[Hub]/) : Traits : Leg fat-free mass (left) : ← →

chr12:106,649,988-108,064,952

Best TWAS P=5.31e-10 · Best GWAS P=2.15e-09 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
2	GTEx	Adipose Subcutaneous	RP11-412D9.4	0.22	0.13	lasso	5	0.13	5.1e-11	-5.8	6.2	5.3e-10	-0.96	0.01	0.99	TRUE
13	GTEx	Skin Sun Exposed Lower leg	C12orf23	0.06	0.04	lasso	3	0.03	8.0e-04	-6.0	6.2	7.3e-10	-0.99	0.01	0.99	FALSE
15	GTEx	Thyroid	RP11-412D9.4	0.10	0.10	enet	7	0.12	9.3e-10	5.8	6.1	8.6e-10	-0.96	0.01	0.99	FALSE
10	GTEx	Nerve Tibial	C12orf23	0.09	0.12	enet	10	0.12	1.1e-08	-6.0	6.1	9.7e-10	-0.98	0.00	1.00	FALSE
4	GTEx	Artery Tibial	RP11-412D9.4	0.06	0.05	lasso	3	0.06	2.9e-05	-6.0	6.1	1.0e-09	-0.96	0.01	0.99	FALSE
7	GTEx	Cells Transformed fibroblasts	RP11-412D9.4	0.12	0.10	lasso	4	0.09	2.1e-07	-5.8	6.1	1.1e-09	-0.94	0.01	0.99	FALSE
11	GTEx	Nerve Tibial	RP11-412D9.4	0.18	0.18	enet	11	0.20	5.6e-14	-5.8	6.0	1.6e-09	-0.96	0.01	0.99	FALSE
14	GTEx	Testis	RP11-412D9.4	0.25	0.24	lasso	5	0.20	3.7e-09	-6.0	6.0	1.6e-09	-0.98	0.00	1.00	FALSE
17	The Cancer Genome Atlas	Breast Invasive Carcinoma	MTERFD3	0.02	0.01	lasso	4	0.01	1.3e-03	-5.7	6.0	2.2e-09	-0.91	0.01	0.92	FALSE
5	GTEx	Breast Mammary Tissue	RP11-412D9.4	0.23	0.26	lasso	4	0.26	9.7e-14	-6.0	5.8	5.3e-09	-0.99	0.00	1.00	FALSE
18	The Cancer Genome Atlas	Colon Adenocarcinoma	MTERFD3	0.08	0.06	lasso	6	0.05	7.1e-04	-5.7	5.7	1.4e-08	-0.92	0.01	0.79	FALSE
20	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	C12orf23	0.06	0.05	enet	8	0.05	5.0e-03	-6.0	5.6	1.9e-08	-0.93	0.01	0.75	FALSE
1	GTEx	Adipose Subcutaneous	C12orf23	0.07	0.02	lasso	4	0.02	5.5e-03	-6.0	5.5	3.5e-08	-0.92	0.01	0.96	FALSE
12	GTEx	Pancreas	RP11-412D9.4	0.09	0.06	enet	12	0.06	1.2e-03	-6.0	5.5	4.9e-08	-0.85	0.02	0.96	FALSE
6	GTEx	Breast Mammary Tissue (Female)	RP11-412D9.4	0.20	0.14	lasso	4	0.13	9.0e-05	-6.0	5.4	5.6e-08	-0.97	0.01	0.97	FALSE
8	GTEx	Colon Sigmoid	RP11-412D9.4	0.17	0.06	lasso	3	0.07	1.4e-03	5.3	5.4	8.3e-08	-0.80	0.06	0.68	FALSE
3	GTEx	Artery Tibial	C12orf23	0.15	0.10	enet	21	0.15	8.1e-12	5.7	5.3	1.1e-07	-0.81	0.04	0.96	FALSE
16	The Cancer Genome Atlas	Breast Invasive Carcinoma	C12orf23	0.03	0.05	enet	7	0.05	2.2e-10	5.2	5.3	1.1e-07	-0.83	0.12	0.88	FALSE
19	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	C12orf23	0.03	0.01	blup	50	0.01	2.2e-02	-6.0	5.3	1.5e-07	-0.86	0.01	0.83	FALSE
9	GTEx	Lung	C12orf23	0.04	0.03	lasso	2	0.02	9.9e-03	-5.0	5.2	1.8e-07	-0.78	0.04	0.87	FALSE