TWAS hub - AKR1C2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.3070	0.0520	2.1e-12	0.064	0.131	0.138	0.163	0.155	3.2e-08	1.3e-15	1.8e-16	2.1e-19	1.8e-18
2	GTEx	Artery Tibial	0.1427	0.0424	1.5e-04	0.096	NA	0.148	NA	0.142	6.2e-08	NA	1.2e-11	NA	3.1e-11
3	GTEx	Brain Cerebellum	0.2680	0.1010	7.9e-03	0.043	NA	0.109	NA	0.106	2.1e-02	NA	4.1e-04	NA	4.9e-04
4	GTEx	Brain Cortex	0.4870	0.1050	1.8e-04	0.098	NA	0.235	NA	0.255	1.2e-03	NA	3.9e-07	NA	1.1e-07
5	GTEx	Brain Hippocampus	0.3492	0.1175	8.7e-03	0.126	NA	0.119	NA	0.162	7.4e-04	NA	9.9e-04	NA	1.3e-04
6	GTEx	Cells Transformed fibroblasts	0.2850	0.0560	3.4e-08	0.226	NA	0.195	NA	0.207	7.0e-17	NA	1.5e-14	NA	1.9e-15
7	GTEx	Esophagus Muscularis	0.2950	0.0720	2.7e-05	0.211	NA	0.191	NA	0.192	6.2e-13	NA	9.1e-12	NA	8.5e-12
8	GTEx	Heart Atrial Appendage	0.2750	0.0780	2.2e-03	0.368	NA	0.280	NA	0.293	1.7e-17	NA	5.3e-13	NA	1.2e-13
9	GTEx	Muscle Skeletal	0.1071	0.0385	2.2e-03	0.031	NA	0.047	NA	0.047	4.4e-04	NA	2.0e-05	NA	2.1e-05
10	GTEx	Skin Sun Exposed Lower leg	0.1720	0.0420	3.1e-06	0.182	NA	0.177	NA	0.184	5.7e-15	NA	1.4e-14	NA	4.0e-15
11	GTEx	Testis	0.4370	0.0800	1.3e-06	0.359	NA	0.339	NA	0.359	8.2e-17	NA	9.9e-16	NA	8.5e-17
12	METSIM	Adipose	0.0594	0.0250	2.5e-03	0.001	0.017	-0.001	0.014	0.002	2.1e-01	1.3e-03	4.0e-01	3.0e-03	1.7e-01
13	ROSMAP	Brain Pre-frontal Cortex	0.5626	0.0436	0.0e+00	0.402	0.390	0.458	0.457	0.452	1.8e-55	2.6e-53	1.0e-65	1.9e-65	1.6e-64
14	TCGA	Kidney Renal Clear Cell Carcinoma	0.1216	0.0371	4.8e-09	0.111	0.086	0.085	NA	0.092	1.9e-12	6.3e-10	7.7e-10	NA	1.6e-10
15	TCGA	Kidney Renal Papillary Cell Carcinoma	0.2860	0.0770	1.7e-08	0.211	0.193	0.192	NA	0.207	3.1e-12	3.0e-11	3.3e-11	NA	4.7e-12
16	TCGA	Brain Lower Grade Glioma	0.0852	0.0325	9.3e-06	0.050	0.048	0.044	NA	0.046	2.1e-06	3.4e-06	8.3e-06	NA	5.0e-06
17	TCGA	Prostate Adenocarcinoma	0.3901	0.0732	0.0e+00	0.181	0.215	0.226	NA	0.214	1.5e-18	4.3e-22	2.5e-23	NA	4.5e-22
18	TCGA	Soft Tissue Sarcoma	0.0750	0.0420	3.8e-03	0.036	0.052	0.064	NA	0.059	3.1e-03	5.1e-04	1.1e-04	NA	2.0e-04
19	TCGA	Thyroid Carcinoma	0.0940	0.0390	3.0e-05	0.078	0.057	0.073	NA	0.076	5.0e-08	2.8e-06	1.3e-07	NA	7.2e-08

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19
Sitting height	15.1	106.8	146.4	-8.2	-11.3	-7.0	-10.0	-6.3	-12.1	-12.0	-11.9	7.2	-12.0	-11.8	-4.0	-11.5	-12.0	-11.9	-10.7	-10.9	-9.1	-11.3
Relative age voice broke	11.6	17.7	26.5	4.0	4.6	2.5	3.6	3.8	4.5	4.5	4.8	-2.5	4.4	4.5	1.2	4.7	4.6	4.8	4.5	5.2	4.5	4.8
Forced expiratory volume in 1-second (FEV1), predicted	11.5	23.9	31.7	-3.1	-5.6	-4.1	-4.8	-3.8	-5.4	-5.4	-5.4	3.1	-5.4	-5.3	-2.7	-5.3	-5.5	-5.4	-5.2	-5.6	-4.7	-5.4
Waist Hip Ratio (WHR)	10.1	45.5	63.7	-5.6	-7.6	-7.9	-5.9	-6.3	-6.9	-7.1	-7.2	4.0	-7.1	-7.0	-3.4	-8.0	-7.2	-7.2	-7.2	-7.4	-5.8	-7.5
Height	9.8	188.5	269.0	-11.2	-14.7	-8.9	-13.4	-6.8	-16.4	-16.2	-16.1	8.5	-16.2	-16.0	-6.2	-14.9	-16.2	-16.1	-14.3	-14.4	-11.2	-15.3
Standing height	7.4	73.8	104.0	-7.2	-9.4	-5.9	-8.4	-5.4	-10.2	-10.2	-9.9	5.2	-10.1	-10.0	-5.1	-9.6	-10.0	-9.9	-8.9	-8.7	-6.5	-9.2
Trunk predicted mass	6.9	39.5	56.7	-5.1	-6.4	-2.1	-6.2	-2.7	-7.5	-7.5	-7.3	4.6	-7.4	-7.2	-4.8	-7.3	-7.4	-7.3	-5.8	-6.8	-5.1	-6.8
Arm fat-free mass (right)	6.9	35.4	49.0	-4.6	-6.1	-2.0	-5.6	-2.7	-7.0	-7.0	-6.8	4.3	-6.9	-6.7	-4.9	-7.0	-7.0	-6.8	-5.4	-6.6	-5.3	-6.7
Whole body fat-free mass	6.9	39.2	55.1	-4.9	-6.5	-2.3	-6.1	-2.9	-7.4	-7.4	-7.2	4.4	-7.4	-7.1	-4.6	-7.3	-7.4	-7.2	-5.9	-7.0	-5.3	-6.9
Arm fat-free mass (left)	6.8	34.3	47.5	-4.6	-6.0	-2.1	-5.4	-2.7	-6.9	-6.9	-6.7	4.4	-6.8	-6.6	-4.5	-6.8	-6.9	-6.7	-5.5	-6.6	-5.2	-6.5
Trunk fat-free mass	6.7	38.2	54.9	-5.0	-6.3	-2.1	-6.1	-2.7	-7.4	-7.4	-7.2	4.5	-7.3	-7.1	-4.8	-7.2	-7.3	-7.2	-5.8	-6.7	-5.0	-6.7
Whole body water mass	6.7	38.5	54.6	-4.9	-6.4	-2.1	-6.0	-2.9	-7.4	-7.4	-7.2	4.5	-7.3	-7.1	-4.5	-7.2	-7.3	-7.2	-5.8	-6.9	-5.1	-6.8
Arm predicted mass (right)	6.6	33.8	47.1	-4.5	-6.0	-1.9	-5.5	-2.6	-6.8	-6.9	-6.7	4.2	-6.8	-6.6	-4.9	-6.8	-6.8	-6.7	-5.3	-6.5	-5.0	-6.5
Diabetes (self-reported)	6.2	9.5	13.4	-3.6	-3.6	-2.7	-3.4	-2.8	-3.2	-3.3	-3.1	0.8	-3.2	-3.2	-0.8	-3.6	-3.3	-3.1	-3.7	-3.2	-2.7	-3.3
Leg fat-free mass (right)	6.2	33.4	45.7	-4.4	-6.1	-2.5	-5.5	-3.0	-6.7	-6.8	-6.7	4.0	-6.7	-6.5	-3.7	-6.6	-6.7	-6.7	-5.6	-6.7	-5.0	-6.5
Leg predicted mass (right)	6.2	33.3	45.7	-4.4	-6.1	-2.5	-5.6	-3.0	-6.7	-6.8	-6.7	4.0	-6.7	-6.5	-3.8	-6.6	-6.7	-6.7	-5.6	-6.7	-5.0	-6.4
Arm predicted mass (left)	6.1	31.2	44.1	-4.4	-5.7	-1.7	-5.3	-2.4	-6.6	-6.6	-6.4	4.2	-6.6	-6.4	-4.3	-6.5	-6.6	-6.4	-5.1	-6.2	-4.9	-6.3
Basal metabolic rate	5.7	31.6	44.0	-4.4	-5.8	-2.1	-5.4	-2.7	-6.6	-6.6	-6.5	3.9	-6.6	-6.4	-4.2	-6.5	-6.6	-6.5	-5.3	-6.5	-4.9	-6.3
Peak expiratory flow (PEF)	5.6	12.9	18.8	-3.7	-3.9	-2.4	-3.1	-1.6	-4.3	-4.3	-4.2	2.7	-4.2	-4.1	-1.2	-4.2	-4.1	-4.2	-3.1	-3.8	-3.2	-3.7
Diabetes diagnosed by doctor	5.6	9.2	14.3	-3.6	-3.5	-2.0	-3.7	-3.1	-3.1	-3.1	-3.1	1.1	-3.1	-3.0	-1.3	-3.8	-3.1	-3.1	-3.8	-2.8	-2.5	-3.1
Leg predicted mass (left)	5.5	28.9	40.1	-4.2	-5.6	-2.3	-5.3	-2.8	-6.3	-6.3	-6.2	3.6	-6.3	-6.1	-3.7	-6.2	-6.3	-6.2	-5.1	-6.3	-4.5	-5.9
Leg fat-free mass (left)	5.4	28.7	39.8	-4.2	-5.6	-2.2	-5.2	-2.7	-6.3	-6.3	-6.2	3.5	-6.2	-6.0	-3.8	-6.2	-6.3	-6.2	-5.1	-6.3	-4.5	-6.0
Hand grip strength (right)	5.2	14.2	23.0	-2.6	-4.2	-2.3	-3.6	-2.9	-4.8	-4.6	-4.5	3.3	-4.6	-4.7	-2.2	-3.9	-4.4	-4.5	-3.1	-3.6	-2.7	-3.3
Qualifications: CSEs or equivalent	5.1	6.7	13.3	-1.7	-2.4	-2.7	-2.9	-1.8	-2.7	-2.7	-2.7	1.3	-2.7	-2.7	-2.2	-2.6	-2.8	-2.7	-3.1	-3.7	-2.3	-2.8
Medication: Metformin	4.8	6.7	11.6	-3.2	-3.1	-2.3	-3.4	-3.2	-2.6	-2.6	-2.5	1.5	-2.6	-2.6	0.2	-3.2	-2.6	-2.5	-2.6	-1.9	-2.0	-2.5
Medication for cholesterol, blood pressure or diabetes	4.4	7.3	11.3	2.3	2.9	2.8	3.2	2.2	2.5	2.5	2.5	-1.2	2.6	2.6	2.4	3.4	2.7	2.5	3.3	3.4	2.4	3.2
