Hub : Genes

MTERFD3

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0560 0.0240 0.00320 0.032 0.019 0.015 0.024 0.019 7.3e-05 0.0018 0.0053 0.00061 2.2e-03
2 GTEx Spleen 0.3570 0.1120 0.00610 0.019 NA 0.024 NA 0.083 1.1e-01 NA 0.0790 NA 3.7e-03
3 GTEx Stomach 0.1840 0.0800 0.00240 0.132 NA 0.047 NA 0.099 7.1e-07 NA 0.0028 NA 1.9e-05
4 TCGA Breast Invasive Carcinoma 0.0210 0.0107 0.00081 0.014 0.011 0.006 NA 0.012 6.7e-04 0.0024 0.0170 NA 1.3e-03
5 TCGA Colon Adenocarcinoma 0.0840 0.0480 0.00420 0.063 0.044 0.030 NA 0.050 1.6e-04 0.0015 0.0072 NA 7.1e-04
6 TCGA Kidney Renal Clear Cell Carcinoma 0.0779 0.0358 0.00200 -0.002 0.022 0.017 NA 0.002 5.9e-01 0.0015 0.0043 NA 2.0e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 0.3 0.4 1.3 -0.0 0.7 -1.2 -0.7 -0.4 -0.3
Bipolar Disorder or Schizophrenia 0.6 1.4 4.6 1.0 0.4 -2.2 -1.0 -1.0 -0.9
Depressed Affect (Nagel 2018) 0.5 1.1 2.2 0.8 0.6 0.5 1.4 1.5 1.2
Depression (Nagel 2018) 0.3 0.5 2.5 1.6 -0.0 0.6 0.2 -0.1 0.1
Intelligence (Savage-Jansen 2018) 0.4 1.4 2.9 -0.3 0.3 1.2 1.7 1.7 1.0
Neuroticism (Nagel 2018) 0.2 0.6 1.0 1.0 0.5 -1.0 0.5 0.7 0.6
Schizophrenia (2018) 0.5 1.1 3.3 1.4 0.0 -1.8 -0.8 -0.9 -0.3
Schizophrenia vs Biploar Disorder 0.6 0.7 2.4 -0.5 -0.9 -1.5 -0.9 -0.2 0.0
Worry (Nagel 2018) 0.2 0.4 0.7 0.9 -0.4 -0.7 0.6 0.6 0.4
Alzheimer’s Disease (in mother) 2.7 3.1 10.6 -0.0 0.9 -0.0 -2.6 -3.2 -0.7
Alzheimer’s Disease (in father) 1.6 1.7 8.3 -0.8 -2.9 0.8 0.1 0.4 -0.9
Alzheimer’s Disease (including proxy) 2.1 3.1 8.8 -0.1 -0.6 0.2 -2.9 -3.0 -0.8
Crohns Disease (2017) 0.7 1.6 5.2 -0.0 0.1 0.7 2.3 1.9 0.5
Irritable Bowel Disease (IBD) 0.4 0.8 2.6 0.4 0.2 -0.4 1.4 1.6 0.1
Ulcerative Colitis (UC) 0.2 0.3 0.8 0.7 -0.4 -0.9 -0.1 0.1 -0.6
Major Depression (MDD) 0.9 1.0 1.9 1.4 -0.8 -0.7 1.4 1.0 -0.3
Reaction Time 0.4 0.8 2.3 0.9 1.5 -1.2 0.0 0.2 0.4
Verbal and Numeric Reasoning (VNR) 0.6 1.4 3.5 -0.0 1.7 0.5 1.0 0.7 1.9
Breast Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Ovarian Cancer 0.7 0.9 2.4 1.6 -0.2 -0.1 -0.3 -0.7 -1.6
Prostate Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Age at First Birth 0.6 0.9 2.7 -0.6 1.6 0.0 -0.8 -0.5 1.1
Bipolar Disorder (2011) 1.1 1.1 2.1 -0.0 -0.1 -1.4 -1.2 -1.4 -1.1
Body Mass Index (BMI) (2010) 1.4 2.0 5.1 0.1 -1.1 1.1 2.0 2.2 -0.4
Coronary Artery Disease (CAD) 1.5 1.8 4.7 -1.6 -2.2 0.2 -0.0 0.3 -1.8
Crohns Disease (2012) 0.5 0.8 1.8 0.5 -0.4 -0.5 1.3 0.9 -1.3
Mean Putamen Volume 1.4 1.6 4.6 0.9 -0.2 1.5 2.1 1.1 0.8
Fasting Glucose 0.6 0.8 2.1 0.3 -1.4 0.4 0.4 0.3 -1.4
HbA1C 0.8 0.9 1.6 -0.4 -0.2 0.6 -1.2 -1.2 -1.2
HDL Cholesterol 1.3 2.2 4.3 -0.7 -1.6 -0.1 2.1 1.8 -1.5
LDL Cholesterol 0.9 1.4 4.2 0.5 -2.1 -1.8 0.2 0.7 -0.7
Lupus 0.8 1.2 5.1 0.1 -2.2 1.1 0.1 0.5 -0.6
Neuroticism (2016) 1.0 1.4 3.6 1.5 -1.9 -1.6 -0.0 0.2 -0.2
Primary Biliary Cirrhosis 0.2 0.3 0.8 -0.8 0.3 0.0 -0.9 -0.1 -0.7
Rheumatoid Arthritis 0.5 0.7 1.3 -1.0 0.2 -1.1 -1.1 -0.4 -0.7
Schizophrenia (2014) 0.5 1.0 3.6 1.5 0.1 -1.9 -0.2 -0.4 0.0
Triglycerides 1.6 2.6 4.9 -1.7 0.4 -2.0 -2.2 -1.5 -1.1
