[Hub]/) : Traits : Leg fat-free mass (left) :

chr17:27,200,734-30,380,381

Best TWAS P=1.63e-25 · Best GWAS P=3.52e-29 conditioned to NaN

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex NF1 0.06 0.01 blup 410 0.04 1.1e-05 6.89 6.2 4.8e-10 -0.20 0.95 0.00 FALSE
2 GTEx Adipose Visceral Omentum TEFM 0.12 0.02 lasso 14 0.05 1.0e-03 2.03 -6.2 7.8e-10 0.21 0.08 0.09 FALSE
3 GTEx Artery Aorta ABHD15 0.20 0.03 enet 36 0.06 2.9e-04 -5.03 -6.6 4.2e-11 0.08 0.01 0.74 TRUE
4 GTEx Artery Aorta TEFM 0.13 0.02 enet 34 0.03 5.8e-03 2.06 -6.7 2.4e-11 0.57 0.15 0.78 FALSE
5 GTEx Artery Aorta CRLF3 0.12 0.03 enet 33 0.06 3.8e-04 2.02 -7.5 4.6e-14 0.53 0.25 0.70 TRUE
6 GTEx Artery Tibial RP11-848P1.7 0.54 0.00 lasso 10 0.02 7.3e-03 -6.88 -10.4 1.6e-25 0.47 0.02 0.06 TRUE
7 GTEx Brain Cerebellar Hemisphere CRLF3 0.38 0.35 enet 26 0.35 6.0e-10 3.10 -6.2 4.5e-10 0.32 0.97 0.01 FALSE
8 GTEx Brain Cerebellum CRLF3 0.52 0.12 lasso 27 0.20 1.3e-06 -9.65 -9.1 1.0e-19 0.56 0.09 0.74 FALSE
9 GTEx Breast Mammary Tissue CRLF3 0.10 0.10 lasso 3 0.05 9.6e-04 3.78 -5.8 7.7e-09 0.31 0.09 0.62 FALSE
10 GTEx Cells EBV-transformed lymphocytes EVI2A 0.13 0.03 lasso 4 0.01 1.5e-01 6.89 -7.2 7.1e-13 0.17 0.16 0.04 FALSE
11 GTEx Cells Transformed fibroblasts OMG 0.06 0.02 lasso 2 0.01 2.5e-02 6.85 7.0 2.4e-12 -0.22 0.14 0.07 FALSE
12 GTEx Colon Transverse CRLF3 0.16 0.07 lasso 6 0.05 1.5e-03 2.02 -5.5 2.8e-08 0.42 0.15 0.64 FALSE
13 GTEx Esophagus Muscularis BLMH 0.15 0.02 lasso 8 0.01 1.0e-01 -3.61 5.6 2.6e-08 -0.13 0.04 0.46 TRUE
14 GTEx Esophagus Muscularis CRLF3 0.17 0.12 lasso 6 0.18 5.1e-11 3.14 -7.4 1.6e-13 0.46 0.94 0.05 FALSE
15 GTEx Muscle Skeletal TP53I13 0.08 0.02 lasso 4 0.02 2.2e-03 -5.03 6.2 7.9e-10 -0.08 0.00 0.87 TRUE
16 GTEx Nerve Tibial CRLF3 0.38 0.16 lasso 14 0.19 3.0e-13 3.25 -6.4 1.8e-10 0.38 1.00 0.00 FALSE
17 GTEx Ovary CRLF3 0.21 0.14 lasso 4 0.11 1.0e-03 3.14 -6.4 1.5e-10 0.40 0.06 0.58 FALSE
18 GTEx Pituitary SUZ12P 0.29 0.23 lasso 9 0.32 6.0e-09 3.10 -6.3 2.9e-10 0.40 0.86 0.07 TRUE
19 GTEx Spleen EVI2A 0.22 0.12 lasso 4 0.07 8.3e-03 6.74 -6.7 2.6e-11 0.17 0.11 0.05 FALSE
20 GTEx Spleen OMG 0.41 0.10 enet 26 0.08 4.5e-03 6.85 6.1 9.6e-10 -0.23 0.64 0.03 FALSE
21 GTEx Testis CRLF3 0.26 0.19 enet 23 0.17 3.8e-08 3.28 -5.8 7.9e-09 0.38 0.99 0.00 FALSE
22 GTEx Thyroid CRLF3 0.10 0.04 enet 35 0.08 1.1e-06 3.25 -6.2 7.1e-10 0.38 0.91 0.05 FALSE
23 GTEx Whole Blood EVI2A 0.07 0.04 lasso 4 0.04 2.6e-04 6.71 -7.0 3.1e-12 0.14 0.89 0.00 FALSE
24 METSIM Adipose CTD-2349P21.5 0.02 0.00 bslmm 252 0.01 3.0e-03 -8.21 -7.0 2.8e-12 0.33 0.04 0.31 FALSE
25 METSIM Adipose NF1 0.04 0.00 blup 396 0.01 5.5e-03 7.01 7.2 8.6e-13 -0.30 0.80 0.02 FALSE