Medication: Blood pressure	4.4	7.7	12.4	-2.1	-2.9	-1.9	-3.1	-1.1	-3.0	-3.0	-3.0	0.8	-3.0	-2.9	-1.9	-3.5	-3.1	-3.0	-3.1	-3.3	-2.4	-3.5
Relative age of first facial hair	3.7	7.5	13.6	2.0	3.2	1.0	2.2	3.7	3.1	3.0	3.0	-1.2	3.0	3.0	1.0	2.9	3.1	3.0	2.8	3.4	2.5	3.0
Hair/balding pattern: Pattern 3	3.7	5.5	11.0	-3.3	-1.7	-1.5	-3.2	1.2	-2.6	-2.5	-2.5	1.2	-2.5	-2.4	-0.8	-2.4	-2.6	-2.5	-2.3	-2.1	-2.8	-2.6
Unable to work because of sickness or disability	3.7	4.8	7.9	2.8	2.3	1.7	2.1	0.4	2.5	2.5	2.5	-1.8	2.5	2.6	0.6	2.0	2.5	2.5	2.8	2.0	1.6	1.9
HDL Cholesterol	3.6	6.0	10.0	2.1	2.8	2.2	2.6	2.1	2.4	2.4	2.5	-1.6	2.5	2.4	0.1	2.7	2.6	2.5	3.2	2.6	2.6	2.9
Type 2 Diabetes (T2D) (2018)	3.5	6.5	11.4	-3.2	-2.9	-2.3	-2.9	-2.6	-2.4	-2.3	-2.4	0.9	-2.3	-2.2	-1.8	-3.3	-2.4	-2.4	-3.4	-2.6	-2.4	-2.9
Had other major operations	3.5	4.2	8.1	-0.0	2.3	1.5	1.7	1.9	2.2	2.2	2.5	-1.6	2.2	2.2	-0.8	1.5	2.3	2.5	1.6	2.9	2.2	2.8
Weight	3.0	14.9	22.7	-3.0	-3.9	-1.8	-3.3	-2.0	-4.4	-4.4	-4.3	2.6	-4.4	-4.2	-3.2	-4.5	-4.5	-4.3	-3.7	-4.8	-3.8	-4.5
Medication: Cholesterol lowering	3.0	4.7	9.0	-2.1	-2.3	-3.0	-2.7	-3.0	-1.5	-1.5	-1.5	1.6	-1.5	-1.6	-1.1	-2.6	-1.7	-1.5	-2.7	-2.8	-2.4	-2.4
Number of full brothers	2.9	3.6	5.6	1.4	2.2	2.4	1.3	1.8	2.3	2.0	2.1	0.3	2.1	2.2	0.9	2.1	2.1	2.1	1.7	1.5	2.2	2.2
Medication: Aspirin	2.9	3.8	7.5	-1.6	-1.8	-1.8	-2.3	-0.1	-1.9	-1.9	-2.1	1.6	-1.9	-1.9	-1.6	-2.0	-2.0	-2.1	-1.6	-2.6	-2.0	-2.7
Osteoarthritis (self-reported)	2.8	3.6	7.5	0.5	2.5	0.9	1.5	1.3	2.3	2.4	2.4	-2.7	2.4	2.3	0.3	1.6	2.2	2.4	2.4	1.2	0.2	1.4
Commuting to job workplace: Public transport	2.7	3.2	6.4	-2.3	-1.5	-2.5	-1.9	-1.0	-2.0	-1.9	-1.7	0.2	-1.9	-1.8	-2.4	-1.8	-1.9	-1.7	-1.8	-1.4	-1.6	-1.5
Medication: Atorvastatin	2.7	3.3	6.4	-2.2	-1.8	-2.5	-2.5	-1.1	-1.4	-1.5	-1.4	2.5	-1.5	-1.5	-1.8	-2.2	-1.6	-1.4	-2.1	-1.4	-1.8	-1.8
Forced vital capacity (FVC)	2.6	10.0	15.4	-2.4	-3.5	-2.8	-3.2	-2.0	-3.9	-3.7	-3.8	2.2	-3.7	-3.6	-1.6	-3.4	-3.6	-3.8	-3.1	-2.8	-1.9	-3.2
Chronic bronchitis/emphysema (mother)	2.6	3.0	4.5	2.0	1.9	1.8	1.7	1.8	1.9	1.9	2.0	-0.7	1.9	1.9	-0.6	1.8	1.8	2.0	2.1	1.3	1.0	1.9
Reason for reducing amount of alcohol drunk: Health precaution	2.6	3.1	7.3	-2.5	-1.5	-0.7	-2.7	-0.5	-2.0	-2.0	-2.0	-0.9	-2.0	-2.0	-0.3	-2.1	-2.0	-2.0	-2.0	-1.0	-0.8	-1.9
Eye problems/disorders: None of the above	2.6	3.0	6.2	2.0	1.8	2.4	1.9	0.1	1.8	1.8	1.6	-0.2	1.8	1.8	0.3	2.3	2.0	1.6	2.5	1.0	1.1	2.3
Number of live births	2.4	3.4	6.1	2.0	2.1	2.2	1.6	1.9	1.9	2.0	1.8	0.2	2.0	2.0	-0.1	2.0	2.0	1.8	2.5	1.9	1.2	1.9
Current tobacco smoking	2.3	3.8	8.4	1.3	2.0	2.2	1.2	1.5	1.9	1.9	2.0	-1.2	1.9	2.0	1.1	1.9	2.1	2.0	1.9	2.4	2.9	2.5
Eye problems/disorders: Glaucoma	2.3	2.7	5.7	-0.7	-1.6	-1.3	-1.1	0.2	-1.9	-1.9	-1.9	2.4	-1.9	-1.9	-1.0	-1.4	-1.8	-1.9	-1.8	-1.9	-1.4	-1.7
Waist circumference	2.1	7.6	11.0	-2.4	-2.8	-1.9	-2.4	-2.5	-2.9	-3.0	-3.0	1.3	-3.0	-2.9	-2.2	-3.3	-3.1	-3.0	-2.7	-3.3	-2.6	-3.3
Forced expiratory volume in 1-second (FEV1)	2.1	7.1	10.9	-2.2	-3.0	-2.7	-2.8	-1.5	-3.3	-3.2	-3.2	2.2	-3.1	-3.0	-1.5	-2.9	-3.0	-3.2	-2.6	-2.1	-1.5	-2.5
Glaucoma (self-reported)	2.1	2.5	4.2	-0.7	-1.6	-2.0	-1.4	-0.1	-1.7	-1.7	-1.7	1.4	-1.7	-1.7	-0.8	-1.6	-1.7	-1.7	-1.8	-1.6	-1.6	-1.8
Medication: Allopurinol	2.1	2.8	6.6	-0.8	-2.2	-1.8	-1.6	-2.6	-1.7	-1.7	-1.6	1.6	-1.6	-1.6	-0.2	-1.8	-1.6	-1.6	-1.8	-1.7	-1.4	-1.6
Back pain experienced in last month	2.1	3.1	6.8	-0.8	-1.6	-2.6	-1.1	-0.6	-1.6	-1.7	-1.7	1.4	-1.7	-1.6	-2.1	-1.7	-1.8	-1.7	-1.6	-2.4	-1.7	-2.5
Medication: Aspirin	2.0	2.7	4.8	-1.6	-1.6	-1.5	-2.0	0.2	-1.6	-1.6	-1.9	1.3	-1.6	-1.6	-1.0	-1.6	-1.6	-1.9	-1.4	-2.0	-1.6	-2.2
Pain type(s) experienced in last month: Hip pain	2.0	2.5	7.1	2.7	1.5	0.9	1.5	1.1	1.6	1.7	1.6	-0.6	1.7	1.7	0.9	2.0	1.6	1.6	1.5	1.7	1.7	1.5
Hand grip strength (left)	1.9	4.9	9.9	-1.3	-2.3	-0.5	-1.6	-0.6	-3.0	-2.8	-2.7	3.1	-2.8	-2.9	-1.3	-2.2	-2.7	-2.7	-1.2	-2.3	-1.7	-1.6
Father’s age at death	1.9	2.5	3.9	0.2	1.6	0.2	1.9	0.7	1.8	1.9	2.0	-1.3	2.0	1.8	-0.1	1.2	1.9	2.0	1.5	1.8	1.8	1.8
Forced vital capacity (FVC), Best measure	1.9	7.1	11.7	-2.0	-2.9	-2.5	-3.2	-1.6	-3.4	-3.2	-3.2	1.2	-3.2	-3.2	-0.6	-2.6	-3.1	-3.2	-2.5	-2.2	-1.7	-2.8
Shortness of breath walking on level ground	1.9	2.3	6.9	0.8	1.9	-0.4	0.9	0.7	2.0	2.0	1.9	-2.6	2.0	2.0	0.3	1.5	1.8	1.9	1.1	0.9	-0.1	0.6
Alcohol drinker status: Never	1.9	2.3	3.5	1.0	1.9	1.7	1.2	1.6	1.7	1.7	1.8	-1.2	1.7	1.8	0.3	1.4	1.7	1.8	1.6	1.0	0.7	1.6
Alzheimer’s Disease (in mother)	1.8	2.1	3.6	-1.0	-1.9	-1.4	-1.2	-1.6	-1.4	-1.3	-1.6	1.1	-1.4	-1.6	0.2	-1.4	-1.4	-1.5	-1.3	-1.8	-1.8	-1.6
Forced expiratory volume in 1-second (FEV1), Best measure	1.8	5.7	9.7	-1.8	-2.7	-2.4	-2.8	-1.4	-3.1	-3.0	-3.0	1.2	-2.9	-2.9	-0.3	-2.3	-2.9	-3.0	-2.2	-1.7	-1.4	-2.4
Exposure to tobacco smoke outside home	1.8	2.4	5.4	-2.3	-1.6	-1.2	-1.8	-1.0	-1.4	-1.4	-1.7	0.6	-1.5	-1.5	0.5	-2.0	-1.6	-1.7	-2.1	-1.4	-1.0	-1.9
Diabetes (mother)	1.7	2.1	5.6	-0.1	-1.6	0.3	-0.4	-0.1	-1.7	-1.7	-2.0	2.4	-1.7	-1.5	-1.1	-1.1	-1.7	-2.0	-1.1	-1.9	-0.9	-1.6
Supplements: Glucosamine	1.7	2.3	4.4	-0.9	-1.4	-0.7	-1.2	0.8	-1.8	-1.8	-1.9	-0.4	-1.8	-1.8	-0.1	-1.6	-1.8	-1.8	-1.5	-1.2	-2.1	-2.0
Medication: Levothyroxine sodium	1.7	2.8	4.3	-1.6	-1.6	-2.0	-1.8	-0.5	-1.7	-1.7	-1.6	1.3	-1.7	-1.7	-2.1	-1.8	-1.8	-1.6	-1.9	-1.7	-1.6	-1.8
Medication: Ibuprofen (e.g. Nurofen)	1.7	2.2	4.7	-1.2	-1.0	-2.2	-1.0	0.6	-1.4	-1.5	-1.4	0.8	-1.5	-1.4	-2.0	-1.7	-1.6	-1.4	-1.5	-1.5	-2.0	-1.7
Ever smoked	1.7	2.9	6.8	1.0	1.6	2.1	2.3	1.3	1.8	1.6	1.5	-0.3	1.6	1.6	-0.9	1.7	1.7	1.5	1.6	2.3	2.6	2.0
Ever used hormone-replacement therapy (HRT)	1.6	2.1	3.1	1.7	1.3	1.5	1.5	1.3	1.5	1.8	1.7	0.6	1.7	1.6	-0.5	1.2	1.6	1.7	1.4	1.6	1.1	1.1
Smoking status: Current	1.6	2.6	5.7	0.9	1.7	1.6	0.8	1.2	1.6	1.6	1.7	-1.0	1.6	1.6	0.8	1.7	1.7	1.7	1.6	2.1	2.4	2.1
Wears glasses or contact lenses	1.6	1.9	3.8	1.0	1.6	0.5	1.7	1.3	1.9	1.8	1.6	-0.6	1.8	1.7	-0.5	1.3	1.7	1.6	1.0	1.0	0.8	0.8
