TWAS hub - ARMS2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Brain Lower Grade Glioma	0.0417	0.0217	3.2e-03	0.021	0.004	0.006	NA	0.009	1.7e-03	1.1e-01	5.8e-02	NA	2.7e-02
2	TCGA	Pheochromocytoma and Paraganglioma	0.2330	0.0850	2.7e-05	0.195	0.104	0.168	NA	0.212	3.1e-08	6.2e-05	3.2e-07	NA	7.0e-09
3	TCGA	Prostate Adenocarcinoma	0.0592	0.0242	1.9e-05	0.042	0.051	0.048	NA	0.048	3.3e-05	4.9e-06	7.9e-06	NA	7.9e-06

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Back pain experienced in last month	22.7	33.1	41.3	-6.2	-6.4	-4.4
Hypothyroidism (self reported)	12.3	28.2	40.1	-4.3	-5.1	-6.3
Comparative height size at age 10	8.1	44.4	55.8	-5.2	-7.5	-7.1
Hypothyroidism/myxoedema (self-reported)	8.0	15.6	23.1	-3.0	-3.9	-4.8
Medication: Levothyroxine sodium	6.8	11.5	16.2	-3.0	-3.0	-4.0
Age at last live birth	6.6	9.6	13.1	3.6	3.4	2.0
Arm fat-free mass (right)	6.4	32.9	43.2	-4.5	-5.9	-6.6
Arm predicted mass (right)	6.3	32.0	44.1	-4.4	-5.7	-6.6
Arm predicted mass (left)	6.0	30.4	40.7	-4.2	-5.7	-6.4
Arm fat-free mass (left)	5.9	30.1	41.0	-4.2	-5.7	-6.4
Age at first live birth	5.8	10.3	13.4	3.7	3.5	2.3
Trunk predicted mass	5.6	31.9	45.6	-4.1	-5.8	-6.8
Trunk fat-free mass	5.5	31.8	45.0	-4.1	-5.8	-6.7
Whole body water mass	5.5	31.4	44.8	-4.0	-5.8	-6.7
Whole body fat-free mass	5.3	30.2	42.6	-3.9	-5.7	-6.5
Basal metabolic rate	5.3	29.4	42.3	-3.9	-5.6	-6.5
Hand grip strength (right)	5.0	13.6	15.9	-3.3	-4.0	-3.8
Fasting Glucose	4.9	5.8	6.4	-2.4	-2.5	-2.3
Lung cancer (father)	4.9	5.7	7.3	2.1	2.7	2.4
Friendships satisfaction	4.8	5.9	6.7	2.6	2.3	2.4
Lung FVC	4.7	24.1	52.0	-2.9	-7.2	-3.4
Ever had prostate specific antigen (PSA) test	4.7	5.4	7.6	-2.4	-2.8	-1.8
Weight	4.4	21.5	32.0	-3.2	-4.7	-5.7
Heel T-Score	4.3	33.9	49.4	7.0	5.5	4.7
Eye problems/disorders: Diabetes related eye disease	4.3	4.7	7.0	1.6	2.1	2.6
Leg predicted mass (left)	4.2	22.2	32.6	-3.2	-4.9	-5.7
Leg fat-free mass (right)	4.1	21.7	30.2	-3.3	-4.9	-5.5
Leg predicted mass (right)	4.1	21.8	30.2	-3.3	-4.9	-5.5
Fractured/broken bones in last 5 years	4.1	5.3	9.6	-1.3	-2.2	-3.1
Lupus	3.9	5.9	7.8	2.6	2.8	1.8
Leg fat-free mass (left)	3.9	20.9	31.8	-3.0	-4.7	-5.6
Number of self-reported non-cancer illnesses	3.9	6.7	11.5	-2.0	-3.4	-2.1
Hand grip strength (left)	3.6	9.4	14.4	-2.7	-3.8	-2.6
Birth weight	3.6	7.9	15.4	-2.0	-2.0	-3.9
Bipolar Disorder (2018)	3.4	5.4	8.8	1.3	2.3	3.0
Height	3.4	66.1	116.6	-4.1	-8.0	-10.8
Supplements: Glucosamine	3.4	4.4	7.5	2.7	2.1	1.0
