 -0.3 -0.1 -1.0 1.4
Mouth/teeth dental problems: Loose teeth 0.3 0.3 1.9 -0.7 0.3 -0.8 -0.3 0.3 0.4 0.9 1.4 0.1 0.0 0.5 -0.1 -0.9 0.0 0.3 0.4
Emphysema/chronic bronchitis 0.7 0.8 2.7 -0.0 -1.0 0.3 -1.2 -1.6 -1.2 -0.8 -0.4 -0.2 0.0 -1.4 -1.3 -1.1 -0.4 -0.7 0.0
Medication for pain relief, constipation, heartburn 0.3 0.6 2.5 -1.2 -0.1 1.0 1.6 0.3 -0.2 -0.3 -0.4 1.2 0.0 -0.0 0.4 -1.0 0.1 -0.7 0.9
Neck or shoulder pain in last month 0.7 0.9 2.5 1.4 -0.5 -1.6 -0.7 -0.7 -0.4 -1.2 -0.9 -0.9 0.0 -1.1 -0.8 0.2 -1.6 -0.5 -1.2
Medication: Blood pressure 0.9 1.6 9.1 -0.7 1.4 0.3 -1.5 1.8 1.5 0.6 -0.3 -3.0 0.0 2.0 -0.2 0.2 0.1 -0.4 -1.5
Angina (self-reported) 1.3 1.7 8.2 2.0 0.6 -1.1 -0.3 1.6 0.6 -0.7 0.8 -0.8 0.0 0.9 0.7 2.9 0.0 2.4 1.0
Migraine (self-reported) 1.9 2.4 6.6 1.4 1.4 -0.9 2.6 1.5 1.6 -0.6 0.5 -0.4 0.0 1.4 1.4 2.4 0.7 2.2 2.5
Medication: Ibuprofen 1.3 1.5 5.3 2.3 -1.3 -1.3 -0.2 -0.3 -1.4 -2.1 -0.1 0.5 0.0 -1.3 1.6 1.1 -1.1 1.3 -0.7
Medication: Allopurinol 1.5 2.0 7.2 0.6 -1.7 -1.3 -0.8 -1.2 -1.8 -1.2 -2.1 -2.7 0.0 -1.5 -0.2 -1.9 0.4 -1.2 -0.2
Medication: Omeprazole 1.4 1.6 6.6 0.1 -1.8 -1.2 -0.2 -2.6 -1.9 0.6 -2.0 0.4 0.0 -2.0 -1.1 -0.1 -0.5 0.3 -0.9
Medication: Seretide 50 evohaler 2.0 2.3 8.6 2.3 -0.8 -2.9 -1.2 -2.2 -0.8 -1.1 -0.3 1.9 0.0 -0.8 0.4 0.4 -2.2 -0.7 -2.1
Mean time to correctly identify matches 0.5 1.0 6.0 -0.7 0.1 -0.9 -0.9 0.5 0.1 -0.0 -0.7 1.1 0.0 -0.0 2.4 0.6 1.5 1.9 0.4
Heart disease (mother) 0.7 0.8 2.2 -1.5 1.3 1.3 -0.2 0.8 1.4 0.9 0.2 -0.5 0.0 1.4 -0.3 -0.5 -1.1 -0.5 -0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.3 0.3 1.4 -0.5 0.2 -0.3 0.0 -0.8 0.1 1.2 0.3 0.8 0.0 0.5 0.4 -1.0 0.1 0.4 -0.8
Whole body fat mass 0.2 1.0 3.6 -0.2 1.7 0.9 -0.5 0.6 1.8 0.1 0.2 -1.4 0.0 1.9 -1.1 0.3 0.4 0.4 -1.3
Leg fat mass (right) 0.2 0.8 2.9 -0.9 1.6 0.3 -0.7 0.4 1.7 0.1 0.1 -0.5 0.0 1.7 -0.9 0.3 0.3 0.1 -1.5
Arm predicted mass (right) 0.6 3.2 32.8 -0.2 1.6 0.0 -1.1 1.0 1.7 -1.3 0.0 -5.7 0.0 1.6 -1.3 0.2 1.7 -1.0 -1.0
Pulse rate, automated reading 0.2 0.6 2.7 1.4 0.7 -1.0 1.2 -0.4 0.7 -0.5 0.1 0.2 0.0 0.7 1.6 0.7 0.3 -0.0 0.3