Supplements: Calcium	1.6	1.8	4.8	1.7	0.9	1.4	1.1	0.3	1.3	1.3	1.3	0.0	1.2	1.3	0.4	1.5	1.4	1.3	1.4	2.2	1.6	1.9
Medication: Ventolin 100micrograms inhaler	1.5	1.9	3.7	1.0	1.9	0.5	1.0	1.1	1.8	1.7	1.8	0.0	1.7	1.7	-0.0	1.5	1.7	1.8	1.0	1.6	1.1	1.5
Medication for pain relief, constipation, heartburn	1.5	2.6	4.7	1.9	1.4	2.0	1.8	-0.4	1.2	1.3	1.2	-1.6	1.3	1.2	2.1	1.8	1.4	1.2	2.2	1.6	1.9	1.9
Medication: Bendroflumethiazide	1.5	2.3	4.4	-0.6	-1.7	-1.6	-0.4	-1.2	-1.6	-1.4	-1.6	0.8	-1.5	-1.3	-2.0	-1.7	-1.5	-1.6	-2.1	-1.6	-1.2	-1.9
Age when periods started (menarche)	1.4	3.4	5.9	1.3	2.0	-0.1	1.2	1.4	2.0	2.0	2.1	-0.2	1.9	1.9	2.3	2.0	2.0	2.1	1.8	2.4	2.4	2.2
Blood clot in the leg (DVT)	1.4	1.8	3.9	-1.5	-1.5	-0.6	-0.7	-2.0	-1.6	-1.6	-1.3	0.5	-1.5	-1.5	-1.5	-1.4	-1.4	-1.3	-1.9	-1.0	0.5	-0.8
Hypothyroidism (self reported)	1.3	3.0	8.4	-1.1	-1.7	-1.0	-0.6	-0.7	-1.8	-1.8	-1.8	1.2	-1.8	-1.9	-1.7	-1.8	-1.9	-1.8	-1.8	-2.9	-1.8	-2.1
Impedance of leg (right)	1.3	6.5	10.6	1.6	2.7	-0.1	2.5	0.4	2.9	2.9	3.1	-2.5	2.9	2.8	1.1	3.0	2.9	3.1	2.2	3.3	2.4	3.0
Nervous feelings	1.3	2.3	4.7	1.5	1.5	1.9	1.3	0.6	1.5	1.4	1.2	-1.9	1.4	1.5	2.2	1.7	1.5	1.2	1.2	1.5	2.0	1.5
Hearing difficulty/problems with background noise	1.3	2.1	5.1	-0.9	-1.4	-1.6	-2.3	-0.4	-1.5	-1.4	-1.3	0.5	-1.4	-1.3	-2.2	-1.5	-1.6	-1.3	-1.5	-1.1	-0.8	-1.9
Mouth/teeth dental problems: Dentures	1.3	2.2	4.2	1.5	1.2	1.6	1.8	0.1	1.4	1.5	2.0	-0.5	1.6	1.5	-1.1	1.2	1.7	2.0	0.9	1.6	1.7	2.0
Gout (self-reported)	1.3	1.8	6.0	-0.1	-1.8	-2.5	-1.0	-1.4	-1.3	-1.2	-1.2	1.8	-1.2	-1.2	0.4	-1.1	-1.2	-1.1	-1.7	-1.4	-1.0	-1.2
Neck or shoulder pain in last month	1.3	1.8	4.6	-1.3	-1.2	-0.9	-1.8	-0.1	-1.5	-1.5	-1.4	0.5	-1.5	-1.3	-0.7	-1.6	-1.5	-1.4	-1.3	-2.1	-1.1	-1.6
Birth weight of first child	1.2	2.1	4.0	-1.5	-1.8	1.0	-0.8	-0.1	-1.8	-1.8	-2.0	1.1	-1.8	-1.8	-0.4	-1.8	-1.7	-2.0	-1.2	-1.0	-0.8	-1.1
Medication: Amlodipine	1.2	1.7	3.2	-0.1	-1.3	0.0	-0.8	0.2	-1.7	-1.7	-1.7	1.2	-1.7	-1.6	-0.1	-1.5	-1.7	-1.7	-1.0	-1.8	-0.8	-1.5
Medication: Seretide 50 evohaler	1.2	1.3	3.2	0.5	1.4	-0.4	0.5	0.6	1.8	1.4	1.6	-0.2	1.5	1.5	0.3	1.2	1.3	1.6	0.5	1.5	0.9	1.1
Heart disease (siblings)	1.2	1.5	2.9	-1.6	-0.9	-1.2	-1.3	0.0	-1.5	-1.4	-1.1	-0.2	-1.4	-1.4	0.7	-0.9	-1.4	-1.1	-1.7	-1.4	-1.4	-1.4
Cardiovascular Disease	1.1	3.6	6.8	-0.9	-2.2	-2.6	-1.1	-1.7	-1.5	-1.6	-1.8	1.4	-1.6	-1.5	-2.1	-2.5	-1.8	-1.8	-2.5	-2.4	-2.1	-2.3
Other serious medical condition/disability diagnosed by doctor	1.1	1.4	4.0	0.0	-1.1	-0.9	-0.7	0.1	-1.2	-1.2	-1.1	1.7	-1.3	-1.2	-2.0	-0.8	-1.3	-1.1	-1.1	-1.2	-1.0	-1.6
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.5	3.3	-1.8	-0.7	-1.1	-1.4	0.1	-1.3	-1.4	-1.2	-0.1	-1.3	-1.2	0.0	-1.5	-1.4	-1.2	-1.4	-1.4	-1.2	-1.6
High blood pressure (mother)	1.1	1.5	3.3	1.0	0.8	1.2	1.3	-0.2	1.4	1.4	1.3	0.0	1.4	1.4	-0.9	1.1	1.4	1.3	0.6	1.7	1.7	1.8
Health satisfaction	1.1	1.4	2.8	-1.0	-1.3	-1.7	-1.3	-0.1	-1.4	-1.5	-1.4	0.7	-1.4	-1.3	-1.0	-1.5	-1.4	-1.4	-0.9	-0.1	-0.4	-1.2
Hypertension (Self-reported)	1.1	3.0	5.3	-1.0	-1.9	-1.9	-1.3	-0.9	-1.9	-1.8	-1.9	1.2	-1.8	-1.7	-1.1	-2.3	-1.9	-1.9	-2.1	-2.0	-1.4	-2.1
Illnesses of father: Heart disease	1.1	1.6	6.9	-0.9	-1.2	-2.6	-1.3	-1.8	-0.6	-0.7	-1.1	1.0	-0.8	-0.8	1.4	-0.8	-0.8	-1.1	-1.7	-1.1	-1.0	-1.4
Eye problems/disorders: Cataract	1.1	1.2	2.7	-1.3	-1.3	-1.1	-1.2	-0.5	-1.2	-1.1	-0.9	-0.9	-1.1	-1.2	-0.8	-1.6	-1.2	-0.9	-1.2	-0.7	-1.0	-1.2
Type 2 Diabetes (T2D) (2012)	1.0	1.2	5.3	1.3	0.8	0.6	0.7	1.9	1.0	1.1	0.8	0.8	0.8	0.8	2.3	1.4	1.0	0.8	1.4	0.4	0.2	0.6
Number of treatments/medications taken	1.0	1.8	3.5	-1.1	-1.4	-1.3	-1.0	0.3	-1.3	-1.3	-1.3	1.5	-1.3	-1.3	-1.1	-1.7	-1.4	-1.3	-1.6	-1.5	-1.3	-1.9
Trunk fat mass	1.0	4.5	8.0	-1.8	-2.1	-1.6	-1.4	-1.4	-2.2	-2.3	-2.1	1.1	-2.2	-2.1	-2.1	-2.4	-2.4	-2.1	-2.1	-2.8	-2.4	-2.6
Medication: Ramipril	1.0	1.3	2.8	-0.9	-1.5	-1.0	-1.4	-0.6	-1.0	-1.0	-1.2	0.9	-1.0	-0.9	-0.5	-1.7	-1.1	-1.1	-1.4	-1.3	-1.1	-1.5
Length of working week for main job	1.0	1.1	3.2	-0.2	-1.0	-0.8	-1.4	-1.5	-0.9	-1.1	-1.0	1.2	-1.1	-1.1	0.1	-0.9	-1.1	-1.0	-0.8	-1.8	-0.6	-1.0
Breastfed as a baby	1.0	1.3	2.4	0.5	1.3	0.7	1.5	0.3	1.4	1.4	1.3	-1.1	1.4	1.5	0.5	0.7	1.4	1.3	1.4	0.9	1.1	0.7
Hypothyroidism/myxoedema (self-reported)	1.0	1.9	3.6	-1.1	-1.3	-1.0	-0.9	0.0	-1.4	-1.4	-1.5	1.3	-1.4	-1.4	-1.7	-1.6	-1.5	-1.5	-1.6	-1.9	-1.3	-1.6
Number of operations (self-reported)	1.0	1.5	4.0	-0.7	0.8	0.3	0.6	0.1	1.6	1.6	1.7	-1.4	1.7	1.5	0.3	0.5	1.5	1.7	0.7	2.0	0.8	1.4
Fasting Glucose	0.9	1.0	2.4	-1.6	-0.9	-0.2	-1.5	-0.6	-1.4	-1.3	-1.2	-0.3	-1.0	-1.2	0.1	-0.9	-1.2	-1.2	-0.3	-0.8	-0.6	-1.1
Smoking Status	0.9	2.2	5.8	1.3	1.1	1.8	1.8	0.5	1.4	1.3	1.3	-0.6	1.3	1.3	-0.7	1.6	1.5	1.3	1.5	2.1	2.4	1.9
Ever had hysterectomy (womb removed)	0.9	1.0	2.4	0.5	1.1	0.9	0.4	0.8	1.1	1.1	0.9	-0.7	1.1	1.1	0.8	1.1	1.1	0.9	0.7	1.5	1.6	1.1
Supplements: Zinc	0.9	1.0	5.4	-0.4	-1.3	-1.3	-0.3	-2.3	-0.9	-1.0	-0.7	0.8	-1.0	-1.0	-0.9	-1.1	-1.0	-0.7	-0.5	-0.5	-0.9	-0.9
Multivitamins +/- minerals	0.9	1.2	2.4	-0.8	-0.9	-1.2	-0.7	0.4	-1.4	-1.2	-1.3	0.2	-1.2	-1.1	-0.8	-0.9	-1.2	-1.2	-1.6	-1.0	-0.8	-1.4
Commuting to job workplace: Car/motor vehicle	0.9	1.1	4.4	2.1	0.4	0.8	1.3	-0.8	1.3	1.1	0.9	1.3	1.1	1.1	0.7	0.8	1.1	0.9	0.5	0.4	1.1	0.6
Friendships satisfaction	0.9	1.1	3.9	-0.2	-1.5	-1.4	-1.2	-2.0	-1.1	-1.1	-1.1	0.4	-1.1	-1.2	-0.5	-1.0	-1.0	-1.1	-0.8	0.4	0.9	-0.3
Number of self-reported non-cancer illnesses	0.9	1.5	3.8	-1.7	-0.9	-1.6	-1.3	0.3	-1.0	-0.9	-1.1	-0.5	-0.9	-0.8	-0.6	-1.4	-1.1	-1.1	-2.0	-1.2	-1.5	-1.7
Average weekly champagne plus white wine intake	0.9	1.3	4.2	-0.8	-1.1	-2.1	-0.8	-1.7	-0.9	-1.0	-0.9	-1.1	-1.0	-1.1	-0.7	-0.8	-1.1	-0.9	-0.7	-0.9	-1.6	-1.1
Ever taken oral contraceptive pill	0.9	0.9	1.5	-0.8	-0.7	-1.1	-0.9	0.8	-1.1	-1.0	-1.0	-0.8	-1.0	-1.1	-0.4	-1.2	-1.1	-0.9	-0.5	-1.1	-1.2	-1.2
Bipolar Disorder or Schizophrenia	0.8	1.9	4.3	0.9	2.0	0.8	0.7	2.1	1.6	1.5	1.5	-0.8	1.5	1.6	-0.7	1.4	1.5	1.5	1.9	0.9	0.7	1.0
