Hub : Genes

MTERFD3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0560	0.0240	0.00320	0.032	0.019	0.015	0.024	0.019	7.3e-05	0.0018	0.0053	0.00061	2.2e-03
2	GTEx	Spleen	0.3570	0.1120	0.00610	0.019	NA	0.024	NA	0.083	1.1e-01	NA	0.0790	NA	3.7e-03
3	GTEx	Stomach	0.1840	0.0800	0.00240	0.132	NA	0.047	NA	0.099	7.1e-07	NA	0.0028	NA	1.9e-05
4	TCGA	Breast Invasive Carcinoma	0.0210	0.0107	0.00081	0.014	0.011	0.006	NA	0.012	6.7e-04	0.0024	0.0170	NA	1.3e-03
5	TCGA	Colon Adenocarcinoma	0.0840	0.0480	0.00420	0.063	0.044	0.030	NA	0.050	1.6e-04	0.0015	0.0072	NA	7.1e-04
6	TCGA	Kidney Renal Clear Cell Carcinoma	0.0779	0.0358	0.00200	-0.002	0.022	0.017	NA	0.002	5.9e-01	0.0015	0.0043	NA	2.0e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.3	0.4	1.3	-0.0	0.7	-1.2	-0.7	-0.4	-0.3
Bipolar Disorder or Schizophrenia	0.6	1.4	4.6	1.0	0.4	-2.2	-1.0	-1.0	-0.9
Depressed Affect (Nagel 2018)	0.5	1.1	2.2	0.8	0.6	0.5	1.4	1.5	1.2
Depression (Nagel 2018)	0.3	0.5	2.5	1.6	-0.0	0.6	0.2	-0.1	0.1
Intelligence (Savage-Jansen 2018)	0.4	1.4	2.9	-0.3	0.3	1.2	1.7	1.7	1.0
Neuroticism (Nagel 2018)	0.2	0.6	1.0	1.0	0.5	-1.0	0.5	0.7	0.6
Schizophrenia (2018)	0.5	1.1	3.3	1.4	0.0	-1.8	-0.8	-0.9	-0.3
Schizophrenia vs Biploar Disorder	0.6	0.7	2.4	-0.5	-0.9	-1.5	-0.9	-0.2	0.0
Worry (Nagel 2018)	0.2	0.4	0.7	0.9	-0.4	-0.7	0.6	0.6	0.4
Alzheimer’s Disease (in mother)	2.7	3.1	10.6	-0.0	0.9	-0.0	-2.6	-3.2	-0.7
Alzheimer’s Disease (in father)	1.6	1.7	8.3	-0.8	-2.9	0.8	0.1	0.4	-0.9
Alzheimer’s Disease (including proxy)	2.1	3.1	8.8	-0.1	-0.6	0.2	-2.9	-3.0	-0.8
Crohns Disease (2017)	0.7	1.6	5.2	-0.0	0.1	0.7	2.3	1.9	0.5
Irritable Bowel Disease (IBD)	0.4	0.8	2.6	0.4	0.2	-0.4	1.4	1.6	0.1
Ulcerative Colitis (UC)	0.2	0.3	0.8	0.7	-0.4	-0.9	-0.1	0.1	-0.6
Major Depression (MDD)	0.9	1.0	1.9	1.4	-0.8	-0.7	1.4	1.0	-0.3
Reaction Time	0.4	0.8	2.3	0.9	1.5	-1.2	0.0	0.2	0.4
Verbal and Numeric Reasoning (VNR)	0.6	1.4	3.5	-0.0	1.7	0.5	1.0	0.7	1.9
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Ovarian Cancer	0.7	0.9	2.4	1.6	-0.2	-0.1	-0.3	-0.7	-1.6
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.6	0.9	2.7	-0.6	1.6	0.0	-0.8	-0.5	1.1
Bipolar Disorder (2011)	1.1	1.1	2.1	-0.0	-0.1	-1.4	-1.2	-1.4	-1.1
Body Mass Index (BMI) (2010)	1.4	2.0	5.1	0.1	-1.1	1.1	2.0	2.2	-0.4
Coronary Artery Disease (CAD)	1.5	1.8	4.7	-1.6	-2.2	0.2	-0.0	0.3	-1.8
Crohns Disease (2012)	0.5	0.8	1.8	0.5	-0.4	-0.5	1.3	0.9	-1.3
Mean Putamen Volume	1.4	1.6	4.6	0.9	-0.2	1.5	2.1	1.1	0.8
Fasting Glucose	0.6	0.8	2.1	0.3	-1.4	0.4	0.4	0.3	-1.4
HbA1C	0.8	0.9	1.6	-0.4	-0.2	0.6	-1.2	-1.2	-1.2
HDL Cholesterol	1.3	2.2	4.3	-0.7	-1.6	-0.1	2.1	1.8	-1.5
LDL Cholesterol	0.9	1.4	4.2	0.5	-2.1	-1.8	0.2	0.7	-0.7
Lupus	0.8	1.2	5.1	0.1	-2.2	1.1	0.1	0.5	-0.6
Neuroticism (2016)	1.0	1.4	3.6	1.5	-1.9	-1.6	-0.0	0.2	-0.2
Primary Biliary Cirrhosis	0.2	0.3	0.8	-0.8	0.3	0.0	-0.9	-0.1	-0.7
Rheumatoid Arthritis	0.5	0.7	1.3	-1.0	0.2	-1.1	-1.1	-0.4	-0.7
Schizophrenia (2014)	0.5	1.0	3.6	1.5	0.1	-1.9	-0.2	-0.4	0.0
Triglycerides	1.6	2.6	4.9	-1.7	0.4	-2.0	-2.2	-1.5	-1.1