Type 2 Diabetes (T2D) (2012) 1.6 1.8 3.6 0.3 -1.3 1.9 1.3 0.8 -1.8
Ulcerative Colitis 0.3 0.5 1.1 0.3 -1.0 -0.6 0.4 1.0 -0.2
Blood Eosinophil Count 0.1 0.5 1.3 -0.1 -0.8 1.1 1.0 0.3 0.4
Blood Platelet Count 0.2 2.2 5.9 0.8 0.8 0.3 -1.4 -2.4 1.9
Blood Red Count 0.3 3.3 5.6 1.5 2.4 1.8 -1.9 -2.3 0.4
Blood White Count 0.4 2.6 8.5 -0.2 0.4 1.0 -2.4 -2.9 -0.2
Heel T-Score 1.0 8.1 22.8 -1.0 1.2 3.1 4.8 3.6 1.0
BMI 1.0 5.9 11.6 -1.8 -0.6 3.2 3.4 3.1 -0.1
Height 2.6 50.3 126.1 2.4 -4.2 5.5 11.2 11.0 1.3
Waist Hip Ratio (WHR) 1.9 8.7 22.0 2.5 1.0 -0.4 -3.7 -4.7 -3.0
Systolic Blood Pressure 0.4 2.1 3.4 -1.5 1.6 -1.4 1.3 1.9 0.9
Smoking Status 1.2 2.8 9.4 1.2 -0.4 -3.1 -1.8 -1.4 -0.6
Allergy or Eczema 0.2 0.7 1.6 -0.3 0.7 -0.3 1.3 1.1 0.7
Cardiovascular Disease 1.1 3.5 7.2 -0.9 2.7 -0.5 1.9 2.0 2.3
Hypothyroidism (self reported) 0.2 0.5 2.1 -0.2 -1.4 0.1 0.3 0.3 -0.8
Respiratory disease 0.7 1.4 4.2 1.3 0.5 -0.8 2.1 1.3 0.6
Type 2 Diabetes (T2D) (2018) 0.7 1.3 4.4 -0.2 -1.3 1.0 -0.3 -0.6 -2.1
Lung FEV1/FVC ratio 0.5 2.4 9.9 -3.1 1.1 -0.3 -1.7 -0.5 -0.2
Lung FVC 0.2 1.0 5.2 -0.4 -0.4 0.0 0.4 0.4 -2.3
Neuroticism 0.3 0.6 1.5 1.2 -0.5 -0.8 0.4 1.0 0.6
Chronotype (morning person) 2.3 5.3 27.5 -5.2 0.7 -1.2 0.4 1.5 -0.1
Hair Pigment 0.1 1.5 2.7 -1.6 0.9 -1.3 -1.1 -1.5 -0.6
Tanning 0.3 3.1 6.0 -0.2 -2.5 1.4 2.1 2.2 -1.1
Hand grip strength (left) 1.0 2.7 8.2 -2.9 -1.0 -0.0 1.8 2.0 -0.0
Number of treatments/medications taken 0.1 0.3 0.5 -0.5 0.4 0.5 0.6 0.7 -0.3
Average weekly spirits intake 0.5 0.7 1.3 0.9 0.1 -1.1 -0.7 -0.6 1.1
Sensitivity / hurt feelings 0.6 1.0 3.3 -0.4 1.0 -1.8 -0.7 0.4 -0.9
Frequency of depressed mood in last 2 weeks 0.4 0.6 2.0 1.4 0.8 0.3 -0.5 -0.7 0.1
Hearing difficulty/problems: Yes 0.8 1.2 3.6 -0.8 0.1 1.2 1.9 1.3 0.4
Relative age of first facial hair 1.0 2.1 8.5 -2.9 -0.0 -0.8 -1.4 -1.1 0.1
Other serious medical condition/disability diagnosed by doctor 0.1 0.2 0.4 0.6 -0.6 -0.3 -0.2 -0.1 0.2
Ever used hormone-replacement therapy (HRT) 0.7 0.9 1.4 1.1 1.1 -1.1 0.9 0.1 -1.2
Ever had hysterectomy (womb removed) 0.7 0.8 1.8 0.5 -0.2 -1.0 1.4 1.2 -0.8
Systolic blood pressure, automated reading 1.0 2.9 8.9 -1.2 0.2 -0.9 2.3 3.0 1.1
Eye problems/disorders: Diabetes related eye disease 0.8 0.9 1.5 -0.9 1.2 -1.1 -1.1 -0.8 -0.2
Angina 0.4 0.6 1.4 -1.1 0.2 -0.3 0.8 0.3 -1.2
Medication for hormone replacement therapy 1.0 1.1 4.7 2.2 0.4 1.0 0.7 0.1 -0.7
Vitamin and mineral supplements 0.6 0.8 1.7 0.8 -1.0 1.3 1.0 0.6 0.3
Supplements: Zinc 1.2 1.3 4.7 2.2 1.3 -0.4 -0.5 -1.0 -0.3
Medication: Co-codamol 1.2 1.4 6.0 0.2 -0.5 -0.7 -0.7 -1.1 -2.4
Medication: Metformin 0.7 0.9 3.1 -0.9 -0.5 1.0 -0.2 -0.7 -1.8
Diabetes (father) 0.3 0.4 0.9 -0.5 0.1 0.9 -0.6 -1.0 0.3
Diabetes (mother) 0.5 0.6 1.6 -0.1 1.2 0.3 -0.5 -0.6 -1.3
Severe depression (siblings) 1.1 1.2 2.8 -1.7 0.7 0.9 0.9 1.0 1.1
Pack years adult smoking proportion 0.2 0.3 1.3 0.1 -0.6 1.2 -0.2 -0.4 0.5
Impedance of leg (right) 0.6 2.7 6.8 2.6 -1.2 -0.4 -1.9 -2.1 -0.3
Leg fat-free mass (left) 2.6 13.7 35.8 -1.1 -0.7 3.5 6.0 5.7 0.8