Hearing difficulty/problems: Yes	0.8	1.3	5.0	-1.5	-1.0	-1.6	-2.2	-0.3	-1.0	-1.0	-1.0	-0.0	-1.0	-1.1	-1.6	-0.9	-1.1	-1.0	-0.9	0.0	-0.0	-1.2
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	2.3	-0.6	-1.3	-0.9	-1.5	-1.4	-0.9	-1.0	-1.1	0.7	-1.0	-0.9	0.5	-1.0	-0.9	-1.1	-1.2	0.5	0.3	-0.7
High blood pressure	0.8	2.2	4.2	-0.8	-1.6	-1.7	-1.1	-0.6	-1.6	-1.6	-1.6	1.0	-1.6	-1.4	-0.9	-2.1	-1.7	-1.6	-1.9	-1.8	-1.1	-1.8
Impedance of arm (right)	0.8	3.6	6.1	0.7	1.4	-1.6	1.6	-0.8	2.0	2.0	2.1	-2.4	2.0	1.8	2.5	2.2	2.0	2.1	0.7	2.4	2.1	2.3
Leg fat percentage (right)	0.8	3.0	5.2	1.4	2.1	1.2	2.2	0.7	2.2	2.1	2.3	-1.2	2.1	2.2	-0.6	1.7	2.0	2.3	1.8	1.0	0.8	1.4
Had major operations	0.8	0.9	3.1	-0.1	0.5	-0.2	0.8	-0.6	1.2	1.3	1.1	-1.8	1.3	1.1	0.8	0.3	1.1	1.1	0.1	1.0	0.9	0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	0.9	3.2	-1.4	-0.8	-0.4	-0.8	-0.1	-1.0	-1.0	-0.8	-1.8	-1.0	-1.0	0.6	-0.8	-1.0	-0.8	-1.0	-1.1	-1.1	-0.7
Deep venous thrombosis (DVT) (self-reported)	0.8	1.1	4.8	-1.0	-1.2	-0.5	-0.3	-2.2	-1.1	-1.1	-0.8	0.3	-1.0	-1.0	-1.3	-1.0	-0.9	-0.8	-1.5	-0.8	0.6	-0.3
Bipolar Disorder (2018)	0.7	1.1	4.3	0.2	1.6	0.2	0.9	1.8	1.1	1.0	1.0	-2.1	0.9	1.0	-0.2	1.1	0.9	1.0	1.0	0.2	-0.6	0.4
Schizophrenia vs Biploar Disorder	0.7	1.0	4.9	0.4	-1.1	-1.1	-1.4	-0.9	-1.1	-1.0	-0.9	2.2	-0.9	-0.9	-0.7	-0.3	-0.9	-1.0	-0.8	-0.4	0.2	-0.7
Alzheimer’s Disease (in father)	0.7	0.8	3.4	0.7	0.6	1.2	0.9	-0.2	0.9	0.9	0.6	0.1	1.0	0.9	0.5	0.9	1.0	0.6	0.5	1.1	1.9	0.6
Ovarian Cancer	0.7	0.9	4.0	1.2	0.7	2.0	0.7	1.4	0.3	0.3	0.1	1.3	0.3	0.4	-1.4	0.7	0.4	0.1	1.1	1.1	0.6	0.7
Mean Putamen Volume	0.7	0.8	3.5	0.1	-1.0	-1.9	-1.3	-1.7	-0.2	-0.1	-0.2	-0.0	-0.2	-0.3	0.3	-0.2	-0.4	-0.2	-1.0	-1.0	-1.4	-1.0
Blood Platelet Count	0.7	7.8	14.1	2.7	2.6	0.5	3.8	1.1	3.0	3.2	3.2	-1.3	3.2	3.4	-1.1	2.6	3.3	3.2	2.6	3.1	3.1	3.3
Medication for hormone replacement therapy	0.7	0.8	2.4	0.1	0.8	0.7	0.6	1.3	1.1	1.0	0.9	0.2	1.0	0.9	-0.2	0.9	1.0	0.9	0.7	1.6	1.1	0.9
Severe depression (siblings)	0.7	0.8	2.0	-0.7	-0.8	-0.6	-0.1	1.1	-0.8	-0.8	-1.0	1.2	-0.8	-0.8	-0.8	-1.0	-0.8	-0.9	-1.2	-1.4	-0.4	-1.2
Pack years adult smoking proportion	0.7	1.0	1.5	1.2	1.2	0.8	0.6	1.2	1.1	1.1	1.1	0.6	1.0	1.1	-0.5	0.8	1.1	1.1	1.1	1.0	1.1	1.2
Impedance of leg (left)	0.7	3.4	5.9	1.3	1.8	-0.8	2.1	-0.0	2.1	2.1	2.2	-1.6	2.1	2.0	0.7	2.3	2.1	2.2	1.5	2.4	1.5	2.0
Medication: Simvastatin	0.7	1.0	3.4	0.0	-1.4	-1.0	-0.9	-1.9	-0.8	-0.7	-0.9	0.8	-0.7	-0.8	0.5	-0.7	-0.8	-0.9	-1.3	-1.4	-1.1	-1.5
Worrier / anxious feelings	0.7	1.3	2.9	1.1	0.6	0.9	1.6	0.0	1.5	1.4	0.8	-0.9	1.4	1.4	0.9	1.2	1.4	0.8	-0.0	1.2	1.7	1.0
Pulse rate	0.7	1.1	2.4	-1.2	-1.1	-1.1	-0.0	-0.2	-1.0	-1.1	-1.1	0.3	-1.1	-1.0	0.5	-1.2	-1.1	-1.1	-1.6	-1.5	-0.7	-1.3
Ever highly irritable/argumentative for 2 days	0.7	0.8	2.3	1.3	0.7	0.7	1.5	-0.8	1.0	1.0	0.9	-0.5	1.0	1.1	-0.2	1.0	1.1	0.9	0.8	0.2	0.8	0.8
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	1.9	-1.1	-1.4	-0.4	-0.6	-0.8	-1.3	-1.3	-1.3	-0.7	-1.2	-1.4	0.6	-1.2	-1.2	-1.3	-1.3	-0.5	0.2	-1.3
Comparative body size at age 10	0.7	1.9	8.4	0.1	-2.1	0.6	-0.2	-1.4	-1.6	-1.5	-1.6	2.9	-1.6	-1.5	-0.5	-1.5	-1.4	-1.6	-0.8	-0.8	-0.2	-0.6
Worry too long after embarrassment	0.7	1.1	3.2	0.2	-0.7	-0.4	-0.7	1.8	-1.2	-1.4	-1.4	0.5	-1.4	-1.3	0.5	-0.3	-1.3	-1.4	-0.7	-1.3	-0.4	-1.1
Age at first live birth	0.7	1.2	5.4	-2.3	-0.6	-1.2	-0.7	-0.2	-1.0	-0.9	-0.9	-2.0	-0.9	-1.0	0.9	-1.0	-0.9	-0.9	-0.7	-0.9	-0.8	-0.9
Whole body fat mass	0.7	2.8	6.2	-1.4	-1.5	-1.0	-1.1	-1.0	-1.7	-1.8	-1.6	1.1	-1.7	-1.6	-1.9	-1.9	-1.8	-1.6	-1.5	-2.5	-2.2	-2.1
Ever had bowel cancer screening	0.7	0.8	2.0	-1.2	-1.2	-0.2	-0.6	-0.5	-1.0	-0.9	-1.0	-0.4	-0.9	-1.0	1.0	-1.1	-0.9	-0.9	-1.4	-0.8	-0.5	-1.0
Osteoporosis (self-reported)	0.7	0.9	2.2	1.5	0.7	0.7	0.1	1.2	0.4	0.4	0.5	-0.3	0.4	0.4	-1.3	1.1	0.6	0.5	1.2	1.5	1.4	1.5
Pack years of smoking	0.7	1.1	1.6	0.9	1.2	0.7	0.8	1.0	1.3	1.2	1.2	0.3	1.2	1.2	-0.5	0.7	1.2	1.2	1.0	1.0	1.0	1.2
Schizophrenia (2018)	0.6	1.2	2.4	0.9	1.3	0.9	0.2	1.2	1.1	1.1	1.2	0.4	1.2	1.2	-0.7	0.9	1.2	1.2	1.5	1.0	1.4	1.0
Alzheimer’s Disease (including proxy)	0.6	0.8	2.1	-0.8	-1.2	-0.8	-0.5	-1.2	-0.7	-0.6	-0.8	0.7	-0.7	-0.9	0.7	-0.9	-0.7	-0.8	-0.8	-1.4	-0.9	-1.4
Crohns Disease (2017)	0.6	1.3	2.8	0.8	1.1	1.7	0.8	1.5	1.3	1.1	1.0	-1.3	1.1	1.1	0.8	0.6	1.2	1.0	0.8	1.3	1.4	1.0
Sensitivity / hurt feelings	0.6	0.9	2.0	-0.3	-1.0	-0.1	-1.4	-0.4	-1.1	-1.2	-1.2	-0.1	-1.2	-1.2	-0.3	-1.0	-1.1	-1.2	-1.3	-1.2	-0.0	-1.0
Average weekly fortified wine intake	0.6	0.8	2.0	0.7	0.9	-0.8	0.7	0.2	1.1	1.0	1.0	-0.3	1.0	1.0	1.4	1.2	0.9	1.0	0.2	0.4	0.8	0.4
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	1.8	0.8	0.8	1.3	0.7	1.2	0.5	0.5	0.6	0.2	0.6	0.6	0.9	0.8	0.6	0.6	1.4	0.7	0.3	0.7
Past tobacco smoking	0.6	1.0	2.9	-0.8	-0.7	-1.4	-1.6	-0.3	-1.0	-0.8	-0.7	-0.2	-0.9	-0.8	1.7	-0.9	-0.9	-0.7	-1.0	-1.3	-1.3	-1.0
Illnesses of mother	0.6	0.7	2.0	-0.8	-0.4	-0.7	-1.2	-0.7	-1.0	-1.0	-0.7	0.1	-1.0	-1.0	1.4	-0.8	-1.0	-0.7	-0.1	-0.6	-0.9	-0.7
Impedance of arm (left)	0.6	2.8	4.8	0.8	0.9	-1.9	1.5	-1.1	1.7	1.7	1.7	-2.1	1.7	1.5	2.1	1.8	1.7	1.7	0.5	2.2	1.9	1.9
Loud music exposure frequency	0.6	0.6	2.1	0.5	1.1	1.4	0.2	1.4	0.3	0.4	0.6	0.5	0.4	0.5	-0.9	0.8	0.5	0.6	0.7	0.6	1.0	1.1
Pulse wave peak to peak time	0.6	0.7	2.7	0.2	-1.3	-0.1	-0.6	-1.6	-0.7	-0.6	-0.9	1.1	-0.7	-0.8	0.8	-0.6	-0.6	-0.9	-1.0	0.6	-0.2	-0.3
Mouth/teeth dental problems: Loose teeth	0.6	0.7	2.2	1.5	0.5	0.7	0.5	0.2	0.7	0.8	0.8	0.2	0.8	0.7	0.8	1.3	0.8	0.8	0.2	1.0	1.1	0.6
Suffer from ‘nerves’	0.6	0.9	2.1	0.6	0.5	1.2	1.4	-0.2	1.0	1.0	1.0	0.1	1.0	1.0	1.2	0.7	1.0	1.0	0.6	0.8	0.8	1.4
Smoking status: Previous	0.6	0.8	4.9	0.7	0.3	1.0	1.5	-0.1	0.9	0.8	0.7	0.2	0.9	0.8	-2.2	0.5	0.8	0.7	0.6	1.0	0.7	0.6
Loneliness, isolation	0.6	0.8	1.8	0.4	0.9	-0.7	1.2	0.7	1.1	1.1	1.2	-0.6	1.1	1.2	1.4	0.7	1.0	1.2	0.7	0.3	0.5	0.5
