Hub : Genes

ZNHIT3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells EBV-transformed lymphocytes	0.3140	0.0920	5.5e-05	0.315	NA	0.218	NA	0.128	6.1e-11	NA	1.1e-07	NA	6.0e-05
2	GTEx	Cells Transformed fibroblasts	0.1510	0.0520	9.1e-05	0.070	NA	0.040	NA	0.048	5.6e-06	NA	5.3e-04	NA	1.8e-04
3	GTEx	Esophagus Mucosa	0.2150	0.0530	1.1e-07	0.127	NA	0.077	NA	0.011	8.5e-09	NA	8.1e-06	NA	5.5e-02
4	GTEx	Testis	0.2680	0.0620	4.5e-08	0.326	NA	0.286	NA	0.321	4.2e-15	NA	3.9e-13	NA	8.0e-15
5	YFS	Blood	0.0924	0.0186	1.8e-14	0.048	0.055	0.071	0.069	0.074	2.6e-15	2.6e-17	2.4e-22	1.2e-21	5.8e-23
6	TCGA	Breast Invasive Carcinoma	0.0134	0.0093	3.1e-03	0.005	0.009	0.005	NA	0.009	2.9e-02	4.7e-03	2.8e-02	NA	4.2e-03
7	TCGA	Esophageal Carcinoma	0.1050	0.0670	3.8e-03	0.109	0.065	0.078	NA	0.095	2.6e-04	4.2e-03	1.8e-03	NA	6.2e-04
8	TCGA	Head and Neck Squamous Cell Carcinoma	0.0517	0.0314	4.7e-05	0.033	0.033	0.037	NA	0.023	1.1e-04	1.2e-04	4.7e-05	NA	1.1e-03
9	TCGA	Kidney Renal Clear Cell Carcinoma	0.0271	0.0198	7.7e-03	0.008	0.007	0.003	NA	0.003	4.2e-02	5.3e-02	1.4e-01	NA	1.2e-01
10	TCGA	Lung Squamous Cell Carcinoma	0.0254	0.0164	2.3e-03	0.031	0.024	0.031	NA	0.028	1.7e-04	8.3e-04	1.8e-04	NA	3.1e-04
11	TCGA	Pancreatic Adenocarcinoma	0.1940	0.1200	4.0e-04	-0.006	0.051	0.096	NA	0.040	8.1e-01	3.5e-03	8.2e-05	NA	8.9e-03
12	TCGA	Stomach Adenocarcinoma	0.0630	0.0400	7.7e-04	0.033	0.022	0.035	NA	0.027	1.8e-03	9.2e-03	1.3e-03	NA	4.7e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Bipolar Disorder (2018)	3.9	6.2	10.0	-2.7	-2.8	-3.2	2.9	1.8	-1.9	-2.5	-2.6	-1.1	-2.4	-2.6	-2.6
Bipolar Disorder or Schizophrenia	4.7	11.6	15.4	-3.9	-3.8	-3.9	3.9	2.7	-3.0	-3.3	-3.7	-1.9	-3.3	-3.2	-3.6
Depressed Affect (Nagel 2018)	1.0	2.2	4.3	-1.2	-1.8	-1.5	1.4	0.5	-1.7	-1.3	-1.6	-2.1	-1.5	-0.3	-1.7
Depression (Nagel 2018)	4.4	6.7	11.1	-2.5	-3.1	-2.6	2.4	0.8	-2.0	-2.9	-3.3	-2.4	-3.2	-1.1	-3.2
Intelligence (Savage-Jansen 2018)	9.1	28.0	37.1	-6.1	-5.9	-5.9	5.9	3.9	-4.9	-5.4	-6.0	-3.8	-5.8	-3.3	-5.7
Neuroticism (Nagel 2018)	2.3	5.3	7.6	-2.5	-2.6	-2.4	2.6	1.7	-2.8	-2.1	-2.5	-2.5	-2.2	-1.0	-2.4
Schizophrenia (2018)	2.7	5.7	8.4	-2.9	-2.7	-2.4	2.7	1.9	-2.3	-2.3	-2.6	-1.6	-2.3	-2.1	-2.6
Schizophrenia vs Biploar Disorder	0.1	0.2	0.6	-0.4	0.3	0.2	0.1	-0.5	0.3	-0.8	-0.3	0.1	-0.8	-0.3	-0.5
Worry (Nagel 2018)	2.5	5.3	8.2	-2.7	-2.9	-2.2	2.7	2.2	-2.7	-1.8	-2.4	-1.9	-1.9	-1.5	-2.2
Alzheimer’s Disease (in mother)	1.8	2.1	3.1	-1.7	-1.7	-1.7	1.6	1.4	-1.8	-1.1	-1.7	-1.4	-1.3	-0.4	-1.3
Alzheimer’s Disease (in father)	1.6	1.7	3.3	-1.6	-1.4	-0.4	1.7	1.3	-0.8	-1.3	-1.5	0.1	-1.4	-1.8	-1.3
Alzheimer’s Disease (including proxy)	1.6	2.3	3.3	-1.8	-1.8	-1.1	1.8	1.7	-1.7	-1.2	-1.8	-0.9	-1.5	-1.4	-1.4
Crohns Disease (2017)	0.3	0.6	1.3	0.4	0.5	1.1	-0.6	-0.1	0.9	0.9	0.8	1.0	0.8	-0.3	1.0
Irritable Bowel Disease (IBD)	1.4	3.4	7.0	1.9	1.7	1.9	-1.7	-0.6	0.9	2.6	2.1	0.7	2.6	1.7	2.3
Ulcerative Colitis (UC)	2.8	5.2	9.2	2.5	2.4	2.2	-2.3	-1.2	1.2	3.0	2.4	0.7	3.0	2.5	2.6
Major Depression (MDD)	0.4	0.5	1.7	-0.2	0.3	-0.0	-0.0	-1.3	-0.0	-1.0	-0.2	-1.1	-0.8	-0.2	-1.0
Reaction Time	0.1	0.1	0.7	-0.2	-0.1	0.1	0.2	0.9	-0.4	0.3	0.2	0.3	0.4	-0.3	0.2
Verbal and Numeric Reasoning (VNR)	11.3	27.1	36.1	-5.9	-5.8	-5.4	5.7	3.6	-4.8	-5.5	-6.0	-3.9	-5.7	-3.3	-5.8
Breast Cancer	0.5	1.1	2.8	-0.9	-0.6	-1.1	0.7	-0.5	0.0	-1.7	-1.3	-0.6	-1.6	-0.6	-1.5
Ovarian Cancer	0.3	0.4	1.3	0.5	0.5	0.7	-0.6	-1.1	0.9	-0.3	-0.3	0.2	-0.2	1.2	-0.3
Prostate Cancer	0.4	0.5	2.4	0.2	0.5	-0.3	-0.2	-1.6	0.3	-1.0	-0.0	-0.9	-0.7	-0.4	-0.9
Age at First Birth	0.6	0.9	3.4	-0.9	-0.6	0.1	0.7	0.6	0.7	-0.6	-0.5	1.9	-0.8	-1.8	-0.0
Bipolar Disorder (2011)	1.5	1.4	6.5	-1.1	-1.3	-1.6	1.0	0.4	0.1	-1.2	-0.6	0.5	-1.2	-2.5	-0.9
Body Mass Index (BMI) (2010)	7.8	10.7	16.0	3.8	3.2	3.3	-3.2	-1.3	2.7	3.9	3.8	2.7	3.9	2.3	4.0
Coronary Artery Disease (CAD)	2.7	3.2	5.7	2.0	2.4	2.3	-2.2	-1.7	1.5	1.4	1.5	1.4	1.5	1.6	1.6
Crohns Disease (2012)	0.4	0.6	2.0	0.6	0.5	1.4	-0.6	-0.5	0.8	0.7	1.0	0.7	0.6	-0.9	0.8
Mean Putamen Volume	0.5	0.6	1.8	0.7	0.8	0.6	-0.4	-0.4	1.2	0.4	0.7	1.4	0.5	-0.8	0.8
Fasting Glucose	2.0	2.4	4.2	1.6	1.4	0.7	-1.7	-0.6	1.2	1.8	1.9	1.4	2.0	1.3	2.0
HbA1C	1.2	1.4	4.3	1.3	1.1	1.1	-1.2	0.1	0.1	2.1	1.7	-0.1	1.9	-0.0	0.3
HDL Cholesterol	0.2	0.4	1.6	0.1	0.3	0.6	-0.5	-0.2	1.0	-0.4	0.0	1.3	-0.2	-0.9	0.0
LDL Cholesterol	1.7	2.7	5.3	1.4	1.8	1.5	-1.3	-0.7	1.9	1.7	1.7	2.3	1.8	0.8	2.0