Alcohol intake frequency. 0.5 1.1 2.6 -1.3 1.1 0.8 1.6 0.4 1.2 1.5 -0.9 0.5 0.0 1.1 -1.6 -0.9 -1.3 -0.1 0.2
Comparative height size at age 10 0.1 0.6 1.6 -0.5 1.0 0.4 -1.1 0.8 1.0 0.1 -0.0 -1.1 0.0 1.0 -1.2 -1.1 0.5 -0.6 0.1
Number of full sisters 0.2 0.3 0.8 0.9 0.7 -0.5 0.2 0.6 0.8 0.4 0.6 -0.1 0.0 0.9 -0.3 0.2 -0.1 -0.2 -0.1
Suffer from ‘nerves’ 0.5 0.7 3.2 0.7 -0.7 -1.1 -0.7 -1.1 -0.7 0.3 -1.1 0.6 0.0 -0.6 -0.2 -1.8 -1.0 -1.2 -0.5
Overall health rating 0.3 0.6 3.6 -0.2 -0.2 -1.1 -0.6 -0.5 -0.1 -0.4 -1.6 -1.9 0.0 -0.1 -0.6 -0.3 -0.2 0.3 0.4
Chest pain or discomfort 0.2 0.3 1.3 -1.0 0.2 -0.4 0.0 0.8 0.3 -0.2 0.2 0.6 0.0 0.5 0.6 1.1 0.4 0.9 0.4
Had major operations 0.5 0.6 1.6 -0.8 0.4 -0.3 -0.9 0.7 0.4 0.4 -0.8 1.2 0.0 0.8 -0.6 0.6 -1.3 0.7 -1.0
Age at last live birth 0.3 0.4 1.4 -1.2 0.3 0.4 0.2 1.2 0.3 0.7 0.2 -0.2 0.0 0.1 -0.7 -0.5 0.9 -0.8 -1.1
Family relationship satisfaction 0.2 0.3 1.1 -0.9 -0.3 -1.0 -0.2 0.3 -0.2 0.7 0.4 0.2 0.0 -0.6 0.1 1.1 0.2 0.2 -0.2
Leg pain on walking 0.6 0.7 4.4 -0.0 -0.8 -2.1 0.6 -0.2 -0.7 -1.0 0.0 0.9 0.0 -0.7 0.6 0.3 0.2 -0.2 -1.7
Qualifications: NVQ or HND or HNC or equivalent 0.7 0.8 2.2 1.3 -1.0 -0.6 -0.4 -0.4 -1.0 -1.5 -1.1 0.0 0.0 -0.9 -1.1 -1.4 -0.7 -0.7 -0.2
Commuting to job workplace: Car/motor vehicle 1.3 1.5 6.2 1.0 -1.8 -2.5 -0.1 -1.9 -1.7 -0.8 -0.5 0.6 0.0 -1.6 -0.3 -0.9 -1.4 0.6 -0.3
Illness, injury, bereavement, stress in last 2 years 1.2 1.4 5.2 0.7 -2.2 -1.4 0.2 -1.2 -2.3 -1.6 -1.1 0.5 0.0 -1.7 0.7 0.6 -0.2 0.4 1.1
Medication: Aspirin 0.4 0.6 2.0 0.1 0.8 -0.6 -0.5 0.3 0.9 0.4 1.0 -1.4 0.0 0.8 -0.2 1.3 1.2 0.5 0.1
Supplements: Vitamin C 0.6 0.7 4.7 -0.2 0.3 1.0 -0.9 0.2 0.3 0.3 0.8 0.2 0.0 0.4 0.9 1.3 1.3 2.2 0.4
Knee pain experienced in last month 0.4 0.7 3.6 1.9 -0.4 -0.8 1.4 -0.9 -0.4 -1.2 0.3 -0.2 0.0 -0.6 1.1 0.3 -0.5 -0.1 0.2
Hypertension (Self-reported) 0.5 1.5 4.8 -0.8 1.7 0.5 0.2 2.2 1.8 1.4 -0.6 -1.9 0.0 2.2 0.5 -0.7 1.1 0.3 -0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.5 0.6 4.5 2.1 0.0 -0.4 1.0 -0.1 -0.0 0.0 0.0 0.9 0.0 -0.2 0.6 1.0 -0.4 0.9 -0.2