Type 2 Diabetes (T2D) (2012)	1.6	1.8	3.6	0.3	-1.3	1.9	1.3	0.8	-1.8
Ulcerative Colitis	0.3	0.5	1.1	0.3	-1.0	-0.6	0.4	1.0	-0.2
Blood Eosinophil Count	0.1	0.5	1.3	-0.1	-0.8	1.1	1.0	0.3	0.4
Blood Platelet Count	0.2	2.2	5.9	0.8	0.8	0.3	-1.4	-2.4	1.9
Blood Red Count	0.3	3.3	5.6	1.5	2.4	1.8	-1.9	-2.3	0.4
Blood White Count	0.4	2.6	8.5	-0.2	0.4	1.0	-2.4	-2.9	-0.2
Heel T-Score	1.0	8.1	22.8	-1.0	1.2	3.1	4.8	3.6	1.0
BMI	1.0	5.9	11.6	-1.8	-0.6	3.2	3.4	3.1	-0.1
Height	2.6	50.3	126.1	2.4	-4.2	5.5	11.2	11.0	1.3
Waist Hip Ratio (WHR)	1.9	8.7	22.0	2.5	1.0	-0.4	-3.7	-4.7	-3.0
Systolic Blood Pressure	0.4	2.1	3.4	-1.5	1.6	-1.4	1.3	1.9	0.9
Smoking Status	1.2	2.8	9.4	1.2	-0.4	-3.1	-1.8	-1.4	-0.6
Allergy or Eczema	0.2	0.7	1.6	-0.3	0.7	-0.3	1.3	1.1	0.7
Cardiovascular Disease	1.1	3.5	7.2	-0.9	2.7	-0.5	1.9	2.0	2.3
Hypothyroidism (self reported)	0.2	0.5	2.1	-0.2	-1.4	0.1	0.3	0.3	-0.8
Respiratory disease	0.7	1.4	4.2	1.3	0.5	-0.8	2.1	1.3	0.6
Type 2 Diabetes (T2D) (2018)	0.7	1.3	4.4	-0.2	-1.3	1.0	-0.3	-0.6	-2.1
Lung FEV1/FVC ratio	0.5	2.4	9.9	-3.1	1.1	-0.3	-1.7	-0.5	-0.2
Lung FVC	0.2	1.0	5.2	-0.4	-0.4	0.0	0.4	0.4	-2.3
Neuroticism	0.3	0.6	1.5	1.2	-0.5	-0.8	0.4	1.0	0.6
Chronotype (morning person)	2.3	5.3	27.5	-5.2	0.7	-1.2	0.4	1.5	-0.1
Hair Pigment	0.1	1.5	2.7	-1.6	0.9	-1.3	-1.1	-1.5	-0.6
Tanning	0.3	3.1	6.0	-0.2	-2.5	1.4	2.1	2.2	-1.1
Hand grip strength (left)	1.0	2.7	8.2	-2.9	-1.0	-0.0	1.8	2.0	-0.0
Number of treatments/medications taken	0.1	0.3	0.5	-0.5	0.4	0.5	0.6	0.7	-0.3
Average weekly spirits intake	0.5	0.7	1.3	0.9	0.1	-1.1	-0.7	-0.6	1.1
Sensitivity / hurt feelings	0.6	1.0	3.3	-0.4	1.0	-1.8	-0.7	0.4	-0.9
Frequency of depressed mood in last 2 weeks	0.4	0.6	2.0	1.4	0.8	0.3	-0.5	-0.7	0.1
Hearing difficulty/problems: Yes	0.8	1.2	3.6	-0.8	0.1	1.2	1.9	1.3	0.4
Relative age of first facial hair	1.0	2.1	8.5	-2.9	-0.0	-0.8	-1.4	-1.1	0.1
Other serious medical condition/disability diagnosed by doctor	0.1	0.2	0.4	0.6	-0.6	-0.3	-0.2	-0.1	0.2
Ever used hormone-replacement therapy (HRT)	0.7	0.9	1.4	1.1	1.1	-1.1	0.9	0.1	-1.2
Ever had hysterectomy (womb removed)	0.7	0.8	1.8	0.5	-0.2	-1.0	1.4	1.2	-0.8
Systolic blood pressure, automated reading	1.0	2.9	8.9	-1.2	0.2	-0.9	2.3	3.0	1.1
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	1.5	-0.9	1.2	-1.1	-1.1	-0.8	-0.2
Angina	0.4	0.6	1.4	-1.1	0.2	-0.3	0.8	0.3	-1.2
Medication for hormone replacement therapy	1.0	1.1	4.7	2.2	0.4	1.0	0.7	0.1	-0.7
Vitamin and mineral supplements	0.6	0.8	1.7	0.8	-1.0	1.3	1.0	0.6	0.3
Supplements: Zinc	1.2	1.3	4.7	2.2	1.3	-0.4	-0.5	-1.0	-0.3
Medication: Co-codamol	1.2	1.4	6.0	0.2	-0.5	-0.7	-0.7	-1.1	-2.4
Medication: Metformin	0.7	0.9	3.1	-0.9	-0.5	1.0	-0.2	-0.7	-1.8
Diabetes (father)	0.3	0.4	0.9	-0.5	0.1	0.9	-0.6	-1.0	0.3
Diabetes (mother)	0.5	0.6	1.6	-0.1	1.2	0.3	-0.5	-0.6	-1.3
Severe depression (siblings)	1.1	1.2	2.8	-1.7	0.7	0.9	0.9	1.0	1.1
Pack years adult smoking proportion	0.2	0.3	1.3	0.1	-0.6	1.2	-0.2	-0.4	0.5
Impedance of leg (right)	0.6	2.7	6.8	2.6	-1.2	-0.4	-1.9	-2.1	-0.3
Leg fat-free mass (left)	2.6	13.7	35.8	-1.1	-0.7	3.5	6.0	5.7	0.8