Lupus	0.1	0.1	0.7	-0.1	-0.3	0.3	0.2	-0.1	-0.4	-0.1	-0.2	-0.8	-0.1	0.7	-0.3
Neuroticism (2016)	1.7	2.5	4.1	-1.7	-2.0	-1.9	1.7	0.8	-0.9	-1.8	-1.9	-0.6	-1.8	-1.2	-1.8
Primary Biliary Cirrhosis	3.5	5.0	8.5	2.2	2.4	2.5	-2.1	-0.7	1.4	2.9	2.8	1.4	2.9	1.4	2.8
Rheumatoid Arthritis	0.2	0.3	0.6	0.8	0.7	0.6	-0.6	-0.6	0.4	0.5	0.6	-0.0	0.7	0.6	0.4
Schizophrenia (2014)	3.5	7.6	11.3	-3.1	-2.8	-2.9	2.9	1.8	-2.7	-2.9	-3.4	-2.3	-3.1	-1.6	-3.2
Triglycerides	2.8	4.6	7.6	2.1	2.5	2.4	-1.7	-1.0	1.5	2.6	2.6	1.2	2.8	2.0	2.4
Type 2 Diabetes (T2D) (2012)	1.0	1.2	4.1	1.5	1.1	0.6	-1.5	-1.1	-0.0	0.8	0.9	-0.9	0.7	2.0	0.6
Ulcerative Colitis	2.1	3.0	6.7	1.8	1.8	1.6	-1.4	-1.0	-0.0	2.2	1.9	-1.0	2.3	2.6	1.6
Blood Eosinophil Count	1.9	14.4	36.7	-4.4	-5.0	-3.4	4.9	6.1	-4.4	-1.9	-3.3	-1.1	-2.4	-3.1	-2.3
Blood Platelet Count	0.1	0.9	5.4	-0.8	-0.7	-0.7	0.5	-0.6	0.5	-1.2	-0.5	0.4	-0.9	-2.3	-0.9
Blood Red Count	0.1	1.4	8.2	0.9	0.9	0.6	-1.0	-2.9	1.1	-1.3	-0.1	-0.9	-1.0	-0.1	-1.0
Blood White Count	0.3	2.0	3.1	1.8	1.6	1.0	-1.6	-1.3	1.5	1.2	1.7	1.3	1.2	0.6	1.5
Heel T-Score	0.1	0.4	1.7	-0.3	0.2	-0.2	-0.0	-0.2	1.0	-0.7	-0.3	1.3	-0.7	-1.1	-0.1
BMI	9.0	52.4	77.4	8.3	7.6	7.0	-8.0	-4.8	5.8	8.1	8.8	4.3	8.4	5.6	8.2
Height	0.3	6.1	11.5	-2.4	-2.4	-2.3	2.0	-0.1	-2.0	-3.2	-3.0	-2.9	-3.1	-0.8	-3.4
Waist Hip Ratio (WHR)	3.1	13.8	20.2	4.4	4.4	4.5	-4.3	-3.5	4.0	3.1	3.7	2.7	3.2	2.4	3.6
Systolic Blood Pressure	1.0	5.1	8.2	2.3	2.7	2.5	-2.4	-1.8	1.1	2.6	2.9	0.2	2.8	1.8	2.5
Smoking Status	1.5	3.7	5.6	2.2	1.8	1.6	-2.2	-2.0	2.2	1.8	2.4	1.5	1.9	0.8	2.0
Allergy or Eczema	8.3	21.9	33.8	-5.4	-5.8	-5.1	5.3	4.5	-4.5	-4.3	-5.0	-2.4	-4.8	-3.7	-4.4
Cardiovascular Disease	2.6	8.7	12.2	3.4	3.4	3.0	-3.2	-3.1	3.1	2.7	3.5	1.8	3.2	1.4	2.8
Hypothyroidism (self reported)	1.1	2.6	4.4	-1.7	-2.0	-1.9	1.4	0.8	-0.2	-2.0	-1.9	0.2	-2.1	-1.9	-1.5
Respiratory disease	2.7	6.0	10.6	-2.9	-2.4	-2.2	2.6	1.9	-1.3	-2.8	-3.2	-0.1	-3.1	-2.5	-2.5
Type 2 Diabetes (T2D) (2018)	1.9	3.5	5.8	1.8	2.1	2.3	-1.9	-1.8	2.4	1.4	1.9	2.0	1.7	0.4	1.8
Lung FEV1/FVC ratio	1.2	6.1	9.9	3.1	2.3	2.3	-2.7	-1.7	1.9	2.9	3.0	1.3	3.1	1.9	2.7
Lung FVC	0.6	3.2	4.4	-2.0	-2.0	-2.0	2.0	1.4	-2.1	-1.4	-1.6	-1.6	-1.5	-1.8	-1.8
Neuroticism	1.8	4.4	6.9	-2.5	-2.6	-1.8	2.4	1.9	-2.0	-1.9	-2.3	-1.4	-2.1	-1.5	-2.1
Chronotype (morning person)	2.7	6.2	9.5	2.9	3.1	2.3	-2.6	-2.4	2.9	2.1	2.9	2.3	2.5	0.1	2.4
Hair Pigment	0.0	0.1	0.2	-0.3	-0.4	-0.3	0.2	0.3	0.2	-0.1	-0.4	0.4	-0.2	0.4	-0.0
Tanning	0.1	1.6	3.6	-0.9	-0.9	-1.5	1.0	-0.6	-0.7	-1.7	-1.3	-1.5	-1.4	-0.9	-1.9
Hand grip strength (left)	0.2	0.6	1.6	-0.2	-0.0	0.1	0.3	1.3	-0.5	1.1	1.0	0.5	1.0	-0.9	1.1
Number of treatments/medications taken	4.8	8.7	12.6	3.3	3.5	2.9	-3.5	-3.0	3.5	2.5	3.2	2.3	2.6	1.6	2.9
Average weekly spirits intake	1.0	1.2	4.1	0.9	1.2	0.8	-0.7	0.6	0.1	1.5	0.8	0.5	1.3	2.0	1.3
Sensitivity / hurt feelings	0.3	0.4	2.0	-0.2	-0.6	-0.6	0.2	-0.0	-0.9	-0.2	-0.6	-1.4	-0.3	0.9	-0.7
Frequency of depressed mood in last 2 weeks	3.0	4.3	6.5	-2.0	-2.5	-2.0	2.1	1.4	-2.4	-1.8	-2.5	-2.4	-2.0	-0.3	-2.3
Hearing difficulty/problems: Yes	0.1	0.2	0.9	0.3	-0.4	-0.4	-0.3	-0.1	-0.1	0.3	0.2	-0.6	0.1	1.0	0.2
Relative age of first facial hair	0.1	0.2	0.5	-0.3	0.1	-0.3	0.2	-0.6	-0.1	-0.6	-0.3	-0.5	-0.5	-0.7	-0.5
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	1.0	-0.4	-0.5	-1.0	0.6	0.2	-0.1	-0.5	-0.5	-0.0	-0.4	-0.8	-0.4
Ever used hormone-replacement therapy (HRT)	4.1	5.2	7.7	2.4	2.4	2.6	-2.3	-0.9	1.4	2.8	2.5	1.1	2.8	2.7	2.6
Ever had hysterectomy (womb removed)	0.4	0.4	0.8	0.7	0.8	0.6	-0.6	-0.5	0.0	0.9	0.7	-0.1	0.9	0.7	0.7
Systolic blood pressure, automated reading	1.5	4.5	8.9	2.0	2.1	2.0	-2.0	-0.8	0.8	2.9	3.0	0.5	2.9	1.3	2.8
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	1.3	0.4	0.5	0.4	-0.6	-0.5	0.5	0.8	1.1	0.2	0.8	-0.2	0.9
Angina	0.8	1.1	4.6	1.1	0.9	1.2	-0.9	-1.2	-0.1	0.5	0.6	-1.4	0.7	2.1	0.1
Medication for hormone replacement therapy	0.8	0.9	1.8	1.1	1.0	0.9	-1.1	-0.9	1.3	0.6	0.8	1.1	0.4	0.4	1.0
Vitamin and mineral supplements	2.3	3.1	5.0	2.1	2.2	2.1	-1.7	-0.7	0.5	2.2	2.1	0.2	2.1	1.5	2.1
Supplements: Zinc	1.1	1.2	2.9	-1.2	-1.7	-1.6	0.9	0.6	-0.7	-1.2	-1.2	-0.6	-1.3	-0.6	-1.1
Medication: Co-codamol	1.0	1.1	2.3	1.1	1.0	1.5	-1.1	-0.7	1.2	1.0	1.0	1.1	1.0	0.6	1.2
Medication: Metformin	3.7	5.2	6.9	2.3	2.4	2.5	-2.3	-1.8	2.6	2.1	2.6	2.4	2.4	0.5	2.5