Trunk fat percentage 0.9 3.6 7.1 -0.8 -0.6 2.3 2.7 2.6 1.1
Hand grip strength (right) 1.1 3.0 7.0 -2.6 -0.0 0.2 2.2 2.2 1.1
Townsend deprivation index at recruitment 1.8 2.5 5.8 0.5 0.1 -1.6 -2.4 -2.1 -1.4
Current tobacco smoking 1.8 2.9 6.9 1.3 -1.1 -2.6 -2.0 -1.6 -1.0
Average weekly fortified wine intake 1.6 1.9 4.8 0.6 -0.8 -2.2 -1.7 -1.6 -0.6
Maternal smoking around birth 0.4 0.6 2.2 1.5 -0.4 -0.6 0.3 -0.1 0.8
Fed-up feelings 0.2 0.4 1.3 0.8 1.1 0.1 0.3 0.2 0.5
Frequency of unenthusiasm / disinterest in last 2 weeks 0.5 0.7 2.6 1.6 -0.1 0.5 -0.6 -0.7 -0.7
Relative age voice broke 1.5 2.3 12.4 -3.5 0.7 0.8 -0.3 -0.3 -0.1
Taking other prescription medications 0.2 0.2 0.8 -0.2 -0.7 -0.2 0.1 -0.3 -0.9
Age when periods started (menarche) 0.1 0.1 0.5 -0.3 -0.4 0.7 0.3 0.1 -0.0
Bilateral oophorectomy (both ovaries removed) 0.8 0.9 3.2 0.2 1.8 0.1 1.2 0.7 0.4
Heel bone mineral density (BMD) T-score, automated (left) 1.0 2.3 5.9 -0.4 -0.3 1.0 2.4 2.4 0.8
Tinnitus: Yes, but not now, but have in the past 0.6 0.7 3.1 0.1 1.8 0.0 -0.7 -0.3 0.7
Qualifications: CSEs or equivalent 0.9 1.2 3.6 0.7 1.1 1.9 1.3 0.5 0.0
Serious illness, injury or assault to yourself 0.6 0.7 2.8 -1.7 1.0 -0.5 -0.3 -0.2 0.6
High blood pressure 1.8 4.9 9.1 -0.5 3.0 -0.9 2.4 2.6 2.6
Hayfever, allergic rhinitis or eczema 0.2 0.4 0.9 -0.4 0.9 -0.3 1.0 0.6 0.4
Multivitamins +/- minerals 0.5 0.6 1.9 -1.0 1.4 -0.5 0.0 0.2 -0.7
Stomach or abdominal pain in last month 1.0 1.3 2.3 0.9 1.2 1.0 -0.9 -1.5 1.0
Supplements: Glucosamine 0.5 0.7 2.8 -1.7 0.3 -0.7 -0.7 -0.4 -0.3
Diverticular disease/diverticulitis (self-reported) 1.3 1.6 6.1 -0.3 -1.6 2.5 -0.1 -0.5 -0.6
Medication: Atenolol 1.0 1.3 4.7 -0.9 -0.2 0.2 1.3 2.2 0.4
Medication: Levothyroxine sodium 0.7 1.2 4.3 0.3 -0.0 -0.5 1.6 2.1 -0.3
Sitting height 1.3 9.5 20.2 1.0 -3.3 1.7 4.5 4.5 -1.3
Chronic bronchitis/emphysema (father) 0.1 0.1 0.3 -0.1 0.6 0.2 -0.3 -0.2 -0.0
High blood pressure (mother) 1.2 1.7 4.3 0.6 2.1 0.6 1.6 1.0 1.3
Body mass index (BMI) 0.7 3.0 5.6 -1.6 0.3 2.4 2.3 2.0 0.5
Impedance of leg (left) 0.4 2.1 5.6 2.4 -1.6 0.2 -1.3 -1.6 -0.6
Leg predicted mass (left) 2.6 13.7 35.8 -1.0 -0.7 3.5 6.0 5.7 0.8
Trunk fat mass 1.8 7.6 17.0 -0.9 -0.9 3.3 4.1 3.9 1.0
Waist circumference 0.7 2.5 7.2 -1.0 -0.0 2.7 2.0 1.4 -0.9
Number of incorrect matches in round 0.6 0.9 3.4 -0.7 -0.1 0.2 1.9 1.3 -0.2
Past tobacco smoking 0.3 0.6 2.5 0.4 0.1 1.6 0.1 -0.4 0.8
Alcohol usually taken with meals 0.7 1.1 6.1 -2.5 0.0 -0.5 -0.3 0.3 -0.6
Nervous feelings 0.6 1.2 2.8 1.7 -0.3 -1.7 -0.4 0.4 1.1
Frequency of tenseness / restlessness in last 2 weeks 0.6 0.9 1.9 0.9 1.4 -0.4 -1.1 -0.9 -0.5
Hearing difficulty/problems with background noise 1.3 2.0 5.7 -0.9 0.8 1.2 2.4 1.7 0.9
Hair/balding pattern: Pattern 2 0.6 0.7 2.6 1.6 0.3 -0.0 -0.4 -1.1 -0.3
Had menopause 0.4 0.5 1.0 -0.4 -0.8 0.5 1.0 1.0 0.2
Had other major operations 0.5 0.7 1.8 -1.3 -0.1 -0.2 1.1 0.8 0.6
Forced vital capacity (FVC) 0.9 3.5 7.7 1.3 -0.7 2.1 2.8 2.5 -0.6
Heel bone mineral density (BMD) T-score, automated (right) 0.6 1.3 2.7 -1.4 -0.9 0.5 1.6 1.6 -0.1