Trunk fat percentage	0.9	3.6	7.1	-0.8	-0.6	2.3	2.7	2.6	1.1
Hand grip strength (right)	1.1	3.0	7.0	-2.6	-0.0	0.2	2.2	2.2	1.1
Townsend deprivation index at recruitment	1.8	2.5	5.8	0.5	0.1	-1.6	-2.4	-2.1	-1.4
Current tobacco smoking	1.8	2.9	6.9	1.3	-1.1	-2.6	-2.0	-1.6	-1.0
Average weekly fortified wine intake	1.6	1.9	4.8	0.6	-0.8	-2.2	-1.7	-1.6	-0.6
Maternal smoking around birth	0.4	0.6	2.2	1.5	-0.4	-0.6	0.3	-0.1	0.8
Fed-up feelings	0.2	0.4	1.3	0.8	1.1	0.1	0.3	0.2	0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	2.6	1.6	-0.1	0.5	-0.6	-0.7	-0.7
Relative age voice broke	1.5	2.3	12.4	-3.5	0.7	0.8	-0.3	-0.3	-0.1
Taking other prescription medications	0.2	0.2	0.8	-0.2	-0.7	-0.2	0.1	-0.3	-0.9
Age when periods started (menarche)	0.1	0.1	0.5	-0.3	-0.4	0.7	0.3	0.1	-0.0
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	3.2	0.2	1.8	0.1	1.2	0.7	0.4
Heel bone mineral density (BMD) T-score, automated (left)	1.0	2.3	5.9	-0.4	-0.3	1.0	2.4	2.4	0.8
Tinnitus: Yes, but not now, but have in the past	0.6	0.7	3.1	0.1	1.8	0.0	-0.7	-0.3	0.7
Qualifications: CSEs or equivalent	0.9	1.2	3.6	0.7	1.1	1.9	1.3	0.5	0.0
Serious illness, injury or assault to yourself	0.6	0.7	2.8	-1.7	1.0	-0.5	-0.3	-0.2	0.6
High blood pressure	1.8	4.9	9.1	-0.5	3.0	-0.9	2.4	2.6	2.6
Hayfever, allergic rhinitis or eczema	0.2	0.4	0.9	-0.4	0.9	-0.3	1.0	0.6	0.4
Multivitamins +/- minerals	0.5	0.6	1.9	-1.0	1.4	-0.5	0.0	0.2	-0.7
Stomach or abdominal pain in last month	1.0	1.3	2.3	0.9	1.2	1.0	-0.9	-1.5	1.0
Supplements: Glucosamine	0.5	0.7	2.8	-1.7	0.3	-0.7	-0.7	-0.4	-0.3
Diverticular disease/diverticulitis (self-reported)	1.3	1.6	6.1	-0.3	-1.6	2.5	-0.1	-0.5	-0.6
Medication: Atenolol	1.0	1.3	4.7	-0.9	-0.2	0.2	1.3	2.2	0.4
Medication: Levothyroxine sodium	0.7	1.2	4.3	0.3	-0.0	-0.5	1.6	2.1	-0.3
Sitting height	1.3	9.5	20.2	1.0	-3.3	1.7	4.5	4.5	-1.3
Chronic bronchitis/emphysema (father)	0.1	0.1	0.3	-0.1	0.6	0.2	-0.3	-0.2	-0.0
High blood pressure (mother)	1.2	1.7	4.3	0.6	2.1	0.6	1.6	1.0	1.3
Body mass index (BMI)	0.7	3.0	5.6	-1.6	0.3	2.4	2.3	2.0	0.5
Impedance of leg (left)	0.4	2.1	5.6	2.4	-1.6	0.2	-1.3	-1.6	-0.6
Leg predicted mass (left)	2.6	13.7	35.8	-1.0	-0.7	3.5	6.0	5.7	0.8
Trunk fat mass	1.8	7.6	17.0	-0.9	-0.9	3.3	4.1	3.9	1.0
Waist circumference	0.7	2.5	7.2	-1.0	-0.0	2.7	2.0	1.4	-0.9
Number of incorrect matches in round	0.6	0.9	3.4	-0.7	-0.1	0.2	1.9	1.3	-0.2
Past tobacco smoking	0.3	0.6	2.5	0.4	0.1	1.6	0.1	-0.4	0.8
Alcohol usually taken with meals	0.7	1.1	6.1	-2.5	0.0	-0.5	-0.3	0.3	-0.6
Nervous feelings	0.6	1.2	2.8	1.7	-0.3	-1.7	-0.4	0.4	1.1
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	1.9	0.9	1.4	-0.4	-1.1	-0.9	-0.5
Hearing difficulty/problems with background noise	1.3	2.0	5.7	-0.9	0.8	1.2	2.4	1.7	0.9
Hair/balding pattern: Pattern 2	0.6	0.7	2.6	1.6	0.3	-0.0	-0.4	-1.1	-0.3
Had menopause	0.4	0.5	1.0	-0.4	-0.8	0.5	1.0	1.0	0.2
Had other major operations	0.5	0.7	1.8	-1.3	-0.1	-0.2	1.1	0.8	0.6
Forced vital capacity (FVC)	0.9	3.5	7.7	1.3	-0.7	2.1	2.8	2.5	-0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.3	2.7	-1.4	-0.9	0.5	1.6	1.6	-0.1