Lung FEV1/FVC ratio	3.3	16.9	33.5	3.3	5.8	2.5
Forced vital capacity (FVC)	3.2	12.5	27.6	-1.2	-5.2	-2.9
Type 2 Diabetes (T2D) (2012)	3.1	3.6	7.0	1.2	1.5	2.6
Standing height	3.1	30.4	50.4	-3.1	-5.6	-7.1
Alzheimer’s Disease (in mother)	3.0	3.6	9.2	0.5	1.1	3.0
Bilateral oophorectomy (both ovaries removed)	3.0	3.5	4.3	-1.6	-1.9	-2.1
Financial difficulties in last 2 years	2.9	3.9	4.4	-1.9	-2.0	-2.1
Bipolar Disorder or Schizophrenia	2.8	6.9	8.5	2.3	2.6	2.9
Neuroticism (2016)	2.8	4.1	5.3	2.3	1.7	2.0
Trunk fat mass	2.8	11.8	18.7	-2.3	-3.4	-4.3
Exposure to tobacco smoke outside home	2.8	3.7	4.3	1.7	1.9	2.1
Knee pain experienced in last month	2.8	4.3	4.9	-1.8	-2.2	-2.2
Asthma (self-reported)	2.8	5.6	5.8	-2.3	-2.4	-2.4
Mean Putamen Volume	2.7	3.1	6.1	-2.5	-1.6	-0.8
Wears glasses or contact lenses	2.7	3.1	4.4	2.0	2.1	0.9
Alcohol intake versus 10 years previously	2.6	3.9	5.7	-2.4	-2.4	-0.3
Forced vital capacity (FVC), Best measure	2.6	9.5	21.5	-0.9	-4.6	-2.5
Medication: Gliclazide	2.6	2.9	5.2	1.5	1.1	2.3
Waist circumference	2.5	9.1	14.7	-2.1	-2.9	-3.8
Asthma	2.5	4.9	5.2	-2.1	-2.2	-2.3
Alcohol intake frequency.	2.5	5.7	8.2	-2.6	-2.9	-1.5
Hip circumference	2.4	10.2	15.2	-2.0	-3.3	-3.9
Medication: Lansoprazole	2.4	2.7	5.1	-1.5	-2.2	-0.9
Whole body fat mass	2.4	10.0	15.0	-2.3	-3.1	-3.9
Long-standing illness, disability or infirmity	2.4	3.7	5.3	-2.3	-2.3	-0.8
Osteoarthritis (self-reported)	2.4	3.1	4.1	1.6	2.0	1.7
Respiratory disease	2.3	5.0	6.0	-2.3	-2.5	-1.9
Arm fat mass (left)	2.3	9.4	14.7	-2.2	-2.9	-3.8
Intelligence (Savage-Jansen 2018)	2.2	6.7	12.6	-1.7	-2.1	-3.5
HDL Cholesterol	2.2	3.7	4.9	-1.7	-2.2	-1.8
Shortness of breath walking on level ground	2.2	2.7	4.8	-1.5	-1.0	-2.2
Breast cancer (self-reported)	2.2	2.6	3.0	1.4	1.6	1.7
Alzheimer’s Disease (including proxy)	2.1	3.1	8.2	0.4	0.9	2.9
Schizophrenia (2014)	2.1	4.7	5.7	2.1	2.0	2.4
Severe depression (siblings)	2.1	2.3	4.9	2.2	1.3	0.6
Fluid intelligence score	2.1	4.4	6.0	-1.7	-2.1	-2.5
Arm fat mass (right)	2.1	8.5	14.5	-1.9	-2.7	-3.8
Tense / ‘highly strung’	2.1	3.4	5.5	1.4	1.7	2.3
Osteoporosis (self-reported)	2.1	2.6	5.4	-2.3	-1.3	-0.9
Pain experienced in last month	2.1	3.4	7.9	1.0	2.8	1.2
Prospective memory result	2.0	2.5	4.9	0.7	1.4	2.2
Diabetes (mother)	1.9	2.4	4.7	0.4	1.5	2.2
Birth weight of first child	1.9	3.5	7.8	-0.7	-1.5	-2.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.9	2.3	5.0	-0.4	-1.3	-2.2