Diabetes (father)	0.6	0.8	1.4	1.0	1.2	0.6	-1.2	-0.8	1.1	0.6	0.6	0.8	0.5	0.9	0.8
Diabetes (mother)	1.4	1.7	4.2	1.1	1.1	1.3	-0.9	0.1	0.1	2.0	1.9	0.3	1.9	0.5	2.0
Severe depression (siblings)	0.6	0.7	1.3	-0.5	-0.9	-1.1	0.8	0.3	-0.3	-1.1	-1.1	-0.3	-1.1	-0.2	-1.1
Pack years adult smoking proportion	2.4	3.6	7.2	2.1	1.9	1.2	-1.7	-0.5	1.0	2.6	2.1	1.1	2.7	2.1	2.3
Impedance of leg (right)	2.6	12.8	21.2	-4.0	-3.3	-3.2	3.8	1.9	-3.3	-4.1	-4.6	-3.2	-4.2	-1.5	-4.4
Leg fat-free mass (left)	3.6	18.8	27.2	5.2	4.5	3.9	-5.0	-3.6	3.8	4.6	5.2	2.5	4.9	3.3	4.6
Trunk fat percentage	6.8	27.4	41.8	6.2	5.5	4.8	-5.9	-3.8	3.7	6.0	6.5	2.0	6.2	4.5	5.8
Hand grip strength (right)	0.9	2.3	5.1	0.9	1.3	1.2	-0.9	0.5	1.1	1.9	2.0	2.2	1.9	-0.7	2.3
Townsend deprivation index at recruitment	0.3	0.4	0.9	0.6	0.3	0.4	-0.4	0.4	-0.1	1.0	0.6	0.2	1.0	0.8	0.7
Current tobacco smoking	0.1	0.1	0.3	0.2	-0.2	-0.5	0.0	0.4	-0.2	0.6	0.3	0.0	0.5	0.2	0.5
Average weekly fortified wine intake	0.4	0.5	1.2	-0.1	0.6	0.6	-0.1	-0.8	0.8	-1.1	-1.0	0.4	-1.0	0.4	-0.9
Maternal smoking around birth	12.9	18.6	26.8	5.2	4.7	3.6	-4.9	-3.1	4.1	4.5	4.7	3.2	4.7	3.6	4.7
Fed-up feelings	1.0	1.8	6.2	-0.7	-1.3	-1.6	0.9	-0.1	-1.5	-1.1	-1.3	-2.5	-1.2	0.5	-1.6
Frequency of unenthusiasm / disinterest in last 2 weeks	2.6	3.5	6.9	-1.7	-1.9	-1.6	1.7	0.7	-1.5	-2.3	-2.6	-1.7	-2.5	-0.3	-2.4
Relative age voice broke	0.6	0.9	7.7	-0.4	0.1	0.6	0.5	-0.8	0.6	-0.9	0.0	0.4	-0.6	-2.8	-0.5
Taking other prescription medications	1.6	2.5	3.3	1.6	1.8	1.8	-1.7	-1.1	1.3	1.7	1.8	0.9	1.8	1.3	1.8
Age when periods started (menarche)	0.8	2.0	5.2	-1.1	-0.7	-1.3	0.9	-0.3	-0.2	-2.3	-2.1	-0.6	-2.3	-0.5	-1.9
Bilateral oophorectomy (both ovaries removed)	0.2	0.3	0.6	0.7	0.5	0.2	-0.5	-0.0	0.2	0.8	0.4	0.4	0.8	0.6	0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	2.5	0.5	0.4	-0.2	-0.6	-1.6	1.3	-0.7	-0.1	0.6	-0.6	0.1	-0.3
Tinnitus: Yes, but not now, but have in the past	1.4	1.5	2.9	1.2	1.3	1.2	-1.0	0.2	0.6	1.7	1.4	1.1	1.5	0.9	1.7
Qualifications: CSEs or equivalent	2.3	3.0	5.6	2.0	1.3	1.8	-1.9	-0.4	1.2	2.2	2.2	1.3	2.0	1.1	2.4
Serious illness, injury or assault to yourself	1.7	2.0	3.3	1.6	1.8	0.8	-1.6	-1.4	1.5	1.4	1.8	1.0	1.6	0.3	1.5
High blood pressure	1.0	2.9	4.4	2.0	2.1	1.7	-1.9	-2.1	2.0	1.3	1.9	1.1	1.6	0.7	1.5
Hayfever, allergic rhinitis or eczema	7.2	15.7	24.6	-4.5	-5.0	-4.4	4.5	4.2	-3.5	-3.7	-4.5	-1.5	-4.2	-2.8	-3.7
Multivitamins +/- minerals	0.5	0.7	1.1	-1.0	-1.0	-1.0	0.5	0.4	0.5	-1.0	-0.9	1.0	-1.0	-0.7	-0.7
Stomach or abdominal pain in last month	0.6	0.8	3.5	0.7	0.4	-0.8	-0.7	-1.9	0.6	-0.9	-0.5	-0.8	-0.9	0.7	-0.8
Supplements: Glucosamine	1.6	2.1	3.9	1.4	1.9	1.6	-1.5	-1.6	2.0	0.8	1.5	1.6	1.0	-0.4	1.2
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.2	-0.5	-0.3	-0.5	0.4	0.4	-0.4	-0.3	-0.2	-0.3	-0.4	-0.3	-0.3
Medication: Atenolol	4.9	6.1	11.6	3.2	2.8	2.6	-3.1	-3.4	2.2	1.6	2.2	0.0	1.8	3.1	1.5
Medication: Levothyroxine sodium	0.2	0.3	0.5	-0.6	-0.7	-0.7	0.3	0.2	-0.3	-0.4	-0.6	-0.5	-0.7	0.3	-0.4
Sitting height	0.6	4.0	6.6	-2.0	-2.0	-2.6	1.8	0.0	-1.1	-2.6	-2.2	-1.5	-2.4	-1.7	-2.5
Chronic bronchitis/emphysema (father)	0.6	0.7	1.6	0.9	0.7	0.7	-0.5	-0.6	-0.4	0.9	0.9	-1.3	0.9	1.0	0.5
High blood pressure (mother)	7.0	9.8	14.1	3.4	3.7	3.3	-3.3	-2.1	2.1	3.6	3.7	1.1	3.8	2.7	3.5
Body mass index (BMI)	11.2	47.6	70.9	7.9	7.2	6.6	-7.5	-4.3	5.3	8.0	8.4	4.1	8.2	5.2	7.9
Impedance of leg (left)	2.9	14.0	21.8	-4.2	-3.6	-3.4	4.0	2.3	-3.5	-4.2	-4.7	-3.2	-4.3	-1.8	-4.5
Leg predicted mass (left)	3.6	19.0	27.4	5.2	4.5	3.9	-5.1	-3.6	3.9	4.6	5.2	2.6	4.9	3.3	4.7
Trunk fat mass	7.2	31.1	46.5	6.6	5.9	5.2	-6.3	-4.2	4.0	6.3	6.8	2.2	6.6	4.8	6.1
Waist circumference	12.6	46.3	67.4	7.9	7.3	6.6	-7.7	-5.1	5.4	7.5	8.2	3.5	7.9	5.2	7.5
Number of incorrect matches in round	2.6	4.3	12.5	1.8	1.9	1.8	-1.7	-0.7	-0.8	2.7	2.2	-1.8	2.6	3.5	1.7
Past tobacco smoking	2.6	4.9	8.1	-2.4	-2.2	-1.9	2.7	2.8	-2.6	-1.8	-2.7	-1.4	-2.1	-0.6	-2.1
Alcohol usually taken with meals	0.6	1.0	1.6	-1.3	-1.1	-1.1	0.9	0.4	-0.5	-1.2	-1.0	-0.4	-1.2	-0.9	-1.2
Nervous feelings	1.5	2.7	4.5	-1.9	-1.6	-1.7	1.7	1.0	-2.0	-1.5	-1.8	-2.1	-1.5	-0.3	-1.9
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.2	3.0	-1.0	-1.7	-1.5	1.2	1.3	-1.0	-0.6	-1.2	-0.5	-0.8	-0.2	-0.8
Hearing difficulty/problems with background noise	1.0	1.6	3.1	1.8	1.2	1.0	-1.6	-1.5	1.0	1.2	1.5	0.3	1.3	1.3	1.1