26 METSIM Adipose TEFM 0.08 0.06 blup 246 0.06 8.8e-10 -11.21 -8.2 2.4e-16 0.57 0.00 1.00 TRUE
27 YFS Blood EVI2A 0.03 0.05 lasso 4 0.04 1.0e-13 6.74 -6.8 1.4e-11 0.10 1.00 0.00 FALSE
28 YFS Blood EVI2B 0.01 0.00 blup 339 0.00 6.4e-02 -0.36 6.5 6.1e-11 -0.26 0.07 0.02 FALSE
29 The Cancer Genome Atlas Bladder Urothelial Carcinoma EVI2A 0.03 0.03 blup 37 0.03 2.3e-03 6.71 -6.6 3.6e-11 0.10 0.04 0.54 FALSE
30 The Cancer Genome Atlas Bladder Urothelial Carcinoma OMG 0.02 0.02 blup 31 0.02 3.2e-03 6.69 -7.2 7.7e-13 0.15 0.03 0.78 FALSE
31 The Cancer Genome Atlas Breast Invasive Carcinoma EVI2A 0.03 0.03 blup 38 0.03 6.9e-07 6.64 -7.1 1.7e-12 0.12 0.09 0.91 FALSE
32 The Cancer Genome Atlas Breast Invasive Carcinoma GOSR1 0.02 0.01 enet 4 0.01 1.7e-02 -6.90 7.0 2.2e-12 -0.27 0.01 0.83 FALSE
33 The Cancer Genome Atlas Breast Invasive Carcinoma OMG 0.03 0.04 lasso 1 0.04 1.1e-08 6.97 -7.0 3.2e-12 0.23 0.01 0.99 FALSE
34 The Cancer Genome Atlas Colon Adenocarcinoma LRRC37B2 0.09 0.00 enet 11 0.03 7.3e-03 4.58 -6.7 2.7e-11 0.47 0.01 0.26 TRUE
35 The Cancer Genome Atlas Esophageal Carcinoma OMG 0.09 0.09 blup 31 0.11 2.0e-04 7.02 -7.3 3.9e-13 0.18 0.02 0.92 FALSE
36 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma OMG 0.02 0.02 blup 31 0.03 6.9e-04 7.00 -7.2 5.8e-13 0.17 0.02 0.89 FALSE
37 The Cancer Genome Atlas Brain Lower Grade Glioma EVI2A 0.03 0.03 blup 38 0.04 3.0e-05 6.66 -7.2 8.2e-13 0.16 0.04 0.96 FALSE
38 The Cancer Genome Atlas Liver Hepatocellular Carcinoma NF1 0.04 0.03 blup 111 0.03 1.3e-02 7.11 7.1 1.3e-12 -0.19 0.05 0.66 FALSE
39 The Cancer Genome Atlas Lung Adenocarcinoma EVI2A 0.04 0.06 blup 38 0.06 3.0e-07 6.58 -7.0 1.8e-12 0.15 0.08 0.92 FALSE
40 The Cancer Genome Atlas Lung Adenocarcinoma OMG 0.05 0.03 lasso 5 0.04 3.6e-05 6.66 -6.3 2.7e-10 0.10 0.06 0.86 FALSE
41 The Cancer Genome Atlas Lung Squamous Cell Carcinoma EVI2A 0.03 0.03 lasso 1 0.02 2.4e-03 6.52 -6.5 7.1e-11 0.10 0.04 0.38 FALSE
42 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma GOSR1 0.15 0.00 blup 56 0.04 1.1e-03 -4.04 6.9 5.1e-12 -0.35 0.04 0.19 FALSE
43 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma OMG 0.05 0.03 blup 32 0.03 5.6e-03 6.85 -6.8 1.0e-11 0.25 0.01 0.77 FALSE
44 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma CRLF3 0.28 0.13 blup 40 0.11 3.1e-05 2.97 -5.4 6.2e-08 0.28 0.33 0.06 TRUE
45 The Cancer Genome Atlas Prostate Adenocarcinoma EVI2A 0.08 0.12 lasso 3 0.12 1.3e-12 7.01 -7.0 2.4e-12 0.12 0.08 0.92 FALSE
46 The Cancer Genome Atlas Stomach Adenocarcinoma SUZ12P 0.05 0.05 blup 29 0.04 5.1e-04 3.78 -5.9 2.8e-09 0.32 0.16 0.16 TRUE
47 The Cancer Genome Atlas Thyroid Carcinoma OMG 0.02 0.01 blup 32 0.02 4.8e-03 6.85 -7.2 7.0e-13 0.18 0.02 0.87 FALSE