Ever unenthusiastic/disinterested for a whole week 0.2 0.2 0.5 0.7 0.7 -0.1 0.4 -0.1 -0.4
Qualifications: None of the above 0.2 0.4 1.5 0.3 0.1 0.3 -0.7 -0.7 -1.2
Financial difficulties in last 2 years 0.9 1.2 4.9 -0.7 -0.9 -0.8 0.4 0.1 -2.2
Mouth/teeth dental problems 3.1 4.7 10.2 -0.9 0.1 -2.8 -3.2 -2.8 -1.5
Heart attack 0.5 0.6 2.3 -0.4 0.9 1.5 0.1 -0.4 -0.4
Allergy 0.3 0.7 1.5 0.1 -1.2 0.4 -1.2 -0.9 -0.7
Pain all over the body in last month 1.2 1.3 3.9 2.0 1.1 1.3 -0.4 -0.7 0.4
Diabetes (self-reported) 0.2 0.4 1.6 -0.3 -0.5 0.5 0.1 -0.1 -1.2
Hayfever/allergic rhinitis (self-reported) 0.4 0.5 2.0 0.1 1.4 -0.6 -0.6 -0.7 0.1
Medication: Ramipril 0.3 0.4 1.5 1.2 0.5 0.6 0.3 -0.1 -0.1
Medication: Simvastatin 0.9 1.4 4.2 -2.0 0.8 -1.3 -0.6 -0.2 -1.2
Fluid intelligence score 0.7 1.4 3.6 1.0 1.8 0.1 0.4 0.4 1.9
Illnesses of siblings 0.3 0.5 2.0 0.2 -1.4 -0.7 -0.2 0.5 0.0
Neuroticism score 0.3 0.5 1.5 1.2 0.1 -0.9 0.3 0.8 0.4
Weight 2.7 13.2 31.8 -1.2 -1.2 3.9 5.6 5.4 0.4
Impedance of arm (right) 0.3 1.2 3.6 1.2 -1.2 -1.9 -0.8 -0.4 -0.2
Arm fat percentage (right) 0.5 1.9 3.9 -1.2 -0.1 1.5 2.0 1.9 0.7
Trunk fat-free mass 2.7 15.2 39.4 0.0 -1.7 3.8 6.3 5.9 -0.0
Hip circumference 2.5 10.8 27.1 -1.6 -0.6 3.1 5.2 5.0 0.7
Time employed in main current job 0.8 0.9 2.9 0.4 -0.4 0.2 1.4 0.7 1.7
Alcohol intake versus 10 years previously 1.5 2.3 5.9 2.4 -0.6 1.9 -0.9 -1.6 -0.8
Father’s age at death 0.5 0.7 1.9 -0.9 0.2 0.2 -1.0 -1.4 -0.6
Worrier / anxious feelings 0.8 1.4 4.1 0.0 -0.4 -0.6 2.0 2.0 0.2
Frequency of tiredness / lethargy in last 2 weeks 0.7 1.2 2.4 0.1 1.3 0.1 -1.6 -1.6 -0.7
Falls in the last year 5.7 7.7 15.3 1.2 1.1 1.5 3.8 3.5 3.9
Hair/balding pattern: Pattern 3 0.2 0.3 1.2 0.3 1.1 0.0 -0.4 -0.2 -0.2
Number of live births 0.3 0.4 0.8 -0.5 -0.1 -0.4 0.7 0.9 0.7
Forced expiratory volume in 1-second (FEV1) 0.9 2.9 7.5 -0.1 -0.2 2.7 2.3 2.0 -0.6
Pulse rate 1.0 1.7 4.5 0.3 -0.5 0.7 2.1 2.0 -0.8
Happiness 1.1 1.3 2.1 1.3 0.7 -1.4 -1.2 -0.8 1.3
Noisy workplace 0.8 1.0 2.0 -1.3 0.0 1.4 1.0 0.0 -1.1
Qualifications: A levels/AS levels or equivalent 1.5 3.3 6.1 -0.2 2.1 2.5 1.9 1.8 1.6
Serious illness, injury or assault of a close relative in last 2 years 1.0 1.1 2.8 -0.3 0.8 1.2 0.9 1.0 1.7
Mouth/teeth dental problems: Dentures 0.4 0.7 1.6 0.2 -1.0 -0.0 1.2 1.1 -0.4
Asthma 0.8 1.6 4.1 1.5 1.0 0.1 2.0 1.2 0.9
Medication: Ibuprofen (e.g. Nurofen) 0.6 0.7 2.0 -1.1 1.4 0.7 -0.1 -0.7 -0.4
Medication: Cholesterol lowering 0.4 0.7 2.6 -1.6 0.1 -1.1 -0.3 0.3 0.3
Depression (self-reported) 1.2 1.5 3.3 0.4 1.8 -1.8 -0.7 -1.4 -0.0
Medication: Lansoprazole 1.2 1.3 2.5 1.4 0.3 -0.6 -1.6 -1.4 -1.1
Prospective memory result 0.8 1.0 2.6 0.1 1.0 -0.9 -0.9 -0.9 1.6
Lung cancer (father) 0.2 0.3 1.1 -0.1 1.1 0.2 0.2 0.3 0.4
Illnesses of mother 2.1 2.6 8.3 -0.8 -2.9 -0.6 -1.3 -0.7 -1.9
Forced expiratory volume in 1-second (FEV1), Best measure 1.1 3.6 9.3 0.3 -0.7 3.1 2.6 2.1 -0.7
Pulse wave Arterial Stiffness index 0.4 0.5 1.8 0.2 0.0 1.4 0.7 0.3 -0.7