Hair/balding pattern: Pattern 2	0.3	0.4	2.0	0.4	0.6	0.3	-0.4	-0.0	-0.5	0.8	0.3	-0.8	0.8	1.4	0.3
Had menopause	0.3	0.3	1.0	-0.8	-0.9	-0.2	0.8	1.0	-0.6	-0.2	-0.2	-0.0	-0.2	-0.7	-0.3
Had other major operations	0.9	1.1	2.0	1.3	0.9	0.9	-1.1	-0.9	1.1	1.1	1.4	0.8	1.1	0.5	1.1
Forced vital capacity (FVC)	1.7	6.7	9.3	-3.0	-2.8	-2.9	2.6	1.0	-2.2	-2.8	-2.7	-2.2	-2.8	-2.3	-3.0
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	0.6	-0.5	-0.4	-0.7	0.4	-0.4	0.1	-0.8	-0.5	-0.3	-0.8	-0.3	-0.6
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.6	1.1	1.3	0.5	-0.9	-1.3	0.9	0.1	0.2	0.2	0.3	0.8	0.1
Qualifications: None of the above	6.6	14.1	21.4	4.4	4.1	3.6	-3.9	-2.2	2.4	4.5	4.4	1.5	4.6	3.7	4.1
Financial difficulties in last 2 years	0.7	0.9	2.8	0.8	0.3	0.7	-0.5	0.6	-0.1	1.7	1.2	0.3	1.5	0.8	1.4
Mouth/teeth dental problems	0.1	0.2	1.0	-0.1	-0.2	-0.2	0.1	0.4	0.5	-0.4	-0.4	1.0	-0.5	-0.2	-0.1
Heart attack	1.1	1.4	2.3	1.4	1.3	1.3	-1.2	-0.8	1.5	0.8	1.2	1.4	0.9	0.6	1.1
Allergy	3.7	8.6	13.3	3.4	3.6	3.0	-3.1	-2.7	2.2	3.0	3.6	0.8	3.4	2.0	2.9
Pain all over the body in last month	0.2	0.2	1.1	0.1	-0.2	-0.3	0.2	0.7	0.3	0.1	-0.1	1.1	0.1	-0.6	0.3
Diabetes (self-reported)	1.8	2.7	4.4	1.7	1.7	1.7	-1.9	-1.7	2.1	1.3	1.8	1.7	1.5	0.4	1.7
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	4.1	-0.1	-0.7	-0.2	0.2	1.3	0.6	-0.4	-0.7	2.0	-0.7	-0.7	0.3
Medication: Ramipril	0.4	0.6	1.6	0.8	1.2	0.9	-0.6	-0.1	0.5	0.7	0.3	0.6	0.7	1.1	0.8
Medication: Simvastatin	2.8	4.1	7.3	2.3	2.7	2.2	-2.3	-2.3	2.5	1.4	2.0	1.6	1.6	0.8	1.9
Fluid intelligence score	9.0	18.6	27.1	-5.0	-4.6	-4.4	4.6	2.4	-3.5	-4.9	-5.2	-3.1	-5.1	-2.7	-5.0
Illnesses of siblings	3.7	5.2	11.2	-2.3	-1.9	-1.7	2.1	0.9	0.0	-3.2	-2.6	0.9	-3.1	-3.4	-2.5
Neuroticism score	2.3	4.8	7.5	-2.4	-2.7	-2.2	2.3	1.2	-2.5	-2.0	-2.4	-2.5	-2.1	-0.8	-2.4
Weight	6.7	33.0	47.6	6.8	6.1	5.3	-6.6	-4.4	4.7	6.3	6.9	3.1	6.7	4.5	6.2
Impedance of arm (right)	2.8	13.0	22.1	-3.9	-3.6	-3.3	3.6	1.5	-2.2	-4.6	-4.7	-2.2	-4.7	-2.6	-4.5
Arm fat percentage (right)	9.7	38.2	54.6	7.3	6.5	6.1	-6.9	-4.5	5.0	6.8	7.4	3.4	7.1	4.7	6.8
Trunk fat-free mass	0.9	5.5	8.4	2.8	2.5	2.0	-2.9	-2.3	2.3	2.2	2.5	1.5	2.4	1.9	2.2
Hip circumference	4.9	21.1	33.9	5.2	4.8	4.1	-5.1	-3.3	3.6	5.3	5.8	2.5	5.6	3.2	5.2
Time employed in main current job	0.7	0.8	3.3	-1.1	-1.2	-0.4	1.2	1.8	-0.6	-0.2	-0.6	0.6	-0.4	-0.8	-0.1
Alcohol intake versus 10 years previously	0.8	1.2	2.9	0.2	0.5	0.9	-0.4	0.5	0.9	1.2	1.4	1.7	1.2	-1.2	1.6
Father’s age at death	3.8	5.1	8.1	-2.6	-2.2	-2.5	2.4	1.1	-1.1	-2.8	-2.4	-0.8	-2.8	-2.4	-2.6
Worrier / anxious feelings	0.6	1.2	2.5	-1.1	-1.6	-1.4	1.1	0.7	-1.2	-0.9	-0.9	-1.2	-1.0	-0.6	-0.9
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.4	3.3	-0.6	-0.8	-0.5	0.6	-0.8	-0.7	-1.7	-1.4	-1.8	-1.8	-0.1	-1.7
Falls in the last year	0.3	0.4	1.7	-0.3	-0.8	-0.1	0.7	1.3	-0.7	0.6	0.2	0.1	0.4	-0.5	0.4
Hair/balding pattern: Pattern 3	0.2	0.3	1.3	-0.4	-0.7	-0.1	0.2	0.3	-1.0	0.4	0.2	-1.1	0.2	0.2	0.0
Number of live births	0.1	0.1	0.5	-0.0	-0.6	-0.6	-0.0	-0.4	0.1	-0.2	0.2	-0.3	-0.1	-0.7	-0.2
Forced expiratory volume in 1-second (FEV1)	1.0	3.5	5.2	-2.1	-2.1	-2.2	1.8	0.6	-1.4	-2.0	-1.7	-1.3	-2.0	-2.3	-2.1
Pulse rate	0.2	0.3	0.6	0.5	0.8	0.4	-0.6	-0.8	0.3	0.4	0.7	-0.2	0.4	0.3	0.5
Happiness	2.4	3.0	4.0	-2.0	-2.0	-1.9	1.8	1.6	-2.0	-1.4	-2.0	-1.6	-1.7	-0.3	-1.7
Noisy workplace	6.9	8.5	13.6	3.2	2.7	2.8	-3.0	-1.6	2.5	3.4	3.7	2.4	3.6	1.2	3.6
Qualifications: A levels/AS levels or equivalent	3.3	7.4	14.5	-3.0	-2.3	-2.3	2.7	0.9	-1.1	-3.8	-3.7	-0.7	-3.6	-2.4	-3.5
Serious illness, injury or assault of a close relative in last 2 years	3.7	4.2	8.1	-2.2	-1.9	-2.4	2.0	0.8	-1.3	-2.6	-2.6	-1.1	-2.8	-1.4	-2.4
Mouth/teeth dental problems: Dentures	2.8	4.7	7.5	2.3	2.3	2.7	-2.3	-1.4	2.4	2.1	2.2	2.2	2.2	1.0	2.4
Asthma	3.3	6.6	12.7	-2.8	-2.5	-2.4	2.6	1.4	-1.1	-3.2	-3.6	-0.3	-3.5	-2.2	-2.9
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.3	2.0	0.0	-0.3	-0.9	-0.2	0.7	-0.2	0.4	-0.4	0.2	0.0	1.4	0.4
Medication: Cholesterol lowering	4.2	6.6	12.5	3.0	3.3	2.6	-3.0	-3.5	3.2	1.5	2.8	1.3	1.9	1.0	2.0
Depression (self-reported)	0.5	0.7	1.8	-0.4	-0.3	0.2	0.4	-0.3	-0.4	-1.2	-1.4	-0.8	-1.3	0.4	-1.3
Medication: Lansoprazole	5.5	6.3	9.9	2.9	3.0	2.4	-2.9	-3.2	3.0	1.9	3.0	1.5	2.4	0.6	2.2
Prospective memory result	0.8	1.0	3.4	1.1	0.8	0.5	-0.7	0.4	-0.0	1.4	0.9	0.1	1.3	1.9	1.1