Townsend deprivation index at recruitment	1.8	2.6	4.2	2.0	1.7	0.9
Heel bone mineral density (BMD) T-score, automated (right)	1.8	4.0	6.2	2.5	1.9	1.6
Impedance of arm (right)	1.8	8.2	10.6	3.2	2.8	2.5
Forced expiratory volume in 1-second (FEV1), predicted	1.8	3.7	4.8	-1.6	-2.2	-1.9
Alcohol drinker status: Previous	1.8	2.0	2.4	-1.5	-1.5	-1.2
Leg fat mass (left)	1.8	7.0	10.5	-1.9	-2.6	-3.2
Diabetes (father)	1.7	2.1	3.0	1.0	1.7	1.5
Forced expiratory volume in 1-second (FEV1)	1.7	5.9	13.1	-0.6	-3.6	-2.0
Serious illness, injury or assault of a close relative in last 2 years	1.7	1.9	3.7	1.1	1.0	1.9
Blood Eosinophil Count	1.6	12.3	17.4	-4.2	-3.2	-3.1
Average weekly spirits intake	1.6	2.0	2.3	-1.3	-1.4	-1.5
Hair/balding pattern: Pattern 2	1.6	2.1	3.4	-1.2	-1.8	-1.2
Health satisfaction	1.6	2.1	2.9	1.2	1.7	1.4
Leg fat mass (right)	1.6	6.2	10.2	-1.6	-2.4	-3.2
Medication for cholesterol	1.6	2.4	6.1	-0.6	-0.8	-2.5
Major Depression (MDD)	1.5	1.9	2.4	1.6	1.2	1.3
Medication: Allopurinol	1.5	2.0	3.1	-1.4	-1.8	-0.9
Chronotype (morning person)	1.4	3.3	4.4	2.1	1.9	1.4
Illnesses of siblings	1.4	1.9	2.9	-0.5	-1.6	-1.7
Mother’s age at death	1.4	1.7	2.2	1.4	1.0	1.5
Impedance of leg (right)	1.3	6.2	7.2	2.3	2.7	2.4
Taking other prescription medications	1.3	2.1	3.2	-1.1	-1.8	-1.3
Multivitamins +/- minerals	1.3	1.7	2.0	1.4	1.1	1.4
Number of incorrect matches in round	1.3	2.2	6.1	0.6	0.3	2.5
Happiness	1.3	1.6	3.7	-0.8	-0.5	-1.9
Headache pain in last month	1.3	2.2	5.6	2.4	-0.6	0.8
Glaucoma (self-reported)	1.3	1.5	2.3	0.9	1.5	1.2
Heart disease (mother)	1.3	1.6	2.2	-1.1	-1.2	-1.5
Qualifications: NVQ or HND or HNC or equivalent	1.3	1.6	2.1	-1.1	-1.4	-1.2
Hearing aid user	1.3	1.4	2.0	1.4	0.9	1.3
Schizophrenia (2018)	1.2	2.5	3.5	1.9	1.5	1.4
Primary Biliary Cirrhosis	1.2	1.7	2.1	-1.3	-1.5	-1.1
Heel bone mineral density (BMD) T-score, automated (left)	1.2	2.7	4.9	2.2	1.4	1.1
Qualifications: CSEs or equivalent	1.2	1.6	3.0	1.2	1.7	0.6
Body mass index (BMI)	1.2	5.2	6.4	-1.9	-2.3	-2.5
High blood pressure (siblings)	1.2	1.7	2.9	1.0	1.1	1.7
Supplements: Calcium	1.2	1.3	1.8	-1.3	-1.2	-0.9
Depressed Affect (Nagel 2018)	1.1	2.3	3.5	1.9	1.2	1.4
Crohns Disease (2012)	1.1	1.8	2.7	-1.6	-1.6	-0.1
Number of treatments/medications taken	1.1	2.0	4.2	-0.7	-2.1	-1.1
Trunk fat percentage	1.1	4.5	7.3	-1.3	-2.1	-2.7
Impedance of leg (left)	1.1	5.2	6.6	1.9	2.3	2.6
Impedance of arm (left)	1.1	5.2	6.4	2.5	2.3	2.0
Peak expiratory flow (PEF)	1.1	2.6	3.9	-1.1	-1.6	-2.0
