Best TWAS P=2.38e-14 · Best GWAS P=1.87e-11 conditioned to 0.795
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | PLEKHA1 | 0.14 | 0.06 | lasso | 2 | 0.03 | 2.4e-03 | 6.7 | -6.8 | 1.3e-11 | -0.99 | 0.01 | 0.99 | FALSE |
| 2 | GTEx | Muscle Skeletal | PLEKHA1 | 0.10 | 0.04 | lasso | 3 | 0.04 | 8.2e-05 | -6.5 | -5.8 | 5.7e-09 | -0.68 | 0.05 | 0.94 | FALSE |
| 3 | GTEx | Nerve Tibial | PLEKHA1 | 0.22 | 0.23 | enet | 17 | 0.19 | 1.1e-13 | 6.7 | -6.3 | 3.7e-10 | -0.97 | 0.01 | 0.99 | FALSE |
| 4 | GTEx | Skin Sun Exposed Lower leg | PLEKHA1 | 0.16 | 0.02 | lasso | 5 | 0.01 | 4.0e-02 | -6.4 | -6.6 | 3.8e-11 | -0.61 | 0.05 | 0.89 | FALSE |
| 5 | METSIM | Adipose | PLEKHA1 | 0.05 | 0.03 | lasso | 4 | 0.04 | 3.6e-07 | 6.7 | -7.6 | 2.4e-14 | -0.86 | 0.01 | 0.99 | TRUE |
| 6 | ROSMAP | Brain Pre-frontal Cortex | PLEKHA1 | 0.06 | 0.05 | lasso | 4 | 0.05 | 1.3e-06 | -6.5 | -6.5 | 9.1e-11 | -0.77 | 0.03 | 0.97 | FALSE |
| 7 | The Cancer Genome Atlas | Brain Lower Grade Glioma | PLEKHA1 | 0.04 | 0.05 | lasso | 2 | 0.04 | 4.3e-05 | 6.7 | -6.6 | 3.3e-11 | -1.00 | 0.01 | 0.99 | FALSE |
| 8 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | PLEKHA1 | 0.08 | 0.06 | blup | 103 | 0.02 | 4.0e-02 | 6.7 | -5.8 | 5.5e-09 | -0.93 | 0.01 | 0.87 | FALSE |
| 9 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ARMS2 | 0.06 | 0.04 | blup | 71 | 0.05 | 4.9e-06 | -6.5 | -5.6 | 1.7e-08 | -0.75 | 0.01 | 0.98 | FALSE |
| 10 | The Cancer Genome Atlas | Thyroid Carcinoma | PLEKHA1 | 0.08 | 0.10 | lasso | 1 | 0.09 | 3.5e-09 | 6.6 | -6.6 | 3.2e-11 | -0.99 | 0.01 | 0.99 | FALSE |