Lung cancer (father)	0.9	1.1	2.2	1.5	1.2	0.9	-1.3	-1.3	1.4	0.3	0.6	0.8	0.3	1.2	0.7
Illnesses of mother	10.0	12.4	22.5	-3.8	-3.6	-3.5	3.3	1.1	-1.6	-4.7	-4.3	-1.3	-4.7	-3.2	-4.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.9	2.4	-1.1	-0.9	-1.0	0.8	-0.2	-0.7	-1.1	-0.6	-0.9	-1.0	-1.6	-1.2
Pulse wave Arterial Stiffness index	0.3	0.4	0.9	0.6	0.4	0.2	-0.7	-0.8	0.2	0.7	0.7	-0.4	0.7	1.0	0.5
Impedance of arm (left)	3.1	14.6	23.6	-4.1	-3.9	-3.9	3.8	1.5	-2.5	-4.8	-4.8	-2.6	-4.9	-2.5	-4.7
Arm fat mass (right)	9.9	40.7	59.6	7.5	6.7	6.1	-7.1	-4.4	5.0	7.2	7.7	3.4	7.5	5.0	7.2
Trunk predicted mass	1.0	5.9	9.1	2.9	2.6	2.1	-3.0	-2.4	2.4	2.2	2.6	1.6	2.5	2.0	2.3
Standing height	0.4	4.4	9.2	-1.9	-1.8	-2.2	1.5	-0.7	-0.9	-3.0	-2.6	-1.9	-2.8	-1.1	-3.0
Length of working week for main job	0.5	0.6	3.0	0.1	-0.5	-0.1	0.0	0.4	-1.2	0.5	-0.2	-1.4	0.2	1.7	-0.0
Exposure to tobacco smoke at home	0.4	0.5	2.2	-0.2	-0.5	-0.1	0.4	0.5	-1.3	0.6	0.3	-1.5	0.6	-0.0	0.0
Breastfed as a baby	0.5	0.6	3.1	0.3	0.8	0.4	-0.6	-1.8	0.9	-0.9	-0.4	-0.2	-0.8	0.1	-0.6
Tense / ‘highly strung’	5.8	9.6	17.6	-3.3	-3.5	-3.2	3.3	2.3	-4.2	-2.3	-3.2	-4.0	-2.5	-0.7	-3.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.4	3.4	-1.0	-0.9	-1.2	1.1	-0.1	-1.2	-1.2	-1.3	-1.9	-1.1	-0.1	-1.5
Hair/balding pattern: Pattern 4	0.3	0.6	1.8	-0.0	-0.5	-0.6	0.4	-0.6	0.0	-1.4	-1.1	-0.6	-1.2	0.0	-1.2
Birth weight of first child	0.1	0.2	0.6	-0.2	0.2	0.2	0.1	-0.2	0.7	-0.4	-0.2	0.8	-0.5	-0.8	0.0
Peak expiratory flow (PEF)	0.8	1.9	7.3	-1.4	-1.3	-1.6	1.1	-0.2	-0.2	-1.7	-1.0	-0.2	-1.6	-2.7	-1.4
Pulse wave reflection index	0.0	0.0	0.2	-0.3	-0.3	0.1	0.1	0.4	-0.1	0.3	-0.1	0.2	0.2	0.2	0.2
Ever highly irritable/argumentative for 2 days	0.7	0.8	1.7	0.7	1.1	0.4	-0.5	0.1	0.3	1.2	1.3	0.8	1.3	-0.5	1.3
Loud music exposure frequency	0.2	0.2	0.8	-0.3	-0.8	-0.9	0.3	-0.2	-0.1	-0.3	-0.1	-0.2	-0.1	-0.7	-0.4
Qualifications: O levels/GCSEs or equivalent	5.6	8.9	15.3	-3.4	-3.4	-2.2	3.0	1.9	-1.8	-3.7	-3.9	-0.8	-3.9	-2.5	-3.5
Mouth/teeth dental problems: Bleeding gums	3.5	4.5	7.2	-2.3	-2.6	-2.7	2.4	1.6	-2.2	-1.9	-1.9	-1.8	-2.0	-1.9	-2.0
Blood clot in the leg (DVT)	2.3	3.0	4.3	1.8	1.5	2.1	-2.0	-0.9	1.9	1.6	1.6	2.0	1.7	1.7	1.7
Medication: Paracetamol	4.8	7.9	11.2	3.3	3.1	3.1	-3.3	-2.4	2.5	2.8	3.1	1.4	2.7	2.4	3.0
Headache pain in last month	0.5	0.8	1.4	1.1	0.7	0.1	-1.1	-0.6	0.9	1.1	1.1	0.8	0.9	0.4	1.2
Medication for cholesterol, blood pressure or diabetes	3.6	6.0	8.8	-2.7	-3.0	-2.7	2.8	2.9	-2.5	-2.1	-2.9	-1.0	-2.4	-1.4	-2.2
Glaucoma (self-reported)	0.6	0.8	2.3	0.9	1.0	0.6	-1.1	-1.5	1.5	0.1	0.5	0.7	0.2	0.4	0.4
Gout (self-reported)	0.5	0.7	1.8	-0.7	-1.1	-1.0	0.5	-0.4	-0.1	-0.9	-0.5	-0.4	-0.9	-1.4	-0.9
Hypothyroidism/myxoedema (self-reported)	1.1	2.2	4.3	-1.6	-1.8	-1.6	1.4	0.5	-0.6	-1.9	-1.8	-0.6	-2.1	-1.3	-1.6
Medication: Amlodipine	2.0	2.9	5.4	2.0	1.3	0.9	-1.7	-0.7	1.2	2.3	2.2	1.1	2.3	1.1	2.3
Medication: Ventolin 100micrograms inhaler	0.6	0.8	4.9	0.0	0.0	-0.0	-0.1	0.1	1.5	-0.2	0.1	2.2	-0.0	-1.5	0.4
Birth weight	0.6	1.3	2.6	1.1	1.6	1.5	-1.1	-0.8	0.8	1.2	1.3	0.6	1.3	0.5	1.1
Chronic bronchitis/emphysema (mother)	1.4	1.6	5.7	1.3	1.0	1.2	-1.0	-0.7	-0.4	1.4	1.0	-1.3	1.5	2.4	0.8
High blood pressure (siblings)	1.2	1.7	5.6	0.8	0.7	0.3	-0.7	-0.1	-1.2	1.8	1.2	-1.9	1.7	2.4	0.9
Forced vital capacity (FVC), Best measure	0.9	3.5	5.4	-2.2	-1.7	-1.9	1.8	0.4	-1.7	-2.1	-1.9	-1.9	-2.1	-1.7	-2.3
Body fat percentage	8.2	32.2	49.3	6.6	6.0	5.4	-6.3	-4.0	4.1	6.5	7.0	2.4	6.8	4.6	6.3
Leg fat percentage (right)	9.1	33.0	49.7	6.6	6.1	5.8	-6.2	-3.8	4.0	6.7	7.0	2.5	7.0	4.6	6.4
Arm fat-free mass (right)	2.5	12.8	18.6	4.3	3.7	3.0	-4.2	-2.8	2.9	3.9	4.3	1.9	4.2	3.0	3.8
Exposure to tobacco smoke outside home	0.6	0.8	2.9	-0.4	-1.0	-0.6	0.7	0.4	-1.3	-0.5	-1.0	-1.7	-0.7	0.7	-0.9
Comparative body size at age 10	8.0	22.1	40.0	4.9	4.6	4.5	-4.6	-1.4	2.5	6.3	5.7	2.6	6.3	4.1	5.8
Number of full brothers	0.2	0.2	1.3	0.4	0.1	0.6	-0.3	-0.1	0.8	0.0	0.2	1.2	0.1	-0.3	0.3
Worry too long after embarrassment	1.3	2.1	4.6	-1.4	-1.5	-1.4	1.4	0.8	-2.0	-1.2	-1.5	-2.1	-1.4	-0.1	-1.6
Seen a psychiatrist for nerves, anxiety, tension or depression	1.3	1.7	5.2	-1.2	-1.2	-1.6	1.1	-0.3	-1.4	-1.2	-1.1	-2.3	-1.1	-0.7	-1.6
Wheeze or whistling in the chest in last year	0.2	0.3	0.8	-0.4	-0.8	-0.9	0.6	0.9	-0.8	-0.1	-0.4	-0.4	-0.3	-0.2	-0.2
