Best TWAS P=1.48e-10 · Best GWAS P=8.98e-12 conditioned to 0.000444
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | MARVELD3 | 0.07 | 0.05 | lasso | 3 | 0.09 | 5.7e-11 | -6.1 | -5.6 | 1.8e-08 | 0.57 | 0.29 | 0.71 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | PHLPP2 | 0.04 | 0.01 | bslmm | 456 | 0.02 | 4.7e-04 | -4.9 | -6.4 | 1.5e-10 | 0.65 | 0.26 | 0.69 | TRUE |
| 3 | GTEx | Adipose Subcutaneous | AP1G1 | 0.08 | 0.05 | enet | 17 | 0.06 | 1.0e-05 | -5.4 | -5.2 | 2.4e-07 | 0.64 | 0.25 | 0.74 | FALSE |
| 4 | GTEx | Adrenal Gland | AP1G1 | 0.22 | 0.06 | enet | 25 | 0.14 | 8.0e-06 | -6.0 | -6.0 | 2.4e-09 | 0.60 | 0.21 | 0.75 | FALSE |
| 5 | GTEx | Artery Tibial | AP1G1 | 0.07 | 0.06 | lasso | 6 | 0.06 | 1.0e-05 | -3.3 | -5.1 | 3.0e-07 | 0.65 | 0.37 | 0.63 | FALSE |
| 6 | GTEx | Testis | PHLPP2 | 0.29 | 0.38 | enet | 20 | 0.37 | 3.0e-17 | -6.1 | 6.0 | 2.0e-09 | -0.70 | 0.25 | 0.75 | FALSE |
| 7 | YFS | Blood | PHLPP2 | 0.04 | 0.03 | bslmm | 459 | 0.05 | 5.5e-16 | -6.0 | 5.4 | 5.5e-08 | -0.56 | 0.31 | 0.69 | FALSE |
| 8 | The Cancer Genome Atlas | Esophageal Carcinoma | PHLPP2 | 0.18 | 0.03 | blup | 67 | 0.07 | 2.9e-03 | -6.1 | -5.4 | 7.4e-08 | 0.62 | 0.05 | 0.30 | FALSE |
| 9 | The Cancer Genome Atlas | Prostate Adenocarcinoma | AP1G1 | 0.11 | 0.02 | enet | 27 | 0.04 | 1.2e-04 | 3.0 | -5.3 | 1.4e-07 | 0.22 | 0.08 | 0.24 | FALSE |