Impedance of arm (left) 0.2 1.1 2.8 1.4 -0.8 -1.7 -0.9 -0.5 0.5
Arm fat mass (right) 1.3 5.3 13.0 -0.9 -0.6 2.7 3.6 3.2 0.6
Trunk predicted mass 2.7 15.4 39.9 0.2 -1.7 3.8 6.3 5.9 0.1
Standing height 2.5 24.7 60.4 1.2 -3.6 3.8 7.8 7.7 -0.1
Length of working week for main job 0.2 0.2 0.6 0.3 0.4 0.6 0.4 -0.1 0.7
Exposure to tobacco smoke at home 0.9 1.0 2.0 -1.4 -0.4 1.1 0.9 1.2 0.0
Breastfed as a baby 2.1 2.6 6.1 -0.9 0.4 0.8 2.0 2.5 2.0
Tense / ‘highly strung’ 0.4 0.6 3.4 0.0 -0.0 -1.8 -0.3 0.5 0.4
Seen doctor (GP) for nerves, anxiety, tension or depression 0.6 0.8 2.7 -1.4 -0.1 -0.2 -0.1 0.5 -1.6
Hair/balding pattern: Pattern 4 0.2 0.6 0.9 -0.8 -0.9 0.5 0.5 0.9 -0.8
Birth weight of first child 0.8 1.5 7.7 -2.8 0.5 -0.9 0.1 -0.0 -0.2
Peak expiratory flow (PEF) 1.9 4.5 13.1 -1.5 0.0 3.6 2.6 2.2 0.2
Pulse wave reflection index 1.1 1.3 4.0 0.8 2.0 0.1 -0.6 -1.4 1.0
Ever highly irritable/argumentative for 2 days 1.5 1.8 4.0 -1.3 2.0 -0.2 1.2 1.3 1.4
Loud music exposure frequency 3.2 3.4 17.9 -0.4 -0.2 4.2 1.5 0.3 0.6
Qualifications: O levels/GCSEs or equivalent 0.2 0.3 0.6 -0.8 -0.1 0.8 0.4 0.4 0.6
Mouth/teeth dental problems: Bleeding gums 3.5 4.6 8.6 -0.3 -0.4 2.9 2.9 2.9 1.3
Blood clot in the leg (DVT) 1.3 1.7 5.6 -0.0 2.1 -0.6 -0.1 0.0 2.4
Medication: Paracetamol 0.4 0.6 2.6 -1.6 0.9 0.5 0.3 -0.1 0.2
Headache pain in last month 0.7 1.3 2.9 -1.3 -0.4 1.1 1.0 1.7 -0.9
Medication for cholesterol, blood pressure or diabetes 0.7 1.2 4.0 1.4 -0.6 2.0 0.2 -0.9 -0.4
Glaucoma (self-reported) 2.1 2.5 5.9 -1.5 -2.4 0.0 1.0 1.2 -2.1
Gout (self-reported) 0.4 0.6 1.4 0.1 -0.5 0.1 -1.2 -1.1 -0.7
Hypothyroidism/myxoedema (self-reported) 0.4 0.7 1.8 0.0 -0.4 -0.6 1.3 1.3 -0.6
Medication: Amlodipine 1.2 1.7 5.0 0.7 2.2 -1.7 0.9 0.9 0.1
Medication: Ventolin 100micrograms inhaler 0.6 0.8 2.0 1.4 -1.0 0.1 0.3 -0.2 -1.2
Birth weight 0.2 0.4 1.0 -0.8 -0.0 -0.9 -1.0 -0.4 0.3
Chronic bronchitis/emphysema (mother) 0.9 1.0 3.8 -0.0 1.4 0.6 -0.0 -0.3 1.9
High blood pressure (siblings) 0.5 0.7 1.6 -1.0 0.9 1.2 0.8 -0.0 -0.4
Forced vital capacity (FVC), Best measure 1.4 5.2 11.6 0.9 -1.5 2.5 3.4 3.0 -1.1
Body fat percentage 0.8 3.3 6.0 -0.9 -0.6 2.4 2.5 2.4 0.9
Leg fat percentage (right) 0.7 2.5 7.6 -1.1 -0.3 2.8 1.9 1.6 0.6
Arm fat-free mass (right) 2.8 14.3 35.1 -0.6 -1.5 4.4 5.9 5.4 0.3
Exposure to tobacco smoke outside home 0.3 0.4 2.2 0.2 1.5 0.3 -0.4 -0.3 -0.0
Comparative body size at age 10 1.6 4.4 11.1 1.3 1.3 -1.1 -3.3 -3.1 1.1
Number of full brothers 1.2 1.5 4.5 0.5 2.1 -0.3 0.3 0.2 2.0
Worry too long after embarrassment 0.3 0.4 0.8 -0.9 -0.5 -0.9 -0.7 -0.2 -0.4
Seen a psychiatrist for nerves, anxiety, tension or depression 0.2 0.3 0.9 0.2 0.7 0.2 -0.2 0.2 -0.9
Wheeze or whistling in the chest in last year 0.3 0.5 1.2 0.8 -0.5 0.9 1.1 0.4 -0.3
Number of children fathered 2.4 2.7 8.3 -0.2 -2.9 -0.8 -0.2 0.1 -2.7
Reason for reducing amount of alcohol drunk: Health precaution 0.3 0.3 1.1 0.9 -0.2 0.3 -0.0 0.1 1.0
Age at first live birth 0.5 0.8 2.0 -1.4 -1.1 1.1 -0.4 -0.4 -0.3