Number of children fathered	1.5	1.7	4.8	0.9	0.9	1.2	-0.8	0.6	0.1	2.2	1.6	0.7	2.2	0.8	1.8
Reason for reducing amount of alcohol drunk: Health precaution	3.6	4.2	7.7	-2.6	-2.8	-2.0	2.5	2.1	-1.9	-1.7	-2.1	-0.8	-1.9	-1.6	-1.8
Age at first live birth	1.2	2.1	3.9	-1.8	-1.3	-1.1	1.4	0.3	-0.6	-2.0	-1.7	-0.6	-2.0	-1.6	-1.7
Pulse wave peak to peak time	0.6	0.7	1.3	-0.8	-0.7	-0.5	1.0	0.9	-0.5	-1.1	-1.0	0.2	-1.0	-1.1	-0.9
Health satisfaction	1.9	2.4	5.2	1.9	2.3	2.0	-1.8	-1.3	1.4	1.1	1.2	0.8	1.0	1.6	1.4
Shortness of breath walking on level ground	0.5	0.6	3.2	0.4	0.4	0.3	-0.4	-1.2	-0.4	-0.0	0.3	-1.8	0.1	0.9	-0.5
Qualifications: College or University degree	4.0	12.5	22.0	-3.7	-3.5	-3.5	3.6	1.4	-1.6	-4.6	-4.4	-1.0	-4.7	-3.8	-4.1
Eye problems/disorders: None of the above	1.0	1.2	2.5	-1.0	-1.1	-0.4	1.1	0.4	-0.5	-1.6	-1.5	-0.3	-1.4	-1.1	-1.5
Mouth/teeth dental problems: Loose teeth	0.4	0.5	2.9	-0.4	-0.5	-0.9	0.2	-0.4	-1.0	0.1	0.3	-1.7	0.5	0.5	-0.4
Emphysema/chronic bronchitis	0.4	0.4	1.5	0.2	0.0	0.7	-0.2	0.4	0.1	1.0	0.8	0.5	1.2	-0.3	0.8
Medication for pain relief, constipation, heartburn	3.1	5.2	8.3	-2.8	-2.5	-2.2	2.9	2.8	-2.2	-1.9	-2.5	-0.7	-1.9	-2.1	-2.1
Neck or shoulder pain in last month	3.4	4.9	7.0	2.6	2.4	2.6	-2.3	-1.5	1.9	2.3	2.5	1.5	2.4	1.4	2.5
Medication: Blood pressure	1.5	2.6	4.0	1.6	1.9	2.0	-1.7	-1.8	0.8	1.7	1.8	-0.4	1.8	1.8	1.4
Angina (self-reported)	0.9	1.2	4.5	1.3	1.1	1.3	-1.1	-1.3	0.2	0.7	0.8	-0.9	0.9	2.1	0.4
Migraine (self-reported)	3.6	4.5	7.1	2.4	2.4	2.4	-2.3	-1.1	2.5	1.8	1.8	2.7	1.7	1.8	2.2
Medication: Ibuprofen	0.3	0.3	1.4	0.3	0.1	-0.5	-0.4	0.7	0.1	0.6	-0.1	0.8	0.2	1.2	0.7
Medication: Allopurinol	0.2	0.2	1.6	-0.2	-0.5	-0.3	-0.1	-0.3	0.2	0.2	0.6	0.3	0.3	-1.2	0.3
Medication: Omeprazole	1.7	2.1	3.7	1.4	1.6	1.9	-1.2	-0.0	0.7	1.8	1.5	1.0	1.7	1.4	1.8
Medication: Seretide 50 evohaler	0.2	0.3	0.9	-0.2	-0.3	-0.2	0.2	0.3	-0.7	-0.1	-0.6	-0.9	-0.3	1.0	-0.4
Mean time to correctly identify matches	0.1	0.3	1.0	-0.6	-0.5	0.3	0.6	0.9	-0.4	-0.3	-0.2	0.3	-0.2	-1.0	-0.2
Heart disease (mother)	0.7	0.9	2.5	0.8	0.7	0.6	-0.5	0.3	-0.2	1.6	1.4	0.0	1.4	0.6	1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.5	-0.3	-0.2	-0.4	0.3	0.7	-0.6	0.4	0.1	-0.2	0.3	-0.1	0.3
Whole body fat mass	9.1	38.2	57.2	7.2	6.5	5.9	-6.9	-4.4	4.4	7.1	7.6	2.7	7.4	5.2	6.8
Leg fat mass (right)	11.3	43.8	66.0	7.6	7.0	6.5	-7.2	-4.4	4.7	7.7	8.1	3.2	8.0	5.3	7.4
Arm predicted mass (right)	2.7	13.7	20.2	4.4	3.9	3.2	-4.3	-2.9	3.0	4.1	4.5	2.0	4.3	3.0	4.0
Pulse rate, automated reading	0.8	2.4	3.9	1.9	1.9	0.8	-1.9	-2.0	1.4	1.4	1.8	0.3	1.6	1.5	1.5
Alcohol intake frequency.	0.2	0.5	1.6	0.2	-0.6	-1.0	0.2	1.2	-1.1	0.9	0.2	-0.6	0.7	0.5	0.4
Comparative height size at age 10	0.1	0.4	2.5	0.3	0.0	-0.2	-0.4	-0.5	-0.5	0.3	0.1	-1.1	0.2	1.6	-0.2
Number of full sisters	0.5	0.6	2.0	0.1	-0.3	-0.7	0.1	0.3	-1.3	0.7	0.2	-1.4	0.8	1.2	0.1
Suffer from ‘nerves’	3.2	5.0	8.0	-2.5	-2.3	-2.0	2.3	0.9	-1.8	-2.7	-2.8	-1.6	-2.5	-1.6	-2.8
Overall health rating	1.5	3.3	4.9	2.2	1.9	1.9	-2.1	-1.6	1.2	1.9	2.0	0.4	1.9	1.9	1.8
Chest pain or discomfort	1.1	1.6	4.2	-0.9	-0.9	-1.2	0.8	-0.3	-0.0	-2.0	-1.7	-0.5	-2.0	-0.7	-1.7
Had major operations	0.6	0.7	3.1	0.5	0.5	0.8	-0.4	0.3	1.1	0.8	0.7	1.8	0.9	-0.2	1.2
Age at last live birth	2.0	2.9	4.8	-2.2	-1.8	-1.3	2.0	1.3	-1.6	-1.7	-1.8	-1.3	-1.7	-1.6	-1.9
Family relationship satisfaction	4.0	4.9	6.7	-2.5	-2.3	-2.2	2.6	2.0	-2.3	-2.2	-2.6	-1.6	-2.2	-1.4	-2.4
Leg pain on walking	0.3	0.4	1.8	0.1	0.1	0.1	-0.0	-1.0	-0.4	-0.6	-0.4	-1.3	-0.5	0.1	-0.8
Qualifications: NVQ or HND or HNC or equivalent	1.2	1.4	2.7	1.5	0.9	0.7	-1.3	-0.2	0.7	1.6	1.4	0.8	1.4	1.3	1.6
Commuting to job workplace: Car/motor vehicle	0.6	0.6	3.2	-0.5	-0.8	-0.8	0.8	1.8	-1.0	0.5	0.1	0.4	0.5	-0.8	0.3
Illness, injury, bereavement, stress in last 2 years	0.7	0.9	2.3	1.1	1.2	1.4	-1.1	-1.5	0.6	0.5	0.8	-0.2	0.7	0.7	0.4
Medication: Aspirin	2.4	3.1	5.8	2.2	2.1	1.8	-2.0	-2.4	2.2	1.0	2.0	1.1	1.3	0.3	1.4
Supplements: Vitamin C	3.0	3.6	10.0	-2.3	-2.4	-1.3	2.3	1.6	-0.6	-1.9	-1.7	0.5	-1.6	-3.2	-1.6
Knee pain experienced in last month	1.5	2.4	5.4	1.6	1.2	1.2	-1.4	-0.5	-0.1	2.3	2.1	-0.7	2.2	1.7	1.8
Hypertension (Self-reported)	1.4	3.9	5.6	2.3	2.4	2.1	-2.2	-2.2	2.2	1.6	2.1	1.3	1.9	1.1	1.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	0.8	-0.6	-0.7	-0.3	0.4	-0.0	-0.4	-0.7	-0.5	-0.6	-0.9	-0.4	-0.6