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.5	0.7	0.7	-0.1	0.4	-0.1	-0.4
Qualifications: None of the above	0.2	0.4	1.5	0.3	0.1	0.3	-0.7	-0.7	-1.2
Financial difficulties in last 2 years	0.9	1.2	4.9	-0.7	-0.9	-0.8	0.4	0.1	-2.2
Mouth/teeth dental problems	3.1	4.7	10.2	-0.9	0.1	-2.8	-3.2	-2.8	-1.5
Heart attack	0.5	0.6	2.3	-0.4	0.9	1.5	0.1	-0.4	-0.4
Allergy	0.3	0.7	1.5	0.1	-1.2	0.4	-1.2	-0.9	-0.7
Pain all over the body in last month	1.2	1.3	3.9	2.0	1.1	1.3	-0.4	-0.7	0.4
Diabetes (self-reported)	0.2	0.4	1.6	-0.3	-0.5	0.5	0.1	-0.1	-1.2
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	2.0	0.1	1.4	-0.6	-0.6	-0.7	0.1
Medication: Ramipril	0.3	0.4	1.5	1.2	0.5	0.6	0.3	-0.1	-0.1
Medication: Simvastatin	0.9	1.4	4.2	-2.0	0.8	-1.3	-0.6	-0.2	-1.2
Fluid intelligence score	0.7	1.4	3.6	1.0	1.8	0.1	0.4	0.4	1.9
Illnesses of siblings	0.3	0.5	2.0	0.2	-1.4	-0.7	-0.2	0.5	0.0
Neuroticism score	0.3	0.5	1.5	1.2	0.1	-0.9	0.3	0.8	0.4
Weight	2.7	13.2	31.8	-1.2	-1.2	3.9	5.6	5.4	0.4
Impedance of arm (right)	0.3	1.2	3.6	1.2	-1.2	-1.9	-0.8	-0.4	-0.2
Arm fat percentage (right)	0.5	1.9	3.9	-1.2	-0.1	1.5	2.0	1.9	0.7
Trunk fat-free mass	2.7	15.2	39.4	0.0	-1.7	3.8	6.3	5.9	-0.0
Hip circumference	2.5	10.8	27.1	-1.6	-0.6	3.1	5.2	5.0	0.7
Time employed in main current job	0.8	0.9	2.9	0.4	-0.4	0.2	1.4	0.7	1.7
Alcohol intake versus 10 years previously	1.5	2.3	5.9	2.4	-0.6	1.9	-0.9	-1.6	-0.8
Father’s age at death	0.5	0.7	1.9	-0.9	0.2	0.2	-1.0	-1.4	-0.6
Worrier / anxious feelings	0.8	1.4	4.1	0.0	-0.4	-0.6	2.0	2.0	0.2
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.2	2.4	0.1	1.3	0.1	-1.6	-1.6	-0.7
Falls in the last year	5.7	7.7	15.3	1.2	1.1	1.5	3.8	3.5	3.9
Hair/balding pattern: Pattern 3	0.2	0.3	1.2	0.3	1.1	0.0	-0.4	-0.2	-0.2
Number of live births	0.3	0.4	0.8	-0.5	-0.1	-0.4	0.7	0.9	0.7
Forced expiratory volume in 1-second (FEV1)	0.9	2.9	7.5	-0.1	-0.2	2.7	2.3	2.0	-0.6
Pulse rate	1.0	1.7	4.5	0.3	-0.5	0.7	2.1	2.0	-0.8
Happiness	1.1	1.3	2.1	1.3	0.7	-1.4	-1.2	-0.8	1.3
Noisy workplace	0.8	1.0	2.0	-1.3	0.0	1.4	1.0	0.0	-1.1
Qualifications: A levels/AS levels or equivalent	1.5	3.3	6.1	-0.2	2.1	2.5	1.9	1.8	1.6
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.1	2.8	-0.3	0.8	1.2	0.9	1.0	1.7
Mouth/teeth dental problems: Dentures	0.4	0.7	1.6	0.2	-1.0	-0.0	1.2	1.1	-0.4
Asthma	0.8	1.6	4.1	1.5	1.0	0.1	2.0	1.2	0.9
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.7	2.0	-1.1	1.4	0.7	-0.1	-0.7	-0.4
Medication: Cholesterol lowering	0.4	0.7	2.6	-1.6	0.1	-1.1	-0.3	0.3	0.3
Depression (self-reported)	1.2	1.5	3.3	0.4	1.8	-1.8	-0.7	-1.4	-0.0
Medication: Lansoprazole	1.2	1.3	2.5	1.4	0.3	-0.6	-1.6	-1.4	-1.1
Prospective memory result	0.8	1.0	2.6	0.1	1.0	-0.9	-0.9	-0.9	1.6
Lung cancer (father)	0.2	0.3	1.1	-0.1	1.1	0.2	0.2	0.3	0.4
Illnesses of mother	2.1	2.6	8.3	-0.8	-2.9	-0.6	-1.3	-0.7	-1.9
Forced expiratory volume in 1-second (FEV1), Best measure	1.1	3.6	9.3	0.3	-0.7	3.1	2.6	2.1	-0.7
Pulse wave Arterial Stiffness index	0.4	0.5	1.8	0.2	0.0	1.4	0.7	0.3	-0.7