Illnesses of father: Heart disease 0.7 0.9 6.0 -0.5 0.5 0.3 -1.9 -0.6 0.5 1.3 2.4 -1.0 0.0 0.4 0.8 -0.8 -0.2 -0.1 -0.4
Illnesses of siblings: Diabetes 1.2 1.5 5.2 1.3 -1.1 -0.8 -2.3 -1.2 -1.1 -1.5 -0.7 -0.2 0.0 -0.5 -1.7 -2.3 -1.3 0.2 -0.0
Smoking status: Previous 1.0 1.5 8.7 1.8 -0.4 -0.4 0.3 -1.6 -0.4 -0.2 0.7 1.4 0.0 -0.3 1.9 0.5 3.0 1.2 1.0
Forced expiratory volume in 1-second (FEV1), predicted 1.3 2.6 35.3 -0.4 0.2 -0.3 0.5 0.9 0.2 -1.3 -1.0 -5.9 0.0 0.0 -0.6 -0.5 -0.0 -1.3 -0.5
Whole body fat-free mass 0.7 4.0 40.2 -0.3 2.0 0.5 -1.0 1.5 2.0 -1.8 0.2 -6.3 0.0 2.0 -1.7 0.3 0.8 -0.8 -0.8
Leg fat-free mass (right) 0.7 3.8 34.8 -0.3 2.4 0.8 -0.7 1.4 2.4 -1.1 0.4 -5.9 0.0 2.5 -1.5 0.1 0.7 -0.7 -0.9
Arm fat percentage (left) 0.2 0.7 2.8 -0.0 1.4 0.7 0.0 0.2 1.5 0.4 0.0 1.1 0.0 1.7 -0.5 0.7 0.1 1.1 -0.8
Average weekly red wine intake 1.0 1.5 3.9 1.4 1.3 0.9 0.4 1.8 1.2 0.4 2.0 0.5 0.0 1.2 1.5 1.2 1.3 1.6 1.1
Handedness (chirality/laterality): Left-handed 1.2 1.5 6.6 1.5 -1.9 -0.4 0.1 -2.6 -2.0 -1.5 -0.8 0.5 0.0 -1.7 -0.6 -0.1 0.4 -0.5 0.2
Mood swings 0.2 0.3 1.8 1.3 0.0 -0.2 0.2 -0.4 0.1 0.4 1.0 0.2 0.0 -0.0 0.1 0.3 -0.3 1.2 0.8
Loneliness, isolation 0.5 0.7 4.2 0.1 -0.3 -1.0 0.1 -0.4 -0.3 -0.2 0.4 0.9 0.0 -0.5 -2.1 0.1 -1.2 -0.7 -1.4
Long-standing illness, disability or infirmity 0.7 1.0 4.8 -1.3 -0.7 0.2 -1.0 -0.4 -0.8 0.3 -0.6 -1.0 0.0 -0.4 -2.2 -0.5 -0.1 -1.5 -1.8
Ever had bowel cancer screening 1.2 1.4 5.5 -1.1 -0.3 1.4 -1.9 0.7 -0.4 -0.4 -0.8 -1.6 0.0 -0.2 -2.3 -1.8 -1.3 -0.5 -1.2
Diabetes diagnosed by doctor 0.8 1.3 14.9 0.0 -0.2 -0.9 -0.8 0.8 -0.1 0.2 -0.6 -3.9 0.0 0.3 0.2 -0.7 1.3 0.2 -0.6
Ever had stillbirth, spontaneous miscarriage or termination 0.3 0.3 1.2 -1.1 -0.1 0.6 -0.7 0.9 -0.1 0.4 -0.4 0.4 0.0 0.0 -0.4 0.2 0.8 -0.7 -0.7
Friendships satisfaction 0.7 0.9 4.8 -0.2 0.7 0.2 0.1 0.9 0.8 1.0 0.6 -1.8 0.0 0.3 0.4 0.3 1.3 1.1 2.2
Qualifications: nursing, teaching 0.7 1.2 4.4 -1.6 0.3 2.1 -0.6 0.6 0.2 1.0 2.0 0.4 0.0 0.6 1.0 0.4 1.3 0.6 1.6