Illnesses of father: Heart disease	0.4	0.5	1.5	0.9	1.1	0.5	-1.0	-0.7	0.4	0.5	0.5	-0.0	0.3	1.2	0.5
Illnesses of siblings: Diabetes	0.3	0.3	0.9	0.4	0.2	-0.1	-0.3	0.1	-0.3	1.0	0.9	-0.4	1.0	0.3	0.7
Smoking status: Previous	4.5	6.8	10.6	2.9	2.8	2.6	-3.2	-3.2	2.8	2.2	3.0	1.4	2.4	1.5	2.4
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.1	2.0	-1.0	-0.8	-1.3	0.7	-0.4	-0.6	-1.4	-1.2	-1.1	-1.4	-0.9	-1.4
Whole body fat-free mass	2.0	11.6	16.7	4.1	3.6	3.0	-4.1	-3.0	3.2	3.4	4.0	2.2	3.7	2.6	3.5
Leg fat-free mass (right)	3.0	15.9	23.2	4.7	4.1	3.5	-4.7	-3.3	3.6	4.2	4.8	2.5	4.4	2.9	4.3
Arm fat percentage (left)	8.9	35.5	51.4	7.1	6.2	5.7	-6.7	-4.4	4.8	6.6	7.2	3.1	6.8	4.7	6.6
Average weekly red wine intake	0.1	0.2	0.7	0.5	0.4	0.3	-0.5	-0.5	0.3	0.2	0.1	-0.0	0.3	0.9	0.1
Handedness (chirality/laterality): Left-handed	0.8	0.9	2.0	1.1	0.5	0.4	-1.2	-0.6	1.0	1.1	1.4	0.9	1.1	0.2	1.2
Mood swings	1.0	1.8	2.8	-1.2	-1.7	-1.5	1.2	0.5	-1.4	-1.3	-1.5	-1.5	-1.4	-0.6	-1.5
Loneliness, isolation	0.5	0.7	1.6	-0.8	-1.2	-1.3	0.9	1.3	-0.6	-0.5	-1.0	0.3	-0.7	-0.5	-0.5
Long-standing illness, disability or infirmity	0.9	1.4	3.5	-1.0	-1.2	-1.4	0.9	0.4	-1.5	-0.8	-1.3	-1.9	-0.8	0.4	-1.3
Ever had bowel cancer screening	1.4	1.6	3.2	-1.4	-1.6	-0.7	1.3	1.1	-0.9	-1.4	-1.7	-0.6	-1.8	-0.5	-1.3
Diabetes diagnosed by doctor	1.7	2.9	4.3	1.8	1.8	1.8	-1.8	-1.6	1.7	1.6	2.1	1.3	1.8	0.6	1.8
Ever had stillbirth, spontaneous miscarriage or termination	2.3	2.4	4.8	-1.7	-1.6	-1.5	1.4	0.4	-0.3	-2.0	-1.7	-0.1	-2.0	-2.2	-1.7
Friendships satisfaction	3.7	4.6	6.4	-2.5	-2.1	-2.2	2.4	1.5	-2.5	-2.0	-2.2	-2.3	-2.1	-1.2	-2.3
Qualifications: nursing, teaching	0.6	1.0	2.9	-0.8	-0.4	-0.6	0.4	-0.1	0.7	-1.4	-0.9	1.1	-1.4	-1.7	-0.8
Commuting to job workplace: Walk	0.9	0.9	2.3	-0.6	-0.6	-1.5	0.5	-0.6	0.0	-1.4	-0.9	-0.5	-1.5	-1.3	-1.0
Eye problems/disorders: Cataract	0.9	1.0	2.6	1.1	1.1	1.1	-1.0	-0.5	0.6	1.1	1.0	0.3	1.0	1.6	1.0
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	2.3	-1.1	-1.1	-1.3	1.1	0.0	-1.0	-1.4	-1.1	-1.3	-1.2	-1.1	-1.5
Medication for cholesterol	3.3	5.0	7.3	-2.5	-2.2	-1.9	2.5	1.7	-2.7	-2.0	-2.4	-2.4	-2.1	-1.3	-2.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.0	2.3	1.3	0.7	0.9	-1.2	-1.1	1.5	0.6	1.0	1.2	0.8	0.3	0.8
Back pain experienced in last month	0.5	0.7	1.9	1.0	0.9	0.4	-1.0	-1.4	0.5	0.6	0.8	-0.6	0.6	1.3	0.5
Mineral and other dietary supplements	0.4	0.5	1.8	-0.5	-0.9	-0.5	0.7	0.9	-1.3	0.1	-0.4	-1.1	-0.2	0.1	-0.2
Breast cancer (self-reported)	2.7	3.3	6.2	2.1	2.2	1.9	-2.2	-2.5	1.3	1.6	2.0	-0.3	1.7	1.5	1.4
Asthma (self-reported)	3.4	6.8	13.2	-2.9	-2.5	-2.4	2.7	1.6	-1.1	-3.3	-3.6	-0.2	-3.5	-2.3	-2.9
Osteoporosis (self-reported)	0.6	0.7	2.2	0.5	0.6	1.4	-0.7	-0.3	-0.1	0.9	0.8	-0.6	0.8	1.5	0.6
Osteoarthritis (self-reported)	0.5	0.6	1.0	1.0	1.0	1.0	-0.9	-0.4	0.8	0.7	0.6	0.8	0.6	0.6	0.8
Medication: Aspirin	2.0	2.6	4.7	1.9	1.9	1.8	-1.8	-2.2	1.9	0.9	1.9	1.0	1.2	0.1	1.3
Medication: Gliclazide	0.3	0.3	0.9	0.3	0.5	0.7	-0.3	-0.9	0.9	-0.1	0.4	0.7	0.1	-0.8	0.3
Illnesses of father: None of the above (group 1)	0.6	0.7	1.6	0.9	0.3	0.3	-0.7	-0.2	0.8	1.1	1.1	1.1	1.3	0.3	1.2
Smoking status: Current	0.1	0.2	0.8	-0.4	-0.6	-0.9	0.5	0.5	-0.4	-0.1	-0.2	-0.3	-0.1	-0.3	-0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	2.1	1.0	1.2	1.4	-0.7	-0.1	-0.4	1.5	1.2	-0.6	1.4	1.1	1.0
Whole body water mass	2.1	11.8	17.1	4.1	3.7	3.0	-4.1	-3.1	3.2	3.5	4.0	2.1	3.8	2.7	3.5
Leg predicted mass (right)	3.0	15.9	23.0	4.7	4.1	3.5	-4.7	-3.2	3.6	4.2	4.8	2.5	4.5	3.0	4.3
Arm fat mass (left)	10.0	41.0	59.1	7.6	6.8	6.1	-7.2	-4.6	5.2	7.1	7.7	3.6	7.4	5.0	7.1
Number of self-reported non-cancer illnesses	0.5	0.9	1.6	1.1	1.0	1.3	-1.1	-1.1	0.8	1.0	1.1	0.1	1.0	0.8	0.9
Average weekly champagne plus white wine intake	0.9	1.2	2.8	-1.1	-1.1	-1.7	0.6	-0.3	-0.5	-1.4	-1.1	-1.0	-1.5	-0.5	-1.4
Miserableness	1.4	2.3	3.7	-1.4	-1.7	-1.5	1.6	0.2	-1.4	-1.7	-1.6	-1.9	-1.7	-1.1	-1.9
Guilty feelings	1.1	1.7	2.6	-1.3	-1.6	-1.6	1.4	0.6	-1.1	-1.3	-1.3	-1.0	-1.2	-1.3	-1.5
Wears glasses or contact lenses	0.7	0.8	1.6	1.0	0.7	0.7	-0.9	-0.8	0.2	1.0	1.3	-0.5	1.1	1.0	0.7
Ever taken oral contraceptive pill	1.4	1.6	4.7	-1.1	-0.8	-0.4	0.8	-0.5	0.0	-2.1	-1.9	-0.4	-2.2	-0.5	-1.9
Hearing aid user	0.8	0.9	3.6	-1.3	-1.1	-0.4	1.2	1.9	-1.1	0.0	-0.6	0.0	-0.1	-0.8	-0.1
Mother’s age at death	5.1	6.4	9.8	-2.8	-2.5	-2.4	2.8	1.8	-1.7	-3.0	-3.1	-0.8	-3.1	-2.4	-2.9