Risk taking	0.6	0.8	2.8	1.3	1.0	0.5	0.9	1.7	0.7	0.7	0.8	0.0	0.7	0.8	1.0	1.2	0.7	0.8	0.7	1.0	0.7	1.0
Fractured/broken bones in last 5 years	0.6	0.8	2.7	-0.1	1.1	-0.0	-1.2	0.2	0.9	0.8	0.9	-0.7	0.9	0.8	-0.6	0.7	0.9	0.9	0.4	1.4	1.7	1.1
Commuting to job workplace: Cycle	0.6	0.8	6.1	-1.9	0.4	0.3	0.2	1.5	-0.1	-0.0	0.1	-2.5	-0.1	-0.1	1.1	-0.1	-0.1	0.1	0.6	-0.0	-0.7	0.2
Vascular/heart problems diagnosed by doctor	0.6	1.7	3.2	0.7	1.4	1.7	1.2	0.6	1.4	1.3	1.4	-0.9	1.4	1.2	0.5	1.8	1.4	1.4	1.7	1.5	0.7	1.6
Impedance of whole body	0.6	2.9	5.2	0.9	1.3	-1.8	1.6	-0.5	1.9	1.9	1.9	-2.1	1.8	1.7	1.5	2.0	1.8	1.9	0.8	2.3	1.7	1.8
Depressed Affect (Nagel 2018)	0.5	1.0	3.9	-0.0	1.3	0.2	0.9	2.0	1.2	1.1	1.1	-0.8	1.1	1.2	0.0	0.5	1.1	1.1	0.4	0.7	1.3	0.3
Coronary Artery Disease (CAD)	0.5	0.6	2.2	0.1	-0.7	-0.1	-0.3	-0.1	-0.7	-0.7	-1.0	0.3	-1.1	-0.8	0.1	-0.5	-0.7	-1.1	-0.7	-1.4	-0.7	-1.5
Crohns Disease (2012)	0.5	0.9	3.7	0.0	0.9	1.3	0.5	1.9	0.7	0.6	1.0	-1.2	0.6	0.6	0.7	0.7	0.7	1.0	1.0	0.8	1.4	0.3
Primary Biliary Cirrhosis	0.5	0.7	2.3	-1.5	-0.3	-0.1	-0.7	1.0	-0.9	-0.9	-0.8	-0.5	-1.0	-0.9	-0.6	-0.7	-1.0	-0.9	-0.7	-0.6	-0.6	-1.1
Stomach or abdominal pain in last month	0.5	0.6	2.3	-0.9	-0.1	-0.3	-1.0	1.3	-0.6	-0.6	-0.4	-0.1	-0.6	-0.5	-1.5	-0.4	-0.6	-0.4	-0.8	-1.0	-0.5	-0.9
Medication: Atenolol	0.5	0.6	2.3	1.2	1.0	-0.2	0.3	0.3	0.9	0.9	1.1	-0.1	0.9	1.0	0.4	1.5	0.8	1.0	0.6	-0.5	-0.4	0.1
Chronic bronchitis/emphysema (father)	0.5	0.6	1.9	0.2	-0.7	-0.3	-0.8	-0.2	-1.0	-0.9	-0.9	1.0	-1.0	-1.0	0.0	-0.8	-0.9	-0.9	-0.1	-1.4	-0.6	-0.5
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.7	3.3	0.7	1.0	1.6	0.3	1.8	0.5	0.4	0.5	-0.1	0.4	0.6	1.1	0.7	0.5	0.5	0.5	1.0	0.9	0.6
Hair/balding pattern: Pattern 2	0.5	0.7	2.0	0.9	0.6	0.3	1.2	-0.2	0.6	0.5	0.7	-0.9	0.5	0.4	-0.1	1.1	0.7	0.7	1.0	0.9	1.4	1.2
Time employed in main current job	0.5	0.5	3.1	0.5	0.1	-0.4	0.7	-1.8	1.0	1.1	0.6	-0.6	1.0	0.9	-0.2	0.1	0.9	0.6	0.4	0.2	0.2	0.2
Tense / ‘highly strung’	0.5	0.8	4.2	-0.5	-0.3	1.6	0.3	1.0	-0.6	-0.8	-0.9	0.8	-0.8	-0.6	2.0	-0.3	-0.7	-0.9	-0.6	-1.0	0.1	-0.5
Mean time to correctly identify matches	0.5	1.0	1.9	-0.4	0.9	0.3	1.0	-0.3	1.2	1.2	1.4	-0.6	1.2	1.2	1.1	0.7	1.2	1.4	0.6	1.0	0.6	1.1
Knee pain experienced in last month	0.5	0.7	3.1	1.2	-0.6	-1.8	-0.7	-0.3	-0.3	-0.4	-0.4	1.5	-0.5	-0.2	-0.5	-0.3	-0.5	-0.4	-0.8	-1.4	-1.1	-0.9
Handedness (chirality/laterality): Left-handed	0.5	0.6	6.6	0.5	0.6	0.9	0.4	2.6	0.4	0.2	0.3	1.3	0.2	0.2	-0.8	0.7	0.2	0.3	0.3	0.0	-0.2	0.5
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	3.2	-1.1	-1.0	-0.7	-1.1	-1.8	-0.4	-0.5	-1.0	-0.3	-0.6	-0.6	0.7	-0.7	-0.6	-1.0	-1.3	-0.6	-0.5	-1.3
Hearing aid user	0.5	0.6	2.4	-1.5	-0.0	0.2	-1.2	1.3	-0.6	-0.7	-0.5	1.1	-0.6	-0.6	-0.1	-0.5	-0.7	-0.5	-0.4	-0.5	-0.9	-0.7
High cholesterol (Self-reported)	0.5	0.9	4.5	-0.8	-0.8	-2.1	-0.8	-1.0	-0.4	-0.5	-0.7	1.5	-0.4	-0.5	-0.1	-0.9	-0.6	-0.7	-1.1	-1.1	-1.1	-1.3
Prostate Cancer	0.4	0.5	4.2	0.3	0.6	0.3	0.1	-0.1	0.5	0.4	0.1	-1.6	0.4	0.4	2.0	0.3	0.4	0.1	0.1	0.6	1.1	0.2
Angina	0.4	0.5	2.2	0.2	-0.8	-1.3	-1.5	-0.7	-0.6	-0.5	-0.4	1.2	-0.5	-0.6	0.1	-0.4	-0.5	-0.4	-0.3	0.1	-0.4	-0.7
Townsend deprivation index at recruitment	0.4	0.6	3.6	-0.1	0.1	-1.1	-1.1	0.1	-0.6	-0.5	-0.1	-1.9	-0.6	-0.5	1.4	-0.3	-0.6	-0.1	-0.1	-0.7	-0.8	-0.5
Serious illness, injury or assault to yourself	0.4	0.5	1.5	0.3	-0.5	-0.9	-0.2	-0.4	-0.7	-0.6	-0.6	1.2	-0.6	-0.5	-1.2	-0.2	-0.6	-0.6	-0.6	-0.5	-0.9	-0.7
Qualifications: A levels/AS levels or equivalent	0.4	1.0	5.6	-0.3	0.7	-0.9	1.1	-0.4	1.0	1.2	1.0	-2.4	1.2	1.1	1.1	0.4	1.1	1.0	0.3	0.6	0.3	0.4
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	1.1	0.7	-0.5	-0.2	0.2	-0.0	-0.9	-0.8	-0.7	1.0	-0.8	-0.8	-0.5	-0.3	-0.8	-0.7	-0.5	-1.1	-0.6	-0.9
Birth weight	0.4	0.9	5.6	-0.2	0.8	2.4	1.0	1.2	0.7	0.4	0.5	-0.8	0.5	0.6	-0.4	0.5	0.6	0.5	0.8	1.3	1.6	1.3
Angina (self-reported)	0.4	0.5	2.4	0.2	-0.8	-1.3	-1.6	-0.5	-0.6	-0.5	-0.4	1.1	-0.5	-0.6	0.2	-0.4	-0.5	-0.4	-0.3	0.2	-0.2	-0.7
Migraine (self-reported)	0.4	0.5	1.9	-0.7	-0.7	-1.4	-0.4	-0.6	-1.0	-0.8	-0.7	0.7	-0.8	-0.8	-0.3	-0.6	-0.7	-0.7	-0.2	0.0	0.5	-0.1
Medication: Ibuprofen	0.4	0.5	2.2	-0.7	-0.2	-1.3	0.2	0.6	-0.5	-0.5	-0.5	0.2	-0.5	-0.4	-1.5	-1.0	-0.6	-0.5	-0.7	-0.5	-1.1	-0.6
Medication: Omeprazole	0.4	0.5	1.6	-1.3	0.4	-0.3	0.1	-0.2	1.1	0.9	1.0	-0.8	0.8	0.7	0.1	0.1	0.8	1.0	-0.0	0.6	0.2	0.5
Alcohol intake frequency.	0.4	0.9	2.3	1.5	0.7	1.0	1.3	0.6	0.8	0.8	1.0	-1.2	0.9	1.0	-0.4	0.8	0.9	1.0	0.6	1.0	1.0	1.2
Overall health rating	0.4	0.9	2.9	-1.7	-1.0	-0.6	-1.4	0.3	-1.0	-1.1	-1.0	-0.1	-1.1	-0.8	-0.6	-1.5	-1.0	-1.0	-1.1	0.2	-0.5	-0.9
Illnesses of siblings: Diabetes	0.4	0.5	2.4	0.6	0.0	1.6	1.3	-0.3	0.3	0.3	0.5	-0.1	0.3	0.3	-0.8	0.3	0.4	0.5	-0.1	0.3	1.2	1.0
Illnesses of father: None of the above (group 1)	0.4	0.5	3.9	0.3	0.9	1.2	0.5	2.0	0.3	0.2	0.6	0.4	0.3	0.3	-0.6	0.8	0.3	0.6	0.5	0.7	0.6	0.7
Arm fat mass (left)	0.4	1.7	3.6	-1.0	-1.1	-0.5	-0.8	-0.6	-1.3	-1.4	-1.2	0.9	-1.3	-1.2	-1.8	-1.6	-1.4	-1.2	-1.1	-1.9	-1.6	-1.6
Medication: Paracetamol	0.4	0.6	1.1	-0.8	0.5	0.0	0.7	-0.6	1.0	0.9	1.1	-0.7	1.0	1.0	-0.8	-0.0	0.8	1.1	-0.3	0.7	0.4	0.8
Medication: Lisinopril	0.4	0.5	3.7	-0.9	0.1	-0.3	1.1	-0.3	0.4	0.6	0.8	-1.9	0.5	0.5	-0.3	-0.4	0.5	0.8	-0.0	0.5	0.1	0.6
Leg fat percentage (left)	0.4	1.6	3.5	1.0	1.5	0.9	1.9	0.2	1.6	1.6	1.7	-0.7	1.6	1.7	-0.9	1.1	1.4	1.7	1.3	0.3	0.1	0.8
Myopia	0.4	0.6	1.6	-0.5	-0.6	-1.3	-1.1	-0.2	-0.9	-0.8	-0.8	0.4	-0.8	-0.6	-0.8	-0.5	-0.8	-0.8	-0.8	-0.1	-0.2	-0.9
Pain experienced in last month	0.4	0.7	2.5	-0.1	0.6	1.6	0.7	-0.3	0.6	0.7	0.5	-0.8	0.6	0.5	1.4	0.7	0.8	0.5	0.8	1.3	1.0	1.0
Leg fat mass (left)	0.4	1.7	4.9	-1.0	-0.9	-0.4	-0.6	-0.8	-1.1	-1.2	-1.1	0.7	-1.2	-1.0	-1.9	-1.5	-1.3	-1.1	-1.0	-2.2	-1.9	-1.7
Intelligence (Savage-Jansen 2018)	0.3	0.8	2.3	-0.6	-0.7	-1.1	0.3	-0.9	-0.6	-0.5	-0.9	-0.3	-0.6	-0.7	-0.3	-0.9	-0.8	-0.9	-1.1	-1.3	-1.4	-1.5