Commuting to job workplace: Walk 1.0 1.1 4.2 -0.3 0.8 1.7 1.6 1.3 0.8 0.7 0.1 0.5 0.0 0.9 1.3 1.1 2.0 -0.3 0.6
Eye problems/disorders: Cataract 0.5 0.5 1.8 -0.3 -0.6 -0.1 1.1 0.8 -0.6 0.3 -1.0 -1.1 0.0 -0.4 0.8 1.0 1.3 0.2 -0.6
Mouth/teeth dental problems: Mouth ulcers 1.2 1.9 9.6 -1.6 0.2 1.1 -1.0 -0.6 0.1 1.4 0.3 -1.1 0.0 0.2 -3.1 -0.6 -2.7 -1.8 -1.2
Medication for cholesterol 0.4 0.6 3.5 0.2 -0.3 -0.6 1.0 0.1 -0.2 -0.8 0.8 0.5 0.0 -0.3 1.9 1.2 0.8 -0.2 0.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 2.3 2.7 7.2 -0.9 2.7 2.5 -1.0 1.8 2.6 1.6 1.3 -1.2 0.0 2.4 -0.9 -0.9 -0.8 -2.1 -0.4
Back pain experienced in last month 1.1 1.6 4.9 2.2 -1.7 -2.1 -0.5 -1.6 -1.7 -1.4 -0.9 -1.2 0.0 -1.7 0.3 0.2 -0.2 0.1 -0.9
Mineral and other dietary supplements 0.4 0.6 2.0 -1.3 0.3 -0.1 0.2 -0.4 0.3 0.6 -1.2 -0.8 0.0 0.7 -1.4 -0.8 -1.0 -0.9 -0.2
Breast cancer (self-reported) 0.7 0.9 3.1 1.3 -0.5 -1.5 -1.5 -0.3 -0.4 -1.4 1.8 -0.2 0.0 -0.7 -0.2 0.9 0.7 0.5 0.5
Asthma (self-reported) 0.7 1.4 5.4 0.1 -0.7 -1.7 -1.6 -0.9 -0.7 0.9 -1.5 1.0 0.0 -0.6 -0.7 1.4 -0.2 -1.7 -2.3
Osteoporosis (self-reported) 1.3 1.6 8.7 2.0 -0.3 0.9 2.1 0.7 -0.3 -0.0 1.6 0.5 0.0 -0.6 0.8 1.7 -0.2 0.5 2.9
Osteoarthritis (self-reported) 0.9 1.2 5.3 -1.8 1.1 -0.6 0.1 0.4 1.2 1.0 -0.2 2.3 0.0 0.9 1.0 0.6 1.1 -1.0 -1.3
Medication: Aspirin 0.7 0.9 4.9 0.8 0.6 -0.6 -0.2 0.6 0.7 0.1 1.2 -1.3 0.0 0.7 0.6 2.2 1.5 0.9 0.0
Medication: Gliclazide 0.3 0.3 1.3 -1.2 0.3 0.6 0.1 0.9 0.3 0.5 0.4 -0.8 0.0 0.4 -0.7 -0.6 -0.1 -0.7 -0.1
Illnesses of father: None of the above (group 1) 0.8 1.0 2.5 1.2 -1.1 -0.7 1.4 -0.7 -1.1 -1.6 -1.4 0.2 0.0 -0.9 -1.2 -0.8 1.1 0.2 0.3
Smoking status: Current 0.3 0.5 4.0 -0.1 0.5 -0.2 -0.2 -0.1 0.5 0.8 0.1 1.1 0.0 0.4 -0.5 -2.0 -0.5 -0.3 0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.8 4.3 0.5 0.8 -1.1 0.0 2.1 0.8 -1.7 0.1 -0.2 0.0 0.7 1.3 0.6 -0.3 0.4 0.4
Whole body water mass 0.7 3.9 39.9 -0.3 1.9 0.5 -1.0 1.4 1.9 -1.9 0.2 -6.3 0.0 1.9 -1.7 0.3 0.8 -0.8 -0.7
Leg predicted mass (right) 0.7 3.8 34.6 -0.3 2.4 0.8 -0.6 1.4 2.4 -1.1 0.4 -5.9 0.0 2.4 -1.5 0.1 0.7 -0.7 -0.9