Seen a psychiatrist for nerves, anxiety, tension or depression	1.1	1.4	3.0	0.8	0.6	1.7
Number of full sisters	1.1	1.3	2.5	-1.6	-0.8	-0.9
Alcohol drinker status: Never	1.1	1.3	2.6	-1.6	-1.0	-0.4
Impedance of whole body	1.1	5.4	5.6	2.3	2.3	2.4
Smoking Status	1.0	2.4	3.1	-1.1	-1.8	-1.7
Tinnitus: Yes, but not now, but have in the past	1.0	1.1	1.2	1.1	1.0	1.0
Hayfever/allergic rhinitis (self-reported)	1.0	1.3	1.8	-1.4	-1.1	-1.0
Noisy workplace	1.0	1.2	2.1	0.9	1.4	0.8
Forced expiratory volume in 1-second (FEV1), Best measure	1.0	3.1	7.7	0.1	-2.8	-1.3
Worry too long after embarrassment	1.0	1.6	2.5	1.2	1.6	0.9
Mineral and other dietary supplements	1.0	1.4	1.8	-1.0	-1.1	-1.3
Medication: Atorvastatin	1.0	1.3	2.4	-1.6	-1.2	-0.3
Neuroticism (Nagel 2018)	0.9	2.2	3.4	1.8	1.0	1.4
Ever had hysterectomy (womb removed)	0.9	1.0	2.8	1.7	0.2	0.4
Maternal smoking around birth	0.9	1.4	1.8	-1.1	-1.3	-1.1
Alcohol usually taken with meals	0.9	1.5	3.6	-0.6	-0.7	-1.9
Mouth/teeth dental problems: Bleeding gums	0.9	1.1	2.3	0.3	1.0	1.5
Risk taking	0.9	1.4	2.4	-0.7	-1.5	-1.1
Heart disease (siblings)	0.9	1.1	2.5	0.6	1.6	0.6
Verbal and Numeric Reasoning (VNR)	0.8	1.8	4.2	-0.6	-1.0	-2.0
Age at First Birth	0.8	1.2	1.6	-1.0	-1.0	-1.3
Stomach or abdominal pain in last month	0.8	1.0	2.2	1.0	0.1	1.5
Sitting height	0.8	5.6	8.4	-0.7	-2.8	-2.9
Mouth/teeth dental problems	0.8	1.3	2.2	-1.2	-0.4	-1.5
Allergy	0.8	1.8	1.9	1.3	1.3	1.4
Body fat percentage	0.8	3.3	5.2	-1.2	-1.8	-2.3
Average weekly red wine intake	0.8	1.2	2.0	1.2	1.4	-0.3
Smoking status: Current	0.8	1.3	1.8	-1.2	-1.3	-0.6
Pain type(s) experienced in last month: Hip pain	0.8	1.0	1.4	-1.0	-0.9	-1.2
Supplements: Fish oil (including cod liver oil)	0.8	1.0	2.0	0.6	0.9	1.4
Vitamin and mineral supplements	0.7	0.9	2.0	-1.4	-0.4	-0.7
Medication: Atenolol	0.7	0.9	1.3	-1.0	-0.6	-1.1
Chronic bronchitis/emphysema (father)	0.7	0.8	1.3	0.6	1.1	0.9
Hair/balding pattern: Pattern 3	0.7	1.1	2.4	-0.1	1.5	1.0
Illnesses of mother	0.7	0.9	1.7	-0.8	-0.4	-1.3
Breastfed as a baby	0.7	0.9	1.6	-1.0	-0.4	-1.2
Blood clot in the leg (DVT)	0.7	0.9	1.5	-0.4	-1.2	-1.0
Number of full brothers	0.7	0.8	1.1	0.7	1.0	1.0
Neck or shoulder pain in last month	0.7	1.0	1.4	1.2	0.9	0.9
Medication: Ibuprofen	0.7	0.9	2.5	1.6	0.4	0.0
Leg pain on walking	0.7	0.8	1.5	0.4	1.2	0.9
Arm fat percentage (left)	0.7	2.9	5.0	-1.1	-1.6	-2.2
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.7	0.8	-0.8	-0.9	-0.9