Impedance of arm (left)	0.2	1.1	2.8	1.4	-0.8	-1.7	-0.9	-0.5	0.5
Arm fat mass (right)	1.3	5.3	13.0	-0.9	-0.6	2.7	3.6	3.2	0.6
Trunk predicted mass	2.7	15.4	39.9	0.2	-1.7	3.8	6.3	5.9	0.1
Standing height	2.5	24.7	60.4	1.2	-3.6	3.8	7.8	7.7	-0.1
Length of working week for main job	0.2	0.2	0.6	0.3	0.4	0.6	0.4	-0.1	0.7
Exposure to tobacco smoke at home	0.9	1.0	2.0	-1.4	-0.4	1.1	0.9	1.2	0.0
Breastfed as a baby	2.1	2.6	6.1	-0.9	0.4	0.8	2.0	2.5	2.0
Tense / ‘highly strung’	0.4	0.6	3.4	0.0	-0.0	-1.8	-0.3	0.5	0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.8	2.7	-1.4	-0.1	-0.2	-0.1	0.5	-1.6
Hair/balding pattern: Pattern 4	0.2	0.6	0.9	-0.8	-0.9	0.5	0.5	0.9	-0.8
Birth weight of first child	0.8	1.5	7.7	-2.8	0.5	-0.9	0.1	-0.0	-0.2
Peak expiratory flow (PEF)	1.9	4.5	13.1	-1.5	0.0	3.6	2.6	2.2	0.2
Pulse wave reflection index	1.1	1.3	4.0	0.8	2.0	0.1	-0.6	-1.4	1.0
Ever highly irritable/argumentative for 2 days	1.5	1.8	4.0	-1.3	2.0	-0.2	1.2	1.3	1.4
Loud music exposure frequency	3.2	3.4	17.9	-0.4	-0.2	4.2	1.5	0.3	0.6
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.6	-0.8	-0.1	0.8	0.4	0.4	0.6
Mouth/teeth dental problems: Bleeding gums	3.5	4.6	8.6	-0.3	-0.4	2.9	2.9	2.9	1.3
Blood clot in the leg (DVT)	1.3	1.7	5.6	-0.0	2.1	-0.6	-0.1	0.0	2.4
Medication: Paracetamol	0.4	0.6	2.6	-1.6	0.9	0.5	0.3	-0.1	0.2
Headache pain in last month	0.7	1.3	2.9	-1.3	-0.4	1.1	1.0	1.7	-0.9
Medication for cholesterol, blood pressure or diabetes	0.7	1.2	4.0	1.4	-0.6	2.0	0.2	-0.9	-0.4
Glaucoma (self-reported)	2.1	2.5	5.9	-1.5	-2.4	0.0	1.0	1.2	-2.1
Gout (self-reported)	0.4	0.6	1.4	0.1	-0.5	0.1	-1.2	-1.1	-0.7
Hypothyroidism/myxoedema (self-reported)	0.4	0.7	1.8	0.0	-0.4	-0.6	1.3	1.3	-0.6
Medication: Amlodipine	1.2	1.7	5.0	0.7	2.2	-1.7	0.9	0.9	0.1
Medication: Ventolin 100micrograms inhaler	0.6	0.8	2.0	1.4	-1.0	0.1	0.3	-0.2	-1.2
Birth weight	0.2	0.4	1.0	-0.8	-0.0	-0.9	-1.0	-0.4	0.3
Chronic bronchitis/emphysema (mother)	0.9	1.0	3.8	-0.0	1.4	0.6	-0.0	-0.3	1.9
High blood pressure (siblings)	0.5	0.7	1.6	-1.0	0.9	1.2	0.8	-0.0	-0.4
Forced vital capacity (FVC), Best measure	1.4	5.2	11.6	0.9	-1.5	2.5	3.4	3.0	-1.1
Body fat percentage	0.8	3.3	6.0	-0.9	-0.6	2.4	2.5	2.4	0.9
Leg fat percentage (right)	0.7	2.5	7.6	-1.1	-0.3	2.8	1.9	1.6	0.6
Arm fat-free mass (right)	2.8	14.3	35.1	-0.6	-1.5	4.4	5.9	5.4	0.3
Exposure to tobacco smoke outside home	0.3	0.4	2.2	0.2	1.5	0.3	-0.4	-0.3	-0.0
Comparative body size at age 10	1.6	4.4	11.1	1.3	1.3	-1.1	-3.3	-3.1	1.1
Number of full brothers	1.2	1.5	4.5	0.5	2.1	-0.3	0.3	0.2	2.0
Worry too long after embarrassment	0.3	0.4	0.8	-0.9	-0.5	-0.9	-0.7	-0.2	-0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.9	0.2	0.7	0.2	-0.2	0.2	-0.9
Wheeze or whistling in the chest in last year	0.3	0.5	1.2	0.8	-0.5	0.9	1.1	0.4	-0.3
Number of children fathered	2.4	2.7	8.3	-0.2	-2.9	-0.8	-0.2	0.1	-2.7
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	1.1	0.9	-0.2	0.3	-0.0	0.1	1.0
Age at first live birth	0.5	0.8	2.0	-1.4	-1.1	1.1	-0.4	-0.4	-0.3
Pulse wave peak to peak time	0.4	0.4	1.2	0.2	-0.2	-1.0	-0.0	0.4	1.1