Financial situation satisfaction	0.9	1.1	1.9	1.0	1.2	1.1	-1.1	-1.0	0.4	1.1	1.2	-0.5	1.1	1.4	0.9
Tinnitus: Yes, now most or all of the time	1.1	1.3	6.7	0.5	0.4	-0.2	-0.4	0.0	-1.2	1.1	0.4	-1.9	1.1	2.6	0.3
Commuting to job workplace: Public transport	3.1	3.7	6.2	-2.2	-2.1	-2.2	2.0	1.0	-0.9	-2.3	-2.0	-0.3	-2.2	-2.5	-2.0
Eye problems/disorders: Glaucoma	0.6	0.7	1.8	0.9	1.0	0.5	-0.9	-1.0	1.3	0.4	0.7	1.0	0.5	0.3	0.7
Medication: Blood pressure	2.8	5.3	7.3	2.6	2.7	2.1	-2.6	-2.0	2.6	2.0	2.5	2.1	2.2	1.2	2.5
Pain type(s) experienced in last month: Hip pain	2.1	2.7	3.7	1.9	1.9	1.5	-1.8	-1.2	1.7	1.6	1.8	1.4	1.5	1.3	1.9
Supplements: Fish oil (including cod liver oil)	0.3	0.4	1.6	0.1	0.5	0.4	-0.2	-0.4	1.0	-0.2	0.3	1.2	0.1	-0.9	0.1
High cholesterol (Self-reported)	3.0	5.3	8.6	2.7	2.9	2.4	-2.6	-2.9	2.8	1.6	2.4	1.4	1.9	0.9	1.9
Medication: Bendroflumethiazide	0.8	1.2	2.6	1.4	1.2	0.3	-1.3	-1.6	1.2	0.9	1.1	0.3	1.0	1.1	0.9
Medication: Paracetamol	3.5	5.4	8.1	2.7	2.7	2.9	-2.6	-1.9	2.2	2.2	2.6	1.4	2.2	1.6	2.5
Medication: Lisinopril	0.7	0.9	2.0	0.8	0.7	0.4	-0.9	-0.2	0.9	1.2	1.2	1.4	1.1	0.3	1.4
Medication: Atorvastatin	3.4	4.2	6.7	2.5	2.4	2.2	-2.2	-1.8	1.5	2.1	2.6	0.5	2.2	1.4	2.1
Illnesses of father: High blood pressure	0.1	0.2	0.5	-0.4	-0.1	-0.4	0.0	-0.3	0.1	-0.6	-0.6	-0.2	-0.7	0.2	-0.5
Alcohol drinker status: Never	0.5	0.6	1.2	-0.6	-1.1	-0.5	0.7	0.5	-0.1	-1.0	-1.0	0.4	-0.9	-1.1	-0.8
Ever smoked	0.8	1.5	3.5	1.0	1.0	0.6	-1.3	-1.9	1.8	0.6	1.5	1.1	0.9	-1.0	1.0
Basal metabolic rate	3.2	17.5	25.0	5.0	4.5	3.8	-4.9	-3.5	3.7	4.4	4.9	2.5	4.7	3.2	4.4
Leg fat percentage (left)	9.1	33.0	51.0	6.5	6.0	5.8	-6.2	-3.6	4.0	6.7	7.1	2.7	7.0	4.5	6.5
Arm fat-free mass (left)	3.3	17.0	24.2	4.8	4.3	3.7	-4.7	-3.0	3.5	4.5	4.9	2.6	4.8	3.1	4.5
Number of operations (self-reported)	1.9	2.8	5.9	1.5	1.1	1.9	-1.3	0.0	1.7	1.8	1.9	2.4	1.7	0.1	2.3
Average weekly beer plus cider intake	1.0	1.5	2.9	-1.2	-1.7	-0.7	1.3	1.1	-1.5	-1.0	-1.3	-1.2	-1.2	-0.6	-1.1
Irritability	5.0	8.4	11.4	-3.3	-3.1	-3.1	3.0	1.4	-2.7	-3.2	-3.3	-2.6	-3.2	-2.0	-3.4
Risk taking	0.0	0.1	0.3	-0.1	-0.2	-0.1	0.1	-0.2	0.2	-0.3	-0.0	0.2	-0.3	-0.5	-0.1
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.5	-0.4	0.1	0.1	0.4	-0.1	-0.4	-0.4	-0.2	-0.7	-0.5	-0.3	-0.4
Fractured/broken bones in last 5 years	1.2	1.6	4.0	-1.4	-1.7	-1.7	1.3	0.8	-0.4	-1.2	-0.9	0.1	-1.1	-2.0	-1.0
Age started oral contraceptive pill	0.5	0.6	0.8	0.5	0.7	0.9	-0.8	-0.4	0.8	0.8	0.9	0.8	0.9	0.7	0.9
Diastolic blood pressure, automated reading	3.0	9.3	12.6	3.5	3.6	2.9	-3.3	-2.2	2.6	3.2	3.5	2.0	3.5	2.2	3.5
Ever depressed for a whole week	1.2	1.5	3.6	1.5	1.9	1.2	-1.4	-1.6	1.1	0.8	1.0	0.3	1.0	1.1	0.9
Unable to work because of sickness or disability	4.3	5.5	8.8	3.0	2.5	2.0	-2.7	-1.7	2.2	2.4	2.3	1.6	2.4	2.6	2.5
Commuting to job workplace: Cycle	0.2	0.2	0.9	-0.3	-0.3	-0.3	0.3	0.3	0.4	-0.4	-0.4	0.8	-0.3	-0.9	-0.2
Myopia	0.2	0.2	1.1	-0.3	-0.1	-0.3	0.2	-0.4	0.2	-0.7	-0.3	0.0	-0.6	-1.1	-0.6
Vascular/heart problems diagnosed by doctor	0.9	2.5	4.1	-1.9	-1.9	-1.5	1.7	2.0	-2.0	-1.1	-1.7	-1.2	-1.5	-0.5	-1.3
Cholesterol lowering medication	1.1	1.6	2.8	1.7	1.4	1.4	-1.5	-1.5	1.2	1.0	1.0	0.4	1.1	1.4	1.0
Medication: Omeprazole (e.g. Zanprol)	1.3	1.6	2.6	1.3	1.4	1.4	-1.1	-0.1	0.9	1.5	1.4	1.2	1.5	0.9	1.6
Pain experienced in last month	0.5	0.8	2.0	-0.9	-1.0	-0.9	0.8	0.9	0.2	-0.9	-0.8	1.1	-0.7	-1.4	-0.6
Supplements: Calcium	0.5	0.6	1.7	-0.3	-0.7	0.1	0.1	-0.5	0.3	-1.2	-1.2	-0.1	-1.3	0.1	-1.1
Basal cell carcinoma (self-reported)	0.5	0.6	1.6	-1.2	-1.3	-0.9	0.9	1.1	-0.7	-0.2	-0.7	-0.1	-0.4	-0.5	-0.3
Heart attack/myocardial infarction (self-reported)	0.9	1.1	1.8	1.3	1.2	1.2	-1.2	-0.8	1.4	0.7	0.9	1.2	0.8	1.0	0.9
Deep venous thrombosis (DVT) (self-reported)	2.6	3.4	4.5	2.0	1.7	2.0	-2.1	-1.1	2.0	1.8	1.8	2.0	1.9	1.6	1.9
Heart disease (siblings)	1.6	2.0	4.5	1.4	0.9	1.1	-1.2	0.3	0.4	2.1	1.6	0.8	1.8	1.7	2.0
Alcohol drinker status: Previous	0.5	0.6	1.3	1.2	0.5	-0.3	-0.7	0.1	0.7	0.8	0.7	1.1	0.8	0.3	1.0
Pack years of smoking	2.0	2.9	5.4	1.9	1.8	1.2	-1.5	-0.4	1.0	2.2	1.8	1.2	2.3	1.8	2.1
Impedance of whole body	3.5	17.6	26.8	-4.7	-4.2	-4.3	4.4	2.2	-3.4	-4.9	-5.2	-3.3	-5.0	-2.5	-5.0
Leg fat mass (left)	11.1	43.3	66.7	7.5	6.8	6.4	-7.1	-4.2	4.7	7.7	8.2	3.3	8.0	5.1	7.5
Arm predicted mass (left)	3.6	18.3	26.0	5.0	4.5	4.0	-4.9	-3.4	3.7	4.6	5.1	2.5	4.9	3.3	4.6