Eye problems/disorders: Glaucoma	0.7	0.8	1.1	0.8	1.1	0.8
Medication: Blood pressure	0.7	1.2	2.5	-0.6	-1.0	1.6
Deep venous thrombosis (DVT) (self-reported)	0.7	0.8	1.4	-0.6	-1.2	-0.8
Ulcerative Colitis	0.6	0.9	2.5	-1.6	-0.5	0.1
BMI	0.6	3.2	4.7	-1.4	-1.8	-2.2
Cardiovascular Disease	0.6	2.0	4.6	-1.1	-2.1	0.4
Hearing difficulty/problems: Yes	0.6	0.9	1.5	-1.0	-1.2	-0.6
Relative age voice broke	0.6	0.9	1.3	1.1	1.2	0.3
Had other major operations	0.6	0.8	1.4	0.9	0.4	1.2
Neuroticism score	0.6	1.3	2.1	1.4	0.8	1.1
Arm fat percentage (right)	0.6	2.2	4.0	-0.8	-1.4	-2.0
Father’s age at death	0.6	0.8	1.3	0.4	1.0	1.2
Number of live births	0.6	0.9	1.3	-1.1	-1.1	-0.5
Pulse wave Arterial Stiffness index	0.6	0.7	0.9	-0.6	-1.0	-0.9
Pulse wave reflection index	0.6	0.7	1.3	0.8	0.5	1.1
Loud music exposure frequency	0.6	0.6	1.7	1.3	0.3	0.2
Wheeze or whistling in the chest in last year	0.6	1.1	1.9	-1.0	-0.7	-1.4
Migraine (self-reported)	0.6	0.7	2.0	0.3	-1.4	-0.4
Suffer from ‘nerves’	0.6	1.0	1.3	1.1	0.7	1.1
Supplements: Vitamin C	0.6	0.7	1.6	0.1	-1.3	-0.6
Diabetes diagnosed by doctor	0.6	1.0	2.6	-0.1	0.6	1.6
Miserableness	0.6	1.0	1.8	1.3	0.9	0.7
Guilty feelings	0.6	0.8	2.0	1.4	0.7	0.4
Leg fat percentage (left)	0.6	2.2	2.4	-1.4	-1.5	-1.6
Worry (Nagel 2018)	0.5	1.1	2.4	0.8	0.4	1.6
Rheumatoid Arthritis	0.5	0.7	1.9	-0.0	-0.2	-1.4
Blood White Count	0.5	3.9	8.0	-2.8	-1.9	0.3
Allergy or Eczema	0.5	1.4	1.4	-1.2	-1.2	-1.2
Systolic blood pressure, automated reading	0.5	1.4	3.1	-1.0	-1.8	-0.4
Current tobacco smoking	0.5	0.8	1.1	-1.0	-1.0	-0.5
Fed-up feelings	0.5	0.8	1.5	1.2	0.6	0.8
Serious illness, injury or assault to yourself	0.5	0.6	0.7	-0.8	-0.8	-0.7
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.3	0.7	1.1	0.1
Pain all over the body in last month	0.5	0.5	1.3	0.4	0.1	1.1
Time employed in main current job	0.5	0.6	0.9	0.8	0.6	-1.0
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.7	1.9	1.4	-0.1	-0.4
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.5	0.5	-0.0	1.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.5	0.9	0.5	0.9	0.7
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.4	-0.0	-0.6	-1.2
Ever depressed for a whole week	0.5	0.6	1.1	1.1	0.6	-0.4
Schizophrenia vs Biploar Disorder	0.4	0.6	0.9	-0.3	-0.9	-0.9
Sensitivity / hurt feelings	0.4	0.7	1.7	-0.5	-1.3	-0.4
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	0.8	-0.9	-0.5	-0.7
Angina	0.4	0.5	1.1	-1.0	0.4	-0.5
Had menopause	0.4	0.5	0.7	0.7	0.8	0.6