Health satisfaction	0.9	1.2	3.7	-1.9	0.6	-1.4	-1.0	-0.3	0.1
Shortness of breath walking on level ground	0.8	0.9	3.8	-2.0	0.9	-0.7	-0.1	-0.2	-0.6
Qualifications: College or University degree	0.7	2.4	11.2	0.5	0.3	-0.6	1.0	1.2	3.3
Eye problems/disorders: None of the above	0.7	0.8	2.0	1.0	1.4	0.9	-0.5	-0.7	0.2
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.9	-0.3	0.9	0.2	0.4	0.3	0.4
Emphysema/chronic bronchitis	2.8	3.1	9.6	-1.3	-1.5	-3.1	-1.8	-0.8	-1.1
Medication for pain relief, constipation, heartburn	0.4	0.8	1.3	1.1	-1.1	-0.8	-1.0	-0.5	0.0
Neck or shoulder pain in last month	0.1	0.2	0.4	0.4	0.3	0.2	-0.6	-0.4	0.3
Medication: Blood pressure	1.0	1.8	5.1	0.4	1.4	-0.6	1.4	2.3	1.0
Angina (self-reported)	0.4	0.5	1.2	-1.1	0.3	-0.4	0.8	0.4	-0.9
Migraine (self-reported)	0.1	0.1	0.6	0.8	0.0	0.2	0.3	-0.0	0.1
Medication: Ibuprofen	0.6	0.7	2.6	-0.6	1.6	0.6	0.0	-0.9	-0.1
Medication: Allopurinol	0.4	0.5	0.8	-0.6	-0.9	-0.8	-0.9	-0.6	-0.3
Medication: Omeprazole	0.4	0.4	2.2	-0.1	1.5	0.1	0.3	0.3	-0.5
Medication: Seretide 50 evohaler	0.7	0.8	2.4	0.5	-0.2	-0.6	1.2	1.5	0.7
Mean time to correctly identify matches	0.2	0.4	1.3	0.2	0.9	-1.1	0.0	0.1	-0.2
Heart disease (mother)	1.6	2.0	6.0	0.5	0.5	0.1	2.5	2.2	0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.2	2.7	4.9	0.2	2.2	-0.8	-1.9	-2.2	1.5
Whole body fat mass	1.7	7.2	15.9	-1.1	-1.0	3.2	4.0	3.7	0.8
Leg fat mass (right)	1.8	6.8	14.1	-1.3	-0.8	3.5	3.7	3.4	0.6
Arm predicted mass (right)	2.6	13.4	31.9	-0.4	-1.6	4.4	5.6	5.1	0.4
Pulse rate, automated reading	1.4	4.7	11.2	-1.3	-1.8	1.1	3.1	3.3	-0.9
Alcohol intake frequency.	0.8	1.9	6.8	0.3	1.5	2.6	0.4	0.1	1.5
Comparative height size at age 10	2.1	11.3	25.8	2.1	-1.9	2.2	5.1	5.1	2.0
Number of full sisters	1.9	2.3	4.5	-1.0	1.5	-1.5	-1.9	-2.1	0.3
Suffer from ‘nerves’	0.4	0.7	1.9	1.4	0.6	-0.6	-0.8	-0.8	0.3
Overall health rating	0.4	0.8	2.9	0.8	1.7	-0.7	-0.7	-0.7	-0.5
Chest pain or discomfort	1.5	2.2	5.4	0.7	2.3	-0.7	1.4	1.2	1.9
Had major operations	1.1	1.3	2.7	-0.7	0.4	-1.3	-1.6	-1.5	0.4
Age at last live birth	0.7	1.0	2.1	-1.3	-1.5	-0.8	-0.8	-0.2	-1.0
Family relationship satisfaction	0.5	0.6	1.0	-0.6	0.9	-0.6	-0.8	-0.4	1.0
Leg pain on walking	1.4	1.7	3.4	-0.7	1.8	-1.6	-1.3	-1.4	0.2
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.8	2.5	-0.9	-1.0	0.1	0.1	-0.4	-1.6
Commuting to job workplace: Car/motor vehicle	0.8	0.9	1.6	-1.2	0.7	0.9	0.9	1.3	0.2
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	0.9	0.9	-0.0	0.7	-0.6	-0.8	0.8
Medication: Aspirin	0.5	0.6	1.1	-1.0	0.4	-0.9	0.8	1.0	0.2
Supplements: Vitamin C	0.5	0.6	2.0	1.4	0.3	-0.5	-0.3	-0.4	1.1
Knee pain experienced in last month	0.9	1.4	3.0	-1.5	-1.0	0.9	0.9	0.9	-1.7
Hypertension (Self-reported)	1.6	4.6	7.7	-0.5	2.5	-0.9	2.6	2.8	2.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.4	0.1	-0.2	-1.1	-0.9	-0.5	-1.2
Illnesses of father: Heart disease	0.9	1.3	2.8	-0.9	-0.6	-1.7	0.4	1.4	-1.2
Illnesses of siblings: Diabetes	0.8	0.9	3.1	-1.2	0.1	-0.5	-0.8	-0.4	-1.8
