Best TWAS P=8.61e-08 · Best GWAS P=2.69e-07 conditioned to 0.146
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Visceral Omentum | GGNBP2 | 0.13 | 0.12 | enet | 11 | 0.13 | 1.9e-07 | -4.7 | -5.3 | 8.6e-08 | -0.80 | 0.03 | 0.96 | TRUE |
| 3 | GTEx | Esophagus Mucosa | GGNBP2 | 0.16 | 0.16 | enet | 15 | 0.18 | 3.1e-12 | -4.4 | -5.3 | 1.3e-07 | -0.88 | 0.03 | 0.96 | FALSE |
| 4 | GTEx | Esophagus Mucosa | DHRS11 | 0.12 | 0.08 | lasso | 2 | 0.06 | 5.1e-05 | 5.1 | 5.3 | 1.5e-07 | 0.97 | 0.02 | 0.98 | FALSE |
| 7 | NTR | Blood | GGNBP2 | 0.03 | 0.02 | bslmm | 331 | 0.02 | 7.7e-07 | -4.4 | -5.2 | 1.7e-07 | -0.79 | 0.03 | 0.96 | FALSE |
| 8 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | ZNHIT3 | 0.05 | 0.03 | enet | 4 | 0.04 | 4.7e-05 | 5.1 | 5.2 | 1.7e-07 | 0.97 | 0.01 | 0.99 | FALSE |
| 2 | GTEx | Cells EBV-transformed lymphocytes | ZNHIT3 | 0.31 | 0.32 | enet | 9 | 0.22 | 1.1e-07 | 5.1 | 5.2 | 2.3e-07 | 0.92 | 0.01 | 0.99 | FALSE |
| 5 | GTEx | Lung | GGNBP2 | 0.08 | 0.01 | enet | 8 | 0.01 | 3.3e-02 | 5.1 | -5.2 | 2.6e-07 | -0.93 | 0.02 | 0.97 | FALSE |
| 6 | METSIM | Adipose | GGNBP2 | 0.16 | 0.14 | lasso | 5 | 0.14 | 6.2e-21 | 5.1 | -5.1 | 3.0e-07 | -0.92 | 0.01 | 0.98 | FALSE |