Irritable Bowel Disease (IBD)	0.3	0.6	1.7	0.2	0.7	1.1	0.7	1.2	0.8	0.7	0.5	-1.1	0.6	0.7	1.0	0.3	0.7	0.5	0.6	1.1	1.3	0.4
Reaction Time	0.3	0.6	1.0	0.3	0.5	0.7	1.0	-0.8	0.9	0.9	1.0	0.1	0.9	0.9	0.6	0.7	0.9	1.0	0.7	0.7	0.3	1.0
Bipolar Disorder (2011)	0.3	0.3	1.8	-0.5	-0.0	-0.1	-0.7	0.5	-0.2	-0.2	-0.2	-0.6	-0.2	-0.2	0.2	-0.6	-0.4	-0.2	-0.4	-0.5	-1.3	-0.7
Body Mass Index (BMI) (2010)	0.3	0.4	1.8	-1.3	0.0	0.9	-0.2	0.9	-0.7	-0.7	-0.6	-1.2	-0.6	-0.6	0.7	-0.3	-0.6	-0.6	0.1	-0.2	-0.1	0.0
Lupus	0.3	0.4	2.6	0.5	0.4	-0.3	-0.2	0.3	-0.2	-0.2	0.3	-0.6	-0.0	-0.0	-0.9	0.1	0.0	0.2	0.3	1.6	1.6	0.9
Neuroticism (2016)	0.3	0.4	4.0	0.3	0.5	0.7	0.0	2.0	0.5	0.3	0.6	-0.7	0.3	0.4	0.1	0.4	0.4	0.7	0.4	0.2	1.1	0.3
Heel T-Score	0.3	2.4	4.4	-1.6	-1.5	1.1	-1.4	0.1	-2.0	-1.9	-2.1	0.6	-1.9	-2.0	0.4	-1.2	-1.9	-2.1	-0.8	-1.5	-1.7	-1.1
Lung FVC	0.3	1.5	4.1	1.4	1.1	1.1	0.8	0.4	0.6	0.9	0.9	-0.8	0.9	0.8	1.5	1.7	1.1	0.9	1.4	1.6	2.0	1.5
Neuroticism	0.3	0.7	3.5	-0.5	0.7	0.6	0.7	1.7	0.6	0.4	0.5	-1.4	0.4	0.5	1.9	0.4	0.4	0.5	0.2	0.4	1.2	0.4
Frequency of depressed mood in last 2 weeks	0.3	0.4	1.0	-0.7	-0.1	-0.9	-0.5	0.9	-0.6	-0.7	-0.5	-0.2	-0.7	-0.5	-0.6	-0.7	-0.8	-0.5	-0.9	-0.7	-0.8	-1.0
Systolic blood pressure, automated reading	0.3	0.8	4.5	-1.4	-0.3	-1.3	0.4	-2.1	0.1	0.2	0.1	-1.3	0.2	0.3	-1.6	-0.8	0.0	0.1	-0.9	-0.4	-1.0	-0.5
Medication: Co-codamol	0.3	0.3	2.5	-0.7	-0.1	-0.6	-0.7	-0.1	-0.0	-0.0	0.1	0.4	-0.1	-0.1	-0.5	-0.3	-0.2	0.1	-0.4	-0.7	-1.6	-0.8
Fed-up feelings	0.3	0.5	3.2	0.0	0.9	0.5	0.2	1.8	0.6	0.6	0.7	-1.4	0.6	0.8	0.3	0.4	0.6	0.7	0.4	0.1	0.1	0.1
Taking other prescription medications	0.3	0.5	1.8	-0.6	-0.8	-0.2	-1.3	-1.2	-0.5	-0.5	-0.4	1.0	-0.5	-0.5	-0.5	-1.0	-0.5	-0.4	-0.6	-0.7	-0.4	-0.6
Had menopause	0.3	0.4	1.3	0.1	0.2	0.5	0.9	-0.8	0.6	0.5	0.7	-0.3	0.6	0.6	-0.5	-0.1	0.6	0.7	0.4	1.1	1.1	0.7
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	2.2	0.7	0.5	-0.3	0.9	0.4	0.4	0.6	0.8	-1.5	0.6	0.6	-0.3	-0.0	0.5	0.8	0.2	-0.3	-0.1	0.1
Illnesses of siblings	0.3	0.4	0.9	0.4	0.7	-0.1	-0.3	0.2	1.0	1.0	0.6	-0.2	0.9	0.9	0.1	0.6	0.8	0.6	0.9	0.4	-0.5	0.0
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	2.2	-0.3	-0.4	-0.1	-1.5	1.4	-0.2	-0.5	-0.7	0.5	-0.5	-0.5	0.4	-0.6	-0.5	-0.7	-0.8	-0.4	-0.4	-0.7
Noisy workplace	0.3	0.3	2.7	-1.6	0.1	1.2	-0.5	0.6	-0.3	-0.4	-0.4	0.1	-0.3	-0.3	0.2	-0.4	-0.3	-0.4	0.1	-0.2	-0.4	-0.0
Medication: Lansoprazole	0.3	0.3	1.2	0.6	0.3	0.0	0.4	-0.0	0.6	0.6	0.6	0.4	0.6	0.6	-0.5	0.5	0.7	0.6	0.0	0.7	1.1	0.9
Prospective memory result	0.3	0.4	3.2	-0.5	-0.3	-0.1	-0.4	-1.8	0.0	-0.1	-0.1	-1.6	-0.1	-0.1	0.3	-0.1	-0.2	-0.1	-0.7	-0.9	-0.3	-0.5
Lung cancer (father)	0.3	0.4	1.8	0.7	-0.7	-0.3	-1.0	-1.0	-0.4	-0.3	-0.3	1.3	-0.4	-0.3	-1.1	-0.5	-0.3	-0.3	0.1	0.4	-0.1	0.0
Pulse wave Arterial Stiffness index	0.3	0.3	1.5	-0.8	0.6	-0.6	-0.2	1.2	-0.1	-0.2	0.1	-0.6	-0.1	-0.0	-1.2	-0.1	-0.2	0.1	0.3	-1.2	-0.2	-0.4
Exposure to tobacco smoke at home	0.3	0.3	1.6	-0.3	-0.3	-1.3	-0.5	-0.6	-0.3	-0.5	-0.5	-0.4	-0.5	-0.4	-0.5	-0.6	-0.5	-0.5	-0.1	-0.6	-1.1	-0.3
Pulse wave reflection index	0.3	0.4	1.4	-0.7	-0.0	0.3	-0.7	1.2	-0.6	-0.7	-0.6	0.4	-0.7	-0.7	-1.0	-0.4	-0.7	-0.6	0.2	-0.8	-0.2	-0.7
Number of children fathered	0.3	0.3	2.5	-0.5	0.0	1.4	0.1	0.4	0.5	0.3	0.3	0.7	0.2	0.2	1.6	-0.2	0.2	0.3	0.3	-0.1	-0.4	0.3
Emphysema/chronic bronchitis	0.3	0.3	1.8	0.6	0.1	1.4	-0.4	-0.7	-0.1	-0.0	0.4	0.3	0.0	0.1	-0.1	0.4	0.2	0.4	0.0	0.7	1.0	1.1
Age at last live birth	0.3	0.5	5.0	-1.2	0.2	-0.3	0.2	-0.4	-0.0	0.0	0.1	-2.2	0.0	-0.0	0.4	-0.1	-0.0	0.1	-0.3	-1.0	-0.7	-0.3
Leg pain on walking	0.3	0.4	1.3	0.7	0.6	-0.7	-0.2	-0.0	0.6	0.7	0.6	-1.1	0.7	0.8	-0.3	0.2	0.5	0.6	0.6	-0.5	-0.6	-0.6
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	2.0	-0.7	0.4	0.3	0.4	-0.2	0.7	0.7	0.4	-0.2	0.7	0.6	0.4	0.3	0.7	0.4	0.6	1.4	0.5	0.8
Average weekly red wine intake	0.3	0.4	4.8	-0.2	0.5	0.5	-0.3	2.2	-0.4	-0.3	-0.5	0.1	-0.3	-0.4	0.9	0.1	-0.3	-0.5	0.6	0.4	0.1	-0.1
Long-standing illness, disability or infirmity	0.3	0.5	2.2	-0.7	-0.4	-0.9	-1.3	-0.3	-0.3	-0.3	-0.1	-0.5	-0.3	-0.2	-1.5	-0.9	-0.4	-0.1	-0.9	-0.3	-0.6	-0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	1.3	-0.7	1.1	0.3	-0.5	-0.1	0.3	0.3	0.7	-0.1	0.3	0.3	-0.3	0.7	0.3	0.7	1.1	0.0	-0.5	0.4
Qualifications: nursing, teaching	0.3	0.4	1.1	0.0	0.7	0.2	0.3	-0.0	0.6	0.6	0.6	-0.9	0.6	0.5	1.1	0.5	0.7	0.6	0.3	1.0	0.7	0.9
Miserableness	0.3	0.5	3.3	1.3	0.6	0.4	-0.4	1.8	0.1	0.1	0.2	0.0	0.1	0.3	0.1	0.3	0.3	0.2	0.3	0.8	1.6	0.2
Guilty feelings	0.3	0.4	3.4	0.3	0.3	0.7	0.8	1.0	0.3	0.3	0.3	-0.9	0.3	0.3	1.8	0.4	0.3	0.3	-0.0	0.5	0.7	0.5
Mother’s age at death	0.3	0.3	0.9	-0.9	-0.2	0.7	0.4	0.7	-0.6	-0.6	-0.6	0.2	-0.5	-0.5	-0.8	-0.4	-0.5	-0.6	-0.5	-0.5	1.0	-0.4
Age started oral contraceptive pill	0.3	0.3	2.2	-0.6	0.2	-0.5	0.1	-0.6	0.2	0.2	0.4	-1.5	0.2	0.1	-0.6	-0.9	0.2	0.4	-0.1	0.8	0.6	0.5
Diastolic blood pressure, automated reading	0.3	0.8	4.0	0.1	0.6	-0.2	2.0	-1.2	1.0	1.0	0.9	-0.4	1.1	1.2	-1.4	0.1	0.9	0.9	0.4	0.3	-0.8	0.5
Ever depressed for a whole week	0.3	0.4	1.1	1.0	0.6	0.2	1.0	0.9	0.4	0.5	0.8	-1.1	0.5	0.4	-0.2	0.5	0.5	0.8	0.3	0.4	0.8	0.7
Alcohol drinker status: Previous	0.3	0.4	2.3	0.5	0.3	0.5	0.4	-0.4	0.5	0.5	0.5	-1.5	0.5	0.4	0.6	0.2	0.5	0.5	0.7	0.6	0.6	0.7
Neuroticism (Nagel 2018)	0.2	0.5	4.1	-0.5	0.6	0.9	0.6	2.0	0.4	0.2	0.3	-1.1	0.2	0.4	0.9	0.1	0.3	0.3	-0.1	0.1	0.8	0.2
Worry (Nagel 2018)	0.2	0.5	3.3	0.1	0.1	0.9	1.3	0.5	0.4	0.3	0.2	-0.7	0.3	0.4	1.8	0.4	0.4	0.2	-0.3	0.3	0.7	0.5
Breast Cancer	0.2	0.5	2.3	-0.1	0.6	-1.5	0.5	0.2	0.8	1.0	0.6	-0.8	0.9	0.8	0.9	0.3	0.7	0.5	0.3	-0.1	-1.1	-0.1
HbA1C	0.2	0.2	0.8	0.7	0.4	0.5	-0.4	0.3	0.6	0.6	0.1	0.1	0.6	0.6	-0.9	0.5	0.6	0.0	0.4	0.4	-0.1	0.3
Triglycerides	0.2	0.4	3.7	-0.5	0.1	-1.9	-0.4	0.1	-0.1	-0.1	0.1	-0.0	-0.2	-0.2	1.5	0.3	0.0	0.1	0.1	0.5	0.4	0.3
Blood Red Count	0.2	2.2	7.0	2.2	1.0	2.6	2.2	-0.6	1.8	1.5	1.6	0.0	1.6	1.6	-0.7	1.2	1.5	1.6	1.4	0.8	0.8	1.2