Falls in the last year	0.4	0.5	1.3	0.1	-0.3	1.2
Leg fat percentage (right)	0.4	1.6	2.4	-1.0	-1.1	-1.5
Mood swings	0.4	0.7	0.9	0.8	0.6	1.0
Qualifications: nursing, teaching	0.4	0.6	1.0	0.5	0.7	1.0
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	1.9	-0.1	-1.4	-0.2
Medication: Lisinopril	0.4	0.5	1.4	-0.5	-1.2	0.2
Illnesses of father: High blood pressure	0.4	0.5	1.4	0.0	-0.0	1.2
Diastolic blood pressure, automated reading	0.4	1.2	1.8	-1.1	-1.3	-0.8
Myopia	0.4	0.6	1.0	-0.5	-0.8	-1.0
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.3	-1.1	-0.2	-0.1
Crohns Disease (2017)	0.3	0.6	0.9	-1.0	-0.9	0.4
Bipolar Disorder (2011)	0.3	0.3	0.4	0.5	0.6	0.6
Triglycerides	0.3	0.5	0.9	-0.9	-0.5	-0.7
Waist Hip Ratio (WHR)	0.3	1.4	1.9	-1.4	-1.0	-1.1
Systolic Blood Pressure	0.3	1.7	4.2	-0.7	-2.1	0.5
Type 2 Diabetes (T2D) (2018)	0.3	0.6	1.2	-0.6	-0.4	1.1
Supplements: Zinc	0.3	0.4	0.5	-0.6	-0.7	-0.5
Medication: Metformin	0.3	0.4	1.0	-0.1	0.3	1.0
Age when periods started (menarche)	0.3	0.7	1.9	0.5	1.4	-0.3
High blood pressure	0.3	0.9	1.6	-0.1	-1.3	1.0
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	0.9	0.0	-0.3	0.9
Nervous feelings	0.3	0.6	0.7	0.8	0.8	0.7
Heart attack	0.3	0.4	1.2	-1.1	-0.2	-0.1
Diabetes (self-reported)	0.3	0.5	1.3	-0.3	0.2	1.1
Qualifications: A levels/AS levels or equivalent	0.3	0.8	1.7	-0.6	-0.5	-1.3
Length of working week for main job	0.3	0.3	1.0	1.0	-0.1	-0.1
Qualifications: O levels/GCSEs or equivalent	0.3	0.4	1.3	-0.1	0.1	-1.1
Gout (self-reported)	0.3	0.4	1.1	0.4	-0.1	1.0
Medication: Amlodipine	0.3	0.4	1.0	0.5	0.1	1.0
Medication for pain relief, constipation, heartburn	0.3	0.5	1.3	0.0	1.1	0.3
Angina (self-reported)	0.3	0.4	0.8	-0.9	0.5	-0.3
Hypertension (Self-reported)	0.3	0.9	1.8	-0.4	-1.4	0.8
Illnesses of father: None of the above (group 1)	0.3	0.3	1.0	0.1	-0.0	-1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.7	0.9	0.7	-0.9	0.8
Ever taken oral contraceptive pill	0.3	0.3	0.9	0.2	0.1	-0.9
Medication: Paracetamol	0.3	0.4	0.9	0.3	-0.4	-1.0
Commuting to job workplace: Cycle	0.3	0.3	0.6	0.4	0.8	0.4
Vascular/heart problems diagnosed by doctor	0.3	0.8	1.5	0.3	1.2	-0.9
Irritable Bowel Disease (IBD)	0.2	0.6	0.9	-1.0	-0.4	0.8
Ulcerative Colitis (UC)	0.2	0.4	1.0	-1.0	-0.3	0.3
HbA1C	0.2	0.2	0.5	-0.1	-0.7	0.0
Blood Platelet Count	0.2	2.1	2.7	-1.6	-1.5	-1.1
Neuroticism	0.2	0.6	0.9	0.9	-0.1	1.0
Relative age of first facial hair	0.2	0.4	1.1	-0.1	-0.1	-1.1