Arm fat mass (left) 0.2 0.9 3.8 -0.2 1.8 0.6 -0.3 0.7 1.8 -0.1 0.1 -0.8 0.0 1.9 -0.6 0.7 0.7 0.7 -1.0
Number of self-reported non-cancer illnesses 1.0 1.8 5.5 -1.2 0.3 1.1 -1.5 0.9 0.3 1.5 -1.9 -1.7 0.0 0.5 -2.3 -1.8 0.2 -0.7 -2.1
Average weekly champagne plus white wine intake 0.6 0.8 4.2 -0.3 1.1 -0.6 0.2 1.3 1.2 2.1 -0.5 -1.1 0.0 0.7 -0.4 0.8 0.8 -0.3 -0.1
Miserableness 0.8 1.3 3.7 1.2 -1.9 -1.9 -0.1 -0.2 -1.9 -1.1 0.4 0.4 0.0 -1.6 -0.1 0.6 -1.9 0.0 0.6
Guilty feelings 0.4 0.6 1.9 -0.5 0.9 1.0 -0.3 0.4 0.9 1.4 1.3 0.2 0.0 0.6 0.4 -1.0 0.6 0.3 0.9
Wears glasses or contact lenses 1.5 1.8 6.3 2.0 -1.7 -1.1 0.2 -1.4 -1.7 -0.8 1.4 2.5 0.0 -1.3 1.7 1.1 0.2 0.5 -0.3
Ever taken oral contraceptive pill 1.3 1.5 4.1 -1.6 1.9 1.2 0.2 0.9 1.9 1.3 1.4 -0.8 0.0 2.0 0.2 1.4 0.9 0.0 0.3
Hearing aid user 0.6 0.7 2.4 0.1 -1.1 -1.1 -0.5 -0.7 -1.1 -0.8 0.2 -0.4 0.0 -1.2 0.3 -0.6 1.6 -0.5 -0.9
Mother’s age at death 1.0 1.2 4.7 0.1 -1.3 -1.0 0.5 -0.5 -1.3 -2.2 0.7 -0.1 0.0 -1.4 1.2 0.3 1.7 1.1 1.4
Financial situation satisfaction 0.4 0.4 2.0 -0.3 -0.7 0.0 1.4 0.4 -0.7 0.5 -0.0 -0.4 0.0 -0.8 0.8 -0.6 0.1 -0.8 0.9
Tinnitus: Yes, now most or all of the time 1.5 1.8 11.0 -1.2 -1.0 -0.5 -1.1 -1.1 -1.0 0.7 -0.3 -0.9 0.0 -1.3 -3.3 -1.9 -0.3 -1.8 -1.3
Commuting to job workplace: Public transport 0.5 0.6 2.3 0.6 0.5 1.1 0.2 1.0 0.5 -0.9 -1.5 -1.5 0.0 0.6 0.1 0.6 1.0 0.2 0.1
Eye problems/disorders: Glaucoma 1.3 1.6 5.5 1.2 -1.7 -1.2 -0.2 -1.4 -1.7 -2.3 -0.3 -2.1 0.0 -1.4 -0.5 -1.5 -0.3 0.1 -0.1
Medication: Blood pressure 0.3 0.6 2.6 -1.1 0.5 0.8 -0.8 0.6 0.5 0.3 -0.8 -0.5 0.0 0.5 -1.1 -1.6 -0.8 -0.5 -0.9
Pain type(s) experienced in last month: Hip pain 0.4 0.5 1.7 1.0 0.6 -0.5 0.5 -0.2 0.6 -0.8 1.1 1.3 0.0 0.8 0.4 -0.8 -0.9 0.3 0.4
Supplements: Fish oil (including cod liver oil) 0.6 0.8 3.8 1.1 0.4 0.6 -0.5 1.0 0.4 -0.1 1.0 1.0 0.0 0.2 1.9 0.3 1.3 1.3 -0.1
High cholesterol (Self-reported) 0.4 0.6 2.8 1.7 -0.3 -1.3 -0.7 -0.7 -0.2 -0.5 -0.8 -0.2 0.0 -0.0 -0.3 0.2 -0.3 1.6 -1.1