Allergy or Eczema	0.2	0.4	3.0	-1.7	-0.6	-0.5	-0.4	0.4	-0.4	-0.6	-0.7	0.1	-0.6	-0.5	0.1	-1.0	-0.5	-0.8	-0.7	0.2	-0.1	-0.2
Respiratory disease	0.2	0.4	1.0	0.2	1.0	0.5	0.3	0.5	0.9	0.8	0.9	-0.2	0.8	0.8	-0.3	0.8	0.8	0.9	0.2	0.7	0.3	0.6
Chronotype (morning person)	0.2	0.4	1.6	-0.1	0.4	-0.6	0.1	-1.3	0.8	0.7	0.8	-0.8	0.8	0.6	-0.2	0.7	0.7	0.8	0.0	0.2	-0.3	0.1
Vitamin and mineral supplements	0.2	0.2	0.7	-0.6	-0.2	0.5	-0.9	-0.6	-0.3	-0.4	-0.4	0.8	-0.4	-0.4	0.1	-0.3	-0.4	-0.4	0.2	-0.5	-0.3	-0.1
Diabetes (father)	0.2	0.2	1.3	0.6	0.1	-0.5	0.5	0.1	0.1	0.1	-0.2	-0.0	0.1	0.2	-0.6	-0.1	0.1	-0.2	0.0	-0.8	-1.2	-0.6
Maternal smoking around birth	0.2	0.3	2.3	-0.9	-0.5	-0.5	-0.9	-1.5	-0.1	-0.1	-0.2	0.0	-0.2	-0.2	-0.2	-0.1	-0.2	-0.2	-0.3	0.1	-0.4	0.2
Bilateral oophorectomy (both ovaries removed)	0.2	0.3	1.3	0.1	-0.5	0.0	-0.8	0.5	-0.4	-0.4	-0.4	0.8	-0.3	-0.3	-1.1	-0.3	-0.4	-0.4	-0.7	-0.2	-0.1	-0.5
Diverticular disease/diverticulitis (self-reported)	0.2	0.3	1.3	0.3	0.5	0.6	-0.2	0.6	0.3	0.3	0.3	-1.1	0.2	0.2	0.6	0.8	0.3	0.3	0.8	0.3	0.8	0.2
Number of incorrect matches in round	0.2	0.4	1.5	-1.1	-0.4	-0.3	-1.0	-1.2	-0.3	-0.4	-0.4	0.2	-0.4	-0.4	0.8	-0.5	-0.3	-0.4	0.8	-0.1	-0.3	-0.3
Alcohol usually taken with meals	0.2	0.3	2.0	0.1	-0.2	-0.7	-0.0	-1.0	-0.1	-0.1	-0.1	-0.9	-0.1	-0.1	-1.4	0.0	-0.2	-0.1	-0.4	-0.4	-0.7	-0.5
Mouth/teeth dental problems	0.2	0.3	1.5	-0.2	0.1	-0.5	-0.0	1.2	-0.5	-0.5	-0.6	0.9	-0.5	-0.3	-0.4	-0.4	-0.5	-0.6	0.6	-0.4	-0.8	-0.4
Heart attack	0.2	0.2	0.6	-0.1	-0.2	-0.4	-0.8	-0.6	0.1	0.3	0.6	0.3	0.3	0.2	0.1	0.1	0.3	0.6	-0.6	0.5	0.8	0.5
Pain all over the body in last month	0.2	0.2	1.0	-0.8	0.3	0.5	-0.3	-0.5	0.2	0.2	0.3	-1.0	0.2	0.2	0.5	-0.5	0.1	0.3	0.1	0.6	0.0	-0.0
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	1.4	-1.0	0.2	0.0	-0.3	1.2	-0.2	-0.2	-0.4	0.2	-0.1	-0.1	-1.2	-0.1	-0.0	-0.5	0.2	0.7	0.1	0.2
Neuroticism score	0.2	0.3	1.0	-0.1	-0.3	0.0	-0.3	0.8	-0.5	-0.6	-0.6	-0.5	-0.6	-0.5	1.0	-0.2	-0.5	-0.6	-0.6	-0.2	1.0	-0.5
Arm fat percentage (right)	0.2	0.6	1.2	0.5	1.0	0.1	1.0	0.1	1.1	1.0	1.1	-0.6	1.0	1.1	-0.0	0.7	0.9	1.1	0.7	0.1	-0.1	0.6
Alcohol intake versus 10 years previously	0.2	0.3	2.1	-0.2	-0.4	-1.2	0.1	-0.4	-0.4	-0.3	-0.1	-0.8	-0.2	-0.0	-1.5	-0.6	-0.3	-0.1	-0.8	-0.0	-0.3	0.1
Asthma	0.2	0.4	1.0	0.2	0.9	0.2	0.0	0.3	1.0	0.9	1.0	-0.6	0.8	0.8	-0.7	0.1	0.7	1.0	0.3	0.2	-0.1	0.2
Depression (self-reported)	0.2	0.3	1.3	-0.9	-0.1	0.1	-1.1	-0.2	-0.0	-0.0	-0.1	-1.1	0.0	0.0	-0.1	-0.7	0.0	-0.1	-0.7	0.3	1.0	0.1
Arm fat mass (right)	0.2	1.0	2.7	-0.6	-0.7	-0.4	-0.6	-0.6	-0.9	-0.9	-0.9	0.6	-0.9	-0.8	-1.4	-1.2	-1.0	-0.9	-0.9	-1.6	-1.5	-1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	2.2	1.5	0.2	0.4	0.6	-0.6	0.5	0.5	0.4	-0.6	0.5	0.4	-0.1	0.6	0.5	0.4	-0.5	-0.0	0.5	0.3
Hair/balding pattern: Pattern 4	0.2	0.4	1.2	0.3	0.7	1.0	0.5	-0.0	0.6	0.6	0.8	-1.0	0.7	0.7	-0.1	0.2	0.6	0.8	0.6	-0.1	1.1	0.4
Medication: Paracetamol	0.2	0.4	2.1	-1.0	-0.1	-1.2	-0.5	-0.2	0.2	0.1	0.3	0.0	0.1	0.1	-1.5	-0.5	-0.0	0.3	-1.1	0.1	-0.6	-0.2
High blood pressure (siblings)	0.2	0.2	0.5	0.5	-0.5	0.3	0.5	0.2	-0.7	-0.7	-0.3	0.5	-0.7	-0.7	0.1	-0.4	-0.6	-0.3	-0.4	0.2	0.5	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	2.0	-0.3	0.2	-0.6	0.1	0.1	0.5	0.5	0.1	-0.4	0.5	0.4	1.0	0.1	0.5	0.1	-0.5	0.9	1.4	0.3
Wheeze or whistling in the chest in last year	0.2	0.3	2.9	0.4	0.3	0.3	-1.2	-0.3	0.1	0.1	0.3	0.4	0.1	0.3	-1.7	-0.5	0.1	0.3	0.7	0.2	0.6	0.3
Heart disease (mother)	0.2	0.2	1.3	-0.9	-0.4	-0.7	-0.4	0.1	0.2	0.1	0.0	0.4	0.0	0.1	1.1	-0.6	-0.0	0.0	-0.6	0.0	-0.1	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.9	0.1	0.5	0.5	0.6	0.2	0.6	0.6	0.2	-0.1	0.5	0.5	0.6	0.1	0.4	0.1	0.9	-0.0	-0.4	0.0
Leg fat mass (right)	0.2	0.9	3.2	-0.7	-0.6	-0.1	-0.4	-0.5	-0.8	-0.9	-0.8	0.4	-0.8	-0.7	-1.8	-1.2	-0.9	-0.8	-0.6	-1.8	-1.4	-1.3
Number of full sisters	0.2	0.2	0.9	0.5	0.3	0.8	-0.6	0.9	-0.2	-0.2	-0.2	0.7	-0.2	-0.2	-0.4	0.0	-0.2	-0.2	0.2	-0.2	0.5	-0.1
Family relationship satisfaction	0.2	0.3	1.1	0.8	0.4	-0.6	-0.2	0.7	0.4	0.4	0.5	-0.5	0.4	0.4	-0.4	0.6	0.3	0.5	-0.3	1.0	0.6	0.2
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	1.4	0.3	0.5	-0.2	-0.2	0.2	0.5	0.4	0.6	0.6	0.4	0.4	-1.2	0.6	0.5	0.6	0.5	0.6	0.3	0.7
Supplements: Vitamin C	0.2	0.2	2.5	0.1	-0.1	-0.5	0.5	-0.5	0.1	0.1	0.2	-1.6	0.0	-0.0	-0.3	-0.4	0.1	0.2	-0.3	0.0	0.8	-0.0
Commuting to job workplace: Walk	0.2	0.2	1.2	-0.1	0.1	-1.1	0.2	-0.3	0.1	0.3	0.5	-0.7	0.2	0.2	-0.5	0.0	0.3	0.5	0.4	0.2	-0.6	0.6
Mineral and other dietary supplements	0.2	0.3	2.0	-1.0	-0.4	-0.3	-1.1	-1.4	-0.0	-0.1	-0.2	0.6	-0.1	-0.1	0.5	-0.4	-0.1	-0.2	-0.1	-0.2	-0.2	-0.2
Breast cancer (self-reported)	0.2	0.3	1.2	0.7	-0.4	0.0	-1.1	0.7	-0.3	-0.4	-0.1	0.7	-0.4	-0.5	-0.5	0.1	-0.4	-0.1	-0.4	0.8	0.8	-0.2
Asthma (self-reported)	0.2	0.4	0.9	-0.2	0.8	0.2	-0.1	0.1	0.9	0.8	0.9	-0.9	0.8	0.8	-0.6	-0.1	0.6	0.9	0.2	0.2	-0.2	0.2
Medication: Gliclazide	0.2	0.2	2.4	0.2	-0.4	0.3	0.3	-1.6	-0.1	0.1	0.1	-0.1	0.0	-0.0	1.0	-0.1	0.1	0.1	0.2	-0.3	0.1	-0.0
Financial situation satisfaction	0.2	0.3	1.7	0.4	-0.5	0.8	-0.1	-0.4	-0.1	-0.1	-0.1	0.8	-0.1	-0.1	-1.3	-0.1	-0.0	-0.1	0.4	0.8	0.6	0.5
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.8	-0.4	-0.5	0.2	-0.3	0.3	-0.0	-0.1	-0.4	0.8	-0.1	-0.2	-0.9	-0.6	-0.2	-0.4	-0.5	-0.6	-0.1	-0.4
Supplements: Fish oil (including cod liver oil)	0.2	0.3	1.6	0.6	0.6	-0.3	0.6	1.0	0.1	0.1	0.3	-1.3	0.2	0.3	-0.8	0.4	0.2	0.3	-0.1	0.5	0.5	0.3
Illnesses of father: High blood pressure	0.2	0.2	0.7	-0.1	0.2	0.5	-0.5	-0.4	0.0	0.2	0.2	-0.9	0.1	0.1	-0.7	-0.1	0.2	0.2	0.4	0.8	0.8	0.7
Irritability	0.2	0.3	2.2	-0.6	0.3	1.0	0.0	1.5	-0.5	-0.4	-0.2	-1.2	-0.4	-0.3	0.2	-0.3	-0.4	-0.2	0.0	-0.3	0.3	-0.4
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.7	-0.2	-0.8	-0.8	-0.4	0.1	-0.4	-0.3	-0.6	0.5	-0.4	-0.5	0.7	-0.4	-0.4	-0.6	-0.3	0.4	0.0	-0.6
Cholesterol lowering medication	0.2	0.3	1.3	0.6	-0.1	0.5	0.1	0.2	0.0	0.0	-0.1	1.1	0.0	0.1	1.0	0.6	0.1	-0.1	0.3	1.1	0.5	0.3