Pulse wave peak to peak time 0.4 0.4 1.2 0.2 -0.2 -1.0 -0.0 0.4 1.1
Health satisfaction 0.9 1.2 3.7 -1.9 0.6 -1.4 -1.0 -0.3 0.1
Shortness of breath walking on level ground 0.8 0.9 3.8 -2.0 0.9 -0.7 -0.1 -0.2 -0.6
Qualifications: College or University degree 0.7 2.4 11.2 0.5 0.3 -0.6 1.0 1.2 3.3
Eye problems/disorders: None of the above 0.7 0.8 2.0 1.0 1.4 0.9 -0.5 -0.7 0.2
Mouth/teeth dental problems: Loose teeth 0.2 0.2 0.9 -0.3 0.9 0.2 0.4 0.3 0.4
Emphysema/chronic bronchitis 2.8 3.1 9.6 -1.3 -1.5 -3.1 -1.8 -0.8 -1.1
Medication for pain relief, constipation, heartburn 0.4 0.8 1.3 1.1 -1.1 -0.8 -1.0 -0.5 0.0
Neck or shoulder pain in last month 0.1 0.2 0.4 0.4 0.3 0.2 -0.6 -0.4 0.3
Medication: Blood pressure 1.0 1.8 5.1 0.4 1.4 -0.6 1.4 2.3 1.0
Angina (self-reported) 0.4 0.5 1.2 -1.1 0.3 -0.4 0.8 0.4 -0.9
Migraine (self-reported) 0.1 0.1 0.6 0.8 0.0 0.2 0.3 -0.0 0.1
Medication: Ibuprofen 0.6 0.7 2.6 -0.6 1.6 0.6 0.0 -0.9 -0.1
Medication: Allopurinol 0.4 0.5 0.8 -0.6 -0.9 -0.8 -0.9 -0.6 -0.3
Medication: Omeprazole 0.4 0.4 2.2 -0.1 1.5 0.1 0.3 0.3 -0.5
Medication: Seretide 50 evohaler 0.7 0.8 2.4 0.5 -0.2 -0.6 1.2 1.5 0.7
Mean time to correctly identify matches 0.2 0.4 1.3 0.2 0.9 -1.1 0.0 0.1 -0.2
Heart disease (mother) 1.6 2.0 6.0 0.5 0.5 0.1 2.5 2.2 0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria 2.2 2.7 4.9 0.2 2.2 -0.8 -1.9 -2.2 1.5
Whole body fat mass 1.7 7.2 15.9 -1.1 -1.0 3.2 4.0 3.7 0.8
Leg fat mass (right) 1.8 6.8 14.1 -1.3 -0.8 3.5 3.7 3.4 0.6
Arm predicted mass (right) 2.6 13.4 31.9 -0.4 -1.6 4.4 5.6 5.1 0.4
Pulse rate, automated reading 1.4 4.7 11.2 -1.3 -1.8 1.1 3.1 3.3 -0.9
Alcohol intake frequency. 0.8 1.9 6.8 0.3 1.5 2.6 0.4 0.1 1.5
Comparative height size at age 10 2.1 11.3 25.8 2.1 -1.9 2.2 5.1 5.1 2.0
Number of full sisters 1.9 2.3 4.5 -1.0 1.5 -1.5 -1.9 -2.1 0.3
Suffer from ‘nerves’ 0.4 0.7 1.9 1.4 0.6 -0.6 -0.8 -0.8 0.3
Overall health rating 0.4 0.8 2.9 0.8 1.7 -0.7 -0.7 -0.7 -0.5
Chest pain or discomfort 1.5 2.2 5.4 0.7 2.3 -0.7 1.4 1.2 1.9
Had major operations 1.1 1.3 2.7 -0.7 0.4 -1.3 -1.6 -1.5 0.4
Age at last live birth 0.7 1.0 2.1 -1.3 -1.5 -0.8 -0.8 -0.2 -1.0
Family relationship satisfaction 0.5 0.6 1.0 -0.6 0.9 -0.6 -0.8 -0.4 1.0
Leg pain on walking 1.4 1.7 3.4 -0.7 1.8 -1.6 -1.3 -1.4 0.2
Qualifications: NVQ or HND or HNC or equivalent 0.6 0.8 2.5 -0.9 -1.0 0.1 0.1 -0.4 -1.6
Commuting to job workplace: Car/motor vehicle 0.8 0.9 1.6 -1.2 0.7 0.9 0.9 1.3 0.2
Illness, injury, bereavement, stress in last 2 years 0.4 0.5 0.9 0.9 -0.0 0.7 -0.6 -0.8 0.8
Medication: Aspirin 0.5 0.6 1.1 -1.0 0.4 -0.9 0.8 1.0 0.2
Supplements: Vitamin C 0.5 0.6 2.0 1.4 0.3 -0.5 -0.3 -0.4 1.1
Knee pain experienced in last month 0.9 1.4 3.0 -1.5 -1.0 0.9 0.9 0.9 -1.7
Hypertension (Self-reported) 1.6 4.6 7.7 -0.5 2.5 -0.9 2.6 2.8 2.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.5 0.6 1.4 0.1 -0.2 -1.1 -0.9 -0.5 -1.2
Illnesses of father: Heart disease 0.9 1.3 2.8 -0.9 -0.6 -1.7 0.4 1.4 -1.2
Illnesses of siblings: Diabetes 0.8 0.9 3.1 -1.2 0.1 -0.5 -0.8 -0.4 -1.8
Smoking status: Previous 0.4 0.6 1.4 -0.9 -0.0 -0.8 0.7 1.2 -0.2