Smoking status: Previous	0.4	0.6	1.4	-0.9	-0.0	-0.8	0.7	1.2	-0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.2	2.3	1.1	0.1	0.9	1.5	1.4	-0.9
Whole body fat-free mass	2.8	16.1	41.3	-0.4	-1.6	4.0	6.4	6.0	0.3
Leg fat-free mass (right)	2.7	14.4	36.8	-1.1	-1.0	3.7	6.1	5.8	0.6
Arm fat percentage (left)	0.6	2.3	3.8	-1.3	0.0	1.9	2.0	1.9	1.0
Average weekly red wine intake	0.5	0.7	2.2	-0.1	0.2	-0.5	0.9	1.0	1.5
Handedness (chirality/laterality): Left-handed	0.4	0.5	0.7	-0.7	0.6	-0.8	-0.8	-0.7	0.3
Mood swings	0.8	1.4	3.5	1.9	1.4	-1.4	0.8	0.5	-0.5
Loneliness, isolation	1.1	1.5	5.6	-0.1	-0.1	-1.1	-2.4	-1.5	0.3
Long-standing illness, disability or infirmity	0.3	0.4	1.0	-0.5	-0.1	0.3	-0.9	-0.8	-1.0
Ever had bowel cancer screening	0.5	0.6	2.8	-0.5	1.7	0.0	-0.3	-0.7	0.1
Diabetes diagnosed by doctor	0.4	0.7	1.8	-1.4	-0.3	0.3	-0.3	-0.5	-1.3
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	0.9	0.6	1.0	-0.2	-0.2	-0.4	0.9
Friendships satisfaction	0.6	0.7	2.3	-1.5	-0.5	-0.6	-0.1	1.0	0.7
Qualifications: nursing, teaching	0.7	1.1	3.1	1.4	-0.9	1.8	0.3	0.3	-0.7
Commuting to job workplace: Walk	1.3	1.4	4.2	1.5	0.2	-2.1	-0.7	-1.1	-0.3
Eye problems/disorders: Cataract	1.3	1.5	3.5	0.2	-0.5	-1.9	1.4	1.6	1.0
Mouth/teeth dental problems: Mouth ulcers	1.5	2.3	4.0	1.0	1.3	2.0	1.8	1.1	1.7
Medication for cholesterol	2.0	3.0	6.3	-1.3	-1.9	-1.4	-2.5	-1.7	-1.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.9	2.7	1.6	0.3	0.3	-0.8	-1.2	0.5
Back pain experienced in last month	0.2	0.2	0.8	-0.4	0.2	0.1	0.9	0.6	0.0
Mineral and other dietary supplements	0.4	0.5	1.0	0.9	-0.7	0.4	1.0	0.7	-0.1
Breast cancer (self-reported)	1.5	1.8	3.5	-1.4	-1.2	0.7	1.7	1.9	-0.6
Asthma (self-reported)	0.9	1.9	5.5	1.3	1.1	0.2	2.3	1.5	0.7
Osteoporosis (self-reported)	2.4	3.0	8.4	0.0	0.2	1.4	2.9	2.8	0.2
Osteoarthritis (self-reported)	1.4	1.9	4.0	-0.6	-0.7	-1.3	-1.6	-1.5	-2.0
Medication: Aspirin	0.4	0.5	1.2	-1.1	0.4	-0.7	0.5	0.8	0.0
Medication: Gliclazide	0.4	0.5	1.8	-0.1	0.6	-0.2	-0.5	-0.7	-1.3
Illnesses of father: None of the above (group 1)	2.2	2.7	6.5	2.5	2.3	-0.0	-0.9	-1.4	1.2
Smoking status: Current	2.6	4.1	8.8	1.3	-0.8	-3.0	-2.5	-2.3	-1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	1.9	3.8	-1.9	-1.2	1.9	0.3	0.4	-1.4
Whole body water mass	2.7	15.5	40.2	-0.4	-1.4	3.9	6.3	5.9	0.3
Leg predicted mass (right)	2.6	13.9	35.8	-1.1	-0.9	3.6	6.0	5.7	0.5
Arm fat mass (left)	1.3	5.3	12.2	-1.0	-0.4	2.8	3.5	3.1	1.0
Number of self-reported non-cancer illnesses	0.7	1.2	5.6	-0.6	2.4	-0.9	0.4	0.2	0.3
Average weekly champagne plus white wine intake	1.0	1.4	4.0	-2.0	-1.6	-0.9	0.6	0.7	-0.6
Miserableness	0.2	0.4	0.8	-0.2	0.0	0.9	0.5	0.7	0.8
Guilty feelings	0.9	1.4	3.7	0.5	0.6	-1.9	-1.3	-1.3	-0.6
Wears glasses or contact lenses	2.0	2.3	5.0	-2.2	-0.0	1.1	1.5	1.8	1.4
Ever taken oral contraceptive pill	1.1	1.2	2.4	-1.3	0.9	-0.0	1.0	1.5	1.2
Hearing aid user	1.7	1.9	4.5	-0.8	-2.1	0.6	1.7	1.3	-1.1
Mother’s age at death	1.4	1.8	3.6	-1.4	-0.4	-1.3	-1.9	-1.2	-1.4
Financial situation satisfaction	1.0	1.3	4.9	0.2	2.2	0.1	0.9	0.7	1.2
Tinnitus: Yes, now most or all of the time	0.7	0.8	2.0	-1.1	1.0	-1.4	-0.5	-0.4	-0.5