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	1.0	-1.0	0.3	-0.1	-0.1	0.3	0.6	0.5	0.6	-0.8	0.5	0.4	-0.3	0.1	0.5	0.6	-0.3	0.5	0.6	0.4
Basal cell carcinoma (self-reported)	0.2	0.2	2.6	-0.1	0.2	-0.0	0.4	-0.4	0.3	0.3	0.0	-1.6	0.3	0.1	0.3	-0.2	0.3	0.0	0.3	0.1	-0.4	0.1
Heart attack/myocardial infarction (self-reported)	0.2	0.2	1.0	-0.2	-0.4	-0.5	-1.0	-1.0	-0.1	0.0	0.4	0.3	-0.0	-0.1	0.3	-0.1	0.0	0.4	-0.7	0.2	0.5	0.3
Depression (Nagel 2018)	0.1	0.2	1.4	-1.2	0.6	-0.1	0.2	1.0	0.2	0.1	0.2	-0.2	0.1	0.2	0.5	-0.2	-0.0	0.2	-0.2	-0.6	-0.3	-0.6
Major Depression (MDD)	0.1	0.1	0.8	-0.0	-0.3	-0.6	-0.3	-0.2	-0.2	-0.3	0.1	0.6	-0.2	-0.2	0.5	-0.3	-0.3	0.1	0.2	-0.3	0.9	-0.5
Verbal and Numeric Reasoning (VNR)	0.1	0.3	1.1	-0.2	-0.4	-1.1	-0.2	-0.1	-0.6	-0.5	-0.5	0.4	-0.5	-0.7	-0.0	-0.1	-0.6	-0.5	-0.5	-0.7	-0.2	-0.7
Age at First Birth	0.1	0.2	0.9	0.1	-0.3	0.1	-0.5	-0.9	-0.3	-0.3	-0.3	-0.6	-0.3	-0.3	-0.1	0.0	-0.2	-0.3	-0.1	0.5	0.7	0.1
LDL Cholesterol	0.1	0.2	1.1	-1.0	0.3	-0.1	-1.1	-0.7	0.2	0.1	-0.4	-0.8	0.2	0.1	0.1	-0.4	0.2	-0.4	-0.4	0.3	0.2	0.2
Rheumatoid Arthritis	0.1	0.1	1.3	-0.3	0.0	-0.3	-0.0	-1.1	0.2	0.2	0.3	-0.5	0.1	0.2	0.3	0.0	0.1	0.2	0.1	0.1	0.5	-0.1
Schizophrenia (2014)	0.1	0.3	2.2	0.4	0.5	-0.2	-0.6	1.5	0.1	0.1	0.1	0.7	0.1	0.2	-1.0	0.2	0.1	0.1	0.5	-0.1	0.4	-0.3
Ulcerative Colitis	0.1	0.1	0.6	-0.5	-0.2	-0.2	-0.2	0.1	-0.1	-0.2	-0.3	-0.5	-0.4	-0.3	-0.1	-0.2	-0.4	-0.3	-0.3	0.2	0.7	-0.8
Blood Eosinophil Count	0.1	1.0	4.0	-0.2	0.8	0.9	0.6	-0.0	1.1	0.9	1.0	0.1	0.9	1.1	0.3	0.8	1.1	1.0	1.0	1.6	2.0	1.7
Blood White Count	0.1	0.4	3.6	0.9	0.0	-1.4	0.0	-0.5	0.3	0.2	0.3	1.9	0.2	0.3	0.7	0.1	0.2	0.3	0.0	-0.0	0.6	0.1
BMI	0.1	0.8	2.0	0.8	0.6	1.0	1.3	-0.3	1.1	1.0	1.0	-0.3	1.0	1.1	-1.4	0.4	0.8	1.0	0.7	-0.2	-0.8	0.3
Systolic Blood Pressure	0.1	0.4	2.2	0.0	0.0	-1.5	-0.4	-0.8	0.3	0.3	0.3	-0.1	0.4	0.5	-1.2	-0.5	0.2	0.3	-0.8	-0.4	-1.3	-0.5
Tanning	0.1	0.8	2.1	1.0	1.0	0.5	0.8	0.3	0.9	0.8	0.9	-0.3	0.8	0.8	0.6	0.9	0.9	0.9	0.8	1.4	1.4	1.2
Average weekly spirits intake	0.1	0.2	1.7	-0.2	0.3	-0.0	-1.3	0.3	0.1	0.1	0.3	0.3	0.2	0.2	0.3	-0.5	0.1	0.3	0.7	-0.1	0.3	-0.0
Trunk fat percentage	0.1	0.3	1.3	-0.2	-0.2	-1.1	0.5	-0.6	-0.0	-0.1	0.1	-0.1	-0.1	-0.0	-1.0	-0.3	-0.2	0.1	-0.5	-0.9	-0.9	-0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.1	1.6	0.0	0.0	1.2	-0.2	0.1	-0.4	-0.3	-0.3	-0.1	-0.4	-0.4	-0.4	0.3	-0.3	-0.3	-0.0	-0.0	0.1	0.1
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.9	-0.9	0.3	0.6	0.1	0.4	0.3	0.2	0.1	-0.3	0.2	0.2	0.1	-0.2	0.2	0.1	0.4	0.7	0.5	0.6
Body mass index (BMI)	0.1	0.3	1.3	0.1	0.3	0.9	0.5	0.5	0.1	0.0	0.1	0.4	0.1	0.2	-1.1	-0.2	-0.0	0.1	0.2	-0.9	-1.0	-0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.1	1.1	0.1	0.4	1.1	-0.4	0.4	0.0	0.0	0.1	-0.4	-0.0	0.0	0.5	0.6	0.0	0.1	0.3	0.3	-0.1	0.4
Qualifications: None of the above	0.1	0.2	0.5	0.7	0.7	0.4	-0.4	0.3	0.4	0.3	0.6	-0.5	0.3	0.4	-0.1	0.6	0.3	0.6	0.4	0.3	0.3	0.3
Financial difficulties in last 2 years	0.1	0.2	1.1	-0.1	0.0	0.7	0.8	0.4	0.2	0.2	0.4	-1.0	0.2	0.3	-0.1	-0.0	0.1	0.4	-0.2	-0.8	-0.3	0.1
Allergy	0.1	0.1	0.7	0.9	-0.1	-0.5	0.3	-0.2	0.0	0.2	0.1	0.3	0.1	0.1	0.5	0.5	0.1	0.1	0.1	-0.5	-0.6	-0.4
Fluid intelligence score	0.1	0.1	1.0	-0.1	-0.0	-1.0	0.9	-0.4	0.3	0.2	0.0	0.2	0.2	0.1	-0.4	0.3	0.2	0.0	0.2	0.3	0.1	0.1
Hip circumference	0.1	0.2	1.8	0.1	0.3	1.4	0.7	0.0	0.0	-0.0	0.1	-0.5	0.0	0.1	-1.0	0.2	-0.0	0.1	0.4	-0.2	-0.5	-0.1
Falls in the last year	0.1	0.2	0.7	-0.6	0.1	-0.6	0.8	-0.1	0.4	0.2	0.3	-0.4	0.3	0.2	-0.1	-0.1	0.2	0.3	-0.4	0.2	-0.8	0.2
Happiness	0.1	0.1	0.9	0.3	0.2	-0.2	-0.2	-0.1	0.2	0.2	0.1	0.4	0.2	0.2	0.1	0.3	0.2	0.1	0.1	1.0	0.7	0.1
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	1.7	0.3	0.1	0.0	-0.2	0.0	0.2	0.1	0.1	0.1	0.1	0.1	1.3	0.4	0.1	0.1	-0.1	-0.4	0.3	-0.2
Headache pain in last month	0.1	0.2	1.8	-0.0	-0.0	-1.3	-0.1	0.2	0.2	0.1	0.1	0.2	0.1	0.1	-0.8	-0.1	0.1	0.1	-0.0	0.3	0.9	0.4
Body fat percentage	0.1	0.3	1.0	0.3	0.6	-0.3	1.0	-0.0	0.7	0.6	0.8	-0.3	0.7	0.7	-0.7	0.3	0.5	0.8	0.3	-0.4	-0.7	-0.1
Qualifications: College or University degree	0.1	0.2	0.6	-0.6	-0.6	-0.3	0.8	-0.6	-0.5	-0.4	-0.5	0.4	-0.5	-0.5	0.5	-0.5	-0.3	-0.5	-0.2	0.0	-0.1	0.1
Pulse rate, automated reading	0.1	0.2	0.7	-0.4	-0.5	-0.8	0.6	-0.6	-0.1	-0.2	-0.4	0.8	-0.2	-0.0	0.3	-0.8	-0.2	-0.4	-0.3	-0.7	-0.1	-0.5
Comparative height size at age 10	0.1	0.6	1.2	-0.4	-0.8	0.6	-0.4	0.2	-1.0	-1.1	-1.1	0.7	-1.0	-1.0	-0.8	-0.4	-1.0	-1.1	-0.9	-0.5	0.2	-0.9
Chest pain or discomfort	0.1	0.2	1.2	0.8	0.4	0.7	0.4	1.1	0.0	0.2	0.3	-0.1	0.1	0.2	-0.6	0.1	0.1	0.3	0.7	0.4	0.3	0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.2	0.9	0.0	0.6	-0.6	-0.2	1.0	0.4	0.3	0.2	0.4	0.4	0.4	-0.5	0.2	0.3	0.2	0.1	-0.5	-0.0	-0.1
Arm fat percentage (left)	0.1	0.5	1.0	0.6	0.8	0.2	1.0	0.0	1.0	0.9	0.9	-0.5	0.9	1.0	-0.4	0.5	0.8	0.9	0.7	0.0	-0.2	0.5
Mood swings	0.1	0.2	0.6	0.3	-0.1	-0.2	-0.6	0.7	-0.3	-0.5	-0.5	0.5	-0.4	-0.3	0.2	-0.2	-0.4	-0.5	-0.7	-0.0	0.6	-0.6
Medication for cholesterol	0.1	0.2	1.1	-0.0	0.3	0.2	-0.3	-1.1	0.2	0.3	0.4	-1.0	0.3	0.3	0.2	0.0	0.3	0.4	0.3	0.0	0.7	0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	1.8	-0.4	-0.2	-1.3	-0.6	0.2	-0.5	-0.3	-0.4	-0.1	-0.3	-0.3	0.3	-0.4	-0.3	-0.4	-0.3	0.2	-0.2	-0.4
Medication: Blood pressure	0.1	0.1	0.6	0.6	-0.2	-0.4	0.6	0.2	-0.1	-0.0	-0.1	0.4	-0.0	0.0	0.5	0.0	-0.1	-0.1	-0.3	-0.3	-0.8	-0.5
Average weekly beer plus cider intake	0.1	0.1	0.6	-0.1	0.1	0.8	0.1	-0.6	0.0	0.0	0.0	-0.5	0.0	0.1	-0.5	0.1	0.0	0.1	0.3	-0.1	0.4	0.5
Ulcerative Colitis (UC)	0.0	0.1	0.5	-0.4	0.2	0.0	0.2	0.2	0.1	0.2	0.0	-0.6	0.0	0.1	0.7	0.0	0.0	0.0	0.2	0.3	0.3	-0.3
Lung FEV1/FVC ratio	0.0	0.2	0.6	-0.7	-0.5	-0.6	-0.5	0.1	-0.3	-0.6	-0.4	0.1	-0.5	-0.4	0.5	-0.4	-0.4	-0.3	-0.6	0.5	0.6	0.1
Hair Pigment	0.0	0.7	3.5	-0.3	0.8	-0.0	0.4	1.9	0.8	0.9	1.0	-0.1	0.9	1.0	0.6	0.4	0.8	1.0	0.9	0.8	1.0	0.7

Hub : Genes

AKR1C2

Models

Trait associations