Medication: Bendroflumethiazide 0.5 0.7 4.2 0.2 0.3 -0.1 0.6 1.4 0.3 0.0 -0.5 -1.5 0.0 0.4 2.0 0.2 1.0 0.7 0.7
Medication: Paracetamol 0.3 0.5 1.2 -0.8 -0.9 -0.5 -0.9 -0.5 -1.1 0.4 -1.1 0.2 0.0 -1.1 -0.1 -1.0 0.0 -0.3 -0.8
Medication: Lisinopril 0.6 0.8 3.1 -1.0 -0.4 -0.4 1.5 0.5 -0.4 0.4 -0.6 0.5 0.0 -0.3 1.3 0.9 1.2 1.8 0.9
Medication: Atorvastatin 1.4 1.7 4.5 1.6 -1.7 -1.7 -0.5 -1.3 -1.7 -1.4 -2.1 -1.6 0.0 -1.2 0.2 0.6 0.5 1.1 -1.1
Illnesses of father: High blood pressure 0.3 0.3 2.8 -1.3 0.2 0.6 0.2 0.3 0.2 1.7 -0.1 0.2 0.0 0.1 0.1 0.1 0.0 0.3 0.3
Alcohol drinker status: Never 0.9 1.0 3.3 -0.6 -0.1 -0.3 -1.3 0.0 -0.0 -1.2 -1.3 1.6 0.0 -0.0 -1.2 -0.8 -1.5 -0.9 -1.8
Ever smoked 0.9 1.5 4.3 2.1 -0.9 -0.3 -0.2 -2.0 -1.0 -0.5 -0.0 1.6 0.0 -1.0 0.8 -1.3 1.6 1.4 1.9
Basal metabolic rate 0.6 3.4 32.0 -0.4 2.0 0.5 -0.9 1.3 2.0 -1.5 0.2 -5.7 0.0 2.0 -1.7 0.2 0.8 -0.6 -1.0
Leg fat percentage (left) 0.1 0.5 2.4 -0.4 0.8 -0.1 -0.2 -0.1 0.9 0.7 -0.3 1.5 0.0 1.0 -0.6 0.3 -0.1 0.6 -1.5
Arm fat-free mass (left) 0.6 3.1 33.2 -0.1 1.4 -0.1 -1.0 1.1 1.4 -1.8 -0.1 -5.8 0.0 1.3 -1.1 0.2 1.3 -0.9 -1.1
Number of operations (self-reported) 0.9 1.3 5.6 -0.5 -1.1 -0.8 -1.4 -0.9 -1.1 -0.5 -2.4 0.9 0.0 -0.7 -2.2 -0.4 -0.8 0.0 -1.5
Average weekly beer plus cider intake 0.2 0.3 2.7 -0.4 -0.2 -0.2 -0.3 -1.0 -0.2 0.2 0.1 0.4 0.0 -0.4 0.4 -0.3 -1.7 0.4 -0.0
Irritability 0.4 0.7 3.0 -0.8 0.8 0.5 1.0 0.9 0.8 1.7 1.0 0.2 0.0 0.4 -0.0 -0.1 1.5 -0.1 0.4
Risk taking 0.6 0.9 6.6 0.6 -1.1 0.2 0.9 -0.7 -1.2 -0.5 0.2 0.3 0.0 -0.8 -0.8 -2.6 -1.0 -0.6 -0.4
Ever had prostate specific antigen (PSA) test 1.6 1.9 6.0 0.1 1.4 0.9 -0.5 1.3 1.4 1.4 1.6 0.1 0.0 1.5 1.6 1.9 1.6 2.4 1.3
Fractured/broken bones in last 5 years 0.3 0.4 3.0 0.7 -0.2 0.3 -0.2 0.2 -0.2 -0.1 1.7 0.9 0.0 -0.4 0.7 0.5 0.3 1.1 0.2
Age started oral contraceptive pill 0.3 0.4 2.2 -1.2 -0.1 0.4 0.1 -0.1 -0.1 0.6 0.7 0.4 0.0 0.3 1.5 0.3 0.7 0.2 0.5
Diastolic blood pressure, automated reading 0.1 0.4 2.8 -0.3 -0.2 -0.5 0.1 0.6 -0.2 -0.9 -1.7 1.1 0.0 -0.2 0.5 -0.0 0.6 -0.4 -0.5