Medication: Co-codamol	0.2	0.2	0.5	-0.3	0.0	-0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.4	-0.6	-0.6	-0.4
Hayfever, allergic rhinitis or eczema	0.2	0.4	0.6	-0.5	-0.6	-0.8
Medication: Ramipril	0.2	0.3	0.5	-0.4	-0.2	0.7
Pulse rate	0.2	0.4	0.8	-0.4	-0.5	-0.9
Medication: Cholesterol lowering	0.2	0.3	0.8	-0.9	-0.3	0.4
Hair/balding pattern: Pattern 4	0.2	0.4	0.9	-0.5	-0.3	-1.0
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.5	-0.2	-0.0	0.7
Medication: Paracetamol	0.2	0.4	0.7	0.1	-0.8	-0.7
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.6	0.5	0.8	0.4
Number of children fathered	0.2	0.2	0.6	-0.8	-0.1	-0.0
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.4	-0.2	-0.6	-0.4
Pulse wave peak to peak time	0.2	0.2	0.3	0.4	0.6	0.5
Mouth/teeth dental problems: Loose teeth	0.2	0.3	0.6	0.2	0.5	0.8
Medication: Omeprazole	0.2	0.2	0.5	-0.4	-0.3	-0.7
Medication: Seretide 50 evohaler	0.2	0.2	0.4	0.5	0.1	-0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.4	0.4	0.7	-0.0
Overall health rating	0.2	0.4	0.5	-0.7	-0.7	0.4
Chest pain or discomfort	0.2	0.2	0.3	-0.5	-0.4	-0.5
Had major operations	0.2	0.2	0.4	0.6	0.4	-0.4
Family relationship satisfaction	0.2	0.2	0.4	0.6	0.6	-0.1
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.5	0.7	0.3	-0.2
Smoking status: Previous	0.2	0.2	0.4	0.3	-0.5	-0.7
Loneliness, isolation	0.2	0.3	0.6	0.8	0.3	0.6
Ever had bowel cancer screening	0.2	0.2	0.3	-0.5	-0.3	0.4
Financial situation satisfaction	0.2	0.3	0.6	-0.0	-0.5	-0.8
High cholesterol (Self-reported)	0.2	0.4	1.0	-0.2	-0.2	1.0
Number of operations (self-reported)	0.2	0.4	0.5	-0.3	-0.7	-0.7
Average weekly beer plus cider intake	0.2	0.3	0.8	0.2	0.4	0.9
Irritability	0.2	0.4	0.9	0.9	-0.0	0.5
Age started oral contraceptive pill	0.2	0.2	0.4	0.5	0.0	-0.6
Unable to work because of sickness or disability	0.2	0.3	0.8	-0.3	-0.1	0.9
Reaction Time	0.1	0.2	0.3	-0.2	-0.6	0.3
Breast Cancer	0.1	0.1	0.3	-0.5	0.3	0.3
Ovarian Cancer	0.1	0.2	0.3	0.0	0.5	0.5
Prostate Cancer	0.1	0.1	0.2	0.5	-0.4	-0.2
Body Mass Index (BMI) (2010)	0.1	0.1	0.4	0.2	-0.2	-0.6
Coronary Artery Disease (CAD)	0.1	0.1	0.3	-0.1	0.3	0.5
Blood Red Count	0.1	0.7	1.2	0.8	0.6	1.1
Hair Pigment	0.1	3.1	3.5	-1.7	-1.7	-1.9
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.4	0.7	0.1	-0.0
Medication for hormone replacement therapy	0.1	0.1	0.3	0.3	0.2	0.5
Pack years adult smoking proportion	0.1	0.1	0.2	0.3	-0.3	0.4
Average weekly fortified wine intake	0.1	0.1	0.1	0.3	0.1	-0.4
High blood pressure (mother)	0.1	0.1	0.1	0.2	-0.2	0.4