Commuting to job workplace: Public transport	0.6	0.7	2.6	0.8	-1.6	-0.4	-0.4	-0.1	-0.7
Eye problems/disorders: Glaucoma	3.0	3.6	10.6	-0.8	-3.3	-1.0	0.2	0.5	-3.0
Medication: Blood pressure	1.1	2.2	4.3	-0.3	2.0	-0.3	1.7	1.3	2.1
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.4	-0.6	-0.0	-0.3	0.4	0.3	-0.1
Supplements: Fish oil (including cod liver oil)	0.3	0.4	1.9	-1.4	0.1	-0.3	-0.3	0.2	0.4
High cholesterol (Self-reported)	0.4	0.6	3.0	-1.7	0.8	0.3	-0.1	0.0	0.2
Medication: Bendroflumethiazide	0.7	1.0	2.7	0.6	0.4	0.5	1.6	1.6	0.2
Medication: Paracetamol	0.3	0.5	1.2	-1.1	0.6	1.0	0.3	-0.4	0.2
Medication: Lisinopril	1.3	1.7	3.9	1.4	2.0	-0.3	0.5	0.5	1.9
Medication: Atorvastatin	0.4	0.5	1.2	0.5	0.3	1.1	0.9	0.3	0.5
Illnesses of father: High blood pressure	1.1	1.4	3.5	-0.6	1.2	-1.5	0.8	0.6	1.9
Alcohol drinker status: Never	1.1	1.4	2.4	-0.1	1.4	0.3	1.3	1.6	1.4
Ever smoked	0.4	0.7	2.7	0.7	-0.3	-1.6	-0.4	-0.2	-0.8
Basal metabolic rate	2.9	15.8	40.6	-0.6	-1.5	4.1	6.4	5.9	0.3
Leg fat percentage (left)	1.0	3.6	9.9	-1.1	-0.4	3.1	2.4	2.1	0.4
Arm fat-free mass (left)	2.7	14.0	35.2	-0.4	-1.6	4.1	5.9	5.3	-0.0
Number of operations (self-reported)	0.9	1.4	2.0	-1.4	-1.1	-1.3	-1.1	-0.6	-1.4
Average weekly beer plus cider intake	0.5	0.7	1.8	-0.6	-0.7	0.0	-0.7	-0.9	-1.3
Irritability	0.9	1.5	6.5	2.5	0.6	-0.2	0.5	0.8	1.2
Risk taking	1.1	1.6	5.9	2.4	1.0	-0.4	-0.2	-0.6	1.4
Ever had prostate specific antigen (PSA) test	0.3	0.4	0.8	-0.1	-0.6	-0.9	-0.9	-0.1	0.6
Fractured/broken bones in last 5 years	1.5	2.0	4.4	-0.4	-0.6	2.0	2.1	1.6	0.6
Age started oral contraceptive pill	2.1	2.7	6.3	1.7	0.4	0.6	2.5	2.0	1.5
Diastolic blood pressure, automated reading	1.0	3.2	9.1	-2.1	0.5	-0.2	2.1	3.0	0.9
Ever depressed for a whole week	1.2	1.5	4.2	-1.2	0.5	-2.1	-0.5	-0.1	-1.6
Unable to work because of sickness or disability	1.0	1.2	2.3	1.0	1.3	-0.6	-1.4	-1.5	-0.0
Commuting to job workplace: Cycle	2.0	2.4	5.6	-0.2	-1.2	1.4	2.4	2.1	0.7
Myopia	1.4	2.0	5.8	0.7	1.1	-0.0	-2.2	-2.4	-0.0
Vascular/heart problems diagnosed by doctor	1.6	4.3	6.8	0.5	-2.6	0.5	-2.4	-2.4	-2.6
Cholesterol lowering medication	0.4	0.6	2.6	-0.5	1.6	0.2	0.7	-0.2	-0.1
Medication: Omeprazole (e.g. Zanprol)	0.4	0.4	2.1	0.0	1.4	0.4	0.2	0.3	-0.5
Pain experienced in last month	0.2	0.3	0.8	0.9	-0.1	-0.7	0.5	0.1	0.7
Supplements: Calcium	0.3	0.4	0.7	-0.8	0.4	-0.9	-0.7	-0.0	-0.3
Basal cell carcinoma (self-reported)	0.9	1.0	1.7	-1.2	0.5	-1.1	0.9	1.3	0.9
Heart attack/myocardial infarction (self-reported)	0.5	0.6	1.9	-0.1	1.0	1.4	-0.0	-0.6	-0.3
Deep venous thrombosis (DVT) (self-reported)	1.1	1.5	5.4	-0.1	1.8	-0.4	-0.0	0.2	2.3
Heart disease (siblings)	1.0	1.3	2.2	-1.5	0.5	-0.8	-1.4	-0.9	-1.3
Alcohol drinker status: Previous	1.1	1.2	4.8	2.2	0.1	-1.2	-0.3	-0.6	0.9
Pack years of smoking	0.1	0.2	0.5	0.0	-0.6	0.7	-0.4	-0.4	0.3
Impedance of whole body	0.4	1.8	3.7	1.9	-1.3	-1.2	-1.5	-1.3	-0.2
Leg fat mass (left)	2.1	8.1	16.6	-1.4	-0.8	3.8	4.1	3.8	0.6
Arm predicted mass (left)	2.8	14.1	35.5	-0.2	-1.7	4.2	6.0	5.4	-0.0