Ever depressed for a whole week 0.4 0.4 2.3 -1.0 -0.9 -1.5 -0.4 0.4 -0.8 0.7 -0.1 0.4 0.0 -0.9 -0.5 -0.0 0.0 -0.6 -0.2
Unable to work because of sickness or disability 0.4 0.5 5.1 0.2 -0.1 -0.6 -0.1 -0.9 0.0 -0.3 -0.0 2.3 0.0 0.4 -0.0 0.6 -1.2 -0.3 -0.1
Commuting to job workplace: Cycle 1.0 1.2 2.8 -1.6 1.5 1.3 -0.4 1.1 1.5 1.4 0.2 0.4 0.0 1.7 0.2 0.8 1.2 -1.1 0.2
Myopia 1.0 1.5 8.0 0.2 -1.0 -0.5 -1.8 -0.4 -0.9 -0.7 -0.8 -1.3 0.0 -1.0 -2.8 -1.2 -1.9 -0.5 -1.1
Vascular/heart problems diagnosed by doctor 0.6 1.6 5.9 0.7 -1.9 -0.7 0.4 -2.4 -2.0 -1.4 -0.1 1.5 0.0 -2.3 -0.1 0.3 -1.0 -0.7 0.1
Cholesterol lowering medication 0.4 0.6 1.8 0.8 0.8 0.0 -0.7 -0.2 0.8 -0.3 -0.5 -0.6 0.0 0.8 -1.4 -1.3 -1.2 0.3 0.4
Medication: Omeprazole (e.g. Zanprol) 0.5 0.6 2.5 0.2 -0.9 -0.8 0.2 -1.6 -0.9 0.2 -1.0 0.5 0.0 -1.2 -0.2 0.4 -0.1 1.3 0.2
Pain experienced in last month 0.5 0.9 6.3 -2.5 0.8 0.3 -1.0 1.0 0.8 1.5 0.5 0.0 0.0 1.1 -0.5 -0.1 -0.3 -0.1 0.8
Supplements: Calcium 0.7 0.8 2.1 0.5 -1.2 0.2 -0.2 -0.6 -1.3 -0.6 -0.8 0.4 0.0 -1.4 -1.0 -1.1 -1.2 -0.4 1.2
Basal cell carcinoma (self-reported) 0.9 1.1 3.1 -0.3 1.7 0.8 -0.8 1.0 1.8 0.5 1.4 0.8 0.0 1.6 0.8 1.4 0.3 -0.2 0.8
Heart attack/myocardial infarction (self-reported) 0.3 0.4 1.6 0.6 -0.9 0.1 -0.4 0.2 -1.0 -0.7 0.1 -0.3 0.0 -1.0 -0.6 0.3 0.2 1.3 -0.1
Deep venous thrombosis (DVT) (self-reported) 0.7 0.9 5.3 -0.5 -1.0 -0.4 0.0 0.1 -1.1 -2.3 -0.3 -1.3 0.0 -1.4 -0.3 -1.2 -0.0 1.0 0.4
Heart disease (siblings) 1.1 1.4 3.6 -0.8 0.9 -0.3 -1.8 1.4 0.9 -0.0 1.1 -1.7 0.0 1.1 -1.1 -1.3 -0.9 -1.5 -1.9
Alcohol drinker status: Previous 0.5 0.5 1.9 -1.1 -0.5 -0.7 -0.2 -1.4 -0.6 1.1 -1.1 0.2 0.0 -0.2 -0.1 0.3 0.9 0.9 0.5
Pack years of smoking 0.6 0.9 2.2 1.2 -1.0 -1.5 0.7 -0.8 -1.0 0.3 -0.9 1.3 0.0 -0.7 0.8 1.1 0.1 1.3 0.7
Impedance of whole body 0.2 0.9 2.5 0.9 -1.0 -0.5 1.4 -0.4 -1.0 1.6 -0.5 0.8 0.0 -1.1 1.2 -0.0 -0.7 1.1 1.2
Leg fat mass (left) 0.2 0.9 3.1 -0.9 1.6 0.4 -0.6 0.4 1.7 0.3 -0.1 -0.9 0.0 1.7 -1.2 0.1 0.3 -0.1 -1.6
Arm predicted mass (left) 0.6 2.9 30.4 -0.3 1.4 0.2 -1.1 1.1 1.4 -1.7 -0.0 -5.5 0.0 1.3 -1.3 0.1 1.1 -0.8 -1.1