Past tobacco smoking	0.1	0.2	0.4	-0.0	0.5	0.6
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.1	0.3	0.2	0.0	0.6
Medication: Simvastatin	0.1	0.1	0.2	-0.4	0.4	0.4
Worrier / anxious feelings	0.1	0.3	0.4	-0.2	-0.6	0.7
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.5	0.7	-0.0	0.4
Mouth/teeth dental problems: Dentures	0.1	0.2	0.2	0.3	-0.5	0.3
Exposure to tobacco smoke at home	0.1	0.1	0.3	-0.2	0.1	0.5
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.2	-0.2	-0.5	-0.3
Comparative body size at age 10	0.1	0.2	0.3	-0.5	-0.5	-0.4
Qualifications: College or University degree	0.1	0.3	0.8	0.0	-0.0	-0.9
Eye problems/disorders: None of the above	0.1	0.1	0.4	-0.6	-0.0	-0.2
Emphysema/chronic bronchitis	0.1	0.1	0.1	-0.3	-0.2	0.3
Medication: Blood pressure	0.1	0.1	0.2	-0.1	-0.5	-0.4
Mean time to correctly identify matches	0.1	0.2	0.5	-0.2	-0.7	-0.2
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.3	-0.3	0.1	-0.6
Medication: Aspirin	0.1	0.2	0.5	-0.2	0.2	0.7
Illnesses of siblings: Diabetes	0.1	0.1	0.3	-0.6	0.1	0.2
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.2	-0.1	-0.4	0.2
Medication: Aspirin	0.1	0.1	0.2	-0.5	0.1	0.4
Average weekly champagne plus white wine intake	0.1	0.1	0.3	0.1	0.5	-0.2
Commuting to job workplace: Public transport	0.1	0.1	0.1	-0.3	-0.1	-0.3
Medication: Bendroflumethiazide	0.1	0.1	0.2	-0.3	-0.5	-0.3
Ever smoked	0.1	0.1	0.3	0.5	-0.2	-0.1
Cholesterol lowering medication	0.1	0.2	0.6	-0.8	0.0	0.2
Basal cell carcinoma (self-reported)	0.1	0.2	0.2	-0.5	-0.3	0.4
Pack years of smoking	0.1	0.1	0.3	0.4	-0.1	0.5
Depression (Nagel 2018)	0.0	0.0	0.0	0.1	-0.1	-0.0
Alzheimer’s Disease (in father)	0.0	0.0	0.1	-0.1	-0.1	-0.3
LDL Cholesterol	0.0	0.0	0.0	-0.1	-0.1	0.1
Tanning	0.0	0.0	0.0	0.1	-0.2	0.2
Ever used hormone-replacement therapy (HRT)	0.0	0.0	0.1	0.0	0.3	0.1
Hearing difficulty/problems with background noise	0.0	0.1	0.2	0.1	0.1	0.5
Qualifications: None of the above	0.0	0.1	0.1	-0.4	0.1	0.3
Depression (self-reported)	0.0	0.0	0.0	0.1	0.2	0.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.0	0.0	0.1	0.2	-0.0	0.3
Pulse rate, automated reading	0.0	0.1	0.2	0.3	0.4	0.4
Illnesses of father: Heart disease	0.0	0.0	0.1	0.2	0.2	0.2
Commuting to job workplace: Walk	0.0	0.0	0.1	-0.4	-0.1	0.1
Eye problems/disorders: Cataract	0.0	0.0	0.1	0.0	-0.0	-0.3
Medication: Omeprazole (e.g. Zanprol)	0.0	0.0	0.0	0.1	0.1	0.2

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