Forced expiratory volume in 1-second (FEV1), predicted 0.6 1.2 2.3 1.1 0.1 0.9 1.5 1.4 -0.9
Whole body fat-free mass 2.8 16.1 41.3 -0.4 -1.6 4.0 6.4 6.0 0.3
Leg fat-free mass (right) 2.7 14.4 36.8 -1.1 -1.0 3.7 6.1 5.8 0.6
Arm fat percentage (left) 0.6 2.3 3.8 -1.3 0.0 1.9 2.0 1.9 1.0
Average weekly red wine intake 0.5 0.7 2.2 -0.1 0.2 -0.5 0.9 1.0 1.5
Handedness (chirality/laterality): Left-handed 0.4 0.5 0.7 -0.7 0.6 -0.8 -0.8 -0.7 0.3
Mood swings 0.8 1.4 3.5 1.9 1.4 -1.4 0.8 0.5 -0.5
Loneliness, isolation 1.1 1.5 5.6 -0.1 -0.1 -1.1 -2.4 -1.5 0.3
Long-standing illness, disability or infirmity 0.3 0.4 1.0 -0.5 -0.1 0.3 -0.9 -0.8 -1.0
Ever had bowel cancer screening 0.5 0.6 2.8 -0.5 1.7 0.0 -0.3 -0.7 0.1
Diabetes diagnosed by doctor 0.4 0.7 1.8 -1.4 -0.3 0.3 -0.3 -0.5 -1.3
Ever had stillbirth, spontaneous miscarriage or termination 0.4 0.4 0.9 0.6 1.0 -0.2 -0.2 -0.4 0.9
Friendships satisfaction 0.6 0.7 2.3 -1.5 -0.5 -0.6 -0.1 1.0 0.7
Qualifications: nursing, teaching 0.7 1.1 3.1 1.4 -0.9 1.8 0.3 0.3 -0.7
Commuting to job workplace: Walk 1.3 1.4 4.2 1.5 0.2 -2.1 -0.7 -1.1 -0.3
Eye problems/disorders: Cataract 1.3 1.5 3.5 0.2 -0.5 -1.9 1.4 1.6 1.0
Mouth/teeth dental problems: Mouth ulcers 1.5 2.3 4.0 1.0 1.3 2.0 1.8 1.1 1.7
Medication for cholesterol 2.0 3.0 6.3 -1.3 -1.9 -1.4 -2.5 -1.7 -1.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.7 0.9 2.7 1.6 0.3 0.3 -0.8 -1.2 0.5
Back pain experienced in last month 0.2 0.2 0.8 -0.4 0.2 0.1 0.9 0.6 0.0
Mineral and other dietary supplements 0.4 0.5 1.0 0.9 -0.7 0.4 1.0 0.7 -0.1
Breast cancer (self-reported) 1.5 1.8 3.5 -1.4 -1.2 0.7 1.7 1.9 -0.6
Asthma (self-reported) 0.9 1.9 5.5 1.3 1.1 0.2 2.3 1.5 0.7
Osteoporosis (self-reported) 2.4 3.0 8.4 0.0 0.2 1.4 2.9 2.8 0.2
Osteoarthritis (self-reported) 1.4 1.9 4.0 -0.6 -0.7 -1.3 -1.6 -1.5 -2.0
Medication: Aspirin 0.4 0.5 1.2 -1.1 0.4 -0.7 0.5 0.8 0.0
Medication: Gliclazide 0.4 0.5 1.8 -0.1 0.6 -0.2 -0.5 -0.7 -1.3
Illnesses of father: None of the above (group 1) 2.2 2.7 6.5 2.5 2.3 -0.0 -0.9 -1.4 1.2
Smoking status: Current 2.6 4.1 8.8 1.3 -0.8 -3.0 -2.5 -2.3 -1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.9 1.9 3.8 -1.9 -1.2 1.9 0.3 0.4 -1.4
Whole body water mass 2.7 15.5 40.2 -0.4 -1.4 3.9 6.3 5.9 0.3
Leg predicted mass (right) 2.6 13.9 35.8 -1.1 -0.9 3.6 6.0 5.7 0.5
Arm fat mass (left) 1.3 5.3 12.2 -1.0 -0.4 2.8 3.5 3.1 1.0
Number of self-reported non-cancer illnesses 0.7 1.2 5.6 -0.6 2.4 -0.9 0.4 0.2 0.3
Average weekly champagne plus white wine intake 1.0 1.4 4.0 -2.0 -1.6 -0.9 0.6 0.7 -0.6
Miserableness 0.2 0.4 0.8 -0.2 0.0 0.9 0.5 0.7 0.8
Guilty feelings 0.9 1.4 3.7 0.5 0.6 -1.9 -1.3 -1.3 -0.6
Wears glasses or contact lenses 2.0 2.3 5.0 -2.2 -0.0 1.1 1.5 1.8 1.4
Ever taken oral contraceptive pill 1.1 1.2 2.4 -1.3 0.9 -0.0 1.0 1.5 1.2
Hearing aid user 1.7 1.9 4.5 -0.8 -2.1 0.6 1.7 1.3 -1.1
Mother’s age at death 1.4 1.8 3.6 -1.4 -0.4 -1.3 -1.9 -1.2 -1.4
Financial situation satisfaction 1.0 1.3 4.9 0.2 2.2 0.1 0.9 0.7 1.2
Tinnitus: Yes, now most or all of the time 0.7 0.8 2.0 -1.1 1.0 -1.4 -0.5 -0.4 -0.5
Commuting to job workplace: Public transport 0.6 0.7 2.6 0.8 -1.6 -0.4 -0.4 -0.1 -0.7
Eye problems/disorders: Glaucoma 3.0 3.6 10.6 -0.8 -3.3 -1.0 0.2 0.5 -3.0
Medication: Blood pressure 1.1 2.2 4.3 -0.3 2.0 -0.3 1.7 1.3 2.1
Pain type(s) experienced in last month: Hip pain 0.1 0.1 0.4 -0.6 -0.0 -0.3 0.4 0.3 -0.1
Supplements: Fish oil (including cod liver oil) 0.3 0.4 1.9 -1.4 0.1 -0.3 -0.3 0.2 0.4
High cholesterol (Self-reported) 0.4 0.6 3.0 -1.7 0.8 0.3 -0.1 0.0 0.2
Medication: Bendroflumethiazide 0.7 1.0 2.7 0.6 0.4 0.5 1.6 1.6 0.2
Medication: Paracetamol 0.3 0.5 1.2 -1.1 0.6 1.0 0.3 -0.4 0.2
Medication: Lisinopril 1.3 1.7 3.9 1.4 2.0 -0.3 0.5 0.5 1.9
Medication: Atorvastatin 0.4 0.5 1.2 0.5 0.3 1.1 0.9 0.3 0.5
Illnesses of father: High blood pressure 1.1 1.4 3.5 -0.6 1.2 -1.5 0.8 0.6 1.9
Alcohol drinker status: Never 1.1 1.4 2.4 -0.1 1.4 0.3 1.3 1.6 1.4
Ever smoked 0.4 0.7 2.7 0.7 -0.3 -1.6 -0.4 -0.2 -0.8
Basal metabolic rate 2.9 15.8 40.6 -0.6 -1.5 4.1 6.4 5.9 0.3
Leg fat percentage (left) 1.0 3.6 9.9 -1.1 -0.4 3.1 2.4 2.1 0.4
Arm fat-free mass (left) 2.7 14.0 35.2 -0.4 -1.6 4.1 5.9 5.3 -0.0
Number of operations (self-reported) 0.9 1.4 2.0 -1.4 -1.1 -1.3 -1.1 -0.6 -1.4
Average weekly beer plus cider intake 0.5 0.7 1.8 -0.6 -0.7 0.0 -0.7 -0.9 -1.3
Irritability 0.9 1.5 6.5 2.5 0.6 -0.2 0.5 0.8 1.2
Risk taking 1.1 1.6 5.9 2.4 1.0 -0.4 -0.2 -0.6 1.4
Ever had prostate specific antigen (PSA) test 0.3 0.4 0.8 -0.1 -0.6 -0.9 -0.9 -0.1 0.6
Fractured/broken bones in last 5 years 1.5 2.0 4.4 -0.4 -0.6 2.0 2.1 1.6 0.6
Age started oral contraceptive pill 2.1 2.7 6.3 1.7 0.4 0.6 2.5 2.0 1.5
Diastolic blood pressure, automated reading 1.0 3.2 9.1 -2.1 0.5 -0.2 2.1 3.0 0.9
Ever depressed for a whole week 1.2 1.5 4.2 -1.2 0.5 -2.1 -0.5 -0.1 -1.6
Unable to work because of sickness or disability 1.0 1.2 2.3 1.0 1.3 -0.6 -1.4 -1.5 -0.0
Commuting to job workplace: Cycle 2.0 2.4 5.6 -0.2 -1.2 1.4 2.4 2.1 0.7
Myopia 1.4 2.0 5.8 0.7 1.1 -0.0 -2.2 -2.4 -0.0
Vascular/heart problems diagnosed by doctor 1.6 4.3 6.8 0.5 -2.6 0.5 -2.4 -2.4 -2.6
Cholesterol lowering medication 0.4 0.6 2.6 -0.5 1.6 0.2 0.7 -0.2 -0.1
Medication: Omeprazole (e.g. Zanprol) 0.4 0.4 2.1 0.0 1.4 0.4 0.2 0.3 -0.5
Pain experienced in last month 0.2 0.3 0.8 0.9 -0.1 -0.7 0.5 0.1 0.7
Supplements: Calcium 0.3 0.4 0.7 -0.8 0.4 -0.9 -0.7 -0.0 -0.3
Basal cell carcinoma (self-reported) 0.9 1.0 1.7 -1.2 0.5 -1.1 0.9 1.3 0.9
Heart attack/myocardial infarction (self-reported) 0.5 0.6 1.9 -0.1 1.0 1.4 -0.0 -0.6 -0.3
Deep venous thrombosis (DVT) (self-reported) 1.1 1.5 5.4 -0.1 1.8 -0.4 -0.0 0.2 2.3
Heart disease (siblings) 1.0 1.3 2.2 -1.5 0.5 -0.8 -1.4 -0.9 -1.3
Alcohol drinker status: Previous 1.1 1.2 4.8 2.2 0.1 -1.2 -0.3 -0.6 0.9
Pack years of smoking 0.1 0.2 0.5 0.0 -0.6 0.7 -0.4 -0.4 0.3
Impedance of whole body 0.4 1.8 3.7 1.9 -1.3 -1.2 -1.5 -1.3 -0.2
Leg fat mass (left) 2.1 8.1 16.6 -1.4 -0.8 3.8 4.1 3.8 0.6
Arm predicted mass (left) 2.8 14.1 35.5 -0.2 -1.7 4.2 6.0 5.4 -0.0